CN111533796A - 用于癌症免疫治疗的肽及其肽组合物 - Google Patents

用于癌症免疫治疗的肽及其肽组合物 Download PDF

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Publication number
CN111533796A
CN111533796A CN202010263511.8A CN202010263511A CN111533796A CN 111533796 A CN111533796 A CN 111533796A CN 202010263511 A CN202010263511 A CN 202010263511A CN 111533796 A CN111533796 A CN 111533796A
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peptide
cells
cancer
peptides
cell
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Chinese (zh)
Inventor
M·迪·马尔科
S·海顿
D·科瓦勒斯基
M·夫勒
A·内尔德
H·拉姆森
S·斯蒂凡诺维奇
N·特劳特魏因
J·S·沃茨
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Immatics Biotechnologies GmbH
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Immatics Biotechnologies GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

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CN202010263511.8A 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物 Pending CN111533796A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762483702P 2017-04-10 2017-04-10
DE102017107697 2017-04-10
DE102017107697.2 2017-04-10
US62/483,702 2017-04-10
CN201880023922.0A CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

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CN201880023922.0A Division CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

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CN111533796A true CN111533796A (zh) 2020-08-14

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Family Applications (12)

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CN202010263602.1A Pending CN111533798A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263514.1A Pending CN111647062A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263511.8A Pending CN111533796A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263513.7A Pending CN111499714A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263515.6A Pending CN111533797A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263573.9A Pending CN111548405A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263512.2A Pending CN111528539A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263571.XA Pending CN111499715A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263601.7A Pending CN111548406A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN201880023922.0A Pending CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263575.8A Pending CN111499716A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263572.4A Pending CN111548404A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

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CN202010263602.1A Pending CN111533798A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263514.1A Pending CN111647062A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

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CN202010263513.7A Pending CN111499714A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263515.6A Pending CN111533797A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263573.9A Pending CN111548405A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263512.2A Pending CN111528539A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263571.XA Pending CN111499715A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263601.7A Pending CN111548406A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN201880023922.0A Pending CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263575.8A Pending CN111499716A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263572.4A Pending CN111548404A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

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US (3) US20220332760A1 (enExample)
EP (2) EP3609530A1 (enExample)
JP (3) JP2020516681A (enExample)
KR (2) KR20190137829A (enExample)
CN (12) CN111533798A (enExample)
AU (2) AU2018251839B2 (enExample)
BR (1) BR112019020959A2 (enExample)
CA (1) CA3059644A1 (enExample)
CL (1) CL2019002880A1 (enExample)
CO (1) CO2019012077A2 (enExample)
CR (3) CR20210160A (enExample)
IL (1) IL269741A (enExample)
MA (2) MA49122A (enExample)
MX (1) MX2019012225A (enExample)
PE (1) PE20191711A1 (enExample)
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Cited By (1)

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CN110785183A (zh) * 2017-07-07 2020-02-11 伊玛提克斯生物技术有限公司 用于肺癌(包括nsclc、sclc和其他癌症)免疫治疗的新型肽和肽组合物

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MA49122A (fr) * 2017-04-10 2021-03-24 Immatics Biotechnologies Gmbh Peptides et combinaisons de peptides destinés à être utilisés en immunothérapie anticancéreuse
WO2021247724A1 (en) * 2020-06-03 2021-12-09 Faeth Therapeutics, Inc. Formulations for personalized methods of treatment
CN111978375B (zh) * 2020-08-28 2022-10-04 深圳市乐土生物医药有限公司 具有细胞毒性t细胞诱导能力的蛋白质或多肽
CN112010960A (zh) * 2020-09-10 2020-12-01 热休(厦门)细胞生物科技有限公司 一种肿瘤抗原复合物体外致敏dc、t细胞获得肿瘤特异性杀伤细胞ctl及其制备方法
EP4340870A4 (en) * 2021-05-18 2024-11-20 Hung, Mien-Chie VACCINE, USE THEREOF AND CANCER VACCINE COCKTAIL
CN114410638B (zh) * 2022-01-24 2023-04-14 郑州大学 一种核酸适配体及其在食管癌检测中的应用
CN117586344B (zh) * 2022-08-12 2025-07-25 上海交通大学医学院附属瑞金医院 靶向flt3-d835突变的抗原肽及其在肿瘤免疫治疗中的应用
CN120712104A (zh) * 2022-10-14 2025-09-26 广东天科雅生物医药科技有限公司 针对神经胶质瘤的肽疫苗及其用途
CN116426532B (zh) * 2023-06-08 2023-09-12 时夕(广州)生物科技有限公司 一种靶向适配体及其应用
CN117552115B (zh) * 2024-01-12 2024-03-26 天津鲸鹏生物科技有限责任公司 用于诱导肿瘤特异性免疫响应的通用型抗原肽库及其应用
CN118480561A (zh) * 2024-05-30 2024-08-13 深圳大学总医院 一种aml1-eto融合基因产生的新抗原肽及其应用
CN119390773B (zh) * 2024-11-05 2025-08-12 绵阳市第三人民医院 一种具有双向调节肿瘤免疫微环境功能的多肽及其应用

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