CN111528539A - 用于癌症免疫治疗的肽及其肽组合物 - Google Patents

用于癌症免疫治疗的肽及其肽组合物 Download PDF

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Publication number
CN111528539A
CN111528539A CN202010263512.2A CN202010263512A CN111528539A CN 111528539 A CN111528539 A CN 111528539A CN 202010263512 A CN202010263512 A CN 202010263512A CN 111528539 A CN111528539 A CN 111528539A
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peptide
cells
peptides
cancer
cell
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Chinese (zh)
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M·迪·马尔科
S·海顿
D·科瓦勒斯基
M·夫勒
A·内尔德
H·拉姆森
S·斯蒂凡诺维奇
N·特劳特魏因
J·S·沃茨
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Immatics Biotechnologies GmbH
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Immatics Biotechnologies GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C12N2501/998—Proteins not provided for elsewhere

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  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Plant Pathology (AREA)
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CN202010263512.2A 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物 Pending CN111528539A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762483702P 2017-04-10 2017-04-10
US62/483,702 2017-04-10
DE102017107697 2017-04-10
DE102017107697.2 2017-04-10
CN201880023922.0A CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

Related Parent Applications (1)

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CN201880023922.0A Division CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

Publications (1)

Publication Number Publication Date
CN111528539A true CN111528539A (zh) 2020-08-14

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Family Applications (12)

Application Number Title Priority Date Filing Date
CN202010263512.2A Pending CN111528539A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263513.7A Pending CN111499714A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263602.1A Pending CN111533798A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263514.1A Pending CN111647062A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263571.XA Pending CN111499715A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263511.8A Pending CN111533796A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263572.4A Pending CN111548404A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263575.8A Pending CN111499716A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263515.6A Pending CN111533797A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN201880023922.0A Pending CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263601.7A Pending CN111548406A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263573.9A Pending CN111548405A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

Family Applications After (11)

Application Number Title Priority Date Filing Date
CN202010263513.7A Pending CN111499714A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263602.1A Pending CN111533798A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263514.1A Pending CN111647062A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263571.XA Pending CN111499715A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263511.8A Pending CN111533796A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263572.4A Pending CN111548404A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263575.8A Pending CN111499716A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263515.6A Pending CN111533797A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN201880023922.0A Pending CN110494157A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263601.7A Pending CN111548406A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物
CN202010263573.9A Pending CN111548405A (zh) 2017-04-10 2018-04-10 用于癌症免疫治疗的肽及其肽组合物

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US (3) US20220332760A1 (enExample)
EP (2) EP3725327A3 (enExample)
JP (3) JP2020516681A (enExample)
KR (2) KR20240162609A (enExample)
CN (12) CN111528539A (enExample)
AU (2) AU2018251839B2 (enExample)
BR (1) BR112019020959A2 (enExample)
CA (1) CA3059644A1 (enExample)
CL (1) CL2019002880A1 (enExample)
CO (1) CO2019012077A2 (enExample)
CR (3) CR20210160A (enExample)
IL (1) IL269741A (enExample)
MA (2) MA49122A (enExample)
MX (1) MX2019012225A (enExample)
PE (1) PE20191711A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024031811A1 (zh) * 2022-08-12 2024-02-15 上海交通大学医学院附属瑞金医院 靶向flt3-d835突变的抗原肽及其在肿瘤免疫治疗中的应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20210160A (es) * 2017-04-10 2021-04-26 Immatics Biotechnologies Gmbh Péptidos y combinaciones de los mismos para el uso en la inmunoterapia contra diversos tipos de cáncer (divisional de solicitud 2019-0508)
KR20200026898A (ko) * 2017-07-07 2020-03-11 이매틱스 바이오테크놀로지스 게엠베하 Nsclc, sclc 등 폐암 및 기타 암에 대한 면역요법에서의 사용을 위한 신규 펩티드 및 펩티드의 조합
CN116075238B (zh) * 2020-06-03 2025-11-04 菲思治疗公司 用于个体化治疗方法的制剂
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