CN111465857A - 诊断早期心力衰竭的方法 - Google Patents
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- CN111465857A CN111465857A CN201880063136.3A CN201880063136A CN111465857A CN 111465857 A CN111465857 A CN 111465857A CN 201880063136 A CN201880063136 A CN 201880063136A CN 111465857 A CN111465857 A CN 111465857A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017903138 | 2017-08-08 | ||
| AU2017903138A AU2017903138A0 (en) | 2017-08-08 | Methods for Diagnosis of Early Stage Heart Failure | |
| PCT/AU2018/050827 WO2019028507A1 (en) | 2017-08-08 | 2018-08-08 | METHODS OF DIAGNOSING PRECOCUS STAGES OF CARDIAC INSUFFICIENCY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111465857A true CN111465857A (zh) | 2020-07-28 |
Family
ID=65273054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880063136.3A Pending CN111465857A (zh) | 2017-08-08 | 2018-08-08 | 诊断早期心力衰竭的方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20200174021A1 (https=) |
| EP (1) | EP3665483A4 (https=) |
| JP (1) | JP7414281B2 (https=) |
| CN (1) | CN111465857A (https=) |
| AU (2) | AU2018315056B2 (https=) |
| WO (1) | WO2019028507A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024007778A1 (zh) * | 2022-07-05 | 2024-01-11 | 上海交通大学医学院附属上海儿童医学中心 | 一种血浆分子标志物犬尿氨酸在早期心力衰竭检测中的应用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021245459A1 (en) * | 2020-06-03 | 2021-12-09 | Esn Cleer | Biomarker identification for imminent and/or impending heart failure |
| EP4356142A4 (en) | 2021-06-16 | 2025-07-23 | Endothelium Scanning Nanotechnology Ltd | BIOMARKERS AND DRUG COMBINATIONS FOR THE PREDICTION OF HEART FAILURE |
Citations (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002061131A2 (en) * | 2000-12-04 | 2002-08-08 | Bristol-Myers Squibb Company | Human single nucleotide polymorphisms |
| WO2002094870A2 (en) * | 2000-11-02 | 2002-11-28 | Curagen Corporation | Proteins and nucleic acids encoding same |
| US20040033582A1 (en) * | 2002-06-03 | 2004-02-19 | Manling-Ma Edmonds | Human single nucleotide polymorphisms |
| CN1703523A (zh) * | 2002-09-30 | 2005-11-30 | 肿瘤疗法科学股份有限公司 | 诊断前列腺癌的方法 |
| WO2006008002A2 (en) * | 2004-07-23 | 2006-01-26 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with kallikrein 1 (klk1) |
| CN101031640A (zh) * | 2004-07-29 | 2007-09-05 | 干细胞创新有限公司 | 干细胞的分化 |
| WO2008000067A1 (en) * | 2006-06-26 | 2008-01-03 | Vasogen Ireland Limited | Treatment of mild chronic heart failure in human patients |
| US20080057590A1 (en) * | 2006-06-07 | 2008-03-06 | Mickey Urdea | Markers associated with arteriovascular events and methods of use thereof |
| US20080300170A1 (en) * | 2006-09-01 | 2008-12-04 | Cohava Gelber | Compositions and methods for diagnosis and treatment for type 2 diabetes |
| CN101340928A (zh) * | 2005-10-21 | 2009-01-07 | 催化剂生物科学公司 | 抑制补体激活的修饰的蛋白酶 |
| CN101517074A (zh) * | 2006-07-05 | 2009-08-26 | 催化剂生物科学公司 | 蛋白酶筛选方法及由此鉴别的蛋白酶 |
| CN101617227A (zh) * | 2006-11-30 | 2009-12-30 | 纳维哲尼克斯公司 | 遗传分析系统和方法 |
| US20100267052A1 (en) * | 2006-09-01 | 2010-10-21 | American Type Culture Collection | Compositions and methods for diagnosis and treatment of type 2 diabetes |
| US20120219943A1 (en) * | 2011-02-03 | 2012-08-30 | Abbott Laboratories | Methods of prognosis and diagnosis in chronic heart failure |
| CN102858985A (zh) * | 2009-07-24 | 2013-01-02 | 西格马-奥尔德里奇有限责任公司 | 基因组编辑方法 |
| US20130116343A1 (en) * | 2010-04-21 | 2013-05-09 | Board Of Regents Of The University Of Texas System | Salivary Protein Markers for Detection of Breast Cancer |
| CN103289980A (zh) * | 2006-07-05 | 2013-09-11 | 催化剂生物科学公司 | 蛋白酶筛选方法及由此鉴别的蛋白酶 |
| CN103642902A (zh) * | 2006-11-30 | 2014-03-19 | 纳维哲尼克斯公司 | 遗传分析系统和方法 |
| WO2014193999A2 (en) * | 2013-05-28 | 2014-12-04 | Caris Science, Inc. | Biomarker methods and compositions |
| US20150291966A1 (en) * | 2012-07-25 | 2015-10-15 | The Broad Institute, Inc. | Inducible dna binding proteins and genome perturbation tools and applications thereof |
| WO2016134365A1 (en) * | 2015-02-20 | 2016-08-25 | The Johns Hopkins University | Biomarkers of myocardial injury |
| US20170051053A1 (en) * | 2011-12-28 | 2017-02-23 | Immunoqure Ag | Method of providing monoclonal auto-antibodies with desired specificity |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005110602A (ja) * | 2003-10-09 | 2005-04-28 | Sumitomo Pharmaceut Co Ltd | アトピー性皮膚炎の疾患マーカー及びその利用 |
| EP1722232A1 (en) * | 2005-05-09 | 2006-11-15 | F.Hoffmann-La Roche Ag | Devices and methods for diagnosing or predicting early stage cardiac dysfunctions |
| JP2009541287A (ja) * | 2006-06-20 | 2009-11-26 | リポペプチド・アクチエボラーグ | 抗癌剤としてのカテリシジン抗菌タンパク質(hCAP18)の使用 |
| WO2013083781A2 (en) * | 2011-12-08 | 2013-06-13 | Pronota N.V. | Biomarkers and test panels useful in systemic inflammatory conditions |
| US20150072360A1 (en) * | 2011-12-14 | 2015-03-12 | The Johns Hopkins University | Biomarkers of pulmonary hypertension |
| WO2014028734A1 (en) * | 2012-08-15 | 2014-02-20 | The Procter & Gamble Company | Human ex vivo skin model and use in methods of identifying modulators of skin inflammation |
| CN104049082B (zh) * | 2014-05-30 | 2016-03-16 | 华中科技大学同济医学院附属同济医院 | 人组织激肽释放酶活性检测试剂盒及其应用 |
| CN105987998B (zh) * | 2015-01-30 | 2017-12-29 | 江苏众红生物工程创药研究院有限公司 | 人组织激肽释放酶1elisa定量检测试剂盒 |
-
2018
- 2018-08-08 JP JP2020507022A patent/JP7414281B2/ja active Active
- 2018-08-08 CN CN201880063136.3A patent/CN111465857A/zh active Pending
- 2018-08-08 AU AU2018315056A patent/AU2018315056B2/en active Active
- 2018-08-08 EP EP18844704.9A patent/EP3665483A4/en not_active Withdrawn
- 2018-08-08 WO PCT/AU2018/050827 patent/WO2019028507A1/en not_active Ceased
- 2018-08-08 US US16/636,403 patent/US20200174021A1/en not_active Abandoned
-
2021
- 2021-09-13 AU AU2021232662A patent/AU2021232662B2/en active Active
Patent Citations (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002094870A2 (en) * | 2000-11-02 | 2002-11-28 | Curagen Corporation | Proteins and nucleic acids encoding same |
| WO2002061131A2 (en) * | 2000-12-04 | 2002-08-08 | Bristol-Myers Squibb Company | Human single nucleotide polymorphisms |
| US20040033582A1 (en) * | 2002-06-03 | 2004-02-19 | Manling-Ma Edmonds | Human single nucleotide polymorphisms |
| CN1703523A (zh) * | 2002-09-30 | 2005-11-30 | 肿瘤疗法科学股份有限公司 | 诊断前列腺癌的方法 |
| WO2006008002A2 (en) * | 2004-07-23 | 2006-01-26 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with kallikrein 1 (klk1) |
| CN101031640A (zh) * | 2004-07-29 | 2007-09-05 | 干细胞创新有限公司 | 干细胞的分化 |
| CN101340928A (zh) * | 2005-10-21 | 2009-01-07 | 催化剂生物科学公司 | 抑制补体激活的修饰的蛋白酶 |
| US20080057590A1 (en) * | 2006-06-07 | 2008-03-06 | Mickey Urdea | Markers associated with arteriovascular events and methods of use thereof |
| WO2008000067A1 (en) * | 2006-06-26 | 2008-01-03 | Vasogen Ireland Limited | Treatment of mild chronic heart failure in human patients |
| CN101517074A (zh) * | 2006-07-05 | 2009-08-26 | 催化剂生物科学公司 | 蛋白酶筛选方法及由此鉴别的蛋白酶 |
| CN103289980A (zh) * | 2006-07-05 | 2013-09-11 | 催化剂生物科学公司 | 蛋白酶筛选方法及由此鉴别的蛋白酶 |
| US20100267052A1 (en) * | 2006-09-01 | 2010-10-21 | American Type Culture Collection | Compositions and methods for diagnosis and treatment of type 2 diabetes |
| US20080300170A1 (en) * | 2006-09-01 | 2008-12-04 | Cohava Gelber | Compositions and methods for diagnosis and treatment for type 2 diabetes |
| CN103642902A (zh) * | 2006-11-30 | 2014-03-19 | 纳维哲尼克斯公司 | 遗传分析系统和方法 |
| CN101617227A (zh) * | 2006-11-30 | 2009-12-30 | 纳维哲尼克斯公司 | 遗传分析系统和方法 |
| CN102858985A (zh) * | 2009-07-24 | 2013-01-02 | 西格马-奥尔德里奇有限责任公司 | 基因组编辑方法 |
| US20130116343A1 (en) * | 2010-04-21 | 2013-05-09 | Board Of Regents Of The University Of Texas System | Salivary Protein Markers for Detection of Breast Cancer |
| US20120219943A1 (en) * | 2011-02-03 | 2012-08-30 | Abbott Laboratories | Methods of prognosis and diagnosis in chronic heart failure |
| CN103403554A (zh) * | 2011-02-03 | 2013-11-20 | 雅培制药有限公司 | 慢性心力衰竭的预后和诊断方法 |
| US20170051053A1 (en) * | 2011-12-28 | 2017-02-23 | Immunoqure Ag | Method of providing monoclonal auto-antibodies with desired specificity |
| US20150291966A1 (en) * | 2012-07-25 | 2015-10-15 | The Broad Institute, Inc. | Inducible dna binding proteins and genome perturbation tools and applications thereof |
| WO2014193999A2 (en) * | 2013-05-28 | 2014-12-04 | Caris Science, Inc. | Biomarker methods and compositions |
| WO2016134365A1 (en) * | 2015-02-20 | 2016-08-25 | The Johns Hopkins University | Biomarkers of myocardial injury |
Non-Patent Citations (13)
| Title |
|---|
| ANNE, PIZARD;CHRISTINE, RICHER;NADINE, BOUBY;NICOLAS, PICARD;PIERRE, MENETON;MICHEL, AZIZI;FRAN?OIS, ALHENC-GELAS: "Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney.", BIOLOGICAL CHEMISTRY, vol. 389, 31 December 2008 (2008-12-31) * |
| CHING-YUN, CHANG;PAOLA, PICOTTI;RUTH, HÜTTENHAIN;VIOLA, HEINZELMANN-SCHWARZ;MARKO, JOVANOVIC;RUEDI, AEBERSOLD;OLGA, VITEK: "Protein significance analysis in selected reaction monitoring (SRM) measurements.", MOLECULAR & CELLULAR PROTEOMICS, vol. 11, 31 December 2012 (2012-12-31) * |
| TIMOTHY CLOUGH, ET AL.: "Statistical protein quantification and significance analysis in label-free LC-MS experiments with complex designs.", BMC BIOINFORMATICS, vol. 13, 31 December 2012 (2012-12-31) * |
| XI, ZHANG;TERRY, WALSH;JOHN J, ATHERTON;KARAM, KOSTNER;BENJAMIN, SCHULZ;CHAMINDIE, PUNYADEERA: "Identification and Validation of a Salivary Protein Panel to Detect Heart Failure Early.", THERANOSTICS, vol. 7, no. 18, 26 September 2017 (2017-09-26), XP055794321, DOI: 10.7150/thno.21727 * |
| 余惠珍;谢良地;朱鹏立;许昌声;王华军;李体远;: "人KLK1和EGFP双顺反子重组腺病毒构建及其在血管平滑肌细胞中的表达", 中国病理生理杂志, no. 02, 15 February 2008 (2008-02-15) * |
| 庄伟;谢良地;许昌声;王华军;沈逸华;陈明;: "脂肪组织基质血管组分移植抑制阿霉素诱导的心力衰竭大鼠心肌重构", 福建医科大学学报, no. 05, 28 October 2013 (2013-10-28) * |
| 张乐;胡中扬;杨杰;李蜀渝;曾艺;刘宝琼;杜小平;夏健;刘运海;许宏伟;杨期东;: "KLK1基因rs3212855和rs5515多态性与长沙地区汉族人群脑出血的关联研究", 中南大学学报(医学版), no. 12, 15 December 2010 (2010-12-15) * |
| 张淑群, 强水云, 王西京, 纪宗正, 李妙羡: "血清T-PSA和F-PSA检测在乳腺癌诊断中的意义", 中国肿瘤临床, no. 17, 25 May 2005 (2005-05-25) * |
| 王燕;高友鹤;: "微小病变性肾病早期差异尿蛋白质组分析", 基础医学与临床, no. 03, 5 March 2010 (2010-03-05) * |
| 王锦霞;常乘;马洁;吴松锋;庄举娟;朱云平;: "基于质谱技术筛选差异表达蛋白的统计学策略研究进展", 中国科学:生命科学, no. 04, 20 April 2015 (2015-04-20) * |
| 章文莉;苏津自;: "激肽释放酶-激肽系统对心血管系统的保护作用", 实用老年医学, no. 04, 20 August 2007 (2007-08-20) * |
| 陈清标;蔡超;陈佳鸿;秦国强;陈锡彬;王月生;梁宇翔;韩兆冬;毕学成;钟惟德;: "纳米金标芯片检测用于前列腺癌多基因诊断的实验研究", 现代泌尿生殖肿瘤杂志, no. 01, 22 February 2011 (2011-02-22) * |
| 鲍丹;吕丹;董伟;陈炜;路迎冬;张连峰;: "转基因表达KLK1抵抗压力负荷引起的心室重构", 中国分子心脏病学杂志, no. 03, 25 June 2013 (2013-06-25) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024007778A1 (zh) * | 2022-07-05 | 2024-01-11 | 上海交通大学医学院附属上海儿童医学中心 | 一种血浆分子标志物犬尿氨酸在早期心力衰竭检测中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3665483A1 (en) | 2020-06-17 |
| US20200174021A1 (en) | 2020-06-04 |
| AU2021232662A1 (en) | 2021-10-07 |
| EP3665483A4 (en) | 2021-07-14 |
| AU2021232662B2 (en) | 2023-06-01 |
| AU2018315056A1 (en) | 2020-03-26 |
| AU2018315056B2 (en) | 2021-06-17 |
| JP7414281B2 (ja) | 2024-01-16 |
| JP2020530120A (ja) | 2020-10-15 |
| WO2019028507A1 (en) | 2019-02-14 |
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Effective date of abandoning: 20250221 |