CN1114613C - 蛋白质溶液的铝/铁处理和膜浓缩方法 - Google Patents

蛋白质溶液的铝/铁处理和膜浓缩方法 Download PDF

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Publication number
CN1114613C
CN1114613C CN96194380.7A CN96194380A CN1114613C CN 1114613 C CN1114613 C CN 1114613C CN 96194380 A CN96194380 A CN 96194380A CN 1114613 C CN1114613 C CN 1114613C
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China
Prior art keywords
protein solution
test
aluminum
concentration
protein
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Expired - Fee Related
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CN96194380.7A
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English (en)
Chinese (zh)
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CN1186498A (zh
Inventor
T·K·尼尔森
M·A·拉斯特森
N－V·尼尔森
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Novozymes AS
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Novozymes AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN96194380.7A 1995-06-02 1996-05-31 蛋白质溶液的铝/铁处理和膜浓缩方法 Expired - Fee Related CN1114613C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK62695 1995-06-02
DK0626/1995 1995-06-02
DK0626/95 1995-06-02

Publications (2)

Publication Number Publication Date
CN1186498A CN1186498A (zh) 1998-07-01
CN1114613C true CN1114613C (zh) 2003-07-16

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ID=8095720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96194380.7A Expired - Fee Related CN1114613C (zh) 1995-06-02 1996-05-31 蛋白质溶液的铝/铁处理和膜浓缩方法

Country Status (9)

Country Link
EP (1) EP0828753B1 (https=)
JP (1) JPH11511118A (https=)
CN (1) CN1114613C (https=)
AT (1) ATE235506T1 (https=)
AU (1) AU5996996A (https=)
DE (1) DE69626976T2 (https=)
DK (1) DK0828753T3 (https=)
IN (1) IN181859B (https=)
WO (1) WO1996038469A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2810667B1 (fr) * 2000-06-23 2004-09-03 Warner Lambert Co Procede d'isolement et de purification d'une proteine, et proteine obtenue
US7659102B2 (en) 2001-02-21 2010-02-09 Verenium Corporation Amylases, nucleic acids encoding them and methods for making and using them
EP2292784A3 (en) 2001-02-21 2011-06-22 Verenium Corporation Enzymes having alpha amylase activity and methods of use thereof
WO2002092802A1 (en) * 2001-05-14 2002-11-21 Diversa Corporation Novel methods of enzyme purification
WO2003002136A2 (en) 2001-06-28 2003-01-09 Novo Nordisk A/S Stable formulation of modified glp-1
US7118891B2 (en) 2001-12-11 2006-10-10 Novozymes A/S Crystal harvest from fermentation broth
EP1456361B1 (en) * 2001-12-11 2012-02-29 Novozymes A/S Process for harvesting crystalline particles from fermentation broth
CN111484996A (zh) 2003-03-06 2020-08-04 巴斯夫酶有限责任公司 淀粉酶、编码它们的核酸及其制备和应用方法
PL1633391T3 (pl) 2003-06-03 2012-03-30 Novo Nordisk As Stabilizowane farmaceutycznie kompozycje peptydowe
KR101308912B1 (ko) 2003-06-03 2013-09-23 노보 노르디스크 에이/에스 안정화된 약학적 펩티드 조성물
DK3300721T4 (da) 2003-11-20 2025-03-03 Novo Nordisk As Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
PL1789434T3 (pl) 2004-08-31 2014-07-31 Novo Nordisk As Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek
MX2007005521A (es) 2004-11-12 2007-05-18 Novo Nordisk As Formulaciones estables de peptidos insulinotropicos.
US7855280B2 (en) 2005-09-15 2010-12-21 Wyeth Llc Separation methods
PL2479267T3 (pl) 2006-12-21 2017-06-30 Basf Enzymes Llc Amylazy i glukoamylazy, kwasy nukleinowe kodujące te związki oraz sposoby wytwarzania tych związków oraz stosowania ich
US20120252066A1 (en) * 2011-03-29 2012-10-04 Heng Meng H Methods of foam control
EP2914611B1 (en) 2012-11-01 2018-08-29 Novozymes A/S Method for removal of dna
WO2015075302A1 (en) 2013-11-19 2015-05-28 Kemira Oyj Method for reducing colour of a biotechnological liquid
KR102665710B1 (ko) 2017-08-24 2024-05-14 노보 노르디스크 에이/에스 Glp-1 조성물 및 그 용도
CN108949703A (zh) * 2018-06-28 2018-12-07 大连理工大学 一种半纤维小体类似物粗提纯方法
US12146171B2 (en) 2019-06-13 2024-11-19 Basf Se Method of recovering a protein from fermentation broth using a divalent cation
JP7761567B2 (ja) 2020-02-18 2025-10-28 ノヴォ ノルディスク アー／エス 医薬製剤
MX2023003276A (es) 2020-09-22 2023-05-03 Basf Se Método para recuperar una proteína de un caldo de fermentación que comprende un alto grado de células lisadas.
CN112500471B (zh) * 2020-12-22 2022-09-27 中美华世通生物医药科技(武汉)股份有限公司 一种制备高澄清度蛋白琥珀酸铁的方法
US20260062690A1 (en) 2022-08-02 2026-03-05 Basf Se Stabilized protein production process using bacillus host cells

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795586A (en) * 1969-08-11 1974-03-05 Pabst Brewing Co Recovery of enzymes
PL270368A1 (en) * 1987-01-30 1988-10-13 Int Minerals & Chem Corp Method for recovery of somatotropins from diluted water solutions
US4894444A (en) * 1987-07-16 1990-01-16 Merck & Co., Inc. Recovery and purification of immunogens from immunogen-alum complexes
DE3915277A1 (de) * 1989-05-10 1990-11-15 Henkel Kgaa Verfahren zur reinigung von enzymfluessigkonzentraten
DE4037530A1 (de) * 1990-11-26 1992-05-27 Henkel Kgaa Faellungsverfahren fuer exocellulaere proteine
DK91092D0 (https=) * 1992-07-10 1992-07-10 Novo Nordisk As

Also Published As

Publication number Publication date
WO1996038469A1 (en) 1996-12-05
DK0828753T3 (da) 2003-06-30
EP0828753A1 (en) 1998-03-18
AU5996996A (en) 1996-12-18
JPH11511118A (ja) 1999-09-28
DE69626976D1 (de) 2003-04-30
DE69626976T2 (de) 2004-03-04
CN1186498A (zh) 1998-07-01
ATE235506T1 (de) 2003-04-15
IN181859B (https=) 1998-10-03
EP0828753B1 (en) 2003-03-26

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Applicant before: Novo Nordisk A/S

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Termination date: 20120531