CN111544558A - External application patch for treating numbness of hand and foot nerves and preparation method thereof - Google Patents

External application patch for treating numbness of hand and foot nerves and preparation method thereof Download PDF

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Publication number
CN111544558A
CN111544558A CN202010426897.XA CN202010426897A CN111544558A CN 111544558 A CN111544558 A CN 111544558A CN 202010426897 A CN202010426897 A CN 202010426897A CN 111544558 A CN111544558 A CN 111544558A
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China
Prior art keywords
herba
patch
hand
nerves
numbness
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Pending
Application number
CN202010426897.XA
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Chinese (zh)
Inventor
王载忠
刘辉
周莎莎
杨扬
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Zhumadian Central Hospital
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Zhumadian Central Hospital
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Priority to CN202010426897.XA priority Critical patent/CN111544558A/en
Publication of CN111544558A publication Critical patent/CN111544558A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

Abstract

The invention discloses an external application patch for treating numbness of hand and foot nerves and a preparation method thereof, and the external application patch is prepared from garden balsam stem, siegesbeckia herb, safflower, parasitic loranthus, lycopodium clavatum, dried ginger, artemisia capillaries, Japanese ardisia, horehound herb, erythrina bark, beautiful sweetgum fruit, red paeony root, spiced sargentgloryvine stem and white spirit. Compared with the prior art, the external ointment prepared by adopting the pure Chinese medicinal preparation has no chemical agent and no side effect on human body, is pasted on the back neck and the parts above the buttocks when in use, effectively diminishes inflammation and relieves pain, relaxes the channels and activates the collaterals, can quickly treat the deadlimb caused by the oppression on the brothers and soles, can quickly eliminate the deadlimb and pain of the brothers and soles by matching with physical therapy, and has popularization and application values.

Description

External application patch for treating numbness of hand and foot nerves and preparation method thereof
Technical Field
The invention relates to an external application medicament, in particular to an external application patch for treating numbness of hand and foot nerves and a preparation method thereof.
Background
Hand and foot numbness is an independent disease of limb motor nerve damage, and is mostly caused by stroke paralysis, diabetes, neuritis, cervical spondylosis, rheumatism, rheumatoid disease, vasculitis and other isosceles spondylosis, and the motor nerve fibers are seriously damaged due to the blockage of tiny blood vessels around the motor nerve fibers and the compression of the motor fibers. The conduction ability and conduction speed of nerves are reduced, and hand and foot numbness occurs. A severe person may develop quadriplegia. Muscular atrophy and other painful symptoms. The diseases usually occur in the middle-aged and the elderly, or patients with bone joint surgery and injury. In the prior art, most of schemes for treating the numbness of the hand and foot nerves are physiotherapy and acupuncture, but the curative effect is slow, so that the improvement space exists.
Disclosure of Invention
The invention aims to solve the problems and provide an external patch for treating numbness of hand and foot nerves and a preparation method thereof.
The invention realizes the purpose through the following technical scheme:
the invention relates to an external application patch for treating numbness of hand and foot nerves, which is prepared from garden balsam stem, herba siegesbeckiae, safflower, Chinese taxillus twig, common clubmoss herb, dried ginger, artemisia capillaries, Japanese milkwort herb, selfheal, erythrina bark, beautiful sweetgum fruit, red paeony root, spiced sargentgloryvine stem and white spirit.
Preferably, each part contains 9% of garden balsam stem, 7% of siegesbeckia orientalis, 7% of safflower, 8% of parasitic loranthus, 9% of lycopodium clavatum, 8% of dried ginger, 6% of artemisia capillaris, 8% of Japanese ardisia root bark, 3% of common selfheal herb, 5% of erythrina bark, 7% of beautiful sweetgum fruit, 7% of red peony root, 6% of kadsura pepper stem and 10% of white spirit according to the weight ratio.
Preferably, the alcohol is medical alcohol with a degree of 90 or more.
The preparation method of the external patch for treating the numbness of the hand and foot nerves comprises the following steps:
s1: weighing caulis et folium Gaultheriae Yunnanensis, Siegesbeckiae herba, Carthami flos, herba Taxilli, herba Lycopodii, Zingiberis rhizoma, herba Artemisiae Scopariae, cortex Tripterygii Hypoglauci, herba Equiseti Arvinsis, cortex Erythrinae, fructus Lipuidambaris, radix Paeoniae Rubra, and caulis Kadsurae Longipedunculatae in proportion, crushing, and mixing to obtain mixture;
s2: steaming the obtained mixture in a pot;
s3: maintaining the fermentation temperature of the mixture at 35-40 deg.C;
s4: after fermenting for 8-10 days, adding alcohol, stirring uniformly, and pressing into a post-fermentation tank to refine the fermented grains;
s5: standing for 4-5 months to obtain topical patch for treating numbness of hand and foot nerves;
s6: placing the obtained patch in the middle of medical adhesive plaster to obtain the final product.
The invention has the beneficial effects that:
the invention relates to an external application patch for treating the numbness of the hand-foot nerves and a preparation method thereof, compared with the prior art, the external application patch is prepared by adopting a pure Chinese medicinal preparation, has no chemical agent and no side effect on human bodies, is pasted on the back neck and the parts above the buttocks when in use, effectively diminishes inflammation and relieves pain, relaxes channels and activates collaterals, can quickly treat the numbness of the hand-foot caused by the oppression of the hand-foot nerves, can more quickly eliminate the numbness and pain of the hand-foot nerves by matching with physical therapy, and has popularization and application values.
Detailed Description
The invention is further illustrated below:
the invention relates to an external application patch for treating numbness of hand and foot nerves, which is prepared from garden balsam stem, herba siegesbeckiae, safflower, Chinese taxillus twig, common clubmoss herb, dried ginger, artemisia capillaries, Japanese milkwort herb, selfheal, erythrina bark, beautiful sweetgum fruit, red paeony root, spiced sargentgloryvine stem and white spirit.
Preferably, each part contains 9% of garden balsam stem, 7% of siegesbeckia orientalis, 7% of safflower, 8% of parasitic loranthus, 9% of lycopodium clavatum, 8% of dried ginger, 6% of artemisia capillaris, 8% of Japanese ardisia root bark, 3% of common selfheal herb, 5% of erythrina bark, 7% of beautiful sweetgum fruit, 7% of red peony root, 6% of kadsura pepper stem and 10% of white spirit according to the weight ratio.
Preferably, the alcohol is medical alcohol with a degree of 90 or more.
The preparation method of the external patch for treating the numbness of the hand and foot nerves comprises the following steps:
s1: weighing caulis et folium Gaultheriae Yunnanensis, Siegesbeckiae herba, Carthami flos, herba Taxilli, herba Lycopodii, Zingiberis rhizoma, herba Artemisiae Scopariae, cortex Tripterygii Hypoglauci, herba Equiseti Arvinsis, cortex Erythrinae, fructus Lipuidambaris, radix Paeoniae Rubra, and caulis Kadsurae Longipedunculatae in proportion, crushing, and mixing to obtain mixture;
s2: steaming the obtained mixture in a pot;
s3: maintaining the fermentation temperature of the mixture at 35-40 deg.C;
s4: after fermenting for 8-10 days, adding alcohol, stirring uniformly, and pressing into a post-fermentation tank to refine the fermented grains;
s5: standing for 4-5 months to obtain topical patch for treating numbness of hand and foot nerves;
s6: placing the obtained patch in the middle of medical adhesive plaster to obtain the final product.
The antiallergic experiment of the invention comprises the following steps: white guinea pigs weighing 250-300g were used in total of 10 animals. The hair on the back of the guinea pig is removed before the test, the patch of the present invention is uniformly applied to the depilated part on the back on the 1 st day, the 7 th day and the 14 th day of the test, the skin reaction condition is observed once per hour after 10 minutes, and the patch is used once again on the 21 st day, and the method is the same as the method, and the skin has or does not have anaphylactic reaction. The experimental result is scored according to the skin reaction standard, the reaction degree is judged according to the reaction difference, the average reaction value of 10 animals is zero (the total of erythema and edema formation is zero), and the sensitization rate is also zero. The conclusion is that the product belongs to a non-sensitizing medicament.
Pain-relieving test, 10 white guinea pigs, mice with depilatory patch on the back for 48 hours, intraperitoneal acetic acid injection, recording and comparing the number of writhing times of mice within 15 minutes, and determining the inhibition rate. The results prove that: the inhibition ratio of the invention is 62.7%.
The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (4)

1. An externally applied patch for treating numbness of hand and foot nerves is characterized in that: is prepared from herba Speranskiae Tuberculatae, Siegesbeckiae herba, Carthami flos, herba Taxilli, herba Lycopodii, Zingiberis rhizoma, herba Artemisiae Scopariae, cortex Tripterygii Hypoglauci Radicis, herba Equiseti Arvinsis, cortex Erythrinae, fructus Lipuidambaris, radix Paeoniae Rubra, caulis Kadsurae Longipedunculatae, and Chinese liquor.
2. The external patch for treating numbness of the palmar and plantar nerves according to claim 1, characterized in that: according to the weight ratio, each part contains 9% of garden balsam stem, 7% of siegesbeckia herb, 7% of safflower, 8% of loranthus parasiticus, 9% of lycopodium clavatum, 8% of dried ginger, 6% of artemisia capillaries, 8% of Japanese ardisia root bark, 3% of common selfheal herb, 5% of erythrina bark, 7% of beautiful sweetgum fruit, 7% of red paeony root, 6% of spiced caulis spatholobi and 10% of white spirit.
3. The external patch for treating numbness of the palmar and plantar nerves according to claim 2, characterized in that: the alcohol is medical alcohol with the alcohol content of more than 90 degrees.
4. A preparation method of an externally applied patch for treating numbness of hand and foot nerves is characterized in that: the method comprises the following steps:
s1: weighing caulis et folium Gaultheriae Yunnanensis, Siegesbeckiae herba, Carthami flos, herba Taxilli, herba Lycopodii, Zingiberis rhizoma, herba Artemisiae Scopariae, cortex Tripterygii Hypoglauci, herba Equiseti Arvinsis, cortex Erythrinae, fructus Lipuidambaris, radix Paeoniae Rubra, and caulis Kadsurae Longipedunculatae in proportion, crushing, and mixing to obtain mixture;
s2: steaming the obtained mixture in a pot;
s3: maintaining the fermentation temperature of the mixture at 35-40 deg.C;
s4: after fermenting for 8-10 days, adding alcohol, stirring uniformly, and pressing into a post-fermentation tank to refine the fermented grains;
s5: standing for 4-5 months to obtain topical patch for treating numbness of hand and foot nerves;
s6: placing the obtained patch in the middle of medical adhesive plaster to obtain the final product.
CN202010426897.XA 2020-05-19 2020-05-19 External application patch for treating numbness of hand and foot nerves and preparation method thereof Pending CN111544558A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010426897.XA CN111544558A (en) 2020-05-19 2020-05-19 External application patch for treating numbness of hand and foot nerves and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010426897.XA CN111544558A (en) 2020-05-19 2020-05-19 External application patch for treating numbness of hand and foot nerves and preparation method thereof

Publications (1)

Publication Number Publication Date
CN111544558A true CN111544558A (en) 2020-08-18

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587442A (en) * 2015-02-12 2015-05-06 上海市闸北区中医医院 Foot bath traditional Chinese medicine composition for treating wind-cold-dampness arthralgia and application of foot bath traditional Chinese medicine composition
CN105169246A (en) * 2015-09-11 2015-12-23 徐学军 Medicine for treating deadlimb
CN106963937A (en) * 2017-05-16 2017-07-21 林明芳 A kind of shoulder and neck external application formula
CN107050400A (en) * 2017-06-29 2017-08-18 荆州市顿美医药有限公司 Traditional Chinese medicinal liquor is smeared in one kind massage
CN108159174A (en) * 2016-12-06 2018-06-15 陆洲 It is a kind of to treat numb in every limb Chinese medicine fuming-lotion

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587442A (en) * 2015-02-12 2015-05-06 上海市闸北区中医医院 Foot bath traditional Chinese medicine composition for treating wind-cold-dampness arthralgia and application of foot bath traditional Chinese medicine composition
CN105169246A (en) * 2015-09-11 2015-12-23 徐学军 Medicine for treating deadlimb
CN108159174A (en) * 2016-12-06 2018-06-15 陆洲 It is a kind of to treat numb in every limb Chinese medicine fuming-lotion
CN106963937A (en) * 2017-05-16 2017-07-21 林明芳 A kind of shoulder and neck external application formula
CN107050400A (en) * 2017-06-29 2017-08-18 荆州市顿美医药有限公司 Traditional Chinese medicinal liquor is smeared in one kind massage

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
张思胜等: "中西医结合治疗骨间背侧神经卡压综合征(附14例报道)", 《深圳中西医结合杂志》 *
解脱之道: "麻木（多发性神经炎）中医诊疗方案", 《个人图书馆》 *
詹运开等: "综合治疗神经根型颈椎病20例", 《湖南中医杂志》 *

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