CN111528224A - Pesticide composition containing tolfenpyrad and diafenthiuron and application thereof - Google Patents
Pesticide composition containing tolfenpyrad and diafenthiuron and application thereof Download PDFInfo
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- CN111528224A CN111528224A CN202010533100.6A CN202010533100A CN111528224A CN 111528224 A CN111528224 A CN 111528224A CN 202010533100 A CN202010533100 A CN 202010533100A CN 111528224 A CN111528224 A CN 111528224A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- Pest Control & Pesticides (AREA)
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- Plant Pathology (AREA)
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- Dispersion Chemistry (AREA)
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Abstract
The invention relates to the technical field of pesticides, and particularly relates to a pesticide composition containing tolfenpyrad and diafenthiuron and application thereof, wherein the tolfenpyrad and the diafenthiuron are in a weight portion ratio of 1: (0.2-5). Also provides a suspending agent containing tolfenpyrad and diafenthiuron, which comprises 5-15 parts of tolfenpyrad, 10-25 parts of diafenthiuron, 2-6 parts of dispersant, 0.05-2 parts of tackifier, 0.01-0.5 part of preservative, 2-7 parts of antifreeze agent, 0.1-1 part of defoaming agent and 50-70 parts of water by weight.
Description
Technical Field
The invention relates to the technical field of pesticides, and particularly relates to a pesticide composition containing tolfenpyrad and diafenthiuron and application thereof.
Background
Tolfenpyrad is a novel pyrazole heterocyclic insecticidal and acaricidal agent, and has the main action mechanism of preventing oxidative phosphorylation of insects, and also has the effects of killing eggs, inhibiting food, inhibiting egg laying and sterilizing. The pesticide has wide insecticidal spectrum, has high control effect on various bony-lepidoptera, hemiptera, beetle, hymenoptera, diptera pests and mites, also has good quick-acting property, and the pests die immediately after being treated. Is widely used for pest control of crops such as vegetables, fruit trees, flowers, tea leaves and the like.
Diafenthiuron is a novel thiourea insecticide and acaricide with the functions of contact poisoning, stomach toxicity, systemic absorption and fumigation, has a certain ovicidal effect, is converted into a substance with insecticidal activity under ultraviolet light, and has strong activity on pests with serious drug resistance on vegetables. Can be used for preventing and treating aphid, whitefly, leafhopper, noctuidae pests and mites on various crops and ornamental plants.
However, in the actual process of agricultural production, the most easily caused problem of controlling pests is the generation of resistance to pests. The compounding of different kinds of components is a common method for preventing and controlling resistant pests. Different components are compounded, and whether a certain compound has synergism, addition or antagonism is judged according to the actual application effect. In most cases, the compounding effect of the pesticide is additive effect, the compounding with real synergistic effect is little, at present, the composition used by compounding tolfenpyrad and diafenthiuron is available, but the mixing proportion of a plurality of compositions is not scientific, and the compositions can not achieve the synergistic effect but can play an antagonistic effect at random, so that the pesticide is wasted. In addition, many compositions have problems such as inability to be stored for a long period of time and low suspension rates.
Disclosure of Invention
In order to solve the technical problem, the first aspect of the invention provides a pesticide composition containing tolfenpyrad and diafenthiuron, wherein the parts by weight of tolfenpyrad and diafenthiuron are 1: (0.2-5).
As a preferable technical scheme, the preparation formulation is selected from one of suspending agent, missible oil, wettable powder, aqueous solution, tablets and granules.
The invention provides a suspending agent containing tolfenpyrad and diafenthiuron, which is prepared from the raw materials of the pesticide composition containing tolfenpyrad and diafenthiuron; the insecticide comprises, by weight, 5-15 parts of tolfenpyrad, 10-25 parts of diafenthiuron, 2-6 parts of a dispersant, 0.05-2 parts of a tackifier, 0.01-0.5 part of a preservative, 2-7 parts of an antifreeze agent, 0.1-1 part of a defoaming agent and 50-70 parts of water.
As a preferable technical scheme of the invention, the dispersant is polyether carboxylate and/or polyether phosphate.
In a preferred embodiment of the present invention, the polyether carboxylate contains a fatty alcohol structure.
In a preferred embodiment of the present invention, the polyether phosphate contains at least two benzene rings.
As a preferred technical solution of the present invention, the tackifier is selected from one or more of magnesium aluminum silicate, soluble starch, xanthan gum, organic bentonite, and sodium carboxymethylcellulose.
As a preferable technical scheme of the invention, the particle size of the magnesium aluminum silicate is 900-1200 meshes.
In a third aspect, the invention provides a preparation method of a suspending agent containing tolfenpyrad and diafenthiuron, which comprises the following steps: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
The fourth aspect of the invention provides application of a pesticide composition containing tolfenpyrad and diafenthiuron to prevention and control of prodenia litura, tea lesser leafhopper, red tangerine spider, scale insect, frankliniella occidentalis, trialeurodes vaporariorum, tea yellow thrips and tea geometrid.
Has the advantages that: the invention provides a pesticide composition containing tolfenpyrad and diafenthiuron and application thereof, and also provides a suspending agent containing tolfenpyrad and diafenthiuron.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problem, the first aspect of the invention provides a pesticide composition containing tolfenpyrad and diafenthiuron, wherein the parts by weight of tolfenpyrad and diafenthiuron are 1: (0.2-5).
In a more preferred embodiment, the weight ratio of tolfenpyrad to diafenthiuron according to the invention is 1: (1-3).
In a most preferred embodiment, the weight ratio of tolfenpyrad to diafenthiuron according to the invention is 1: 2.
tolfenpyrad
The pure tolfenpyrad product of the present invention is white solid powder, and has density (25 deg.c) of 1.18g/cm, smelting point of 87.8-88.2 deg.c, and steam pressure (25 deg.c) of 5 × 10-4And (4) mPa. Solubility (25 ℃): 0.087mg/L of water, 7.41g/L of n-hexane, 366g/L of toluene, 59.6g/L of methanol, 368g/L of acetone and 339g/L of ethyl acetate. Stability: the mixture was stabilized in water for 5d (pH4-9, 50 ℃).
Diafenthiuron
The pure product of the diafenthiuron is white crystal, and the solubility (g/l,20 ℃) of the diafenthiuron is acetone 280 cyclohexanone 380, dichloromethane 600, hexane 8, toluene 320, xylene 210, methanol 40, n-octanol 23 and water 5x10-5Is stable to light and is decomposed in isopropanol; is a novel thiourea high-efficiency insecticide and acaricide, has the functions of contact poisoning, stomach poisoning, systemic absorption and fumigation, and has a certain ovicidal effect. Low toxicity, but high toxicity to fish and bee.
The inventor of the application finds that the tolfenpyrad and the diafenthiuron are compounded for use in the research process, and compared with the single use of one of the tolfenpyrad and the diafenthiuron, the insecticidal effect and the control effect of insects are improved, especially when the weight ratio of the tolfenpyrad to the diafenthiuron is 1: (0.2-5), and when being applied to tea lesser leafhoppers, the co-toxicity coefficient is more than 120, and the synergistic effect of different degrees is shown, and the possible reason is that the diafenthiuron adopted by the invention is a precursor of the insecticide, and can be decomposed into imine compounds under the condition of ultraviolet irradiation or the existence of multifunctional oxidase, so that mitochondria in nerve cells in the bodies of pests are prevented from playing a role, and the energy conversion of the pests is influenced; the tolfenpyrad is a mitochondrial electron transfer complex inhibitor, and can prevent oxidative phosphorylation of pests and influence synthesis of a mitochondrial electron transfer system complex; the tolfenpyrad and the diafenthiuron are compounded for use, so that the synergistic effect is achieved, the oxidation capacity of organic matters in pest cells can be weakened, the possibility of combination of adenosine diphosphate and phosphoric acid is reduced, and pest catalepsy is caused, but the tolfenpyrad and the diafenthiuron have poor solubility in a water system, are easy to aggregate and precipitate, have poor dispersibility and low stability, and severely limit the application of the pesticide composition containing the tolfenpyrad and the diafenthiuron.
The formulation of the pesticide composition containing tolfenpyrad and diafenthiuron in the present invention is not particularly limited, and various formulations known to those skilled in the art can be prepared by methods known to those skilled in the art.
In a preferred embodiment, the dosage form is selected from one of suspending agents, emulsifiable concentrates, wettable powders, dusts, aqueous solutions, tablets and granules.
The invention provides a suspending agent containing tolfenpyrad and diafenthiuron, which is prepared from the raw materials of the pesticide composition containing tolfenpyrad and diafenthiuron; the insecticide comprises, by weight, 5-15 parts of tolfenpyrad, 10-25 parts of diafenthiuron, 2-6 parts of a dispersant, 0.05-2 parts of a tackifier, 0.01-0.5 part of a preservative, 2-7 parts of an antifreeze agent, 0.1-1 part of a defoaming agent and 50-70 parts of water.
In a preferred embodiment, the suspending agent containing tolfenpyrad and diafenthiuron prepared by the invention comprises the pesticide composition containing tolfenpyrad and diafenthiuron; the insecticide comprises, by weight, 8-12 parts of tolfenpyrad, 15-23 parts of diafenthiuron, 3-5.5 parts of a dispersant, 0.1-1.8 parts of a tackifier, 0.1-0.4 part of a preservative, 3-6 parts of an antifreeze agent, 0.3-0.7 part of a defoaming agent and 55-65 parts of water.
In a most preferred embodiment, the suspending agent containing tolfenpyrad and diafenthiuron prepared by the invention comprises the pesticide composition containing tolfenpyrad and diafenthiuron; the insecticide composition comprises, by weight, 10 parts of tolfenpyrad, 20 parts of diafenthiuron, 5 parts of a dispersing agent, 1.12 parts of a tackifier, 0.3 part of a preservative, 4 parts of an antifreeze agent, 0.5 part of a defoaming agent and 60 parts of water.
Dispersing agent
The dispersant of the invention is a surfactant which has two opposite properties of lipophilicity and hydrophilicity in a molecule. The amphiphilic agent is capable of uniformly dispersing inorganic/organic solid or liquid substances which are difficult to dissolve in a liquid, and also preventing the sedimentation and agglomeration of particles to form a stable suspension.
In a preferred embodiment, the dispersant of the present invention is a polyether carboxylate and/or a polyether phosphate.
In a more preferred embodiment, the polyether carboxylate of the present invention contains a fatty alcohol structure.
In a more preferred embodiment, the polyether phosphate of the present invention contains at least two benzene rings.
In a more preferred embodiment, the dispersant of the present invention is a combination of polyether carboxylate and polyether phosphate, wherein the mass ratio of polyether carboxylate and polyether phosphate is 1: (0.8-2.3).
In a more preferred embodiment, the dispersant of the present invention is a combination of sodium lauryl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium lauryl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: (0.8-2.3).
In a more preferred embodiment, the dispersant of the present invention is a combination of sodium lauryl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium lauryl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: (1-2).
In a most preferred embodiment, the dispersant of the present invention is a combination of sodium lauryl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium lauryl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: 1.5.
the inventor finds in experiments that the dispersibility of tolfenpyrad and diafenthiuron in a water system can be effectively improved by adding a dispersing agent, and particularly, the dispersing effect is better when polyether carboxylate containing a fatty alcohol structure and polyether phosphate containing a benzene ring group are adopted, and the possible reason is that the polyether carboxylate contains a long carbon chain with stronger lipophilicity, so that tolfenpyrad and diafenthiuron are easily adsorbed, the surface performance of the medicine powder is reduced, the dispersibility of the pesticide composition in the water body is improved, the polyether phosphate contains a plurality of benzene rings, the steric hindrance is larger, the electrostatic repulsion and solvation chain acting force between the polyether carboxylates are favorably improved, the agglomeration phenomenon caused by friction in the dispersing process of adjacent powder particles is effectively avoided, and the dispersibility of the medicine powder in the water system is further improved; multiple experiments prove that when the mass ratio of the polyether carboxylate to the polyether phosphate is 1: (0.8-2.3), the synergistic effect is optimal; in addition, the invention unexpectedly discovers that the use efficacy of the pesticide composition can be improved by adopting the dispersant, and the polyether carboxylate and the polyether phosphate ester contain hydrophilic and oleophilic structures through analysis, so that the surface tension of surface ester of pests can be reduced, the contact area of the drug powder and the pests is increased, the drug reaches a target part, the detoxification time of the drug in the pests is shortened, and the drug property is improved; but the suspension rate is poor after long-time standing.
Tackifier
The tackifier of the present invention is a substance that wets the surface to be bonded by surface diffusion or internal diffusion to improve the bonding strength between a material and an adherend.
In a preferred embodiment, the viscosity increasing agent of the present invention is selected from one or more of magnesium aluminum silicate, soluble starch, xanthan gum, organic bentonite, and sodium carboxymethylcellulose.
In a more preferred embodiment, the viscosity increasing agent of the present invention is a combination of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of magnesium aluminum silicate to xanthan gum is 1: (0.1-0.3).
In a more preferred embodiment, the viscosity increasing agent of the present invention is a combination of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of magnesium aluminum silicate to xanthan gum is 1: 0.12.
in a preferred embodiment, the particle size of the magnesium aluminum silicate of the present invention is 900-1200 mesh.
In a more preferred embodiment, the magnesium aluminum silicate of the present invention has a particle size of 1000 mesh and is commercially available from a manufacturer including, but not limited to, Zhengzhou Xuxin chemical Limited.
The invention is to improve the long-term storage stability of suspending agent containing tolfenpyrad and diafenthiuron, the technical means of adding tackifier is adopted, xanthan gum is commonly used as tackifier to increase the suspension rate in the prior art, but the stability of the pesticide composition after long-term storage in a water system cannot be solved, but the invention is regulated and controlled by experiments, and the invention has the advantages that the viscosity and the long-term stability of the system are greatly different by changing the particle size of the magnesium aluminum silicate and the compounding ratio of the magnesium aluminum silicate and the xanthan gum, and the possible reason is that the magnesium aluminum silicate and the xanthan gum are selected, so that the invention not only can exert the synergistic effect, but also has excellent compatibility with polyether carboxylate and polyether phosphate, and is beneficial to regulating the viscosity and the yield value of the system; secondly, the magnesium aluminum silicate with special particle size has a unique three-dimensional chain structure, so that drug particles are easy to adsorb, the tail end of the side chain of the xanthan gum molecule contains an pyruvic acid group and a hydroxyl group, so that the hydrophilic performance is improved, the sol molecule can form a gel-like net structure to support the form of solid particles, when the particle size of the magnesium aluminum silicate is 900-1200 meshes, and the mass ratio of the magnesium aluminum silicate to the xanthan gum is 1: (0.1-0.3), on the one hand, the suspension rate of the pesticide composition can be ensured, and on the other hand, the situation that the network structure of sol molecules is too dense to reduce the fluidity of the active ingredients of the pesticide and influence the using pesticide effect can be prevented.
Preservative
The preservative is an additive capable of inhibiting microbial activity and preventing putrefaction and deterioration.
In a preferred embodiment, the preservative according to the present invention is selected from one or more of sodium benzoate, potassium sorbate, sodium lactate, calcium propionate, paraben.
In a most preferred embodiment, the preservative of the present invention is sodium benzoate.
The sodium benzoate is white particles or crystal powder, has no odor or slight benzoin smell, has slightly sweet taste and astringent taste. Also known as sodium benzoate, relative molecular mass 144.12. Is stable in air, is easily soluble in water, has pH of 8, and is soluble in ethanol.
The benzoic acid preservative acts by undissociated molecules, undissociated benzoic acid has strong lipophilicity and can easily pass through a cell membrane to enter cells, interfere the permeability of microbial cell membranes such as molds and bacteria and the like, prevent the absorption of amino acid by the cell membranes, enter the benzoic acid molecules in the cells, acidify the alkali storage in the cells, and inhibit the activity of a respiratory enzyme system in the microbial cells, thereby playing a role in corrosion prevention.
The benzoic acid is a broad-spectrum antimicrobial agent, has good effect on yeast, mould and partial bacteria, and has inhibitory effect on various bacteria within the allowable maximum use range and at the pH value of below 4.5.
Antifreeze agent
The antifreeze agent is also called as a freezing inhibitor and is a substance which is added into other liquid to reduce the freezing point and improve the freezing resistance. It also has the effects of dissolving ice crystal and preventing ice crystal growth.
In a preferred embodiment, the antifreeze agent of the present invention is a small molecule alcohol.
In a most preferred embodiment, the antifreeze agent of the present invention is propylene glycol.
Defoaming agent
The antifoaming agent according to the present invention means a substance capable of reducing the surface tension of water, solution, suspension, etc., preventing the formation of foam, or reducing or eliminating the original foam.
In a preferred embodiment, the defoaming agent of the present invention is selected from one or more of ethanol, silicone defoaming agent, polyoxyethylene polyoxypropylene amine ether, and tributyl phosphate.
In a most preferred embodiment, the defoamer of the present invention is a silicone defoamer.
In a preferred embodiment, the viscosity of the silicone antifoam agent of the invention is from 45 to 65 mPas at 25 ℃.
The defoamer of the present invention is commercially available from a manufacturer including, but not limited to, the Haian petrochemical plant of Jiangsu province under the trademark "Queshan 470".
The organic silicon defoaming agent has the function of reducing the foam generation of the suspending agent in the using process, and particularly, the organic silicon defoaming agent with specific viscosity is selected to have stronger compatibility with the dispersing agent and the tackifier, so that the viscosity of a water system is prevented from being increased or reduced by adding the defoaming agent, and the stability and the prevention effect of the suspending agent are improved.
In a third aspect, the invention provides a process for the preparation of a suspension concentrate comprising tolfenpyrad and diafenthiuron, the process comprising the steps of: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
The fourth aspect of the invention provides application of a pesticide composition containing tolfenpyrad and diafenthiuron to prevention and control of prodenia litura, tea lesser leafhopper, red tangerine spider, scale insect, frankliniella occidentalis, trialeurodes vaporariorum, tea yellow thrips and tea geometrid.
It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the raw materials are commercially available and the extraction methods of the extract are all conventional extraction methods, if not otherwise specified.
Example 1
The pesticide composition containing tolfenpyrad and diafenthiuron is provided, wherein the weight part ratio of tolfenpyrad to diafenthiuron is 5: 25.
example 2
The pesticide composition containing tolfenpyrad and diafenthiuron is provided, wherein the weight part ratio of tolfenpyrad to diafenthiuron is 10: 20.
example 3
The pesticide composition containing tolfenpyrad and diafenthiuron is provided, wherein the weight part ratio of tolfenpyrad to diafenthiuron is 15: 15.
example 4
The pesticide composition containing tolfenpyrad and diafenthiuron is provided, and the weight part ratio of tolfenpyrad to diafenthiuron is 20: 10.
example 5
The pesticide composition containing tolfenpyrad and diafenthiuron is provided, wherein the weight part ratio of tolfenpyrad to diafenthiuron is 25: 5.
example 6
The pesticide composition containing tolfenpyrad and diafenthiuron is provided, and the weight part ratio of tolfenpyrad to diafenthiuron is 1: 0.
example 7
The pesticide composition containing tolfenpyrad and diafenthiuron is provided, wherein the weight part ratio of tolfenpyrad to diafenthiuron is 0: 1.
example 8
The suspending agent containing the tolfenpyrad and the diafenthiuron is provided, and the preparation raw materials of the suspending agent comprise the pesticide composition containing the tolfenpyrad and the diafenthiuron; the insecticide composition comprises, by weight, 10 parts of tolfenpyrad, 20 parts of diafenthiuron, 5 parts of a dispersing agent, 1.12 parts of a tackifier, 0.3 part of a preservative, 4 parts of an antifreeze agent, 0.5 part of a defoaming agent and 60 parts of water.
The dispersing agent is a combination of sodium dodecyl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium dodecyl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: 1.5.
the tackifier is a compound of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.12.
the particle size of the magnesium aluminum silicate is 1000 meshes, and the magnesium aluminum silicate can be obtained commercially and is manufactured by Zhengzhou Xuxin chemical industry Co.
The preservative is sodium benzoate.
The antifreeze agent is propylene glycol.
The defoaming agent can be obtained commercially, and the manufacturer is a Heian petrochemical plant in Jiangsu province and the brand is defoaming king 470.
The preparation method of the suspending agent containing tolfenpyrad and diafenthiuron comprises the following steps: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
Example 9
The suspending agent containing the tolfenpyrad and the diafenthiuron is provided, and the preparation raw materials of the suspending agent comprise the pesticide composition containing the tolfenpyrad and the diafenthiuron; the insecticide composition comprises, by weight, 5 parts of tolfenpyrad, 10 parts of diafenthiuron, 2 parts of a dispersing agent, 0.05 part of a tackifier, 0.01 part of a preservative, 2 parts of an antifreeze agent, 0.1 part of a defoaming agent and 50 parts of water.
The dispersing agent is a combination of sodium dodecyl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium dodecyl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: 1.5.
the tackifier is a compound of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.12.
the particle size of the magnesium aluminum silicate is 1000 meshes, and the magnesium aluminum silicate can be obtained commercially and is manufactured by Zhengzhou Xuxin chemical industry Co.
The preservative is sodium benzoate.
The antifreeze agent is propylene glycol.
The defoaming agent can be obtained commercially, and the manufacturer is a Heian petrochemical plant in Jiangsu province and the brand is defoaming king 470.
The preparation method of the suspending agent containing tolfenpyrad and diafenthiuron comprises the following steps: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
Example 10
The suspending agent containing the tolfenpyrad and the diafenthiuron is provided, and the preparation raw materials of the suspending agent comprise the pesticide composition containing the tolfenpyrad and the diafenthiuron; the insecticide composition comprises, by weight, 15 parts of tolfenpyrad, 25 parts of diafenthiuron, 6 parts of a dispersing agent, 2 parts of a tackifier, 0.5 part of a preservative, 7 parts of an antifreeze agent, 1 part of a defoaming agent and 70 parts of water.
The dispersing agent is a combination of sodium dodecyl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium dodecyl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: 1.5.
the tackifier is a compound of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.12.
the particle size of the magnesium aluminum silicate is 1000 meshes, and the magnesium aluminum silicate can be obtained commercially and is manufactured by Zhengzhou Xuxin chemical industry Co.
The preservative is sodium benzoate.
The antifreeze agent is propylene glycol.
The defoaming agent can be obtained commercially, and the manufacturer is a Heian petrochemical plant in Jiangsu province and the brand is defoaming king 470.
The preparation method of the suspending agent containing tolfenpyrad and diafenthiuron comprises the following steps: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
Example 11
The suspending agent containing the tolfenpyrad and the diafenthiuron is provided, and the preparation raw materials of the suspending agent comprise the pesticide composition containing the tolfenpyrad and the diafenthiuron; the insecticide composition comprises, by weight, 10 parts of tolfenpyrad, 20 parts of diafenthiuron, 5 parts of a dispersing agent, 1.12 parts of a tackifier, 0.3 part of a preservative, 4 parts of an antifreeze agent, 0.5 part of a defoaming agent and 60 parts of water.
The dispersant is sodium dodecyl alcohol polyoxyethylene ether carboxylate.
The tackifier is a compound of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.12.
the particle size of the magnesium aluminum silicate is 1000 meshes, and the magnesium aluminum silicate can be obtained commercially and is manufactured by Zhengzhou Xuxin chemical industry Co.
The preservative is sodium benzoate.
The antifreeze agent is propylene glycol.
The defoaming agent can be obtained commercially, and the manufacturer is a Heian petrochemical plant in Jiangsu province and the brand is defoaming king 470.
The preparation method of the suspending agent containing tolfenpyrad and diafenthiuron comprises the following steps: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
Example 12
The suspending agent containing the tolfenpyrad and the diafenthiuron is provided, and the preparation raw materials of the suspending agent comprise the pesticide composition containing the tolfenpyrad and the diafenthiuron; the insecticide composition comprises, by weight, 10 parts of tolfenpyrad, 20 parts of diafenthiuron, 5 parts of a dispersing agent, 1.12 parts of a tackifier, 0.3 part of a preservative, 4 parts of an antifreeze agent, 0.5 part of a defoaming agent and 60 parts of water.
The dispersant is tristyrylphenol polyoxyethylene ether phosphate.
The tackifier is a compound of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of the magnesium aluminum silicate to the xanthan gum is 1: 0.12.
the particle size of the magnesium aluminum silicate is 1000 meshes, and the magnesium aluminum silicate can be obtained commercially and is manufactured by Zhengzhou Xuxin chemical industry Co.
The preservative is sodium benzoate.
The antifreeze agent is propylene glycol.
The defoaming agent can be obtained commercially, and the manufacturer is a Heian petrochemical plant in Jiangsu province and the brand is defoaming king 470.
The preparation method of the suspending agent containing tolfenpyrad and diafenthiuron comprises the following steps: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
Example 13
Similar to example 8, except that the adhesion promoter was magnesium aluminum silicate.
Example 14
Similar to example 8, except that the viscosity increasing agent was xanthan gum.
Example 15
Similar to example 8, except that the defoamer was commercially available from Heian petrochemical plant, Jiangsu province under the designation defoamer T-504 having a viscosity of 300-.
Example 16
Similar to example 8, except that the viscosity increasing agent is a combination of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of magnesium aluminum silicate to xanthan gum is 1: 0.05.
example 17
Similar to example 8, except that the viscosity increasing agent is a combination of magnesium aluminum silicate and xanthan gum, wherein the mass ratio of magnesium aluminum silicate to xanthan gum is 1: 0.5.
example 18
Similar to example 8, except that the dispersant is a combination of sodium lauryl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium lauryl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: 0.4.
example 19
Similar to example 8, except that the dispersant is a combination of sodium lauryl alcohol polyoxyethylene ether carboxylate and tristyrylphenol polyoxyethylene ether phosphate, wherein the mass ratio of the sodium lauryl alcohol polyoxyethylene ether carboxylate to the tristyrylphenol polyoxyethylene ether phosphate is 1: 3.
example 20
Similar to example 8, except that the particle size of the magnesium aluminum silicate was 325 mesh, the manufacturer was Shijiazhuangliang mineral processing Co.
Evaluation of Performance
1. And (3) testing toxicity: the pesticidal compositions of examples 1 to 7 were each dissolved and diluted with 0.1% tween 80 water to prepare solutions having an equal mass concentration, and each solution was placed in a 250ml beaker. Placing nymph in refrigerator (0-4 deg.C) for 5-10min, taking out when it is inactive, gently soaking the nymph-carrying insect-soaking cage in the medicinal liquid for 10 s, taking out, removing the residual medicinal liquid with absorbent paper, marking respectively, placing into a biological incubator with temperature of 25 + -2 deg.C and relative humidity of 60 + -5%, and feeding five-year-old nymph with fresh and clean tea tree leaves. The nymph is treated for 30 heads at each concentration, repeated for 4 times, and the result is checked 72 hours after the nymph is treated by using 0.1% Tween 80 water soaked in acetone with the corresponding content as a control, and the control death rate is higher than 20% and is an invalid test.
Test targets: a population of Empoascaflavescens is collected from a tea garden in the mountain south Judge county, Henschel, Kyowa village. Culturing in a climatic chamber, breeding a first generation by using the tea tree tender bud heads, culturing at the temperature of 26 +/-1 ℃, and illuminating: the dark is l4h:10h, the light intensity is 2000lux, and the relative humidity is 70 +/-10%. During the test, five-instar nymphs growing regularly are selected for determination.
The statistical method comprises the following steps: respectively establishing a toxicity regression equation by taking a logarithmic value of the concentration (mg/L) of the medicament as an independent variable x and a corresponding probability value of correcting the death rate as a dependent variable y, solving the co-toxicity coefficients of two single doses in different ratios, and comparing the synergy conditions of different ratios.
And (3) virulence determination results: the results of indoor toxicity measurement of five-instar nymphs of tea lesser leafhoppers by using different compounding ratios of tolfenpyrad and diafenthiuron are shown in table 1.
TABLE 1 Tolfenpyrad and diafenthiuron compounded toxicity test results on five-instar nymphs of tea lesser leafhoppers
| Examples | Regression equation of virulence | r | LC50(mg/L) | LC90(mg/L) | Co-toxicity coefficient |
| Example 6 | Y＝3.3944+1.7110x | 0.9941 | 8.6776(6.4509-11.6728) | 48.6910 | - |
| Example 7 | Y＝2.6166+1.7272x | 0.9839 | 23.9833(17.6031-32.6760) | 132.4070 | - |
| Example 1 | Y＝3.0809+1.6976x | 0.9825 | 13.5054(9.7580-18.6920) | 76.8169 | 137.24 |
| Example 2 | Y＝3.3023+1.6984x | 0.9995 | 9.9902(7.3822-13.5195) | 56.7746 | 151.18 |
| Example 3 | Y＝3.3770+1.7081x | 0.9941 | 8.9171(6.6229-12.0060) | 50.1813 | 142.92 |
| Example 4 | Y＝3.4411+1.7168x | 0.9914 | 8.0916(6.0240-10.8687) | 45.1393 | 136.22 |
| Example 5 | Y＝3.4575+1.7425x | 0.9934 | 7.6772(5.7352-10.2767) | 41.7539 | 126.48 |
The test result shows that: when the tolfenpyrad and the diafenthiuron are compounded in a ratio of 5:25, 10:20, 15:15, 20:10 and 25:5, the co-toxicity coefficients to five-instar nymphs of the tea lesser leafhoppers are respectively 137.24, 151.18, 142.92, 136.22 and 126.48 which are all more than 120, and the synergistic effect of different degrees is shown, so that the tolfenpyrad and the diafenthiuron are compounded in a ratio of 10:20 to prevent and control the tea lesser leafhoppers better.
2. Storage stability test
After the suspension concentrates prepared in examples 8 to 20 were left at 15 ℃ for 2 weeks, the presence of flocculation, delamination and sedimentation was observed and the rating test: a, no layering exists; b, a small amount of layering exists; c, a large number of layers are formed; d, a small amount of precipitate is generated; e had a large amount of precipitates, and the test results are shown in Table 2 below.
3. Suspension rate test
The suspending agents prepared in the examples 8-20 are tested according to the GB/T14825-2006 pesticide suspension rate measurement method standard, the test to be tested is prepared into suspension with proper concentration by using standard hard water, the suspension is kept still in a measuring cylinder for a certain time under specified conditions, the mass of the effective components in the suspension and the sediment at the bottom is measured, the suspension rate is calculated, and the test results are shown in the following table 2.
TABLE 2 test results
| Storage stability | Suspension rate/% | |
| Example 8 | A | 99.2 |
| Example 9 | A | 98.8 |
| Example 10 | A | 97.9 |
| Example 11 | C | 77.6 |
| Example 12 | C | 79.2 |
| Example 13 | E | 63.4 |
| Example 14 | E | 68.1 |
| Example 15 | C | 80.2 |
| Example 16 | D | 71.5 |
| Example 17 | D | 73.6 |
| Example 18 | B | 82.3 |
| Example 19 | B | 83.5 |
| Example 20 | C | 74.9 |
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The pesticide composition containing tolfenpyrad and diafenthiuron is characterized in that the weight ratio of tolfenpyrad to diafenthiuron is 1: (0.2-5).
2. The pesticide composition containing tolfenpyrad and diafenthiuron according to claim 1, wherein the dosage form is one selected from suspending agents, emulsifiable concentrates, wettable powders, aqueous solutions, tablets and granules.
3. A suspending agent containing tolfenpyrad and diafenthiuron, which is characterized in that the preparation raw materials comprise the pesticide composition containing tolfenpyrad and diafenthiuron according to claim 1; the insecticide comprises, by weight, 5-15 parts of tolfenpyrad, 10-25 parts of diafenthiuron, 2-6 parts of a dispersant, 0.05-2 parts of a tackifier, 0.01-0.5 part of a preservative, 2-7 parts of an antifreeze agent, 0.1-1 part of a defoaming agent and 50-70 parts of water.
4. The suspending agent containing tolfenpyrad and diafenthiuron as claimed in claim 3, wherein the dispersant is polyether carboxylate and/or polyether phosphate.
5. The suspending agent containing tolfenpyrad and diafenthiuron according to claim 4, wherein the polyether carboxylate contains a fatty alcohol structure.
6. The suspending agent containing tolfenpyrad and diafenthiuron according to claim 4, wherein the polyether phosphate contains at least two benzene rings.
7. The suspending agent containing tolfenpyrad and diafenthiuron according to claim 3, wherein the viscosity-increasing agent is selected from one or more of magnesium aluminum silicate, soluble starch, xanthan gum, organic bentonite and sodium carboxymethylcellulose.
8. The suspending agent containing tolfenpyrad and diafenthiuron as claimed in claim 7, wherein the particle size of the magnesium aluminum silicate is 900-1200 meshes.
9. The process for the preparation of a suspension concentrate containing tolfenpyrad and diafenthiuron according to any one of claims 3 to 8, characterized in that it comprises the following steps: adding the dispersing agent, the preservative, the antifreeze and the disintegrating agent into water, stirring and mixing, adding tolfenpyrad and diafenthiuron, stirring and mixing, finally adding the tackifier, the disintegrating agent and the defoaming agent, and uniformly mixing to obtain the composition.
10. The application of the pesticide composition containing the tolfenpyrad and the diafenthiuron as claimed in any one of the claims 1 to 9 is characterized by being applied to the control of prodenia litura, tea lesser leafhopper, red tangerine spider, scale insect, frankliniella occidentalis, whitefly, tea yellow thrip and tea inchworm.
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