CN1475204A - Medicinal Composition, dry powder vapor, nebula, nebula auxiliary preparation for use through mouth and nose and its preparation method - Google Patents

Abstract

A composition, dry-powder inhalant, spray, or spray aided medicine for treating cold, cough, angina pectoris, etc by applying it via mouth or nose is mainly prepared from natural milk and plant extract oil with fragrant therapy function. Its preparing process is also disclosed. Its advantages are less irritation to nasal mucose, long stay time in nasal cavity, high enzyme suppressing action, and high biological utilization rate.

Description

The compositions of per os, nasal administration, Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent and preparation method thereof

The invention belongs to compositions, the preparation of per os, nasal administration, and preparation method thereof.

Numerous disease need change traditional medicine-feeding way in the treatment of diseases process, in the hope of obtaining better therapeutic:

Topical, for example: flu is the local infection of nasal mucosa, virus does not enter blood with antibacterial under normal situation, needs topical; Rhinitis, allergic rhinitis mainly show as local symptom, need topical; Aphtha, mouthful tinea, toothache, gingival swelling and pain need topical; Laryngopharynx swelling and pain, tonsillitis often give Herba Pileae Scriptae Tabellae and larynx clinically and protect (sucking sugar), this is not the basic way of dealing with problems, touch less than throat because the effective ingredient of these two kinds of dosage forms only passes through pharyngeal when swallowing along with saliva, do not control the disease of larynx, need local spray delivery; Dry cough is that partial inflammation of larynx or ulcer belong to local excitation and causes, needs local spray delivery ...

Inferior topical, as respiratory system, blood circulation, nasal cavity, oral cavity and pulmonary's inhalation are faster than the oral administration speed that takes effect, and long action time.

To the brain administration, anatomy shows that nasal cavity is a part of skull, on many apertures are arranged, the endothelium of nasal cavity is just as a cribriform plate, nerve tract is by this aperture, cerebrospinal fluid abrim on every side, the part medicine can enter cerebrospinal fluid thus.Because this route of administration is more convenient than end vertebra drug administration by injection, and no pain.Therefore, when needs when brain is carried medicine, should first-selected nasal spray administration.As: treatment epilepsy, headache, convulsions, Parkinsonism, Mental Subnormality, excited, insomnia, intracranial hypertension, the cerebral tumor, alzheimer disease etc.

The whole body administration, many medicines just were degraded before entering the body circulation, comprised gastrointestinal tract degraded and metabolism, liver first-pass effect etc.These factors cause bioavailability of medicament reduction, action time to be lacked.In recent years, the nasal-cavity administration bioavailability of discovering many medicines is higher than oral administration.Especially along with the progress of biotechnology, increasing biochemical drug (protein and polypeptide drug) is used to treat various diseases, and these medicines generally can not be taked oral administration, even has part should not adopt parenteral route to carry out long-term treatment.Therefore, increasing formulation specialist turns to nasal cavity, oral cavity and pulmonary administration system to attention.

The dosage form of drug nasal administration has nasal drop, spray, Foradil Aerolizer formoterol fumarate.From assimilation effect: nasal drop since its to be subjected to contacting na-sal cavity surfaces restriction the assimilation effect long-pending little and factor that is easy to trickle the poorest, spray, Foradil Aerolizer formoterol fumarate assimilation effect are comparatively approaching, the spray preparation method is simple, easy to use, the less patient of nasal mucosa zest is glad uses: the holdup time of Foradil Aerolizer formoterol fumarate is long, good absorbing, the medicament contg height, the administration volume is little, and it is stable to help medicine; The dosage form of oral administration dosage form and nasal-cavity administration is closely same, also first-selected spray, Foradil Aerolizer formoterol fumarate; The first-selected aerosol of pulmonary administration, Foradil Aerolizer formoterol fumarate, but since the restriction people in fluorine Lyons focus progressively to turn on Foradil Aerolizer formoterol fumarate.

The present problem that exists:

1, for fat-soluble medicine, insoluble drug, when making nasal cavity administrated preparation such as emulsion-type, mixed suspension form, lipid build, non-natural surfactant, the additive that must use toxicity how, how genotoxic potential is people has a lingering fear and problem that inconvenience is explained.

2, albumen and polypeptide drugs are not having under the situation of absorption enhancer, and nasal cavity, oral cavity and pulmonary's assimilation effect are bad.It mainly is because it is toxic to the nose cilium that absorption enhancer commonly used is restricted in the use, and the damage that causes thus is expendable often.The direction of many researchs is to seek absorption enhancer effective and that toxicity is low, but makes little progress.

3, because oral mucosa has with the same multilamellar epithelial cell (having defencive function) of skin, and reaching the human oral mucosa does not have horny layer and keep moistening, therefore, oral mucosa is easier to infiltration than skin.But compared with the gastrointestinal tract mucous and nasal membrane of simple epithelium cell, the permeability of oral mucosa is less better, and the hypotonicity of oral mucosa also makes the absorption of medicine comparatively difficult.

4, the continuous secretion of saliva and swallowing in the oral cavity has been shortened the holdup time of medicine at oral mucosa, the factor that should consider when this point also is medication.

In addition, also have the problem that pharmaceutics still reckons without, promptly fragrant treatment is assisted a ruler in governing a country medicine and is totally treated problem:

In traditional, in the western proprietary preparation, have only a few liquid oral dosage form to use correctives always, rectify and smell agent, and its purpose is to hide the bad smell that medicine itself is had.Not seeing Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent is not the purpose of smelling in order to rectify, and initiatively utilizes the natural aromatic breath to stimulate olfactory receptor cell to reach to adjust mood (feel, psychology), balance immunity, assists a ruler in governing a country that medicine totally treats.

Aromatotherapy is derived by French Aroma (fragrance) and two nouns of Therapy (therapy).And carry out the main articles for use of champignon therapy, and be the essential oils (Essential Oil) that from plant, extract, also be champignon oil.The flower of some higher plant of nature, leaf, really, root, stem all have unique plant fragrance, it accepts the energy of the sun for plant, through photosynthesis, with the Conversion of energy of the sun, oozy essential oils.These essential oils are present in the intercellular substance of plant with the tiny droplets shape, are playing the part of the hormonal role of plant life, can help plant to adapt to surrounding, resist the disease and insect pest.Essential oils have contained the motive power of plant life, and many in fact elite oil properties also like the human hormone, have important function to human body, as have nervous system regulation, a hormonal system, digestion and Excretory system, and enhance immunity ability, the function of promotion cell regeneration.

It is indoor that Ancient Times in China well-known doctor Huatuo utilizes the flower sachet to be suspended from, to control diseases such as pulmonary tuberculosis, vomiting and diarrhoea.He also find out one the cover " with the flower cure the disease " method, for example the fragrance of Herba Menthae, Folium Perillae can effectively suppress duplicating of cold virus, alleviate patient have a headache the nasal obstruction watery nasal discharge hardship; Fragrance such as Lai Li, Flos Rosae Multiflorae, Flos Osmanthi Fragrantis, capable of purifying air, suppress the breeding of staphylococcus, tubercule bacillus etc.At the beginning of 1960's, French government finds that woman workers' neither one of the cool base of a fruit (Coty) perfume factory suffers from pneumonopathy when carrying out the pulmonary tuberculosis generaI investigation.This phenomenon is impelled people that the bactericidal effect of various spice, particularly natural essential oil is paid attention to and is deeply studied.Modern science men have found more than the 300 kind of fragrance of a flower to the human body beneficial, as can calm people's nerve of the fragrance of India flower; The fragrance of a flower of Hemerocallis citrina Baroni Cuculus polioephalus, Folium Rhododendri Daurici, Herba thymi vulgaris, Herba Rosmarini Officinalis and lavandula angustifolia can be treated asthma etc., the doctor of " convalescence area, fragrance of a flower park " of Baku, former Soviet Union Azerbaijan capital successfully treats diseases such as cardiovascular diseases, asthma, hypertension, liver cirrhosis, neurasthenia and insomnia with the fragrance of the doses of 15 kind of plant.According to Britain's one tame medical journal, there is human aromatic ammonia spirit (also being smelling salts) to rescue the patient of respiratory failure, be able to success.These illustrate that all the fragrance of a flower has the effect of curing the disease.According to experts' analysis, fragrance has the effect of regulative mechanism.After the people inhales the aroma, can promote immunoglobulin secretion, improve resistance, it has the stimulation olfactory receptor cell again simultaneously, and the whole body metabolism is regulated in excited and inhibition activity through the medium influence cerebral cortex, the balance vegetative nerve function makes physiology and restitution of psychological function normal.U.S.'s biologist was once foretold: 21 century is the spice epoch.Studies show that recently, fragrance not only can influence and regulate and control people's spirit and emotion, and control person's psychological behavior can also alleviate and alleviate people's slight illness.At present, the U.S., Britain, method state have " fragrant flower hospital ", cure the disease with the flower that the four seasons are open, allow patient suck the fragrance of a flower of doses, with this as a kind of medical procedure.Some bosses of factory of Japan then introduce the working space to specific aromatic odor, eliminate workman's fatigue and nervous with fragrance, reduce operate miss, increase work efficiency.

Now three of diabetes pathogenesis are example, can find out the fragrant application point for the treatment of in the disease treatment process:

Modern medicine study thinks that the mechanism that feelings will wound is brought out diabetes has three: the first, the variation of neuro-endocrinology hormone.Feelings will wound, promptly seven emotions too make body be in serious stress state.Body stimulates a large amount of secretion epinephrines, norepinephrine, adrenocortical hormone and glucagon by hypothalamo-pituitary-adrenal axis, these hormones all are the excretory hormones of Fructus Citri tangerinae glucagon, it hypoinsulinism occurs and causes blood sugar increasing to form diabetes for a long time.The second, neural direct effect.The so-called limbic system of modern medicine can be described as the emotion brain, and known emotional state and limbic system are in close relations.When emotion changes, activity that can be by each biorgan of nervous system and sympathetic nervous system function hyperfunction finally makes blood sugar increasing.The 3rd, changes in immune function mechanism.The immunologic function of human body is normal, is not subject to the pathogenic factor invasion and attack; And immunologic hypofunction then is easy to ill.When the people facing upward strongly fragrant, dejected, sad excellent stress environment in, humoral immunization and cellular immune function decreased also can be induced-helper T lymphocyte, suppressor T lymphocyte, T lymphocyte number obviously reduce.Body's immunity descend also be bring out one of sick factor of pool urine (" diabetes composite treatment " Haitao Liu, Feng Guangbin chief editor. Beijing: Maritime Press, the 101st page of 1998.5.).

Therefore three pathogenesis of diabetes are not that conventional medicine such as insulin can be removed, insulin taking stopgap measures of maintenance just in whole treatment of diseases process.

The basic concept of psychoneuroimmunology (Psychoneuroimmunology) is: activity, neural the exciting and immune playing a role of psychology, be inter-related, recognize and can attempt grasping and people itself is the easiest, it is exactly mental activity, psychoneuroimmunology is studied the new subject of " sensation " (psychology) to the immune system effect just, good " sensation " can make people's body be in good condition, and the while mental activity plays an important role in the overall process of the generation of disease and even elimination.

The method that obtains good psychology (sensation) has a lot, as: (1) talk imago method; (2) motion imago method; (3) the imago method of sitting quietly; (4) sensation imago method.First three kind is not that each patient can both accomplish, has only the 4th kind of natural fragrance in the sensation imago method to adjust that method (the fragrant treatment) is the easiest accomplishes or obtain, and the easiest patient of making produces comfortable sensation and positive phychology.Yet, how to allow the patient of wage-earners also can enjoy the fragrant achievement for the treatment of, how to allow fragrant the treatment cooperate medication to come into common people house, become the difficult point of problem.

Researcher of the present invention, in order to solve above-mentioned variety of issue, various compositionss are carried out repetition test, research, the discovery that the result is surprised, natural milk adds the natural aromatic spice with fragrant treatment effect, cooperate with pharmacological active substance and Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent additive, can solve above-mentioned various deficiency, thereby finish the present invention.Wherein, natural milk relies on its distinctive system to constitute the natural emulsified and suspending effect that is had, can substitute all non-natural surfactants, additive in the conventional formulation, can add an amount of phospholipid and derivant thereof in the time of if necessary, water soluble drug, fat-soluble medicine, insoluble drug are made emulsion-type, mixed suspension form and even lipid build solution, this solution packing can be obtained emulsion-type, mixed suspension form and even lipid build oral cavity, nasal-cavity administration spray; This solution promptly be can be made into the Foradil Aerolizer formoterol fumarate that can be used for oral cavity, nasal-cavity administration or makes the spray auxiliary agent after lyophilization or cryogenic vacuum spray drying make the compositions microsphereization; Also find also have the enzyme effect of pressing down behind the natural milk nasal-cavity administration in the preparation simultaneously, the effect of protection nasal mucosa, the PH cushioning effect, the osmotic pressure Accommodation is detained medicine and is prolonged the adhesive attraction of administration time and medicine is carried out emulsifying, solubilising, stable effect in nasal cavity, oral cavity; In addition, natural aromatic spice with fragrant treatment effect is when finishing it and improving the patients ' psychological status function, the discovery that we are also surprised: their great majority also have the function of natural drug penetration enhancer, the Natural antioxidant, natural antiseptic agent and antibacterial, can substitute all non-natural surfactants, additive in the conventional formulation, can add an amount of phospholipid and derivant thereof in the time of if necessary and unite use with it with auxiliary its drug osmotic promotion function.This point is that preparation of the present invention can be accomplished not have any non-natural additive and lays a good foundation.

The objective of the invention is to serve as theme when solving an above-mentioned difficult problem with natural milk, natural aromatic spice with fragrant treatment effect, the compositions of a kind of via intranasal application novel, that can not contain any non-natural additive, oral administration is provided and carrier, carrier-free Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent are arranged to society, make the patient that the sensation of a kind of security and back to nature be arranged when curing the disease; The present invention simultaneously also uses natural fragrance stimulates olfactory receptor cell, by corticocerebral excitement of medium influence and inhibition activity, improve patient's mental status, the balance vegetative nerve function, recover neurotransmitter, hormonal system and the immune system ability of body, cooperate medicine to reach the purpose of system's adjustment, treating both the principal and the secondary aspects of a disease at the same time from macroscopic view.

The compositions of per os of the present invention, nasal administration or Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent, it is characterized in that: it is to be formed by natural milk, natural aromatic spice, pharmacological active substance and Foradil Aerolizer formoterol fumarate with fragrant treatment effect, spray, spray auxiliary agent additive combination, and natural milk accounts for 0.1～99.999% of total composition; 0.001ppm～5% with natural aromatic perfumes comprise total composition of fragrant treatment effect.

The natural milk that uses among the present invention comprises: mammiferous milk, plant milk, and wherein mammal refers to all mammals, but based on milk that cattle, sheep, horse were produced; Plant milk is meant safe, nontoxic, can be made into all fabaceous seeds of natural Emulsion, made bean milk, the nut milk of kernel of edible nut-seed through processing.

The optional usefulness of using among the present invention of natural aromatic spice part with fragrant treatment effect has the plant essence oil of fragrant treatment effect and those can be used as medicine, food, the spice of cosmetics and highclass perfumes, correctives reaches to rectify smells the nontoxic of agent, single with or be used in combination that the people is produced is a kind of pure and fresh, happy, quiet, comfortable, the natural perfume material of relaxed and joyful sensation and the crude extract of natural perfume material, extract and the synthetic compound of deriving out by extract, the plant essence oil that wherein has fragrant treatment effect, the crude extract of natural perfume material and natural perfume material is including, but not limited to (hardship) Folium citri sinensis (Petitgrain bigarade and Paraguay) oil, Algeria Oleum Pelargonii Graveolentis Oil of Geranium Algerian, Herba Ardisiae Japonicae (Ardisia Leaf) oil, Tansy oil. Oil of Tansy, Folium Artemisiae Argyi (Artemisia argyi) oil, Benzoinum (Benzoin) oil, eucalyptus oil Oil of Eucalyptus, Australia Oleum Santali albi Oil of SandaIwoodAustralian, Fructus Anisi Stellati (Aniseed star) and Fructus Foeniculi (Anise) oil, Brazilian sassafras oil oil of BrazilianSassafras, Brazilian rosewood oil Oil of Bois de Rose Brazilian, Oil of sweet flag Oil of Calamus, cajeput oil oil of Cajeput, Pseudobulbus Bletillae (Rhizoma Bletillae) oil, Flos micheliae Albae oil Oil of Michelia Alba, Flower, Michelia leap oil Oil of Michelia Alba, Leaf, Radix Paeoniae Alba oil, Rhizoma Atractylodis Macrocephalae oil, common perilla oil, Radix Cynanchi Atrati oil, Radix Angelicae Dahuricae oil, thyme oil Oil of Thyme, the Oil of Cedar leaf of oil of cedar leaf, Cupressus funebris Endl. (Cedarwood) oil, oriental arborvitae seed oil, Rhizoma Pinelliae oil, Cortex Syringae oil, Radix Glehniae oil, Cubeb oil Oil of Cubeb, bouchi oil, oil of Semen Alpiniae Katsumadai, Fructus Tsaoko oil, tea tree oil Oil of Tea Tree, Rhizoma Atractylodis (Atractyllis) oil, Oleum Bupleuri, linaloe oil, Oleum Citri Reticulatae, Radix Paeoniae Rubra oil, Radix Vladimiriae oil, Rhizoma Chuanxiong oil, chamomile oil (Britain's type) Oil of Chamomile English Type, thorn bat oil Oil ofJuniper Berries, the sage oil Oil of Sage Dalmatian Type of Dalmatia, Oleum Bulbus Allii Oil ofGarlic, atlas cedarwood oil Oil of Cedarwood Atlas, turtle turtle leaf (Petitgrain Dai-dai) oil, Angelica root oil oil of Angelica Root, Angelica seed oil oil of Angelica Seed, Texas cedar wood oil oil ofCedarwood Texas, Virginia Cedar oil Oil of Cedarwood Virginia, seed oil of Herba Apii graveolentis Oil ofCelery Seed, Flos Caryophylli oil Oil of Clove Bud, clove-stems oil oil of Clove Stem, the Oil of Clove Leaf of Folium Caryophylli oil, green cognac Oil of Cognac Green, Ocimum Basilicum (Basil oil eugenoItype) oil, Oleum Caryophylli resin Oleoresin of Cloves, East Indian sandalwood oil Oil of sandalwood EastLndian, Ilicis Purpureae (Wintergreen) and Gaultheria forrestii (Gaultheria) oil, cardamom oil, doubleteeth pubescent angelica oil, oil of Herba Asari Forbesii, the Folium Rhododendri Simsii leaf oil, gin (Juniperberry) oil, Oleum Curcumae, Herba Centipedae oil, Lignum cinnamomi camphorae (Ho, 8hiu) oil, linalool (single from) Linalool (lsolated), verbena (Verbena) oil, opopanax oil Oil of Opopanax, hyacinth (Hyacinth) oil, the sweetgum fatty oil, Fructus Citri Sarcodactylis (Bergamot) oil, Linaloe oil Oil of Linaloe wood, JIANANXIANG oil, marjoram oil Oil of Marjoram Sweet, Radix Et Rhizoma Nardostachyos (Spikenard) oil, Rhizoma Alpiniae Officinarum oil, Rhizoma Ligustici oil, galbanum oil oil of Galbanum, Pueraria lobota thread (Caraway) seed oil, Cuba oil Oil of Copaiba, Flos Eriocauli oil, patchouli oil Oil of Patchouli, costus root oil Oil of Costus Root, Flos Osmanthi Fragrantis (Osmanthus) oil, castoreum (Castoreum), bashfully spend (silvery white Acacia farnesiana Willd.) (Mimosa) oil, Fructus piperis nigrum oil Oil of Black Pepper, black pepper oleoresin Oleoresin of Black Pepper, tonka beans (Tonka Bean) oil, Fructus Galangae oil, Cortex Magnoliae Officinalis oil, penner oil Oil of Pennyroyal, carrot-seed oil Oilof Carrot Seed, Herba Coriandri oil, amber oil, Radix seu folium abelmoschi moschati seed oil Oil of Ambrette Seed Liquid, acute seed oil, Fructus Tribuli oil, Canada Semen Abietis Delavayi oil oil of Fir NeedleCanadian, oleum abietis Oil of Fir Needle Siberian, Canadian snake root oil Oil of SnakerootCanadian, Rhizoma Zingiberis Recens pool resin Oleoresin of Ginger, Rhizoma Curcumae Longae oil resin Oleoresin of Tumeric, oil of ginger oil of Ginger, Rhizoma Zingiberis Recens grass (Gingergrass) oil, Lignum Dalbergiae Odoriferae oil, mentha piperita oil Oil of Mentha Piperita, Acacia farnesiana Willd. (Cassie) oil, lonicera oil, Herba Schizonepetae oil, rectification Eucalyptus globulus Labill leaf oil (Portugal) oil of EucatyptusGlobulus Labilllardiere Rectifled (Portugal), rectified oil of turpentine Oil of Turpentlne Rectified, Rhizoma Anemones Altaicae oil, oil of Folium Et Cacumen Murrayae, oil of Flos Chrysanthemi, tangerine oil, cananga oil oil of Cananga, cymin oil Oil ofCumin, Common Wormwood oil Oil of Wormwood, bigarabe flower (Neroli bigarade) and Citrus aurantium L. var. amara Engl. Oil, bitter orange oil Oilof Orange Bitter, Herba Corydalis Bungeanae oil, Semen Armeniacae Amarum oil oil of Bitter Almond FFPA, coltsfoot (Tussilaga) caul-fat, capsicum oleoresin Oleoresin of Capsicum, Herba Bidentis Tripartitae oil, cold grinding lemon rubber oil oil of Lemon ColdGrinded, oleum Citri sinensis Oil of Orange Sweet Cold Pressed colds pressing, oleum bergamottae (Italy) Oilof Bergamot Expressed (ltaly) colds pressing, bergamot approaches He (Bergamot Mint) oil, rectification birch tar oil Oil of BirchTar Rectifled, cold pressed lime oil Oil of Lime Cold Pressed, Fructus Forsythiae oil, Zibethum (Civet), Oleum Menthae Rotundifoliae Oil of Spearmint, Oleum Menthae Rotundifoliae (rectification) Oil of Spearmint RectifIed, stay Buddhist nun Wang Oleum Pelargonii Graveolentis Oil of Geranium Eeunion, dragon punt-pole oil oil of Estragon, Ambra Grisea (Ambergris or Ambra), basil oil (staying Buddhist nun Wang) Oil of Basil (Reunion), Herba Verbenae oil, Semen Capparis oil, horse Guerlain (Marjoram) oil, Herba Kalimeridis grass oil, Herba Verbenae (Vervain) oil, the wild pepper seed oil, Herba euphorbiae lunulatae oil, Myrrha Oil of Myrrh, Flos Rosae Rugosae (Rose) caul-fat, palmarosa oil Oil of Palmarosa, rose wood (Rosewood or Bois de Rose) oil, U.S. Chenopodium Oil Oil of Wormseed American, oil of rosemary Oil of Rosemary, Peru rosewood oil Oilof Bois de Rose Peruvian, Peru balsam oil Oil of Balsam Peru, Morocco Oleum Pelargonii Graveolentis Oil ofGeranium Moroccan, jasmine (Jasmin) oil, Herba Ecliptae oil, the Paeonia suffruticosa haze wax, Oleum Viticis Negundo, wooden slippers showy flowers of herbaceous plants (Reseda or Mignonette) oil, nanmu leaf (Machilus leaf) oil, eucalyptus citriodora oil Oil of EucalyptusCitriodora, Indian oil of verbena OH of Lemongrass, the oily Oil of Parsley Herb of parsley grass, the oily Oil of of parsley fruit (really) Parsley Seed, square-bottomed bamboo basket seed oil oil of Dill seed European is transplanted in Europe, oleum pini sylvestris Oil ofPinus Sylvestris, Herba Eupatorii Fortunei oil, hop oil Oil of Hops, Pollen Typhae oil, Rhizoma Homalomenae oil, peucedanum oil, incised notopterygium oil, oleoresin parsley Oleoresin of Celery, Herba Artemisiae Annuae oil, bluish yellow Elecampane oil (German type) Oil of ChamomileGerman Type, Pericarpium Citri Reticulatae Viride oil, ginseng oil, Semen Myristicae (Nutmeg) and Arillus Myristicae (Mace) oil, Arillus Myristicae oil Oil of Mace, Arillus Myristicae oleoresin Oleoresin of Mace, cinnamon leaf oil oil ofCinnamon leaf, Sri Lanka Cortex Cinnamomi leaf oil Oil of Cinnamon leaf Ceylon, Oleum Cinnamomi (China) oil of Cassia, China, Oleum Cinnamomi, Olibanum oil Oil of Olibanum, Seychelles Cortex Cinnamomi leaf oil oil of Cinnamon Leaf Seychelles, rhizoma sparganic oil, the Cortex Mori haze wax, Fructus Amomi oil, litsea cubeba oil Oil of Litsea Cubeba, Rhizoma Kaempferiae oil, Fructus Cnidii oil, Moschus (Musk).Oleum thymi vulgaris, Rhizoma Acori Graminei oil, Herba Gnaphalii Affinis (Gnaphalium) oil, oil of aglaia odorate Oil of Aglaiaodorata, Flower, Rhizoma Acori Calami oil, Herba Stachydis Japonicae oil, Herba Kyllingae oil, Flos Narcissi chinensis (Narcissus) and yellow fluid Shan flower (Jonquil) oil, Ceylon cinnamon bark oil oil of Cinnamon Bark Ceylon, Folium Pini (Pineneedle and Firneedle) oil, Storax oil Oil of Styrax, Lignum Sappan oil Tai Bay Red Juniper (Cypress Taiwan) oil, Lignum Santali Albi (Sandalwood) oil, Fructus Rhodomyrti Folium Lauri nobilis (Bay or Bay Leaf) oil, superfine Cananga odorata oil Oil of Ylang YlangExtra, natural Herba Menthae internal organs Menthol (Natural), paprike oleoresin Oleoresin of Paprika, sweet basil (Sweet basil) oil, Tolu balsam oil Oil of Tolu Balsam, Polianthes tuberosa L. (Tuberose) oil, Radix Clematidis oil, Fructus Gardeniae (Gardenta) caul-fat, lindera oil, the slender acanthopanax haze wax, Fructus Schisandrae oil, Spain Herba Origani oil Oil of Origanum, Spanish, Oil of Spanish sage Oil of Sage Spanish, Radix Panacis Quinquefolii oil, Oleum Asari, Spica Prunellae oil, Herba Agrimoniae oil, Herba Melissae officinalis (Melissa) oil, savory oil (summer variety) Oil of Savory (Summer Variety), Rhizoma Cyperi (Cyperus) oil, vetiver oil Oil of Vetiver, vanilla (Vanilla) Oleum Glycines, cascarilla Oil ofCascarilla, Herba Cymbopogonis Citrari (Citronella) oil, Andropogon nardus oil Oil of Citronella Ceylon, Herba Moslae oil, carnation (Carnation) oil, myrtus communis (Myrtle) oil, oil of geranium, Oleum Pelargonii Graveolentis Oil of Geranium, citron oil, Salvia Sclare L.oil Oil of Clary Sage, oak moss and tree moss (Oak Moss and Tree Moss) balsam and absolute oil, Cardamom oil oil of Cardamon, Fructus Foeniculi (Fennel) oil, oil of Rhizoma et radix valerianae Oil of Valerian, Flos Magnoliae oil, almond oil, Radix Dipsaci oil, Radix Scrophulariae oil, Oleum lavandula angustifolia Oil of Lavender, aspic oil Oil of lavenderSpike, squeezing tangerine oil Oil of Tangerine expressed, Arizona Fructus Citri Limoniae oil (cold pressing), Oil of LemonArizona Cold Pressed, asia peppermint vegetable oil Oil of Mentha Arvensis Partially Dementholized, coriander (Coriander) seed oil Yan Lan grass (Vettver) oil, labdanum oil oil of Labdanum, ocean GANJU (Camomiles), oil of Bulbus Allii Cepae Oil of Onion, Flos Matricariae chamomillae (Chamomile) oil, the Herba Dendranthematis indici caul-fat, Herba Eupatorii Lindleyani (Eupatorium) oil, Herba Solidaginis oil, fragrant cananga one Ka Nanjia (Ylang-Cananga) oil, oil of ylang ylang complete Oilof Ylang Ylang Complete, ylang ylang oil Oil of Ylang Ylang, Fructus Alpiniae Oxyphyllae oil, the Italy's Citrus chachiensis Hort. oil Oilof Mandarin ltaly big sharp permanent flower of Righteousness (Immortelle) oil, oil of Herba Artemisiae Scopariae, Herba Epimedii oil, silver fir oil Oilof Abies Alba, India dill seed oil oil of Dill Seed lndian, U.S. dill oil oil of DillweedAmerican, eucalyptus globolus (Eucalypus) oil, Stigma Maydis oil, Radix Curcumae oil, guaiac wood oil Oil ofGuaiacwood, orrisroot oil Oil of Orris Root, lovage oil Oil of Lovage, Oleum Citri grandis (squeezing) Oil of Grapefruit Expressed, laurel Oil of Bay Leaf, laurel Oil of Laurel Leaf, Radix Oenotherae erythrosepalae oil, hemlock oil Oil of Spruce, Herba Cymbopogonis oil Oil of Rue, lavandin oil Oil ofLavandin, lavandin oil (France) Oil of Lavandin Abrialis (France), eupatoria oil, Oleum Camphora Oil OfCamphor 1070, white camphor oil Oil of Camphor White 860-880, distilled lime oil Oil of LimeDistilled, distillation Fructus Citri Limoniae oil Oil of Lemon Distilled, distillation oleum Citri sinensis Oil of Orange Distilled, fat wingceltis oil Oil of Amyris, Aranea Oleum sesami, Fructus Aurantii oil, Fructus Aurantii Immaturus oil, China Guizhou Cedar oil Oil of CedarwoodGuizhou, China, middle Country Yu Lan caul-fat, pimento leaf oil Oil of Pimenta Leaf, Java citronella oil Oil ofCitronella Java Type, purple (in vain) Flos Caryophylli (Lilac) oil, violet leaf (Violet leaf) oil, Radix Asteris (Aster Root) oil; Wherein have fragrant treatment effect natural aromatic spice extract and by the synthetic compound that extract derives out comprise but not be limited to: (no chlorine) benzyl acetate; " nerone "; " fenxizisu "; " myrac aldehyde "; " the blue or green aldehyde of olive "; " lilestralis "; " jasmonyl "; " ligustral "; " bergamot aldehyde "; " LYRAL "; " strawberry aldehyde "; 1; the 8-cineole; 2; 6-dimethyl heptene-5-aldehyde-1; 2; 7; 8-front three basic ring 12 triolefins-2; 5; the 9-methyl ketone; the 2-ethyl is aldehyde ring second two acetals; 3; 3-Dimethylcyclohexyl methyl ketone; the 3-methylindole; 404 fixastive; 5-phenyl-5-methyl hexanone-3; the 6-methylquinoline; 6-methyl tetrahydroquinoline; N-methyl methyl 2-aminobenzoate; thymol; cedar wood alcohol; cedrenol; benzenpropanal; benzaldehyde; benzoic acid; benzoic acid-3-methyl butene-2-ester; benzyl benzoate; cinnamyl benzoate; essence of Niobe; ethyl benzoate; isobutyl benzoate; the positive butyl ester of benzoic acid; phenyl acetaldehyde dimethyl acetal; hyacinthin; phenylacetic acid; phenylethyl phenylacetate; p-cresyl phenylacetate; santalyl phenylacetate; geranyl phenyl acetate; ethyl phenylacetate; isobutyl phenylacetate; the positive butyl ester of phenylacetic acid; 1-Phenylethanone.; phenethyl ester; benzylalcohol; phenylethyl propionate; benzyl propionate; rhodinyl propionate; geranyl propionate; ethyl propionate; isoamyl propionate; third phenylpropanol; third in oneself; third nonalactone; third undecalactone; third caprylolactone; Mentholum; menthone; nerol; nerolidol; anisyl alcohol; anisic aldehyde; diacetyl; benzyl butyrate; butyl butyrate; amyl butyrate and isoamyl butyrate; geranyl butyrate; ethyl n-butyrate.; eugenol; eugenol methyl ether; methyl para-cresol; melilotal; acetanisole; para hydroxybenzene ethyl-methyl ketone; to ethyl-first position; first position-dimethyl benzene propionic aldehyde; benzophenone; diphenyl-methane; diphenyl ether; musk xylene; dimethyl benzyl carbinol; dimethyl is for hydroquinone; dihydro jasmone; MDJ; dihydromyrcenol; trans-anethole; linalool; phantolid; Eucarvone; heptyne hydroxy acid methyl ester; cognac oil; cinnamic alcohol; methyl decine-carbonate; cinnamic acid; phenyl ethyl cinnamate; benzyl cinnamate; cinnamyl cinnamate; the cinnamic acid methyl ester; ethyl cinnamate; isobutyl cinnamate; pentadacanolide; cyclopentadecanone; safrole; allyl hexanoate; ethyl hexanoate; methyl Cupressus funebris Endl. base ether; methyl nonyl acetaldehyde; methyl octyl acetaldehyde; methyl second position naphthyl ketone; methyl n-hexyl ketone; the methyl n-nonyl ketone; methyl-n-amyl ketone; methyl ionone; cedryl formate; phenyl ethyl formate; benzyl formate; linalyl formate; rhodinyl formate; citronellyl formate; geranyl formate; Ethyl formate; isoamyl formate and amyl formate; the formic acid n-octyl; the first position; first position one dimethyl phenylethyl carbinol; first position cedroxyde; first position amyl group is hung alcohol; alpha-amyl cinnamic aldehyde; first position base hangs aldehyde; rosalin; farnesol; musk ambrette; linalyl anthranilate; ortho-aminobenzoic acid first position Oleum Pini ester; methyl 2-aminobenzoate; cibetone; Borneolum Syntheticum; Ambergris ether; maltol; rhodinol; rose oxide; methyl jasmonate; interior undecylene aldehyde; limonene; lemonile; citral; citral diethyl acetal; pinene; hydroxycitronellal; the sandalidol; nonadiene-2; 6-aldehyde; the n-nonanoic acid phenethyl ester; ethyl pelargonate; cinnamic aldehyde; celestolide; tricyclic isochroman musk; the trimethylbenzene Moschus; Moschus moschiferous certain herbaceous plants with big flowers lactone; Moschus 105; astrotone; the Moschus hydrocarbon; muscone; lauronitrile; Fructus anethi aldehyde; the salicylic acid phenethyl ester; the salicylic acid ethyl ester; benzyl salicylate; methyl salicylate; isoamyl salicylate; cis n-hexylene-3-alcohol; tetramethyl octahydro naphthyl ketone; tetramethyl acetyl group octahydro naphthalene; tetrahydrogeraniol; terpineol; santalol; musk ketone; cyclamen aldehyde; coumarin; carvacrol; vanillin; citronellol; 3,7-Dimethyl-6-octenenitrile; citronellal; geraniol; sclareol; Nitrobenzol; octyne hydroxy acid methyl ester; ethyl caprilate; bromostyrene; nitrous ether (ethyl nitrite); vetiverol; heliotropin; second changes the former ester of dimethyl benzene ethyl; second changes the former pound of dimethyl grandfather base; ethyl vanillin; acetic acid-2-tert-butyl group cyclohexyl; Cedryl acetate.; phenethyl acetate; cassie ketone; butyl acetate; narceol; linalyl acetate; cinnamyl acetate; borneol acetate; rhodinyl acetate; nopyl acetate; Tricyclodecenyl acetate; terpinenyl aceatae; methyl phenyl carbinyl acetate; santalyl acetate; citronellyl acetate; geranyl acetate; vetacetyl; acetic acid second position decahydronaphthalene ester; ethyl acetate; isoamyl acetate; myrcenyl acetate; acetic acid ester in the positive last of the ten Heavenly stems; n-nonyl acetate; the acetic acid n-octyl; second position phenethanol; neroline bromelia; second position naphthol ethyl ether; acetyl cedrene; acetyl iso-eugenol; ethyl acetoacetate; isopropyl indane Moschus; isolongitolanone; isoeugenol; the isoeugenol benzylic ether; the isoeugenol methyl ether; isocyclocitral; isosafrole; isojasmone acid methyl ester; phenylethyl isovalerate; ethyl isovalerate; iso-amyl iso-valeriate; indole; irone; myrcenol; n-butyric acie; n-butyric acie Flos Rosae Rugosae ester; positive dibutyl sulfide; n-heptanol; Decanol; n-capric aldehyde; hexanol; n-nonyl alcohol; n-nonyl aldehyde; n-dodecanol; positive lauric aldehyde; positive undecyl alcohol; n-undecylic aldehyde; positive hendecene-10-alcohol-1; positive hendecene-10-aldehyde-1; positive glutaconic nitrile and isovaleric acid geraniol ester; n-octyl alcohol; n-octaldehyde; ionoionone more preferably has the plant essence oil of fragrant treatment effect.

The pharmacological active substance that uses among the present invention, do not limit to Chinese medicine, Western medicine, as long as water-soluble medicine, liposoluble medicine, insoluble medicine can at nasal mucosa or work in the oral mucosa part or the pharmacological component that can absorb by nasal mucosa or oral mucosa, can use; Especially the high and oral medicine that can not absorb fully of the medicine that liver first-pass effect is big, water solublity, decompose significant medicine at digestive tract, and those need and can to see through the medicine etc. of blood brain barrier by nasal cavity more suitable; Its consumption is that usual amounts (conventional amount used of medicine in nasal drop, eye drop, spray, Foradil Aerolizer formoterol fumarate and injection) is not done particular determination.

Particularly:

Topical and to the Western medicine of brain administration including, but not limited to: antibiotic medicine, antiallergic agent, antipyretic analgesic, central stimulants, analgesic, antiparkinsonian drug, Psychotolytic, antuepileptic, tranquilizer, hypnotic, anticonvulsant, intracranial pressing, anti-cerebral tumor medicine, anti-ageing year dementia medicine fall; Chinese medicine can select for use those to have classes such as relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, resolving heat and reducing pathogenic fire, heat-clearing and toxic substances removing, clearing away heat and cooling blood, suppressing the hyperactive liver to relieve the wind syndrome (seeing that remarks 1 exemplify) Chinese herbal medicine, according to conventional method use separately or with the other drug prescription, after extracting, making with extra care, add in the compositions of above-mentioned nasal cavity, oral administration again.

Inferior topical, under the prerequisite of not repelling any respiratory system commonly used, blood circulation Western medicine, can select class (seeing that remarks 2 exemplify) Chinese herbal medicine such as those have relieving cough and asthma, regulate the flow of vital energy, causing resuscitation with aromatic drugs, blood circulation promoting and blood stasis dispelling for use, according to conventional method use separately or with the other drug prescription, after extracting, making with extra care, add in the compositions of above-mentioned nasal cavity, oral administration again.

The whole body administration, mainly be meant non-peptide, nonprotein medicine and polypeptide, protein drug, the vaccine medicine, wherein non-peptide, the nonprotein drug main will comprise anti-inflammatory steroid chemical compound or nonsteroidal anti-inflammatory drug, the antalgic and inflammation relieving agent, antisussive and expectorant agent, antihistaminic, antiallergic agent, Bendectin, sleeping pill, vitamin preparation, steroid hormone, antitumor drug, anti-arrhythmic agents, antihypertensive drug, anxiolytic drugs, influence the medicine of spirit, the antiulcer medicine, cardiac tonic, analgesics, bronchodilator, the Bariatric agent, antithrombotic drug, antidiabetic drug, muscle relaxant, antirheumatic; Polypeptide, protein drug, vaccine mainly comprises insulin, glucagon and derivant thereof, the C-peptide of insulin, vasopressin, Desmopressin, thyroliberin and derivant thereof, corticotropin releasing hormone, the bradykinin derivant, gonadotropin-releasing hormone, gonadotropin-releasing hormone agonist and antagonist, the gonadotropin lutropin, calcitonin, gastrin, parathyroid hormone, secretin, luteotrophic hormone, short luteotrophic hormone releasing hormone, nerve growth factor and releasing factor thereof, angiotensin, melanotropin, growth hormone, growth hormone releasing hormone and derivant thereof, somatostatin, vassopressin, the anterior chamber urgees the natruresis polypeptide derivative, neurotensin, cholecystokinin, interior non-peptide, brain method peptide, oxytocin, the Hirudo hormone derivative, atrial natriuretic peptide, short first shape hormone releasing hormone, deoxyribonuclease, stimulate macrophage to form the factor, prolactin antagonist, follitropin, granulocyte colony-stimulating factor, erythropoietin, biological activity proteins such as epidermal growth factor interferon and interleukin, superoxide dismutase and derivant thereof, renin, vasoactive intestinal peptide, muramyl peptide dipeptides, and above-mentioned analog; The vaccine medicine is including, but not limited to vaccine following and infection and immune diseases related, the viral infectious vaccine, thin mattress sexually transmitted disease vaccine: influenza, common cold, measles, rubella, chickenpox, epidemic encephalitis type B, rabies, cancer, acquired immune deficiency syndrome (AIDS), viral hepatitis, spirochetal icterus, mumps, poliomyelitis, diphtheria, hemolytic streptococcal infection, staphy lococcus infection, epidemic cerebrospinal meningitis, bacterial meningitis, pertussis, cholera, typhoid fever and paratyphoid fever, bacillary dysentery, coliform diarrhea, tetanus, anthrax, the plague, leprosy, the syphilis vaccine, and can select for use natural complex microorganism through deactivation, cracking, refining gained such as means such as vaccine such as grade: combination vaccine, compound vaccine, the complex class toxin, the composite bacterial element, composite antibiotic, wherein one or more such as compound short-chain fatty acid combine the compound bio compositions

In addition; in any via intranasal application; the oral administration Foradil Aerolizer formoterol fumarate; spray; in the spray auxiliary agent; generally as Foradil Aerolizer formoterol fumarate; spray; spray auxiliary agent additive; can be as required; it is commonly used to choose those wantonly; pharmaceutically acceptable carrier granular; diluent; solvent; the latent solvent matchmaker; emulsifying agent; solubilizing agent; pharmaceutical penetration enhancer; adhesive agent; the nasal mucosa protective agent; controlled release agent; slow releasing agent; enzyme inhibitor; correctives; lubricant; stabilizing agent; antibacterial; antiseptic; antioxidants etc. are not when repelling the non-natural additive; select natural additive for use or with natural milk with identical function as far as possible; natural aromatic spice with fragrant treatment effect; phospholipid and derivant thereof substitute; because above-mentioned additive is common by industry; its kind; consumption suitably cooperates by demand, there is no other restriction.

Wherein as per os, nasal administration Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent compositions core component when preparation Foradil Aerolizer formoterol fumarate, spray, the spray auxiliary agent, can each component be inserted this Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent by following combination:

(1) one or more natural milk

(2) one or more have the natural aromatic spice of fragrant treatment effect

(3) zero kind, one or more pharmacological active substancies,

Then the needs that constitute according to compositions add Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent additive:

(4) zero kind, one or more solvents, latent solvent matchmaker,

(5) zero kind, one or more solubilizing agents,

(6) zero kind, one or more emulsifying agents

(7) zero kind, one or more pharmaceutical penetration enhancers

(8) zero kind, one or more enzyme inhibitors,

(9) zero kind, one or more nasal mucosa protective agents,

(10) zero kind, one or more adhesive agents,

(11) zero kind, one or more slow releasing agents, controlled release agent,

(12) zero kind, one or more antiseptic,

(13) zero kind, one or more correctivess,

(14) zero kind, one or more antioxidants,

(15) zero kind, one or more stabilizing agents,

(16) zero kind, one or more carriers,

(17) zero kind, one or more diluent,

(18) zero kind, one or more lubricants,

L is described, when (3) pharmacological active substance is chosen as " zero ", more approach pure fragrant the treatment this moment, can be used for the maintenance of excitating organism immunocompetence, local mucous membrane and the topical therapeutic of a part of local disease, at this moment, the function of natural aromatic combinations of perfumes that zero kind, one or more natural milk and one or more have fragrant treatment effect is enough.

Illustrate 2, when being chosen as in (16) " zero ", then this Foradil Aerolizer formoterol fumarate is: the carrier-free Foradil Aerolizer formoterol fumarate of per os, nasal administration, its advantage is: the lotus pharmaceutical quantities is big, the emptying performance is good, the secondary deposition is high, the permeable membrane rate is good etc.

Illustrate 3, when one in (4)～(18) or multinomial being chosen as " zero ", have two kinds may: when 1. constituting certain compositions, do not need certain or certain several additive; 2. in this compositions, the function of certain or certain several additive can be substituted by one or more natural milk and one or more expanding functions with natural aromatic spice of fragrant treatment effect.

Illustrate 4, each Foradil Aerolizer formoterol fumarate, spray, the spray auxiliary agent all should be made has the Foradil Aerolizer formoterol fumarate distinct fragrance breath, different-style, spray, spray auxiliary agent more than three kinds, with the preference that adapts to different patients and prevent the olfactory fatigue that the single fragrant breath of life-time service is caused, and influence the actual effect that preparation excites immunocompetence.

Preparation method:

1, the preparation of carrier-free Foradil Aerolizer formoterol fumarate is by above-mentioned natural milk, the natural aromatic spice with fragrant treatment effect, pharmacological active substance, Foradil Aerolizer formoterol fumarate additive and proportioning thereof, preparation by active particle, additional particulates, mix, several procedures such as packing are finished; Wherein the preparation method of active particle is: natural milk, the natural aromatic spice with fragrant treatment effect, pharmacological active substance and required Foradil Aerolizer formoterol fumarate additive are prepared from by operations such as mix homogeneously, homogenizing, cryogenic vacuum spray drying (or lyophilization, pulverizing), it is characterized in that: when Foradil Aerolizer formoterol fumarate is pulmonary administration, the particle diameter of active particle should be controlled at below the 20 μ m, preferred 0.1～10 μ m, more preferably 0.5～7 μ m; When Foradil Aerolizer formoterol fumarate was nasal cavity, oral administration, the particle diameter of active particle should be controlled at below the 350 μ m, preferred 10～100 μ m, more preferably 30～50 μ m; If (the high molecular slow-release material can use separately or unite use with natural milk to have added the high molecular slow-release material in the liquid of active particle before spray drying, and the skeleton thing of formation active particle), this moment, the active particle of gained had slow release effect: the Foradil Aerolizer formoterol fumarate of gained gets final product quick-acting emergencies and also have slow-release function after general active particle and slow release active particle make up by a certain percentage, so become long-acting Foradil Aerolizer formoterol fumarate; The control of active particle particle diameter: by lyophilization, the prepared active particle of comminuting method, the size of its particle diameter is controlled by pulverizing process; By the prepared active particle of cryogenic vacuum spray drying method, the size of its particle diameter is by two procedures controls such as the concentration of adjusting the mixed liquor before the spray drying, atomisation pressures; Wherein additional particulates mainly is meant the micro powder granule of lubricant.

2, the preparation of carrier dry powder inhalant being arranged is by above-mentioned natural milk, the natural aromatic spice with fragrant treatment effect, pharmacological active substance, Foradil Aerolizer formoterol fumarate additive and proportioning thereof, preparation by active particle, carrier granular, additional particulates, mix, several procedures such as packing are finished; The preparation method of active particle and last with no longer repeatedly stating wherein; The particle diameter of carrier granular should be controlled at below the 1000 μ m, preferred 20～350 μ m, more preferably 70～100 μ m; Wherein additional particulates mainly is meant the micro powder granule of lubricant.

3, the preparation of spray is by above-mentioned natural milk, the natural aromatic spice with fragrant treatment effect, pharmacological active substance, spray additive and proportioning thereof, finishes by several procedures such as batching, adjustment, homogenizing processing, sterilization, packing.

4, the spray auxiliary agent is by above-mentioned natural milk, the natural aromatic spice with fragrant treatment effect, pharmacological active substance, spray auxiliary agent additive, by batching, adjustment, homogenizing handle, sterilization, dry and then with dried powder branch make any dissolved easily and easily sealing several procedures such as solid auxiliary agent of preserving finish.Wherein, drying preferably adopts lyophilization, cryogenic vacuum spray drying.

The invention has the advantages that: serve as theme with natural milk and natural aromatic spice with fragrant treatment effect, proposition has carrier, the carrier-free Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent compositions, Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent and preparation method thereof, preparation is not only existed: have aspect the natural aromatic breath, can not contain any non-natural additive aspect, make the patient that the sensation aspect of back to nature be arranged, reduce nose zest aspect, and the lotus pharmaceutical quantities is big, the emptying performance is good, the secondary deposition is high, aspects such as permeable membrane function admirable are contributed to some extent to pharmaceutics; And be psychoneuroimmunology, fragrant iatreusiology, three interdisciplinary organic assembling such as iamatology, this dry powder inhalant, spray, after the administration of spray auxiliary agent, its natural fragrance stimulates olfactory receptor cell, by corticocerebral excitement of medium influence and inhibition activity, the mental status that improves the patient (produces a kind of pure and fresh immediately, happy, comfortable, quiet, relaxed and joyful sensation), the balance vegetative nerve function, recover the neurotransmitter of body, hormonal system and immune system ability cooperate medicine to reach system's adjustment from macroscopic view, the purpose for the treatment of both the principal and the secondary aspects of a disease at the same time.In addition, the form that the present invention also borrows spray to help auxiliary agent (solid preparation) reaches and improves the chemistry of spray in shelf time, the purpose of bio-stable.

The present invention be particularly suitable for flu, asthma, angina pectoris, diabetes insulin nasal cavity, oral cavity, pulmonary administration and by nasal cavity to the brain administration.

In order to further specify the present invention, but not limited provide following embodiment:

Embodiment 1: clear key SHUANGHUANLIAN Foradil Aerolizer formoterol fumarate

Prescription:

Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae (SHUANGHUANLIAN) powder pin level extract 40g

Oleum menthae 0.6g Oleum thymi vulgaris 0.4g Salvia Sclare L.oil 0.6g

The bright skim milk 1600ml of fabaceous lecithin 10g cyclamate 10g

Distilled water 100ml magnesium stearate 4g

Preparation method:

Get fully stir in the distilled water that shuanghuanglian powder injection level extract, cyclamate add 100ml make it to dissolve standby; With Oleum menthae, Salvia Sclare L.oil, Oleum thymi vulgaris add sterilization back and vacuum concentration to the fresh skim milk of about original volume 1/2 fully stirring volatile oil is entered in the emulsion droplet of milk, above-mentioned SHUANGHUANLIAN mixed liquor is added mix homogeneously in the milk mixed liquor under well-beaten condition, and under well-beaten condition, the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly, add and carry out the short reason of homogenizing in the dispersing emulsification machine, the cryogenic vacuum spray drying, with dry gained powder and magnesium stearate mix homogeneously, be sub-packed in 10000 capsules and pack Hou with PTP, the aluminum bag of packing into gets final product.

Embodiment 2: clear key SHUANGHUANLIAN spray

Prescription:

Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae (SHUANGHUANLIAN) powder pin level extract 10g

Oleum menthae 0.2g Oleum thymi vulgaris 0.1g Salvia Sclare L.oil 0.2g

The fresh skim milk 300ml of fabaceous lecithin 10g cyclamate 3g

It is 1000ml that distilled water makes cumulative volume in right amount

Preparation method:

Get shuanghuanglian powder injection level extract, after fully stirring makes it the dissolving sterilization in the distilled water of cyclamate adding 660ml, with Oleum menthae, Oleum thymi vulgaris, Salvia Sclare L.oil adds fully to stir in the fresh skim milk under fully stirring enters in the emulsion droplet of milk volatile oil, above-mentioned SHUANGHUANLIAN mixed liquor is added mix homogeneously in the milk mixed liquor under well-beaten condition, and under well-beaten condition, the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly, add and carry out the short reason of homogenizing in the dispersing emulsification machine, it is the 1000ml mix homogeneously that adding distil water makes the medicinal liquid cumulative volume in right amount, be sub-packed in 100 aerosol containers and get final product.

Embodiment 3: clear key SHUANGHUANLIAN spray auxiliary agent (powder, powder, granule, tablet, capsule ...)

Prescription:

Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae (SHUANGHUANLIAN) powder pin level extract 10g

Oleum menthae 0.6g Oleum thymi vulgaris 0.3g Salvia Sclare L.oil 0.2g

Fabaceous lecithin 10g cyclamate 3g nisin 0.15g

Fresh skim milk 400ml distilled water 50ml

Preparation method:

Get fully stir in the distilled water that shuanghuanglian powder injection level extract, cyclamate, nisin add 50ml make it to dissolve standby; Fully stirring in the fresh Coconut milk with Oleum menthae, Oleum thymi vulgaris, Salvia Sclare L.oil adding sterilization enters in the emulsion droplet of milk volatile oil, above-mentioned SHUANGHUANLIAN mixed liquor is added in the bright Coconut milk mixed liquor mix homogeneously and under well-beaten condition the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly under well-beaten condition, add dispersing emulsification machine carry out the short reason of homogenizing, again after the cryogenic vacuum spray drying, divide the solid preparation of making 100 dosage to get final product.

During use, in the content adding aerosol container with solid preparation or solid preparation, add pure water 10ml, shake well can use after making it to dissolve fully.

Embodiment 4: insulin nasal cavity, oral cavity Foradil Aerolizer formoterol fumarate

Insulin 60000U fabaceous lecithin 10g ginseng oil 0.2g eucalyptus globolus oil 0.6g

The fresh skim milk 2000ml of Fructus Citri Limoniae oil 0.4g

Distilled water 20ml magnesium stearate 4g

Preparation method:

Get continue to stir in insulin adds 20ml under fully stirring the distilled water make it to dissolve standby; With ginseng oil, eucalyptus globolus oil, Fructus Citri Limoniae oil add sterilization back and vacuum concentration to the fresh skim milk of about original volume 1/3 fully stirring volatile oil is entered in the emulsion droplet of milk, above-mentioned insulin mixture is added mix homogeneously in the milk mixed liquor under fully stirring, and under well-beaten condition, the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly, add carry out the short reason of homogenizing, cryogenic vacuum spray drying in the dispersing emulsification machine, with dry gained powder and magnesium stearate mix homogeneously, be sub-packed in 10000 capsules and pack Hou with PTP, the aluminum bag of packing into gets final product.

Embodiment 5: insulin nasal cavity, oral spray

Insulin 6000U～200000U fabaceous lecithin 10g ginseng oil 0.15g Fructus Citri Limoniae oil 0.2g

Eucalyptus globolus oil 0.3g cyclamate 3g nisin 0.1g

Fresh Coconut milk 500ml distilled water adds to 1000ml

Get continue to stir in insulin, cyclamate, nisin add 480ml under fully stirring the distilled water make it to dissolve standby; Fully stirring in the fresh Coconut milk with ginseng oil, Fructus Citri Limoniae oil, eucalyptus globolus oil adding sterilization enters in the emulsion droplet of milk volatile oil, above-mentioned insulin mixture is added mix homogeneously in the bright Coconut milk mixed liquor under fully stirring, and under well-beaten condition, the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly, it is the 1000ml mix homogeneously that adding distil water makes the medicinal liquid cumulative volume in right amount, add dispersing emulsification machine carry out the short reason of homogenizing, again after sterilizing, be sub-packed in 100 aerosol containers and get final product.

Embodiment 6: insulin nasal cavity, oral spray auxiliary agent

Insulin 6000U～200000U fabaceous lecithin 10g ginseng oil 0.2g Fructus Citri Limoniae oil 0.2g

Eucalyptus globolus oil 0.3g cyclamate 3g nisin 0.15g

Fresh skim milk 500ml distilled water 50～100ml

Get continue to stir in insulin, cyclamate, nisin add 50～100ml under fully stirring the distilled water make it to dissolve standby; Fully stirring in the fresh skim milk with ginseng oil, Fructus Citri Limoniae oil, eucalyptus globolus oil adding sterilization enters in the emulsion droplet of milk volatile oil, above-mentioned insulin mixture is added mix homogeneously in the milk mixed liquor under fully stirring, and under well-beaten condition, the fabaceous lecithin powder added slowly mix homogeneously in the above-mentioned mixed liquor, add dispersing emulsification machine carry out the short reason of homogenizing, again after the cryogenic vacuum spray drying, divide the solid preparation of making 100 dosage to get final product.

During use, in the content adding aerosol container with solid preparation or solid preparation, add pure water 10ml, shake well can use after making it to dissolve fully.

Illustrate: the insulin prescription is measured 6000U～200000U in above-mentioned two examples, and purpose is to be adapted to the patient of the different state of an illness.

Embodiment 7: the albuterol Foradil Aerolizer formoterol fumarate

Albuterol 4g Oleum menthae 0.4g

Oleum lavandula angustifolia 0.8g Herba Cymbopogonis oil 0.8g

Fresh skim milk 2000ml ethanol 20ml

Leucine 5g

Preparation method:

Get continue to stir in albuterol, Oleum menthae, Oleum lavandula angustifolia, Herba Cymbopogonis oil add 20ml under fully stirring the ethanol make it to dissolve standby, with continuing to stir in the above-mentioned albuterol mixed liquor fresh skim milk that slowly adding is sterilized under abundant stirring condition volatile oil is entered in the emulsion droplet of milk, add carry out the short reason of homogenizing, cryogenic vacuum spray drying in the dispersing emulsification machine, with dry gained powder and leucine mix homogeneously, be sub-packed in 10000 capsules and pack Hou with PTP, the aluminum bag of packing into gets final product.

Embodiment 8: long-acting albuterol Foradil Aerolizer formoterol fumarate

Prescription 1:

Albuterol 2g Oleum menthae 0.2g

Oleum lavandula angustifolia 0.4g Herba Cymbopogonis oil 0.4g

Fresh skim milk 1000ml ethanol 20ml

Prescription 2:

Salbutamol sulfate 4g Oleum menthae 0.2g

Oleum lavandula angustifolia 0.4g Herba Cymbopogonis oil 0.4g

Fresh skim milk 1000ml sodium carboxymethyl cellulose 10g

Distilled water 200ml leucine 5g

Preparation method:

Get continue to stir in albuterol, Oleum menthae, Oleum lavandula angustifolia, Herba Cymbopogonis oil in the prescription 1 add 20ml under fully stirring the ethanol make it to dissolve standby, above-mentioned albuterol mixed liquor is slowly added continue to stir in the fresh skim milk of sterilization under abundant stirring condition volatile oil is entered in the emulsion droplet of milk, add carry out the short reason of homogenizing in the dispersing emulsification machine, that the cryogenic vacuum spray drying gets powder 1 is standby.

Get continue to stir in salbutamol sulfate, sodium carboxymethyl cellulose in the prescription 2 add 200ml under fully stirring the distilled water make it to dissolve standby; Fully stirring in the fresh skim milk with Oleum menthae, Oleum lavandula angustifolia, Herba Cymbopogonis oil adding sterilization enters in the emulsion droplet of milk volatile oil, above-mentioned salbutamol sulfate mixed liquor is added mix homogeneously in the milk mixed liquor under fully stirring, add carry out in the dispersing emulsification machine the short reason of homogenizing, cryogenic vacuum spray drying get powder 2 standby, with the powder 2 and the leucine mix homogeneously of the powder 1 of above-mentioned prescription 1 gained, prescription 2 gained, be sub-packed in 10000 capsules with PTP packing Hou, the aluminum bag of packing into gets final product.

Embodiment 9: Su Bing nasal cavity, oral cavity Foradil Aerolizer formoterol fumarate

Styrax 15g Borneolum Syntheticum 30g Oleum menthae 0.8g

JIANANXIANG oil 0.8g fabaceous lecithin 10g ethanol 50ml

Fresh skim milk 2000ml Pulvis Talci 4g

Get styrax, Borneolum Syntheticum, Oleum menthae, JIANANXIANG oil under agitation add make it in the alcoholic solution to dissolve standby, with above-mentioned standby mixed solution under well-beaten condition, add sterilization back and vacuum concentration to the fresh skim milk of about original volume 1/3 fully stirring volatile oil is entered in the emulsion droplet of milk, and under well-beaten condition, the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly, add and carry out the short reason of homogenizing in the dispersing emulsification machine, the cryogenic vacuum spray drying, with dry gained powder and Pulvis Talci mix homogeneously, be sub-packed in 10000 capsules and pack Hou with PTP, the aluminum bag of packing into gets final product.

Embodiment 10: Su Bing nasal cavity, oral spray

Styrax 10g Borneolum Syntheticum 20g Oleum menthae 0.6g

Oleum lavandula angustifolia 0.3g cyclamate 3g

Fabaceous lecithin 10g nisin 0.1g ethanol 50ml

Fresh skim milk 600ml distilled water adds to 1000ml

Get styrax, Borneolum Syntheticum, Oleum menthae, Oleum lavandula angustifolia under agitation add make it in the alcoholic solution to dissolve standby, cyclamate, nisin under fully stirring, add continue to stir in the distilled water of 300ml make it to dissolve standby; Above-mentioned two kinds of standby mixed solutions being added fully stir in the fresh skim milk of sterilization under well-beaten condition enters in the emulsion droplet of milk volatile oil, and under well-beaten condition, the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly, it is the 1000ml mix homogeneously that adding distil water makes the medicinal liquid cumulative volume in right amount, add dispersing emulsification machine carry out the short reason of homogenizing, again after sterilizing, be sub-packed in 100 aerosol containers and get final product.

Embodiment 11: the Alprazolam nasal Foradil Aerolizer formoterol fumarate

Prescription:

Alprazolam 3g Oleum menthae 0.8g Oleum thymi vulgaris 0.5g

Fabaceous lecithin 10g ethanol 50ml

Fresh skim milk 1000ml magnesium stearate 2g

Preparation method:

Get alprazolam, Oleum menthae, Oleum thymi vulgaris under well-beaten condition, add make it to dissolve in the alcoholic solution standby, with above-mentioned standby mixed solution under well-beaten condition, add sterilization back and vacuum concentration to the fresh skim milk of about original volume 1/3 fully stirring make medicine, volatile oil enters in the emulsion droplet of milk, and under well-beaten condition, the fabaceous lecithin powder is added mix homogeneously in the above-mentioned mixed liquor slowly, add and carry out the short reason of homogenizing in the dispersing emulsification machine, the cryogenic vacuum spray drying, with dry gained powder and magnesium stearate mix homogeneously, be sub-packed in 10000 capsules and pack Hou with PTP, the aluminum bag of packing into gets final product.

Embodiment 12: the alprazolam nasal spray

Prescription:

Alprazolam 3g Oleum menthae 0.4g Oleum thymi vulgaris 0.2g

Cyclamate 3g nisin 0.1g ethanol 50ml

New fresh soyabean milk 500ml distilled water adds to 1000ml

Preparation method:

Get alprazolam, Oleum menthae, Oleum thymi vulgaris under well-beaten condition, add make it to dissolve in the alcoholic solution standby, cyclamate, nisin add fully stir in the distilled water of 400ml make it to dissolve standby; Above-mentioned two kinds of standby mixed solutions being added fully stir in the new fresh soyabean milk of sterilization under well-beaten condition enters in the emulsion droplet of bean milk medicine, volatile oil, and under well-beaten condition with above-mentioned mixed liquor in mix homogeneously, it is the 1000ml mix homogeneously that adding distil water makes the medicinal liquid cumulative volume in right amount, add dispersing emulsification machine carry out the short reason of homogenizing, again after sterilizing, be sub-packed in 100 aerosol containers and get final product.

Remarks 1: Herba Ephedrae; Ramulus Cinnamomi; Folium Perillae; common perilla; Herba Schizonepetae; Radix Saposhnikoviae; the Radix Angelicae Dahuricae; Herba Asari; Herba Asari Forbesii; Flos Magnoliae; Rhizoma Zingiberis Recens; very light blue; Herba Moslae; Cacumen Tamaricis; Rhizoma Ligustici; Fructus Xanthii; Radix Caesalpiniae Radicis; Herba Adenosmae; the lamp-stand Herba Asari; Herba Centipedae; Herba Thymi; Herba Stachydis Japonicae; Herba Menthae; Adeps Bovis seu Bubali; Fructus Arctii; Flos Chrysanthemi; Folium Mori; Periostracum Cicadae; talk Semen Sojae Preparatum; Fructus Viticis; the Herba Equiseti Hiemalis; Herba Spirodelae; Radix Bupleuri; Herba Solidaginis; Herba Inulae cappae; Herba Peristrophes; Radix Scutellariae; Rhizoma Coptidis; Gypsum Fibrosum; Mirabilitum crystallina; the Rhizoma Anemarrhenae; Folium Pleioblasti; Rhizoma Phragmitis; Caulis Bambusae In Taenia; Fructus Gardeniae; Spica Prunellae; Plumula Nelumbinis; Semen Cassiae; Semen Celosiae; Flos Eriocauli; Flos Buddlejae; Radix Berberidis; Calculus Bovis; Fel Ursi; bile; Fel Serpentis; Flos Chrysanthemi Indici; Flos Lonicerae; Caulis Lonicerae; Fructus Forsythiae; Semen Sterculiae Lychnophorae; Herba Taraxaci; Herba Corydalis Bungeanae; Herba Sonchi Arvensis; Herba Patriniae; Herba Houttuyniae; Radix Isatidis; Folium Isatidis; Folium Polygoni Tinctorii; Indigo Naturalis; Radix Sophorae Tonkinensis; Rhizoma Menispermi; Lasiosphaera Seu Calvatia; Rhizoma Belamcandae; Rabdosia rubescens; Herba Andrographis; Radix Stephaniae Cepharanthae; Rhizoma Dioscoreae Bulbiferae; Herba Commelinae; Radix Zanthoxyli; Ilex purpurea Hassk.[I.chinensis Sims; Herba Duchesneae Indicae; Fructus Adinae; Herba Sarcandrae; Radix Tinosporae; Flos Trollii; Caulis Fibraureae; Rhizoma Fagopyri Dibotryis; Fructus actinidiae chinensis; Foliumet Ramulus Evodiae; HERBA VERONICAE DILATATAE; Stenoloma chusana; the Herb Polygoni Chinensis; Herba Boenninghauseniae; Elephantopus scaber L.; India skullcap; Herba Blumeae Lacerae; Arisaema balansae Engl. grass; Calyx Seu Fructus Physalis; Herba Rostellulariae; Radix Helicteris; Herba Thesii; Radix Ardisiae Crenatae; Antenoron filiforme herb; Radix Aristolochiae Kaempferi; Herba Polygoni cymosi; Flos Ilicis Asprellae; Ramulus Et Folium Picrasmae; the Canis famililiaris L. grass; Lignum et Radix Naucleae; LINGDANCAO difficult to understand; Bulbus Allii; Nidus Vespae; Venenum Bufonis; horse is got rid of bulky; Herba Botrychii; watermelon crystal; Cornu rhinocerotis; Cornu Bubali; Radix Rehmanniae; Rhizoma Osmundae Japonicae; Rhizoma Dryopteris Crassirhizomatis; catechu, Cortex Ilicis Rotundae; Folium Hibisci Mutabilis; Cornu Saigae Tataricae; Carapax Eretmochelydis; Margarita; Concha Margaritifera; Concha Haliotidis; Rhizoma Gastrodiae; Ramulus Uncariae Cum Uncis; Concha Erosariae seu Cypraeae; Scorpio; the joy centipede; Bombyx Batryticatus; Pheretima; Folium Apocyni Veneti; Fructus Tribuli; Haematitum

Remarks 2, Semen Armeniacae Amarum, Fructus Perillae, Radix Asteris, light branch collude, Flos Farfarae, Pi be leaf, Herba Chelidonii, Cortex Mori, the Radix Stemonae, Semen Ginkgo, Folium Ginkgo, Radix Platycodonis, Flos Daturae, Flos Gomphrenae, Herba Ardisiae Japonicae, Herba Polygalae Japonicae, full leaf Cephalanthera falcata (Thunb) Lindl, aster, Folium Viticis Negundo, the Strobilus Pini, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Herba Eupatorii Lindleyani, Floium Rhododendri Simsii, sabia, Bulbus Fritillariae Pallidiflorae, Radix Physochlainae, Cortex Syringae, Folium Alstoniae Scholaris, Herba Gnaphalii Affinis, Oleum Folium Artemisiae Argyi, Herba Cymbopogonis, Rhizoma Seu Herba Bergeniae

Pericarpium Citri Reticulatae, dried tangerine peel, Pericarpium Citri Reticulatae Viride, Vascular aurantii, Fructus Aurantii, Fructus Aurantii Immaturus, Fructus Citri Sarcodactylis, Lignum Dalbergiae Odoriferae, Lignum Aquilariae Resinatum, Radix Vladimiriae, the Radix Aucklandiae, Lignum Santali Albi, Rhizoma Cyperi, the Radix Linderae, Bulbus Allii Macrostemonis

Moschus, Borneolum Syntheticum, Rhizoma Acori Graminei, Rhizoma Anemones Altaicae, Rhizoma Acori Calami, Styrax, Benzoinum, Ambra Grisea, JIANANXIANG, Herba thymi vulgaris, Flos Carthami, Stigma Croci, Herba Leonuri, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Corydalis, Radix Curcumae, Semen Persicae, Radix Oenotherae erythrosepalae, Rhizoma Curcumae Longae, Olibanum, Myrrha, Lignum Sappan, Hirudo, Eupolyphaga Seu Steleophaga, the speckle insect destructive of the roots of seedlings, busy worm, Squama Manis, Radix Paeoniae Rubra, Flos Rosae Chinensis, Radix Ilicis Pubescentis, Oletum Trogopterori, Ramulus Euonymi.

Claims (10)

1, the compositions of a kind of per os, nasal administration, Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent, it is characterized in that: it is to be formed by natural milk, natural aromatic spice, pharmacological active substance and Foradil Aerolizer formoterol fumarate with fragrant treatment effect, spray, spray auxiliary agent additive combination, and natural milk accounts for 0.1～99.999% of total composition; 0.001ppm～5% with natural aromatic perfumes comprise total composition of fragrant treatment effect.

2, the natural milk in the compositions of per os as claimed in claim 1, nasal administration, Foradil Aerolizer formoterol fumarate, spray, the spray auxiliary agent, it is characterized in that: natural milk comprises: mammiferous milk, plant milk, wherein mammal is meant all mammals, but based on milk that cattle, sheep, horse were produced; Plant milk is meant safe, nontoxic, can be made into the seeds of leguminous plant of natural Emulsion, made bean milk, the nut milk of kernel of edible nut-seed through processing.

3, per os as claimed in claim 1, the compositions of nasal administration, Foradil Aerolizer formoterol fumarate, spray, natural aromatic spice in the spray auxiliary agent with fragrant treatment effect, it is characterized in that: the optional usefulness of natural aromatic spice with fragrant treatment effect has the plant essence oil of fragrant treatment effect and those can be used as medicine, food, the spice of cosmetics and highclass perfumes, correctives reaches to rectify smells the nontoxic of agent, single with or be used in combination that the people is produced is a kind of pure and fresh, happy, quiet, comfortable, the natural perfume material of relaxed and joyful sensation and the crude extract of natural perfume material, extract and the synthetic compound of deriving out by extract, the plant essence oil that wherein has fragrant treatment effect, the crude extract of natural perfume material and natural perfume material is including, but not limited to (hardship) Folium citri sinensis (Petitgrain bigarade and Paraguay) oil, Algeria Oleum Pelargonii Graveolentis Oilof Geranium Algerian, Herba Ardisiae Japonicae (Ardisia Leaf) oil, Tansy oil. Oil of Tansy, Folium Artemisiae Argyi (Artemisia argyi) oil, Benzoinum (Benzoin) oil, eucalyptus oil Oil of Eucalyptus, Australia Oleum Santali albi Oil of SandaIwood Australian, Fructus Anisi Stellati (Aniseed star) and Fructus Foeniculi (Anise) oil, Brazilian sassafras oil oil of Brazilian Sassafras, Brazilian rosewood oil Oil of Bois de Rose Brazilian, Oil of sweet flag Oil ofCalamus, cajeput oil oil of Cajeput, Pseudobulbus Bletillae (Rhizoma Bletillae) oil, Flos micheliae Albae oil Oil of Michelia Alba, Flower, Michelia leap oil Oil of Michelia Alba, Leaf, Radix Paeoniae Alba oil, Rhizoma Atractylodis Macrocephalae oil, common perilla oil, Radix Cynanchi Atrati oil, Radix Angelicae Dahuricae oil, thyme oil Oil of Thyme, the Oil of Cedar leaf of oil of cedar leaf, Cupressus funebris Endl. (Cedarwood) oil, oriental arborvitae seed oil, Rhizoma Pinelliae oil, Cortex Syringae oil, Radix Glehniae oil, Cubeb oil Oil ofCubeb, bouchi oil, oil of Semen Alpiniae Katsumadai, Fructus Tsaoko oil, tea tree oil Oil of Tea Tree, Rhizoma Atractylodis (Atractyllis) oil, Oleum Bupleuri, linaloe oil, Oleum Citri Reticulatae, Radix Paeoniae Rubra oil, Radix Vladimiriae oil, Rhizoma Chuanxiong oil, chamomile oil (Britain's type) Oil of Chamomile English Type, thorn bat oil Oil of Juniper Berries, the sage oil Oil of Sage Dalmatian Type of Dalmatia, Oleum Bulbus Allii Oilof Garlic, atlas cedarwood oil Oil of Cedarwood Atlas, turtle turtle leaf (Petitgrain Dai-dai) oil, Angelica root oil oil of Angelica Root, Angelica seed oil oil of Angelica Seed, Texas cedar wood oil oil ofCedarwood Texas, Virginia Cedar oil Oil of Cedarwood Virginia, seed oil of Herba Apii graveolentis Oil ofCelery Seed, Flos Caryophylli oil Oil of Clove Bud, clove-stems oil oil of Clove Stem, the Oil of Clove Leaf of Folium Caryophylli oil, green cognac Oil of Cognac Green, Ocimum Basilicum (Basil oil eugenoItype) oil, Oleum Caryophylli resin Oleoresin of Cloves, East Indian sandalwood oil Oil of sandalwood EastLndian, Ilicis Purpureae (Wintergreen) and Gaultheria forrestii (Gaultheria) oil, cardamom oil, doubleteeth pubescent angelica oil, oil of Herba Asari Forbesii, the Folium Rhododendri Simsii leaf oil, gin (Juniperberry) oil, Oleum Curcumae, Herba Centipedae oil, Lignum cinnamomi camphorae (Ho, 8hiu) oil, linalool (single from) Linalool (lsolated), verbena (Verbena) oil, opopanax oil Oil of Opopanax, hyacinth (Hyacinth) oil, the sweetgum fatty oil, Fructus Citri Sarcodactylis (Bergamot) oil, Linaloe oil Oil of Linaloe wood, JIANANXIANG oil, marjoram oil Oil of Marjoram Sweet, Radix Et Rhizoma Nardostachyos (Spikenard) oil, Rhizoma Alpiniae Officinarum oil, Rhizoma Ligustici oil, galbanum oil oil of Galbanum, Pueraria lobota thread (Caraway) seed oil, Cuba oil Oil of Copaiba, Flos Eriocauli oil, patchouli oil Oil of Patchouli, costus root oil Oil of Costus Root, Flos Osmanthi Fragrantis (Osmanthus) oil, castoreum (Castoreum), bashfully spend (silvery white Acacia farnesiana Willd.) (Mimosa) oil, Fructus piperis nigrum oil Oil of Black Pepper, black pepper oleoresin Oleoresin of Black Pepper, tonka beans (Tonka Bean) oil, Fructus Galangae oil, Cortex Magnoliae Officinalis oil, penner oil Oil of Pennyroyal, carrot-seed oil Oil of Carrot Seed, Herba Coriandri oil, amber oil, Radix seu folium abelmoschi moschati seed oil Oil of Ambrette Seed Liquid, acute seed oil, Fructus Tribuli oil, Canada Semen Abietis Delavayi oil oil of Fir NeedleCanadian, oleum abietis Oil of Fir Needle Siberian, Canadian snake root oil Oil of SnakerootCanadian, Rhizoma Zingiberis Recens pool resin Oleoresin of Ginger, Rhizoma Curcumae Longae oil resin Oleoresin of Tumeric, oil of ginger oil of Ginger, Rhizoma Zingiberis Recens grass (Gingergrass) oil, Lignum Dalbergiae Odoriferae oil, mentha piperita oil Oil of Mentha Piperita, Acacia farnesiana Willd. (Cassie) oil, lonicera oil, Herba Schizonepetae oil, rectification Eucalyptus globulus Labill leaf oil (Portugal) oil of EucatyptusGlobulus Labilllardiere Rectifled (Portugal), rectified oil of turpentine Oil of Turpentlne Rectified, Rhizoma Anemones Altaicae oil, oil of Folium Et Cacumen Murrayae, oil of Flos Chrysanthemi, tangerine oil, cananga oil oil of Cananga, cymin oil Oil ofCumin, Common Wormwood oil Oil of Wormwood, bigarabe flower (Neroli bigarade) and Citrus aurantium L. var. amara Engl. Oil, bitter orange oil Oilof Orange Bitter, Herba Corydalis Bungeanae oil, Semen Armeniacae Amarum oil oil of Bitter Almond FFPA, coltsfoot (Tussilaga) caul-fat, capsicum oleoresin Oleoresin of Capsicum, Herba Bidentis Tripartitae oil, cold grinding lemon rubber oil oil of Lemon ColdGrinded, oleum Citri sinensis Oil of Orange Sweet Cold Pressed colds pressing, oleum bergamottae (Italy) Oilof Bergamot Expressed (ltaly) colds pressing, bergamot approaches He (Bergamot Mint) oil, rectification birch tar oil Oil of BirchTar Rectifled, cold pressed lime oil Oil of Lime Cold Pressed, Fructus Forsythiae oil, Zibethum (Civet), Oleum Menthae Rotundifoliae Oil of Spearmint, Oleum Menthae Rotundifoliae (rectification) Oil of Spearmint Rectifled, stay Buddhist nun Wang Oleum Pelargonii Graveolentis Oil of Geranium Eeunion, dragon punt-pole oil oil of Estragon, Ambra Grisea (Ambergris or Ambra), basil oil (staying Buddhist nun Wang) Oil of Basil (Reunion), Herba Verbenae oil, Semen Capparis oil, horse Guerlain (Marjoram) oil, Herba Kalimeridis grass oil, Herba Verbenae (Vervain) oil, the wild pepper seed oil, Herba euphorbiae lunulatae oil, Myrrha Oil of Myrrh, Flos Rosae Rugosae (Rose) caul-fat, palmarosa oil Oil of Palmarosa, rose wood (Rosewood or Bois de Rose) oil, U.S. Chenopodium Oil Oil of Wormseed American, oil of rosemary Oil of Rosemary, Peru rosewood oil Oilof Bois de Rose Peruvian, Peru balsam oil Oil of Balsam Peru, Morocco Oleum Pelargonii Graveolentis Oil ofGeranium Moroccan, jasmine (Jasmin) oil, Herba Ecliptae oil, the Paeonia suffruticosa haze wax, Oleum Viticis Negundo, wooden slippers showy flowers of herbaceous plants (Reseda or Mignonette) oil, nanmu leaf (Machilus leaf) oil, eucalyptus citriodora oil Oil of EucalyptusCitriodora, Indian oil of verbena 0H of Lemongrass, the oily Oil of Parsley Herb of parsley grass, the oily Oil of of parsley fruit (really) Parsley Seed, square-bottomed bamboo basket seed oil oil of Dill seed European is transplanted in Europe, oleum pini sylvestris Oil ofPinus Sylvestris, Herba Eupatorii Fortunei oil, hop oil Oil of Hops, Pollen Typhae oil, Rhizoma Homalomenae oil, peucedanum oil, incised notopterygium oil, oleoresin parsley Oleoresin of Celery, Herba Artemisiae Annuae oil, bluish yellow Elecampane oil (German type) Oil of ChamomileGerman Type, Pericarpium Citri Reticulatae Viride oil, ginseng oil, Semen Myristicae (Nutmeg) and Arillus Myristicae (Mace) oil, Arillus Myristicae oil Oil of Mace, Arillus Myristicae oleoresin Oleoresin of Mace, cinnamon leaf oil oil of Cinnamon leaf, Sri Lanka Cortex Cinnamomi leaf oil Oil of Cinnamon leaf Ceylon, Oleum Cinnamomi (China) oil of Cassia, China, Oleum Cinnamomi, Olibanum oil Oil of Olibanum, Seychelles Cortex Cinnamomi leaf oil oil of Cinnamon Leaf Seychelles, rhizoma sparganic oil, the Cortex Mori haze wax, Fructus Amomi oil, litsea cubeba oil Oil of Litsea Cubeba, Rhizoma Kaempferiae oil, Fructus Cnidii oil, Moschus (Musk).Oleum thymi vulgaris, Rhizoma Acori Graminei oil, Herba Gnaphalii Affinis (Gnaphalium) oil, oil of aglaia odorate Oil of Aglaiaodorata, Flower, Rhizoma Acori Calami oil, Herba Stachydis Japonicae oil, Herba Kyllingae oil, Flos Narcissi chinensis (Narcissus) and yellow fluid Shan flower (Jonquil) oil, Ceylon cinnamon bark oil oil of Cinnamon Bark Ceylon, Folium Pini (Pineneedle and Firneedle) oil, Storax oil Oil of Styrax, Lignum Sappan oil Tai Bay Red Juniper (Cypress Taiwan) oil, Lignum Santali Albi (Sandalwood) oil, Fructus Rhodomyrti Folium Lauri nobilis (Bay or Bay Leaf) oil, superfine Cananga odorata oil Oil of Ylang YlangExtra, natural Herba Menthae internal organs Menthol (Natural), paprike oleoresin Oleoresin of Paprika, sweet basil (Sweet basil) oil, Tolu balsam oil Oil of Tolu Balsam, Polianthes tuberosa L. (Tuberose) oil, Radix Clematidis oil, Fructus Gardeniae (Gardenta) caul-fat, lindera oil, the slender acanthopanax haze wax, Fructus Schisandrae oil, Spain Herba Origani oil Oil of Origanum, Spanish, Oil of Spanish sage Oil of Sage Spanish, Radix Panacis Quinquefolii oil, Oleum Asari, Spica Prunellae oil, Herba Agrimoniae oil, Herba Melissae officinalis (Melissa) oil, savory oil (summer variety) Oil of Savory (Summer Variety), Rhizoma Cyperi (Cyperus) oil, vetiver oil Oil of Vetiver, vanilla (Vanilla) Oleum Glycines, cascarilla Oil ofCascarilla, Herba Cymbopogonis Citrari (Citronella) oil, Andropogon nardus oil Oil of Citronella Ceylon, Herba Moslae oil, carnation (Carnation) oil, myrtus communis (Myrtle) oil, oil of geranium, Oleum Pelargonii Graveolentis Oil of Geranium, citron oil, Salvia Sclare L.oil Oil of Clary Sage, oak moss and tree moss (Oak Moss and Tree Moss) balsam and absolute oil, Cardamom oil oil of Cardamon, Fructus Foeniculi (Fennel) oil, oil of Rhizoma et radix valerianae Oil of Valerian, Flos Magnoliae oil, almond oil, Radix Dipsaci oil, Radix Scrophulariae oil, Oleum lavandula angustifolia Oil of Lavender, aspic oil Oil of lavenderSpike, squeezing tangerine oil Oil of Tangerine expressed, Arizona Fructus Citri Limoniae oil (cold pressing), Oil of LemonArizona Cold Pressed, asia peppermint vegetable oil Oil of Mentha Arvensis Partially Dementholized, coriander (Coriander) seed oil Yan Lan grass (Vettver) oil, labdanum oil oil of Labdanum, ocean GANJU (Camomiles), oil of Bulbus Allii Cepae Oil of Onion, Flos Matricariae chamomillae (Chamomile) oil, the Herba Dendranthematis indici caul-fat, Herba Eupatorii Lindleyani (Eupatorium) oil, Herba Solidaginis oil, fragrant cananga one Ka Nanjia (Ylang-Cananga) oil, oil of ylang ylang complete Oilof Ylang Ylang Complete, ylang ylang oil Oil of Ylang Ylang, Fructus Alpiniae Oxyphyllae oil, the Italy's Citrus chachiensis Hort. oil Oilof Mandarin ltaly big sharp permanent flower of Righteousness (Immortelle) oil, oil of Herba Artemisiae Scopariae, Herba Epimedii oil, silver fir oil Oilof Abies Alba, India dill seed oil oil of Dill Seed lndian, U.S. dill oil oil of DillweedAmerican, eucalyptus globolus (Eucalypus) oil, Stigma Maydis oil, Radix Curcumae oil, guaiac wood oil Oil ofGuaiacwood, orrisroot oil Oil of Orris Root, lovage oil Oil of Lovage, Oleum Citri grandis (squeezing) Oil of Grapefruit Expressed, laurel Oil of Bay Leaf laurel Oil of Laurel Leaf, Radix Oenotherae erythrosepalae oil, hemlock oil Oil of Spruce, Herba Cymbopogonis oil Oil of Rue, lavandin oil Oil ofLavandin, lavandin oil (France) Oil of Lavandin Abrialis (France), eupatoria oil, Oleum Camphora Oil ofCamphor 1070, white camphor oil Oil of Camphor White 860-880, distilled lime oil Oil of LimeDistilled, distillation Fructus Citri Limoniae oil Oil of Lemon Distilled, distillation oleum Citri sinensis Oil of Orange Distilled, fat wingceltis oil Oil of Amyris, Aranea Oleum sesami, Fructus Aurantii oil, Fructus Aurantii Immaturus oil, China Guizhou Cedar oil Oil of CedarwoodGuizhou, China, middle Country Yu Lan caul-fat, pimento leaf oil Oil of Pimenta Leaf, Java citronella oil Oil ofCitronella Java Type, purple (in vain) Flos Caryophylli (Lilac) oil, violet leaf (Violet leaf) oil, Radix Asteris (Aster Root) oil; Wherein have fragrant treatment effect natural aromatic spice extract and by the synthetic compound that extract derives out comprise but not be limited to: (no chlorine) benzyl acetate; " nerone "; " fenxizisu "; " myrac aldehyde "; " the blue or green aldehyde of olive "; " lilestralis "; " jasmonyl "; " ligustral "; " bergamot aldehyde "; " LYRAL "; " strawberry aldehyde "; 1; the 8-cineole; 2; 6-dimethyl heptene-5-aldehyde-1; 2; 7; 8-front three basic ring 12 triolefins-2; 5; the 9-methyl ketone; 2-ethyl hexanal ring second two acetals; 3; 3-Dimethylcyclohexyl methyl ketone; the 3-methylindole; 404 fixastive; 5-phenyl-5-methyl hexanone-3; the 6-methylquinoline; 6-methyl tetrahydroquinoline; N-methyl methyl 2-aminobenzoate; thymol; cedar wood alcohol; cedrenol; benzenpropanal; benzaldehyde; benzoic acid; benzoic acid-3-methyl butene-2-ester; benzyl benzoate; cinnamyl benzoate; essence of Niobe; ethyl benzoate; isobutyl benzoate; the positive butyl ester of benzoic acid; phenyl acetaldehyde dimethyl acetal; hyacinthin; phenylacetic acid; phenylethyl phenylacetate; p-cresyl phenylacetate; santalyl phenylacetate; geranyl phenyl acetate; ethyl phenylacetate; isobutyl phenylacetate; the positive butyl ester of phenylacetic acid; 1-Phenylethanone.; phenethyl ester; benzylalcohol; phenylethyl propionate; benzyl propionate; rhodinyl propionate; geranyl propionate; ethyl propionate; isoamyl propionate; third phenylpropanol; third in oneself; third nonalactone; third undecalactone; third caprylolactone; Mentholum; menthone; nerol; nerolidol; anisyl alcohol; anisic aldehyde; diacetyl; benzyl butyrate; butyl butyrate; amyl butyrate and isoamyl butyrate; geranyl butyrate; ethyl n-butyrate.; eugenol; eugenol methyl ether; methyl para-cresol; melilotal; acetanisole; para hydroxybenzene ethyl-methyl ketone; to ethyl-first position; first position-dimethyl benzene propionic aldehyde; benzophenone; diphenyl-methane; diphenyl ether; musk xylene; dimethyl benzyl carbinol; dimethyl is for hydroquinone; dihydro jasmone; MDJ; dihydromyrcenol; trans-anethole; linalool; phantolid; Eucarvone; heptyne hydroxy acid methyl ester; cognac oil; cinnamic alcohol; methyl decine-carbonate; cinnamic acid; phenyl ethyl cinnamate; benzyl cinnamate; cinnamyl cinnamate; the cinnamic acid methyl ester; ethyl cinnamate; isobutyl cinnamate; pentadacanolide; cyclopentadecanone; safrole; allyl hexanoate; ethyl hexanoate; methyl Cupressus funebris Endl. base ether; methyl nonyl acetaldehyde; methyl octyl acetaldehyde; methyl second position naphthyl ketone; methyl n-hexyl ketone; the methyl n-nonyl ketone; methyl-n-amyl ketone; methyl ionone; cedryl formate; phenyl ethyl formate; benzyl formate; linalyl formate; rhodinyl formate; citronellyl formate; geranyl formate; Ethyl formate; isoamyl formate and amyl formate; the formic acid n-octyl; the first position; first position one dimethyl phenylethyl carbinol; first position cedroxyde; first position amyl group is hung alcohol; alpha-amyl cinnamic aldehyde; first position hexyl is hung aldehyde; rosalin; farnesol; musk ambrette; linalyl anthranilate; ortho-aminobenzoic acid first position Oleum Pini ester; methyl 2-aminobenzoate; cibetone; Borneolum Syntheticum; Ambergris ether; maltol; rhodinol; rose oxide; methyl jasmonate; interior undecylene aldehyde; limonene; lemonile; citral; citral diethyl acetal; pinene; hydroxycitronellal; the sandalidol; nonadiene-2; 6-aldehyde; the n-nonanoic acid phenethyl ester; ethyl pelargonate; cinnamic aldehyde; celestolide; tricyclic isochroman musk; the trimethylbenzene Moschus; Moschus moschiferous certain herbaceous plants with big flowers lactone; Moschus 105; astrotone; the Moschus hydrocarbon; muscone; lauronitrile; Fructus anethi aldehyde; the salicylic acid phenethyl ester; the salicylic acid ethyl ester; benzyl salicylate; methyl salicylate; isoamyl salicylate; cis n-hexylene-3-alcohol; tetramethyl octahydro naphthyl ketone; tetramethyl acetyl group octahydro naphthalene; tetrahydrogeraniol; terpineol; santalol; musk ketone; cyclamen aldehyde; coumarin; carvacrol; vanillin; citronellol; 3,7-Dimethyl-6-octenenitrile; citronellal; geraniol; sclareol; Nitrobenzol; octyne hydroxy acid methyl ester; ethyl caprilate; bromostyrene; nitrous ether (ethyl nitrite); vetiverol; heliotropin; second changes the former ester of dimethyl benzene ethyl; second changes the former pound of dimethyl grandfather base; ethyl vanillin; acetic acid-2-tert-butyl group cyclohexyl; Cedryl acetate.; phenethyl acetate; cassie ketone; butyl acetate; narceol; linalyl acetate; cinnamyl acetate; borneol acetate; rhodinyl acetate; nopyl acetate; Tricyclodecenyl acetate; terpinenyl aceatae; methyl phenyl carbinyl acetate; santalyl acetate; citronellyl acetate; geranyl acetate; vetacetyl; acetic acid second position decahydronaphthalene ester; ethyl acetate; isoamyl acetate; myrcenyl acetate; acetic acid ester in the positive last of the ten Heavenly stems; n-nonyl acetate; the acetic acid n-octyl; second position phenethanol; neroline bromelia; second position naphthol ethyl ether; acetyl cedrene; acetyl iso-eugenol; ethyl acetoacetate; isopropyl indane Moschus; isolongitolanone; isoeugenol; the isoeugenol benzylic ether; the isoeugenol methyl ether; isocyclocitral; isosafrole; isojasmone acid methyl ester; phenylethyl isovalerate; ethyl isovalerate; iso-amyl iso-valeriate; indole; irone; myrcenol; n-butyric acie; n-butyric acie Flos Rosae Rugosae ester; positive dibutyl sulfide; n-heptanol; Decanol; n-capric aldehyde; hexanol; n-nonyl alcohol; n-nonyl aldehyde; n-dodecanol; positive lauric aldehyde; positive undecyl alcohol; n-undecylic aldehyde; positive hendecene-10-alcohol-1; positive hendecene-10-aldehyde-1; positive glutaconic nitrile and isovaleric acid geraniol ester; n-octyl alcohol; n-octaldehyde; ionoionone more preferably has the plant essence oil of fragrant treatment effect.

4, the compositions of per os as claimed in claim 1, nasal administration, Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent, it is characterized in that: pharmacological active substance, do not limit to Chinese medicine, Western medicine, water-soluble medicine, liposoluble medicine, insoluble medicine, as long as can work or can absorb the pharmacological component that works, can use by nasal mucosa, oral mucosa and respiratory tract in nasal mucosa, oral mucosa and respiratory tract part; Especially the high and oral medicine that can not absorb fully of the medicine that liver first-pass effect is big, water solublity, decompose significant medicine at digestive tract, and those need and can to see through the medicine etc. of blood brain barrier by nasal cavity more suitable; Its consumption is that usual amounts is not done particular determination.

5, the compositions of per os as claimed in claim 1, nasal administration, Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent, it is characterized in that: Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent additive, when not repelling the non-natural additive, select for use the natural milk with identical function, natural aromatic spice, phospholipid and derivant thereof to substitute with fragrant treatment effect as far as possible; Wherein, natural emulsified and the suspending effect that natural milk has, can substitute all non-natural surfactants, additive in the conventional formulation, it is auxiliary to add an amount of phospholipid and derivant thereof in the time of if necessary, water soluble drug, fat-soluble medicine, insoluble drug are made emulsion-type, mixed suspension form and even lipid build solution, this solution packing can be obtained emulsion-type, mixed suspension form and even lipid build oral cavity, nasal-cavity administration spray; This solution promptly be can be made into the Foradil Aerolizer formoterol fumarate that can be used for oral cavity, nasal-cavity administration or makes the spray auxiliary agent after lyophilization or cryogenic vacuum spray drying make the compositions microsphereization; Also has the enzyme effect of pressing down behind the natural milk nasal-cavity administration in the preparation of the present invention simultaneously, the effect of protection nasal mucosa, the PH cushioning effect, the osmotic pressure Accommodation is detained medicine and is prolonged the adhesive attraction of administration time and medicine is carried out emulsifying, solubilising, stable effect in nasal cavity, oral cavity; Wherein, natural aromatic spice is when finishing it and improving patients ' psychological state and fragrant treatment functions, their great majority also have the function of natural drug penetration enhancer, the Natural antioxidant, natural antiseptic agent and antibacterial, can substitute all non-natural surfactants, additive in the conventional formulation, can add an amount of phospholipid and derivant thereof in the time of if necessary and unite use with it with auxiliary its drug osmotic promotion function.

6, the compositions of per os as claimed in claim 1, nasal administration, Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent, it is characterized in that: compositions core component can be inserted this Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent with each component by following combination when preparation Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent:

(1) one or more natural milk

(2) one or more have the natural aromatic spice of fragrant treatment effect

(3) zero kind, one or more pharmacological active substancies,

Then the needs that constitute according to compositions add Foradil Aerolizer formoterol fumarate, spray, spray auxiliary agent additive:

(4) zero kind, one or more solvents, latent solvent matchmaker,

(5) zero kind, one or more solubilizing agents,

(6) zero kind, one or more emulsifying agents

(7) zero kind, one or more pharmaceutical penetration enhancers

(8) zero kind, one or more enzyme inhibitors,

(9) zero kind, one or more nasal mucosa protective agents,

(10) zero kind, one or more adhesive agents,

(11) zero kind, one or more slow releasing agents, controlled release agent,

(12) zero kind, one or more antiseptic,

(13) zero kind, one or more correctivess,

(14) zero kind, one or more antioxidants,

(15) zero kind, one or more stabilizing agents,

(16) zero kind, one or more carriers,

(17) zero kind, one or more diluent,

(18) zero kind, one or more lubricants,

7, a kind of per os, the preparation method of the carrier-free Foradil Aerolizer formoterol fumarate of nasal administration, it is characterized in that: it is by the described natural milk of claim 1～6, natural aromatic spice with fragrant treatment effect, pharmacological active substance, Foradil Aerolizer formoterol fumarate additive and proportioning thereof, pass through active particle, the preparation of additional particulates, mix, several procedures such as packing are finished, wherein the preparation method of active particle is: with natural milk, natural aromatic spice with fragrant treatment effect, pharmacological active substance and required Foradil Aerolizer formoterol fumarate additive pass through mix homogeneously, homogenizing, (or the lyophilization of cryogenic vacuum spray drying, pulverize) etc. operation be prepared from, it is characterized in that: when Foradil Aerolizer formoterol fumarate is pulmonary administration, the particle diameter of active particle should be controlled at below the 20 μ m, preferred 0.1～10 μ m, more preferably 0.5～7 μ m; When Foradil Aerolizer formoterol fumarate was nasal cavity, oral administration, the particle diameter of active particle should be controlled at below the 350 μ m, preferred 10～100 μ m, more preferably 30～50 μ m; If (the high molecular slow-release material can use separately or unite use with natural milk to have added the high molecular slow-release material in the liquid of active particle before spray drying, and the skeleton thing of formation active particle), this moment, the active particle of gained had slow release effect: the Foradil Aerolizer formoterol fumarate of gained gets final product quick-acting emergencies and also have slow-release function after general active particle and slow release active particle make up by a certain percentage, so become long-acting Foradil Aerolizer formoterol fumarate; The control of active particle particle diameter: by lyophilization, the prepared active particle of comminuting method, the size of its particle diameter is controlled by pulverizing process; By the prepared active particle of cryogenic vacuum spray drying method, the size of its particle diameter is by two procedures controls such as the concentration of adjusting the mixed liquor before the spray drying, atomisation pressures; Wherein additional particulates mainly is meant the micro powder granule of lubricant.

8, the preparation method that the carrier dry powder inhalant is arranged of a kind of per os, nasal administration, it is characterized in that: it is by the described natural milk of claim 1～6, the natural aromatic spice with fragrant treatment effect, pharmacological active substance, Foradil Aerolizer formoterol fumarate additive and proportioning thereof, preparation by active particle, carrier granular, additional particulates, mix, several procedures such as packing are finished, and wherein the preparation method of active particle is identical with claim 9 no longer repeatedly states; The particle diameter of carrier granular should be controlled at below the 1000 μ m, preferred 20～350 μ m, more preferably 70～100 μ m; Wherein additional particulates mainly is meant the micro powder granule of lubricant.

9, the spray preparing process of a kind of per os, nasal administration, it is characterized in that: it is by the described natural milk of claim 1～6, the natural aromatic spice with fragrant treatment effect, pharmacological active substance, spray additive and proportioning thereof, finish by several procedures such as batching, adjustment, homogenizing processing, sterilization, packing

10, the preparation method of the spray auxiliary agent of a kind of per os, nasal administration, it is characterized in that: it is by the described natural milk of claim 1～6, the natural aromatic spice with fragrant treatment effect, pharmacological active substance, spray auxiliary agent additive and proportioning thereof, by batching, adjustment, homogenizing handle, sterilization, dry, divide several procedures such as making auxiliary agent to finish; Wherein drying preferably adopts lyophilization, cryogenic vacuum spray drying; Wherein dividing the spray auxiliary agent of making can be the solid preparation that any dissolved easily and easy sealing is preserved.