CN111466398A - Thiophanate-methyl compound bactericide and application thereof - Google Patents

Thiophanate-methyl compound bactericide and application thereof Download PDF

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CN111466398A
CN111466398A CN202010471613.9A CN202010471613A CN111466398A CN 111466398 A CN111466398 A CN 111466398A CN 202010471613 A CN202010471613 A CN 202010471613A CN 111466398 A CN111466398 A CN 111466398A
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thiophanate
methyl
compound bactericide
berberine
bactericide
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田平芳
刘金蓉
葛喜珍
赵鹏
刘国新
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Beijing University of Chemical Technology
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

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  • Agronomy & Crop Science (AREA)
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Abstract

The invention discloses thiophanate methyl compound bactericide and application thereof. The compound bactericide comprises thiophanate-methyl and berberine, and the balance of auxiliary agents; wherein, the content of the thiophanate-methyl is 30 to 60 percent by weight percent, and the weight ratio of the berberine to the thiophanate-methyl is 1: 29 to 119. The compound bactericide is used for preventing and treating crop fungal diseases, in particular brown rot of peach. The compound bactericide of the invention takes thiophanate-methyl as a main component, and berberine is added as a synergist, so that the control effect of the thiophanate-methyl can be obviously improved, the compound bactericide has both protection and treatment effects, can effectively prevent and treat the brown rot of peach, and is safe to non-target organisms and environment.

Description

Thiophanate-methyl compound bactericide and application thereof
Technical Field
The invention relates to a thiophanate-methyl compound bactericide and application thereof, belonging to the field of agriculture and chemical industry.
Background
The wide application of chemical pesticide plays a great role in ensuring the high and stable yield of crops. However, the long-term large-scale unreasonable use of traditional chemical pesticides causes the problem of '3R', namely, the residue, resistance and rampant are gradually and seriously, which causes general social attention. The search and development of novel pesticides that are safe to human health and ecological environment is imminent. From 2015, the Ministry of agriculture formally starts the action of reducing weight and reducing pesticide, so as to realize zero increase of the use amount of chemical fertilizers and pesticides of crops. The reduction of the using amount of the pesticide and the improvement of the control effect are one of the effective methods for solving the zero growth of the pesticide.
Thiophanate-methyl is a high-efficiency and low-toxicity fungicide, has the functions of prevention and systemic absorption, and can be converted into carbendazim after entering a plant body. The thiophanate methyl has wide sterilization range and good systemic property, can be quickly absorbed by plant leaves and root systems, is conducted in vivo and uniformly distributed, and mainly inhibits the demethylation of sterol in pathogenic fungi to block the formation of a biological membrane, thereby causing the death of pathogenic bacteria. The thiophanate methyl has obvious control effects on alternaria leaf spot, powdery mildew, brown spot, brown wheel spot, grape gray mold, root rot, wheat mildew and the like.
Berberine is quaternary amine isoquinoline alkaloid mainly contained in Coptidis rhizoma, Phellodendri cortex of Rutaceae, and Berberis of berberidaceae. Researches prove that the berberine has better control effect on a plurality of diseases such as apple ring spot, peach brown rot, powdery mildew, gray mold, downy mildew and the like; indoor bioassay and field pesticide effect measurement results show that berberine has good control effects on powdery mildew, angular leaf spot, leaf mold, ring spot, phytophthora root rot and the like.
According to data retrieval, the patent documents related to compounding with thiophanate-methyl currently comprise: for example, patent document CN102885067A discloses a prochloraz-carbendazim wettable powder bactericide and a production process thereof, wherein the bactericide comprises prochloraz and carbendazim; patent document CN102907449A discloses a bactericidal composition containing epoxiconazole and carbendazim and application thereof, wherein the effective components of the bactericidal composition comprise epoxiconazole and carbendazim; patent document CN105766959A discloses a bactericidal composition containing isopyrazam and carbendazim and application thereof, wherein the bactericidal composition takes isopyrazam and carbendazim as main active ingredients; patent document CN1947509 discloses a propiconazole-carbendazim compound bactericide, which is prepared by compounding propiconazole and carbendazim; patent document CN1947510 discloses a bactericidal composition containing tebuconazole and carbendazim, which consists of tebuconazole and carbendazim; patent document CN1957703 discloses a kresoxim-methyl and carbendazim mixed microemulsion and a preparation method thereof, wherein the microemulsion utilizes the synergistic effect of the kresoxim-methyl and the carbendazim. The above patent documents mostly disclose combinations of several chemical pesticides. Patent document CN105076232A discloses a bactericidal composition containing carbendazim and a pinnatifida extract, which contains effective components of carbendazim and the pinnatifida extract; but the patent and application of berberine to improve the control effect of thiophanate-methyl are not found.
The patent documents of berberine as agricultural fungicide mainly include: patent document CN103975962A discloses a wettable powder for preventing and treating fruit and vegetable brown rot and aphid and a preparation method thereof, wherein the effective components of the wettable powder are szechwan chinaberry fruit extract and berberine; patent document CN103814916A discloses berberine pesticide and its preparation method, the formulation comprises berberine and matrine; patent document CN103548849A discloses a synergistic botanical fungicide consisting of eugenol and berberine; patent document CN103503919A discloses a high adhesion jujube fruit shrink disease emulsion comprising active ingredients (streptomycin, instant boron, berberine), adhesive (chitosan, sodium carboxymethylcellulose CMC-NA-glycerol) and emulsifier (tween 80); patent document CN103444729A discloses a bactericidal pharmaceutical composition and its application, the bactericidal pharmaceutical composition includes two active ingredients: berberine and amino-oligosaccharins; patent document CN102940000A discloses botanical broad-spectrum bactericide comprising berberine, astragalus polysaccharides, radix tetrastigme extract, aloe extract, and fructus Gleditsiae Abnormalis; patent document CN102894002A discloses a compound bactericide consisting of berberine and polyoxin; the compound algistat disclosed in patent document CN102771484A mainly contains berberine and artemisinin; patent document CN102119703A discloses a botanical fungicide composed of rhubarb, rosin, aloe, berberine, Chinese honeylocust fruit and chinaberry root; two effective components of the botanical fungicide disclosed in patent document CN101961019A are berberine and osthole; the raw materials of berberine botanical insecticide disclosed in patent document CN101940229A relate to barberry root, phellodendron bark, perilla, castor bean; the active ingredients of the microemulsion for killing Monilinia fructicola disclosed in patent document CN101695301A are berberine and salicylic acid; patent document CN101574083A discloses sustained-release microcapsules and composite membranes for inhibiting monilinia fructicola, which mainly comprise chitosan and berberine. The patent document CN 104488923B discloses a botanical synergistic compound bactericide which uses berberine and physcion as main components. The research of the berberine used as the synergist for improving the drug effect of thiophanate-methyl has not been reported.
In conclusion, the patent, literature and product related to the improvement of the control of crop diseases and insect pests by thiophanate-methyl by berberine are not disclosed and reported.
Based on the technologies, the invention is funded by ' 2019 Hebei province key research and development plan project-special item of agricultural high-quality development key commonness technology attack and customs (project number 19226509D) ' 2018 Beijing Union university talent reinforced school preferred plan '.
Disclosure of Invention
The invention aims to provide the thiophanate-methyl compound bactericide, the synergist is added into the thiophanate-methyl compound bactericide, the control effect of the thiophanate-methyl can be obviously improved, the thiophanate-methyl compound bactericide has protection and treatment effects, the brown rot of peaches can be effectively prevented and treated, and the thiophanate-methyl compound bactericide is safe to non-target organisms and the environment.
The invention also aims to provide application of the thiophanate methyl compound bactericide in the aspect of preventing and treating fungal diseases of crops.
In order to achieve the purpose, the invention adopts the following technical scheme:
a thiophanate-methyl compound bactericide comprises thiophanate-methyl and berberine, and the balance of auxiliary agents; wherein, the content of the thiophanate-methyl is 30 to 60 percent by weight percent, and the weight ratio of the berberine to the thiophanate-methyl is 1: 29 to 119.
The preparation form of the compound bactericide is liquid or solid, and can be soluble liquid, aqueous solution, missible oil, suspending agent, powder, granules or wettable powder, for example.
As a soluble liquid agent, the auxiliary agent comprises: surfactant, emulsifier and organic solvent, wherein the soluble liquid contains 5-15 wt% of surfactant and 5-20 wt% of emulsifier. The surfactant and emulsifier are respectively selected from one or more of alkyl benzene sulfonate, alkylphenol polyoxyethylene ether, phenethyl phenol polyoxyethylene ether polyoxypropylene ether, castor oil and ethylene oxide adduct or aralkyl phenol polyoxyethylene ether formaldehyde condensate.
The production method of the soluble liquid agent comprises the following steps: weighing the raw materials according to a formula, sequentially adding the raw materials into the reaction kettle, mixing the raw materials, stirring the mixture in the reaction kettle to be transparent, and carrying out quality inspection to obtain a finished product.
As wettable powder, the auxiliary agent comprises: a carrier and a dispersant. The carrier is one or more of bentonite, activated clay, kaolin or attapulgite clay; the dispersant is one or more of Poloxamer188, glyceryl monostearate (Gelucire), sodium dodecyl benzene sulfonate and calcium dodecyl benzene sulfonate.
The production method of the wettable powder comprises the following steps: weighing raw materials according to a formula, sequentially adding and mixing, crushing in an ultrafine crusher, sieving by a 200-mesh sieve, and performing quality inspection to obtain a finished product.
The application of the thiophanate methyl compound bactericide is used for preventing and treating fungal diseases of crops. Preferably, the fungal disease is brown rot of peach.
The invention has the advantages that:
the compound bactericide of the invention takes thiophanate-methyl as a main component, and berberine is added as a synergist, so that the control effect of the thiophanate-methyl can be obviously improved, the compound bactericide has both protection and treatment effects, can effectively prevent and treat the brown rot of peach, and is safe to non-target organisms and environment.
1. The berberine is a natural active substance, is easy to degrade in the environment, has low toxicity to mammals such as human and livestock, is safe to natural enemies of pests and other beneficial organisms, and is not easy to generate drug resistance by pathogenic bacteria. The berberine serving as a synergist enhances the prevention and treatment effects of the berberine in cooperation with thiophanate-methyl by enhancing or inducing plant immunity.
2. The content of thiophanate-methyl in the compound bactericide is 30-60%, and the ratio of berberine to thiophanate-methyl is 1: 29-119, so that the control effect of thiophanate-methyl can be improved by above 15%. The control effect of thiophanate-methyl can be obviously improved by adding a small amount of berberine, thereby reducing the dosage of thiophanate-methyl.
3. The invention utilizes berberine which has antibacterial and immunoregulatory effects to play a role in health care of crops, so that the crops grow strongly and diseases are obviously reduced.
Drawings
FIG. 1 is a diagram showing the effect of thiophanate methyl and berberine on the inhibition of Monilinia fructicola.
FIG. 2 is a diagram showing the effect of berberine and thiophanate-methyl in inhibiting Monilinia fructicola.
Detailed Description
The present invention is further illustrated by the following specific examples. The invention will be better understood from the following examples. However, those skilled in the art will readily appreciate that the specific material ratios, process conditions and results thereof described in the examples are illustrative only and should not be taken as limiting the invention as detailed in the claims.
Toxicity determination of thiophanate methyl and berberine on monilinia persicae
Monilinia fructicola (Monilinia fructicola) is a gift given by the Kudzuvine professor of Beijing Union university. 98% berberine (BBR) is purchased from Shaanxi Huiyike biological development Co., Ltd. The 70% thiophanate-methyl wettable powder is purchased from agriculture chemical products of Guangxi, Anhui, Inc.
Selecting Monilinia fructicola (Botrytis fructicola) growing on a solid PDA culture medium for 5 days, punching a bacterial cake on the surface of a bacterial colony by using a puncher with the diameter of 8mm, inoculating hypha downwards to the standby PDA culture medium, culturing for 48h in a constant-temperature incubator at 28 ℃, measuring the diameter of an inhibition zone by adopting a cross method every 24h, calculating an inhibition rate, converting the inhibition rate into a mechanical rate value according to an inhibition rate mechanical rate value conversion table, drawing a standard curve by taking the logarithm of the concentration of a medicament as a horizontal coordinate and the mechanical rate as a vertical coordinate to obtain a virulence regression equation and a correlation coefficient, and calculating the half-maximum effect according to the virulence regression equationConcentration (EC)50)。
The inhibition effects of berberine and thiophanate-methyl on Monilinia fructicola are respectively examined according to the methods. PDA medium without agent was used as a blank (CK) control, with three replicates per agent concentration setting. The inhibition of thiophanate methyl and berberine on the mycelial growth of Monilinia fructicola at 120h is shown in tables 1 and 2 below. The visual observation condition is shown in figure 1, wherein A shows the inhibition effect of berberine on Monilinia fructicola; c shows the inhibition effect of thiophanate methyl on Monilinia fructicola. Taking the logarithm of the concentration of the medicament as an abscissa and the rate of inhibition probability as an ordinate, drawing a standard curve to obtain a toxicity regression equation and related coefficients, and calculating the toxicity (EC) of various medicaments on the Monilinia fructicola according to the toxicity regression equation50Value, EC of berberine and thiophanate-methyl for inhibiting Monilinia fructicola50The values were 8. mu.g/m L and 0.59. mu.g/m L, respectively.
TABLE 1 Berberine inhibition of mycelial growth of Monilinia fructicola (120h)
Figure BDA0002512748670000041
TABLE 2 inhibitory effect of thiophanate methyl on mycelial growth of Monilinia fructicola in peach (120h)
Figure BDA0002512748670000051
Synergistic effect of berberine on inhibition of monilinia fructicola by thiophanate methyl
The co-toxicity factor method is the most common method for evaluating the compounding effect. The co-toxicity factor method firstly designs a series of ratios, and then calculates the co-toxicity factors under each ratio to evaluate the effect.
The co-virulence factor (CTF) was calculated according to formula 1.
A
In the formula:
h0-theoretical inhibition rate of the combination agent;
h1-actual inhibition ratio of the combination;
∑ -co-virulence factors.
If ∑ is more than 20, the two single agents are compounded to generate a synergistic effect;
if ∑ is less than-20, it shows that the two single agents are compounded to generate antagonism;
if-20 < ∑ < 20, it means that the two single agents are compounded to produce additive effect.
According to a co-toxicity factor method, the additive amount of thiophanate methyl is a, the additive amount of berberine is b, the dosing culture medium is prepared according to a compounding ratio that a: b is 99: 21, 110: 10, 116: 4, 117: 3 and 119: 1 respectively, PDA culture medium without medicament is used as blank (CK) contrast, three parallel agents are arranged in each compounding ratio, then the Monilinia fructicola (Botrytis) which is punched by a puncher with the diameter of 8mm is inoculated to the center of the culture medium in a mode that hyphae faces downwards, after 48h of culture at 28 ℃, the diameter of a bacteriostatic circle is measured by adopting a cross method every 24 h. The inhibition of the growth of Monilinia fructicola hyphae by compounding berberine and thiophanate-methyl at 120h is shown in Table 3, and the visual observation is shown in FIG. 2.
TABLE 3 inhibitory effect of berberine and thiophanate-methyl on mycelial growth of Monilinia fructicola (120h)
Figure BDA0002512748670000052
And calculating the actual inhibition rate of the compound agent, calculating the theoretical inhibition rate of the compound agent according to a toxicity regression equation, calculating the co-toxicity factor according to the formula 1, and evaluating the antibacterial effect of the compound agent.
The interaction of the single agents is different, so that the compound agent has additive, antagonistic or synergistic effect on pathogenic bacteria, berberine produces synergistic effect on thiophanate-methyl as shown in figure 2, wherein ① CK, ② a: b: 99: 21, ③ a: b: 110: 10, ④ a: b: 116: 4, for additive effect, ⑤ a: b: 117: 3, for additive effect, ⑥ a: b: 119: 1, for synergistic effect, and the specific data result is shown in table 4.
TABLE 4 evaluation of the efficacy of berberine and thiophanate-methyl on Monilinia fructicola
Compounding ratio H0(％) H1(％) ∑ Effect
99∶21 57.9 50.6 -12.6 Adding
110∶10 65.5 59.0 -9.9 Adding
116∶4 69.5 60.3 -13.2 Adding
117∶3 69.9 67.9 -2.9 Adding
119∶1 65.8 79.3 20.5 Synergistic effect
Example 1
At room temperature, 50 parts of thiophanate methyl and 1 part of berberine are taken, 10 parts of sodium dodecyl benzene sulfonate (dispersant) is added, and 100 parts of bentonite is used for supplementing. Pulverizing in a superfine pulverizer, and sieving with 200 mesh sieve to obtain 50% thiophanate methyl wettable powder.
Example 2
At room temperature, 30 parts of thiophanate-methyl and 1 part of berberine are taken, 10 parts of calcium dodecyl benzene sulfonate (dispersant) is added, and activated clay is used for supplementing to 100 parts. Pulverizing in a superfine pulverizer, and sieving with 200 mesh sieve to obtain 30% thiophanate methyl wettable powder.
Comparative example 1
At room temperature, 50 parts of thiophanate-methyl is taken according to the parts by weight, no berberine is added, 10 parts of sodium dodecyl benzene sulfonate (dispersing agent) is added, and 100 parts of bentonite is used for supplementing. Pulverizing in a superfine pulverizer, and sieving with 200 mesh sieve to obtain 50% thiophanate methyl wettable powder.
Example 3
At room temperature, 60 parts by weight of thiophanate-methyl is taken, 0.6 part of berberine is added, and 10 parts of sodium dodecyl benzene sulfonate and 10 parts of phenethyl phenol polyoxyethylene ether are sequentially added. Make up to 100 parts with dimethylformamide. Stirring the mixture in a reaction kettle at the stirring speed of 200 revolutions per minute for 70 minutes, and stirring the mixture for transparency to obtain 60 percent thiophanate methyl soluble liquid.
Example 4
At room temperature, 40 parts by weight of thiophanate-methyl is taken, 1 part of berberine is added, and 10 parts of calcium dodecyl benzene sulfonate and 8 parts of castor oil emulsifier are sequentially added. Make up to 100 parts with dimethylformamide. Stirring the mixture in a reaction kettle at the stirring speed of 200 rpm for 70 minutes, and stirring the mixture for transparency to obtain 40 percent thiophanate methyl soluble liquid.
Comparative example 2
At room temperature, 60 parts of thiophanate-methyl is taken according to parts by weight, no berberine is added, 10 parts of sodium dodecyl benzene sulfonate and 10 parts of phenethyl phenol polyoxyethylene ether as an emulsifier are sequentially added. Make up to 100 parts with dimethylformamide. Stirring the mixture in a reaction kettle at a stirring speed of 200 revolutions per minute for 70 minutes until the mixture is transparent, thus obtaining 60 percent thiophanate methyl soluble liquid.
Comparative example 3
At room temperature, 30 parts by weight of berberine is taken, 10 parts by weight of sodium dodecyl benzene sulfonate (dispersant) is added, and 100 parts by weight of bentonite is used for supplementing. Pulverizing in a superfine pulverizer, and sieving with 200 mesh sieve to obtain 30% berberine wettable powder.
The field efficacy test of each example on peach brown rot
In order to determine the field efficacy situation of the embodiment of the invention, the pesticide of the embodiment is subjected to field plot pesticide effect test of peach brown rot in a Beijing valley region in 2018, the plot test is randomly arranged and repeated for 3 times, 10 plants/plot are adopted, the dosage of the reagent is 75mg a.i./L, the pesticide is sprayed for 6 times, clear water blank control is set, the harvesting of the peaches is carried out in 20 days in 7 months, 5 peaches are treated in each test, branches in four directions of east, west, south and north of the peaches are selected, 200 fruits are investigated, the incidence and healthy fruit number of the brown rot are recorded, the incidence situation of the brown rot is calculated, once the brown rot occurs in the fruits, the sales of the fruits are influenced, the economic value is lost, and the control effect is expressed by the following formula.
Disease fruit rate (%) (investigation of disease fruit number/investigation of total fruit number) × 100
Control effect (%) [ (blank control area fruit disease rate-treatment area fruit disease rate)/blank control area fruit disease rate ] × 100
Test results and statistics: the field control effect of the above examples and comparative examples on brown rot of peach was performed by the conventional spraying method, and the results are shown in table 5.
TABLE 5 control of peach brown rot in each example
Figure BDA0002512748670000071
As can be seen from Table 5, the bactericide compounded by thiophanate methyl and berberine serving as a synergist (examples 1, 2, 3 and 4) has the control effect on the peach brown rot of 85.02-91.26%, and has a significant difference in control effect compared with 69.21-71.86% of a control medicament (comparative examples 1 and 2 without berberine serving as a synergist). The berberine can improve the control effect of thiophanate-methyl by more than 15 percent. In addition, berberine is an effective component in Chinese traditional medicines of rhizoma Coptidis and cortex Phellodendri, is a natural product, and is easily degradable in environment. The use of trace berberine can obviously improve the control effect of thiophanate-methyl, reduce the cost and is friendly to non-target organisms and environment.

Claims (9)

1. The thiophanate-methyl compound bactericide is characterized by comprising thiophanate-methyl and berberine, and the balance of auxiliaries; wherein, the content of the thiophanate-methyl is 30 to 60 percent by weight percent, and the weight ratio of the berberine to the thiophanate-methyl is 1: 29 to 119.
2. The thiophanate methyl compound bactericide as claimed in claim 1, characterized in that the form of the compound bactericide is liquid or solid.
3. The thiophanate methyl compound bactericide as claimed in claim 2, characterized in that the dosage form of the compound bactericide is soluble liquid, aqueous agent, emulsifiable solution, suspending agent, powder, granule or wettable powder.
4. The thiophanate methyl compound bactericide as claimed in claim 3, wherein the formulation of the compound bactericide is soluble liquid, and the auxiliary agent comprises: surfactant, emulsifier and organic solvent, wherein the soluble liquid contains 5-15 wt% of surfactant and 5-20 wt% of emulsifier.
5. The thiophanate methyl compounded bactericide as claimed in claim 4, wherein the surfactant and emulsifier are respectively selected from one or more of alkyl benzene sulfonates, alkylphenol ethoxylates, phenethylphenol ethoxylates polyoxypropylene ethers, castor oil and ethylene oxide adducts or aralkylphenol polyoxyethylene ether formaldehyde condensates.
6. The thiophanate methyl compound bactericide as claimed in claim 3, characterized in that the formulation of the compound bactericide is wettable powder, and the auxiliary agent comprises: a carrier and a dispersant.
7. The thiophanate methyl compound bactericide as claimed in claim 6, characterized in that the carrier is one or more of bentonite, activated clay, kaolin or attapulgite clay; the dispersant is one or more of Poloxamer188, glyceryl monostearate, sodium dodecyl benzene sulfonate and calcium dodecyl benzene sulfonate.
8. The application of the thiophanate methyl compound bactericide as defined in any one of claims 1 to 7 is used for controlling crop fungal diseases.
9. Use according to claim 8, characterized in that the fungal disease is brown rot of peach.
CN202010471613.9A 2020-05-28 2020-05-28 Thiophanate-methyl compound bactericide and application thereof Pending CN111466398A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110547298A (en) * 2018-06-04 2019-12-10 中国农业大学 Application of berberine as bactericidal synergist in prevention and treatment of plant gray mold

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110547298A (en) * 2018-06-04 2019-12-10 中国农业大学 Application of berberine as bactericidal synergist in prevention and treatment of plant gray mold

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