CN111544397A - Preparation method of cartoon type medicine for enhancing immunity of children - Google Patents
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- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a preparation method of a cartoon type medicine for treating emaciation with yellowish complexion, tiredness, anorexia and easy cold of children and enhancing the immunity of organisms. The invention adopts modern new microwave vacuum drying patent technology, extracts of medicinal materials are subjected to microwave vacuum separation to obtain water, the separated effective dry extracts are crushed into fine powder, xylitol, sorbitol, mannitol, lactose and trace edible essence are properly added to press the fine powder into medicine blocks with different shapes and colors, such as bear, tiger, elephant and the like, the image of the traditional Chinese medicine is changed, the feeling of the children for using the medicine is enhanced, and the effectiveness and compliance of the children patients for using the medicine can be greatly improved.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a preparation method of a cartoon type medicine for treating emaciation with yellowish complexion, tiredness, anorexia and easy cold of children and enhancing the immunity of organisms.
Background
The low immunity of children is generally related to dietary nutrition, change of living environment, emotion and other factors. Most children lack nutrition due to food preference or food picking, especially anemia, and the obvious decline of resistance of the children, and the relative small outdoor activities and the relative poor physique of the children are easy to cause. The physical exercise can be properly paid attention to at ordinary times to improve the immunity of children, the normal diet is paid attention to at night, the psychological pressure is not too great for relaxing the mood, and the selection of the nutritional health care products can be considered to exercise the body and pay attention to the diet.
If children are weak and sick, the low resistance means that the children are easily affected by various diseases and the like, the children have poor resistance, and the children are often affected by various adverse factors, such as chronic rhinitis, repeated cold, repeated inflammation of tonsillitis and the like, which are all manifestations of low immunity and poor resistance, so that the health of the children is affected, and the normal growth and development of the children are easily affected after long-term use.
The Upper Respiratory Tract Infection (URTIs) is the most common type of common cold, and symptoms such as sneezing, nasal obstruction, watery nasal discharge, pharyngeal congestion and the like are often caused during alternate seasons, particularly in winter and spring, and the lasting time is 7-10 days. The infant patient may also have lacrimation, slow taste, poor breathing, cough, small amount of expectoration, etc., and the general symptoms are mild, fever is not obvious or only low heat is present.
The functions of infant liver detoxification, kidney excretion and the like are not well developed, adverse reactions are easily caused by improper medication, and even the harm to health is more serious than the disease per se. Therefore, the traditional Chinese medicine has important effects of regulating the spleen and stomach functions of children, enhancing the appetite of the children, enhancing the resistance of the children and reducing the cold times of the children.
The medicine is prepared from radix astragali, Atractylodis rhizoma, radix Saposhnikoviae, rhizoma Phragmitis, endothelium corneum Gigeriae Galli, Poria, and rhizoma Dioscoreae. Has the effects of benefiting qi, strengthening exterior, strengthening middle-jiao and invigorating spleen, can be used for treating symptoms of tiredness, anorexia, emaciation with sallow complexion, dysphoria, exterior deficiency, spontaneous perspiration, susceptibility to wind evil and the like caused by spleen-lung qi deficiency of children, and can obviously and effectively improve the immunity and enhance the resistance of children. The medicine is added and subtracted on the basis of the famous formula of Yupingfengsan in the modern, and is clinically verified for many years.
The chemical components of the traditional Chinese medicine are quite complex, and not only contain various effective components, but also have ineffective components and possibly contain toxic components. The extraction of the effective components, the further separation and purification of the effective components to obtain the high-purity effective body is an important content in the research field of traditional Chinese medicines. The extraction of the traditional Chinese medicine is to extract the effective components in the traditional Chinese medicine to the maximum extent by utilizing certain technologies, so that the internal quality and the clinical treatment effect of the traditional Chinese medicine preparation are improved, and the effect of the traditional Chinese medicine is exerted to the maximum extent. Meanwhile, the medicine mainly aims at children, and the problem to be solved by the invention is how to enable children to accept the medicine better. The extraction and separation of the medicine adopt a microwave vacuum drying technology, which is a novel microwave energy application technology combining a microwave energy technology and a vacuum technology, and has a series of advantages of microwave and vacuum drying, so that moisture can be volatilized at low temperature through intermolecular vibration without damaging effective components, volatilization of water molecules can be accelerated in a vacuum mode, the components are saved to the maximum extent, and the defects of long period and low efficiency of conventional vacuum drying are overcome. Has the advantages of high separation efficiency, good quality, low cost, good product taste and the like. Aiming at the defects of large administration dosage, bitter taste and single appearance of the traditional Chinese medicine which is difficult to be accepted by children, the medicine is properly added with xylitol, sorbitol, mannitol, lactose and trace edible essence in the effective components and pressed into medicine blocks with different shapes and colors, such as bear, tiger, elephant and the like, so that the image of the traditional Chinese medicine is changed, and the medicine feeling of children is enhanced.
Disclosure of Invention
Aiming at the defects existing in the existing traditional Chinese medicine preparation, the invention adopts the novel patented technology of microwave vacuum drying to carry out low-temperature rapid moisture separation on the extract, and the obtained medicine is crushed and then granulated, so that compared with the traditional extract granulation mode, the use amount of auxiliary materials is greatly reduced, the taking volume is reduced, and the dissolubility is improved, thereby reducing the loss of effective components, and simultaneously improving the taste, and the effectiveness and the compliance of the medicine taking of children patients can be greatly improved by combining different cartoon appearances of little bears, elephants, tigers and the like.
On one hand, the invention provides a preparation method of Baoenning granules, which comprises the steps of (1) crushing 1 part of bighead atractylodes rhizome and 1-2 parts of divaricate saposhnikovia root into coarse powder, soaking twice in 75% ethanol for 12 hours each time, merging filtrates, and concentrating under reduced pressure to obtain clear paste with the relative density of 1.10-1.15 (70-80 ℃); (2) decocting the immersed dregs, 2 parts of astragalus, 2 parts of reed rhizome, 1-2 parts of tuckahoe and 2 parts of yam in water twice for 2 hours for the first time and 1.5 hours for the second time, mixing the decoctions, filtering, concentrating the filtrate to a proper amount, adding equal-time ethanol, standing for precipitation, filtering, recovering the ethanol from the filtrate, and concentrating to a proper amount; (3) pulverizing endothelium corneum Gigeriae Galli into coarse powder, adding water, heating to slightly boil, maintaining the temperature for 1 hr, filtering, extracting the residue with the same method, mixing filtrates, and concentrating the filtrate under reduced pressure to appropriate amount; (4) mixing the above extracts, and concentrating under reduced pressure to obtain extract with relative density of 1.30-1.35 (60 deg.C); (5) microwave vacuum drying, wherein the parameters of the microwave vacuum drying are as follows: 2450MHz plus or minus 50Hz, heating at 40-55 deg.C, and vacuum-0.08 MPa, and drying 50kg of fluid extract with relative density of 1.35 (60 deg.C) for 45 min; the main effective component of radix astragali is not less than 0.01% calculated by astragaloside IV; and (4) crushing.
On the other hand: the invention also provides a process for further pressing the dry extract powder into cartoon type blocks, 1) crushing the white atractylodes rhizome and the divaricate saposhnikovia root into coarse powder, soaking the coarse powder twice in 75% ethanol for 12 hours each time, merging filtrate, and concentrating the filtrate under reduced pressure to obtain clear paste with the relative density of 1.10-1.15 (70-80 ℃); (2) decocting the residue, radix astragali, rhizoma Phragmitis, Poria, and rhizoma Dioscoreae in water twice (2 hr for the first time and 1.5 hr for the second time), mixing decoctions, filtering, concentrating the filtrate to appropriate amount, adding equal amount of ethanol, standing for precipitation, filtering, recovering ethanol from the filtrate, and concentrating to appropriate amount; (3) pulverizing endothelium corneum Gigeriae Galli into coarse powder, adding water, heating to slightly boil, maintaining the temperature for 1 hr, filtering, extracting the residue with the same method, mixing filtrates, and concentrating the filtrate under reduced pressure to appropriate amount; (4) mixing the above extracts, and concentrating under reduced pressure to obtain extract with relative density of 1.30-1.35 (60 deg.C); (5) microwave vacuum drying, wherein the parameters of the microwave vacuum drying are as follows: 2450MHz + -50 Hz, heating at 60-70 deg.C, and vacuum-0.08 MPa, wherein the fluid extract has relative density of 1.35 (60 deg.C) and is dried for 45 min; the main effective component of radix astragali is not less than 0.32mg calculated by astragaloside IV; crushing; (6) or adding xylitol, sorbitol, mannitol, lactose and trace edible essence, pressing into different shapes and colors, wherein the content of radix astragali in the main effective component is not less than 0.1mg (calculated as astragaloside IV); .
The block is in a cartoon shape which is easily accepted by children, and the images of a bear, a tiger and a elephant are preferred.
The invention has the advantages of
The extract after the medicine is extracted changes the original traditional mode of adding auxiliary materials for granulation, but adopts microwave vacuum heating to dry the extract, greatly reduces the volume of the extract, reduces the loss of effective components, saves energy, can also improve the drying efficiency, improves the product quality and improves the taste; the extract is dried and crushed, and then xylitol, sorbitol, mannitol, lactose and trace edible essence are added for mixing and granulating, so that the traditional Chinese medicine can be effectively improved in large volume, bitter taste and black color, and the cartoon-shaped appearance is supplemented, thereby overcoming the psychological barrier of children in medication and improving the medication dependence.
Example (b):
example 1:
98g of bighead atractylodes rhizome and 139g of divaricate saposhnikovia root are crushed into coarse powder, the coarse powder is soaked twice in 75 percent ethanol for 12 hours each time, the filtrates are combined and concentrated under reduced pressure to obtain clear paste with the relative density of 1.10-1.15 (70-80 ℃); (2) mixing the residue with 198g radix astragali, 196g rhizoma Phragmitis, 137g Poria and 196g rhizoma Dioscoreae, decocting in water for 2 hr and 1.5 hr, mixing decoctions, filtering, concentrating the filtrate, adding equal-fold ethanol, standing for precipitation, filtering, recovering ethanol from the filtrate, and concentrating to appropriate amount; (3) pulverizing endothelium corneum Gigeriae Galli into coarse powder, adding water, heating to slightly boil, maintaining the temperature for 1 hr, filtering, extracting the residue with the same method, mixing filtrates, and concentrating the filtrate under reduced pressure to appropriate amount; (4) mixing the above extracts, and concentrating under reduced pressure to obtain extract with relative density of 1.30-1.35 (60 deg.C); (5) microwave vacuum drying, wherein the microwave vacuum drying parameters are as follows: microwave frequency: 2450MHz + -50 Hz, heating at 60 deg.C, and vacuum-0.08 MPa, wherein the fluid extract has relative density of 1.35 (60 deg.C) and is dried for 45 min; crushing, granulating and drying; (6) or adding xylitol, sorbitol, mannitol, lactose and trace edible essence, and pressing into medicinal blocks with different shapes and colors, wherein the content of radix astragali in the main effective component is not less than 0.1 mg.
Example 2:
98g of bighead atractylodes rhizome and 139g of divaricate saposhnikovia root are crushed into coarse powder, the coarse powder is soaked twice in 75 percent ethanol for 12 hours each time, the filtrates are combined and concentrated under reduced pressure to obtain clear paste with the relative density of 1.10-1.15 (70-80 ℃); (2) mixing the residue with 198g radix astragali, 196g rhizoma Phragmitis, 137g Poria and 196g rhizoma Dioscoreae, decocting in water for 2 hr and 1.5 hr, mixing decoctions, filtering, concentrating the filtrate, adding equal-fold ethanol, standing for precipitation, filtering, recovering ethanol from the filtrate, and concentrating to appropriate amount; (3) pulverizing endothelium corneum Gigeriae Galli into coarse powder, adding water, heating to slightly boil, maintaining the temperature for 1 hr, filtering, extracting the residue with the same method, mixing filtrates, and concentrating the filtrate under reduced pressure to appropriate amount; (4) mixing the above extracts, and concentrating under reduced pressure to obtain extract with relative density of 1.30-1.35 (60 deg.C); (5) microwave vacuum drying, wherein the microwave vacuum drying parameters are as follows: drying the fluid extract with relative density of 1.35 (60 deg.C) for 60min under the conditions of microwave heating temperature of 70 deg.C and vacuum of-0.08 MPa; crushing, granulating and drying; (6 adding xylitol, sorbitol, mannitol, lactose and trace edible essence, and pressing into medicinal blocks with different shapes and colors, wherein the content of radix astragali in the main effective component is not less than 0.1 mg.
Claims (2)
1. A method for preparing a baoenning granule, the method comprising:
(1) 1 part of bighead atractylodes rhizome and 1-2 parts of divaricate saposhnikovia root are crushed into coarse powder, the coarse powder is soaked twice in 75% ethanol for 12 hours each time, the filtrates are combined and concentrated under reduced pressure to obtain clear paste with the relative density of 1.10-1.15 (70-80 ℃);
(2) decocting the immersed dregs, 2 parts of astragalus, 2 parts of reed rhizome, 1-2 parts of tuckahoe and 2 parts of yam in water twice for 2 hours for the first time and 1.5 hours for the second time, mixing the decoctions, filtering, concentrating the filtrate to a proper amount, adding equal-time ethanol, standing for precipitation, filtering, recovering the ethanol from the filtrate, and concentrating to a proper amount;
(3) pulverizing endothelium corneum Gigeriae Galli into coarse powder, adding water, heating to slightly boil, maintaining the temperature for 1 hr, filtering, extracting the residue with the same method, mixing filtrates, and concentrating the filtrate under reduced pressure to appropriate amount;
(4) mixing the above extracts, and concentrating under reduced pressure to obtain extract with relative density of 1.30-1.35 (60 deg.C);
(5) microwave vacuum drying, wherein the parameters of the microwave vacuum drying are as follows: 2450MHz plus or minus 50Hz, heating at 40-55 deg.C, and vacuum-0.08 MPa, and drying 50kg of fluid extract with relative density of 1.35 (60 deg.C) for 45 min; the main effective component of radix astragali is not less than 0.01% calculated by astragaloside IV; and (4) crushing.
2. The process for the preparation of a baoenning block as claimed in claim 1, wherein magnesium stearate may or may not be further added and the block biscuit is obtained by briquetting.
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| CN202010526229.4A CN111544397A (en) | 2020-06-11 | 2020-06-11 | Preparation method of cartoon type medicine for enhancing immunity of children |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113662858A (en) * | 2021-08-25 | 2021-11-19 | 首都医科大学宣武医院 | Intelligent medicine taking prompting system and method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718335A (en) * | 2017-10-27 | 2019-05-07 | 江苏颐海药业有限责任公司 | The preparation method of the peaceful block of guarantor for hired help |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109718335A (en) * | 2017-10-27 | 2019-05-07 | 江苏颐海药业有限责任公司 | The preparation method of the peaceful block of guarantor for hired help |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113662858A (en) * | 2021-08-25 | 2021-11-19 | 首都医科大学宣武医院 | Intelligent medicine taking prompting system and method |
| CN113662858B (en) * | 2021-08-25 | 2024-03-29 | 首都医科大学宣武医院 | Intelligent medicine taking prompt system and method |
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Application publication date: 20200818 |
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