CN111557876A - Composition, skin care product and preparation method thereof - Google Patents
Composition, skin care product and preparation method thereof Download PDFInfo
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- CN111557876A CN111557876A CN202010527933.1A CN202010527933A CN111557876A CN 111557876 A CN111557876 A CN 111557876A CN 202010527933 A CN202010527933 A CN 202010527933A CN 111557876 A CN111557876 A CN 111557876A
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- composition
- ascorbic acid
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- cream
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
The invention relates to the technical field of cosmetics, and particularly relates to a composition, a skin care product and a preparation method thereof. The preparation raw materials of the composition comprise 1-5 parts of a compound represented by the formula (1) and 2-5 parts of a stabilizer, and a buffer solution is used for supplementing the pH value to 6-7; the stabilizer comprises ascorbic acid and/or a salt thereof. The composition provided by the invention has an excellent whitening effect, no pungent smell, good skin moistening performance, mildness and no irritation; the composition has high stability, does not change color for 12 months, and ensures the long-time whitening effect of the composition.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a composition, a skin care product and a preparation method thereof.
Background
The bright, white and ruddy skin is always sought by oriental women, and is more popular fashion in China and women in Japan, southeast Asia and other countries in recent years, so that the market of skin care products for whitening and removing freckles is increasingly active, and the product sale is increased day by day, and the skin care products become one of the mainstream varieties of skin care cosmetics. The research on the aspects of whitening, whitening agents, whitening and freckle removing effect evaluation, whitening mechanism and the like is continuous and deep, and has attracted extensive attention of many scientific research institutions and manufacturers at home and abroad. With the continuous improvement of the living standard of people and the change of science and technology, the demand of people on skin care products is transformed from the past single care type to the modern functional type. Especially, with the increasing pace of life and work and the destruction of the environment and ozone layer caused by pollution in recent years, the metabolism of melanin-forming enzymes is disturbed, thereby leading to the increase of people suffering from various black spot symptoms. In view of this, whitening skin care products are becoming a relatively popular functional skin care product in recent years in the cosmetic field.
However, the stability and whitening efficacy of skin care products are still problems to be solved on the basis of ensuring green and safety.
Disclosure of Invention
Aiming at some problems in the prior art, the invention provides a composition in a first aspect, and the composition comprises 1-5 parts by weight of a compound represented by formula (1) and 2-5 parts by weight of a stabilizer, wherein a buffer solution is used for supplementing the pH value to 6-7; the stabilizer comprises ascorbic acid and/or a salt thereof; the formula (1) is as follows:
wherein, X in the formula (1) is selected from any one of potassium, sodium, calcium and magnesium; r is selected from any one of hydrogen, C1-C5 alkoxy, C1-C5 alkyl, hydroxyl and carboxyl.
As a preferable technical scheme of the invention, the ascorbic acid is selected from one or more of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid, 3-O-ethyl ascorbic acid and 2-O-ethyl ascorbic acid.
In a preferred embodiment of the present invention, R in formula (1) is a C1-C5 alkoxy group, preferably a methoxy group.
In a preferred embodiment of the present invention, the ascorbic acid is 2-O-ethyl ascorbic acid.
As a preferable technical scheme of the invention, the stabilizing agent further comprises a plant extract, and the weight ratio of the plant extract to the ascorbic acid is (0.5-2): 1.
as a preferred embodiment of the present invention, the plant extract is selected from one or more of broadleaf holly leaf extract, angelica keiskei leaf extract, rosa roxburghii tratt extract, mangosteen pericarp extract, scutellaria root extract, glycyrrhiza extract, angelica root extract, grape seed extract, green tea extract, and mulberry root extract.
As a preferable technical scheme of the invention, the buffer is selected from one or more of a lactic acid/sodium lactate buffer, a citric acid/sodium citrate buffer, a succinic acid/sodium succinate buffer and a citric acid/sodium hydroxide buffer.
In a second aspect, the present invention provides a method for preparing the composition, which comprises: mixing the components of the composition.
In a third aspect of the invention, a skin care product comprising the composition is provided.
As a preferable technical scheme, the skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Compared with the prior art, the invention has the following beneficial effects:
the composition provided by the invention has an excellent whitening effect, no pungent smell, good skin moistening performance, mildness and no irritation; the composition has high stability, does not change color for 12 months, and ensures the long-time whitening effect of the composition.
Detailed Description
The present invention is illustrated by the following specific embodiments, but is not limited to the specific examples given below.
The invention provides a composition, which comprises the following raw materials in parts by weight, 1-5 parts of a compound represented by the formula (1) and 2-5 parts of a stabilizer, wherein a buffer solution is used for supplementing the pH value to 6-7; the formula (1) is as follows:
wherein, X in the formula (1) is selected from any one of potassium, sodium, calcium and magnesium; r is selected from any one of hydrogen, C1-C5 alkoxy, C1-C5 alkyl, hydroxyl and carboxyl.
Preferably, R in the formula (1) is C1-C5 alkoxy; more preferably methoxy.
Preferably, X in the formula (1) is potassium.
In one embodiment, the stabilizer comprises ascorbic acid and/or a salt thereof.
Preferably, the stabilizer is ascorbic acid; further preferably, the ascorbic acid is selected from one or more of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid, 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid; more preferably, the ascorbic acid is 2-O-ethyl ascorbic acid.
Preferably, the weight ratio of the 2-O-ethyl ascorbic acid to the compound represented by the formula (1) is (0.5-1.2): 1; more preferably, the weight ratio of the 2-O-ethyl ascorbic acid to the compound represented by formula (1) is 0.75: 1.
the applicant finds that when X in formula (1) is potassium and R is methoxy, that is, 4-methoxysalicylate, the instability of 4-methoxysalicylate can cause the composition to be unstable, the composition can be discolored, and the whitening effect of the composition is affected, and the instability problem of 4-methoxysalicylate is solved in the following conventional ways: 1. pigments are added as masking agents, which usually cause unnecessary burden to the skin, and the problem of discoloration is not essentially solved; 2. the use amount of the 4-methoxy potassium salicylate is reduced, the essential problem is not solved, and the whitening efficiency of the whole formula is lowered; 3. the light stability of the 4-methoxy potassium salicylate can be improved by using sodium metabisulfite, but the substance cannot enhance the stability when the addition amount of the substance is less, the addition amount is more than 0.02 percent, and the substance is usually accompanied by unpleasant special smell; 4. benzophenone, ethylhexyl methoxycinnamate and other chemical sun-screening agents are added in the formula, and the substances are oil-soluble and are not easy to be added into a water-soluble formula; the substances have potential photosensitization and permeability, and influence the safety and the mildness of the formula; 5. the use of 3-O-ethyl ascorbic acid, improves the photostability of potassium 4-methoxysalicylate to some extent, but the degree of improvement is low, and a relatively low pH (less than 6) is required for the action, and under these conditions potassium 4-methoxysalicylate is easily decomposed. The applicant has unexpectedly found that when the stabilizer comprises ascorbic acid, and the ascorbic acid is 2-O-ethyl ascorbic acid, the weight ratio of the ascorbic acid to the compound represented by the formula (1) is (0.5-1.2): 1, the unstable problem brought by the formula (1) can be solved without reducing the whitening effect, and the applicant believes that the reason is that the 2-O-ethyl ascorbic acid can prevent the formula (1) from being oxidized under the conditions of illumination and oxygen, so that the oxidation product is prevented from being further polymerized, and the compound of the formula (1) can stably exert the whitening effect.
In one embodiment, the stabilizing agent further comprises a plant extract.
Preferably, the weight ratio of the plant extract to the ascorbic acid is (0.5-2): 1; more preferably, the weight ratio of the plant extract to ascorbic acid is 1: 1.
in one embodiment, the plant extract is selected from one or more of broadleaf holly leaf extract, angelica keiskei leaf extract, rosa roxburghii tratt extract, mangosteen pericarp extract, scutellaria baicalensis root extract, licorice root extract, angelica root extract, grape seed extract, green tea extract, and mulberry root extract.
Preferably, the plant extract is a broadleaf holly leaf extract.
The broadleaf holly leaf extract is purchased from Shanxi Xintianyuan Biotech limited company.
The applicant has surprisingly found that the stability of the composition can be further improved when the stabilizer also comprises a plant extract, in particular when the plant extract is an extract of broadleaf holly leaf, the applicant believes that a possible reason is that the broadleaf holly leaf extract has a high light absorption effect and 2-O-ethyl ascorbic acid has a synergistic effect, avoiding the polymerization of the composition after oxidation of the 4-methoxy potassium salicylate during use and storage.
In one embodiment, the buffer is selected from one or more of a lactic acid/sodium lactate buffer, a citric acid/sodium citrate buffer, a succinic acid/sodium succinate buffer, a citric acid/sodium hydroxide buffer.
The buffer solution is not particularly limited and may be selected by those skilled in the art as required.
The buffer solution is lactic acid/sodium lactate buffer solution.
The preparation of the lactic acid/sodium lactate buffer solution can be purchased or prepared by a conventional method.
In a second aspect, the present invention provides a method for preparing the composition, which comprises: mixing the raw materials of the composition.
In a third aspect of the invention, a skin care product comprising the composition is provided.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
The pH values described herein were all tested at 25 ℃.
Examples
Hereinafter, the present invention will be described in more detail by way of examples, but it should be understood that these examples are merely illustrative and not restrictive. The starting materials used in the examples which follow are all commercially available unless otherwise stated.
Example 1
Example 1 of the present invention provides a composition prepared from 2 parts by weight of the compound represented by formula (1), 1.5 parts by weight of a stabilizer, and a buffer to a pH of 7.0.
Wherein the content of the first and second substances,
the formula (1) is 4-methoxy potassium salicylate; the stabilizer is ascorbic acid and plant extracts in a weight ratio of 1:0.5, and the weight ratio of the ascorbic acid to the 4-methoxy potassium salicylate is 0.5: 1; the plant extract is a broadleaf holly leaf extract and is purchased from Shanxi Xintianyuan Biotech limited company; the ascorbic acid is 2-O-ethyl ascorbic acid.
The buffer solution is lactic acid/sodium lactate buffer solution.
The preparation method of the composition comprises the following steps: mixing the raw materials of the composition.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Example 2
Example 2 of the present invention provides a composition prepared from, by weight, 1 part of the compound represented by formula (1), 3 parts of a stabilizer, and a buffer to a pH of 7.0.
Wherein the content of the first and second substances,
the formula (1) is 4-methoxy sodium salicylate; the stabilizer is ascorbic acid and plant extract, the weight ratio of the ascorbic acid to the 4-methoxy sodium salicylate is 1:2, and the weight ratio of the ascorbic acid to the 4-methoxy sodium salicylate is 1: 1; the plant extract is a broadleaf holly leaf extract and is purchased from Shanxi Xintianyuan Biotech limited company; the ascorbic acid is 2-O-ethyl ascorbic acid.
The buffer solution is lactic acid/sodium lactate buffer solution.
The preparation method of the composition comprises the following steps: mixing the raw materials of the composition.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Example 3
Example 3 of the present invention provides a composition prepared from 2 parts by weight of the compound represented by formula (1), 3 parts by weight of a stabilizer, and a buffer to a pH of 7.0.
Wherein the content of the first and second substances,
the formula (1) is 4-methoxy sodium salicylate; the stabilizer is ascorbic acid and plant extract, the weight ratio of the ascorbic acid to the 4-methoxy sodium salicylate is 1:1, and the weight ratio of the ascorbic acid to the 4-methoxy sodium salicylate is 0.75: 1; the plant extract is a broadleaf holly leaf extract and is purchased from Shanxi Xintianyuan Biotech limited company; the ascorbic acid is 2-O-ethyl ascorbic acid.
The buffer solution is lactic acid/sodium lactate buffer solution.
The preparation method of the composition comprises the following steps: mixing the raw materials of the composition.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Example 4
Example 4 of the present invention provides a composition prepared from 2 parts by weight of the compound represented by formula (1), 1.2 parts by weight of a stabilizer, and a buffer to a pH of 7.0.
Wherein the content of the first and second substances,
the formula (1) is 4-methoxy sodium salicylate; the stabilizer is ascorbic acid and plant extract, the weight ratio of the ascorbic acid to the 4-methoxy sodium salicylate is 1:1, and the weight ratio of the ascorbic acid to the 4-methoxy sodium salicylate is 0.3: 1; the plant extract is a broadleaf holly leaf extract and is purchased from Shanxi Xintianyuan Biotech limited company; the ascorbic acid is 2-O-ethyl ascorbic acid.
The buffer solution is lactic acid/sodium lactate buffer solution.
The preparation method of the composition comprises the following steps: mixing the raw materials of the composition.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Example 5
Example 5 of the present invention provides a composition, which is similar to example 3, except that the plant extract is 0 part by weight.
The process for the preparation of the composition is as described in example 3.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Example 6
Example 6 of the present invention provides a composition according to the specific embodiment as in example 3, except that the ascorbic acid is 3-o-ethyl ascorbic acid.
The process for the preparation of the composition is as described in example 3.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Example 7
Example 7 of the present invention provides a composition according to the specific embodiment as in example 3, except that the ascorbic acid is replaced by sodium metabisulphite.
The process for the preparation of the composition is as described in example 3.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Example 8
Example 8 of the present invention provides a composition, which is similar to example 3, except that the plant extract is a mangosteen pericarp extract.
The process for the preparation of the composition is as described in example 3.
The composition is used in skin care products.
The skin care product comprises face cream, eye cream, face cleanser, facial mask, BB cream, essence, sunscreen cream, sunscreen water, face cleaning lotion, acne lotion, essential oil, shampoo, moisturizing water, toner, astringent and smoothing toner.
Performance evaluation
1. Stability: the compositions obtained in examples 1 to 8 were placed in a closed container and placed in an environment of high temperature of 50 ℃ for 12 months, and whether discoloration occurred or not was recorded every 4 months.
2. Odor: the compositions obtained in examples 1 to 8 were each recorded for the presence of pungent odor.
TABLE 1
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The composition is characterized in that the preparation raw materials comprise 1-5 parts by weight of a compound represented by the formula (1) and 2-5 parts by weight of a stabilizer, and a buffer solution is used for supplementing the pH value to 6-7; the stabilizer comprises ascorbic acid and/or a salt thereof; the formula (1) is as follows:
wherein, X in the formula (1) is selected from any one of potassium, sodium, calcium and magnesium; r is selected from any one of hydrogen, C1-C5 alkoxy, C1-C5 alkyl, hydroxyl and carboxyl.
2. The composition of claim 1, wherein the ascorbic acid is selected from the group consisting of one or more of 2-O- α -D-glucopyranosyl-L-ascorbic acid, 3-O-ethyl ascorbic acid, and 2-O-ethyl ascorbic acid.
3. The composition according to claim 1, wherein R in the formula (1) is a C1-C5 alkoxy group, preferably a methoxy group.
4. The composition of claim 3, wherein the ascorbic acid is 2-O-ethyl ascorbic acid.
5. The composition as claimed in any one of claims 1 to 4, wherein the stabilizer further comprises a plant extract in a weight ratio to ascorbic acid of (0.5 to 2): 1.
6. the composition as claimed in claim 5, wherein the plant extract is selected from one or more of Folum Ilicis extract, Angelica keiskei extract, Rosa roxburghii extract, Garcinia mangostana pericarp extract, Scutellaria baicalensis root extract, Glycyrrhiza glabra root extract, Angelica sinensis root extract, grape seed extract, Green tea extract, and Morus alba root extract.
7. The composition as claimed in any one of claims 1 to 4, wherein the buffer is selected from one or more of a lactic acid/sodium lactate buffer, a citric acid/sodium citrate buffer, a succinic acid/sodium succinate buffer, and a citric acid/sodium hydroxide buffer.
8. A process for preparing a composition according to any one of claims 1 to 7, characterized in that it comprises: mixing the raw materials of the composition.
9. A skin care product comprising a composition according to any one of claims 1 to 7.
10. The cosmetic composition according to claim 9, wherein the cosmetic composition comprises a cream, an eye cream, a face cleanser, a face mask, a BB cream, a serum, a sunscreen cream, a sunscreen lotion, a face cleanser, an acne cleanser, an essential oil, a shampoo, a moisturizer, a toner, an astringent and a toner.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010527933.1A CN111557876B (en) | 2020-06-11 | 2020-06-11 | Composition, skin care product and preparation method thereof |
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| CN202010527933.1A CN111557876B (en) | 2020-06-11 | 2020-06-11 | Composition, skin care product and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005120023A (en) * | 2003-10-16 | 2005-05-12 | Shiseido Co Ltd | Skin care preparation |
| JP2010189352A (en) * | 2009-02-20 | 2010-09-02 | Shiseido Co Ltd | Transdermal absorption promoting agent and external preparation for skin containing the same |
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2020
- 2020-06-11 CN CN202010527933.1A patent/CN111557876B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005120023A (en) * | 2003-10-16 | 2005-05-12 | Shiseido Co Ltd | Skin care preparation |
| JP2010189352A (en) * | 2009-02-20 | 2010-09-02 | Shiseido Co Ltd | Transdermal absorption promoting agent and external preparation for skin containing the same |
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