CN111514243A

CN111514243A - Traditional Chinese medicine composition for treating type 1 diabetes

Info

Publication number: CN111514243A
Application number: CN202010464298.7A
Authority: CN
Inventors: 仲崇允
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-28
Filing date: 2020-05-28
Publication date: 2020-08-11
Also published as: CN113209226A

Abstract

The invention discloses a traditional Chinese medicine for treating type 1 diabetes, which is prepared from the following raw material medicines in parts by weight: 4.5-9 parts of selaginella tamariscina, mulberry leaves and inula flower; 6-12 parts of dendrobium; 10-20 parts of purslane; 9-18 parts of selfheal; 15-30 parts of astragalus membranaceus. It is forbidden for pregnant women.

Description

Traditional Chinese medicine composition for treating type 1 diabetes

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine for treating type 1 diabetes.

Background

Type 1 diabetes is a form of diabetes, also known as insulin dependent diabetes mellitus, and patient conditions often occur in childhood or adolescent. May be an autoimmune disease. In this case, the immune system of the body attacks the beta cells that produce insulin in vivo, eventually resulting in the failure of insulin production in vivo. Most patients do not achieve glycemic control and the better glycemic control, the greater the risk of hypoglycemia. Various acute and chronic complications are high. Patients need to inject exogenous insulin to control blood glucose in vivo.

Disclosure of Invention

The invention aims to improve the defects of the prior art and provide the traditional Chinese medicine composition for treating type 1 diabetes, which can effectively improve or even eliminate the clinical symptoms of patients and has the characteristics of obvious treatment effect, short treatment period, no toxic or side effect and the like.

The traditional Chinese medicine considers that congenital endowment deficiency is the basic reason of the occurrence of diabetes, and acquired improper diet, emotional disorder, excessive sexual intercourse or over-taking of warm-dryness medicines and the like are the important conditions of the occurrence of diabetes. The occurrence and development of diabetes are related to the dysfunction of liver in smoothing flow of qi, which is the basic pathogenesis of diabetes. It is due to liver dysfunction as the initiating factor, which can lead to yin deficiency, dryness-heat, blood stasis and other pathological changes, resulting in diabetes.

Based on the theory, the invention provides a traditional Chinese medicine for treating type 1 diabetes, which is prepared from the following raw material medicines in parts by weight: 4.5-9 parts of selaginella tamariscina, mulberry leaves and inula flower; 6-12 parts of dendrobium; 10-20 parts of purslane; 9-18 parts of selfheal; 15-30 parts of astragalus membranaceus.

In a preferred embodiment, the traditional Chinese medicine composition for treating type 1 diabetes consists of the following raw material medicines in parts by weight: 9 parts of selaginella tamariscina, mulberry leaf and inula flower; 12 parts of dendrobium; 20 parts of purslane; 18 parts of selfheal; 30 parts of astragalus.

Wherein, mulberry leaf: is bitter in taste; sweet; is cold in nature. Entering lung meridian; the liver meridian. Clearing liver heat, nourishing liver, and dispelling pathogenic wind and heat; clearing away the lung-heat; improving eyesight. Mulberry leaves contain crude proteins, some of which stimulate the secretion of insulin, are a regulatory factor of insulin secretion and release in vivo, and reduce the rate of insulin decomposition. Alkaloids and polysaccharides are the main hypoglycemic components in mulberry leaves. The hypoglycemic effect of mulberry leaves is realized through two ways: the method has the advantages that alkaloid DNJ (1-deoxynojirimycin) has an inhibitory effect on activity of disaccharide degrading enzymes, so that absorption of disaccharide by small intestine is inhibited, and high peak value of blood sugar after eating is reduced; secondly, the beta cell insulin is promoted by mulberry leaf alkaloid fagomine and mulberry leaf polysaccharide, and the insulin can promote the utilization of cells to sugar, the synthesis of hepatic glycogen and the improvement of glycometabolism, thereby finally achieving the effect of reducing blood sugar. Polyhydroxy norscopolamine separated from mulberry leaves has strong glycosidase inhibition effect; can significantly reduce blood glucose level.

Astragalus root: sweet and warm. It enters lung and spleen meridians. Tonify qi, strengthen superficies, induce diuresis, expel pus, heal wound and promote tissue regeneration. Can be used for treating diabetes due to internal heat; diabetes, etc. Promoting secretion of insulin and C peptide, and increasing secretion along with time; protecting kidney, liver and lung, and relieving pathological change of glomerular mesangium.

Herba Selaginellae: pungent and even. It enters liver and heart meridians. Promoting blood circulation and restoring menstrual flow. Has obvious improvement effect on insulin resistance; obviously reduce blood sugar and increase insulin concentration.

Purslane: a monosodium glutamate; cold in nature, entering the large intestine; the liver meridian; clearing away heat and toxic materials; cooling blood and stopping dysentery;

the noradrenaline in the purslane can promote islet glands to secrete insulin, regulate the glycometabolism process of a human body, reduce the blood sugar concentration, keep the blood sugar constant and obviously reduce the blood sugar.

Selfheal: pungent, bitter and cold. It enters liver and gallbladder meridians. Clearing liver and improving vision; clearing away fire and toxic material. Resolve swelling and dissipate nodulation. An unidentified compound extracted from Prunellae Spica has an action intensity of 100mg equivalent to 22.6u insulin.

And (3) inula flower: salty, warm and nontoxic. Enter lung, liver and stomach meridians. Dissolve phlegm, descend qi, soften hardness and move water. The inula flower polysaccharide acts on pancreas, has a protective effect on pancreas injury caused by diabetes, increases insulin, obviously reduces blood sugar and has a certain improvement effect on dyslipidemia.

Dendrobe: sweet and slightly cold. It enters stomach and kidney meridians. To nourish stomach, promote the production of body fluid, nourish yin and clear heat. Can be used for treating yin deficiency and fluid deficiency, dry mouth and polydipsia. The dendrobium can obviously reduce blood sugar and glucagon and increase the secretion of insulin and C peptide. Inhibit insulin degradation, improve insulin sensitivity index, inhibit free fatty acid secretion, and reduce tumor necrosis factor of obese diabetic patients.

The traditional Chinese medicine for effectively treating type 1 diabetes is prepared from traditional Chinese herbal medicines, and is prepared by orderly matching certain natural extracts with determined components and clear effects according to a plurality of principles of traditional Chinese medicine treatment based on syndrome differentiation and modern medicine.

The invention can run through the whole process of type 1 diabetes treatment, treats both principal and secondary aspects of diseases, is not easy to relapse, is safe and reliable, has no obvious toxic and side effects, is convenient for patients to insist on taking for a long time, has no adverse reaction for years after administration, and tracks the blood examination to be normal.

The traditional Chinese medicine composition has the advantages of easily available raw materials, simple process, low cost and high efficiency, and is beneficial to pharmaceutical enterprises for medicine production and quality control; the product has low price and is easy to be accepted by patients.

The traditional Chinese medicine composition has a remarkable effect of treating type 1 diabetes, and clinical experiment results show that the formula is used for treating diabetes, one dose of the traditional Chinese medicine composition is taken every day, 100 ml of water is decocted, the traditional Chinese medicine composition is divided into two parts, one part is taken in the morning and evening, one month is taken as a treatment course, the effect is achieved in one treatment course generally, the three treatment courses are obviously improved, and the functions of the six treatment courses are basically cured. The cure rate is 82%, the significant efficiency is 90%, and the total effective rate is 100%.

The invention also provides an oral preparation prepared from the traditional Chinese medicine composition for treating type 1 diabetes, which comprises oral liquid, tablets, capsules, pills and the like, preferably the dosage forms are tablets and capsules, and one dose is taken every day in the morning and at night.

The traditional Chinese medicine composition can be prepared into various dosage forms. For example, the decocted liquid medicine is sterilized and disinfected and then packaged to prepare oral liquid; or concentrating the decoction, oven drying, adding pharmaceutically acceptable adjuvants, and making into tablet, capsule, pill, etc.

The medically acceptable auxiliary materials comprise starch, dextrin, sodium carboxymethylcellulose, polyethylene glycol, calcium hydrophosphate, sodium alginate, potassium sorbate and the like.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.

Claims

1. The traditional Chinese medicine for treating type 1 diabetes is characterized by comprising the following raw material medicines in parts by weight: 4.5-9 parts of selaginella tamariscina, mulberry leaves and inula flower; 6-12 parts of dendrobium; 10-20 parts of purslane; 9-18 parts of selfheal; 15-30 parts of astragalus membranaceus.

2. The traditional Chinese medicine for treating type 1 diabetes as claimed in claim 1, which is characterized by comprising the following raw material medicines in parts by weight: 9 parts of selaginella tamariscina, mulberry leaf and inula flower; 12 parts of dendrobium; 20 parts of purslane; 18 parts of selfheal; 30 parts of astragalus.

3. An oral preparation for treating type 1 diabetes, which is prepared from the traditional Chinese medicine composition of any one of claims 1 or 2.

4. The oral preparation for treating type 1 diabetes mellitus as claimed in claim 3, which comprises oral liquid, tablets, capsules and pills, preferably oral liquid and tablets.