CN111558015A - A Chinese medicinal composition for treating alopecia - Google Patents

A Chinese medicinal composition for treating alopecia Download PDF

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CN111558015A
CN111558015A CN202010403415.9A CN202010403415A CN111558015A CN 111558015 A CN111558015 A CN 111558015A CN 202010403415 A CN202010403415 A CN 202010403415A CN 111558015 A CN111558015 A CN 111558015A
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weight
chinese medicine
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hair
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叶建州
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Yunnan Provincial Hospital of Traditional Chinese Medicine
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Yunnan Provincial Hospital of Traditional Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9064Amomum, e.g. round cardamom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

The invention discloses a traditional Chinese medicine composition for treating alopecia, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition comprises the following components in percentage by weight: 18-22 parts of lucid ganoderma, 4-6 parts of prepared fleece-flower root, 18-22 parts of wolfberry fruit, 18-22 parts of mulberry fruit, 6-10 parts of ginseng, 18-22 parts of astragalus root, 6-8 parts of epimedium herb, 8-12 parts of pseudo-ginseng, 8-12 parts of rhizoma polygonati, 6-8 parts of angelica and 3-5 parts of fructus amomi. The traditional Chinese medicine composition has the effects of nourishing liver and kidney, benefiting qi and nourishing blood; can be used for treating alopecia caused by deficiency of liver and kidney or deficiency of qi and blood; dizziness, amnesia, fatigue, insomnia, dreaminess, soreness of the waist and knees, etc.

Description

A Chinese medicinal composition for treating alopecia
Technical Field
The invention relates to a traditional Chinese medicine composition for treating alopecia, and belongs to the technical field of traditional Chinese medicine preparation.
Background
Alopecia is the phenomenon of hair loss, and is divided into physiological and pathological. Physiological alopecia refers to normal shedding of hair; pathologic hair loss refers to abnormal or excessive hair loss. With the increasing social pressure and the increasing pace of life, the continuous deterioration of the environment and the eating habits of poor diet, along with the increasing unhealthy and sub-healthy state of people, more and more alopecia patients are in China. According to the traditional Chinese medicine, the cause of alopecia is mainly in kidneys, if the deficiency of both liver and kidney qi and blood is caused, the blood circulation of the whole body is weak, nutrient substances cannot be conveyed to the top of the head at the highest position of the human body, hair follicles on the head cannot be nourished and gradually atrophy, alopecia can be caused, kidney essence is stored, the hair is mainly reproduced and blooms on the hair, the hair is the surplus of blood, the kidneys are considered as the congenital foundation, the hair is a product of the blood, the kidney essence is stored, liver blood is stored, and the essence and the blood are homologously transformed, and the deficiency of the kidney essence and the liver essence and the blood is not enough, meanwhile, the mode of treating alopecia by the traditional Chinese medicine is developed around the theories, and: kidney deficiency: kidneys store essence of five zang organs and six fu organs, deficiency of essence and blood due to kidney deficiency causes lack of nutrition supply to hair, and hair loss is caused. Lung damage: the lung governs fur, the lung fails to lead the fur, the lung is the most main oxygen and waste exchange organ of the human body, the lung has strong and weak functions and directly influences oxygen inhalation, waste discharge and nutrient supply in the body, the hair is the tail end organ of the body, and the lung fails to nourish the fur and causes alopecia. Toxin accumulation: worry, pollution, bad habits and the like can cause the human body to absorb, generate and accumulate a large amount of toxins, the toxins can damage all organs and all systems of the human body on the one hand, and influence all organs and hair of the human body to absorb nutrients on the other hand, so that various nourishing foods and medicines can not play a role to cause alopecia, and many methods for treating alopecia have poor effects because the toxins in the human body are not removed. The alopecia is generally treated by food therapy, such as eating more vegetables and fruits. At present, various anti-hair loss shampoos, hair growing liquids and hair growing liquids exist in the market, but the hair growing shampoos and hair growing liquids all treat symptoms, do not treat root causes, and have an unobvious effect, so that a traditional Chinese medicine preparation which can fundamentally solve the problem of hair loss and is convenient to take is urgently needed to be found.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine formula for treating alopecia, wherein the traditional Chinese medicine composition comprises 18-22 parts by weight of lucid ganoderma, 4-6 parts by weight of prepared fleece-flower root, 18-22 parts by weight of medlar, 18-22 parts by weight of mulberry, 6-10 parts by weight of ginseng, 18-22 parts by weight of astragalus root, 6-8 parts by weight of epimedium herb, 8-12 parts by weight of pseudo-ginseng, 8-12 parts by weight of rhizoma polygonati, 6-8 parts by weight of angelica and 3-5 parts by weight of fructus amomi.
Preferably, the traditional Chinese medicine formula for treating alopecia comprises the following components in percentage by weight: the traditional Chinese medicine composition comprises 20 parts by weight of lucid ganoderma, 5 parts by weight of prepared fleece-flower root, 20 parts by weight of medlar, 20 parts by weight of mulberry, 8 parts by weight of ginseng, 20 parts by weight of astragalus membranaceus, 7 parts by weight of epimedium, 10 parts by weight of pseudo-ginseng, 10 parts by weight of rhizoma polygonati, 7 parts by weight of angelica and 4 parts by weight of fructus amomi.
The traditional Chinese medicine formula for treating alopecia is taken in a mode that raw materials are crushed and prepared into traditional Chinese medicine pills according to a conventional method, 8g of the traditional Chinese medicine pills are taken every time, and the dosage is 2 times per day.
Square solution: the lucid ganoderma is a monarch drug, the medicines are used for regulating liver, tonifying spleen and kidney, supplementing qi, tonifying kidney, strengthening lung and spleen, promoting the production of blood, and nourishing yin, the ginseng is used for tonifying qi, relieving depletion, tonifying lung, tonifying spleen, promoting the production of body fluid, tranquilizing the mind, nourishing the mind, tonifying intelligence, the epimedium is used for tonifying kidney yang, strengthening bones and muscles, expelling wind-damp, the sealwort is used for tonifying qi, tonifying spleen, moistening lung, tonifying kidney is used as a ministerial drug, the yin and yang tonifying effect is achieved, the pseudo-ginseng is used for activating blood circulation to dissipate blood stasis, and the pain is used as an adjuvant drug. Dang Gui can tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Sha ren has the actions of moving qi and relieving epigastric distention, strengthening spleen and resolving dampness as a guiding drug.
The principle of medication is as follows: 1. it is forbidden for patients with hepatic insufficiency or abnormal biochemical index of liver.
2. It is forbidden for pregnant women.
3. Patients with a known individual history of liver injury for the product or formula are not suitable for use.
The invention has the beneficial effects that: the traditional Chinese medicine composition has the effects of nourishing liver and kidney, benefiting qi and nourishing blood; can be used for treating alopecia caused by deficiency of liver and kidney or deficiency of qi and blood; dizziness, amnesia, fatigue, insomnia, dreaminess, soreness of the waist and knees, etc. Clinical tests prove that the effective rate of 480 patients suffering from seborrheic alopecia is 91.2%, and the curative effect of 210 patients suffering from alopecia areata is 89.3%.
Detailed Description
The present invention will be described in further detail with reference to specific examples, but the scope of the present invention is not limited to the examples.
Example 1
A traditional Chinese medicine formula for treating alopecia, wherein the traditional Chinese medicine composition comprises: 200g of lucid ganoderma, 50g of prepared fleece-flower root, 200g of medlar, 200g of mulberry, 80g of ginseng, 200g of astragalus, 70g of epimedium, 100g of pseudo-ginseng, 100g of rhizoma polygonati, 70g of angelica and 40g of fructus amomi.
Example 2
A traditional Chinese medicine formula for treating alopecia, wherein the traditional Chinese medicine composition comprises: 180g of lucid ganoderma, 40g of prepared fleece-flower root, 180g of medlar, 180g of mulberry, 60g of ginseng, 220g of astragalus, 60g of epimedium, 80g of pseudo-ginseng, 80g of rhizoma polygonati, 60g of angelica and 30g of fructus amomi.
Example 3
A traditional Chinese medicine formula for treating alopecia, wherein the traditional Chinese medicine composition comprises: 220g of lucid ganoderma, 60g of prepared fleece-flower root, 220g of medlar, 220g of mulberry, 100g of ginseng, 180g of astragalus, 80g of epimedium, 120g of pseudo-ginseng, 120g of rhizoma polygonati, 80g of angelica and 50g of fructus amomi.
The traditional Chinese medicine formula for treating alopecia is taken in a mode that the raw materials in the embodiments 1-3 are randomly taken, smashed and prepared into traditional Chinese medicine pills according to a conventional method, wherein 10g of the traditional Chinese medicine pills are taken each time, and 2 times per day are taken.
Treatment of diseases
Patient complaints are: the hair was flaked to half a month of total loss.
Initial diagnosis: the patients complain that the hair is black and dense, the scalp itch is gradually aggravated before the half month due to poor sleep quality, the hair is flaked and falls off, and the hair falls off completely after the half month. Because of unwilling from western medicine treatment, we refer to the diagnosis and treatment by introduction, and the history of drinking wine exists; and (4) checking: generally, the hair is usually good and falls off basically, and only the left side and the back occiput of the hair have normal hair size of about 2X 2cm, accompanied by dry and bitter mouth, pruritus scalp, yellow urine, red tongue with yellow and greasy coating and wiry pulse.
Western medicine: common alopecia
And (3) diagnosis: traditional Chinese medicine: oil wind;
syndrome type: internal retention of damp-heat
Therapeutic method: 10g each time, 2 times per day.
Second visit (2015, 2 months and 18 days): after taking the medicine according to the previous method, scalp itch is relieved, the mouth is dry and bitter, the urine is yellow and slightly reduced, the tongue is red, the coating is yellow and greasy, and the pulse is wiry. And (5) keeping the prescription for continuous use.
Three diagnoses (3 months and 3 days in 2015): scalp itching disappeared, dry and bitter mouth was relieved, vellus hair growth was visible on the local scalp, red tongue with yellow coating, and wiry pulse.
After 3 months of treatment, all symptoms disappear, and the hair grows completely.
The alopecia totalis described in this example is one kind of alopecia areata, and mainly falls off all hairs. The etiology of this disease is unknown, and may be related to factors such as mental factors, sleep, endocrine, local lesions, etc. The traditional Chinese medicine is called as 'oily wind'. The theory of all disease sources says that: the kidney meridian of foot-Shaoyin is also the dominant kidney. … … if blood is abundant, it will nourish the beard and hair, so it will beautify the beard and hair; if the blood and qi are weakened, the meridians fail to nourish and moisten, so alopecia will occur. The medicine for nourishing blood, tranquillizing mind, growing hair and blackening hair is applied on the basis of treatment based on syndrome differentiation in clinical symptoms, and can be used for treating all symptoms together.
Case 2
Patient complaints are: the hair is greasy and has alopecia for more than 1 year.
Initial diagnosis: before the patient appeals for more than 1 year, after staying up and eating spicy, the scalp and the face are greasy and obvious, 50-70 hair loss is generated every day, more than 100 hair loss is generated after each hair washing, scalp itching is accompanied, attention is not paid, the hair loss is gradually spread to the center of the head from the forehead at two sides, scales are accompanied sometimes, and the hair loss is not obviously improved after hair washing is repeated for many times. To seek systemic treatment, the patient comes to the outpatient service of our hospital. The symptoms are as follows: the scalp and face are greasy, the hair on the top of the head is sparse, and part of hair follicles are atrophic. Pinsu has symptoms of soreness and weakness of waist and knees, itching scalp, normal stool, pale tongue with thin and white fur, and wiry and western pulse after delayed menstruation.
And (3) diagnosis: western medicine: androgenetic alopecia (seborrheic alopecia)
Traditional Chinese medicine: hair decay and alopecia
Syndrome type: syndrome of yin deficiency of liver and kidney
Therapeutic method: 10g each time, 2 times per day. The administration is continued for 2 weeks. Avoid greasiness and irritation to food. Avoid staying up all night.
Second diagnosis (5 months and 10 days in 2018): after the traditional method is used, the scalp and face are greasy, the pruritus is relieved, the hair loss amount is reduced by 30-40 roots per day, the tongue is pale red, the coating is thin and white, and the pulse is wiry and thin. The medicine is taken by the guardian for 2 weeks.
Three diagnoses (5 months and 25 days in 2018): the greasiness of the scalp and the face is obviously relieved, the scales are reduced, the scalp itch disappears, the menstruation is normal, the waist and the knees are sour, soft and better, the tongue is pale red, the coating is thin and white, and the pulse is string and thin.
After 3 months of treatment, all symptoms disappear, and 10-20 alopecia/day can show hair growth on both sides of forehead and top of head.
The alopecia totalis described in this example is one kind of alopecia areata, and mainly falls off all hairs. The etiology of this disease is unknown, and may be related to factors such as mental factors, sleep, endocrine, local lesions, etc. The traditional Chinese medicine is called as 'oily wind'. The theory of all disease sources says that: the kidney meridian of foot-Shaoyin is also the dominant kidney. … … if blood is abundant, it will nourish the beard and hair, so it will beautify the beard and hair; if the blood and qi are weakened, the meridians fail to nourish and moisten, so alopecia will occur. The medicine for nourishing blood, tranquillizing mind, growing hair and blackening hair is applied on the basis of treatment based on syndrome differentiation in clinical symptoms, and can be used for treating all symptoms together.
By adopting the formula disclosed by the invention, the effective rate of 480 patients with seborrheic alopecia is 91.2% and the curative effect of 210 patients with alopecia areata is 89.3% through clinical observation in 2016 + 2017 of the family.

Claims (2)

1. A traditional Chinese medicine composition for treating alopecia is characterized in that: the traditional Chinese medicine composition comprises 18-22 parts by weight of lucid ganoderma, 4-6 parts by weight of prepared fleece-flower root, 18-22 parts by weight of wolfberry fruit, 18-22 parts by weight of mulberry, 6-10 parts by weight of ginseng, 18-22 parts by weight of astragalus membranaceus, 6-8 parts by weight of epimedium herb, 8-12 parts by weight of pseudo-ginseng, 8-12 parts by weight of rhizoma polygonati, 6-8 parts by weight of angelica and 3-5 parts by weight of fructus amomi.
2. The traditional Chinese medicine composition for treating alopecia according to claim 1, which is characterized in that: the traditional Chinese medicine composition comprises 20 parts by weight of lucid ganoderma, 5 parts by weight of prepared fleece-flower root, 20 parts by weight of medlar, 20 parts by weight of mulberry, 8 parts by weight of ginseng, 20 parts by weight of astragalus membranaceus, 7 parts by weight of epimedium, 10 parts by weight of pseudo-ginseng, 10 parts by weight of rhizoma polygonati, 7 parts by weight of angelica and 4 parts by weight of fructus amomi.
CN202010403415.9A 2020-05-13 2020-05-13 A Chinese medicinal composition for treating alopecia Pending CN111558015A (en)

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1105571A (en) * 1994-01-20 1995-07-26 陈颖 Traditional Chinese medicine- "zaishengling" for curing alopecia
CN101020042A (en) * 2007-02-07 2007-08-22 王均明 Hair restoring medicine and its prepn
CN101732488A (en) * 2008-11-17 2010-06-16 李宝霞 Hair nourishing composition
CN101972222A (en) * 2010-11-03 2011-02-16 宁夏欣发宝养发有限公司 Hair-care liquid and preparation method thereof
CN102106985A (en) * 2011-02-23 2011-06-29 徐海彬 Medicament for treating alopecia
CN102133299A (en) * 2010-06-13 2011-07-27 吕奎荣 Traditional Chinese medicine composite for curing alopecia areata and alopecia
CN102836340A (en) * 2008-04-17 2012-12-26 成都地奥集团天府药业股份有限公司 Pharmaceutical composition for benefiting vital energy, enriching blood and nourishing liver and kidney as well as preparation method and application thereof
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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1105571A (en) * 1994-01-20 1995-07-26 陈颖 Traditional Chinese medicine- "zaishengling" for curing alopecia
CN101020042A (en) * 2007-02-07 2007-08-22 王均明 Hair restoring medicine and its prepn
CN102836340A (en) * 2008-04-17 2012-12-26 成都地奥集团天府药业股份有限公司 Pharmaceutical composition for benefiting vital energy, enriching blood and nourishing liver and kidney as well as preparation method and application thereof
CN101732488A (en) * 2008-11-17 2010-06-16 李宝霞 Hair nourishing composition
CN102133299A (en) * 2010-06-13 2011-07-27 吕奎荣 Traditional Chinese medicine composite for curing alopecia areata and alopecia
CN101972222A (en) * 2010-11-03 2011-02-16 宁夏欣发宝养发有限公司 Hair-care liquid and preparation method thereof
CN102106985A (en) * 2011-02-23 2011-06-29 徐海彬 Medicament for treating alopecia
CN104721383A (en) * 2015-02-27 2015-06-24 周舜宁 Hair-loss-preventing and hair caring traditional Chinese medicine composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
栾立云等: "活力苏口服液联合中药外洗治疗脂溢性脱发20例临床观察", 《河北中医》 *
王仑等: "活力苏口服液治疗斑秃疗效观察", 《中国中医药信息杂志》 *
郝近大: "《中华人民共和国药典辅助说明•2010年版一部•中成药》", 31 January 2012, 中国中医药出版社 *

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