CN111450297A

CN111450297A - Marine fucoidin herbal atomizing agent and preparation method thereof

Info

Publication number: CN111450297A
Application number: CN202010336395.8A
Authority: CN
Inventors: 姜进举; 王璐璐; 张健; 李可昌; 王发合; 张国防
Original assignee: Qingdao Mingyue Algae Bio Health Technology Co ltd
Current assignee: Qingdao Mingyue Algae Bio Health Technology Co ltd
Priority date: 2020-04-26
Filing date: 2020-04-26
Publication date: 2020-07-28

Abstract

The invention relates to the technical field of health and sanitation protection, and provides a marine fucoidin herbal atomizing agent and a preparation method thereof. The main functional raw material used is fucoidin, the source of the fucoidin is seaweed such as kelp, undaria pinnatifida and the like which are homologous in medicine and food, researches show that the fucoidin has wide antiviral effect, can enhance and protect the immune system and reduce inflammation, and is usually made into an oral food or medicine form; the preparation process adopts a high-pressure homogenization process, so that the components of the herbal raw materials are fully uniform, the particle size of material particles reaches the micron level or below the nanometer level, the dispersion of effective substances during atomization is facilitated, the external contact area is increased, the antibacterial and antiviral efficiency is improved, the settling speed of the particles in the air is reduced during external application due to the reduction of the particle size, and the particles can suspend in the air for a long time when the particle size is less than 10 mu m, so that the effective time of the atomizing agent is prolonged.

Description

Marine fucoidin herbal atomizing agent and preparation method thereof

Technical Field

The invention relates to the technical field of health and sanitation protection, and particularly relates to a marine fucoidin herbal atomizing agent and a preparation method thereof.

Background

The immune system has the functions of immune monitoring, defense and regulation, the human body has three immune defense lines, the first defense line is skin and mucous membrane, and the skin and the mucous membrane are the first barrier for preventing infection, so that the protection of the integrity and the health of the mucous membrane has important significance for maintaining the health of the body. The second line of defense is the bactericidal substances and phagocytic cells in the body fluid, which to some extent can kill foreign "invaders" that invade the body. The first and second lines of defense are established and have a defense against all pathogens, and are therefore called non-specific immunity. The third line of defense of the human body mainly consists of immune organs and immune cells, is a defense function which is gradually established after birth, only acts on a specific pathogen, and belongs to specific immunity. The living environment of people is full of viruses, germs and other pathogens, people with low immunity cannot resist the invasion of the pathogens, are very easy to infect and get ill, and have longer course and more serious illness compared with people with high immunity. In the new coronavirus pneumonia outbreaks in autumn and winter in 2019, some people have lighter symptoms, while some people are seriously ill or even lose lives, while some people are not infected even if the people are contacted with the disease, which depends on the pathogenicity and the dosage of the contacted virus on one hand, and on the other hand, the new coronavirus pneumonia is also influenced by the difference of individual immunity, so that the contact of the new coronavirus pneumonia with pathogenic bacteria and viruses is reduced, the capability of resisting pathogenic bacteria and viruses of an immune system is improved, and the new coronavirus pneumonia is vital to keeping health in the period of high incidence of infectious diseases such as influenza and the like and even in the case of emergent epidemic diseases.

Fucoidin, also known as fucoidan and fucoidan sulfate, is extracted from the surface mucus of marine brown algae such as kelp, Undaria pinnatifida, etc., which are homologous in medicine and food, and is unique functional sulfated polysaccharide in the sea. A large number of scientific researches find that the fucoidin not only can activate and protect the human immune system, increase the lethality of T cells, NK cells and the like, reduce inflammation and protect and strengthen the immune defense line of a human body, but also has wide antiviral activity (such as RNA virus, HIV virus, human papilloma virus, influenza virus, human cytomegalovirus and the like), can directly compete with the virus for the binding site of host cell surface protein to inhibit virus adsorption, or inhibit the virus replication by inhibiting the activity of reverse transcriptase to realize the antiviral effect. Because the virus is a strict cell parasite and all life cycles involve the utilization of host cell components, the traditional antiviral drugs are difficult to act only on the virus without influencing the normal functions of the host cells, so the antiviral drugs usually have larger toxic and side effects on organisms and need to be used carefully; compared with the prior art, the research finds that the marine fucoidin has the advantages of low toxicity, high efficiency and the like in the aspect of antivirus.

After the outbreak of the new coronavirus epidemic situation, experts and scholars recommend to supplement vitamin C to improve the autoimmunity and prevent virus infection, and even a team has developed the clinical research of treating the new coronavirus by the vitamin C. Scientific research shows that the fucoidin has an antioxidant function and can increase the stability of vitamin C, and the fucoidin and the vitamin C have a synergistic effect.

Since ancient times, Chinese has been known that Chinese herbal medicines can eliminate pestilence, and the pestilence refers to antigenic substances such as viruses and germs which can cause human diseases by combining modern scientific research.

Mugwort generally refers to mugwort, which is one of the earliest medicinal plants, has many effects, such as antibacterial and antiviral effects, antiasthmatic, antitussive, expectorant, and resistance improvement, and mugwort is warm in nature and non-toxic, and is also called as "medical herb" in "compendium of materia Medica", not only that, spraying mugwort water or igniting dry mugwort has been used for daily disinfection.

Rhizoma atractylodis is recorded in Chinese pharmacopoeia (2015 edition) and approved by health department to be used in health food, when SARS epidemic outbreak occurs in 2003, Shenzhen hospital adopts rhizoma atractylodis smoke air disinfection method for disinfection, which has good inhibition effect on SARS virus propagation, and rhizoma atractylodis is non-toxic, harmless, non-irritant and fragrant in smell, so that the rhizoma atractylodis not only can be disinfected in the presence of people, but also sensitive people such as mothers and babies can be used with confidence.

The dandelion is also named as the famous woman, is recorded in the compendium of materia medica, can clear away heat and toxic materials, digest and eliminate indigestion, is highly evaluated and confirmed in medical monographs such as Chinese medicine dictionary, Tang Ben Cao and Shen nong Ben Cao Jing, has certain antibacterial and antiviral effects, and has obvious effect of resisting H1N1 influenza virus in vitro.

In addition, honeysuckle, liquorice, astragalus, ginger, onion, mint, β -glucan, garlic and plant polyphenol are all traditional edible raw materials, health-care raw materials or medicinal and edible raw materials, and the effects of the honeysuckle, the liquorice, the astragalus, the ginger, the onion, the mint, the β -glucan and the garlic on immunity enhancement, antibiosis and antivirus are generally accepted by the public.

One of the fundamental links in which infectious diseases can become prevalent among people is the "transmission pathway", i.e., the path through which pathogens leave the source of infection to reach healthy humans, commonly known as droplet transmission, aerosol transmission, dietary transmission, body fluid transmission, contact transmission, and the like. Therefore, cutting off the transmission pathway is of great significance for the prevention of infectious diseases. Compared with other transmission ways, the transmission of droplets and aerosol is difficult to block, and the effective antibacterial disinfection of air can greatly reduce the concentration of pathogens, thereby reducing the probability of infection of human bodies.

Health protection products such as 75% alcohol, 84 disinfectant and the like have pungent taste, are usually used for inhibiting and killing pathogens in an in-vitro space and blocking a transmission path, and traditional functional foods or medicines are digested and absorbed by a human digestive tract to improve immunity or inhibit and kill the pathogens. The health protection product of the herbal raw materials is made into the form of the atomizing agent which is convenient to use, so that the air can be directly cleaned, pathogens can be inhibited and killed, the functional components can directly reach respiratory tract mucous membranes through breathing, and the first immune defense line of a human body is protected and strengthened. Therefore, the herbal atomizing agent which contains the components with the effects of resisting bacteria and viruses and improving the immunity, is friendly in taste and small in irritation is developed to be used as a daily health protection product, and has wide market prospect.

Disclosure of Invention

Based on the background, the invention aims to provide a marine fucoidan herbal atomizing agent for health protection; the invention also aims to provide a preparation method of the marine fucoidan herbal atomizing agent. The health-care product is added with fucoidin, vitamin C, mugwort, rhizoma atractylodis, dandelion, honeysuckle, liquorice and other health raw materials with the effects of resisting bacteria and viruses and enhancing immunity, and can be used for cleaning air or enabling the functional substances to directly reach respiratory tracts through breathing, thereby achieving the purposes of daily health protection and body resistance improvement.

The invention adopts the following technical scheme:

a marine fucoidin herbal atomizing agent comprises an effective component, an auxiliary effective component and auxiliary materials used for a spraying agent or a propellant and an additive used for an aerosol, wherein the effective component is fucoidin, and the auxiliary effective component is vitamin C, mugwort, rhizoma atractylodis, dandelion, honeysuckle and liquorice.

Furthermore, according to the mass percentage, the fucoidin is 0.5 to 70 percent, the vitamin C is 0.005 to 2 percent, the mugwort is 0.1 to 25 percent, the atractylodes rhizome is 0.1 to 25 percent, the dandelion is 0.1 to 25 percent, the honeysuckle is 0.1 to 15 percent, and the liquorice is 0.1 to 15 percent.

Furthermore, the mugwort, the rhizoma atractylodis, the dandelion, the honeysuckle and the liquorice are all raw material extracts or raw material leaching liquor.

In the technical scheme, all the raw materials are soluble extracts.

Further, the effective components also comprise radix astragali, rhizoma Zingiberis recens, Bulbus Allii Cepae, herba Menthae, β -dextran, Bulbus Allii and/or plant polyphenol.

Furthermore, according to the mass percentage, the astragalus membranaceus is 0.1-10%, the ginger is 0.1-10%, the onion is 0.1-5%, the mint is 0.05-5%, the β -glucan is 0.01-1%, the garlic is 0.05-3%, and the plant polyphenol is 0.01-5%.

Furthermore, the astragalus, the ginger, the onion, the mint and the garlic are all raw material extracts or raw material leaching liquor.

In the technical scheme, all the raw materials are soluble extracts.

Further comprises sweetener, essence or plant essential oil and deionized water.

Furthermore, according to the mass percentage, 0.001 to 10 percent of sweetening agent, 0.01 to 3 percent of essence or plant essential oil, 1 to 85 percent of auxiliary material used by the spraying agent or propellant and additive used by the aerosol, and the balance of deionized water.

A preparation method of a marine fucoidin herbal atomizing agent comprises the following steps:

s1: adding deionized water with a formula amount into a mixing tank, starting stirring and circulating, adding the raw materials into the mixing tank according to the mixture ratio, and performing high-speed circulating stirring for 10-20 min to obtain mixed feed liquid;

s2: preheating the uniformly mixed feed liquid to 70-80 ℃, filtering the feed liquid by an online filter, and then feeding the feed liquid into a deaerator, wherein the vacuum degree control range of the deaerator is 0.50-0.75Bar, degassing the material by the deaerator, and then feeding the material into a high-pressure homogenizer for homogenization to obtain micron-sized or below-nanometer uniform particles, wherein the homogenization pressure range is 200-2000Bar, obtaining a uniform solution after homogenization, and feeding the uniform solution into a buffer tank for later use;

s3: and (3) filling the prepared homogeneous solution into a corresponding spray bottle, or filling the homogeneous solution and a propellant and an additive for aerosol into the corresponding aerosol bottle together to obtain the marine fucoidin herbal atomizing agent.

Further, in step S3, the obtained homogeneous solution can be prepared into instant granules by fluidized bed granulation process, and the granules are re-dissolved with water before use, and then filled into corresponding aerosol bottles, or filled into corresponding aerosol bottles together with the propellant and the additive for the aerosol to obtain the marine fucoidan herbal atomizing agent.

In the technical scheme, the stock solution of the prepared atomizing agent can be prepared into instant granules by a fluidized bed granulation process, and the granules are re-dissolved with water before use.

Further, the nebulant is an aerosol or a spray.

Furthermore, the auxiliary materials used by the spray or the propellant and additive used by the aerosol are food, cosmetic or pharmaceutical preparations.

The invention has the beneficial effects that:

(1) the main functional raw material used by the invention is fucoidin which is derived from seaweed such as kelp, undaria pinnatifida and the like which are homologous in medicine and food, and researches show that the fucoidin has wide antiviral effect, can enhance and protect the immune system and reduce inflammation. The fucoidin is usually made into an oral food or medicine form, and the fucoidin is innovatively made into a health protection product of the atomizing agent, so that the application of the product is expanded;

(2) the invention adopts healthy raw materials with antibacterial and antiviral effects which can be used in foods, cosmetics or medicines, can be used as daily health protection, and has high safety;

(3) compared with the traditional chemical disinfection preparations such as 75% alcohol, chlorine-containing disinfectants and the like, the novel health protection product is convenient to transport and store, is friendly in taste, has small irritation and small harm to human skin and mucous membrane;

(4) the preparation process adopts a high-pressure homogenization process, so that the components of the herbal raw materials are fully uniform, the precipitation is reduced, the particle size of material particles reaches the micron level or below the nanometer level, the dispersion of effective substances during atomization is facilitated, the external contact area is increased, the antibacterial and antiviral efficiency is improved, meanwhile, due to the reduction of the particle size, the settling speed of the particles in the air is reduced when the particles are used externally, and when the particle size is less than 10 micrometers, the particles can be suspended in the air for a long time, so that the effective time of the atomizing agent is prolonged;

(5) the atomizing agent can be prepared into loose and porous solid particles through a granulation process, is easy to disperse and dissolve, is more favorable for storage and transportation in a solid form, and is more convenient to use in the existing preparation.

Detailed Description

The invention is described in detail below with reference to specific embodiments:

example 1:

a marine fucoidin herbal atomizing agent is prepared from the following raw materials in parts by weight:

1% of fucoidin, 0.7% of vitamin C, 1% of Artemisia argyi leaching liquor, 15% of rhizoma atractylodis leaching liquor, 15% of dandelion leaching liquor, 12% of honeysuckle leaching liquor, 3% of liquorice leaching liquor, 1% of radix astragali leaching liquor, 2% of ginger leaching liquor, 1.5% of mint extract, 2% of plant polyphenol, 0.3% of essence, 0.5% of PEG 40-hydrogenated castor oil and the balance of deionized water.

S1: adding water with the formula amount into a mixing tank, starting stirring and circulating, adding the raw materials into the mixing tank according to the ratio, and performing high-speed circulating stirring for 15 min.

S2: preheating the uniformly mixed feed liquid to 72.5 ℃, filtering the feed liquid by an online filter, then feeding the feed liquid into a deaerator, controlling the vacuum degree of the deaerator within 0.6Bar, deaerating the feed liquid by the deaerator, feeding the feed liquid into a high-pressure homogenizer for homogenizing to obtain uniform particles below micron level, controlling the homogenizing pressure within 240Bar, and feeding the homogenized feed liquid into a buffer tank for cooling to room temperature.

S3: packaging the obtained homogeneous solution into spray bottle.

Example 2:

50% of fucoidin, 0.5% of vitamin C, 0.5% of artemisia argyi leaching liquor, 3% of rhizoma atractylodis leaching liquor, 2.5% of dandelion leaching liquor, 2.5% of honeysuckle leaching liquor, 1% of liquorice leaching liquor, 0.8% of astragalus mongholicus leaching liquor, 0.5% of ginger leaching liquor, 0.3% of onion leaching liquor, 0.3% of mint leaching liquor, 0.06% of β -glucan, 0.09% of garlic extract, 0.05% of plant polyphenol, 0.08% of sweetener, 0.05% of plant essential oil, 1% of PEG 40-hydrogenated castor oil and the balance of deionized water.

S1: adding water with the formula amount into a mixing tank, starting stirring and circulating, adding the raw materials into the mixing tank according to the ratio, and performing high-speed circulating stirring for 10 min.

S2: preheating the uniformly mixed feed liquid to 72.5 ℃, filtering the feed liquid by an online filter, then feeding the feed liquid into a deaerator, controlling the vacuum degree of the deaerator within 0.65Bar, deaerating the feed liquid by the deaerator, feeding the feed liquid into a high-pressure homogenizer for homogenizing to obtain uniform particles below nano level, controlling the homogenizing pressure within 1100Bar, and feeding the feed liquid into a buffer tank for cooling to room temperature after the homogenization is completed.

S3: drying the obtained homogeneous solution by a fluidized bed and granulating.

S4: when in use, the medicine is prepared according to the following steps of 1: the atomized liquid can be obtained by mixing with cold water with the proportion of 10.

A comparison of the marine fucoidan herbal nebulizer prepared as in example 2 with other disinfectant formulations is shown in table 1.

TABLE 1 comparison of marine fucoidan herbal nebulizer with other disinfectant formulations

Example 3:

12% of fucoidin, 0.01% of vitamin C, 0.8% of Artemisia argyi extract, 0.8% of rhizoma atractylodis extract, 2% of dandelion extract, 1.3% of honeysuckle extract, 0.9% of licorice extract, 0.4% of radix astragali extract, 0.2% of ginger extract, 0.1% of onion extract, β -glucan 0.01%, 0.05% of garlic extract and 21.43% of deionized water.

S1: adding water with the formula amount into a mixing tank, starting stirring and circulating, adding the raw materials into the mixing tank according to the ratio, and performing high-speed circulating stirring for 20 min.

S2: preheating the uniformly mixed feed liquid to 78 ℃, filtering the feed liquid by an online filter, then feeding the feed liquid into a deaerator, controlling the vacuum degree of the deaerator within 0.70Bar, deaerating the feed liquid by the deaerator, feeding the feed liquid into a high-pressure homogenizer for homogenizing to obtain uniform particles below nano level, controlling the homogenizing pressure within 1500Bar, and feeding the homogenized feed liquid into a buffer tank for cooling to room temperature after the homogenization is completed.

S3: adding the prepared uniform solution into an aerosol sealed container, and then pressing 60% of propellant to obtain the herbal aerosol.

Other combinations not exemplified are obvious implementations under the guidance of the above examples 1-3.

The parts which are not described in the invention can be realized by taking the prior art as reference.

It is to be understood that the above description is not intended to limit the present invention, and the present invention is not limited to the above examples, and those skilled in the art may make modifications, alterations, additions or substitutions within the spirit and scope of the present invention.

Claims

1. A marine fucoidin herbal atomizing agent is characterized by comprising an effective component, an auxiliary effective component and auxiliary materials used for a spraying agent or a propellant and an additive used for an aerosol, wherein the effective component is fucoidin, and the auxiliary effective component is vitamin C, mugwort, rhizoma atractylodis, dandelion, honeysuckle and liquorice.

2. The marine fucoidin herbal atomizing agent as claimed in claim 1, wherein the marine fucoidin herbal atomizing agent is characterized by comprising, by mass, 0.5-70% of fucoidin, 0.005-2% of vitamin C, 0.1-25% of mugwort, 0.1-25% of rhizoma atractylodis, 0.1-25% of dandelion, 0.1-15% of honeysuckle and 0.1-15% of liquorice.

3. The marine fucoidan herbal nebulizer of claim 1, wherein the mugwort, the rhizoma atractylodis, the dandelion, the honeysuckle and the liquorice are raw material extracts or raw material leaching solutions.

4. The marine fucoidan herbal nebulizer of claim 1 or 2, wherein the active ingredients further comprise astragalus, ginger, onion, mint, β -glucan, garlic and/or plant polyphenols.

5. The marine fucoidan herbal nebulizer of claim 4, wherein the marine fucoidan herbal nebulizer comprises, by mass, 0.1-10% of radix astragali, 0.1-10% of ginger, 0.1-5% of onion, 0.05-5% of mint, 0.01-1% of β -glucan, 0.05-3% of garlic, and 0.01-5% of plant polyphenol.

6. The marine fucoidan herbal nebulizer of claim 4, wherein the radix astragali, the ginger, the onion, the mint and the garlic are raw material extracts or raw material leaching solutions.

7. The marine fucoidan herbal nebulizer of claim 1 or 2, further comprising sweetener, essence or plant essential oil and deionized water.

8. The marine fucoidin herbal atomizing agent as claimed in claim 7, wherein the atomizing agent comprises, by mass, 0.001-10% of a sweetener, 0.01-3% of an essence or a plant essential oil, 1-85% of an adjuvant or a propellant and an additive for an aerosol used by a spray, and the balance deionized water.

9. A preparation method of a marine fucoidin herbal atomizing agent is characterized by comprising the following steps:

10. The method for preparing a marine fucoidan herbal nebulizer of claim 9, wherein in step S3, the obtained homogeneous solution can be prepared into instant granules by a fluidized bed granulation process, and the instant granules are reconstituted with water before use and then filled into a corresponding aerosol bottle, or filled into a corresponding aerosol bottle together with a propellant and an additive for an aerosol to obtain the marine fucoidan herbal nebulizer.