CN111467389A - Traditional Chinese medicine pill for treating cerebral apoplexy and preparation method thereof - Google Patents
Traditional Chinese medicine pill for treating cerebral apoplexy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine pill for treating cerebral apoplexy and a preparation method thereof, wherein the traditional Chinese medicine pill comprises the following raw materials in parts by weight: 3-5 parts of angelica, 0.8-1.3 parts of ligusticum chuanxiong hort, 2-3.5 parts of frankincense, 2.5-3.5 parts of myrrh, 3-5 parts of bighead atractylodes rhizome, 0.5-1 part of centipede, 0.1-0.3 part of leech, 1-2 parts of white muscardine silkworm, 1-2.5 parts of liquorice, 5-7 parts of achyranthes bidentata, 0.2-0.4 part of nux vomica and 20-30 parts of honey. Has the advantages that: the ligusticum wallichii, the frankincense, the myrrh, the leech and the radix achyranthis bidentatae in the medicine can promote blood circulation to remove blood stasis, dredge collaterals to relieve pain, lower blood pressure and lower blood fat; scolopendra and Bombyx Batryticatus have effects of dispelling pathogenic wind, relieving pain, removing toxic substance and resolving hard mass; the white atractylodes rhizome, the honey and the liquorice can tonify qi, calm the nerves, moisten lung, relieve cough, improve sleep quality and improve human immunity; can be used for treating dizziness, headache, numbness of limbs, slurred speech, and hemiplegia caused by mild and moderate cerebral apoplexy, and has good therapeutic effect on arthritis caused by arthralgia due to wind-cold-dampness.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine pill for treating cerebral apoplexy and a preparation method thereof.
Background
Stroke is also known as stroke and cerebrovascular accident. Is an acute cerebrovascular disease, which is a group of diseases causing brain tissue damage due to sudden rupture of cerebral vessels or failure of blood flow into the brain due to vessel occlusion, including ischemic and hemorrhagic stroke. The incidence rate of ischemic stroke is higher than hemorrhagic stroke, and accounts for 60-70% of the total stroke. Occlusion and stenosis of internal carotid and vertebral arteries can cause ischemic stroke, which is more than 40 years old, more female than male, and death in severe cases. Mortality from hemorrhagic stroke is high. The investigation shows that the urban and rural total stroke becomes the first death reason in China and is also the leading cause of the disability of adults in China, and the stroke has the characteristics of high morbidity, high mortality and high disability rate. Different types of stroke have different treatment modes. Due to the constant lack of effective treatments, prevention is currently considered to be the best measure, with hypertension being an important controllable risk factor for stroke.
At present, the method for clinically treating the cerebral apoplexy mainly comprises the steps of taking aspirin, clopidogrel, a brain active tablet, Mikebao and the like, has relatively reliable curative effect and targeted curative medication, wherein the aspirin is the basic medication for preventing and treating the cerebral apoplexy and has certain curative effect on preventing the recurrence of the cerebral apoplexy, and although the curative effect of the above treatment method is obvious, the method can generate various side effects to cause injury to human bodies. However, aspirin in clinical application shows that 47% of patients have medication resistance, and even aspirin enteric-coated tablets can cause burden and influence on the stomach and intestine.
Disclosure of Invention
The invention aims to solve the problems and provide a traditional Chinese medicine pill for treating cerebral apoplexy and a preparation method thereof.
The invention realizes the purpose through the following technical scheme:
a traditional Chinese medicine pill for treating cerebral apoplexy is composed of the following raw materials in parts by weight: 3-5 parts of angelica, 0.8-1.3 parts of ligusticum chuanxiong hort, 2-3.5 parts of frankincense, 2.5-3.5 parts of myrrh, 3-5 parts of bighead atractylodes rhizome, 0.5-1 part of centipede, 0.1-0.3 part of leech, 1-2 parts of white muscardine silkworm, 1-2.5 parts of liquorice, 5-7 parts of achyranthes bidentata, 0.2-0.4 part of nux vomica and 20-30 parts of honey.
Further, the material comprises the following raw materials in parts by weight: 3 parts of angelica, 0.8 part of ligusticum chuanxiong hort, 2 parts of frankincense, 2.5 parts of myrrh, 3 parts of bighead atractylodes rhizome, 0.5 part of centipede, 0.1 part of leech, 1 part of white muscardine silkworm, 1 part of liquorice, 5 parts of achyranthes bidentata, 0.2 part of nux vomica and 20 parts of honey.
Further, the material comprises the following raw materials in parts by weight: 5 parts of angelica, 1 part of ligusticum chuanxiong hort, 3 parts of frankincense, 3 parts of myrrh, 5 parts of bighead atractylodes rhizome, 1 part of centipede, 0.2 part of leech, 1.5 parts of white muscardine silkworm, 2 parts of liquorice, 6 parts of achyranthes root, 0.3 part of nux vomica and 25 parts of honey.
Further, the material comprises the following raw materials in parts by weight: 5 parts of angelica, 1.3 parts of ligusticum chuanxiong hort, 3.5 parts of frankincense, 3.5 parts of myrrh, 5 parts of bighead atractylodes rhizome, 1 part of centipede, 0.3 part of leech, 2 parts of white muscardine silkworm, 2.5 parts of liquorice, 7 parts of achyranthes bidentata, 0.4 part of nux vomica and 30 parts of honey.
Further, the feed additive is composed of the following raw materials in parts by weight: 4 parts of angelica, 0.9 part of ligusticum chuanxiong hort, 2.5 parts of frankincense, 2.2 parts of myrrh, 4 parts of bighead atractylodes rhizome, 0.8 part of centipede, 0.2 part of leech, 1.3 parts of white muscardine silkworm, 1.5 parts of liquorice, 5.5 parts of achyranthes root, 0.3 part of nux vomica and 25 parts of honey.
The invention also provides a preparation method of the traditional Chinese medicine pill for treating cerebral apoplexy, which comprises the following steps:
step one, adding a certain amount of yellow wine into clean angelica slices, uniformly stirring, slightly moistening, putting the mixture into a stir-frying container after the wine is completely absorbed, heating the mixture by slow fire, stir-frying the mixture to be dark yellow, taking out the mixture, and cooling the mixture for later use, wherein 10kg of yellow wine is used for every 100kg of angelica slices;
step two, spraying the ligusticum wallichii slices with yellow wine uniformly, slightly stewing, frying in a pot until the temperature is slightly burnt, taking out and cooling for later use, wherein 50kg of the ligusticum wallichii slices are sprayed with 6.4kg of the yellow wine;
step three, taking clean frankincense, adding vinegar, uniformly stirring, stewing thoroughly, frying in a pot until the surface is bright, taking out, and cooling for later use, wherein 5kg of vinegar is used for every 100kg of frankincense;
step four, taking clean myrrh, adding vinegar, uniformly stirring, stewing thoroughly, frying in a pot until the surface is bright, taking out, cooling for later use, and adding 5kg of vinegar for every 100kg of myrrh;
step five, taking the clean white atractylodes rhizome slices, scattering the honey-fried bran into a hot pot, adding the white atractylodes rhizome slices when smoking, frying the white atractylodes rhizome slices until the white atractylodes rhizome slices are brown and the smell of the honey escapes, screening the honey-fried bran, taking out the honey-fried bran and cooling the honey-fried bran to obtain fried white atractylodes rhizome for later use, wherein 10kg of honey-fried bran is used for every 100kg of white atractylodes rhizome slices;
step six, taking the clean centipedes, removing heads and feet, placing the cleaned centipedes in a stir-frying container, baking the cleaned centipedes with slow fire until the black brown color is crisp, taking out the centipedes, and cooling the centipedes for later use;
step seven, scattering clean white muscardine silkworms into a hot pot by using bran, adding the white muscardine silkworms when smoke is emitted, frying to be yellow, taking out the white muscardine silkworms, screening off the bran, and cooling for later use, wherein 100kg of the white muscardine silkworms is used by 10kg of the bran;
step eight, taking clean nux vomica, scattering the clean nux vomica into a hot pot by using sand, adding the nux vomica when smoke is emitted, frying the nux vomica to brown yellow and swelling, screening out the sand, taking out and cooling the nux vomica for later use;
grinding the roasted Chinese angelica, the ligusticum chuanxiong hort processed with wine, the frankincense processed with vinegar, the myrrh processed with vinegar, the white atractylodes rhizome fried with bran, the fried centipede, the white muscardine silkworm fried with bran, the fried nux vomica, the leech, the liquorice and the achyranthes bidentata into powder, mixing the powder evenly, adding the honey and kneading the mixture into honeyed pills;
step ten, packaging the honeyed pills.
Further, in the eighth step, the stir-frying temperature of the nux vomica is 270-300 ℃.
Further, in the ninth step, the medicine is ground into powder and then screened by a 120-mesh pharmacopoeia sieve.
Further, in the ninth step, each honeyed pill is 3 g.
The medicinal material efficacy analysis of the invention is as follows:
chinese angelica: sweet and pungent in flavor and warm in nature, and enter liver, heart and spleen meridians; the main functions of the traditional Chinese medicine are blood enriching, blood activating, menstruation regulating, pain relieving, dryness moistening, intestine smoothing, blood deficiency syndrome, irregular menstruation, amenorrhea, dysmenorrhea, abdominal mass and mass, metrorrhagia, deficiency cold, abdominal pain, flaccidity and paralysis, numbness of skin, intestinal dryness, difficulty in defecation, severe dysentery, carbuncle, sore and ulcer, and traumatic injury; because the angelica is specially used for blood system of people and the wine is good at promoting blood circulation, the effect of the angelica processed by the wine can be strengthened when entering blood system; moreover, the angelica has the functions of enriching and activating blood, the wine can' act as a medicine, and the angelica processed by the wine can also strengthen the effects of enriching and activating blood; in addition, although the angelica can activate blood, but the nature is soft, the walking is slow when entering blood system, the wine body is smooth and smooth, the flow is the fastest, and the angelica can be processed to promote the angelica to go up the head and chest, go down the waist and the feet, go out to the skin, go inside and viscera to treat all blood system pathological changes;
ligusticum wallichii: pungent taste and warm nature; entering liver, gallbladder and pericardium; the functional indications are as follows: has effects in promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia; the rhizoma Ligustici Chuanxiong processed with wine can be used for treating chest and hypochondrium pain, rheumatalgia, abdominal mass, pyocutaneous disease, swelling and pain, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, puerperal pain due to blood stasis; the wine-processed rhizoma ligustici wallichii, pungent in flavor, capable of dispersing warm and dredging, has the functions of activating blood and removing stasis, has wide effects, and is suitable for various diseases caused by blood stasis, in particular gynecological menstruation regulating essential drugs; the rhizoma Ligustici Chuanxiong processed with wine can be used for treating menoxenia, amenorrhea, and dysmenorrhea by mixing with radix Angelicae sinensis;
frankincense: pungent and bitter in flavor and warm in nature; entering heart, liver and spleen meridians, they have the following actions: regulating qi, promoting blood circulation, relieving pain, and removing toxic materials; for treating stagnation of qi and blood, pain in heart and abdomen, carbuncle, sore, toxic swelling, traumatic injury, dysmenorrhea, and puerperal pain due to blood stasis; the vinegar processed frankincense is processed by rice vinegar, has better effect than frankincense, and has the functions of regulating qi, activating blood, relieving pain and dispelling toxin; can be used for treating stagnation of qi and blood, pain of heart and abdomen, carbuncle, sore, toxic swelling, traumatic injury, dysmenorrhea, and puerperal blood stasis and pain;
myrrh: bitter and pungent taste, neutral in nature, non-toxic, entering twelve meridians, and mainly functions: dissipating blood stasis, relieving swelling and alleviating pain; treating traumatic injury, incised wound, bone and muscle, pain of heart and abdomen, abdominal mass, amenorrhea, carbuncle, cellulitis, swelling and pain, anal fistula, and eye obstruction; the vinegar myrrh has the efficacies of promoting blood circulation, relieving pain, eliminating swelling, promoting granulation, protecting stomach function and the like, is very helpful for bronchitis, cough, bacterial infection and microbial infection, and can also lower blood pressure, blood fat and the like;
white atractylodes rhizome: bitter and sweet taste, warm nature; spleen and stomach meridians entered; the traditional Chinese medicine has the main functions of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, arresting sweating, preventing miscarriage, and is used for spleen deficiency and poor appetite, abdominal distension and diarrhea, phlegm and fluid retention and dizziness and palpitation, edema, spontaneous perspiration, threatened abortion, rhizoma atractylodis macrocephalae for strengthening spleen and stomach, preventing miscarriage, and for spleen deficiency and poor appetite, diarrhea and loose stool, threatened abortion; the fried bighead atractylodes rhizome has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage, and is mainly used for conditioning and treating the clinical symptoms of spleen deficiency and poor appetite, abdominal distension and diarrhea, phlegm and fluid retention and palpitation, edema and spontaneous perspiration, fetal irritability and the like in the body in clinical application; the parched Atractylodis rhizoma has effects of regulating stomach, invigorating qi, eliminating dampness and heat in spleen and stomach, invigorating spleen, promoting diuresis, relieving cough, resisting gastric ulcer, enhancing immunity, and correcting disorder of T cell group to improve immunity; the fried white atractylodes rhizome has the effects of resisting fatigue, enhancing the regulation of body hormone secretion, promoting urination and inhibiting uterine contraction, so the fried white atractylodes rhizome has the effect of preventing miscarriage; in addition, the composition can resist oxidation, delay aging, reduce blood sugar and resist tumors;
centipede: pungent and warm taste; is toxic; entering liver meridian; the functional indications are as follows: calming endogenous wind, relieving spasm, removing toxic substances, resolving hard mass, dredging collaterals, and relieving pain; it is used for treating apoplexy, epilepsy, tetanus, pertussis, scrofula, tuberculosis, tumor mass, pyocutaneous disease, toxic swelling, tinea, alopecia areata, anal fistula, scald, etc.; the raw centipedes are toxic, the raw centipedes have strong wind-dispelling and convulsion-relieving capability and are used for acute and chronic infantile convulsions, tetanus, epilepsy and the like, and the decoction of people is mostly used for raw; for external use, used for sore, ulcer, pyogenic infection, scrofula, fester, venomous snake bite, etc., the toxicity is reduced after baking, the taste is corrected and the odor is corrected, the dried and crisp are convenient to be crushed, and the medicines are taken in pills, powder or externally applied, and have the same functions as raw medicines;
leech: salty and bitter taste with mild nature; has little toxicity; entering liver meridian, the main actions are: breaking blood, removing stasis and restoring menstrual flow; treating abdominal mass, blood stasis, amenorrhea, and traumatic injury;
white muscardine silkworm: salty taste and neutral nature; entering liver, lung and stomach meridians; dispelling pathogenic wind, relieving spasm, eliminating phlegm, and resolving hard mass; for wind-stroke aphonia, fright epilepsy, headache and laryngeal wind; sore throat, scrofula and tuberculosis; urticaria, erysipelas, mastitis; the stir-fried stiff silkworm is a pungent and salty Chinese medicinal material with mild nature, can enter liver and lung channels, has important effects of dispelling wind and relieving spasm, reducing phlegm and resolving masses, can detoxify and relieve sore throat, and has good prevention and treatment effects on sore throat and hoarseness of human;
licorice root: sweet taste, mild nature, and can be used for invigorating spleen, replenishing qi, clearing away heat and toxic materials, eliminating phlegm, relieving cough, relieving spasm and pain, and harmonizing the medicines, and can be used for treating weakness of spleen and stomach, listlessness, debilitation, cardiopalmus, short breath, cough, excessive phlegm, abdominal cavity, limb spasm, pain, carbuncle, swelling, sore, and toxic materials, and relieving drug toxicity and strong nature;
achyranthes bidentata (achyranthes bidentata): has moderate property, sweet and slightly bitter taste, no toxicity, enters liver and kidney meridians, and has the main functions: unprocessed for dispersing blood stasis, dispersing swelling and dredging; treating gonorrhea, hematuria, amenorrhea, abdominal mass, dystocia, retained afterbirth, puerperal blood stasis and abdominal pain, pharyngitis, carbuncle and swelling, and traumatic injury; for cooking, liver nourishing and muscle and bone strengthening; treating lumbago, knee pain, spasm of limbs, and flaccidity and arthralgia;
nux vomica: cold in nature, bitter in taste, and toxic, entering liver and spleen meridians; the functional indications are as follows: externally applied, has the effects of dredging collaterals, relieving pain, resolving masses, relieving swelling, dispelling wind, eliminating dampness, strengthening tendons and bones, and can be used for treating rheumatism, numbness, paralysis and traumatic injury; carbuncle and cellulitis swelling and pain, rheumatoid arthritis, myasthenia gravis, facial paralysis, lumbar disc herniation, sciatic neuritis, epilepsy, aplastic anemia, poliomyelitis sequela, rheumatoid arthralgia, esophageal cancer, gastric cancer bone tumor, skin cancer and the like;
honey: sweet taste, mild nature, and alkaline food, and enters lung, spleen and large intestine meridians; the efficacy is as follows: mainly treating heart and abdomen pathogenic factors, arresting epilepsy, calming the five internal organs, tonifying qi, strengthening the middle-jiao, relieving pain, removing toxicity, and mixing with hundreds of medicines; nourishing spleen qi, relieving restlessness, eating and drinking failure, relieving pain in muscles and joints, aphtha, and improving eyesight and hearing.
The invention has the beneficial effects that: the ligusticum wallichii, the frankincense, the myrrh, the leech and the radix achyranthis bidentatae in the medicine can promote blood circulation to remove blood stasis, dredge collaterals to relieve pain, lower blood pressure and lower blood fat; scolopendra and Bombyx Batryticatus have effects of dispelling pathogenic wind, relieving pain, removing toxic substance and resolving hard mass; the white atractylodes rhizome, the honey and the liquorice can tonify qi, calm the nerves, moisten lung, relieve cough, improve sleep quality and improve human immunity; can be used for treating dizziness, headache, numbness of limbs, slurred speech, and hemiplegia caused by mild and moderate cerebral apoplexy, and has good therapeutic effect on arthritis caused by arthralgia due to wind-cold-dampness.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
a traditional Chinese medicine pill for treating cerebral apoplexy is composed of the following raw materials in parts by weight: 3 parts of angelica, 0.8 part of ligusticum chuanxiong hort, 2 parts of frankincense, 2.5 parts of myrrh, 3 parts of bighead atractylodes rhizome, 0.5 part of centipede, 0.1 part of leech, 1 part of white muscardine silkworm, 1 part of liquorice, 5 parts of achyranthes bidentata, 0.2 part of nux vomica and 20 parts of honey.
Example two:
a traditional Chinese medicine pill for treating cerebral apoplexy is composed of the following raw materials in parts by weight: 5 parts of angelica, 1 part of ligusticum chuanxiong hort, 3 parts of frankincense, 3 parts of myrrh, 5 parts of bighead atractylodes rhizome, 1 part of centipede, 0.2 part of leech, 1.5 parts of white muscardine silkworm, 2 parts of liquorice, 6 parts of achyranthes root, 0.3 part of nux vomica and 25 parts of honey.
Example three:
a traditional Chinese medicine pill for treating cerebral apoplexy is composed of the following raw materials in parts by weight: 5 parts of angelica, 1.3 parts of ligusticum chuanxiong hort, 3.5 parts of frankincense, 3.5 parts of myrrh, 5 parts of bighead atractylodes rhizome, 1 part of centipede, 0.3 part of leech, 2 parts of white muscardine silkworm, 2.5 parts of liquorice, 7 parts of achyranthes bidentata, 0.4 part of nux vomica and 30 parts of honey.
Example four:
a traditional Chinese medicine pill for treating cerebral apoplexy is composed of the following raw materials in parts by weight: 4 parts of angelica, 0.9 part of ligusticum chuanxiong hort, 2.5 parts of frankincense, 2.2 parts of myrrh, 4 parts of bighead atractylodes rhizome, 0.8 part of centipede, 0.2 part of leech, 1.3 parts of white muscardine silkworm, 1.5 parts of liquorice, 5.5 parts of achyranthes root, 0.3 part of nux vomica and 25 parts of honey.
A preparation method of the traditional Chinese medicine pill for treating cerebral apoplexy comprises the following steps:
step one, adding a certain amount of yellow wine into clean angelica slices, uniformly stirring, slightly moistening, putting the mixture into a stir-frying container after the wine is completely absorbed, heating the mixture by slow fire, stir-frying the mixture to be dark yellow, taking out the mixture, and cooling the mixture for later use, wherein 10kg of yellow wine is used for every 100kg of angelica slices;
step two, spraying the ligusticum wallichii slices with yellow wine uniformly, slightly stewing, frying in a pot until the temperature is slightly burnt, taking out and cooling for later use, wherein 50kg of the ligusticum wallichii slices are sprayed with 6.4kg of the yellow wine;
step three, taking clean frankincense, adding vinegar, uniformly stirring, stewing thoroughly, frying in a pot until the surface is bright, taking out, and cooling for later use, wherein 5kg of vinegar is used for every 100kg of frankincense;
step four, taking clean myrrh, adding vinegar, uniformly stirring, stewing thoroughly, frying in a pot until the surface is bright, taking out, cooling for later use, and adding 5kg of vinegar for every 100kg of myrrh;
step five, taking the clean white atractylodes rhizome slices, scattering the honey-fried bran into a hot pot, adding the white atractylodes rhizome slices when smoking, frying the white atractylodes rhizome slices until the white atractylodes rhizome slices are brown and the smell of the honey escapes, screening the honey-fried bran, taking out the honey-fried bran and cooling the honey-fried bran to obtain fried white atractylodes rhizome for later use, wherein 10kg of honey-fried bran is used for every 100kg of white atractylodes rhizome slices;
step six, taking the clean centipedes, removing heads and feet, placing the cleaned centipedes in a stir-frying container, baking the cleaned centipedes with slow fire until the black brown color is crisp, taking out the centipedes, and cooling the centipedes for later use;
step seven, scattering clean white muscardine silkworms into a hot pot by using bran, adding the white muscardine silkworms when smoke is emitted, frying to be yellow, taking out the white muscardine silkworms, screening off the bran, and cooling for later use, wherein 100kg of the white muscardine silkworms is used by 10kg of the bran;
step eight, taking clean nux vomica, scattering the clean nux vomica into a hot pot by using sand, adding the nux vomica when smoke is emitted, frying the nux vomica to brown yellow and swelling, screening out the sand, taking out and cooling the nux vomica for later use;
grinding the roasted Chinese angelica, the ligusticum chuanxiong hort processed with wine, the frankincense processed with vinegar, the myrrh processed with vinegar, the white atractylodes rhizome fried with bran, the fried centipede, the white muscardine silkworm fried with bran, the fried nux vomica, the leech, the liquorice and the achyranthes bidentata into powder, mixing the powder evenly, adding the honey and kneading the mixture into honeyed pills;
step ten, packaging the honeyed pills.
Preferably, in the eighth step, the stir-frying temperature of the nux vomica is 270-300 ℃.
Preferably, in the ninth step, the medicine is ground into powder and then screened by a 120-mesh pharmacopoeia sieve.
Preferably, in the ninth step, each honeyed pill is 3 g.
The application method of the invention is as follows: it is administered after meals for 3 times per day and 1 pill per time.
Note that: it is contraindicated for pregnant women, epilepsy patients, thrombocytopenia patients, and acute hemorrhage patients.
Acute oral toxicity test:
sample preparation: the traditional Chinese medicine pill for treating cerebral apoplexy is solid and is stored at normal temperature.
Experimental animals: 20 healthy adult SPF-grade ICR mice, each half of which is male and female, are provided by a pharmaceutical experimental animal center field of Nanjing medical university, and have the production license number of SCXK (Su) 2016-: 201933066. the experimental animals are raised in the central barrier system with the temperature of 20-26 ℃ and the relative humidity of 40-70%, and the experimental animals use license numbers: SYXK (Su) 2015-0009. Laboratory mouse maintenance feed (Co)60Irradiation) provided by cooperative pharmaceutical and bioengineering, llc of Jiangsu province, production licenses: suzuo Fed (2014) 01008.
The dosage selection and the administration mode of the test object are that according to the design requirement of the dosage of the limit method in the detection standard, the dosage is set to 10000 mg/kg. bw. for 3 days of animal quarantine, the weight of a female is 19.0-21.0 g, the weight of a male is 19.6-21.8 g during the test, the animal before the test is fasted for 4 hours, the animal freely drinks water, the test sample is prepared by adopting sterile water, the preparation concentration is 500mg/m L, the stomach filling and sample feeding are carried out for 1 time according to 20m L/kg.bw, the fasting is continued for 1-2 hours after the test, the poisoning performance and the death condition are recorded after the continuous observation for 14 days.
The results determine that no animal dies within the observation period following administration of the test subject, the subject is deemed to have an oral acute toxicity-resistant dose in an animal greater than a value at which L Dso is greater.
The experimental results are as follows: after the 20 ICR mice are administrated with self-made pills of 10000 mg/kg-bw by stomach filling, during the 14d experimental observation period, the animals have normal diet and activity, good growth, no toxic manifestation and abnormal physical sign and no animal death (see table 1).
To summarize: after 1000 mg/kg-bw self-made pill is orally administered to ICR mice, seeThe animal weight growth is not obviously abnormal, and no animal death occurs in the observation period, so the acute oral toxicity test L D of the male and male mice of the traditional Chinese medicine pill for treating cerebral apoplexy of the invention50More than 1000mg/kg bw.
Clinical cases:
1. the cases are as follows: the Chinese zodiac is a Chinese zodiac, a woman in 57 years old, a person in Shannan Shangshi county, a self-school, weak body and poor immune function, the brain neurasthenia is over when the person is 14 years old, the body is easy to be discomforted during the season change of spring and autumn, the person is easy to suffer from hypertension and hyperlipidemia along with the increase of age, the blood pressure and the blood fat are reduced and reduced, the pill is taken from 2017, the symptoms of dizziness and headache disappear, the triglyceride is reduced to 0.98 from 1.47, the blood pressure is recovered to be normal, and the symptoms of insomnia and dreaminess disappear.
2. The cases are as follows: when a certain plum is a woman in the age of 61 years and a person in Henan Luoning county is poor in physical quality, susceptible to cold and headache, the headache is not improved by searching medical questions at multiple places, the disease belongs to a confinement disease caused by the cold of a month through diagnosis, and the pill starts to be taken in 6 months in 2019, so that the headache symptom disappears after two months, the mental state is good, the physical quality is improved, and the immunity is enhanced.
3. The cases are as follows: one certain person, male, 62 years old, in Henan Luoning county, has a sunken wrist on the left hand, four stiff fingers on the left hand, cannot move, is diagnosed as muscular atrophy through a hospital, and is caused by wind-cold paralysis, the pill is taken in 6 months in 2019, the stiff finger symptoms basically disappear after thirty days of taking the pill, two fingers can freely move after sixty days of taking the pill, all four fingers recover to be normal after one hundred and fifty days of taking the pill, and the symptoms recover from the sunken wrist.
4. The cases are as follows: when a woman is in 71 years old and a person in the Henan consolidation market is in 2013, the hemiplegia symptom appears due to cerebral infarction caused by hypertension, hospitalization is not good, when the pill is taken in 2017 in 11 months, scalp itching appears after the pill is continuously taken for 15 days, the brain cells and capillary vessels have reaction, the cerebral hypoxia symptom disappears after the pill is taken for 20 days, the medicine is continuously taken, the second grade muscle force is recovered to the fifth grade, and the life can be self-managed.
5. The cases are as follows: in certain time, male, 64 years old, Shannan Shangshui county, 2014, who started to take the pill in 2018 in 3 months, normally walks normally and has powerful hands and feet after taking for four months because of cerebral infarction, general weakness and dizziness caused by hypertension.
6. The cases are as follows: when a certain woman is in 54 years old and a person in Henan Luoning county takes the pill in 2019, the person in 2014 suddenly suffers from cerebral hemorrhage, so that the hemiplegia, the walking difficulty, the talking is unclear, the toes cannot move, and the person starts to take the pill in 5 months, so that the toes feel movable after taking the pill for twenty days continuously, the person continuously takes the pill for three months, all the body aspects are improved, the body is strong, and the dizziness symptom disappears.
7. The cases are as follows: when a certain woman is in 83 years and a person in Henan Luoning county, because the wind-cold-dampness arthralgia causes swelling of the double knee joints, the pill disclosed by the invention is continuously taken for decades and 6 months in 2017, the pain is relieved after the pill is taken for twenty days, the swelling is reduced, the pill is continuously taken for thirty days, the swelling of the double knee joints is completely eliminated, the pain is eliminated, and the body is normal.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (9)
1. A traditional Chinese medicine pill for treating cerebral apoplexy is characterized in that: the composition is characterized by comprising the following raw materials in parts by weight: 3-5 parts of angelica, 0.8-1.3 parts of ligusticum chuanxiong hort, 2-3.5 parts of frankincense, 2.5-3.5 parts of myrrh, 3-5 parts of bighead atractylodes rhizome, 0.5-1 part of centipede, 0.1-0.3 part of leech, 1-2 parts of white muscardine silkworm, 1-2.5 parts of liquorice, 5-7 parts of achyranthes bidentata, 0.2-0.4 part of nux vomica and 20-30 parts of honey.
2. The traditional Chinese medicine pill for treating cerebral apoplexy according to claim 1, wherein: the composition is characterized by comprising the following raw materials in parts by weight: 3 parts of angelica, 0.8 part of ligusticum chuanxiong hort, 2 parts of frankincense, 2.5 parts of myrrh, 3 parts of bighead atractylodes rhizome, 0.5 part of centipede, 0.1 part of leech, 1 part of white muscardine silkworm, 1 part of liquorice, 5 parts of achyranthes bidentata, 0.2 part of nux vomica and 20 parts of honey.
3. The traditional Chinese medicine pill for treating cerebral apoplexy according to claim 1, wherein: the composition is characterized by comprising the following raw materials in parts by weight: 5 parts of angelica, 1 part of ligusticum chuanxiong hort, 3 parts of frankincense, 3 parts of myrrh, 5 parts of bighead atractylodes rhizome, 1 part of centipede, 0.2 part of leech, 1.5 parts of white muscardine silkworm, 2 parts of liquorice, 6 parts of achyranthes root, 0.3 part of nux vomica and 25 parts of honey.
4. The traditional Chinese medicine pill for treating cerebral apoplexy according to claim 1, wherein: the composition is characterized by comprising the following raw materials in parts by weight: 5 parts of angelica, 1.3 parts of ligusticum chuanxiong hort, 3.5 parts of frankincense, 3.5 parts of myrrh, 5 parts of bighead atractylodes rhizome, 1 part of centipede, 0.3 part of leech, 2 parts of white muscardine silkworm, 2.5 parts of liquorice, 7 parts of achyranthes bidentata, 0.4 part of nux vomica and 30 parts of honey.
5. The traditional Chinese medicine pill for treating cerebral apoplexy according to claim 1, wherein: the composition is characterized by comprising the following raw materials in parts by weight: 4 parts of angelica, 0.9 part of ligusticum chuanxiong hort, 2.5 parts of frankincense, 2.2 parts of myrrh, 4 parts of bighead atractylodes rhizome, 0.8 part of centipede, 0.2 part of leech, 1.3 parts of white muscardine silkworm, 1.5 parts of liquorice, 5.5 parts of achyranthes root, 0.3 part of nux vomica and 25 parts of honey.
6. The preparation method of the traditional Chinese medicine pill for treating cerebral apoplexy according to any one of claims 1-5, is characterized in that: the method comprises the following steps:
step one, adding a certain amount of yellow wine into clean angelica slices, uniformly stirring, slightly moistening, putting the mixture into a stir-frying container after the wine is completely absorbed, heating the mixture by slow fire, stir-frying the mixture to be dark yellow, taking out the mixture, and cooling the mixture for later use, wherein 10kg of yellow wine is used for every 100kg of angelica slices;
step two, spraying the ligusticum wallichii slices with yellow wine uniformly, slightly stewing, frying in a pot until the temperature is slightly burnt, taking out and cooling for later use, wherein 50kg of the ligusticum wallichii slices are sprayed with 6.4kg of the yellow wine;
step three, taking clean frankincense, adding vinegar, uniformly stirring, stewing thoroughly, frying in a pot until the surface is bright, taking out, and cooling for later use, wherein 5kg of vinegar is used for every 100kg of frankincense;
step four, taking clean myrrh, adding vinegar, uniformly stirring, stewing thoroughly, frying in a pot until the surface is bright, taking out, cooling for later use, and adding 5kg of vinegar for every 100kg of myrrh;
step five, taking the clean white atractylodes rhizome slices, scattering the honey-fried bran into a hot pot, adding the white atractylodes rhizome slices when smoking, frying the white atractylodes rhizome slices until the white atractylodes rhizome slices are brown and the smell of the honey escapes, screening the honey-fried bran, taking out the honey-fried bran and cooling the honey-fried bran to obtain fried white atractylodes rhizome for later use, wherein 10kg of honey-fried bran is used for every 100kg of white atractylodes rhizome slices;
step six, taking the clean centipedes, removing heads and feet, placing the cleaned centipedes in a stir-frying container, baking the cleaned centipedes with slow fire until the black brown color is crisp, taking out the centipedes, and cooling the centipedes for later use;
step seven, scattering clean white muscardine silkworms into a hot pot by using bran, adding the white muscardine silkworms when smoke is emitted, frying to be yellow, taking out the white muscardine silkworms, screening off the bran, and cooling for later use, wherein 100kg of the white muscardine silkworms is used by 10kg of the bran;
step eight, taking clean nux vomica, scattering the clean nux vomica into a hot pot by using sand, adding the nux vomica when smoke is emitted, frying the nux vomica to brown yellow and swelling, screening out the sand, taking out and cooling the nux vomica for later use;
grinding the roasted Chinese angelica, the ligusticum chuanxiong hort processed with wine, the frankincense processed with vinegar, the myrrh processed with vinegar, the white atractylodes rhizome fried with bran, the fried centipede, the white muscardine silkworm fried with bran, the fried nux vomica, the leech, the liquorice and the achyranthes bidentata into powder, mixing the powder evenly, adding the honey and kneading the mixture into honeyed pills;
step ten, packaging the honeyed pills.
7. The preparation method of the traditional Chinese medicine pill for treating cerebral apoplexy according to claim 6, wherein the preparation method comprises the following steps: in the eighth step, the stir-frying temperature of the nux vomica is 270-300 ℃.
8. The preparation method of the traditional Chinese medicine pill for treating cerebral apoplexy according to claim 6, wherein the preparation method comprises the following steps: in the ninth step, the medicine is ground into powder and then screened by a 120-mesh pharmacopeia sieve.
9. The preparation method of the traditional Chinese medicine pill for treating cerebral apoplexy according to claim 6, wherein the preparation method comprises the following steps: in the ninth step, each honeyed pill is 3 g.
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CN1628785A (en) * | 2004-09-28 | 2005-06-22 | 姜奎祥 | Quick acting Chinese medicine for dissolving thrombolysis and dredging collaterals and its preparation method |
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