CN111556748A - 一种局部麻醉药物 - Google Patents

一种局部麻醉药物 Download PDF

Info

Publication number
CN111556748A
CN111556748A CN201880066945.XA CN201880066945A CN111556748A CN 111556748 A CN111556748 A CN 111556748A CN 201880066945 A CN201880066945 A CN 201880066945A CN 111556748 A CN111556748 A CN 111556748A
Authority
CN
China
Prior art keywords
alkyl group
dosage form
use according
ethyl
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201880066945.XA
Other languages
English (en)
Other versions
CN111556748B (zh
Inventor
张婧
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Yuejia Pharmaceuticals Co ltd
Original Assignee
Zhejiang Yuejia Pharmaceuticals Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Yuejia Pharmaceuticals Co ltd filed Critical Zhejiang Yuejia Pharmaceuticals Co ltd
Priority to CN202310496337.5A priority Critical patent/CN116270587A/zh
Publication of CN111556748A publication Critical patent/CN111556748A/zh
Application granted granted Critical
Publication of CN111556748B publication Critical patent/CN111556748B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

一种为通式1的化合物在制备局部麻醉药物中的应用，所述局部麻醉药物至少包含分离的固体部分与液体部分，所述的固体部分包括治疗有效量的通式1表示的化合物，所述的液体部分为药学上可接受的溶媒，所述局部麻醉药物在使用时，将所述固体部分与液体部分混合。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201880066945.XA 2017-11-17 2018-09-29 一种局部麻醉药物 Active CN111556748B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310496337.5A CN116270587A (zh) 2017-11-17 2018-09-29 一种局部麻醉药物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017111448072 2017-11-17
CN201711144807 2017-11-17
PCT/CN2018/108624 WO2019095879A1 (zh) 2017-11-17 2018-09-29 一种局部麻醉药物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202310496337.5A Division CN116270587A (zh) 2017-11-17 2018-09-29 一种局部麻醉药物

Publications (2)

Publication Number Publication Date
CN111556748A true CN111556748A (zh) 2020-08-18
CN111556748B CN111556748B (zh) 2023-04-14

Family

ID=66538827

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201880066945.XA Active CN111556748B (zh) 2017-11-17 2018-09-29 一种局部麻醉药物
CN202310496337.5A Pending CN116270587A (zh) 2017-11-17 2018-09-29 一种局部麻醉药物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202310496337.5A Pending CN116270587A (zh) 2017-11-17 2018-09-29 一种局部麻醉药物

Country Status (5)

Country Link
US (1) US11278513B2 (zh)
EP (1) EP3711753A4 (zh)
JP (1) JP2021503474A (zh)
CN (2) CN111556748B (zh)
WO (1) WO2019095879A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115448905B (zh) 2022-09-28 2023-06-09 浙江越甲药业有限公司 苯甲酸酯的衍生物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB736960A (en) * 1951-01-29 1955-09-14 Rheinpreussen Ag Esters of n-monoalkyl and n-monoalkoxyalkyl aminohydroxybenzoic acids
US2727039A (en) * 1953-10-09 1955-12-13 Sterling Drug Inc Tertiary-aminoalkyl 4-amino-2-hydroxy-benzoates, their salts and preparation thereof
US3365483A (en) * 1963-06-05 1968-01-23 Starogardzkie Zakl Farma Process for obtaining diethylaminoethanol acetylsalicylate hydrochloride
CN101484415A (zh) * 2006-07-09 2009-07-15 于崇曦 带有正电荷的水溶性阿司匹林前药
US20090238763A1 (en) * 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
CN102149673A (zh) * 2008-07-08 2011-08-10 凯特贝希制药公司 脂肪酸乙酰化的水杨酸酯及其用途

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB736960A (en) * 1951-01-29 1955-09-14 Rheinpreussen Ag Esters of n-monoalkyl and n-monoalkoxyalkyl aminohydroxybenzoic acids
US2727039A (en) * 1953-10-09 1955-12-13 Sterling Drug Inc Tertiary-aminoalkyl 4-amino-2-hydroxy-benzoates, their salts and preparation thereof
US3365483A (en) * 1963-06-05 1968-01-23 Starogardzkie Zakl Farma Process for obtaining diethylaminoethanol acetylsalicylate hydrochloride
CN101484415A (zh) * 2006-07-09 2009-07-15 于崇曦 带有正电荷的水溶性阿司匹林前药
US20090238763A1 (en) * 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
CN102149673A (zh) * 2008-07-08 2011-08-10 凯特贝希制药公司 脂肪酸乙酰化的水杨酸酯及其用途

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ARTHURC.COPE等: "Benzoates, p-aminobenzoates and phenylurethans of 2-alkylaminoethanols", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 *
SZADOWSKA, ANNA等: "The pharmacodynamic action of the hydrochloride of the diethylaminoethyl ester of acetylsalicylic acid", 《DISSERTATIONES PHARMACEUTICAE》 *
ZIPF, H. F.等: "Intravenous action of some local anesthetics on the sensitivity of the lung" *
ZIPF, H. F.等: "Intravenous and local action of local anesthetics on the impulses of the afferent heart nerves", 《NAUNYN-SCHMIEDEBERGS ARCHIV FUER PHARMAKOLOGIE UND EXPERIMENTELLE PATHOLOGIE》 *
南京药学院主编, 华中科技大学出版社 *

Also Published As

Publication number Publication date
EP3711753A1 (en) 2020-09-23
JP2021503474A (ja) 2021-02-12
US11278513B2 (en) 2022-03-22
EP3711753A4 (en) 2021-08-04
WO2019095879A1 (zh) 2019-05-23
US20200352896A1 (en) 2020-11-12
CN116270587A (zh) 2023-06-23
CN111556748B (zh) 2023-04-14

Similar Documents

Publication Publication Date Title
EP3438099B1 (en) Vortioxetine pamoic acid salt and crystal form thereof
EP3269719B1 (en) Crystal form of jak inhibitor and preparation method thereof
TWI657826B (zh) Complex of angiotensin II receptor antagonist metabolite and NEP inhibitor and preparation method thereof
CN110054624B (zh) 盐酸小檗碱与咖啡酸共晶物及制备方法和其组合物与用途
US11986453B2 (en) Stable pharmaceutical composition containing non-steroidal anti-inflammatory drug derivative
BRPI0610734A2 (pt) complexo de substáncia ativa estável do ácido o-acetilsalicìlico com aminoácidos básicos e glicina
ES2899367T3 (es) Forma amorfa de trifenatato de vilanterol y procedimientos para su preparación
JP2022503890A (ja) ２－（１－アシルオキシ－ｎ－ペンチル）安息香酸と塩基性アミノ酸またはアミノグアニジンによって形成される塩と、その製造方法及び用途
CN111825547B (zh) 一种芳基丙酸类化合物的盐及其制药用途
CN110041326B (zh) 盐酸小檗碱与反丁烯二酸共晶物及制备方法和其组合物与用途
CN111556748B (zh) 一种局部麻醉药物
CN110041325B (zh) 盐酸小檗碱与布洛芬共晶物及制备方法和其组合物与用途
JP2011529859A (ja) プラスグレル重硫酸塩及びその薬物組成物並びにその応用
WO2019011350A1 (zh) 芬乐胺晶g型、制备方法和其组合物与用途
ES2298358T3 (es) Cristales de tosilato de suplatast.
CN113943284B (zh) 盐酸吡格列酮没食子酸共晶及制备方法和其组合物与用途
ES2970120T3 (es) Sal de potasio monohidratada de un derivado de tienopiridona y su proceso de preparación
CN109651253B (zh) 苯丙烯酸酯衍生物及其作为神经保护药物的应用
CN105367622B (zh) 一种阿加曲班化合物
BRPI0416006B1 (pt) composições farmacêuticas com base em um sal de idazoxano,comprimidos,processo para fabricação dos mesmos e usos das referidas composições
CN113943283B (zh) 盐酸吡格列酮对氨基苯甲酸共晶及制备和其组合物与用途
US9937262B2 (en) Prodrugs of naproxen and diclofenac
WO2022001889A1 (zh) 去甲曲马多的盐及其用途
CN113943282A (zh) 盐酸吡格列酮对氨基水杨酸共晶及制备方法和其组合物与用途
JP2016504358A (ja) オキシブチニンを投与するための方法および組成物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant