CN111514232A - 一种清热化痰、止咳的中药制剂及其制备方法、应用 - Google Patents
一种清热化痰、止咳的中药制剂及其制备方法、应用 Download PDFInfo
- Publication number
- CN111514232A CN111514232A CN202010461994.2A CN202010461994A CN111514232A CN 111514232 A CN111514232 A CN 111514232A CN 202010461994 A CN202010461994 A CN 202010461994A CN 111514232 A CN111514232 A CN 111514232A
- Authority
- CN
- China
- Prior art keywords
- parts
- clearing heat
- eliminating phlegm
- relieving cough
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010011224 Cough Diseases 0.000 title claims abstract description 47
- 206010062717 Increased upper airway secretion Diseases 0.000 title claims abstract description 40
- 208000026435 phlegm Diseases 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 24
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 20
- 210000004072 lung Anatomy 0.000 claims abstract description 20
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 19
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 19
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 19
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 19
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 19
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 19
- 235000011477 liquorice Nutrition 0.000 claims abstract description 19
- 206010036790 Productive cough Diseases 0.000 claims abstract description 15
- 241000931705 Cicada Species 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 208000003251 Pruritus Diseases 0.000 claims abstract description 6
- 210000003800 pharynx Anatomy 0.000 claims abstract description 6
- 208000024794 sputum Diseases 0.000 claims abstract description 6
- 210000003802 sputum Anatomy 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 238000001914 filtration Methods 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 240000000691 Houttuynia cordata Species 0.000 claims description 18
- 235000013719 Houttuynia cordata Nutrition 0.000 claims description 18
- 241000245665 Taraxacum Species 0.000 claims description 18
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 17
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 17
- 244000144725 Amygdalus communis Species 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 16
- 240000006023 Trichosanthes kirilowii Species 0.000 claims description 15
- 235000009818 Trichosanthes kirilowii Nutrition 0.000 claims description 15
- 240000006688 Telosma cordata Species 0.000 claims description 14
- 235000017352 Telosma cordata Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 11
- 235000003893 Prunus dulcis var amara Nutrition 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 10
- 239000012153 distilled water Substances 0.000 claims description 8
- 238000004806 packaging method and process Methods 0.000 claims description 8
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 6
- 235000020224 almond Nutrition 0.000 claims description 6
- 238000002372 labelling Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 244000276331 Citrus maxima Species 0.000 claims description 4
- 235000001759 Citrus maxima Nutrition 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 3
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims description 2
- 244000078912 Trichosanthes cucumerina Species 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 13
- 244000018633 Prunus armeniaca Species 0.000 abstract description 3
- 235000009827 Prunus armeniaca Nutrition 0.000 abstract description 3
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 15
- 208000006673 asthma Diseases 0.000 description 11
- 239000013641 positive control Substances 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 230000000954 anitussive effect Effects 0.000 description 3
- 230000029142 excretion Effects 0.000 description 3
- 201000003453 lung abscess Diseases 0.000 description 3
- 229940069338 potassium sorbate Drugs 0.000 description 3
- 235000010241 potassium sorbate Nutrition 0.000 description 3
- 239000004302 potassium sorbate Substances 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000675108 Citrus tangerina Species 0.000 description 2
- 241000218176 Corydalis Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 241000612118 Samolus valerandi Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 208000013116 chronic cough Diseases 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010051602 Laziness Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 210000003489 abdominal muscle Anatomy 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000000210 effect on cough Effects 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Animal Husbandry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于中药技术领域，具体公开一种清热化痰、止咳的中药制剂，由以下原料制成：苦杏仁、川贝母、地龙、桔梗、鱼腥草、黄芩、蒲公英、紫花地丁、前胡、蝉蜕、化橘红、桑白皮、瓜蒌、甘草。本发明还提供一种清热化痰、止咳的中药制剂的制备方法和应用。本发明提供的清热化痰、止咳的中药制剂，安全、有效，对风热犯肺所致的咳嗽、咽痒、咽痛、咯痰色黄或痰粘难咯具有很好的治疗效果。
Description
技术领域
本发明属于中药技术领域，具体公开一种清热化痰、止咳的中药制剂及其制备方法、应用。
背景技术
感冒多痰是极其常见的疾病，给患者带来诸多不适。痰多有很多原因，多数是因为：外感失治，或体弱屡患外感，肺气被伤，不能输津四布，通调水道下输膀胱，使水液停留，也可成痰，痰贮于肺，肺气不利，痰涌气道而发，必致咳嗽痰多。长期咳嗽、痰多容易演变成为习惯性病症，治疗不及时，容易引起哮喘和气管炎症。现有的西药治疗对人体的副作用较大，也易产生依懒性。
发明内容
本发明提供一种清热化痰、止咳的中药制剂，安全、有效，对风热犯肺所致的咳嗽、咽痒、咽痛、咯痰色黄或痰粘难咯具有很好的治疗效果。
本发明提供的清热化痰、止咳的中药制剂，由以下重量份数的原料制成：苦杏仁40-50份、川贝母40-50份、地龙40-50份、桔梗30-50份、鱼腥草100-120份、黄芩30-50份、蒲公英100-120份、紫花地丁75-90份、前胡40-50份、蝉蜕100-120份、化橘红40-50份、桑白皮50-65份、瓜蒌100-120份、甘草30-50份。
优选地，由以下重量份数的原料制成：苦杏仁48份、川贝母48份、地龙48份、桔梗40份、鱼腥草120份、黄芩40份、蒲公英120份、紫花地丁80份、前胡48份、蝉蜕120份、化橘红48份、桑白皮60份、瓜蒌120份、甘草40份。
本发明还提供一种清热化痰、止咳的中药制剂的制备方法，具体包括以下步骤：
步骤1、称取苦杏仁40-50份、川贝母40-50份、地龙40-50份、桔梗30-50份、鱼腥草100-120份、黄芩30-50份、蒲公英100-120份、紫花地丁75-90份、前胡40-50份、蝉蜕100-120份、化橘红40-50份、桑白皮50-65份、瓜蒌120g、甘草30-50份，备用；
步骤2、将步骤1中称取的杏仁、川贝母、地龙、桔梗、鱼腥草、黄芩、蒲公英、紫花地丁、前胡、蝉蜕、化橘红、桑白皮、瓜蒌、甘草混合，加水煎煮提取后浓缩，醇沉，过滤，滤液定容后，依次混匀、分装、灭菌、贴标签、质检、包装即得。
优选地，步骤2中的加水煎煮提取的具体过程为：加入相当于药材总重量8-12倍量的水，浸泡1h，煎煮2h，煎煮液过滤，收集滤液；滤渣再加入相当于其总重量6-8倍量的水，浸泡0.5h，煎煮1.5h，煎煮液过滤，收集滤液；合并两次滤液，浓缩至药液相对密度为1.12-1.15。
优选地，所述醇沉的具体过程为：加入乙醇溶液并使药液中乙醇的质量含量为60％，静置72h后，过滤，回收乙醇后，剩余溶液再加入蒸馏水至800mL，静置72h后，过滤，收集滤液。
本发明还提供一种清热化痰、止咳的中药制剂在制备治疗风热犯肺所致的咳嗽、咽痒、咽痛、咯痰色黄或痰粘难咯的药物中的应用。
风热犯肺所致的咳嗽、咽痒、咽痛、咯痰色黄或痰粘难咯在西医上属于呼吸系统急性感染性疾病，如急性支气管炎、慢性急性发作，肺脓疡等，属于中医学的咳嗽、肺痈、喘证等病的范畴，其主要病机在热痰火之邪内蕴于肺，造成肺的宣发肃降功能失常而见痰，咳喘等症。
本发明提供的清热化痰、止咳的中药制剂，方中鱼腥草清热解毒、消痈排脓，用于肺痈吐脓、痰热喘咳，蒲公英清热解毒、消肿散结，用于咽痛、肺痈，以上两味药以清肺热为君药；橘红理气、散结、止痛，蒌仁润肺化痰、滑肠通便，川贝清热润肺、化痰止咳，前胡疏风散热、降气化痰，四者联用以化痰止咳为臣药；地龙清热定惊、平喘，用于高热神昏、肺热咳喘，地丁清热解毒、凉血消肿，桑皮泄肺平喘、利水消肿，用于肺热咳喘，黄芩清热燥湿、泻火解毒，用于肺热咳嗽，以上四味药以清热为臣药；橘红、蒌仁、川贝、地龙、地丁、桑皮、黄芩、前胡共为臣药，以奏平喘、清热解毒燥湿之效；杏仁降气止咳平喘，用于咳嗽气喘，桔梗宣肺、利咽、祛痰，用于咳嗽痰多，甘草补脾益气、清热解毒、祛痰止咳，用于咳嗽痰多，蝉蜕疏散风热、利咽，四者合用以止咳宣肺为佐药。全方共奏清热化痰、宣肺止咳之功效，主治风热犯肺所致的咳嗽、咽痒、咽痛、咯痰色黄或痰粘难咯等症。
具体实施方式
为了使本领域技术人员更好地理解本发明的技术方案能予以实施，下面结合具体实施例对本发明作进一步说明，但所举实施例不作为对本发明的限定。
实施例1
一种清热化痰、止咳的中药制剂，由以下原料制成：苦杏仁40g、川贝母40g、地龙40g、桔梗30g、鱼腥草100g、黄芩30g、蒲公英100g、紫花地丁75g、前胡40g、蝉蜕100g、化橘红40g、桑白皮50g、瓜蒌120g、甘草30g。
具体制备方法包括以下步骤：
步骤1、称取苦杏仁40g、川贝母40g、地龙40g、桔梗30g、鱼腥草100g、黄芩30g、蒲公英100g、紫花地丁75g、前胡40g、蝉蜕100g、化橘红40g、桑白皮50g、瓜蒌120g、甘草30g，备用；
步骤2、将步骤1中称取的杏仁、川贝母、地龙、桔梗、鱼腥草、黄芩、蒲公英、紫花地丁、前胡、蝉蜕、化橘红、桑白皮、瓜蒌、甘草混合，加入相当于药材总重量8倍量的水，浸泡1h，煎煮2h，煎煮液过滤，收集第一次滤液；滤渣再加入相当于其总重量6倍量的水，浸泡0.5h，煎煮1.5h，煎煮液过滤，收集第二次滤液；合并两次滤液，在压力小于0.3Mpa的条件下浓缩药液体积至300mL，加入乙醇溶液并使药液中乙醇的质量含量为60％，静置72h后，过滤，在压力为0.1Mpa条件下回收乙醇后，剩余溶液再加入蒸馏水至800mL，静置72h后，过滤，收集滤液；滤液加入5％山梨醇，静置12h后滤过，滤液依次加入0.2％山梨酸钾及2％蔗糖，混匀，加蒸馏水制成1000mL，混匀、分装、灭菌、贴标签、质检、包装即得。
使用方法：每次10-15mL，一日2-3次。
实施例2
一种清热化痰、止咳的中药制剂，由以下原料制成：苦杏仁50g、川贝母50g、地龙50g、桔梗50g、鱼腥草120g、黄芩50g、蒲公英120g、紫花地丁90g、前胡50g、蝉蜕120g、化橘红50g、桑白皮65g、瓜蒌120g、甘草50g。
具体制备方法包括以下步骤：
步骤1、称取苦杏仁50g、川贝母50g、地龙50g、桔梗50g、鱼腥草120g、黄芩50g、蒲公英120g、紫花地丁90g、前胡50g、蝉蜕120g、化橘红50g、桑白皮65g、瓜蒌120g、甘草50g，备用；
步骤2、将步骤1中称取的杏仁、川贝母、地龙、桔梗、鱼腥草、黄芩、蒲公英、紫花地丁、前胡、蝉蜕、化橘红、桑白皮、瓜蒌、甘草混合，加入相当于药材总重量12倍量的水，浸泡1h，煎煮2h，煎煮液过滤，收集第一次滤液；滤渣再加入相当于其总重量8倍量的水，浸泡0.5h，煎煮1.5h，煎煮液过滤，收集第二次滤液；合并两次滤液，在压力小于0.3Mpa的条件下浓缩至药液体积为300mL，加入乙醇溶液并使药液中乙醇的质量含量为60％，静置72h后，过滤，在压力为0.1Mpa条件下回收乙醇后，剩余溶液再加入蒸馏水至800mL，静置72h后，过滤，收集滤液；滤液加入0.5％海藻酸钠，静置12h后滤过，滤液依次加入0.2％山梨酸钾及加入2％蔗糖，加蒸馏水制成1000mL，混匀、分装、灭菌、贴标签、质检、包装即得。
使用方法：每次10-15mL，一日2-3次。
实施例3
一种清热化痰、止咳的中药制剂，由以下原料制成：苦杏仁48g、川贝母48g、地龙48g、桔梗40g、鱼腥草120g、黄芩40g、蒲公英120g、紫花地丁80g、前胡48g、蝉蜕120g、化橘红48g、桑白皮60g、瓜蒌120g、甘草40g。
具体制备方法包括以下步骤：
步骤1、称取苦杏仁48g、川贝母48g、地龙48g、桔梗40g、鱼腥草120g、黄芩40g、蒲公英120g、紫花地丁80g、前胡48g、蝉蜕120g、化橘红48g、桑白皮60g、瓜蒌120g、甘草40g，备用；
步骤2、将步骤1中称取的杏仁、川贝母、地龙、桔梗、鱼腥草、黄芩、蒲公英、紫花地丁、前胡、蝉蜕、化橘红、桑白皮、瓜蒌、甘草混合，加入相当于药材总重量12倍量的水，浸泡1h，煎煮2h，煎煮液过滤，收集第一次滤液；滤渣再加入相当于其总重量8倍量的水，浸泡0.5h，煎煮1.5h，煎煮液过滤，收集第二次滤液；合并两次滤液，在压力小于0.3Mpa的条件下浓缩至药液为300mL，加入乙醇溶液并使药液中乙醇的质量含量为60％，静置72h后，过滤，在压力为0.1Mpa条件下回收乙醇后，剩余溶液再加入蒸馏水至800mL，静置72h后，过滤，收集滤液；滤液加入5％山梨醇，静置12h后滤过，滤液依次加入0.2％山梨酸钾及加入2％蔗糖，加蒸馏水制成1000mL，混匀、分装、灭菌、贴标签、质检、包装即得。
使用方法：每次10-15mL，一日2-3次。
下面对实施例1-3提供的中药制剂的效果进行评价。
1、方法
1.1、镇咳作用
昆明小数50只，随机分成实施例1组、实施例2组、实施例3组及阳性对照组、空白对照组，每组10只，雌雄各半。实施例1-3三组按照3.6g/kg的计量给药，阳性对照组使用清肺化痰颗粒(2.8g/kg)给药，空白对照组给予生理盐水，连续灌胃给药7天，末次给药1h后，将小数放入倒置的玻璃罩中，罩内悬挂2cm*5cm滤纸片，滤纸上喷氨水0.5mL，30s后将小鼠放入烧杯中，以小鼠腹肌收缩或缩胸，同时张大嘴咳嗽为指标，记录小鼠首次咳嗽时间及5min内小鼠咳嗽次数。
1.2、祛痰作用
选取昆明小数50只，随机分成实施例1组、实施例2组、实施例3组及阳性对照组、空白对照组，每组10只，雌雄各半。禁食不禁水12h后分别灌胃给药，实施例1-3三组按照3.6g/kg的计量给药，阳性对照组使用清肺化痰颗粒(2.8g/kg)，空白对照组给予生理盐水。0.5h后腹腔注射7mmoL/mL酚红溶液0.5mL，注射后0.5h脱颈椎处死小鼠，剪开颈正中皮肤，分离气管，于喉头下将磨平的针头插入气管内约0.3cm，用丝线结扎固定后，用注射器吸取2.24moL/mL碳酸氢钠溶液0.5mL，通过针头来回灌洗呼吸道3次，将灌洗液注入比色管中，重新吸取碳酸氢钠溶液0.5mL，如上再灌洗3次，再第3次同样灌洗。抽洗9次，将3次的洗液合并置于比色管中，在可见分光光度计中测定OD值。
2、结果
2、1镇咳作用
结果见表1。
表1各组对小数镇咳作用的影响
| 分组 | 咳嗽次数(次/5min) | 潜伏期(s) |
| 实施例1 | 6.87±3.26* | 21.14±1.57 |
| 实施例2 | 7.01±2.89* | 25.76±2.85 |
| 实施例3 | 6.72±3.43* | 22.87±3.04 |
| 阳性对照组 | 7.56±5.24 | 18.45±2.93 |
| 空白对照组 | 13.71±2.56 | 10.34±6.38 |
注：*表示与空白对照组相比，p<0.05。
由表1可知，实施例各组与空白对照组相比，能明显降低小鼠的咳嗽次数(p<0.05)，而对咳嗽潜伏期有增加的趋势，但无明显的差异性，与阳性对照组相比咳嗽次数均有减少，但差异不明显，说明本发明提供的制剂具有很好的镇咳作用。
2.2祛痰作用
结果见表2。
表2各组对小鼠酚红排泄量的影响
| 分组 | OD值 | 排泄量(ug/mL) |
| 实施例1 | 0.28±0.76* | 33.34±6.63* |
| 实施例2 | 3.01±0.54* | 29.41±7.02* |
| 实施例3 | 0.25±0.47* | 31.49±6.87* |
| 阳性对照组 | 0.26±0.37 | 25.44±5.47 |
| 空白对照组 | 0.19±0.75 | 20.12±6.44 |
注：*表示与空白对照组相比，p<0.05。
由表2可知，实施例各组与空白对照组相比，对小鼠呼吸道酚红的排泄量有明显的的增加作用(p<0.05)，与阳性对照组相比差异不显著，表明本申请提供的中药制剂具有明显的祛痰作用。
需要说明的是，本发明权利要求书中涉及数值范围时，应理解为每个数值范围的两个端点以及两个端点之间任何一个数值均可选用，由于采用的步骤方法与实施例1～3相同，为了防止赘述，本发明描述了优选的实施例，但本领域内的技术人员一旦得知了基本创造性概念，则可对这些实施例作出另外的变更和修改。所以，所附权利要求意欲解释为包括优选实施例以及落入本发明范围的所有变更和修改。
显然，本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样，倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内，则本发明也意图包含这些改动和变型在内。
Claims (6)
1.一种清热化痰、止咳的中药制剂，其特征在于，由以下重量份数的原料制成：苦杏仁40-50份、川贝母40-50份、地龙40-50份、桔梗30-50份、鱼腥草100-120份、黄芩30-50份、蒲公英100-120份、紫花地丁75-90份、前胡40-50份、蝉蜕100-120份、化橘红40-50份、桑白皮50-65份、瓜蒌100-120份、甘草30-50份。
2.根据权利要求1所述的清热化痰、止咳的中药制剂，其特征在于，由以下重量份数的原料制成：苦杏仁48份、川贝母48份、地龙48份、桔梗40份、鱼腥草120份、黄芩40份、蒲公英120份、紫花地丁80份、前胡48份、蝉蜕120份、化橘红48份、桑白皮60份、瓜蒌120份、甘草40份。
3.根据权利要求1所述的清热化痰、止咳的中药制剂的制备方法，其特征在于，具体包括以下步骤：
步骤1、称取苦杏仁40-50份、川贝母40-50份、地龙40-50份、桔梗30-50份、鱼腥草100-120份、黄芩30-50份、蒲公英100-120份、紫花地丁75-90份、前胡40-50份、蝉蜕100-120份、化橘红40-50份、桑白皮50-65份、瓜蒌120g、甘草30-50份，备用；
步骤2、将步骤1中称取的杏仁、川贝母、地龙、桔梗、鱼腥草、黄芩、蒲公英、紫花地丁、前胡、蝉蜕、化橘红、桑白皮、瓜蒌、甘草混合，加水煎煮提取后浓缩，醇沉，过滤，滤液定容后，依次混匀、分装、灭菌、贴标签、质检、包装即得。
4.根据权利要求3所述的清热化痰、止咳的中药制剂的制备方法，其特征在于，步骤2中的加水煎煮提取的具体过程为：加入相当于药材总重量8-12倍量的水，浸泡1h，煎煮2h，煎煮液过滤，收集滤液；滤渣再加入相当于其总重量6-8倍量的水，浸泡0.5h，煎煮1.5h，煎煮液过滤，收集滤液；合并两次滤液，浓缩至药液相对密度为1.12-1.15。
5.根据权利要求3所述的清热化痰、止咳的中药制剂的制备方法，其特征在于，所述醇沉的具体过程为：加入乙醇溶液并使药液中乙醇的质量分数为60％，静置72h后，过滤，回收乙醇后，剩余溶液再加入蒸馏水至800mL，静置72h后，过滤，收集滤液。
6.一种如权利要求1-2任一项所述的清热化痰、止咳的中药制剂在制备治疗风热犯肺所致的咳嗽、咽痒、咽痛、咯痰色黄或痰粘难咯的药物中的应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010461994.2A CN111514232A (zh) | 2020-05-27 | 2020-05-27 | 一种清热化痰、止咳的中药制剂及其制备方法、应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010461994.2A CN111514232A (zh) | 2020-05-27 | 2020-05-27 | 一种清热化痰、止咳的中药制剂及其制备方法、应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111514232A true CN111514232A (zh) | 2020-08-11 |
Family
ID=71908167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010461994.2A Pending CN111514232A (zh) | 2020-05-27 | 2020-05-27 | 一种清热化痰、止咳的中药制剂及其制备方法、应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111514232A (zh) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552509A (zh) * | 2010-12-22 | 2012-07-11 | 四川省中医药科学院中医研究所 | 清热止咳中药组合物 |
-
2020
- 2020-05-27 CN CN202010461994.2A patent/CN111514232A/zh active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552509A (zh) * | 2010-12-22 | 2012-07-11 | 四川省中医药科学院中医研究所 | 清热止咳中药组合物 |
Non-Patent Citations (1)
| Title |
|---|
| 王庆高: "风热咳嗽", 《广西中医药》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104547496A (zh) | 一种润肺止咳的中药组合物及其制备方法 | |
| CN101468089A (zh) | 一种宣肺解表止咳化痰的中药组合物及其制备方法 | |
| CN112587602B (zh) | 一种止咳化痰的中药组合物、提取物及其制备方法和应用 | |
| CN109316551A (zh) | 一种治疗急性咽炎的中药组合物及其制备方法 | |
| CN111358906B (zh) | 一种适用于外感症的中药组合物 | |
| CN102526236B (zh) | 一种治疗流行性感冒的药物及其制备方法 | |
| CN111514232A (zh) | 一种清热化痰、止咳的中药制剂及其制备方法、应用 | |
| CN102626511B (zh) | 一种用于止咳祛痰的药物组合物 | |
| CN105250771A (zh) | 一种治疗慢性咽炎的中药口服液及制备方法 | |
| CN108144037B (zh) | 一种治疗咳嗽的中药组合物及其应用 | |
| CN110613797A (zh) | 一种用于治疗咽喉肿痛的中药制剂及其制备方法 | |
| CN104491318A (zh) | 一种治疗哮喘的中药制剂及其制备方法 | |
| CN104435957A (zh) | 一种治疗肺脓肿的中药制剂的制备方法 | |
| CN108992580A (zh) | 用于化痰止咳的中药组合物及其制备方法 | |
| CN100457177C (zh) | 一种清肺、补肾的中药保健制剂 | |
| CN101934048B (zh) | 一种治疗呼吸道感染性疾病的中药复方制剂及其制备方法 | |
| CN106389589A (zh) | 一种具有止咳化痰功效的药物 | |
| CN105055702A (zh) | 一种用于治疗慢性盆腔炎的药物制剂 | |
| CN105477430A (zh) | 一种含艾叶的预防和/或治疗小儿反复感冒的中药制剂 | |
| CN104257956A (zh) | 一种止咳平喘的中药组合物 | |
| CN105055786A (zh) | 一种用于治疗咳嗽的药物制剂 | |
| CN105194165A (zh) | 一种用于泌尿系统感染的中药及制备方法 | |
| CN104398610A (zh) | 一种治疗咳嗽的药物及其制备方法 | |
| CN104873879A (zh) | 一种用于治疗失眠的药物制剂 | |
| CN104491331B (zh) | 一种具有止咳作用的药物组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200811 |
|
| RJ01 | Rejection of invention patent application after publication |