CN111513332A - Special clinical nutrition formula for colorectal cancer and preparation method thereof - Google Patents

Special clinical nutrition formula for colorectal cancer and preparation method thereof Download PDF

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CN111513332A
CN111513332A CN202010481258.3A CN202010481258A CN111513332A CN 111513332 A CN111513332 A CN 111513332A CN 202010481258 A CN202010481258 A CN 202010481258A CN 111513332 A CN111513332 A CN 111513332A
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尤俊
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Shanghai Own Medic High Tech Medical Industrial Co ltd
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Abstract

The invention is suitable for the technical field of enteral nutrition, and provides a special clinical nutritional formula for colorectal cancer and a preparation method thereof, wherein the formula comprises a microecological preparation, dietary fibers, selenium, high-quality protein, fat, a vitamin C preparation, a vitamin A preparation, a vitamin E preparation, L-glutamine, rhizoma polygonati, ginseng, astragalus membranaceus, angelica sinensis and donkey-hide gelatin. Simultaneously supply sufficient arginine, glutamine, probiotics and L-carnitine. Through reasonable nutrition treatment, the erosion effect of gastric acid and food on mucous membrane can be reduced, the healing of ulcer surface is promoted, the disease recurrence is prevented, and the nutritional state of patients is improved.

Description

Special clinical nutrition formula for colorectal cancer and preparation method thereof
Technical Field
The invention belongs to the technical field of enteral nutrition, and particularly relates to a special clinical nutritional formula for colorectal cancer and a preparation method thereof.
Background
Colorectal cancer is one of the common malignancies in humans, including colon and rectal cancers, with morbidity and mortality rates third place in malignancies. Every year >100 million people are diagnosed with colorectal cancer, and 136 million people worldwide are affected, accounting for nearly 10% of cancers. Particularly, in recent years, with the improvement of the living standard and the change of the dietary structure of China, the high-fat and high-protein diet seriously affects the living quality of Chinese people along with the annual increase of the incidence and mortality of large intestine cancer, and the incidence of large intestine cancer in China is increased year by year and gradually shows a trend of 'youthfulness'.
The diet of chemotherapy patients after colorectal cancer surgery follows the principle of reasonable dietary structure, timing and quantification and small amount of multiple meals so as to promote digestion and absorption and improve the appetite and nutritional status of patients. Therefore, the nutrition condition, the immune function and the life quality of the patients with advanced colorectal cancer chemotherapy are reasonably and effectively intervened and improved. The nutritional intervention can effectively improve the living quality of the patient with advanced colorectal cancer without increasing the economic burden of the patient. Quality of life plays an important role in the management of symptoms in cancer patients.
Disclosure of Invention
The invention provides a special clinical nutritional formula for colorectal cancer and a preparation method thereof, and aims to provide high-quality protein, carbohydrate and unsaturated fatty acid through reasonable dietary blending aiming at the poor current situation of unbalanced nutrition of patients caused by colorectal cancer, select various vitamins, minerals, medicinal and edible foods and new resource foods, relieve clinical symptoms of patients and improve the nutritional status of the patients. Simultaneously supply sufficient arginine, glutamine, probiotics and L-carnitine. Through reasonable nutrition treatment, the erosion effect of gastric acid and food on mucous membrane can be reduced, the healing of ulcer surface is promoted, the disease recurrence is prevented, and the nutritional state of patients is improved.
The special clinical nutrition formula for the colorectal cancer comprises the following components in parts by weight: 800-1000 g of microecological preparation, 800-1000 g of dietary fiber, 100-200 g of selenium, 900-1000 g of high-quality protein, 900-1000 g of fat, 400-500 g of vitamin C preparation, 800-900 g of vitamin A preparation, 400-500 g of vitamin E preparation, 1500-1700 g of L-glutamine, 900-1100 g of rhizoma polygonati, 700-900 g of ginseng, 700-900 g of astragalus mongholicus, 700-900 g of angelica sinensis and 700-900 g of donkey-hide gelatin.
Preferably, the microecological agent is a composition of one or more of Bifidobacterium, Lactobacillus, Streptococcus, Lactobacillus acidophilus NCFM, Bifidobacterium animalis Bb-12, Bifidobacterium lactis HN019, Bifidobacterium lactis Bi-07, Lactobacillus rhamnosus LGG, Lactobacillus rhamnosus HN001, Lactobacillus fermentum CECT5716, and Bifidobacterium breve M-16V.
Preferably, the dietary fiber is one or more of inulin, polydextrose, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide, isomalto-oligosaccharide, resistant dextrin, soybean fiber, etc.
Preferably, the high-quality protein is one or more of hydrolyzed whey protein powder, soybean protein isolate peptide, whole egg powder, albumin peptide, soybean peptide, marine fish oligopeptide, concentrated whey protein powder, bovine colostrum powder, whole milk powder, alpha-whey protein powder and lactoferrin.
Preferably, the fat is one or more of fish oil microcapsule powder, linseed oil microcapsule powder, evening primrose oil microcapsule powder, olive oil microcapsule powder, medium chain triglyceride powder, docosahexaenoic acid oil, arachidonic acid oil, and tea oil microcapsule powder.
Preferably, the vitamin C preparation is one or more of L-ascorbic acid, L-calcium ascorbate, L-sodium ascorbate, L-potassium ascorbate, magnesium ascorbyl phosphate and L-ascorbic acid-6-palmitate;
the vitamin A preparation is one or more of retinyl acetate, retinyl palmitate, all-trans retinol, and beta-carotene;
vitamin E is one or more of d-alpha-tocopherol, dl-alpha-tocopherol, d-alpha-tocopherol acetate, dl-alpha-tocopherol acetate, mixed tocopherol concentrate, vitamin E calcium succinate, d-alpha-tocopherol succinate, and dl-alpha-tocopherol succinate.
Preferably, the selenium is added in the form of one or more of sodium selenite, selenium-enriched yeast, and L-selenium-methylselenocysteine.
The invention also provides a preparation method of the special clinical nutrition formula for colorectal cancer, which is suitable for any one of the special clinical nutrition formulas for colorectal cancer, and comprises the following steps:
s1, weighing the vitamin C preparation, the vitamin A preparation and the vitamin E preparation according to the weight, and premixing to obtain the compound vitamin; weighing rhizoma Polygonati, Ginseng radix, radix astragali, radix Angelicae sinensis, and colla Corii Asini by weight, and premixing to obtain medicinal and edible premix; weighing the microecologics, the dietary fibers, the high-quality protein, the fat and the L-glutamine according to the weight, and premixing to obtain a food raw material mixture; weighing selenium according to weight;
s2, mixing the compound vitamins, the medicinal and edible premix, the food raw material mixture and selenium with 2% of hydrolyzed whey protein powder for 10 minutes, sequentially putting into a mixer, and mixing for twenty minutes to obtain the special clinical nutritional food for the colorectal cancer;
s3, weighing the nutritional food obtained in the step S2, and subpackaging into 10-65 g/bottle.
Compared with the prior art, the invention has the beneficial effects that: aiming at the poor current situation that nutrition imbalance and the like of a patient are caused by colorectal cancer, the special clinical nutritional formula for colorectal cancer and the preparation method thereof provided by the invention mainly provide high-quality protein, carbohydrate and unsaturated fatty acid through reasonable dietary blending, and select various vitamins, minerals, medicinal and edible foods and new resource foods, so that the clinical symptoms of the patient are relieved, and the nutritional status of the patient is improved. Simultaneously supply sufficient arginine, glutamine, probiotics and L-carnitine. Through reasonable nutrition treatment, the erosion effect of gastric acid and food on mucous membrane can be reduced, the healing of ulcer surface is promoted, the disease recurrence is prevented, and the nutritional state of patients is improved.
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Fig. 1 is a flow chart of a preparation method of the special clinical nutrition formula for colorectal cancer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The invention provides a technical scheme that: the special clinical nutrition formula for the colorectal cancer and the preparation method thereof comprise the following components by weight: 800-1000 g of microecological preparation, 800-1000 g of dietary fiber, 100-200 g of selenium, 900-1000 g of high-quality protein, 900-1000 g of fat, 400-500 g of vitamin C preparation, 800-900 g of vitamin A preparation, 400-500 g of vitamin E preparation, 1500-1700 g of L-glutamine, 900-1100 g of rhizoma polygonati, 700-900 g of ginseng, 700-900 g of astragalus mongholicus, 700-900 g of angelica sinensis and 700-900 g of donkey-hide gelatin.
Wherein the microecological preparation is one or more of Bifidobacterium, Lactobacillus, Streptococcus, Lactobacillus acidophilus NCFM, Bifidobacterium animalis Bb-12, Bifidobacterium lactis HN019, Bifidobacterium lactis Bi-07, Lactobacillus rhamnosus LGG, Lactobacillus rhamnosus HN001, Lactobacillus fermentum CECT5716, and Bifidobacterium breve M-16V. The constituents of the microecological preparation are all probiotics, which are either normal flora capable of surviving in the intestinal ecosystem or foreign bacteria with regulatory and beneficial effects. The mechanism of protective action of probiotics on intestinal barrier function is as follows: the antagonistic action of the permanent planting, the balance of intestinal flora and the inhibition of the reproduction of pathogenic bacteria. ② the expression of the intestinal tight junction related protein is promoted. And thirdly, improving the intestinal immunity and enhancing the organism immunity. Fourthly, timely eliminating intestinal carcinogens, promoting the release of anti-cancer substances and inducing the apoptosis of tumor cells. Therefore, timely supplement of probiotics has important significance for preventing and treating systemic infection, systemic inflammatory response syndrome and multiple organ dysfunction syndrome caused by intestinal flora imbalance during chemotherapy.
The dietary fiber is one or more of inulin, polydextrose, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide, isomalto-oligosaccharide, resistant dextrin, soybean fiber, etc. The high-quality protein is one or more of hydrolyzed whey protein powder, soybean protein isolate peptide, whole egg powder, albumin peptide, soybean peptide, marine fish oligopeptide, concentrated whey protein powder, bovine colostrum powder, whole milk powder, alpha-whey protein powder and lactoferrin. The intake of the total dietary fiber of the colorectal cancer patients is obviously lower than that of the common people. The intake of a large amount of dietary fibers, particularly cereal fibers and whole grains, can increase colon contents, can dilute carcinogenic substances in the large intestine, and the high cellulose can stimulate the intestinal wall, increase the peristalsis frequency and shorten the retention time of excrement in the intestinal tract, thereby shortening the action time of intestinal mucosa and carcinogenic substances and reducing the risk of the large intestine cancer. Meanwhile, the time for stimulating the intestinal epithelial cells by the bile acid is reduced, and the canceration probability of the large intestinal epithelial cells can be reduced. Increasing dietary fiber intake can affect the intestinal flora composition of colorectal cancer patients. The intake of dietary fiber should be both guaranteed to reach the daily recommended amount and reasonably selected.
The repair of the colorectal cancer wound surface needs protein participation, so that enough protein needs to be taken to meet the nutritional requirements of the body, and the amount of the taken protein needs to be taken. The rich high biological value high quality protein is supplemented, the high quality protein is beneficial to the absorption and utilization of a human body digestive absorption system, 8 necessary amino acids required by the human body are comprehensively and evenly supplemented, otherwise negative nitrogen balance is easy to occur, and the immunity is improved. The high-quality protein is one or more of hydrolyzed whey protein powder, soybean protein isolate peptide, whole egg powder, albumin peptide, soybean peptide, marine fish oligopeptide, concentrated whey protein powder, bovine colostrum powder, whole milk powder, alpha-whey protein powder and lactoferrin.
In order to reduce the burden of the intestinal tract, the unsaturated fatty acids n-3, n-6 and n-9 inhibit the expression of inflammatory cytokines and reduce the damage of the intestinal mucosa. The fat is one or more of fish oil microcapsule powder, oleum Lini microcapsule powder, oleum Oenotherae Erythrosepalae microcapsule powder, oleum Olivarum microcapsule powder, medium chain triglyceride powder, docosahexaenoic acid oil, arachidonic acid oil, and oleum Camelliae microcapsule powder.
The selenium is added in the form of one or more of sodium selenite, selenium-enriched yeast, and L-selenium-methyl selenocysteine. Selenium is used as an active center of various antioxidant enzymes in vivo, can protect DNA, protein and other cell components from oxidative damage, and is also one of important tumor prevention medicaments. The immune function is also obviously improved along with the rise of the blood selenium level after the selenium supplement, the expression level of selenoprotein-P in colorectal cancer tumor tissues is obviously higher than the plasma concentration of selenoprotein-P, and meanwhile, the selenoprotein possibly enters the tumor tissues from the plasma to play an anticancer role.
In addition, vitamin C preparations are acidic and should not be taken too much, but they help promote healing of the ulcer surface, and supplementary routes and dosages should be considered clinically as appropriate for the particular condition. The vitamin C preparation is one or more of L-ascorbic acid, L-calcium ascorbate, L-sodium ascorbate, L-potassium ascorbate, magnesium ascorbyl phosphate, and L-ascorbic acid-6-palmitate.
Vitamin A is fat-soluble vitamin. The fat-soluble vitamins can promote the healing of ulcer surface and improve the disease resistance of organism. The vitamin A preparation is one or more of retinyl acetate, retinyl palmitate, all-trans retinol, and beta-carotene.
Vitamin E can directly scavenge free radicals and protect cell membrane. Vitamin E can also transfer electrons to free radicals, thereby reducing the lipid peroxidation in the mucous membrane caused by the free radicals and protecting the mucous membrane. Meanwhile, the vitamin E can also maintain the integrity of a nerve biomembrane and prevent peripheral neurons in intestinal mucosa from being attacked by excitotoxic injury and free radicals. Vitamin E is one or more of d-alpha-tocopherol, dl-alpha-tocopherol, d-alpha-tocopherol acetate, dl-alpha-tocopherol acetate, mixed tocopherol concentrate, vitamin E calcium succinate, d-alpha-tocopherol succinate, and dl-alpha-tocopherol succinate.
L-glutamine plays an important role in maintaining intestinal metabolism, structure and function. Not only can be used as a substrate for intestinal mucosa cell energy metabolism, but also can provide raw materials for rapidly circulating protein and nucleic acid. Can provide energy for various rapidly dividing cells such as intestinal mucosa epithelial cells, activated lymphocytes and the like, and play an irreplaceable important role of other amino acids in promoting the repair of damaged intestinal tracts and maintaining normal local immune functions.
Rhizoma Polygonati is neutral in nature and sweet in taste, and has immunity regulating and anti-tumor effects. Ginsenoside in Ginseng radix can act on immune organ, immune cell and immune molecule, and panaxan can increase weight of immune organ, stimulate differentiation and maturation of immune cell, and improve specific and nonspecific immunity. Radix astragali can improve humoral immunity and cellular immunity, and recover disordered immune function. The radix Angelicae sinensis can improve immunity by inducing interferon, promoting macrophage phagocytosis, activating T cell, and promoting interleukin 2 production. The donkey-hide gelatin can play a role in immunoregulation by regulating the immunity of body fluid and the phagocytic function of macrophages.
Then preparing special clinical nutritional food for colorectal cancer according to the following steps:
s1, weighing the vitamin C preparation, the vitamin A preparation and the vitamin E preparation according to the weight, and premixing to obtain the compound vitamin; weighing rhizoma Polygonati, Ginseng radix, radix astragali, radix Angelicae sinensis, and colla Corii Asini by weight, and premixing to obtain medicinal and edible premix; weighing the microecologics, the dietary fibers, the high-quality protein, the fat and the L-glutamine according to the weight, and premixing to obtain a food raw material mixture; weighing selenium according to weight.
S2, mixing the compound vitamins, the medicinal and edible premix, the food raw material mixture and selenium with 2% hydrolyzed whey protein powder for 10 minutes, sequentially putting into a mixer, and mixing for twenty minutes to obtain the special clinical nutritional food for the colorectal cancer.
S3, weighing the nutritional food obtained in the step S2, and subpackaging into 10-65 g/bottle.
In conclusion, the diet of the chemotherapy patients after colorectal cancer operation needs to follow the principle of reasonable dietary structure, regular and quantitative diet and small amount of multiple meals so as to promote digestion and absorption and improve the appetite and nutritional status of the patients. Therefore, the nutrition condition, the immune function and the life quality of the patients with advanced colorectal cancer chemotherapy are reasonably and effectively intervened and improved. The nutritional intervention can effectively improve the living quality of the patient with advanced colorectal cancer without increasing the economic burden of the patient. Quality of life plays an important role in the management of symptoms in cancer patients.
Aiming at the poor current situation that nutrition imbalance and the like of a patient are caused by colorectal cancer, the special clinical nutritional formula for colorectal cancer and the preparation method thereof provided by the invention mainly provide high-quality protein, carbohydrate and unsaturated fatty acid through reasonable dietary blending, and select various vitamins, minerals, medicinal and edible foods and new resource foods, so that the clinical symptoms of the patient are relieved, and the nutritional status of the patient is improved. Simultaneously supply sufficient arginine, glutamine, probiotics and L-carnitine. Through reasonable nutrition treatment, the erosion effect of gastric acid and food on mucous membrane can be reduced, the healing of ulcer surface is promoted, the disease recurrence is prevented, and the nutritional state of patients is improved.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (8)

1. The special clinical nutrition formula for the colorectal cancer is characterized in that: comprising the following components in weight: 800-1000 g of microecological preparation, 800-1000 g of dietary fiber, 100-200 g of selenium, 900-1000 g of high-quality protein, 900-1000 g of fat, 400-500 g of vitamin C preparation, 800-900 g of vitamin A preparation, 400-500 g of vitamin E preparation, 1500-1700 g of L-glutamine, 900-1100 g of rhizoma polygonati, 700-900 g of ginseng, 700-900 g of astragalus mongholicus, 700-900 g of angelica sinensis and 700-900 g of donkey-hide gelatin.
2. The special clinical nutritional formula for colorectal cancer according to claim 1, wherein:
the microecological preparation is one or more of Bifidobacterium, Lactobacillus, Streptococcus, Lactobacillus acidophilus NCFM, Bifidobacterium animalis Bb-12, Bifidobacterium lactis HN019, Bifidobacterium lactis Bi-07, Lactobacillus rhamnosus LGG, Lactobacillus rhamnosus HN001, Lactobacillus fermentum CECT5716, and Bifidobacterium breve M-16V.
3. The special clinical nutritional formula for colorectal cancer according to claim 1, wherein: the dietary fiber is one or more of inulin, polydextrose, galacto-oligosaccharide, fructo-oligosaccharide, xylo-oligosaccharide, isomalto-oligosaccharide, resistant dextrin, soybean fiber, etc.
4. The special clinical nutritional formula for colorectal cancer according to claim 1, wherein: the high-quality protein is one or more of hydrolyzed whey protein powder, soybean protein isolate peptide, whole egg powder, albumin peptide, soybean peptide, marine fish oligopeptide, concentrated whey protein powder, bovine colostrum powder, whole milk powder, alpha-whey protein powder and lactoferrin.
5. The special clinical nutritional formula for colorectal cancer according to claim 1, wherein: the fat is one or more of fish oil microcapsule powder, oleum Lini microcapsule powder, oleum Oenotherae Erythrosepalae microcapsule powder, oleum Olivarum microcapsule powder, medium chain triglyceride powder, docosahexaenoic acid oil, arachidonic acid oil, and oleum Camelliae microcapsule powder.
6. The special clinical nutritional formula for colorectal cancer according to claim 1, wherein:
the vitamin C preparation is one or more of L-ascorbic acid, L-calcium ascorbate, L-sodium ascorbate, L-potassium ascorbate, magnesium ascorbyl phosphate, and L-ascorbic acid-6-palmitate;
the vitamin A preparation is one or more of retinyl acetate, retinyl palmitate, all-trans retinol, and beta-carotene;
vitamin E is one or more of d-alpha-tocopherol, dl-alpha-tocopherol, d-alpha-tocopherol acetate, dl-alpha-tocopherol acetate, mixed tocopherol concentrate, vitamin E calcium succinate, d-alpha-tocopherol succinate, and dl-alpha-tocopherol succinate.
7. The special clinical nutritional formula for colorectal cancer according to claim 1, wherein: the selenium is added in the form of one or more of sodium selenite, selenium-enriched yeast, and L-selenium-methyl selenocysteine.
8. The method for preparing a clinical nutritional formula for colorectal cancer according to claims 1 to 7, wherein the clinical nutritional formula comprises: the method comprises the following steps:
s1, weighing the vitamin C preparation, the vitamin A preparation and the vitamin E preparation according to the weight, and premixing to obtain the compound vitamin; weighing rhizoma Polygonati, Ginseng radix, radix astragali, radix Angelicae sinensis, and colla Corii Asini by weight, and premixing to obtain medicinal and edible premix; weighing the microecologics, the dietary fibers, the high-quality protein, the fat and the L-glutamine according to the weight, and premixing to obtain a food raw material mixture; weighing selenium according to weight;
s2, mixing the compound vitamins, the medicinal and edible premix, the food raw material mixture and selenium with 2% of hydrolyzed whey protein powder for 10 minutes, sequentially putting into a mixer, and mixing for twenty minutes to obtain the special clinical nutritional food for the colorectal cancer;
s3, weighing the nutritional food obtained in the step S2, and subpackaging into 10-65 g/bottle.
CN202010481258.3A 2020-05-31 2020-05-31 Special clinical nutrition formula for colorectal cancer and preparation method thereof Pending CN111513332A (en)

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CN110720628A (en) * 2019-11-07 2020-01-24 上海奥医生物医药科技有限公司 Special clinical nutrition formula for protecting chemotherapy-damaged intestinal mucosa barrier function and preparation method thereof
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CN110226741A (en) * 2019-06-20 2019-09-13 上海奥医生物医药科技有限公司 A kind of ulcerative colitis tailored version clinical nutrition formula and preparation method thereof
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