CN107981339A - Tumour full nutrition formula food - Google Patents

Tumour full nutrition formula food Download PDF

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CN107981339A
CN107981339A CN201711287325.2A CN201711287325A CN107981339A CN 107981339 A CN107981339 A CN 107981339A CN 201711287325 A CN201711287325 A CN 201711287325A CN 107981339 A CN107981339 A CN 107981339A
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tumor
parts
vitamin
nutritionally complete
formula food
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李跃辉
彭艳梅
覃元清
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Hunan Special Medical Formula Food Co Ltd
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Hunan Special Medical Formula Food Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

The present invention provides a kind of tumour full nutrition formula food, includes the material of following parts by weight：8.25 17 parts of 47 126 parts of nutrient matrix, 0.13 0.71 parts of nutrition fortifier, 2.5 7.5 parts of composite mineral matter, 0.1 1.0 parts of multi-vitamins and Chinese medical extract；The Chinese medical extract includes at least one of material of following parts by weight：36 parts of 0.25 0.75 parts of ganoderma lucidum polysaccharide, 0.75 1.25 parts of astragalus polyose, 0.25 0.75 parts of tea polyphenols, 3.75 7.5 parts of dandelion extract, 0.25 0.75 parts of milk thistle extract and Rhizoma Fagopyri Dibotryis extract.

Description

Full-nutrition formula food for tumors
Technical Field
The invention relates to the field of formula foods with special medical application, in particular to a full-nutrition formula food for tumors.
Background
The tumor is an abnormal lesion formed by clonal abnormal hyperplasia caused by that certain cells of local tissues lose normal regulation and control on the growth of the local tissues on the gene level under the action of various carcinogenic factors of an organism. The incidence of malnutrition associated with weight loss in tumor patients is quite high due to factors such as tumor consumption, disturbance of the own metabolism, tumor effects on appetite and mental depression. 15112 cases of malignant tumor patients are investigated by the committee on Nutrition and support therapy of the national anticancer Association, and the result shows that the incidence rate of malnutrition of the malignant tumor patients is as high as 67%. Malnutrition will significantly increase tumor complications and mortality, prolong hospitalization time, and increase hospitalization costs.
The metabolism of tumor patients is different from that of normal persons, and the energy consumption of tumor patients is increased compared with that of normal persons. The reasons for the increase in energy consumption are two: firstly, the tumor itself needs a large amount of energy in the process of rapid cell division and tumor growth; secondly, some substances produced in the process of tumor growth affect the energy metabolism of the host, so that the energy consumption of the patient is increased. The glucose has low oxidation productivity in the body with tumor diseases, the utilization of the glucose of peripheral tissues by a host is reduced, and the body tissues are resistant to insulin. Endogenous fat consumption and fat oxidation increase in tumor patients, in vivo fat stores decrease, while exogenous fat utilization is poor. The changes of protein and amino acid metabolism of tumor patients are more complex, the increase of protein decomposition exceeds the increase of synthesis, and symptoms such as hypoproteinemia, negative nitrogen balance, amino acid metabolism abnormality and the like often appear. In addition, due to the toxic and side effects of radiotherapy and chemotherapy, the intestinal absorption and immune shielding functions of patients are destroyed, and the patients show symptoms of anorexia, nausea, vomiting, diarrhea and the like. Therefore, tumor patients need reasonable nutritional support to effectively improve quality of life, reduce treatment costs and hospital stays, and obtain better clinical results.
The tumor total nutrient formula food belongs to a specific total nutrient food in formula foods with special medical purposes. The formula food for special medical application is specially processed and prepared for meeting the special requirements of people with limited food intake, digestive absorption disorder, metabolic disorder or specific disease states on nutrients or diet. A specific total nutrient formula is a formula for special medical use that can serve as a single source of nutrition to meet the nutritional needs of a target population under specific diseases or medical conditions.
Disclosure of Invention
Based on the above, the tumor total nutrient formula food which has comprehensive nutrition and can meet the special requirements of tumor patients on nutrition is needed to be provided.
A full-nutrition formula food for tumors comprises the following substances in parts by weight:
47-126 parts of nutrient medium, 0.13-0.71 part of nutrient supplement, 2.5-7.5 parts of compound mineral, 0.1-1.0 part of compound vitamin and 8.25-17 parts of Chinese medicinal extract;
the traditional Chinese medicine extract comprises at least one of the following substances in parts by weight: 0.25-0.75 part of ganoderma lucidum polysaccharide, 0.75-1.25 parts of astragalus polysaccharide, 0.25-0.75 part of tea polyphenol, 3.75-7.5 parts of dandelion extract, 0.25-0.75 part of silybum marianum extract and 3-6 parts of wild buckwheat rhizome extract.
In one embodiment, the nutritional matrix comprises the following materials in parts by weight: 15-45 parts of carbohydrate, 3-8 parts of dietary fiber, 14-28 parts of protein and 15-45 parts of fat.
In one embodiment, the carbohydrate provides 27% of the tumor total nutrient formula, the protein provides 18% of the tumor total nutrient formula, and the fat provides 54% of the tumor total nutrient formula.
In one embodiment, the carbohydrate comprises at least one of maltodextrin, xylitol, and maltose; the dietary fiber comprises at least one of fructo-oligosaccharide, resistant starch and oat fiber; the protein comprises at least one of casein, isolated whey protein, soy protein isolate and soy peptide.
In one embodiment, the protein is present in the total material of the tumor total nutritional formula in an amount of greater than 0.80g/100 kJ.
In one embodiment, the fat comprises at least one of microencapsulated medium chain fatty acid glycerides, microencapsulated olive oil, microencapsulated soybean oil, and microencapsulated fish oil.
In one embodiment, the fat comprises omega-3 fatty acids, wherein the omega-3 fatty acids comprise between 1% and 6% of the energy content of the tumor nutritionally complete formula.
In one embodiment, the nutrition enhancer comprises the following materials in parts by weight: 0.1-0.6 part of choline, 0.02-0.06 part of taurine and 0.01-0.05 part of nucleotide.
In one embodiment, the nucleotide comprises at least one of cytidine 5 ' -monophosphate, uridine 5 ' -monophosphate, adenosine 5 ' -monophosphate, disodium 5 ' -inosinate, disodium 5 ' -guanylate, disodium 5 ' -uridylate, and disodium 5 ' -cytidylate.
In one embodiment, the nucleotide is present in the total material of the tumor total nutritional formula in an amount of less than 0.7g/100 kJ.
In one embodiment, the composite mineral comprises the following minerals in parts by weight: 0.10-0.5 part of calcium, 0.05-0.4 part of phosphorus, 0.1-1.0 part of potassium, 0.2-0.6 part of sodium, 0.04-0.12 part of magnesium, 0.002-0.006 part of iron, 0.0015-0.005 part of zinc and 1 x 10 parts of magnesium-5-5×10-5Selenium, 1X 10-4-5×10-4Copper, 5X 10-4-1.2×10-3Manganese, 2X 10-5-7×10-5Iodine, 1X 10-5-5×10-5Chromium and 2X 10-5-5×10-5At least one of molybdenum.
In one embodiment, the multivitamins comprise the following vitamins in parts by weight: 2X 10-4-8×10-4Vitamin A, 4X 10-6-1×10-5Vitamin D3、5×10-3-1.5×10-2Vitamin E, 2.5X 10-5-1×10-4Vitamin K, 0.05-0.15 part of vitamin C and 5 multiplied by 10-4-1.5×10-3Vitamin B1、5×10-4-1.5×10-3Vitamin B2、5×10-4-1.5×10-3Vitamin B6、0-2×10-6Vitamin B12、1.2×10-3-3.0×10-3Nicotinic acid, 1X 10-4-5×10-4Folic acid, 1.5X 10-3-5.0×10-3Pantothenic acid and 1X 10-5-4×10-5At least one of biotin.
In one embodiment, the composition further comprises at least one of arginine, leucine and glutamine.
In one embodiment, the arginine is present in the total tumor total nutrient formula at a level greater than 0.12g/100 kJ; the content of the glutamine in the total substances of the tumor total nutrient formula food is 0.04g/100kJ-0.53g/100 kJ; the content of the leucine in the total substances of the tumor total nutrient formula food is higher than 0.03g/100 kJ.
The tumor total nutrient formula food provided by the embodiment of the invention has balanced and comprehensive nutrition by simultaneously matching the nutrient medium, the nutrient supplement, the compound mineral substance and the compound vitamin with the traditional Chinese medicine extract, and the product contains all nutrients required by tumor patients, and the mixing ratio of various nutrients is designed according to the nutrient metabolism rule of the tumor patients, thereby meeting the special requirements of the tumor patients on the nutrients. The addition of functional active ingredients of various Chinese herbal medicines can improve the concentration of functional factors, reduce the intake of various impurities, help to reduce the burden of liver and kidney and have the function of enhancing the resistance of human bodies.
The tumor total nutrient formula food provided by the embodiment of the invention not only can be used as a single nutrient source to meet the nutritional requirements of tumor patients, but also can play roles in clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and resolving masses, strengthening body resistance and consolidating constitution, enhancing immunity and preventing and treating tumors. The product can provide accurate nutritional support for tumor patients, can reverse the condition of malnutrition or cachexia of the tumor patients, improve the tolerance of the tumor patients to clinical treatment, assist the implementation of a plurality of clinical treatment means for the tumor diseases, and further prevent the related complications and death. Can help reduce the treatment cost and hospitalization time of cancer patients.
Detailed Description
In order to make the objects, technical solutions and technical effects of the present invention more apparent, specific embodiments of the present invention are described below. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The embodiment of the invention provides a tumor total nutrient formula food which comprises the following substances in parts by weight: 47-126 parts of nutrient medium, 0.13-0.71 part of nutrient supplement, 2.5-7.5 parts of compound mineral, 0.1-1.0 part of compound vitamin and 8.25-17 parts of Chinese medicinal extract. The nutrition enhancer can comprise the following substances in parts by weight: 0.1-0.6 part of choline, 0.02-0.06 part of taurine and 0.01-0.05 part of nucleotide. The traditional Chinese medicine extract can comprise at least one of the following substances in parts by weight: 0.25-0.75 part of ganoderma lucidum polysaccharide, 0.75-1.25 parts of astragalus polysaccharide, 0.25-0.75 part of tea polyphenol, 3.75-7.5 parts of dandelion or dandelion extract, 0.25-0.75 part of silybum marianum or silybum marianum extract and 3-6 parts of wild buckwheat or wild buckwheat extract.
The tumor total nutrient formula food provided by the embodiment of the invention has balanced and comprehensive nutrition by simultaneously matching the nutrient medium, the nutrient supplement, the compound mineral substance and the compound vitamin with the traditional Chinese medicine extract, and the product contains all nutrients required by tumor patients, and the mixing ratio of various nutrients is designed according to the nutrient metabolism rule of the tumor patients, thereby meeting the special requirements of the tumor patients on the nutrients. The addition of functional active ingredients of various Chinese herbal medicines can improve the concentration of functional factors, reduce the intake of various impurities, help to reduce the burden of liver and kidney and have the function of enhancing the resistance of human bodies.
The tumor total nutrient formula food provided by the embodiment of the invention not only can be used as a single nutrient source to meet the nutritional requirements of tumor patients, but also can play roles in clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and resolving masses, strengthening body resistance and consolidating constitution, enhancing immunity and preventing and treating tumors. The product can provide accurate nutritional support for tumor patients, can reverse the condition of malnutrition or cachexia of the tumor patients, improve the tolerance of the tumor patients to clinical treatment, assist the implementation of a plurality of clinical treatment means for the tumor diseases, and further prevent the related complications and death. Can help reduce the treatment cost and hospitalization time of cancer patients.
Ganoderma lucidum polysaccharide: one of the most effective components in ganoderma lucidum can improve the immunity of organisms, improve the hypoxia tolerance of the organisms, eliminate free radicals, inhibit tumors and radiation, improve the capability of synthesizing DNA, RNA and protein of livers, bone marrow and blood, prolong the service life, and ganoderma lucidum polysaccharide also has the characteristics of stimulating the nonspecific resistance of hosts, the immunological specific reaction and inhibiting the physiological activity of transplanted tumors.
Astragalus polysaccharide: one of the main active ingredients of the astragalus can be used as an immune promoter or a regulator, has the effects of resisting virus, tumor, aging, radiation, stress, oxidation and the like, can improve the immunity of the organism in the aspect of treating tumor, can reduce the toxic and side effects of other chemotherapeutics when used together with other chemosynthesizers, and simultaneously can enhance the anti-tumor effect of the chemotherapeutics.
Tea polyphenol: the main active components of green tea have moderate selective anti-tumor activity, and the action target of tea polyphenol in preventing and treating tumor is wide. The tea polyphenols have cytotoxic effect, and can induce apoptosis and differentiation of tumor cells, resist distortion, and resist cancer metastasis.
Dandelion: has antibacterial, antitumor, antioxidant, antiinflammatory, diuretic, antiallergic, antithrombotic, blood glucose reducing, blood lipid reducing, liver protecting, gallbladder function promoting, stomach invigorating, and immunity promoting effects. The dandelion can inhibit the proliferation of tumor cells, act on a tumor microenvironment and relieve the side effect of tumor drugs.
Silybum marianum: the main anti-tumor active component is the flavonolignan compound silymarin extracted from seeds, such as silybin, isosilybin, silydianin, silychristin, etc. Silymarin can exert its antitumor activity by its strong effects of blocking cell cycle and inducing tumor cell apoptosis. Silibinin can be used for resisting tumor by inducing tumor cell differentiation to normal cell.
Wild buckwheat rhizome: dried rhizome of Fagopyrum dibotrys of Polygonaceae, Wilmining clinically used for resisting tumor is effective extract of Fagopyrum dibotrys, and antitumor active ingredient of Fagopyrum dibotrys is tannin compound. The wild buckwheat rhizome can enhance the immunity of organisms, directly inhibit the growth of tumor cells, inhibit the invasion and metastasis of the tumor cells, induce the apoptosis of the tumor cells and inhibit the growth of tumor blood vessels.
Nucleotide: mainly takes part in nucleic acid, and some nucleotide analogs can interfere nucleotide metabolism and can be used as anticancer drugs.
Choline: lecithin and sphingomyelin are important constituents. The lack of choline in long-term dietary intake can cause liver, kidney, pancreas lesions, memory disorders and growth disorders, and can induce cancer, first gene damage, and then the growth and proliferation of certain variant cell lines that can form tumors. The ingestion of choline reduces the risk of cancer due to its role as a methyl group in the metabolism of one carbon unit, and population-based case-control studies have shown that high choline ingestion reduces the risk of, and mortality from, breast cancer. The choline intake is related to colorectal cancer risk, animal experiment research shows that liver cancer can be caused by choline deficiency, the choline deficiency feed for rats can cause a large amount of fat accumulation in the liver, about 70% of animals lacking choline have abnormal sensation after one year, and nearly 25% of animals have liver cancer.
Taurine: a sulfur-containing semi-essential amino acid is a conditionally essential nutrient for humans. Taurine can be used as a marker for the occurrence and early diagnosis of certain tumors, and has important significance for the prevention of tumors. Can exert the anti-tumor effect by improving the oxidation resistance of the organism, enhancing the immunity of the organism, inducing the apoptosis of tumor cells, improving the DNA damage repair capability of the organism and the like. The taurine is combined with the chemotherapy drugs, so that the curative effect of the chemotherapy drugs can be improved, and the adverse reaction of the chemotherapy drugs can be reduced. Some taurine derivatives have anti-tumor effect and can be applied to clinical treatment.
The nutrient medium may comprise the following substances in parts by weight: 15-45 parts of carbohydrate, 3-8 parts of dietary fiber, 14-28 parts of protein and 15-45 parts of fat.
Optionally, the carbohydrate may include at least one of maltodextrin, xylitol, and maltose. Maltodextrin can directly enter the stomach without being hydrolyzed by salivary amylase, and can be further digested and absorbed by small intestine mucous membrane enzyme to relieve digestion pressure. The maltodextrin is prepared from various starches as raw materials through enzymatic hydrolysis, purification and drying.
Optionally, the energy supply percentage of each substance in the nutrient medium in the tumor total nutrient formula food is as follows: 27% of carbohydrate, 18% of protein and 54% of fat. According to the formula of the invention, the tumor total nutrient formula food prepared by matching various components in a proper proportion can be dissolved in a certain amount of water to be in an isotonic state, quickly passes through the stomach to reach the small intestine, is quickly and completely absorbed, and can quickly supplement nutrition and energy required by tumor patients. Can effectively prevent and inhibit the growth, metastasis and recurrence of tumors, improve the life quality of patients, reduce the treatment cost and hospitalization time of cancer patients and obtain better clinical results.
Dietary fiber is a polysaccharide that is neither digested by digestive enzymes in the human gastrointestinal tract, nor absorbed and utilized by the human body. Can be divided into water-soluble fiber and water-insoluble fiber. The proper dietary fiber intake can help gastrointestinal peristalsis. The dietary fiber has huge adsorption groups and can bring a plurality of harmful and toxic factors out of the body. Optionally, the dietary fiber may include at least one of fructooligosaccharide, resistant starch, and oat fiber.
Alternatively, the protein may include at least one of casein, whey protein isolate, soy protein isolate, and soy peptide. The content of protein in the total material of the tumor total nutrient formula food can be higher than 0.80g/100 kJ. That is to say, the mass of protein in the tumor full-nutrition formula food is higher than 0.80g per substance mass corresponding to 100kJ of energy provided by the tumor full-nutrition formula food. Casein, lactalbumin and soybean protein all belong to high-quality protein and have wide sources.
The whey protein is protein dissolved and dispersed in whey, comprises α -whey protein, α -lactalbumin, lactoferrin, β -lactoglobulin and the like, has high nutritional value, is easy to digest and absorb, contains various active ingredients, and is helpful for regulating sleep, appetite and emotion, and is called king of protein.
The concentrated whey protein can be obtained by the operations of clarifying, ultrafiltering, drying and the like of whey, and the separated whey protein is high-purity whey protein obtained by further process treatment on the basis of the concentrated whey protein, and the purity can reach more than 90%.
The soybean protein contains nearly 20 kinds of amino acids and contains essential amino acids for human body. The nutrition is rich, the cholesterol is not contained, and the protein is one of a few varieties capable of replacing animal protein in plant protein. The soybean peptide can be a polypeptide mixture obtained by hydrolyzing or separating and refining soybean protein by an acid method or an enzyme method, mainly contains small molecular peptides, and also contains a small amount of components such as macromolecular peptides, free amino acids, saccharides, inorganic salts and the like, and has the functions of quickly recovering fatigue and enhancing muscle strength.
Optionally, the fat comprises at least one of microencapsulated medium chain fatty acid glyceride, microencapsulated olive oil, microencapsulated soybean oil, and microencapsulated fish oil. The microencapsulated fatty oil is in the form of dry, uniform and loose powder, and can be quickly dissolved into uniform emulsion without layering after being mixed with hot water. The fat oil can be prevented from being insoluble in water after microencapsulation treatment.
Medium chain fatty acid glycerides (MCT) can be produced by esterification of glycerol with fatty acids containing carbon chains of 6 to 12 carbon atoms. Typical MCTs may be saturated caprylic triglyceride or saturated capric triglyceride or saturated caprylic-capric mixed triglyceride. MCT can be a nutritional raw material and an energy source, the small intestine has higher absorption capacity than the long-chain fatty glyceride, and therefore the MCT has the advantages of fast digestion and absorption and easy energy release, can quickly supply energy to patients, and the MCT with equal quality provides twice as much energy as glucose. According to the embodiment of the invention, under the condition of meeting the fat supply of a patient, the MCT content is increased, the fat is favorably digested and absorbed by a tumor patient, and the liver burden is reduced. And because the tumor cells can not utilize fat for energy supply, the nutrition to the tumor cells can be reduced.
Olive oil is the most suitable oil for human nutrition among oils found so far. Olive oil is rich in monounsaturated fatty acids and polyunsaturated fatty acids. Polyunsaturated fatty acids include omega-3 fatty acids. Fish oil is a general term for all oily substances in fish bodies, and the main components of the fish oil are omega-3 fatty acids including DHA and EPA. Omega-3 fatty acid can inhibit cell proliferation and metastasis, inhibit intracellular signal transduction pathway, induce differentiation and apoptosis, improve constitution of tumor patients, increase survival rate of patients, and reduce tumor incidence.
The examples of the invention use a variety of oils and fats, saturated fatty acids in the product: monounsaturated fatty acids: polyunsaturated fatty acids ═ 1: 1: 1, is beneficial to the nutrition balance of human body. The energy supply percentage of omega-3 fatty acid in the tumor total nutrient formula food can be 1-6%.
Optionally, the nucleotide comprises at least one of cytidine 5 ' -monophosphate, uridine 5 ' -monophosphate, adenosine 5 ' -monophosphate, disodium 5 ' -inosinate, disodium 5 ' -guanylate, disodium 5 ' -uridylate, and disodium 5 ' -cytidylate. The content of nucleotide in total substances of the tumor total nutrient formula food is less than 0.7g/100 kJ. That is, the total nutrient formula for tumor should have a nucleotide mass of less than 0.7g per 100kJ of energy.
The complex minerals may include one or more of calcium, phosphorus, potassium, sodium, magnesium, iron, zinc, selenium, copper, manganese, iodine, chromium and molybdenum. The minerals in the composite mineral may be organic or inorganic compounds of the mineral.
Optionally, the composite mineral comprises the following minerals in parts by weight: 0.10-0.5 part of calcium, 0.05-0.4 part of phosphorus, 0.1-1.0 part of potassium, 0.2-0.6 part of sodium, 0.04-0.12 part of magnesium, 0.002-0.006 part of iron, 0.0015-0.005 part of zinc and 1 x 10 parts of magnesium-5-5×10-5Selenium, 1X 10-4-5×10-4Copper, 5X 10-4-1.2×10-3Manganese, 2X 10-5-7×10-5Iodine, 1X 10-5-5×10-5Chromium and 2X 10-5-5×10-5At least one of molybdenum.
The vitamin complex may include vitamin A, vitamin D3, vitamin E, vitamin K, vitamin C, and vitamin B1Vitamin B2Vitamin B6Vitamin B12One or more of niacin, folic acid, pantothenic acid and biotin.
Optionally, the vitamin complex comprises the following vitamins in parts by weight: 2X 10-4-8×10-4Vitamin A, 4X 10-6-1×10-5Vitamin D3、5×10-3-1.5×10-2Vitamin E, 2.5X 10-5-1×10-4Vitamin K, 0.05-0.15 part of vitamin C and 5 multiplied by 10-4-1.5×10-3Vitamin B1、5×10-4-1.5×10-3Vitamin B2、5×10-4-1.5×10-3Vitamin B6、0-2×10-6Vitamin B12、1.2×10-3-3.0×10-3Nicotinic acid, 1X 10-4-5×10-4Folic acid, 1.5X 10-3-5.0×10-3Pantothenic acid, 1X 10-5-4×10-5At least one of biotin.
Preferably, the tumor total nutrient formula further comprises at least one of arginine, leucine and glutamine. Optionally, the content of arginine in the total substances of the tumor total nutrient formula food is higher than 0.12g/100 kJ. Optionally, the content of glutamine in total substances of the tumor total nutrient formula food is 0.04g/100kJ-0.53g/100 kJ. Optionally, the content of leucine in the total substances of the tumor total nutrient formula food is higher than 0.03g/100 kJ. That is to say, in the total nutrient formula food for the tumor, the mass of arginine is higher than 0.12g, the mass of glutamic acid can be 0.04g-0.53g, and the mass of leucine is higher than 0.03g in every substance mass corresponding to 100kJ of energy provided by the formula food.
Glutamine is an essential amino acid for human body, and is the free amino acid with the highest content in human body. Under severe stress conditions such as trauma and operation, the required amount of glutamine by the organism is far greater than the production amount of endogenous glutamine, and the effect of improving the organism immunity of tumor patients and reducing the infection risk can be achieved by supplementing glutamine. Leucine and its metabolite can reduce decomposition of muscle protein and liver protein, promote protein synthesis, reduce excessive consumption of protein, and correct negative nitrogen balance. Arginine is a semi-essential or conditionally essential amino acid in mammals, and arginine supplementation can play a role in enhancing the immune function of patients and reducing the incidence of postoperative infection.
The embodiment of the invention also provides a preparation method of the powder type tumor total nutrient formula food, which comprises the following steps:
s110, weighing traditional Chinese medicine extracts, carbohydrates, proteins, fat, dietary fibers, nucleotides, taurine and choline according to a ratio, crushing, sieving with a 80-mesh sieve, uniformly mixing, and uniformly mixing with a mineral premix and a vitamin premix to obtain a mixed material;
s120, dissolving, drying and granulating the mixed material; and
and S130, quantitatively packaging a product obtained by granulating the mixed material to obtain the powder type tumor total-nutrient formula food.
The invention also provides a preparation method of the emulsion type tumor total nutrient formula food, which comprises the following steps:
s210, weighing traditional Chinese medicine extracts, carbohydrates, proteins, fat, dietary fibers, nucleotides, taurine and choline according to a ratio, crushing, sieving with a 80-mesh sieve, uniformly mixing, and uniformly mixing with a mineral premix and a vitamin premix to obtain a mixed material;
s220, dissolving the mixed materials, and adding an emulsifier to fix the volume to obtain an emulsion product;
s230, placing the emulsion product into a colloid mill for 10min, and homogenizing and degassing at high pressure to obtain a feed liquid; and
s240, heating, canning and sterilizing the obtained feed liquid, and packaging to obtain the emulsion type tumor total nutrient formula food.
Preferably, the preparation of the dandelion extract may comprise the following steps:
s10, adding water into the dandelion for microwave extraction;
s20, concentrating the extract under reduced pressure to obtain extract with specific gravity of 1.1-1.15; and
and S30, spray drying to obtain extract powder.
The preparation method of herba Silybi Mariani or rhizoma Fagopyri Dibotryis extract can be the same as that of herba Taraxaci extract.
Example 1 Total nutrient formula food for tumors
The components and contents are as follows:
a nutrient medium: 30.00g of maltodextrin, 3.00g of sodium caseinate, 8.00g of isolated whey protein, 9.00g of soybean protein isolate, 1.00g of soybean peptide, 5.00g of soybean oil, 19.00g of fish oil, 1.00g of medium-chain fatty glyceride, 5.00g of olive oil, 2.00g of fructo-oligosaccharide, 1.00g of resistant starch and 2.00g of oat fiber;
a nutrition enhancer: 0.40g of choline, 0.04g of taurine and 0.02g of nucleotide;
compound mineral substance: 4.363g of compound macromineral and 0.436g of compound trace mineral;
compounding vitamins: 0.436 g;
traditional Chinese medicine extract: 0.5g of ganoderma lucidum polysaccharide, 1.0g of astragalus polysaccharide, 0.5g of tea polyphenol, 0.5g of silybum marianum extract, 5.0g of dandelion extract and 4.0g of wild buckwheat rhizome extract;
amino acids: 3.00g of arginine, 1.00g of leucine and 5.00g of glutamine;
wherein,
0.436g of compound vitamin is a mixture of 0.250mg of vitamin A, 0.005mg of vitamin D3, 7.000mg of vitamin E, 0.028mg of vitamin K, 79.200mg of vitamin C, 0.616mg of vitamin B1, 0.616mg of vitamin B2, 0.616mg of vitamin B6, 0.001mg of vitamin B12, 1.760mg of nicotinic acid, 0.114mg of folic acid, 2.552mg of pantothenic acid, 0.019mg of biotin and auxiliary materials.
4.363g of compound macro mineral substance is a mixture of 284mg of calcium, 223mg of phosphorus, 568mg of potassium, 422mg of sodium, 98mg of magnesium and auxiliary materials thereof.
0.436g of the compound trace mineral is a mixture of 4.4mg of iron, 3.3mg of zinc, 0.022mg of selenium, 0.308mg of copper, 0.88mg of manganese, 0.044mg of iodine, 0.022mg of chromium, 0.035mg of molybdenum and auxiliary materials.
Extraction: extracting herba Taraxaci, herba Silybi Mariani, and rhizoma Fagopyri Dibotryis with water under microwave, concentrating the extractive solution under reduced pressure to obtain extract with specific gravity of 1.1-1.15, and spray drying to obtain extract powder;
mixing materials: mixing the weighed extract powders of herba Taraxaci, herba Silybi Mariani and rhizoma Fagopyri Dibotryis, Ganoderma polysaccharides, radix astragali polysaccharides, tea polyphenols, carbohydrates, proteins, fats, dietary fiber, choline, nucleotides, taurine, amino acids, etc., and mixing with mineral premix and vitamin premix to obtain mixed material;
and (3) granulation: dissolving, drying and granulating the mixed materials;
and (4) quantitative subpackaging: and (5) quantitatively subpackaging the granulated substances in 500 g/pot.
Example 2 Total nutrient formula food for tumors
The components are as follows: the difference from example 1 is that 0.26g of xanthan gum, 1.09g of mono-and di-glyceride fatty acid and 0.87g of phospholipid are also added.
Preparing materials: mixing maltodextrin, microencapsulated soybean oil, microencapsulated fish oil, microencapsulated medium-chain fatty acid glyceride, microencapsulated olive oil, sodium caseinate, isolated whey protein, isolated soybean protein, soybean peptide, xanthan gum, mono-diglycerol fatty acid ester, phospholipid, Chinese medicinal extract, choline, nucleotide, taurine, vitamins, minerals, amino acids, etc. to obtain a mixture
Dissolving and fixing volume: and dissolving the mixed material in water, and fixing the volume to a proper volume to obtain the feed liquid.
Homogenizing: pouring the feed liquid into a colloid mill cleaned circularly for 10min, discharging the feed liquid, homogenizing under high pressure, and degassing;
filling and sterilizing: heating the homogenized materials, canning, sterilizing, and sealing.
Comparative example 1 Total nutrient formula food for tumor containing no herbal extract
The difference from the example 1 is that the traditional Chinese medicine extract component is not contained.
Comparative example 2 conventional feed
The conventional feed is a commercial product.
Experimental example 1 study of tumor total nutrient formula food on SPF mouse animal test
Purpose of the experiment: effect of tumor total nutrient formula on body weight, tumor mass weight, spleen index and thymus index of pathogen free (SPF) mice.
Test materials: the tumor total nutrient formula food of example 1, the tumor total nutrient formula food of comparative example 1 without the traditional Chinese medicine extract, and the conventional feed of comparative example 2.
Test animals: SPF mice, weighing 18-22g, half male and half female.
The test environmental conditions are as follows: the temperature is 22-23 ℃, and the humidity is 52-58%.
The test method comprises the following steps: extracting S180 tumor liquid and normal saline under the aseptic condition according to the ratio of 1: 3, diluting to obtain a tumor liquid diluent; injecting 0.2ml tumor diluent under the right axilla of mice under aseptic condition, weighing the mice 24 hours later, and randomly dividing into 3 groups, namely a tumor-bearing control group, an experimental group and a Chinese medicine-removed control group, wherein each group contains 12 animals. Wherein the tumor-bearing control group is fed with the conventional feed in the comparative example 2, the experimental group is fed with the tumor total nutrient formula prepared in the example 1, and the Chinese medicinal herb-removed control group is fed with the tumor total nutrient formula without the Chinese medicinal herb extract in the comparative example 1.
Another 12 normal SPF mice of appropriate weight, half each of the males and females, were inoculated with an equal amount of physiological saline as a sham-inoculated group, and fed with the conventional feed of comparative example 2 daily, as a normal control group.
Feeding on the same day, freely drinking water, keeping the laboratory temperature at 22-23 deg.C and relative humidity at 52-58%, keeping good illumination and ventilation conditions, recording the activity of mouse at fixed time every day, and continuously feeding for 14 days. The following day after the last administration, mice were sacrificed, the body weights of the mice were accurately weighed using an electronic balance, subcutaneous tumor masses, spleens, and thymus were peeled off and weighed, and spleen and thymus indices were calculated. Experimental results t-test between groups was performed. Spleen index is spleen mass (mg)/body weight (g), and thymus index is thymus mass (mg)/body weight (g).
And (3) test results:
1) influence of tumor total nutrient formula food on body weight and tumor mass of SPF (specific pathogen free) mice
Referring to Table 1, it can be seen that the difference in body weight was not statistically significant (P > 0.05) before mice were placed in each group. After 14 days, the body weight of each group of mice was significantly increased (P < 0.05) compared to before the start of feeding. After the experiment is finished, compared with a normal control group, the mouse of the tumor-bearing control group, the experiment group and the Chinese medicine-removed control group has low weight growth speed, has no statistical significance (P is more than 0.05) in change, and may influence the growth and development of the mouse by the tumor-bearing state, the medicine and injection stimulation. Compared with the tumor-bearing control group and the Chinese medicine-removed control group, the weight of the mice in the experimental group is increased rapidly, and the change has statistical significance (P is less than 0.05). The average tumor weight of the experimental group is lower than that of the traditional Chinese medicine-removed control group and the tumor-loaded control group, but the difference is not statistically significant (P is more than 0.05). The tumor total nutrient formula food provided by the embodiment of the invention can effectively inhibit the growth of tumors, provide more comprehensive nutrient substances for mice and reduce the phenomenon that the weight of the mice is reduced due to the influence of the tumors.
Table 1 effect of tumor total nutrient formula on body weight (g) of SPF mice (n ═ 12, x ± s)
Time of weighing Initial body weight (g) Ending body weight (g) Tumor mass weight (g)
Normal control group 20.28±1.3 25.28±2.1 --
Tumor-bearing control group 19.35±1.2 24.22±1.8 1.83±0.25
Experimental group 19.42±1.3 24.86±1.9 1.75±0.30
Control group without traditional Chinese medicine 19.31±1.2 24.72±1.7 1.78±0.31
2) Influence of tumor total nutrient formula food on spleen index and thymus index of SPF (specific pathogen free) mice
The thymus is a central immune organ of an immune system, can maintain the normal immune balance of an organism, is a main endocrine gland for regulating and controlling the immune system, has the functions of establishing self tolerance, immune regulation, barrier antigen and the like, is a place for lymphocyte differentiation, development and maturation, is also involved in regulating peripheral mature cells, and avoids the occurrence of diseases such as autoimmune diseases, inflammation, tissue hyperplasia, thymoma and the like. The spleen is the largest peripheral immune organ in vivo, plays an important role in body immunity, particularly in the aspect of anti-tumor immunity, is rich in a large number of immune cells and immune factors which participate in tumor immunity, such as lymphocytes, macrophages, cells, opsonin, complement and the like, and can be used as one of immune function indexes. Thymus index and spleen index are important parameters that directly reflect the immune status of the body. Participate in immune reaction through different mechanisms to play the immune function.
TABLE 2 Effect of tumor Total Nutrition formula on spleen index and thymus index (n 12, x + -s) in SPF mice
Spleen index Index of thymus
Normal control group 8.87±0.76 3.92±0.31
Tumor-bearing control group 6.08±0.64 2.31±0.23
Experimental group 8.52±0.91 4.03±0.37
Control group without traditional Chinese medicine 6.41±0.84 2.50±0.35
Referring to Table 2, spleen index was significantly decreased (P < 0.05) in the tumor-bearing control group mice compared to the normal control group; compared with a tumor-bearing control group and a Chinese medicine-removed control group, the spleen index of the experimental group is increased, wherein the difference of the spleen index increase of the experimental group has statistical significance (P is less than 0.05).
Compared with a normal control group, the thymus index of the tumor-bearing control group mice is obviously reduced (P is less than 0.05); compared with a tumor-bearing control group and a Chinese medicine-removed control group, the thymus index of the experimental group is increased, wherein the difference of the increase of the thymus index of the experimental group has statistical significance (P is less than 0.05).
The experimental result shows that the tumor specific total nutrient formula food provided by the embodiment of the invention can obviously improve the thymus index and the spleen index of a mouse, can effectively improve the immunocompetence of the mouse, improves the immune condition of an organism and enhances the anti-infection ability. Can be used for improving the disease resistance of tumor patients and improving the survival quality of tumor patients.
Experimental example 2 determination of phagocytic neutral red function of macrophage in abdominal cavity of SPF mouse by tumor total nutrient formula food
Purpose of the experiment: the effect of the tumor total nutrient formula food on the phagocytic function of neutral red by macrophages in the abdominal cavity of an SPF mouse.
Test materials: the tumor total nutrient formula food of example 1, the tumor total nutrient formula food of comparative example 1 without the traditional Chinese medicine extract, and the conventional feed of comparative example 2.
Test animals: SPF mice, weighing 18-22g, half male and half female.
The test environmental conditions are as follows: the temperature is 22-23 ℃, and the humidity is 52-58%.
The test method comprises the following steps: the pretreatment method was the same as in experimental example 1, except that in experimental example 1: on the 14 th day of administration of each group of mice, 6% sterile starch broth was injected into the abdominal cavity of each mouse, after 1 hour, the mice were sacrificed by collecting blood from orbital venous plexus, then immersed in ethanol in an ultra-clean bench for 3min, lying on the back, and then 2ml 1640 culture solution was injected into the abdominal cavity, the abdominal part was gently kneaded for 3min, the abdominal cavity was opened, abdominal cavity solution was collected and centrifuged and washed, 1ml of complete 1640 culture solution was aspirated to resuspend the cells, the cell concentration was adjusted, 0.1ml of cell suspension was added to the culture plate for culture, incubated in a 37 ℃, 5% CO2 incubator for 2h, the culture solution was removed, 0.1ml of neutral red solution was added to each well, the culture was continued for 3h, the cells were washed with serum-free 1640 culture solution 3 times, cell lysate was added to each well, the lysate was left in a refrigerator at 4 ℃ overnight, and the absorbance (OD) value was measured with a microplate reader at 570 nm. Experimental results t-test between groups was performed.
Macrophages can modulate both nonspecific and specific immune responses and are important target cells for immunologically active polysaccharides. The experimental group formula contains components such as polysaccharide and tea polyphenol, and the polysaccharide can directly activate macrophages and enhance the phagocytic activity of the macrophages, so that the immunity is improved. Macrophages are the most important phagocytic cells in the immune system, and the strength of phagocytic activity is an important index reflecting the function of the macrophages. The result shows that the absorbance values of the experimental group are obviously superior to those of the control group and the Chinese medicine-removed control group, the phagocytic activity of macrophages is enhanced, and the experimental group is added with ganoderma lucidum polysaccharide, astragalus polysaccharide and other substances, so that the immunity of patients can be enhanced to a certain extent, and the disease resistance of the experimental group is improved.
TABLE 3 Effect of the tumor nutritionally complete formula on the ability of macrophages in mouse abdominal cavity to phagocytose neutral red (n ═ 12, x. + -. s)
Group of Phagocytic neutral red (OD570nm)
Normal control group 0.94±0.11
Tumor-bearing control group 0.72±0.09
Experimental group 1.43±0.15
Removing traditional Chinese medicineControl group 0.85±0.15
Referring to Table 3, the absorbance values of the tumor-bearing control group were significantly decreased (P < 0.05) compared to the normal control group; compared with the tumor-bearing control group, the experimental group can obviously improve the phagocytic neutral red function of macrophages in the abdominal cavity of the mouse (P is less than 0.05). The absorbance value of the control group without traditional Chinese medicine is higher than that of the control group with tumor, but has no statistical significance. Experimental results show that the tumor total nutrient formula food provided by the embodiment of the invention can effectively improve the immune function of mice. Can be used for improving the disease resistance of tumor patients and improving the survival quality of tumor patients.
Experimental example 3 research on SD rat animal test by tumor total nutrient formula food
Purpose of the experiment: the influence of the tumor total nutrient formula food on the conventional blood and serum biochemical indexes of SD rats.
Test materials: the tumor total nutrient formula food of example 1, the tumor total nutrient formula food of comparative example 1 without the traditional Chinese medicine extract, and the conventional feed of comparative example 2.
Test animals: SD rats, 48, weighing 18-22g, male and female halves.
The test environmental conditions are as follows: the temperature is 22-23 ℃, and the humidity is 52-58%.
The test method comprises the following steps: SD rats are adaptively fed for 3 days and then weighed, and are randomly divided into 3 groups according to the sex weights, namely a normal control group, an experimental group and a Chinese medicine-removed control group, wherein each group comprises 16 animals and half of animals. Wherein the normal control group is fed with the conventional feed of comparative example 2, the experimental group is fed with the tumor total nutrient formula prepared in example 1, and the Chinese medicinal herb-removed control group is fed with the tumor total nutrient formula without the Chinese medicinal herb extract of comparative example 1. Animals were weighed for 2 weeks on a weekly basis at fixed times. At the end of the experiment, the animals were anesthetized, 2 blood portions were taken from the abdominal aorta, one portion was used for routine examination of blood, the other portion was centrifuged, and serum was taken for examination of biochemical indices.
And (3) test results:
1) influence of tumor total nutrient formula food on weight of SD rat
Referring to table 4, compared to the normal control group, the body weight of the experimental group and the rats fed with the traditional Chinese medicine-removed control group was reduced after 2 weeks, but there was no statistical difference, probably due to the influence of the animal on the adaptation process such as the taste of new food.
Table 4 effect of tumor total nutrient formula on body weight (g) of SD rats (n ═ 16, x ± s)
Time of weighing Starting time Day 7 Day 14
Normal control group 208.46±14.03 221.81±30.38 243.46±39.10
Experimental group 207.89±12.78 218.66±31.91 239.94±31.63
Control group without traditional Chinese medicine 207.54±13.01 216.57±30.28 236.72±31.17
2) Influence of tumor total nutrient formula food on SD rat serum biochemical indexes
Table 5 biochemical statistics of SD rat serum for tumor complete nutrition formula (n ═ 16, x ± s)
Name of item Control group Experimental group Control group without traditional Chinese medicine
Glutamic-pyruvic transaminase 95.81±33.50 99.14±26.08 97.26±24.67
Glutamic-oxalacetic transaminase 207.93±82.92 167.66±53.20 181.53±50.37
Urea nitrogen 8.00±1.45 8.03±1.18 8.08±1.09
Creatinine 26.15±4.58 21.66±1.94 23.52±2.21
Total Cholesterol 1.52±0.24 1.39±0.32 1.45±0.37
Triglycerides 0.82±0.29 0.90±0.39 0.87±0.41
High density lipoprotein cholesterol 0.58±0.10 0.72±0.19 0.75±0.18
Referring to table 5, the tumor total nutrient formula food replaces the feed, and the biochemical indexes of the serum of the SD rat are not significantly changed after the SD rat is raised for two weeks.
3) Influence of tumor total nutrient formula food on blood routine of SD rat
Table 6 general statistical results of tumor total nutrient formula food on SD rat blood (n ═ 16, x ± s)
Name of item Normal control group Experimental group Control group without traditional Chinese medicine
White blood cell 16.21±8.07 20.24±11.22 19.02±10.87
Neutrophils 2.15±0.91 2.33±1.23 2.27±1.05
Lymphocytes 11.62±5.07 12.11±7.03 11.87±6.96
Monocyte cell 1.03±0.80 0.94±0.77 0.92±0.74
Eosinophils 0.10±0.07 0.08±0.06 0.08±0.05
Basophilic granulocytes 0.03±0.02 0.07±0.09 0.06±0.08
Neutrophil ratio 15.25±4.18 16.35±6.95 16.08±6.67
Lymphocyte ratio 78.43±5.58 77.97±8.65 77.85±8.71
Monocyte fraction 5.70±2.78 5.24±2.34 5.36±2.30
Eosinophil ratio 0.73±0.46 0.39±0.17 0.51±0.23
Basophil ratio 0.25±0.14 0.25±0.16 0.24±0.15
Red blood cell 6.60±0.44 6.89±0.77 6.77±0.75
Hemoglobin 123.69±7.17 130.27±16.40 125.77±16.18
Hematocrit of red blood cells 38.29±2.19 40.79±4.46 39.37±3.28
Mean volume of red blood cells 57.95±2.60 59.29±2.26 59.03±2.48
Mean hemoglobin content 18.65±0.64 18.89±0.57 18.74±0.61
Mean hemoglobin concentration 302.20±13.48 318.87±10.77 311.55±16.85
Width of distribution of red blood cells 15.79±1.55 17.31±2.15 16.28±2.02
Blood platelet 1136.25±193.17 1003.53±330.36 1097.36±270.54
Platelet aggregation 0.86±0.17 0.78±0.24 0.82±0.27
Breadth of platelet distribution 7.88±0.61 8.86±1.06 8.27±0.96
Mean platelet volume 7.41±0.64 7.87±0.56 7.71±0.54
Referring to table 6, the experimental results show that the tumor total nutrient formula food replaces the feed, and the conventional blood indexes of the SD rat are not significantly changed after the SD rat is fed for two weeks.
The tumor specific total nutrient formula food provided by the embodiment of the invention is matched with the traditional Chinese medicine for strengthening the body resistance and consolidating the constitution on the basis of meeting the nutrient components of normal fat, protein, vitamins, trace elements and the like of a human body, has no obvious influence on the vital signs of normal animals, has no obvious change on blood routine and serum biochemical indexes, and is safe to eat.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (14)

1. A full-nutrition formula food for tumors comprises the following substances in parts by weight:
47-126 parts of nutrient medium, 0.13-0.71 part of nutrient supplement, 2.5-7.5 parts of compound mineral, 0.1-1.0 part of compound vitamin and 8.25-17 parts of Chinese medicinal extract;
the traditional Chinese medicine extract comprises at least one of the following substances in parts by weight: 0.25-0.75 part of ganoderma lucidum polysaccharide, 0.75-1.25 parts of astragalus polysaccharide, 0.25-0.75 part of tea polyphenol, 3.75-7.5 parts of dandelion extract, 0.25-0.75 part of silybum marianum extract and 3-6 parts of wild buckwheat rhizome extract.
2. The tumor total nutrient formula food according to claim 1, wherein the nutrient medium comprises the following substances in parts by weight: 15-45 parts of carbohydrate, 3-8 parts of dietary fiber, 14-28 parts of protein and 15-45 parts of fat.
3. The tumor nutritionally complete formula according to claim 2, wherein the carbohydrate provides 27% of the energy provided by the tumor nutritionally complete formula, the protein provides 18% of the energy provided by the tumor nutritionally complete formula and the fat provides 54% of the energy provided by the tumor nutritionally complete formula.
4. The tumor total nutrient formula food according to claim 2,
the carbohydrate comprises at least one of maltodextrin, xylitol and maltose;
the dietary fiber comprises at least one of fructo-oligosaccharide, resistant starch and oat fiber;
the protein comprises at least one of casein, isolated whey protein, soy protein isolate and soy peptide.
5. The tumor nutritionally complete formula according to claim 2, wherein the protein is present in an amount higher than 0.80g/100kJ of the total material of the tumor nutritionally complete formula.
6. The tumor nutritionally complete formula according to claim 2, wherein the fat comprises at least one of microencapsulated medium chain fatty acid glycerides, microencapsulated olive oil, microencapsulated soybean oil and microencapsulated fish oil.
7. The tumor nutritionally complete formula according to claim 2, wherein said fat contains omega-3 fatty acids, said omega-3 fatty acids comprising between 1% and 6% of the energy supply of said tumor nutritionally complete formula.
8. The tumor total nutrient formula food as claimed in claim 1, wherein the nutrient supplement comprises the following materials in parts by weight: 0.1-0.6 part of choline, 0.02-0.06 part of taurine and 0.01-0.05 part of nucleotide.
9. The tumor nutritionally complete formula according to claim 8, wherein the nucleotides comprise at least one of cytidine 5 ' -monophosphate, uridine 5 ' -monophosphate, adenosine 5 ' -monophosphate, disodium 5 ' -inosinate, disodium 5 ' -guanylate, disodium 5 ' -uridylate and disodium 5 ' -cytidylate.
10. The tumor nutritionally complete formula according to claim 8, wherein the nucleotide content in the total material of the tumor nutritionally complete formula is less than 0.7g/100 kJ.
11. The tumor total nutrient formula food according to claim 1, wherein the compound minerals comprise the following minerals in parts by weight: 0.10-0.5 part of calcium, 0.05-0.4 part of phosphorus, 0.1-1.0 part of potassium, 0.2-0.6 part of sodium, 0.04-0.12 part of magnesium, 0.002-0.006 part of iron, 0.0015-0.005 part of zinc and 1 x 10 parts of magnesium-5-5×10-5Selenium, 1X 10-4-5×10-4Copper, 5X 10-4-1.2×10-3Manganese, 2X 10-5-7×10-5Iodine, 1X 10-5-5×10-5Chromium and 2X 10-5-5×10-5At least one of molybdenum.
12. The tumor total nutrient formula food as claimed in claim 1, wherein the vitamin complex comprises the following vitamins in parts by weight: 2X 10-4-8×10-4Vitamin A, 4X 10-6-1×10-5Vitamin D3、5×10-3-1.5×10-2Vitamin E, 2.5X 10-5-1×10-4Vitamin K, 0.05-0.15 part of vitamin C and 5 multiplied by 10-4-1.5×10-3Vitamin B1、5×10-4-1.5×10-3Vitamin B2、5×10-4-1.5×10-3Vitamin B6、0-2×10-6Vitamin B12、1.2×10-3-3.0×10-3Nicotinic acid, 1X 10-4-5×10-4Folic acid, 1.5X 10-3-5.0×10-3Pantothenic acid and 1X 10-5-4×10-5At least one of biotin.
13. The tumor total nutrient formula food according to claim 1, further comprising at least one of arginine, leucine, and glutamine.
14. The tumor nutritionally complete formula according to claim 13, wherein the arginine is present in an amount higher than 0.12g/100kJ of the total material of the tumor nutritionally complete formula; the content of the glutamine in the total substances of the tumor total nutrient formula food is 0.04g/100kJ-0.53g/100 kJ; the content of the leucine in the total substances of the tumor total nutrient formula food is higher than 0.03g/100 kJ.
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CN108771220A (en) * 2018-06-11 2018-11-09 山东中医药大学 A kind of full nutrition companion's meal powder of tumor patient
CN109602013A (en) * 2018-08-07 2019-04-12 丽睿客信息科技（北京）有限公司 Function of blood sugar reduction food
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CN111220604A (en) * 2019-12-06 2020-06-02 东北农业大学 Method for measuring total starch content in meat product
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CN108771220A (en) * 2018-06-11 2018-11-09 山东中医药大学 A kind of full nutrition companion's meal powder of tumor patient
CN109602013A (en) * 2018-08-07 2019-04-12 丽睿客信息科技（北京）有限公司 Function of blood sugar reduction food
CN109805389A (en) * 2019-02-26 2019-05-28 青岛大学附属医院 A kind of tumour tailored version clinical nutrition formula and preparation method thereof
CN111220604A (en) * 2019-12-06 2020-06-02 东北农业大学 Method for measuring total starch content in meat product
CN111220604B (en) * 2019-12-06 2022-03-15 东北农业大学 Method for measuring total starch content in meat product
CN114794460A (en) * 2022-05-10 2022-07-29 华中农业大学 Immunity-enhanced full-nutrition formula food with special medical application

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