CN102697841A - Anti-aging compound preparation of Chinese herbs and production method of anti-aging compound preparation - Google Patents
Anti-aging compound preparation of Chinese herbs and production method of anti-aging compound preparation Download PDFInfo
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- CN102697841A CN102697841A CN2012102022612A CN201210202261A CN102697841A CN 102697841 A CN102697841 A CN 102697841A CN 2012102022612 A CN2012102022612 A CN 2012102022612A CN 201210202261 A CN201210202261 A CN 201210202261A CN 102697841 A CN102697841 A CN 102697841A
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Abstract
The invention provides a production method of an anti-aging compound preparation of Chinese herbs. The compound preparation consists of 10 to 80 parts of Astragalus mongholicus, 10 to 80 parts of acanthopanax roots and 20 to 90 parts of wintercreeper, and the compound preparation also can comprise 1 to 50 parts of lucid ganoderma, 1 to 50 parts of gynostemma pentaphylla and 1 to 50 parts of pseudo-ginseng. Compared with the traditional alcohol precipitation method production process, the production method has the advantages that the filtered liquid which is obtained by adopting a high-speed centrifugal filtering process technology under an appropriate centrifugal condition is clear, the loss of active ingredients is less, the drug effect is improved, the dosage is reduced, the quality of the preparation product is improved, the production process is environment-friendly and economical, the cost is saved, and the application of organic solvent is avoided.
Description
Technical field
The present invention provides a kind of production method of anti-aging compound recipe Chinese medicine preparation, specifically, a kind of improved production method of anti-aging compound recipe herb mixture is provided.Belong to field of traditional Chinese medicine pharmacy.
Background technology
The delay aging drug compound mixture of using clinically, prescription consists of: 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis, and can comprise 1～50 part of Ganoderma, 1～50 part of 1～50 part of Herb Gynostemmae Pentaphylli and Radix Notoginseng.It has kidney and spleen invigorating, QI invigorating and blood producing, strengthening the body resistance, eliminating phlegm to promote tissue regeneration, skin care and increases intelligence, effect of prolonging life, can be used for defying age, regains one's strength with the prevention of cardiovascular disease etc.The animal pharmacodynamic study shows that this Chinese medicine compound has SOD activity improving, reducing activity of monoamine oxidase; Improve heat-resisting, the tolerance to cold of animal, prolong the average life and absolute life-span of animal, improve the mobility of animal; Improve immunity, reduce lipid content in the blood, blood viscosity lowering; Hypertension is descended, drug induced animal intelligence is descended improve, flow coronarius is increased.
CN1103803A discloses above-mentioned anti-aging compound recipe Chinese medicine preparation and production method thereof, adopts water extraction ethanol precipitation method to make mixture.Though alcohol precipitation process is a common technology in the extract oral liquid preparation, this technology exists many drawbacks, is removing impurity component simultaneously; The mass efficient composition is also lost; Loss of effective components is serious, and amount of ethanol is big, the response rate is low, the production cycle is long, handles through precipitate with ethanol; Influence its active constituent content, lower the inherent quality of finished product greatly.
Summary of the invention
The object of the invention is to provide a kind of improved production method of simple, effective delay aging drug compound preparation.Technical scheme of the present invention is following:
One of technical scheme of the present invention provides a kind of production method of anti-aging compound recipe Chinese medicine preparation, it is characterized in that getting 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis; Behind any order mixing, decocte with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time; Collecting decoction filters, and filtrating is concentrated into the clear paste that proportion is 1.00～1.3 (heat is surveyed); Said clear paste obtains clear liquor after treatment, and clear liquor adds 0.003～0.01 part steviosin, adds 40～80 parts of water adjustment again; Filter, fill promptly gets, and it is characterized in that described processing to be that said clear paste is put cold, staticly settles; Get supernatant, filter through 16000 rev/mins of high speed centrifugations of centrifugal rotational speed, gained filtrating is clear liquor.
Two of technical scheme of the present invention provides a kind of production method of anti-aging compound recipe Chinese medicine preparation, it is characterized in that getting 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis; 1～50 part of Ganoderma, 1～50 part of Herb Gynostemmae Pentaphylli, 1～50 part of Radix Notoginseng is behind any order mixing; The decocte with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time, collecting decoction; Filter, filtrating is concentrated into the clear paste that proportion is 1.00～1.3 (heat is surveyed), and said clear paste obtains clear liquor after treatment, and clear liquor adds 0.003～0.01 part steviosin; Add the adjustment of 40～80 parts of water again, filter, fill promptly gets, and it is characterized in that described processing to be that said clear paste is put cold, staticly settles; Get supernatant, filter through 16000 rev/mins of high speed centrifugations of centrifugal rotational speed, gained filtrating is clear liquor.
The present invention finds this Chinese medicine compound water extract unexpectedly through the production technology of this anti-aging compound recipe herb mixture is improved research; Under suitable centrifugal condition, carry out the centrifugal filtration Technology; Resulting filtrating clarification, loss of effective components is few, improves drug effect; Reduce dose, increased the quality of stability of formulation and product.Production method of the present invention is compared with existing alcohol deposition method production technology and is had significant advantage; As shortened technological process, and practiced thrift a large amount of ethanol, produce the safety that more becomes; And can reduce effective ingredient loses; It is good to make medicinal liquid clarity, and the deposition of putting appearance for a long time is few, and the polysaccharide composition with extensive physiologically active is able to keep basically.Improve the active constituent content of preparation, realize serialization production, simplify technology, shorten the production cycle, reduce production costs, improve the Chinese medicine oral liquid stability of formulation.
Get decocte with water by embodiment and concentrate good medicinal liquid; Be divided into two; Adopt two kinds of method preparations of prior art 94109342.5 (alcohol precipitation process) and the inventive method (centrifugal filtration technology) respectively, and through high effective liquid chromatography for measuring effective ingredient isofraxidin content, the result is shown in following table.Process effective ingredient isofraxidin content of the present invention has improved 39.2%, improves the content of active component greatly, and technology is simple, environmental protection, Financial cost reduce greatly, has avoided the use of organic solvent, eliminates problems such as organic solvent residual.
| Method for preparing | 1mL contains isofraxidin (C 11H 10O 5) |
| (94109342.5 precipitate with ethanol) | 20.9μg/mL |
| Application of the present invention (centrifugal) | 29.1μg/mL |
Assay is measured by " HPLC rule of operation ":
Chromatographic condition and system suitability test use octadecylsilane chemically bonded silica to be filler; 0.1% phosphoric acid solution-acetonitrile is a mobile phase; The detection wavelength is 344nm.Number of theoretical plate calculates by the isofraxidin peak should be not less than 2000.
It is an amount of that the isofraxidin reference substance is got in the preparation of reference substance solution, accurate claims surely, adds methanol and process every 1ml and contain 20 μ g solution, promptly gets.
The preparation precision of need testing solution is measured these article 20ml, and jolting is extracted 5 times, each 15ml, and merge extractive liquid,, evaporate to dryness, residue is with dissolve with methanol and be transferred in the 5ml measuring bottle, adds methanol to scale, shakes up, and filters, and gets filtrating, promptly gets.
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, and promptly get.
The stability comparative test result is following:
Get three batches of preparation lot numbers that make by embodiment 2 and be 111004,111005,111006 and by in first to file 94109342.5; Is 111001 to have carried out accelerated stability (40 ℃ ± 2 ℃, RH75% ± 5%) and long-time stability (25 ℃ ± 2 ℃, RH60% ± 10%) contrast test, experimental data such as following table 1-2 with identical prescription raw material by the preparation lot number of alcohol precipitating method production:
Table 1: accelerated stability test result
Table 2 long-term stable experiment result
Result of the test shows that the inventive method makes preparation and carried out accelerated test, long term test.Result of the test shows, presses embodiment preparation of producing and the preparation of pressing precipitate with ethanol production, and product quality is all stable, still, the preparation that explained hereafter of the present invention makes, active constituent content significantly improves, and technology environmental protection more, economy avoid the use of organic solvent.
On the other hand, in the mixture of the present invention, also use the stevioside place of sucrose as flavoring agent.Steviosin (also claiming stevioside) has the characteristics of high sugariness, low heat energy, and its sugariness is 200-300 a times of sucrose, and calorific value is merely 1/300 of sucrose.Experiment showed, that through high amount of drug stevioside has no side effect, no carcinogen, edible safety, but diseases such as prophylaxis of hypertension, diabetes, obesity, heart disease, dental caries also, and use sucrose escapable cost 60%.Stevioside also has health; It is a kind of good health care sweetening agent; Tool foreign foods expert and medical expert's clinical experiment confirm; This product has certain curative effect to sugar diabetes, hypertension, and obesity, cardiovascular disease, gastritis, oral disease, hyperchlorhydria etc. are also had certain auxiliary treatment effect.Therefore, anti-aging compound recipe Chinese medicine preparation of the present invention as old people's medication, uses the steviosin place of sucrose as sweeting agent, is more suitable for old people's medication, improves the medication property followed, and preparation is more scientific and reasonable.
The specific embodiment
Embodiment 1:
Get Radix Astragali 6g, Radix Et Caulis Acanthopanacis Senticosi 6g, Caulis Seu Folium Euonymi Fortunei 8g, more than 3 flavor Chinese medicine decocte with water secondaries; 2 hours for the first time, 1 hour for the second time, collecting decoction; Filter, filtrating is concentrated into the clear paste of proportion 1.00～1.20 (heat is surveyed), and that said clear paste is put is cold, staticly settle; Get supernatant, filter through 16000 rev/mins of high speed centrifugations of centrifugal rotational speed, gained filtrating is clear liquor.Clear liquor adds about 2mg steviosin, adds water and is adjusted to 15ml, filters, and fill promptly gets.Usage and consumption, oral, each potion, once a day or the once at a distance from 2～3 days.
Embodiment 2:
Get Radix Astragali 6g, Radix Et Caulis Acanthopanacis Senticosi 6g, Ganoderma 1g, Herb Gynostemmae Pentaphylli 1g; Radix Notoginseng 0.5g, Caulis Seu Folium Euonymi Fortunei 8g, more than 6 flavor Chinese medicine decocte with water secondaries, 2 hours for the first time; 1 hour for the second time, collecting decoction filtered, and filtrating is concentrated into the clear paste of proportion 1.00～1.20 (heat is surveyed); That said clear paste is put is cold, staticly settle, and gets supernatant, filters through 16000 rev/mins of high speed centrifugations of centrifugal rotational speed, and gained filtrating is clear liquor.Clear liquor adds about 2mg steviosin, adds water and is adjusted to 15ml, filters, and fill promptly gets.Usage and consumption, oral, each potion, once a day or the once at a distance from 2～3 days.
Claims (2)
1. the production method of an anti-aging compound recipe Chinese medicine preparation is got 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis; Behind any order mixing, decocte with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time; Collecting decoction filters, and filtrating is concentrated into the clear paste that proportion is 1.00～1.3 (heat is surveyed), and said clear paste obtains clear liquor after treatment; Clear liquor adds 0.003～0.01 part steviosin, adds 40～80 parts of water adjustment again, filters, and fill promptly gets; It is characterized in that described processing to be that said clear paste is put cold, staticly settle, get supernatant, filter through 16000 rev/mins of high speed centrifugations of centrifugal rotational speed, gained filtrating is clear liquor.
2. the production method of an anti-aging compound recipe Chinese medicine preparation is characterized in that getting 10～80 parts of the Radixs Astragali, 10～80 parts of Radix Et Caulis Acanthopanacis Senticosis, 20～90 parts of Caulis Seu Folium Euonymi Fortuneis; 1～50 part of Ganoderma, 1～50 part of Herb Gynostemmae Pentaphylli, 1～50 part of Radix Notoginseng is behind any order mixing; The decocte with water secondary, 0.5～3 hour for the first time, 0.5～3 hour for the second time, collecting decoction; Filter, filtrating is concentrated into the clear paste that proportion is 1.00～1.3 (heat is surveyed), and said clear paste obtains clear liquor after treatment, and clear liquor adds 0.003～0.01 part steviosin; Add the adjustment of 40～80 parts of water again, filter, fill promptly gets, and it is characterized in that described processing to be that said clear paste is put cold, staticly settles; Get supernatant, filter through 16000 rev/mins of high speed centrifugations of centrifugal rotational speed, gained filtrating is clear liquor.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103798473A (en) * | 2014-01-16 | 2014-05-21 | 戴明传 | Longevity healthcare tea |
| CN109091636A (en) * | 2018-10-30 | 2018-12-28 | 右江民族医学院 | A kind of strong medicine composition and preparation method thereof for treating coronary heart disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103803A (en) * | 1994-08-08 | 1995-06-21 | 浙江永宁制药厂 | Proprietary traditional Chinese medicine for anti-senility and the prepn. method |
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2012
- 2012-06-19 CN CN201210202261.2A patent/CN102697841B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103803A (en) * | 1994-08-08 | 1995-06-21 | 浙江永宁制药厂 | Proprietary traditional Chinese medicine for anti-senility and the prepn. method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103798473A (en) * | 2014-01-16 | 2014-05-21 | 戴明传 | Longevity healthcare tea |
| CN109091636A (en) * | 2018-10-30 | 2018-12-28 | 右江民族医学院 | A kind of strong medicine composition and preparation method thereof for treating coronary heart disease |
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| Publication number | Publication date |
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| CN102697841B (en) | 2014-04-23 |
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