CN107981339A - Tumour full nutrition formula food - Google Patents
Tumour full nutrition formula food Download PDFInfo
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- CN107981339A CN107981339A CN201711287325.2A CN201711287325A CN107981339A CN 107981339 A CN107981339 A CN 107981339A CN 201711287325 A CN201711287325 A CN 201711287325A CN 107981339 A CN107981339 A CN 107981339A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The present invention provides a kind of tumour full nutrition formula food, includes the material of following parts by weight：8.25 17 parts of 47 126 parts of nutrient matrix, 0.13 0.71 parts of nutrition fortifier, 2.5 7.5 parts of composite mineral matter, 0.1 1.0 parts of multi-vitamins and Chinese medical extract；The Chinese medical extract includes at least one of material of following parts by weight：36 parts of 0.25 0.75 parts of ganoderma lucidum polysaccharide, 0.75 1.25 parts of astragalus polyose, 0.25 0.75 parts of tea polyphenols, 3.75 7.5 parts of dandelion extract, 0.25 0.75 parts of milk thistle extract and Rhizoma Fagopyri Dibotryis extract.
Description
Technical field
The present invention relates to special medicine purposes formula food field, more particularly to tumour full nutrition formula food.
Background technology
Tumour is body under the effect of various carcinogenic factors, and some cell of local organization loses pair at the genetic level
The normal regulation of its growth, the abnormality for causing its clonal abnormality hyperplasia and being formed.Due to the consumption of tumour, own metabolism
The factor such as influence and mental depression to appetite of disorder, tumour, tumor patient is with the nutrition characterized by weight loss
Bad incidence is at a relatively high.Chinese Anti-Cancer Association's tumors of nutrients investigates 15112 malignant tumours with supportive treatment Professional Committee
Patient, the results show malignant tumor patient malnutrition incidence are up to 67%.And malnutrition will significantly raise tumour simultaneously
Disease and the death rate are sent out, extends the hospital stays, increases hospitalization cost.
The metabolism of tumor patient and common normal person are different, and the energy expenditure of tumour patient can increase compared with normal person
Add.The reason for energy expenditure increase, there is two：When tumour divide rapidly in cell in itself, needed in Tumor Growth it is a large amount of
Energy；Second, some materials produced in Tumor Growth influence the energetic supersession of host, make the increase of patient's energy expenditure.
Glucose is low in tumour patient vivo oxidation production capacity rate, and host is to periphery tissue glucose using declining, and body tissue is to pancreas
Island element tolerance.Endogenous fat consumption and the fat oxidation increase of tumor patient, body fat deposit is reduced, and ectogenous fat
Utilize difference.The change of the protein and amino acid metabolism of tumour patient is increasingly complex, and body protein decomposes and increases above synthesis
Increase, often there are the symptoms such as Hypoproteinemia, negative nitrogen balance and Aminoacidopathy.Make additionally due to the poison of chemicotherapy is secondary
With the intestinal absorption and immune function of shielding, patient for destroying patient show the symptoms such as apocleisis, nausea,vomiting,diarrhea.Cause
This tumor patient need rational nutritional support so as to quality of effectively making the life better, reduce medical expense and in hospital when
Between, obtain more preferable clinical effectiveness.
Tumour full nutrition formula food belongs to the specific wholefood class in special medicine purposes formula food.Special doctor
It is to meet limited feed, Disorder of Digestion and A orption, metabolic disorder or particular disease states crowd to battalion to learn purposes formula food
The special requirement of element or meals is supported, specially processes the formula food being formulated.Specific full nutritional formulas is can be used as list
One source of nutrition meets the special medicine purposes formula food of target group's nutritional need under specified disease or medical condition.
The content of the invention
Based on this, it is necessary to provide that a kind of nutrition is comprehensive, disclosure satisfy that the tumour of specific demand of the tumor patient to nutrition
Full nutrition formula food.
A kind of tumour full nutrition formula food, includes the material of following parts by weight：
47-126 parts of nutrient matrix, 0.13-0.71 parts of nutrition fortifier, 2.5-7.5 parts of composite mineral matter, multi-vitamins
0.1-1.0 parts and 8.25-17 parts of Chinese medical extract；
The Chinese medical extract includes at least one of material of following parts by weight：0.25-0.75 parts of ganoderma lucidum polysaccharide, Huang
0.75-1.25 parts of astragalus polysaccharides, 0.25-0.75 parts of tea polyphenols, 3.75-7.5 parts of dandelion extract, milk thistle extract 0.25-
0.75 part and 3-6 parts of Rhizoma Fagopyri Dibotryis extract.
In one of the embodiments, the nutrient matrix includes the material of following parts by weight：Carbohydrate 15-45
Part, 3-8 parts of dietary fiber, 14-28 parts of protein and 15-45 parts of fat.
In one of the embodiments, the carbohydrate accounts for the energy supply percentage of the tumour full nutrition formula food
For 27%, the energy supply percentage that the protein accounts for the tumour full nutrition formula food is 18%, and the fat accounts for described swollen
The energy supply percentage of knurl full nutrition formula food is 54%.
In one of the embodiments, the carbohydrate is included in maltodextrin, xylitol and maltose at least
It is a kind of；The dietary fiber includes at least one of oligofructose, resistant starch and common oats fibre；The protein includes
At least one of casein, sepg whey albumen, soybean separation protein bletilla soybean peptide.
In one of the embodiments, content of the protein in the tumour full nutrition formula food total material is high
In 0.80g/100kJ.
In one of the embodiments, the fat includes microencapsulation medium-chain fatty glyceride, microencapsulation olive oil, micro-
At least one of encapsulated soybean oil and microencapsulation fish oil.
In one of the embodiments, omega-fatty acid is contained in the fat, the omega-fatty acid accounts for the tumour
The energy supply percentage of full nutrition formula food is 1%-6%.
In one of the embodiments, the nutrition fortifier includes the material of following parts by weight：0.1-0.6 parts of choline,
0.01-0.05 parts of 0.02-0.06 parts of taurine and nucleotide.
In one of the embodiments, the nucleotide includes 5'-CMP, 5 '-uridine monophosphate, 5 '-mono- phosphorus
At least one of adenosine monophosphate, 5'-inosinic acid disodium, 5'-GMP2Na, 5'-UMP disodium and 5'-CMP disodium.
In one of the embodiments, content of the nucleotide in the tumour full nutrition formula food total material is low
In 0.7g/100kJ.
In one of the embodiments, the composite mineral matter includes the mineral matter of following parts by weight：0.10-0.5 parts of calcium,
0.05-0.4 parts of phosphorus, 0.1-1.0 parts of potassium, 0.2-0.6 parts of sodium, 0.04-0.12 parts of magnesium, 0.002-0.006 parts of iron, 0.0015-
0.005 part of zinc, 1 × 10-5-5×10-5Part selenium, 1 × 10-4-5×10-4Part copper, 5 × 10-4-1.2×10-3Part manganese, 2 × 10-5-7
×10-5Part iodine, 1 × 10-5-5×10-5Part chromium and 2 × 10-5-5×10-5At least one of part molybdenum.
In one of the embodiments, the multi-vitamins include the vitamin of following parts by weight：2×10-4-8×10-4Part vitamin A, 4 × 10-6-1×10-5The raw D of part dimension3、5×10-3-1.5×10-2Part vitamin E, 2.5 × 10-5-1×10-4Part
Vitamin K, 0.05-0.15 part vitamin C, 5 × 10-4-1.5×10-3Part vitamin B1、5×10-4-1.5×10-3Part vitamin
B2、5×10-4-1.5×10-3Part vitamin B6、0-2×10-6Part vitamin B12、1.2×10-3-3.0×10-3Part nicotinic acid, 1 ×
10-4-5×10-4Part folic acid, 1.5 × 10-3-5.0×10-3Part pantothenic acid and 1 × 10-5-4×10-5At least one in part biotin
Kind.
In one of the embodiments, at least one of arginine, leucine, glutamine are further included.
In one of the embodiments, content of the arginine in the tumour full nutrition formula food total material is high
In 0.12g/100kJ；Content of the glutamine in the tumour full nutrition formula food total material is 0.04g/
100kJ-0.53g/100kJ；Content of the leucine in the tumour full nutrition formula food total material is higher than 0.03g/
100kJ。
Tumour full nutrition formula food provided in an embodiment of the present invention, passes through nutrient matrix, nutrition fortifier, complex mineral
Matter, multi-vitamins coordinate Chinese medical extract at the same time, and nutrition is balanced and comprehensive, and the whole of tumor patient needs is contained in product
Nutrient, and various nutrient charge ratios are designed according to the Nutrition and Metabolism rule of tumor patient, meet tumor patient
To the particular/special requirement of nutrient.The addition of a variety of Chinese herbal medicine functional active components, can improve the concentration of function factor, reduce each
The intake of kind impurity, helps to mitigate liver kidney burden, has the function that to strengthen resistance of human body.
Tumour full nutrition formula food provided in an embodiment of the present invention can be used as single source of nutrition and meet that tumour is suffered from
The nutritional need of person, can also play clearing heat and detoxicating, promoting blood circulation, dispersing swelling and dissipating binds, strengthen the body resistance to consolidate the constitution, strengthen immunity and prevention it is swollen
The effect of knurl.This product can provide accurately nutritional support for tumor patient, can reach reversing tumor patient it is malnutritive or
Cachectic situation, improves tolerance of the tumor patient to clinical treatment, assists to the clinical many treatment means of tumor disease
Implement, and then prevent associated complication and death.Can aid in reduce cancer patient medical expense and in hospital when
Between.
Embodiment
In order to which the purpose of the present invention, technical solution and technique effect is more clearly understood, below to the specific of the present invention
Embodiment is described.It should be appreciated that specific embodiment described herein is not used to limit this only to explain the present invention
Invention.
The embodiment of the present invention provides a kind of tumour full nutrition formula food, includes the material of following parts by weight：Nutrient matrix
47-126 parts, 0.13-0.71 parts of nutrition fortifier, 2.5-7.5 parts of composite mineral matter, 0.1-1.0 parts of multi-vitamins and Chinese medicine
8.25-17 parts of extract.Nutrition fortifier can include the material of following parts by weight：0.1-0.6 parts of choline, taurine 0.02-
0.06 part and 0.01-0.05 parts of nucleotide.Chinese medical extract can include at least one of material of following parts by weight：Ganoderma lucidum
0.25-0.75 parts of polysaccharide, 0.75-1.25 parts of astragalus polyose, 0.25-0.75 parts of tea polyphenols, dandelion or dandelion extract
0.25-0.75 parts of 3.75-7.5 parts, milk thistle or milk thistle extract and cymose buckwheat rhizome or 3-6 parts of Rhizoma Fagopyri Dibotryis extract.
Tumour full nutrition formula food provided in an embodiment of the present invention, passes through nutrient matrix, nutrition fortifier, complex mineral
Matter, multi-vitamins coordinate Chinese medical extract at the same time, and nutrition is balanced and comprehensive, and the whole of tumor patient needs is contained in product
Nutrient, and various nutrient charge ratios are designed according to the Nutrition and Metabolism rule of tumor patient, meet tumor patient
To the particular/special requirement of nutrient.The addition of a variety of Chinese herbal medicine functional active components, can improve the concentration of function factor, reduce each
The intake of kind impurity, helps to mitigate liver kidney burden, has the function that to strengthen resistance of human body.
Tumour full nutrition formula food provided in an embodiment of the present invention can be used as single source of nutrition and meet that tumour is suffered from
The nutritional need of person, can also play clearing heat and detoxicating, promoting blood circulation, dispersing swelling and dissipating binds, strengthen the body resistance to consolidate the constitution, strengthen immunity and prevention it is swollen
The effect of knurl.This product can provide accurately nutritional support for tumor patient, can reach reversing tumor patient it is malnutritive or
Cachectic situation, improves tolerance of the tumor patient to clinical treatment, assists to the clinical many treatment means of tumor disease
Implement, and then prevent associated complication and death.Can aid in reduce cancer patient medical expense and in hospital when
Between.
Ganoderma lucidum polysaccharide：One of most effective component in ganoderma lucidum, can improve immunity of organisms, improve body's hypoxia tolerance,
Free radical is eliminated, suppresses tumour, radioresistance, improves liver, marrow, blood synthetic DNA, RNA, protein-energy, extends the service life,
Ganoderma lucidum polysaccharide also has stimulation of host non-specific resistance, immune idiosyncrasy and the spy for suppressing transplantation tumor physiological activity
Property.
Astragalus polyose：One of main active of radix astragali, can be used as immunopotentiating agent or conditioning agent, while have disease-resistant
Malicious, antitumor, anti-aging, radioresistance, resisting stress, anti-oxidant etc. act on, it can improve immunity of organism in terms of tumour is treated
Power, and when other chemical synthetic drugs are used in combination, can reduce the toxicity of other chemotherapeutics, while strengthen its antitumor work
With.
Tea polyphenols：The main active of green tea, has moderate selectivity antitumor activity, tea polyphenols are in tumor prevention and control
Action target spot in treatment is extensive.Tea polyphenols have cytotoxicity, inducing apoptosis of tumour cell and differentiation, anti-distortion, anticancer
The comprehensive effects such as transfer.
Dandelion：With antibacterial, antitumor, anti-oxidant, anti-inflammatory, diuresis, antiallergy, antithrombotic, hypoglycemic, reducing blood lipid,
Hepatic cholagogic, stomach invigorating, Immune enhancement etc. act on.Dandelion can suppress tumor cell proliferation, effect tumor microenvironment, mitigate and swell
Tumor medicine side reaction.
Milk thistle：Its main anti-tumor active ingredient is the flavanolignan's class compound silymarin extracted in seed,
There are legalon, Isosilybin, silydianin, Silychristin etc..Silymarin can pass through its stronger blocks cellular week
The effect of phase and inducing apoptosis of tumour cell plays its antitumor activity.Legalon can be by inducing tumour cell to normal
Cell differentiation and it is antitumor.
Cymose buckwheat rhizome：The dry rhizome of polygonaceae plant cymose buckwheat rhizome, is clinically having for cymose buckwheat rhizome for antitumor Wei Maining
Extract is imitated, antitumor main active is tannins in cymose buckwheat rhizome.Cymose buckwheat rhizome can strengthen immunity of organisms,
Directly suppress growth of tumour cell, suppression tumor cell invasion and transfer, inducing apoptosis of tumour cell, suppress tumor vessel life
It is long.
Nucleotide：It is primarily involved in forming nucleic acid, the analog of some nucleotide can disturb nucleotide metabolism, can be used as anticancer
Medicine.
Choline：The important composition component of lecithin and sphingomyelins.Long-term dietary int ake lacks choline, can cause liver, kidney, pancreas
Adenopathy becomes, disturbance of memory and growth disorder, while can induce cancer, is gene damage first, followed by it is some can be formed it is swollen
The mutant strain of knurl grows and breeds.Intake choline can reduce the risk of cancer, be due to its as methyl in one carbon unit
Effect in metabolism, the case-control study based on crowd show that high choline intake can reduce the risk of breast cancer, reduce mammary gland
The death rate of cancer.Choline intake is related with Risk of Colorectal Cancer, and animal experiment study shows, choline, which lacks, can cause liver cancer, raises
Rat lacks feed with choline can cause liver largely to gather fat, and the animal thoughts of about 70% shortage choline are abnormal after 1 year, closely
Liver cancer occurs for 25% animal.
Taurine：A kind of semi-dispensable amino acid of sulfur-bearing, is the condition essential nutrients of people.Taurine can be used as some swollen
Knurl occurs and the marker of early diagnosis, the prevention to tumour are of great significance.Can be by improving antioxidant ability of organism, increasing
Strong immunity of organisms, inducing apoptosis of tumour cell and raising body DNA damage repair ability etc. play antitumor action.Ox sulphur
The effect of acid shares with chemotherapeutics, can improve chemotherapeutics simultaneously reduces its adverse reaction.Some taurine derivatives have
Antitumor action, can be applied to clinical treatment.
Nutrient matrix can include the material of following parts by weight：15-45 parts of carbohydrate, 3-8 parts of dietary fiber, albumen
15-45 parts of 14-28 parts of matter and fat.
Optionally, carbohydrate can include at least one of maltodextrin, xylitol and maltose.Maltodextrin
It is not required to enter directly into stomach by the hydrolysis of ptyalin, is further digested and assimilated through small intestinal mucosa enzyme, Ke Yihuan
Solution digestion pressure.Maltodextrin can make raw material with each kind of starch, and through enzymatic hydrolysis, purification drying forms.
Optionally, the energy supply percentage that each material accounts for tumour full nutrition formula food in nutrient matrix is：Carbohydrate
27%, protein 18%, fat 54%.It is formulated according to the present invention, the tumour that various components are prepared using suitable ratio collocation
Full nutrition formula food, can be in isotonic state after the dissolving of a certain amount of water, reach small intestine quickly through stomach, absorb quick, complete
Entirely, nutrition needed for tumor patient and energy can be supplemented rapidly.Effectively it can prevent and suppress the growth of tumour, shift and answer
Hair, improves quality of life, the medical expense for reducing cancer patient and the hospital stays of patient, obtains more preferable clinical effectiveness.
Dietary fiber be it is a kind of can neither be digested by digestive ferment in the intestines and stomach of the mankind, be not also absorbed by the body what is utilized
Polysaccharide.Water-soluble fibre and non-soluble fiber can be divided into.Suitable dietary fiber intake can help enterogastric peristalsis.Meals
Fiber has huge adsorption group, can take numerous harmful, poisonous factors in vitro out of.Optionally, dietary fiber can wrap
Include at least one of oligofructose, resistant starch and common oats fibre.
Optionally, protein can be included in casein, sepg whey albumen, soybean separation protein bletilla soybean peptide at least
It is a kind of.Content of the protein in tumour full nutrition formula food total material can be higher than 0.80g/100kJ.That is tumour
The quality that full nutrition formula food often provides protein in the corresponding material mass of 100kJ energy should be higher than that 0.80g.Casein,
Lactalbumin, soybean protein belong to high-quality protein, derive from a wealth of sources.
Casein is the highest albumen of content in breast, typically refers to casein sodium or calcium caseinate, is conducive to human body
Absorption to several mineral materials.Lactalbumin refers to that dissolving is dispersed in the albumen in whey, includes alpha lactalbumin, α-milky white egg
In vain, lactoferrin, beta lactoglobulin etc., have nutritive value it is high, it is easy to digest absorb, contain a variety of active ingredients, help to adjust
Section sleep, appetite and mood, are referred to as the king of albumen.
Whey can obtain whey protein concentrate by operations such as clarification, ultrafiltration, dryings, and sepg whey albumen is dense
The high-purity lactalbumin obtained on the basis of contracting lactalbumin by further process, purity is up to more than 90%.
Amino acid classes have nearly 20 kinds in soybean protein, and contain essential amino acid.It is full of nutrition, consolidate without courage
Alcohol, is one of kinds of alternative animal protein few in number in vegetable protein.Soybean peptide can be soybean protein through acid
Method or enzymatic hydrolysis or separation, it is refined obtained from mixtures of polypeptides, based on small-molecular peptides, also containing a small amount of macromolecular peptide,
The compositions such as free amino acid, carbohydrate and inorganic salts, have the function of quickly to set up, strengthen muscle strength.
Optionally, fat includes microencapsulation medium-chain fatty glyceride, microencapsulation olive oil, microencapsulation soybean oil and micro-
At least one of encapsulated fish oil.Microencapsulation fat oil is in uniform drying bulky powder shape, after hot water reconstitutes, can comparatively fast be dissolved
Into uniform emulsion, no lamination.Fat oil can be to avoid the insoluble phenomenon in reconstituting after microencapsulation is handled.
Medium-chain fatty glyceride (MCT) can be by glycerine with forming the aliphatic acid of carbochain containing 6-12 carbon atom through esterification
Reaction generation.Typical MCT can be saturation Trivent OCG or saturation Triglyceride DDD or the mixing of saturation caprylic-capric acid
Triglycerides.MCT can be trophism raw material and energy source, and small intestine is greater than long chain fatty acids to the absorbability of MCT
Glyceride, thus MCT has the advantages of digesting and assimilating soon, energy is easy to release, can be that patient quickly energize, and wait quality
The energy that provides of MCT be twice of glucose.The embodiment of the present invention increases MCT under conditions of patient's fat supply is met
Content, be conducive to tumor patient and digest and assimilate fat, mitigate burden of liver.And since tumour cell can not utilize fat to supply
Can, the nourishing to tumour cell can be reduced.
Olive oil is the grease that human nutrition is most suitable in the grease found so far.Containing abundant single insatiable hunger in olive oil
With aliphatic acid and polyunsaturated fatty acid.Polyunsaturated fatty acid includes omega-fatty acid.Fish oil is whole oils in fish body
The general name of material, its main component are omega-fatty acid, including DHA and EPA.Omega-fatty acid propagation capable of inhibiting cell, turn
Move, suppress Cellular Signaling Transduction Mediated approach, induce its differentiation, apoptosis, improve the constitution of tumor patient, improve the survival of patient
Rate, reduces tumor incidence.
Embodiment uses a variety of greases in the present invention, saturated fatty acid in product：Monounsaturated fatty acids：How unsaturated fat
Fat acid=1：1：1, contribute to the nutrition of human body balanced.The energy supply percentage that omega-fatty acid accounts for tumour full nutrition formula food can
Think 1%-6%.
Optionally, nucleotide includes 5'-CMP, 5 '-uridine monophosphate, 5'-monophosphate adenosine, 5'-inosinic acid
At least one of disodium, 5'-GMP2Na, 5'-UMP disodium and 5'-CMP disodium.Nucleotide is sought entirely in tumour
The content supported in formula food total material is less than 0.7g/100kJ.That is tumour full nutrition formula food often provides 100kJ
The quality of the corresponding material mass nucleotide of energy should be less than 0.7g.
Composite mineral matter can include the one or more in calcium, phosphorus, potassium, sodium, magnesium, iron, zinc, selenium, copper, manganese, iodine chrome molybdenum.
Mineral matter in composite mineral matter can be the organic or inorganic compound of the mineral matter.
Optionally, composite mineral matter includes the mineral matter of following parts by weight：0.10-0.5 parts of calcium, 0.05-0.4 parts of phosphorus,
0.1-1.0 parts of potassium, 0.2-0.6 parts of sodium, 0.04-0.12 parts of magnesium, 0.002-0.006 parts of iron, 0.0015-0.005 parts of zinc, 1 × 10-5-5×10-5Part selenium, 1 × 10-4-5×10-4Part copper, 5 × 10-4-1.2×10-3Part manganese, 2 × 10-5-7×10-5Part iodine, 1 × 10-5-5×10-5Part chromium and 2 × 10-5-5×10-5At least one of part molybdenum.
Multi-vitamins can include vitamin A, vitamine D3, vitamin E, vitamin K, vitamin C, vitamin B1、
Vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, the one or more in pantothenic acid and biotin.
Optionally, multi-vitamins include the vitamin of following parts by weight：2×10-4-8×10-4Part vitamin A, 4 × 10-6-1×10-5Part vitamin D3、5×10-3-1.5×10-2Part vitamin E, 2.5 × 10-5-1×10-4Part vitamin K, 0.05-
0.15 part of vitamin C, 5 × 10-4-1.5×10-3Part vitamin B1、5×10-4-1.5×10-3Part vitamin B2、5×10-4-1.5
×10-3Part vitamin B6、0-2×10-6Part vitamin B12、1.2×10-3-3.0×10-3Part nicotinic acid, 1 × 10-4-5×10-4Part
Folic acid, 1.5 × 10-3-5.0×10-3Part pantothenic acid, 1 × 10-5-4×10-5At least one of part biotin.
Preferably, tumour full nutrition formula food further includes at least one of arginine, leucine and glutamine.Can
Choosing, content of the arginine in tumour full nutrition formula food total material is higher than 0.12g/100kJ.Optionally, glutamine
Content in tumour full nutrition formula food total material is 0.04g/100kJ-0.53g/100kJ.Optionally, leucine is swollen
Content in knurl full nutrition formula food total material is higher than 0.03g/100kJ.That is tumour full nutrition formula food often carries
For in the corresponding material mass of 100kJ energy, arginic quality should be higher than that 0.12g, and the quality of glutamic acid can be 0.04g-
0.53g, the quality of leucine should be higher than that 0.03g.
Glutamine is a kind of essential amino acid, is the highest free amino acid of body burden.In wound, operation etc.
Seriously stress in the case of, body is much larger than the requirement of glutamine the yield of endogenous glutamin, supplements glutamy
Amine can play the role of improving tumor patient body's immunity, lower infection risk.Leucine and its metabolite can be reduced
The decomposition of muscle protein and liver protein, promotes albumen synthesis, reduces consuming excessively for protein, correct negative nitrogen balance.Smart ammonia
Acid is the half necessary or necessary amino acid of conditionity of mammal, supplement arginine can play enhancing patient immune function,
Reduce the effect of the incidence of postoperative infection.
The embodiment of the present invention also provides a kind of preparation method of powder-type tumour full nutrition formula food, including：
S110, Chinese medical extract, carbohydrate, protein, fat, dietary fiber, nucleotide, ox sulphur are weighed by proportioning
Acid, choline, crushed 80 mesh sieves, is uniformly mixed, is uniformly mixed afterwards with mineral substance premix and vitamin premix, obtains mixture
Material；
S120, by the dissolving of said mixture material, drying and will be granulated；And
S130, by said mixture material through being granulated products therefrom quantitative separating, obtains the full nutrient formulation food of powder-type tumour
Product.
The present invention also provides a kind of preparation method of emulsion-type tumour full nutrition formula food, including：
S210, Chinese medical extract, carbohydrate, protein, fat, dietary fiber, nucleotide, ox sulphur are weighed by proportioning
Acid, choline, crushed 80 mesh sieves, are uniformly mixed, are uniformly mixed afterwards with mineral substance premix and vitamin premix, obtain mixture
Material；
S220, said mixture material is dissolved, and adds emulsifying agent constant volume, obtains emulsion product；
S230, inserts 10min in colloid mill, and high-pressure homogeneous, degassing by emulsion product, obtains feed liquid；And
S240, by gained feed liquid heating, canned and sterilize, after packaging emulsion-type tumour full nutrition formula food.
Preferably, the preparation of dandelion extract, may comprise steps of：
S10, dandelion add water microwave abstracting；
S20, the medicinal extract that proportion is 1.1-1.15 is concentrated under reduced pressure into by extract；And
S30, is spray-dried to obtain extract powder.
The preparation method of milk thistle or Rhizoma Fagopyri Dibotryis extract can be the same as the preparation method of dandelion extract.
1 tumour full nutrition formula food of embodiment
Component and content：
Nutrient matrix：Maltodextrin 30.00g, casein sodium 3.00g, sepg whey albumen 8.00g, soybean separation protein
White 9.00g, soybean peptide 1.00g, soybean oil 5.00g, fish oil 19.00g, medium-chain fatty glyceride 1.00g, olive oil 5.00g,
Oligofructose 2.00g, resistant starch 1.00g, common oats fibre 2.00g；
Nutrition fortifier：Choline 0.40g, taurine 0.04g, nucleotide 0.02g；
Composite mineral matter：Compound macro mineral 4.363g, compounding trace mineral 0.436g；
Compound vitamin：0.436g；
Chinese medical extract：Ganoderma lucidum polysaccharide 0.5g, astragalus polyose 1.0g, tea polyphenols 0.5g, milk thistle extract 0.5g, Pu Gong
English extract 5.0g, Rhizoma Fagopyri Dibotryis extract 4.0g；
Amino acid：Arginine 3.00g, leucine 1.00g, glutamine 5.00g；
Wherein,
0.436 gram of compounding vitamin is 0.250mg vitamin As, 0.005mg ties up raw D3,7.000mg vitamin E,
0.028mg vitamin Ks, 79.200mg vitamin Cs, 0.616mg vitamin B1s, 0.616mg vitamin B2s, 0.616mg vitamins
B6,0.001mg vitamin B12,1.760mg nicotinic acid, 0.114mg folic acid, 2.552mg pantothenic acid, 0.019mg biotins and auxiliary material
Mixture.
4.363 grams of compounding macro minerals are 284mg calcium, 223mg phosphorus, 568mg potassium, 422mg sodium, 98mg magnesium and its auxiliary material
Mixture.
0.436 gram compounding trace mineral be 4.4mg iron, 3.3mg zinc, 0.022mg selenium, 0.308mg copper, 0.88mg manganese,
0.044mg iodine, 0.022mg chromium, the mixture of 0.035mg molybdenums and auxiliary material.
Extraction：Add water microwave abstracting to dandelion, milk thistle, cymose buckwheat rhizome, it is 1.1- that extract, which is concentrated under reduced pressure into proportion,
1.15 medicinal extract, is spray-dried to obtain extract powder；
Batch mixing：By load weighted above-mentioned dandelion, milk thistle and Rhizoma Fagopyri Dibotryis extract powder, ganoderma lucidum polysaccharide, astragalus polyose, tea
Polyphenol, carbohydrate, protein, fat, dietary fiber, choline, nucleotide, taurine, amino acid etc. mix, afterwards and mineral
Matter premix, vitamin premix are uniformly mixed, and obtain mixed material；
It is granulated：By the dissolving of said mixture material, dry and granulation；
Quantitative separating：To the material quantitative separating after granulation, 500g/ tanks.
2 tumour full nutrition formula food of embodiment
Component：Difference from Example 1 is to also added xanthans 0.26g, diand monoglycerides aliphatic acid 1.09g
And phosphatidase 0 .87g.
Dispensing：By load weighted maltodextrin, microencapsulation soybean oil, microencapsulation fish oil, microencapsulation medium chain fatty acid
Fat and microencapsulation olive oil, casein sodium, sepg whey albumen, soybean protein isolate, soybean peptide, xanthans, list, diglycerol
Fatty acid ester, phosphatide, Chinese medical extract, choline, nucleotide, taurine, vitamin, mineral matter, amino acid etc. are uniformly mixed, and are obtained
Mixed material
Dissolve constant volume：Mixed material is dissolved in the water, suitable volume is settled to, obtains feed liquid.
Homogenization：Feed liquid is poured into through the clean colloid mill of wash cycles, circular treatment 10min, feed liquid is released, through height
Press homogeneous spare after deaerating；
Filling, sterilizing：Material through homogeneous is heated, it is canned, sterilize, sealing.
Comparative example 1 is free of the tumour full nutrition formula food of Chinese medical extract
Difference lies in without Chinese medical extract composition with embodiment 1.
2 conventional feed of comparative example
Conventional feed is commercial product.
1 tumour full nutrition formula food of experimental example is to SPF mouse species experimental studies
Experiment purpose：Tumour full nutrition formula food is to no-special pathogen (SPF) mouse weight, tumor mass weight, spleen
The influence of index and thymus index.
Test material：The tumour full nutrition formula food of embodiment 1, the tumour without Chinese medical extract of comparative example 1 are complete
The conventional feed of nutritional formulas, comparative example 2.
Experimental animal：SPF mouse, weight 18-22g, half male and half female.
Experimental enviroment condition：22-23 DEG C of temperature, humidity 52-58%.
Test method：S180 knurls liquid is extracted under aseptic condition and presses 1 with physiological saline：3 dilutions, obtain knurl liquid dilution；Take
0.2ml tumours dilution is subcutaneous by the aseptic technique injection right armpit of mouse, 24 it is small when after weigh to mouse, and be randomly divided into 3
Group, is respectively lotus knurl control group, experimental group, goes Chinese medicine control group, every group of animal 12.Wherein lotus knurl control group comparative example 2
In conventional feed feed, tumour full nutrition formula food made from experimental group embodiment 1 is fed, go Chinese medicine control group with pair
The tumour full nutrition formula food without Chinese medical extract is fed in ratio 1.
Another to take the normal SPF mouse of suitable 12 of weight, half male and half female, is inoculated with normal saline and is used as false inoculation group,
The daily conventional feed given in comparative example 2 is fed, as Normal group.
It is grouped and was fed in the same day to food, free water, 22-23 DEG C of laboratory temperature, relative humidity 52-58%, and keep
Good illumination and ventilation condition, daily set time segment record mouse active situation are co-continuous to give food 14 days.After the last administration
Next day puts to death mouse, accurately weighs mouse weight with electronic balance, peels off subcutaneous tumor mass, spleen and thymus gland and weigh, and calculate
Index and spleen index and thymus index.T is examined between experimental result carries out group.Index and spleen index=spleen weight (mg)/weight (g), thymus gland
Index=thymic factor D injection (mg)/weight (g).
Result of the test：
1) influence of the tumour full nutrition formula food to SPF mouse weights and tumor mass
It refer to table 1, it can be seen that before each group mouse enters group, weight differences are not statistically significant (P ＞ 0.05).14 days
Afterwards, compared with before starting to food, each group mouse weight substantially increases (P ＜ 0.05).After experiment, with Normal group phase
Than lotus knurl control group, experimental group and going Chinese medicine control group mice body weight increase speed slow, changing not statistically significant (P ＞
0.05), it may be possible to which lotus knurl state, medicine are in itself and injection stimulus effects mouse growth is developed.With lotus knurl control group and removing Chinese medicine
Control group compares, and experimental mice body weight increase speed is fast, changes statistically significant (P ＜ 0.05).Experimental group is averaged knurl weight
Less than removing Chinese medicine control group and lotus knurl control group is averaged knurl weight, but no significant difference (P ＞ 0.05).Illustrate of the invention real
The growth of tumour can effectively be suppressed by applying a tumour full nutrition formula food, while more comprehensive nutrition can be provided for mouse
Material, mitigation mouse phenomenon of weight loss because of effects of tumors.
Influence (n=12, x ± s) of the 1 tumour full nutrition formula food of table to SPF mouse weights (g)
| Weigh the time | Start weight (g) | Terminate weight (g) | Tumor mass weight (g) |
| Normal group | 20.28±1.3 | 25.28±2.1 | -- |
| Lotus knurl control group | 19.35±1.2 | 24.22±1.8 | 1.83±0.25 |
| Experimental group | 19.42±1.3 | 24.86±1.9 | 1.75±0.30 |
| Remove Chinese medicine control group | 19.31±1.2 | 24.72±1.7 | 1.78±0.31 |
2) influence of the tumour full nutrition formula food to SPF mouse spleens index and thymus index
Thymus gland is the central immune organ of immune system, can maintain the normal immunologic balance of body, is regulation and control siberian crabapple
The principal endocrine gland of system, has and establishes the effect such as self tolerance, immunological regulation and barrier antigens, is lymphocyte differentiation, hair
Educate and ripe place, while also assist in and adjust periphery mature cell, avoid autoimmune disease, inflammation, hyperblastosis and
The generation of the diseases such as thymoma.Spleen is internal maximum peripheral immune organ, in immunity of organism, especially in antineoplastic immune side
Highly important status is occupied in face, and spleen participates in tumour immunity rich in substantial amounts of immunocyte and immune factor, as lymphocyte,
Macrophage, cell and opsonin, complement etc., therefore one of immune function can be used as.Thymus and Spleen index is straight
The reversed important parameter for reflecting immune status.Immune response is participated in by different mechanism, plays immune function.
Influence (n=12, x ± s) of the 2 tumour full nutrition formula food of table to SPF mouse spleens index and thymus index
| Index and spleen index | Thymus index | |
| Normal group | 8.87±0.76 | 3.92±0.31 |
| Lotus knurl control group | 6.08±0.64 | 2.31±0.23 |
| Experimental group | 8.52±0.91 | 4.03±0.37 |
| Remove Chinese medicine control group | 6.41±0.84 | 2.50±0.35 |
Table 2 is refer to, compared with Normal group, the index and spleen index of lotus knurl control group mice substantially reduces (P ＜ 0.05)；
With lotus knurl control group and compared with removing Chinese medicine control group, the wherein rise of experimental group index and spleen index, experimental group index and spleen index rise difference
Statistically significant (P ＜ 0.05).
Compared with Normal group, the thymus index of lotus knurl control group mice substantially reduces (P ＜ 0.05)；Compareed with lotus knurl
Group and Chinese medicine control group is gone to compare, experimental group thymus index rise, wherein experimental group thymus index rise difference has statistics meaning
Adopted (P ＜ 0.05).
Experimental result shows that tumour specific full nutritional formulas provided in an embodiment of the present invention can significantly improve mouse chest
Gland index and index and spleen index, can effectively improve the immunocompetence of mouse, improve Immunologic States, strengthen anti-infective energy
Power.May infer that for improve tumor patient resist disease ability, improve tumour suffer from life quality have the function that it is positive.
2 tumour full nutrition formula food of experimental example swallows dimethyl diaminophenazine chloride functional examination to SPF Turnover of Mouse Peritoneal Macrophages
Experiment purpose：Influence of the tumour full nutrition formula food to SPF Turnover of Mouse Peritoneal Macrophages phagocytosis dimethyl diaminophenazine chloride function.
Test material：The tumour full nutrition formula food of embodiment 1, the tumour without Chinese medical extract of comparative example 1 are complete
The conventional feed of nutritional formulas, comparative example 2.
Experimental animal：SPF mouse, weight 18-22g, half male and half female.
Experimental enviroment condition：22-23 DEG C of temperature, humidity 52-58%.
Test method：Earlier stage processing method is identical with experimental example 1, is in the difference of experimental example 1：In each group mouse
The 14th day of medication, when small to the sterile starch meat soup 1ml of every mouse peritoneal injection 6%, 1 after, take a blood sample from orbital venous plexus
Mouse is put to death, then soaks 3min, dorsal position with ethanol in super-clean bench, then to Intraperitoneal injection 2ml 1640 culture mediums, gently rub
Belly 3min, opens abdominal cavity, collects peritoneal fluid centrifuge washing, draws the complete 1640 culture mediums of 1ml and cell is resuspended, adjustment cell is dense
Degree, takes 0.1ml cell suspensions to add culture plate culture, and 2h is incubated in 37 DEG C, 5%CO2 incubators, removes nutrient solution, per hole
0.072% neutral red solution 0.1ml is added, continues to cultivate 3h, cell is cleaned 3 times with the 1640 culture medium of serum-free, per hole
Cell pyrolysis liquid is added, 4 DEG C of refrigerators are stood overnight, and measure absorbance (OD) value under 570nm with microplate reader.Experimental result carries out
T is examined between group.
Macrophage can adjust non-specific and specific immune response, be the important target cell of immunocompetence polysaccharide.
Test in group of formula, containing the component such as polysaccharide and tea polyphenols, polysaccharide can direct activating macrophage, strengthen its phagocytic activity,
So as to improve immunity.For macrophage as most important phagocyte in immune system, the power of phagocytic activity is that reflection is huge
The important indicator of phagocyte function.As a result experimental group absorbance according to Group apparently higher than to, with removing Chinese medicine control group, showing macrophage
The phagocytic activity enhancing of cell, experimental group can strengthen patient to a certain extent because with the addition of the materials such as ganoderma lucidum polysaccharide, astragalus polyose
Immunity, improves it and resists the ability of disease.
3 tumour full nutrition formula food of table to Turnover of Mouse Peritoneal Macrophages phagocytosis dimethyl diaminophenazine chloride ability influence (n=12, x ±
s)
| Group | Swallow dimethyl diaminophenazine chloride (OD570nm) |
| Normal group | 0.94±0.11 |
| Lotus knurl control group | 0.72±0.09 |
| Experimental group | 1.43±0.15 |
| Remove Chinese medicine control group | 0.85±0.15 |
Table 3 is refer to, compared with Normal group, lotus knurl control group absorbance substantially reduces (P ＜ 0.05)；With lotus knurl
Control group compares, and experimental group can significantly improve the phagocytosis dimethyl diaminophenazine chloride function (P ＜ 0.05) of Turnover of Mouse Peritoneal Macrophages.Remove Chinese medicine pair
Raised according to group absorbance compared with lotus knurl control group, but it is not statistically significant.Test result indicates that tumour of the embodiment of the present invention is sought entirely
Foster formula food can effectively improve the immune function of mouse.May infer that for improve tumor patient resist disease ability,
Improve tumour suffer from life quality have the function that it is positive.
3 tumour full nutrition formula food of experimental example is to SD rat animal experimental studies
Experiment purpose：Influence of the tumour full nutrition formula food to SD rats blood routine and Biochemical Indices In Serum.
Test material：The tumour full nutrition formula food of embodiment 1, the tumour without Chinese medical extract of comparative example 1 are complete
The conventional feed of nutritional formulas, comparative example 2.
Experimental animal：SD rats 48, weight 18-22g, half male and half female.
Experimental enviroment condition：22-23 DEG C of temperature, humidity 52-58%.
Test method：Weigh after being fed 3 days to SD rats adaptability, be randomly divided into 3 groups according to gender weight, respectively just
Normal control group, experimental group, remove Chinese medicine control group, every group 16, half male and half female.Wherein Normal group is with normal in comparative example 2
Tumour full nutrition formula food made from rule forage feed, experimental group embodiment 1 feeds, goes Chinese medicine control group comparative example 1
In without Chinese medical extract tumour full nutrition formula food feed.Continuous feeding 2 weeks, weekly carries out animal in the set time
Weigh.At the end of experiment, anesthetized animal, in 2 parts of abdominal aortic blood, portion does blood routine detection, and portion centrifugation, takes serum to do
The detection of biochemical indicator.
Result of the test：
1) influence of the tumour full nutrition formula food to SD rat body weights
Table 4 is refer to, compared with Normal group, experimental group and Chinese medicine control group raising rat is removed weight has been after 2 weeks
Mitigate, but there was no significant difference for statistics, it may be possible to because influence of the animal to adaptation process such as new food mouthfeels.
Influence (n=16, x ± s) of the 4 tumour full nutrition formula food of table to SD rat body weights (g)
| Weigh the time | Time started | 7th day | 14th day |
| Normal group | 208.46±14.03 | 221.81±30.38 | 243.46±39.10 |
| Experimental group | 207.89±12.78 | 218.66±31.91 | 239.94±31.63 |
| Remove Chinese medicine control group | 207.54±13.01 | 216.57±30.28 | 236.72±31.17 |
2) influence of the tumour full nutrition formula food to SD rat blood serum biochemical indicators
5 tumour full nutrition formula food of table is to SD rat blood serum biochemistry statistical result (n=16, x ± s)
| Project name | Control group | Experimental group | Remove Chinese medicine control group |
| Glutamic-pyruvic transaminase | 95.81±33.50 | 99.14±26.08 | 97.26±24.67 |
| Glutamic-oxalacetic transaminease | 207.93±82.92 | 167.66±53.20 | 181.53±50.37 |
| Urea nitrogen | 8.00±1.45 | 8.03±1.18 | 8.08±1.09 |
| Creatinine | 26.15±4.58 | 21.66±1.94 | 23.52±2.21 |
| T-CHOL | 1.52±0.24 | 1.39±0.32 | 1.45±0.37 |
| Triglycerides | 0.82±0.29 | 0.90±0.39 | 0.87±0.41 |
| High-density lipoprotein cholesterol | 0.58±0.10 | 0.72±0.19 | 0.75±0.18 |
Table 5 is refer to, tumour full nutrition formula food replaces feed, and raising SD rats after two weeks do not refer to its serum biochemistry
Mark produces significantly significant change.
3) influence of the tumour full nutrition formula food to SD rat blood routines
6 tumour full nutrition formula food of table is to SD rat serum conventional statistics result (n=16, x ± s)
| Project name | Normal group | Experimental group | Remove Chinese medicine control group |
| Leucocyte | 16.21±8.07 | 20.24±11.22 | 19.02±10.87 |
| Neutrophil leucocyte | 2.15±0.91 | 2.33±1.23 | 2.27±1.05 |
| Lymphocyte | 11.62±5.07 | 12.11±7.03 | 11.87±6.96 |
| Monocyte | 1.03±0.80 | 0.94±0.77 | 0.92±0.74 |
| Eosinophil | 0.10±0.07 | 0.08±0.06 | 0.08±0.05 |
| Basophilic granulocyte | 0.03±0.02 | 0.07±0.09 | 0.06±0.08 |
| Neutrophil leucocyte ratio | 15.25±4.18 | 16.35±6.95 | 16.08±6.67 |
| Lymphocyte ratios | 78.43±5.58 | 77.97±8.65 | 77.85±8.71 |
| Monocyte ratio | 5.70±2.78 | 5.24±2.34 | 5.36±2.30 |
| Eosinophil ratio | 0.73±0.46 | 0.39±0.17 | 0.51±0.23 |
| Basophilic granulocyte ratio | 0.25±0.14 | 0.25±0.16 | 0.24±0.15 |
| Red blood cell | 6.60±0.44 | 6.89±0.77 | 6.77±0.75 |
| Hemoglobin | 123.69±7.17 | 130.27±16.40 | 125.77±16.18 |
| Packed cell volume | 38.29±2.19 | 40.79±4.46 | 39.37±3.28 |
| Mean corpuscular volume (MCV) | 57.95±2.60 | 59.29±2.26 | 59.03±2.48 |
| Average hemoglobin content | 18.65±0.64 | 18.89±0.57 | 18.74±0.61 |
| Mean hemoglobin concentration | 302.20±13.48 | 318.87±10.77 | 311.55±16.85 |
| Erythrocyte distribution width | 15.79±1.55 | 17.31±2.15 | 16.28±2.02 |
| Blood platelet | 1136.25±193.17 | 1003.53±330.36 | 1097.36±270.54 |
| Thrombocytocrit | 0.86±0.17 | 0.78±0.24 | 0.82±0.27 |
| Platelet distribution width | 7.88±0.61 | 8.86±1.06 | 8.27±0.96 |
| Mean platelet volume | 7.41±0.64 | 7.87±0.56 | 7.71±0.54 |
Table 6 is refer to, experimental result shows that tumour full nutrition formula food replaces feed, and raising SD rats are not right after two weeks
Its routine blood indexes produces significantly significant change.
Tumour of embodiment of the present invention specific full nutritional formulas is meeting human normal fat, protein, vitamin, micro-
On the basis of the nutrient profiles such as secondary element, the Chinese medicine strengthened the body resistance to consolidate the constitution is equipped with, the vital sign of intact animal is not produced substantially
Influence, blood routine and Biochemical Indices In Serum without substantially changeing, illustrate edible safety.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope that this specification is recorded all is considered to be.
Embodiment described above only expresses the several embodiments of the present invention, its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (14)
1. a kind of tumour full nutrition formula food, includes the material of following parts by weight：
47-126 parts of nutrient matrix, 0.13-0.71 parts of nutrition fortifier, 2.5-7.5 parts of composite mineral matter, multi-vitamins 0.1-
1.0 parts and 8.25-17 parts of Chinese medical extract；
The Chinese medical extract includes at least one of material of following parts by weight：0.25-0.75 parts of ganoderma lucidum polysaccharide, radix astragali are more
0.75-1.25 parts sugared, 0.25-0.75 parts of tea polyphenols, 3.75-7.5 parts of dandelion extract, milk thistle extract 0.25-0.75
3-6 parts of part and Rhizoma Fagopyri Dibotryis extract.
2. tumour full nutrition formula food according to claim 1, it is characterised in that the nutrient matrix includes following heavy
Measure the material of part：15-45 parts of 15-45 parts of carbohydrate, 3-8 parts of dietary fiber, 14-28 parts of protein and fat.
3. tumour full nutrition formula food according to claim 2, it is characterised in that the carbohydrate accounts for described swollen
The energy supply percentage of knurl full nutrition formula food is 27%, and the protein accounts for the energy supply hundred of the tumour full nutrition formula food
Divide than being 18%, the energy supply percentage that the fat accounts for the tumour full nutrition formula food is 54%.
4. tumour full nutrition formula food according to claim 2, it is characterised in that
The carbohydrate includes at least one of maltodextrin, xylitol and maltose；
The dietary fiber includes at least one of oligofructose, resistant starch and common oats fibre；
The protein includes at least one of casein, sepg whey albumen, soybean separation protein bletilla soybean peptide.
5. tumour full nutrition formula food according to claim 2, it is characterised in that the protein is complete in the tumour
Content in nutritional formulas total material is higher than 0.80g/100kJ.
6. tumour full nutrition formula food according to claim 2, it is characterised in that the fat includes chain in microencapsulation
At least one of fatty glyceride, microencapsulation olive oil, microencapsulation soybean oil and microencapsulation fish oil.
7. tumour full nutrition formula food according to claim 2, it is characterised in that contain ω -3 fat in the fat
Acid, the energy supply percentage that the omega-fatty acid accounts for the tumour full nutrition formula food are 1%-6%.
8. tumour full nutrition formula food according to claim 1, it is characterised in that the nutrition fortifier includes following
The material of parts by weight：0.01-0.05 parts of 0.1-0.6 parts of choline, 0.02-0.06 parts of taurine and nucleotide.
9. tumour full nutrition formula food according to claim 8, it is characterised in that the nucleotide includes 5 '-mono- phosphorus
Sour cytidine, 5 '-uridine monophosphate, 5'-monophosphate adenosine, 5'-inosinic acid disodium, 5'-GMP2Na, 5'-UMP disodium
And at least one of 5'-CMP disodium.
10. tumour full nutrition formula food according to claim 8, it is characterised in that the nucleotide is in the tumour
Content in full nutrition formula food total material is less than 0.7g/100kJ.
11. tumour full nutrition formula food according to claim 1, it is characterised in that the composite mineral matter include with
The mineral matter of lower parts by weight：0.10-0.5 parts of calcium, 0.05-0.4 parts of phosphorus, 0.1-1.0 parts of potassium, 0.2-0.6 parts of sodium, 0.04-0.12
Part magnesium, 0.002-0.006 parts of iron, 0.0015-0.005 parts of zinc, 1 × 10-5-5×10-5Part selenium, 1 × 10-4-5×10-4Part copper, 5
×10-4-1.2×10-3Part manganese, 2 × 10-5-7×10-5Part iodine, 1 × 10-5-5×10-5Part chromium and 2 × 10-5-5×10-5Part molybdenum
At least one of.
12. tumour full nutrition formula food according to claim 1, it is characterised in that the multi-vitamins include with
The vitamin of lower parts by weight：2×10-4-8×10-4Part vitamin A, 4 × 10-6-1×10-5The raw D of part dimension3、5×10-3-1.5×
10-2Part vitamin E, 2.5 × 10-5-1×10-4Part vitamin K, 0.05-0.15 parts of vitamin Cs, 5 × 10-4-1.5×10-3Part
Vitamin B1、5×10-4-1.5×10-3Part vitamin B2、5×10-4-1.5×10-3Part vitamin B6、0-2×10-6Part dimension life
Plain B12、1.2×10-3-3.0×10-3Part nicotinic acid, 1 × 10-4-5×10-4Part folic acid, 1.5 × 10-3-5.0×10-3Part pantothenic acid and 1
×10-5-4×10-5At least one of part biotin.
13. tumour full nutrition formula food according to claim 1, it is characterised in that further include arginine, leucine,
At least one of glutamine.
14. tumour full nutrition formula food according to claim 13, it is characterised in that the arginine is in the tumour
Content in full nutrition formula food total material is higher than 0.12g/100kJ；The glutamine is in the full nutrient formulation of the tumour
Content in food total material is 0.04g/100kJ-0.53g/100kJ；The leucine is in the full nutrient formulation food of the tumour
Content in product total material is higher than 0.03g/100kJ.
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| CN201711287325.2A CN107981339A (en) | 2017-12-07 | 2017-12-07 | Tumour full nutrition formula food |
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| CN111220604A (en) * | 2019-12-06 | 2020-06-02 | 东北农业大学 | Method for measuring total starch content in meat product |
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| CN114794460A (en) * | 2022-05-10 | 2022-07-29 | 华中农业大学 | Immunity-enhanced full-nutrition formula food with special medical application |
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