CN111480839A - Special clinical nutrition formula for bone cancer and preparation method thereof - Google Patents

Special clinical nutrition formula for bone cancer and preparation method thereof Download PDF

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Publication number
CN111480839A
CN111480839A CN202010224734.3A CN202010224734A CN111480839A CN 111480839 A CN111480839 A CN 111480839A CN 202010224734 A CN202010224734 A CN 202010224734A CN 111480839 A CN111480839 A CN 111480839A
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parts
powder
bone cancer
arginine
selenium
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尤俊
季敬东
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Shanghai Own Medic High Tech Medical Industrial Co ltd
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Shanghai Own Medic High Tech Medical Industrial Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
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Abstract

The invention discloses a bone cancer special clinical nutrition formula and a preparation method thereof, wherein the formula comprises, by weight, 2-28 parts of carbohydrate, 10-45 parts of protein, 0.1-3 parts of arginine, 1-5 parts of glutamine, 0.2-0.5 part of β -hydroxy- β -calcium methylbutyrate, 0.1-2 parts of unsaturated fatty acid, 0.008-0.3 part of vitamin complex, 2.5-4 parts of selenium, 0.02-1 part of L-carnitine, 8-12 parts of yellow or green vegetables, 6-10 parts of dietary fiber, 0.03-3.5 parts of new resource food and 1-15 parts of medicinal and edible homologous components.

Description

Special clinical nutrition formula for bone cancer and preparation method thereof
Technical Field
The invention relates to the field of formula foods for special medical purposes, in particular to a special clinical nutritional formula for bone cancer and a preparation method thereof.
Background
Bone cancer, also known as bone tumor, refers to the condition of the skeletal system, as well as other organs, suffering from metastatic disease from any tissue component tumor or from other organs. Tumors affecting the bone may occur in bone cells, the hematopoietic component of bone, cartilage, and the fibrous or synovial component. Can be primary or transfer; either benign or malignant.
Benign bone tumors include osteochondroma, endogenetic chondroma, chondroblastoma, chondrosamyxoid fibroma, osteoid osteoma, non-ossified fibroma (fibrous cortical defects), benign bone giant cell tumors. The primary malignant bone tumor comprises multiple myeloma, osteosarcoma, fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's sarcoma, bone lymphoma, malignant giant cell tumor of bone, and chordoma.
Bone is one of the good sites of systemic metastases, accounting for 15% -20% of systemic metastases, and spinal metastases occur in about 36% of patients who die from malignant tumors. Primary bone and soft tissue tumors represent only 2% -3% of all tumors, 1/3 being a malignant tumor, most clinically definite diagnoses of which have already developed distant metastases.
Any tumor can metastasize to the bone, but cancer metastasis is most common, especially cancers that originate in tissues including breast, lung, prostate, kidney, thyroid, colon. Prostate cancer in men and breast cancer in women are the most common types of tumors. Lung cancer is the most common cause of neoplastic death in both men and women. Breast cancer is the most common of bone metastatic tumors. Any bone can be involved. However, the distal ends of the bones below the anterior and lower legs are less affected and, once metastasis occurs, it is most commonly from lung cancer, followed by kidney cancer. The symptoms of metastasis are often manifested as bone pain, but may also be asymptomatic for some time. Metastatic tumors of the bone may manifest symptoms before the primary tumor is detected, or may occur in patients who have been clearly diagnosed with cancer.
Bone cancer is high in incidence of teenagers. The famous children's surgical experts in China, professor Zhang jin Zheng, Chin institute of engineering, record in "practical children's oncology" compiled by him: osteosarcoma, the most common primary malignant bone tumor, occurs at one-to-three parts per million annually, with about three-quarters of the incidence occurring in the knee joint. Since the bone of the teenagers grows rapidly in this period, pain caused by bone cancer is easily mistaken by people as a normal physiological phenomenon, namely growth pain, or common arthritis, sprain and periostitis, and the optimal treatment time is missed.
Although the incidence rate of osteosarcoma is low, the osteosarcoma is extremely dangerous, the survival rate of patients in advanced stage is low, and the cancer cells of untreated osteodynia patients can have lung metastasis within half to one year, so that the patients die, and even after amputation, most of patients in advanced stage still die of the lung metastasis or multi-part bone metastasis of the cancer cells.
Due to the location and the range of involvement, the main treatment means of bone cancer is chemotherapy and radiotherapy followed by chemotherapy, tissue decomposition is accelerated and protein is lost, organ dysfunction and weight loss are caused, and then the incidence rate of complications and the death rate of the patients are increased, so that the bone cancer is one of high-risk factors influencing the recovery of the patients after the operation. Therefore, the nutritional support in the operation period must be strengthened, and the nutritional status of the patients must be improved, thereby reducing the occurrence of operation complications, prolonging the life time of the patients and improving the life quality of the patients.
Disclosure of Invention
The invention provides a special clinical nutrition formula for bone cancer, which solves the problems in the prior art, provides high-quality protein through reasonable diet blending, matches carbohydrate, dietary fiber, fat, n-3 and n-6 unsaturated fatty acid, selects various vitamins, mineral substances, medicine and food homologous and new resource food, and simultaneously supplies sufficient arginine, glutamine, probiotics and L-carnitine, relieves the clinical symptoms of patients, and improves the nutritional status of the patients.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a special clinical nutrition formula for bone cancer, which comprises the following components and parts by weight, 2-28 parts of carbohydrate, 10-45 parts of protein, 0.1-3 parts of arginine, 1-5 parts of glutamine, 0.2-0.5 part of β -hydroxy- β -calcium methylbutyrate, 0.1-2 parts of unsaturated fatty acid, 0.06-0.2 part of vitamin C, 0.008-0.015 part of vitamin A, 0.01-0.03 part of vitamin E, 2.5-4 parts of selenium, 0.02-1 part of L-carnitine, 8-12 parts of yellow or green vegetables, 6-10 parts of dietary fiber, 0.03-3.5 parts of new resource food and 1-15 parts of medicinal and edible homologous components.
Further, the carbohydrate comprises one or more of maltodextrin powder, sweet potato powder, enzymolysis rice flour and corn flour.
Further, the protein source comprises one or more of hydrolyzed whey protein powder, soybean protein isolate peptide, whole egg powder, albumin peptide, soybean peptide, marine fish oligopeptide, concentrated whey protein powder, bovine colostrum powder, whole milk powder, α -whey protein powder and lactoferrin.
Further, arginine includes one or more of L-arginine, L-arginine hydrochloride, and L-arginine-aspartic acid.
Further, the unsaturated fatty acid comprises one or more of n-3, n-6 and n-9 unsaturated fatty acids, and the source of the unsaturated fatty acid comprises one or more of fish oil microcapsule powder, linseed oil microcapsule powder, evening primrose oil microcapsule powder, olive oil microcapsule powder, chain triglyceride powder, docosahexaenoic acid oil, arachidonic acid oil and tea oil microcapsule powder.
Further, vitamin C includes one or more of L-ascorbic acid, L-calcium ascorbate, magnesium ascorbyl phosphate, L-sodium ascorbate, L-potassium ascorbate, and ascorbyl palmitate.
Further, vitamin a includes one or more of retinyl acetate, retinyl palmitate, all-trans retinol, and β -carotene.
Further, vitamin E includes one or more of d- α -tocopherol, dl- α -tocopherol, d- α -tocopheryl acetate, dl- α -tocopheryl acetate, mixed tocopherol concentrate, vitamin E calcium succinate, d- α -tocopheryl succinate, and dl- α -tocopheryl succinate.
Further, the yellow or green vegetables include one or more of Chinese cabbage, green vegetable, cucumber, broccoli and cabbage mustard.
Further, the new resource food at least comprises ginseng, inulin and probiotics, wherein the probiotics account for 0.01-0.08 part by weight of the total formula.
Furthermore, the probiotic bacteria are one or more of Bifidobacterium, Lactobacillus and Streptococcus, wherein the probiotic bacteria comprise one or more of Lactobacillus acidophilus NCFM, Bifidobacterium animalis Bb-12, Bifidobacterium lactis HN019, Bifidobacterium lactis Bi-07, Lactobacillus rhamnosus L GG, Lactobacillus rhamnosus HN001, Lactobacillus fermentum CECT5716 and Bifidobacterium breve M-16V.
Furthermore, the medicinal and edible components comprise one or more of fructus Jujubae, colla Corii Asini, fructus Lycii, Poria, Glycyrrhrizae radix, and rhizoma Dioscoreae.
Further, the dietary fiber comprises at least one of inulin, konjac flour, galacto-oligosaccharide, fructo-oligosaccharide, isomalto-oligosaccharide, soybean polysaccharide, cyclodextrin, resistant dextrin, and soybean fiber.
Further, selenium is derived from one or more of sodium selenite, sodium selenate, selenoprotein, selenium-rich edible fungus powder, L-selenium-methyl selenocysteine, and selenium-rich yeast.
The second aspect of the invention provides a preparation method of the special clinical nutrition formula for bone cancer, which comprises the following steps:
weighing predetermined amounts of raw materials, and grinding vitamins, yellow or green vegetables, dietary fibers, new resource food and medicinal and edible homologous components to prepare a premix;
step two, mixing and stirring the composite cellulose, the yellow or green vegetables, the dietary fiber, the new resource food and the premix of the medicinal and edible homologous components obtained in the step one with carbohydrate for 8-15 min;
step three, putting the mixture obtained in the step two and other materials into a mixing stirrer according to a gradually increasing principle, stirring for 18-22min, wherein the particle size of the final product is 10-100 mu m;
step four, inspecting the product obtained in the step three; and weighing, recording and repacking after the test is qualified.
Further, the stirring speed of the mixing stirrer is 100-200 r/min.
By adopting the technical scheme, compared with the prior art, the invention has the following technical effects:
1. the formulation of the present invention includes arginine, which causes tumor cells to switch from G0The number of the tumor cells entering the S phase is increased, and arginine can enhance the sensitivity of the tumor cells to chemotherapeutic drugs during chemotherapy, so that the tumor cells are killed to a greater extent.
2. The formula of the invention comprises glutamine, the glutamine is a respiratory fuel of rapid proliferation cells in human bodies and is a precursor for synthesizing nucleic acid and protein, amino acid which is necessary for the condition under the stress state of organisms caused by chemotherapy is favorable for cell proliferation, and the glutamine is supplemented to relieve permeability, reduce translocation of bacterial toxin and reduce infection; glutamine can limit the generation of cytokines and the infiltration of neutral polymorphonuclear cells, thereby reducing the permeability of intercellular tight junctions caused by the migration of the cells along chemotactic gradients and playing a role in protecting mucosal structures. The structural and functional integrity of organelles is maintained by supplementing energy and improving metabolism, and the ultrastructure of mucosal cells is protected from being damaged.
3. The formula of the invention comprises unsaturated fatty acid, and the unsaturated fatty acid inhibits the expression of inflammatory cytokines and relieves mucosal injury.
4. The formula of the invention comprises selenium, and selenium supplement can restore the oxidation resistance of mesenchymal cells of bone marrow and avoid oxidation damage and cell mutation. Animals deficient in selenium have diminished antioxidant capacity and are not conducive to the reconstruction of the normal fine structure of the bone. An increased intake of selenium is positively correlated with a decreased incidence of tumor.
5. The formula of the invention comprises probiotics, and timely supplement of the probiotics has important significance for preventing and treating systemic infection, systemic inflammatory response syndrome and multiple organ dysfunction syndrome caused by intestinal flora imbalance during chemotherapy.
6. The formula of the invention comprises new resource food and medicinal and edible components, and can regulate the immune function of organisms, inhibit the proliferation of tumor cells, induce the apoptosis of the tumor cells, inhibit the telomerase activity of the tumor cells, up-regulate the protein expression level, increase the bone density and the bone mass, inhibit the increase and expansion of osteoclasts and bone tumor cells, and regulate the metabolism of the bone cells.
In conclusion, aiming at the poor current situations of unreasonable dietary structure, unbalanced nutrition and the like of a patient body caused by bone cancer treatment, the special clinical nutrition formula for bone cancer mainly provides high-quality protein through reasonable diet blending, matches carbohydrate, dietary fiber and unsaturated fatty acid, selects various vitamins, mineral substances, medicinal and edible homologous and new resource foods, and simultaneously supplies sufficient arginine, glutamine, probiotics and L-carnitine, so that the clinical symptoms of the patient are relieved, and the nutritional status of the patient is improved. By improving the nutritional status of patients with bone cancer, the adverse reaction during chemotherapy is reduced, and the prognosis of patients is improved. The subsequent reasonable nutrition support simultaneously regulates the abnormal metabolism of the tumor, inhibits the growth of the tumor and finally prolongs the survival time of the patient.
Detailed Description
The invention provides a special clinical nutrition formula for bone cancer, which comprises the following components, by weight, 2-28 parts of carbohydrate, 10-45 parts of protein, 0.1-3 parts of arginine, 1-5 parts of glutamine, 0.2-0.5 part of β -hydroxy- β -calcium methylbutyrate, 0.1-2 parts of unsaturated fatty acid, 0.06-0.2 part of vitamin C, 0.008-0.015 part of vitamin A, 0.01-0.03 part of vitamin E, 2.5-4 parts of selenium, 0.02-1 part of L-carnitine, 8-12 parts of yellow or green vegetables, 6-10 parts of dietary fiber, 0.03-3.5 parts of new resource food and 1-15 parts of medicinal and edible homologous components.
The novel health-care food comprises a carbohydrate, a dietary fiber, a new resource food, a probiotic, a lactobacillus powder, a lactobacillus acidophilus NCFM, a bifidobacterium animalis Bb-12, bifidobacterium lactis Bi-07, lactobacillus rhamnosus L GG, lactobacillus rhamnosus 001, a lactobacillus ceCT5716, bifidobacterium breve M-16V, one or more of medicinal and edible ingredients of donkey-hide gelatin, yam, Chinese yam, poria, jujube, and jujube, wherein the arginine comprises one or more of L-arginine, L-arginine hydrochloride and L-arginine-aspartic acid, the yellow or green vegetable comprises one or more of Chinese cabbage, green vegetable, cucumber, cauliflower and cabbage, the dietary fiber comprises at least one of inulin, konjac powder, galactooligosaccharide, fructo-oligosaccharide, isomaltose oligosaccharide, soybean polysaccharide, cyclodextrin, resistant dextrin and soybean fiber, the new resource food at least comprises ginseng, inulin and probiotic, the probiotic accounts for 0.01-0.0.08 parts by weight of the total formula, comprises one or more of bifidobacterium, lactobacillus, streptococcus, lactobacillus acidophilus NCFM, bifidobacterium animalis Bb-12, bifidobacterium lactis Bi-07, bifidobacterium lactis HN, jujube, and/or a combination of medicinal and jujube.
The present invention will be described in detail and specifically with reference to the following examples to facilitate better understanding of the present invention, but the following examples do not limit the scope of the present invention.
Example 1
This example provides a preferred clinical nutritional formula for a specific type of bone cancer, which comprises the following components (as described in table 1) per 100 g:
TABLE 1 Special clinical nutrition formulation table for bone cancer
Components Weight (g)
Malt dextrin powder 28
Protein 35.5
Arginine 0.67
Glutamine 1.7
β -hydroxy- β -methylbutyrate calcium 0.4
Unsaturated fatty acid 0.8
Vitamin C 0.15
Vitamin A 0.01
Vitamin E 0.03
Selenium 3.2
L-carnitine 0.5
Cabbage 6
Chinese cabbage 4
Isomaltooligosaccharide 6
Ginseng radix 2
Lactobacillus acidophilus NCFM 0.01
Bifidobacterium breve M-16V 0.03
Red date 1
Chinese yam 10
Example 2
This example provides a preferred clinical nutritional formula for bone cancer and a method for preparing the same, each 100g of which comprises the following components (as shown in table 2):
TABLE 2 clinic nutrition formulation table for bone cancer
Components Weight (g)
Malt dextrin powder 25
Protein 36.5
Arginine 0.2
Glutamine 3
β -hydroxy- β -methylbutyrate calcium 0.2
Unsaturated fatty acid 0.8
Vitamin C 0.1
Vitamin A 0.01
Vitamin E 0.03
Selenium 2.5
L-carnitine 0.6
Chinese kale 6
Cucumber (Cucumis sativus) 6
Konjak powder 10
Inulin powder 3
Lactobacillus fermentum CECT5716 0.03
Bifidobacterium breve M-16V 0.03
Donkey-hide gelatin 4
Chinese wolfberry 2
Example 3
This example provides a preferred clinical nutritional formula for bone cancer and a method for preparing the same, each 100g of which comprises the following components (as shown in table 3):
TABLE 3 Special clinical nutrition formulation table for bone cancer
Components Weight (g)
Enzymolysis rice flour 25.5
Protein 27.6
Arginine 0.8
Glutamine 2
β -hydroxy- β -methylbutyrate calcium 0.4
Unsaturated fatty acid 1.3
Vitamin C 0.2
Vitamin A 0.008
Vitamin E 0.022
Selenium 3.1
L-carnitine 0.03
Cabbage 4
Cauliflower 8
Cyclodextrin 10
Ginseng radix 2
Lactobacillus acidophilus NCFM 0.01
Bifidobacterium breve M-16V 0.03
Red date 2
Chinese yam 13
Example 4
The embodiment provides a preparation method of the special clinical nutrition formula for bone cancer, which comprises the following steps:
weighing predetermined amounts of raw materials, and grinding vitamins, yellow or green vegetables, dietary fibers, new resource food and medicinal and edible homologous components to prepare a premix;
step two, mixing and stirring the composite cellulose, the yellow or green vegetables, the dietary fiber, the new resource food and the premix of the medicinal and edible homologous components obtained in the step one with carbohydrate for 10 min;
step three, putting the mixture obtained in the step two and other materials into a mixing stirrer according to a gradually increasing principle, stirring for 20min, and enabling the particle size of the final product to be 100 mu m;
step four, inspecting the product obtained in the step three; and weighing, recording and repacking after the test is qualified.
The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.

Claims (10)

1. The clinical nutrition formula special for bone cancer is characterized by comprising, by weight, 2-28 parts of carbohydrate, 10-45 parts of protein, 0.1-3 parts of arginine, 1-5 parts of glutamine, 0.2-0.5 part of β -hydroxy- β -calcium methylbutyrate, 0.1-2 parts of unsaturated fatty acid, 0.06-0.2 part of vitamin C, 0.008-0.015 part of vitamin A, 0.01-0.03 part of vitamin E, 2.5-4 parts of selenium, 0.02-1 part of L-carnitine, 8-12 parts of yellow or green vegetables, 6-10 parts of dietary fiber, 0.03-3.5 parts of new resource food and 1-15 parts of medicinal and edible components.
2. The clinical nutritional formula for bone cancer according to claim 1, wherein the carbohydrate comprises one or more of maltodextrin powder, sweet potato powder, enzymatic rice flour and corn flour.
3. The clinical nutritional formula for bone cancer patients according to claim 1, wherein the protein source comprises one or more of hydrolyzed whey protein powder, soy protein isolate peptide, whole egg powder, albumin peptide, soy peptide, marine fish oligopeptide, concentrated whey protein powder, bovine colostrum powder, whole milk powder, α -whey protein powder and lactoferrin.
4. The bone cancer-specific clinical nutritional formulation according to claim 1, wherein the arginine comprises one or more of L-arginine, L-arginine hydrochloride, and L-arginine-aspartic acid.
5. The clinical nutritional formula for bone cancer according to claim 1, wherein the unsaturated fatty acid comprises one or more of n-3, n-6 and n-9 unsaturated fatty acids, and the source of the unsaturated fatty acid comprises one or more of fish oil microcapsule powder, linseed oil microcapsule powder, evening primrose oil microcapsule powder, olive oil microcapsule powder, chained triglyceride powder, docosahexaenoic acid oil, arachidonic acid oil and tea oil microcapsule powder.
6. The clinical nutritional formula special for bone cancer according to claim 1, wherein the new resource food at least comprises ginseng, inulin and probiotics, and the probiotics accounts for 0.01-0.08 part by weight of the total formula.
7. The bone cancer specific clinical nutritional formula of claim 6, wherein the probiotic comprises one or more of lactobacillus acidophilus NCFM, bifidobacterium animalis Bb-12, bifidobacterium lactis HN019, bifidobacterium lactis Bi-07, lactobacillus rhamnosus L GG, lactobacillus rhamnosus HN001, lactobacillus fermentum CECT5716, bifidobacterium breve M-16V.
8. The special clinical nutritional formula for bone cancer according to claim 1, wherein the medicinal and edible components comprise one or more of red date, donkey-hide gelatin, medlar, tuckahoe, liquorice and Chinese yam.
9. The bone cancer-specific clinical nutritional formula according to claim 1, wherein the selenium is derived from one or more of sodium selenite, sodium selenate, selenoprotein, selenium-enriched edible mushroom powder, L-selenium-methylselenocysteine, and selenium-enriched yeast.
10. A method for preparing the clinical nutritional formulation for bone cancer according to any one of claims 1 to 9, comprising the steps of:
weighing predetermined amounts of raw materials, and grinding vitamins, yellow or green vegetables, dietary fibers, new resource food and medicinal and edible homologous components to prepare a premix;
step two, mixing and stirring the composite cellulose, the yellow or green vegetables, the dietary fiber, the new resource food and the premix of the medicinal and edible homologous components obtained in the step one with carbohydrate for 8-15 min;
step three, putting the mixture obtained in the step two and other materials into a mixing stirrer according to a gradually increasing principle, stirring for 18-22min, wherein the particle size of the final product is 10-100 mu m;
step four, inspecting the product obtained in the step three; and weighing, recording and repacking after the test is qualified.
CN202010224734.3A 2020-03-26 2020-03-26 Special clinical nutrition formula for bone cancer and preparation method thereof Pending CN111480839A (en)

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