CN111491652A

CN111491652A - Traditional Chinese medicine composition for treating consumptive disease and preparation method and pharmaceutical application thereof

Info

Publication number: CN111491652A
Application number: CN201880028274.8A
Authority: CN
Inventors: 刘志杰
Original assignee: Shenzhen Dedao Health Management Co ltd
Current assignee: Shenzhen Dedao Health Management Co ltd
Priority date: 2018-11-27
Filing date: 2018-11-27
Publication date: 2020-08-04
Also published as: WO2020107217A1

Abstract

A Chinese medicinal composition for treating consumptive disease, and its preparation method and pharmaceutical application are provided. The composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15-75 parts of cassia twig, 30-240 parts of astragalus, 60-180 parts of ginger, 10-45 parts of angelica, 5-25 parts of honey-fried licorice root, 5-25 parts of ginseng and 10-45 parts of peony. The preparation method comprises soaking in water, and decocting to obtain medicinal liquid. Has the effect of treating consumptive disease caused by diseases.

Description

[ invention name prepared by ISA according to rules of detail 37.2 ] Chinese medicinal composition for treating consumptive disease, preparation method and pharmaceutical use thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a preparation method and application thereof.

Background

In daily life, internal injury and external infection are easily caused by abnormal emotion or behavior, exceeding the self-regulation range of human body or the change of external environment cold and heat, and particularly, the internal injury is: the diseases of syncope and yin fullness are characterized by intolerance of cold and cold, abnormal cold and heat, hypodynamia, insufficient energy, dysphoria with smothery sensation in chest, fullness and cold in chest and abdomen under the heart, eructation and hiccup, indigestion, stuffy and uncomfortable feeling between the two ribs, or emaciation of body, headache, unclear vision, hypomnesis, poor sleep, borborygmus, lower abdomen spasm, pain, scanty and reddish urine, dribbling or turbid urine, sexual hypofunction and the like, and the tongue condition with intermingled cold and heat, wiry pulse or hollow pulse. And exogenous diseases: apoplexy due to affection of exogenous solar energy, wind-cold-dampness, etc., with symptoms of aversion to cold, cold body, fever, sweating, aversion to wind-cold, headache, body pain, asthenia, deficiency, asthenia, marasmus, retching, chest distress, fullness and oppression in the lower heart, spasm and pain in the lower abdomen, difficulty in urination and defecation, etc. For the above-mentioned common diseases, if western medicines are taken each time for relieving or treating, a certain side effect or drug resistance is easily formed on the human body for a long time. Meanwhile, no traditional Chinese medicine compound with better curative effect exists at present.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: how to provide a traditional Chinese medicine composition to solve the symptoms in the background technology.

In order to solve the technical problems, the invention discloses a traditional Chinese medicine composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15-75 parts of cassia twig, 30-240 parts of astragalus, 60-180 parts of ginger, 10-45 parts of angelica, 5-25 parts of honey-fried licorice root, 5-25 parts of ginseng and 10-45 parts of peony.

Further, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of cassia twig, 160-220 parts of astragalus membranaceus, 80-100 parts of ginger, 10-15 parts of angelica sinensis, 10-15 parts of honey-fried licorice root, 10-15 parts of ginseng and 15-25 parts of peony.

Further, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 40-50 parts of cassia twig, 40-60 parts of astragalus, 125 parts of ginger 105-.

Further, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 55-65 parts of cassia twig, 70-140 parts of astragalus root, 160 parts of ginger 130-.

Further, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 45 parts of cassia twig, 45 parts of astragalus, 120 parts of ginger, 15 parts of angelica, 15 parts of honey-fried licorice root, 15 parts of ginseng and 30 parts of Chinese herbaceous peony.

In addition, a preparation method of the traditional Chinese medicine composition is also disclosed, and specifically, the preparation method comprises the following steps:

s1, mixing, namely weighing the traditional Chinese medicine raw materials of cassia twig, astragalus, ginger, angelica, honey-fried licorice root, ginseng and peony according to the mixture ratio;

s2, soaking, namely soaking the weighed traditional Chinese medicine raw materials in water;

s3, decocting, heating and decocting the soaked traditional Chinese medicine raw materials;

s4, filtering, and filtering after the decoction is finished to remove the dregs of a decoction to obtain the decoction.

Further, in the above preparation method, in the step of S2 soaking, water is added in an amount of 6-8 times of the total weight of the Chinese medicinal raw materials, and soaking is performed for 20-40 min.

Further, in the preparation method, in the step of S3 decoction, the decoction is firstly heated to boiling and then continuously decocted for 60-90min at the temperature of 100-115 ℃.

Further, in the above preparation method, in the S4 filtration step, the volume of the finally obtained decoction is 13/40-16/40 corresponding to the added water amount.

Finally, the scheme also discloses an application of the traditional Chinese medicine composition, and particularly relates to the application of the traditional Chinese medicine composition in preparation of medicines for regulating yin and yang, removing stagnation and tonifying deficiency.

The traditional Chinese medicine composition disclosed by the invention is prepared from cassia twig, astragalus, ginger, angelica, honey-fried licorice root, ginseng and peony which are traditional Chinese medicine raw materials, has the obvious symptoms of yin and yang harmonization, and has the symptoms of chilliness, cold and cold disorder, hypodynamia, insufficient energy, dysphoria with smothery sensation in the chest, fullness and fullness in the chest and abdomen under the heart, eructation and hiccup, indigestion in the diet, stuffiness and distension between the two ribs, or emaciation of the body, headache, blurred vision, hypomnesis, poor sleep, borborborborygmus, lower abdomen spasm, pain, scanty urine with reddish urine, dribbling or turbid urine, sexual function decline and the like, and the symptoms of tongue with mixed cold and heat, wiry pulse or hollow pulse, and fullness in chest, wind-cold and cold syndrome, wind-cold and damp inclusion and the like, eliminating stagnation and tonifying deficiency.

Drawings

[ correction 09.01.2019 according to rules 91 ] embodiments of the present invention are described in detail below with reference to the accompanying drawings

[ correcting 09.01.2019 according to rules 91 ] FIG. 1 is a flow chart of a method for preparing a Chinese medicinal composition of the present invention

Detailed Description

In order to explain the technical content, the objects and the effects of the present invention in detail, the following description will be given in conjunction with the embodiments.

Example 1

A traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 75g of cassia twig, 30g of astragalus, 180g of ginger, 10g of angelica, 5g of honey-fried licorice root, 25g of ginseng and 45g of peony. The preparation method comprises weighing 75g of cassia twig, 30g of astragalus, 180g of ginger (slice), 10g of angelica, 5g of honey-fried licorice root, 25g of ginseng (slice) and 45g of peony respectively, and adding the raw materials into a traditional Chinese medicine decocting pot together. Adding 2220ml water into the decocting tank, and soaking for 20 min. Then heating the decocting pot with strong fire until boiling in the decocting pot, adjusting to small fire, and keeping the heating temperature at 100-. Turning off the fire, filtering the solid-liquid mixture in the decocting pot, and removing the residue to obtain 888ml of decoction.

In the composition, the Chinese medicinal material cassia twig, which is pungent and warm in property, is good at dispelling wind-cold, can treat cold, wind-cold, fever and aversion to cold, and can be applied to both sweating and anhidrosis. Radix astragali has effects of invigorating qi, consolidating superficial resistance, promoting urination, expelling pus, healing sore, and promoting granulation. Can be used for treating deficiency of qi, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, exterior deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, intractable ulcer, blood deficiency, debility with yellowish complexion, internal heat, and diabetes. Fresh ginger has the effects of relieving exterior syndrome, dispelling cold, warming middle energizer, arresting vomiting, resolving phlegm and relieving cough. Can be used for treating common cold due to wind-cold, emesis due to stomach cold, and cough due to cold phlegm. Radix Angelicae sinensis has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, etc. Prepared licorice root, radix Glycyrrhizae Praeparata has the effects of invigorating spleen, regulating stomach function, benefiting qi and restoring pulse. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, and intermittent pulse. Ginseng has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing mind. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, asthenia, palpitation, insomnia, heart failure, and cardiogenic shock. Radix Paeoniae is bitter, sour and slightly cold in nature, has effects of calming liver, relieving pain, nourishing blood, regulating menstruation, astringing yin, and arresting sweating, and can be used for treating headache, giddiness, hypochondriac pain, abdominal pain, limb spasm pain, blood deficiency, chlorosis, menoxenia, spontaneous perspiration, and night sweat. The components are prepared by decocting in a specific ratio, and the drug effects of the components are matched with each other, so that the synergistic effect is achieved.

In addition, the Chinese angelica has the functions of nourishing blood and warming and dredging blood vessels, so that the composition has a larger range of treating consumptive disease, for example, the Chinese date only has the functions of supplementing body fluid and stomach qi and cannot play a good role in treating blood, and the Chinese date is too greasy and can slow down the efficacy of the medicine. In addition, maltose has the function of nourishing body fluid, but the effect is not the same as that of the honey-fried licorice root added in the composition.

The traditional Chinese medicine composition is applied to preparation of medicines for harmonizing yin and yang, removing stagnation and tonifying deficiency.

Example 2

A traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 45g of cassia twig, 45g of astragalus, 120g of ginger (slice), 15g of angelica, 15g of honey-fried licorice root, 15g of ginseng (slice) and 30g of peony.

During preparation, 45g of cassia twig, 45g of astragalus, 120g of ginger, 15g of angelica, 15g of honey-fried licorice root, 15g of ginseng and 30g of peony are respectively weighed and added into a traditional Chinese medicine decocting tank together. Then 2000ml of water is added into the decocting pot to soak the traditional Chinese medicine raw materials for 30 min. Then heating the decocting pot with strong fire until boiling in the decocting pot, adjusting to small fire, and keeping the heating temperature at 100-. And (4) turning off the fire, filtering the solid-liquid mixture in the decocting pot, and removing the dregs to obtain 790ml of medicine juice.

Example 3

A traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15g of cassia twig, 240g of astragalus, 60g of ginger, 45g of angelica, 25g of honey-fried licorice root, 5g of ginseng and 10g of peony.

During preparation, 15g of cassia twig, 240g of astragalus, 60g of ginger (sliced), 45g of angelica, 25g of honey-fried licorice root, 5g of ginseng (sliced) and 10g of peony are respectively weighed and added into a traditional Chinese medicine decocting tank together. 3200ml of water is added into the decocting pot to soak the Chinese medicinal materials for 40 min. Then heating the decocting pot with strong fire until boiling in the decocting pot, adjusting to small fire, and keeping the heating temperature at 100-. Turning off the fire, filtering the solid-liquid mixture in the decocting pot, and removing the residue to obtain 1040ml of decoction.

Examples 4 to 15

The compositions of examples 4-15 have the specific compositions shown in Table 1, and the corresponding methods are the same as those of example 2.

TABLE 1

Examples of the experiments

Subject: the patients are 892 patients, wherein 395 male patients and 497 female patients are within the age range of 50-90 years, and all patients are clinically intolerant of cold and cold, abnormal cold and heat, hypodynamia and insufficient energy caused by the final development of various diseases.

The treatment mode comprises the following steps: the Chinese medicinal composition decoction is taken four times a day, 200ml of the Chinese medicinal composition decoction is taken every time for one week, and clinical curative effect observation is carried out. Raw shallot, seaweed, and woad should not be taken during administration.

The judgment standard of the curative effect is as follows: 1) cure, complete disappearance of symptoms and signs; 2) the effect is obvious, and most symptoms and signs disappear after treatment; 3) there was no relief or even a tendency for symptoms and signs to worsen.

And (3) counting the curative effect: according to statistics, 425 cured patients, 338 obviously effective patients and 129 ineffective patients in all experimental patients have the total effective rate of 85.5%.

According to the above experimental examples, it can be seen that: the traditional Chinese medicine composition has remarkable effects of harmonizing yin and yang, removing stagnation and tonifying deficiency under the mutual matching and synergistic effect of the specifically compatible traditional Chinese medicine components of cassia twig, astragalus membranaceus, ginger, angelica sinensis, honey-fried licorice root, ginseng and Chinese herbaceous peony, and is very suitable for clinical popularization and application. And can also be used for treating various chronic diseases such as gynecological diseases, male diseases, pediatric diseases, skin sore diseases and the like on the basis of corresponding overall pathogenesis by taking the main treatment conventional syndrome as a representative. Especially has definite curative effect on middle and late cancer patients and patients after radiotherapy and chemotherapy. Also suitable for people with cold body, asthenia, affection of exogenous solar-cold, wind-cold and damp pathogen, and lingering and unhealed.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent flow transformations made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

The traditional Chinese medicine composition is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 15-75 parts of cassia twig, 30-240 parts of astragalus, 60-180 parts of ginger, 10-45 parts of angelica, 5-25 parts of honey-fried licorice root, 5-25 parts of ginseng and 10-45 parts of peony.
The traditional Chinese medicine composition as claimed in claim 1, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of cassia twig, 160-220 parts of astragalus membranaceus, 80-100 parts of ginger, 10-15 parts of angelica sinensis, 10-15 parts of honey-fried licorice root, 10-15 parts of ginseng and 15-25 parts of peony.
The traditional Chinese medicine composition as claimed in claim 1, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 40-50 parts of cassia twig, 40-60 parts of astragalus, 125 parts of ginger 105-.
The traditional Chinese medicine composition as claimed in claim 1, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 55-65 parts of cassia twig, 70-140 parts of astragalus root, 160 parts of ginger 130-.
The traditional Chinese medicine composition as claimed in claim 3, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 45 parts of cassia twig, 45 parts of astragalus, 120 parts of ginger, 15 parts of angelica, 15 parts of honey-fried licorice root, 15 parts of ginseng and 30 parts of Chinese herbaceous peony.
A method for preparing the Chinese medicinal composition of any one of claims 1 to 5, comprising the steps of:

s1, mixing, namely weighing the traditional Chinese medicine raw materials of cassia twig, astragalus, ginger, angelica, honey-fried licorice root, ginseng and peony according to the mixture ratio;

s2, soaking, namely soaking the weighed traditional Chinese medicine raw materials in water;

s3, decocting, heating and decocting the soaked traditional Chinese medicine raw materials;

s4, filtering, and filtering after the decoction is finished to remove the dregs of a decoction to obtain the decoction.
The method of claim 6, wherein: in the step of S2 soaking, water is added according to the amount of 6-8 times of the total weight of the traditional Chinese medicine raw materials, and the traditional Chinese medicine raw materials are soaked for 20-40 min.
The method of claim 6, wherein: in the S3 decocting step, the mixture is heated to boiling and then continuously decocted for 60-90min at the temperature of 100-115 ℃.
The method of claim 6, wherein: in the step S4, the volume of the finally obtained medicine juice is 13/40-16/40 of the volume corresponding to the added water volume.
An application of the Chinese medicinal composition of any one of claims 1 to 5, which is characterized in that: the traditional Chinese medicine composition is applied to the preparation of medicines for regulating yin and yang, removing stagnation and tonifying deficiency.