CN102697841B - Anti-aging compound preparation of Chinese herbs and production method of anti-aging compound preparation - Google Patents
Anti-aging compound preparation of Chinese herbs and production method of anti-aging compound preparation Download PDFInfo
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Abstract
The invention provides a production method of an anti-aging compound preparation of Chinese herbs. The compound preparation consists of 10 to 80 parts of Astragalus mongholicus, 10 to 80 parts of acanthopanax roots and 20 to 90 parts of wintercreeper, and the compound preparation also can comprise 1 to 50 parts of lucid ganoderma, 1 to 50 parts of gynostemma pentaphylla and 1 to 50 parts of pseudo-ginseng. Compared with the traditional alcohol precipitation method production process, the production method has the advantages that the filtered liquid which is obtained by adopting a high-speed centrifugal filtering process technology under an appropriate centrifugal condition is clear, the loss of active ingredients is less, the drug effect is improved, the dosage is reduced, the quality of the preparation product is improved, the production process is environment-friendly and economical, the cost is saved, and the application of organic solvent is avoided.
Description
Technical field
The invention provides a kind of production method of anti-aging compound recipe Chinese medicine preparation, specifically, provide a kind of improved production method of anti-aging compound recipe herb mixture.Belong to field of traditional Chinese medicine pharmacy.
Background technology
The delay aging drug compound mixture of applying clinically, prescription consists of: 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis, and can comprise 1～50 part of Ganoderma, 1～50 part of 1～50 part of Herb Gynostemmae Pentaphylli and Radix Notoginseng.It has the effect that kidney and spleen invigorating, QI invigorating and blood producing, strengthening the body resistance, eliminating phlegm to promote tissue regeneration, skin care increase intelligence, life lengthening, can be for defying age, regain one's strength and the prevention of cardiovascular disease etc.Animal pharmacodynamic study shows, it is active that this Chinese medicine compound has the SOD of raising, reduces activity of monoamine oxidase, and raising animal is heat-resisting, tolerance to cold, extend average life and the absolute life-span of animal, improve the mobility of animal, improve immunity, reduce lipid content in blood, reduce blood viscosity, hypertension is declined, drug induced animal intelligence is declined and improve, flow coronarius is increased.
CN1103803A discloses above-mentioned anti-aging compound recipe Chinese medicine preparation and production method thereof, adopts water extraction ethanol intermediate processing to make mixture.Although alcohol precipitation process is common technology in extract oral liquid preparation, but this technique exists many drawbacks, removing impurity component simultaneously, mass efficient composition is also lost, loss of effective components is serious, and ethanol consumption is large, the response rate is low, the production cycle is long, through precipitate with ethanol, processes, affect its active constituent content, greatly lower the inherent quality of finished product.
Summary of the invention
The object of the invention is to provide a kind of improved production method of simple, effective delay aging drug compound preparation.Technical solution of the present invention is as follows:
One of technical solution of the present invention is to provide a kind of production method of anti-aging compound recipe Chinese medicine preparation, it is characterized in that getting 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis, after mixing with any order, decoct with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time, collecting decoction, filter, filtrate is concentrated into the clear paste that proportion is 1.00～1.3 (heat is surveyed), described clear paste obtains clear liquor after treatment, clear liquor adds the steviosin of 0.003～0.01 part, add again 40～80 parts of water adjustment, filter, fill and get final product, it is characterized in that described processing is that described clear paste lets cool, staticly settle, get supernatant, through 16000 revs/min of high speed centrifugations of centrifugal rotational speed, filter, gained filtrate is clear liquor.
Two of technical solution of the present invention is to provide a kind of production method of anti-aging compound recipe Chinese medicine preparation, it is characterized in that getting 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis, 1～50 part of Ganoderma, 1～50 part of Herb Gynostemmae Pentaphylli, 1～50 part of Radix Notoginseng, after mixing with any order, decoct with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time, collecting decoction, filter, filtrate is concentrated into the clear paste that proportion is 1.00～1.3 (heat is surveyed), described clear paste obtains clear liquor after treatment, clear liquor adds the steviosin of 0.003～0.01 part, add again 40～80 parts of water adjustment, filter, fill and get final product, it is characterized in that described processing is that described clear paste lets cool, staticly settle, get supernatant, through 16000 revs/min of high speed centrifugations of centrifugal rotational speed, filter, gained filtrate is clear liquor.
The present invention is by improving research to the production technology of this anti-aging compound recipe herb mixture, find unexpectedly, this Chinese medicine compound water extract, under suitable centrifugal condition, carry out centrifugal filtration Technology, resulting filtrate clarification, loss of effective components is few, improves drug effect, reduce dose, increased the stability of preparation and the quality of product.Production method of the present invention is compared and is had significant advantage with existing alcohol deposition method production technology, as shortened technological process, saved a large amount of ethanol, produce the safety that more becomes, and can reduce effective ingredient loses, make medicinal liquid clarity good, the precipitation that is long placed in appearance is few, and the polysaccharide composition with extensive physiologically active is retained substantially.Improve the active constituent content of preparation, realize serialization and produce, simplify technique, shorten the production cycle, reduce production costs, improve the stability of extract oral liquid formulation.
By embodiment, get and decoct with water the medicinal liquid having concentrated, be divided into two, adopt respectively two kinds of method preparations of prior art 94109342.5 (alcohol precipitation process) and the inventive method (centrifugal filtration technique), and by high effective liquid chromatography for measuring effective ingredient isofraxidin content, the results are shown in following table.Process effective ingredient isofraxidin content of the present invention has improved 39.2%, greatly improves the content of active component, and technique is simple, environmental protection, Financial cost reduce greatly, avoids having used organic solvent, eliminates the problems such as organic solvent residual.
| Preparation method | 1mL is containing isofraxidin (C 11H 10O 5) |
| (94109342.5 precipitate with ethanol) | 20.9μg/mL |
| The present patent application (centrifugal) | 29.1μg/mL |
Assay is pressed < < high performance liquid chromatography rule of operation > > and is measured:
Chromatographic condition and system suitability octadecylsilane chemically bonded silica are filler; 0.1% phosphoric acid solution-acetonitrile is mobile phase; Detection wavelength is 344nm.Number of theoretical plate calculates and should be not less than 2000 by isofraxidin peak.
It is appropriate that isofraxidin reference substance is got in the preparation of reference substance solution, accurately weighed, adds methanol and make every 1ml containing 20 μ g solution, obtains.
The preparation precision of need testing solution measures this product 20ml, and jolting is extracted 5 times, each 15ml, and merge extractive liquid,, evaporate to dryness, residue is with dissolve with methanol and be transferred in 5ml measuring bottle, adds methanol to scale, shakes up, and filters, and gets filtrate, obtains.
Algoscopy is accurate reference substance solution and each 10 μ l of need testing solution of drawing respectively, and injection liquid chromatography, measures, and obtains.
Stability comparative test result is as follows:
Get three batches of preparation lot numbers that make by embodiment 2 and be 111004,111005,111006 and by first to file 94109342.5, the preparation lot number that the identical prescription raw material of take is produced by alcohol precipitating method has carried out accelerated stability (40 ℃ ± 2 ℃, RH75% ± 5%) and long-time stability (25 ℃ ± 2 ℃, RH60% ± 10%) contrast test as 111001, and experimental data is as following table 1-2:
Table 1: accelerated stability test result
Table 2 long-term stable experiment result
Result of the test shows, the inventive method makes preparation and carried out accelerated test, long term test.Result of the test shows, the preparation of producing by embodiment and the preparation of pressing precipitate with ethanol production, and product quality is all stable, still, and the preparation that explained hereafter of the present invention makes, active constituent content significantly improves, and technique environmental protection more, economy, avoid with an organic solvent.
On the other hand, in mixture of the present invention, also use stevioside to replace sucrose as flavoring agent.Steviosin (also claiming stevioside) has the feature of high sugariness, low calorie, and its sugariness is 200-300 times of sucrose, and calorific value is only 1/300 of sucrose.Through high amount of drug, experiment showed, that stevioside has no side effect, without carcinogen, edible safety, also can prophylaxis of hypertension, the disease such as diabetes, obesity, heart disease, dental caries, and applies sucrose escapable cost 60%.Stevioside also has health, it is a kind of good health care sweetening agent, tool foreign foods expert and medical expert's clinical experiment confirm, this product has certain curative effect to sugar diabetes, hypertension, and obesity, cardiovascular disease, gastritis, oral disease, hyperchlorhydria etc. are also had to certain auxiliary therapeutic action.Therefore, anti-aging compound recipe Chinese medicine preparation of the present invention, as old people's medication, is used steviosin to replace sucrose as sweeting agent, is more suitable for old people's medication, improves the medication property followed, and preparation is more scientific and reasonable.
The specific embodiment
Embodiment 1:
Get Radix Astragali 6g, Radix Et Caulis Acanthopanacis Senticosi 6g, Caulis Seu Folium Euonymi Fortunei 8g, above 3 taste Chinese medicines decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is concentrated into the clear paste of proportion 1.00～1.20 (heat is surveyed), and described clear paste lets cool, staticly settles, and gets supernatant, through 16000 revs/min of high speed centrifugations of centrifugal rotational speed, filter, gained filtrate is clear liquor.Clear liquor adds about 2mg steviosin, adds water and is adjusted to 15ml, filters fill and get final product.Usage and consumption, oral, each potion, once a day or the every 2～3 days once.
Embodiment 2:
Get Radix Astragali 6g, Radix Et Caulis Acanthopanacis Senticosi 6g, Ganoderma 1g, Herb Gynostemmae Pentaphylli 1g, Radix Notoginseng 0.5g, Caulis Seu Folium Euonymi Fortunei 8g, above 6 taste Chinese medicines decoct with water secondary, and 2 hours for the first time, 1 hour for the second time, collecting decoction, filters, and filtrate is concentrated into the clear paste of proportion 1.00～1.20 (heat is surveyed), described clear paste lets cool, staticly settles, get supernatant, through 16000 revs/min of high speed centrifugations of centrifugal rotational speed, filter, gained filtrate is clear liquor.Clear liquor adds about 2mg steviosin, adds water and is adjusted to 15ml, filters fill and get final product.Usage and consumption, oral, each potion, once a day or the every 2～3 days once.
Claims (2)
1. the production method of an anti-aging compound recipe Chinese medicine preparation, get 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis, after mixing with any order, decoct with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time, collecting decoction, filter, filtrate is concentrated into proportion for the clear paste of heat survey 1.00～1.3, described clear paste obtains clear liquor after treatment, clear liquor adds the steviosin of 0.003～0.01 part, add again 40～80 parts of water adjustment, filter, fill and get final product, it is characterized in that described processing is that described clear paste lets cool, staticly settle, get supernatant, through 16000 revs/min of high speed centrifugations of centrifugal rotational speed, filter, gained filtrate is clear liquor.
2. the production method of an anti-aging compound recipe Chinese medicine preparation, it is characterized in that getting 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis, 1～50 part of Ganoderma, 1～50 part of Herb Gynostemmae Pentaphylli, 1～50 part of Radix Notoginseng, after mixing with any order, decoct with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time, collecting decoction, filter, filtrate is concentrated into proportion for the clear paste of heat survey 1.00～1.3, described clear paste obtains clear liquor after treatment, clear liquor adds the steviosin of 0.003～0.01 part, add again 40～80 parts of water adjustment, filter, fill and get final product, it is characterized in that described processing is that described clear paste lets cool, staticly settle, get supernatant, through 16000 revs/min of high speed centrifugations of centrifugal rotational speed, filter, gained filtrate is clear liquor.
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| CN103798473A (en) * | 2014-01-16 | 2014-05-21 | 戴明传 | Longevity healthcare tea |
| CN109091636B (en) * | 2018-10-30 | 2021-05-28 | 右江民族医学院 | Zhuang medicine formula for treating coronary heart disease and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1103803A (en) * | 1994-08-08 | 1995-06-21 | 浙江永宁制药厂 | Proprietary traditional Chinese medicine for anti-senility and the prepn. method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1103803A (en) * | 1994-08-08 | 1995-06-21 | 浙江永宁制药厂 | Proprietary traditional Chinese medicine for anti-senility and the prepn. method |
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