CN1115417C - 用于制备氨苄青霉素的方法 - Google Patents

用于制备氨苄青霉素的方法 Download PDF

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Publication number
CN1115417C
CN1115417C CN98807876A CN98807876A CN1115417C CN 1115417 C CN1115417 C CN 1115417C CN 98807876 A CN98807876 A CN 98807876A CN 98807876 A CN98807876 A CN 98807876A CN 1115417 C CN1115417 C CN 1115417C
Authority
CN
China
Prior art keywords
apa
concentration
ampicillin
phenylglycine derivatives
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN98807876A
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English (en)
Chinese (zh)
Other versions
CN1265706A (zh
Inventor
H·M·莫迪
W·H·J·贝特森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centrient Pharmaceuticals Netherlands BV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Publication of CN1265706A publication Critical patent/CN1265706A/zh
Application granted granted Critical
Publication of CN1115417C publication Critical patent/CN1115417C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CN98807876A 1997-06-10 1998-05-25 用于制备氨苄青霉素的方法 Expired - Lifetime CN1115417C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1006266A NL1006266C2 (nl) 1997-06-10 1997-06-10 Werkwijze voor de bereiding van ampicilline.
NL1006266 1997-06-10

Publications (2)

Publication Number Publication Date
CN1265706A CN1265706A (zh) 2000-09-06
CN1115417C true CN1115417C (zh) 2003-07-23

Family

ID=19765126

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98807876A Expired - Lifetime CN1115417C (zh) 1997-06-10 1998-05-25 用于制备氨苄青霉素的方法

Country Status (12)

Country Link
US (1) US7029885B2 (cg-RX-API-DMAC10.html)
EP (1) EP0988393B1 (cg-RX-API-DMAC10.html)
KR (1) KR100508290B1 (cg-RX-API-DMAC10.html)
CN (1) CN1115417C (cg-RX-API-DMAC10.html)
AT (1) ATE319849T1 (cg-RX-API-DMAC10.html)
AU (1) AU7677798A (cg-RX-API-DMAC10.html)
BR (1) BR9810020A (cg-RX-API-DMAC10.html)
ES (1) ES2258298T3 (cg-RX-API-DMAC10.html)
IN (1) IN186863B (cg-RX-API-DMAC10.html)
NL (1) NL1006266C2 (cg-RX-API-DMAC10.html)
TR (1) TR200000201T2 (cg-RX-API-DMAC10.html)
WO (1) WO1998056946A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538045B1 (en) * 1999-12-23 2003-03-25 Dsm N.V. Optical fiber coating compositions containing secondary or tertiary amino silicone-containing additive
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
ES2729707T3 (es) 2011-06-23 2019-11-05 Centrient Pharmaceuticals Netherlands B V Proceso de preparación de cefalosporinas 3'-tiosustituidas empleando una penicilina G acilasa

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001061A1 (en) * 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2188608A5 (en) * 1972-06-14 1974-01-18 Aries Robert Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
IT1243800B (it) * 1990-08-28 1994-06-28 Sclavo Spa Procedimento migliorato per la preparazione di cefalosporine
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
US6048708A (en) * 1994-07-18 2000-04-11 Gist-Brocades B.V. Process for preparation of β-lactams at constantly high concentration of reactants
NL1007076C2 (nl) 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007077C2 (nl) 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007302C2 (nl) 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001061A1 (en) * 1990-07-04 1992-01-23 Novo Nordisk A/S PROCESS FOR PREPARATION OF β-LACTAMS
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin

Also Published As

Publication number Publication date
KR20010013635A (ko) 2001-02-26
CN1265706A (zh) 2000-09-06
US7029885B2 (en) 2006-04-18
IN186863B (cg-RX-API-DMAC10.html) 2001-11-24
WO1998056946A1 (en) 1998-12-17
AU7677798A (en) 1998-12-30
EP0988393A1 (en) 2000-03-29
TR200000201T2 (tr) 2000-06-21
ATE319849T1 (de) 2006-03-15
US20020009769A1 (en) 2002-01-24
KR100508290B1 (ko) 2005-08-17
ES2258298T3 (es) 2006-08-16
NL1006266C2 (nl) 1998-12-14
EP0988393B1 (en) 2006-03-08
BR9810020A (pt) 2000-09-19

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C06 Publication
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SE01 Entry into force of request for substantive examination
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Owner name: DSMIP PROPERTY CO., LTD.

Free format text: FORMER OWNER: DSM N. V.

Effective date: 20040618

C41 Transfer of patent application or patent right or utility model
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Effective date of registration: 20040618

Address after: Holland Heerlen

Patentee after: DSMIP Property N. V.

Address before: Holland Heerlen

Patentee before: DSM N. V.

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Owner name: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.

Free format text: FORMER OWNER: DSM IP PROPERTY GMBH

Effective date: 20120214

C41 Transfer of patent application or patent right or utility model
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Effective date of registration: 20120214

Address after: About Holland

Patentee after: DSM Sinochem Pharmaceuticals Netherlands B V

Address before: Holland Heerlen

Patentee before: DSM IP Property Limited

CX01 Expiry of patent term

Granted publication date: 20030723

CX01 Expiry of patent term