CN112826839A

CN112826839A - Solid powder composition of plant traditional Chinese medicinal materials and preparation method thereof

Info

Publication number: CN112826839A
Application number: CN201911153438.2A
Authority: CN
Inventors: 王泽人; 徐俊; 陈顺; 徐勇
Original assignee: Shenzhen Pharmacin Co Ltd
Current assignee: Shenzhen Pharmacin Co Ltd
Priority date: 2019-11-22
Filing date: 2019-11-22
Publication date: 2021-05-25

Abstract

The invention relates to a solid powder composition of plant traditional Chinese medicinal materials and a preparation method thereof, and is characterized in that the solid powder composition can form stable suspension after being dissolved again by adding water, and the sedimentation volume ratio is not lower than 0.4 after standing for 3 hours. The solid powder composition prepared by the invention, which is composed of pseudo-ginseng and American ginseng, can obviously improve the stability of suspension and the absorption of nutrient components, and is beneficial to the stability of effective active components in the processes of packaging, storing and transporting. The solid powder composition can also be used as health food for relieving fatigue.

Description

Solid powder composition of plant traditional Chinese medicinal materials and preparation method thereof

Technical Field

The invention belongs to the field of traditional Chinese medicine processing and health-care food, and particularly relates to a solid powder composition of plant traditional Chinese medicines and a preparation method thereof, in particular to a solid powder composition of pseudo-ginseng and/or American ginseng and a preparation method thereof and health-care food.

Background

The traditional Chinese medicine is a national treasure, and the traditional Chinese medicine comprises animal-derived and plant-derived traditional Chinese medicines, wherein the plant-derived traditional Chinese medicines (also called plant traditional Chinese medicines) are numerous, and the known traditional Chinese medicines comprise pseudo-ginseng, American ginseng, Chinese angelica, isatis root, radix bupleuri, dried orange peel, andrographis paniculata, codonopsis pilosula, rhodiola rosea, coptis chinensis, turmeric, honeysuckle, mint, motherwort and the like.

Notoginseng radix and radix Panacis Quinquefolii are both from Panax of Araliaceae, and are used as raw materials. Notoginseng radix is root of Panax notoginseng (Burk) F.H.Chen of Araliaceae, has effects of removing blood stasis, stopping bleeding, and relieving swelling and pain, and can be used for hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury pain, and is the main ingredient of Yunnan white drug powder. Radix Panacis Quinquefolii is root of Panax quinquefolium L. of Araliaceae, has effects of nourishing yin, moistening lung, clearing heart fire, and tranquilizing mind, and can be used for treating yin deficiency, dry cough, cough with blood, dysphoria, insomnia, dreaminess, absentmindedness, etc. Because the two medicinal materials are derived from the same family and the same genus and are two plants with similar relativity, the chemical components are very similar, for example, the medicinal materials both contain ginsenoside components, and western pharmaceutical researchers generally classify the pseudo-ginseng and the American ginseng into the medicines with nourishing effect together according to the principle of the correlation between the chemical components and the pharmacological action.

The research reports of the pseudo-ginseng and the American ginseng participating in the formula for resisting fatigue are more, but most of the formula relates to a plurality of traditional Chinese medicines and has complex components. In addition, most of the existing reports are the combination of conventional decoction pieces, and the researches on extraction and biological utilization of active components are less. The quality of the pseudo-ginseng is hard and relatively hydrophobic, the extraction is difficult, and the waste of medicinal materials is often more. The active ingredients are the material basis of the efficacy and the action of the traditional Chinese medicinal materials, and how to more effectively extract the effective ingredients and the nutrient substances of the pseudo-ginseng and the American ginseng is the main problem at present.

The existing methods for extracting active ingredients comprise water decoction, organic extraction, supercritical extraction, resin purification and the like, and the methods use more extraction solvents, so that the extraction efficiency is not high, and the organic extraction solvents are not easy to extract and then are removed, so that more medicinal materials are wasted, and nutritional ingredients are lost.

The traditional Chinese medicinal materials are ground into powder, such as pseudo-ginseng powder and American ginseng powder, and can be directly drunk by adding water, but generally, the suspension has poor stability and precipitates are easy to generate due to too large particle size.

The superfine grinding technology is a relatively mature grinding technology in recent years, and can grind materials to micron-sized or even nano-sized sizes. The superfine grinding technology is introduced into the field of traditional Chinese medicinal materials, plant cells of the traditional Chinese medicinal materials can be smashed, the wall-broken rate of the traditional Chinese medicinal materials is more than 95%, and after the cells are subjected to wall breaking, effective components in the cells can be fully released, so that the utilization rate of the traditional Chinese medicinal materials is greatly improved, and an organic extraction solvent used by a conventional extraction method is not required.

However, the micronization technology is often operated by a dry method, and the components of plant cells are complex, and besides small molecular active ingredients in general sense, the plant cells also contain a large amount of nutritional ingredients such as protein and polysaccharide, and the ingredients are often difficult to be effectively released by the dry method pulverization. Although various traditional Chinese medicinal materials are commercialized at present and are generally sold in the form of ultrafine powder, the traditional Chinese medicinal materials actually do not meet the corresponding requirements, and no corresponding combined ultrafine powder decoction pieces of panax notoginseng and panax quinquefolium are provided. In addition, the cell sap is fully released after the wall breaking and crushing, and nutritional ingredients such as protein, polysaccharide and the like are easy to deteriorate and contaminate bacteria, so that the long-term storage is difficult to realize. Therefore, more efficient special techniques are required.

In addition, although the particle size of the commonly advertised ultrafine powder on the market is mostly up to the micron level, in practice, after the ultrafine powder is stirred and dissolved by adding water, the suspension is very unstable and is very easy to precipitate, and the aim of convenient taking cannot be met.

Disclosure of Invention

The invention unexpectedly discovers that after the plant traditional Chinese medicinal materials are subjected to common crushing and airflow crushing, the plant traditional Chinese medicinal materials such as pseudo-ginseng and/or American ginseng can be subjected to superfine crushing to grind the plant traditional Chinese medicinal materials into powder D₉₀And drying below 30 μm to obtain solid powder with vegetable protein content higher than that of available superfine powder.

According to the invention, the suspension of the solid powder composition has a pronounced UV absorption at 280nm in the filtered aqueous solution after removal of the insolubles. After the 1% solid content panax notoginseng freeze-dried powder is filtered, the protein content in the aqueous solution is determined by BCA and is higher than 0.4mg/mL, preferably higher than 0.5mg/mL, and more preferably higher than 0.6 mg/mL. Moreover, compared with the panax notoginseng and American ginseng powder with the particle size range of the commercial fine powder or ultrafine powder, the protein content of the panax notoginseng and American ginseng solid powder composition is obviously increased through further ultrafine grinding and freeze-drying treatment.

The inventors have surprisingly found that a very stable suspension can be formed after reconstitution of the solid powder composition obtained by the above procedure with water. After different plant traditional Chinese medicinal materials are treated, the sedimentation volume ratio of the freeze-dried powder is obviously improved compared with that of corresponding fine powder, and the sedimentation volume ratio is preferably more than 2 times. Compared with the pseudo-ginseng superfine powder on the market, the stability of the suspension is also obviously enhanced.

In a mouse load test, the lyophilized powder and the fine powder are respectively fed to the mouse, so that the load bearing capacity of the mouse of the lyophilized powder group is obviously enhanced, and the mouse has a better anti-fatigue effect.

The invention relates to a solid powder composition of plant traditional Chinese medicinal materials, which is dissolved in water to form stable suspension, and the sedimentation volume ratio of the suspension after standing for 3 hours is not less than 0.4, preferably not less than 0.45, even not less than 0.8.

According to the invention, the water content of the solid powder composition is <5 wt.%, preferably <3 wt.%.

According to the invention, the solid powder composition may be notoginseng and/or american ginseng.

According to the invention, the solid powder composition can be a combination of pseudo-ginseng and American ginseng, and the mass ratio of the pseudo-ginseng and the American ginseng is 0.5-2:1, preferably 1: 1.

According to the present invention, the solid powder composition is a freeze-dried solid powder.

Accordingly, the present invention relates to a process for the preparation of a solid powder composition of plant medicinal materials comprising the steps of:

(1) pulverizing appropriate amount of dried Chinese medicinal materials into particle diameter D by coarse powder process₉₀<A coarse powder with the particle size of 450 mu m,

(2) pulverizing the coarse powder into particle size D₉₀Fine powder with the particle size of less than or equal to 100 mu m,

(3) pulverizing the above fine powder by ultramicro process to particle diameter D₁₀≤5μm，D₅₀≤15μm，D₉₀A powder suspension with the particle size less than or equal to 30 mu m,

(4) drying the superfine powder suspension.

The particle size of the invention is the result of dry measurement by adopting a Malvern laser particle sizer MS 3000.

According to the invention, any common pulverizer can be adopted in the coarse powder process without special requirements as long as the traditional Chinese medicinal materials can be pulverized into the particle size D₉₀<Coarse powder of 450 μm; the fine powder process preferably adopts a jet mill.

According to the invention, the ultramicro process is to further pulverize the plant traditional Chinese medicine fine powder by wet grinding in a proper solvent. A suitable vehicle is water. In the presence of surfactant, the surface tension of the medicinal powder can be reduced, and aggregation of the powder can be prevented. The solvent is preferably pure water. Milling includes, but is not limited to, sand mills, high pressure homogenizers, and the like.

According to the invention, the drying process of the powder suspension includes spray drying and freeze drying, etc., preferably freeze drying.

According to the present invention, a preferred preparation method comprises:

(1) accurately weighing the medicinal materials of the pseudo-ginseng and the American ginseng,

(2) pulverizing the medicinal materials in a common pulverizer to D₉₀<A coarse powder with the particle size of 450 mu m,

(3) placing coarse powder of Notoginseng radix and radix Panacis Quinquefolii in jet mill, pulverizing to particle diameter D₉₀Fine powder with the particle size of less than or equal to 100 mu m,

(4) adding water with the mass volume of 5-20 times of the fine powder of the pseudo-ginseng and the American ginseng, uniformly mixing, placing in a sand mill, and further carrying out superfine grinding until the particle size of the powder is D₁₀≤5μm，D₅₀≤15μm，D₉₀≤30μm。

(5) The powder suspension was collected and dried on a lyophilizer.

The invention also relates to a health food for relieving physical fatigue, which comprises a solid powder composition of pseudo-ginseng and American ginseng.

The solid powder composition prepared by the invention can obviously improve the stability of the suspension; the intracellular protein is fully released by superfine grinding and wall breaking treatment, which is more beneficial to the absorption of the nutrient (active) components of the pseudo-ginseng and/or the American ginseng; the active ingredients are more stable in the processes of packaging, storing and transporting through freeze drying. The powder solid composition consisting of the pseudo-ginseng and the American ginseng has better functions as an anti-fatigue health food.

Brief Description of Drawings

In order to more clearly describe the technical solution of the present invention, the following brief description is provided with reference to the accompanying drawings. It should be apparent that these drawings depict only some specific embodiments of the invention herein. The present invention includes, but is not limited to, these figures.

FIG. 1 is a particle size diagram of coarse powder, fine powder and lyophilized powder of Panax notoginseng and Panax quinquefolium of the present invention;

FIG. 2 is an electron microscope image of coarse powder, fine powder and lyophilized powder of Panax notoginseng and Panax quinquefolium of the present invention, wherein FIG. 2A is a scanning electron microscope image of the coarse powder, FIG. 2B is a scanning electron microscope image of the fine powder, and FIG. 2C is a scanning electron microscope image of the lyophilized powder;

FIG. 3 shows ginsenoside Rg in the coarse powder, fine powder and freeze-dried powder of Panax notoginseng and Panax quinquefolium of the present invention₁Ginsenoside Rb₁Ginsenoside Re and notoginsenoside R₁The graph of content measurement of (2).

Examples

For a further understanding of the present invention, preferred embodiments of the present invention will be described below with reference to examples. These descriptions are merely illustrative of the features and advantages of the solid compositions of the present invention and do not limit the scope of the invention.

Example one

Accurately weighing Notoginseng radix with certain mass, primarily pulverizing with high-speed multifunctional pulverizer to obtain particle diameter D₉₀<450 μm coarse powder, which was subsequently placed in a jet mill with the parameters set: the crushing pressure is 0.6-0.8 MPa, and the feeding pressure is 0.3-0.4 MPa, vibrating the powder by 80-100, and crushing the powder into fine powder with the particle size D90 being less than or equal to 100 mu m. Collecting the fine powder, adding water with the mass volume of 10-20 times, uniformly mixing, placing into a sand Mill (Wal WaBDyno-Mill Research Lab, Switzerland), grinding for 1 or more times for 60min each time, and further crushing the powder until the particle size of the powder is D10 being less than or equal to 5 mu m, D50 being less than or equal to 15 mu m and D90 being less than or equal to 30 mu m. The particle size is measured by a Malvern laser particle size analyzer MS 3000.

The powder suspension was collected and dried on a lyophilizer. Setting freeze drying parameters as, pre-freezing to-40 ℃ until the water suspension is completely crystallized, then reducing the vacuum degree to 0.133mbar, then increasing the temperature of the box body of the freeze dryer to 0 ℃ and keeping the temperature until the front box vacuum 1 and the front box vacuum 2 coincide, continuing drying for 2 hours, and further increasing the temperature of the box body to 25 ℃ and drying for 4 hours. The moisture content of the cold dry powder was determined to be <5 wt%.

Example two

Accurately weighing Notoginseng radix and radix Panacis Quinquefolii at a mass ratio of 1:1, and primarily pulverizing with high-speed multifunctional pulverizer to obtain particle diameter D₉₀<450 μm coarse powder, which was subsequently placed in a jet mill with the parameters set: the first crushing pressure is 0.6-0.8 MPa, the second crushing pressure is 0.6-0.8 MPa, the feeding pressure is 0.3-0.4 MPa, the vibration voltage is 80-100, and the materials are crushed into fine powder with the particle size D90 being less than or equal to 100 mu m. Collecting the fine powder, adding water with the mass volume of 10-20 times, uniformly mixing, grinding for 1 time for 60min each time in a sand Mill (WaBDyno-Mill Research Lab, Switzerland), and further crushing the powder until the particle size of the powder is D10 being less than or equal to 5 microns, D50 being less than or equal to 15 microns, and D90 being less than or equal to 30 microns. The particle size is measured by a Malvern laser particle size analyzer MS 3000.

The powder suspension was collected and dried on a lyophilizer. Setting freeze drying parameters as, pre-freezing to-40 ℃ until the water suspension is completely crystallized, then reducing the vacuum degree to 0.133mbar, increasing the box body temperature of the freeze dryer to 0 ℃ until the front box vacuum 1 and the front box vacuum 2 coincide, continuing drying for 2 hours, and further increasing the box body temperature to 25 ℃ for drying for 4 hours. The moisture content of the cold dry powder was determined to be <5 wt%.

EXAMPLE III

Example one prepared meal, powder and lyophilized powder were tested for particle size using a laser particle sizer and scanning electron microscopy. The laser particle size analyzer was a Markov Mastersizer 3000, and the scanning electron microscope was a JSM-5910LV model, Japan Electron Ltd (JEOL). The results are shown in FIGS. 1 and 2.

The particle size comparison with commercially available fine powder of notoginseng was carried out, and the results are shown in the following table 1:

TABLE 1 results of particle size measurement

The result shows that the particle size of the pseudo-ginseng reaches D90<15 mu m through the fine powder process, the freeze-dried powder is agglomerated to cause the measured particle size to be higher, but the particle size of the freeze-dried powder is smaller than that of the fine powder from the result of a scanning electron microscope, which shows that the medicinal material is further crushed after being ground by a sand mill through a wet method.

Example four

Example two Total saponins content determination of the prepared coarse powder, fine powder and lyophilized powder. According to the content determination method under the item of pseudo-ginseng in the first part of Chinese pharmacopoeia 2015 edition, the ginsenoside Rg is determined by high performance liquid chromatography₁Ginsenoside Rb₁Ginsenoside Re and notoginsenoside R₁。

The results show that (see figure 3), after micronization, the ginsenoside Rg in the panax notoginseng and American ginseng powder₁Slightly increased, but not greatly affected by further freeze-drying treatment, ginsenoside Rb₁Slightly reduced after further freeze-drying treatment, and slightly improved ginsenoside Re, and notoginsenoside R₁There is no significant difference. In general, the micronization process has no obvious influence on the legal active ingredients of the panax notoginseng and the panax quinquefolius, and the loss of the active ingredients is avoided.

EXAMPLE five

Protein contents of the pseudo-ginseng coarse powder, the pseudo-ginseng fine powder and the pseudo-ginseng freeze-dried powder prepared in the first example are detected, and meanwhile, the commercial ultra-fine powder is compared. And (3) respectively preparing suspensions with the solid content of 1% of different samples by adopting a BCA method, magnetically stirring for 30min, centrifuging (7000r/5min, filtering) to obtain supernate, preparing BSA (BSA) reference substance solution (4 points build a standard curve), and carrying out ultraviolet measurement (single wavelength 562, 5mm cuvette). See table 2 below for results:

TABLE 2 BCA assay results for protein content

Sample name	Protein concentration (mg/mL)
		Pseudo-ginseng coarse powder	0.3174
Notoginseng radix fine powder	0.3287
		Notoginseng radix lyophilized powder	0.6149
Yunnan Huaxin pseudo-ginseng powder 1605009	0.3860
		Gynura procumbens powder F20160507	0.4068

The results show that the protein release of the pseudo-ginseng is not greatly different when the pseudo-ginseng is treated by coarse powder and fine powder, and the protein release of the pseudo-ginseng fine powder is obviously improved after the pseudo-ginseng is further subjected to wet grinding and freeze drying treatment. The self-made fine powder has similar results with the commercial ultrafine powder, but is far lower than the freeze-dried powder.

And (4) detecting the protein content of the mixed coarse powder, the fine powder and the freeze-dried powder prepared in the second example. And (3) adding water into the three kinds of powder respectively to prepare suspension with the solid content of 5%, fully stirring and filtering, diluting the filtrate by 10 times with water, performing ultraviolet scanning on the diluent, and respectively inspecting the ultraviolet absorption at 260nm and 280 nm. The protein content was calculated according to the formula C (mg/mL) ═ 1.45 a280-0.74 a 260.

As shown in table 3 below, as the particle size is further reduced and the freeze-drying process is performed, the ultraviolet absorption peak of the protein in the aqueous solution is enhanced, and the protein content of the freeze-dried powder is significantly enhanced. Indicating that plant cells are further broken and protein release is increased, thus placing higher demands on the preservation of powders with lower particle size.

TABLE 3 protein assay results

Material(s)	Protein concentration (mg/ml)
		Coarse powder mixture	1.3275
Mixing the fine powders	1.7009
		Mixed freeze-dried powder	2.2785

To further examine the effect of wet milling on plant protein release, we treated commercially available ultrafine powder of notoginseng. Preparing two parts of a commercial pseudo-ginseng powder aqueous suspension with 4% of solid content, wherein one part is stirred for 1 hour by common magnetic force, and the other part is ground for 1 hour by a wet method according to the method described in the embodiment one, and the nano-grinding parameters are as follows: zirconium beads: 0.65mm, rotation speed: 3000rpm, cooling water temperature: 5 ℃ is adopted. After centrifugation of the two suspensions in the same way, the supernatants were taken to measure absorbance values at 280nm, respectively, and the results are shown in table 4 below:

TABLE 4 common stirring of Notoginseng radix micropowder and absorption at 280nm after nanometer grinding

Manufacturer (batch number)	Magnetic stirring	Wet grinding
			Wenshanhuaxin (1605007)	0.3068	0.5641
Wenshanhuaxin (1605009)	0.2980	0.4901
			Yunan Dighi (F20160507)	0.3198	0.5495

The results show that the protein release rate of the commercial ultrafine notoginseng powder is greatly improved after wet grinding. The protein release rate of the commercial panax notoginseng powder is far lower than that of the freeze-dried powder.

EXAMPLE six

Grinding Notoginseng radix, radix Panacis Quinquefolii, rhizoma Drynariae, radix aucklandiae, radix Linderae, etc. by the method of example one, and making into fine powder and lyophilized powder according to the general rule of preparation of 4 parts of "Chinese pharmacopoeia" 2015 edition<Oral suspension>Measuring the sedimentation volume ratio by using a method of using a commercially available pseudo-ginseng to surpassThe fine powder served as a control. The operation method is briefly described as follows: weighing 2.5g of each powder, suspending in 50mL of purified water, placing in a stoppered measuring cylinder, sealing, shaking forcefully for 1 minute, and recording the initial height H of the suspension₀After standing for 3 hours, the final height H of the suspension was recorded. The sedimentation volume ratio was calculated as follows: sedimentation volume ratio of H/H₀See table 5 below for results.

TABLE 5 volume ratio of powder sedimentation

The results show that the settling rate of the commercial ultrafine notoginseng powder is not different from that of the self-made fine powder. However, after the freeze-dried powder ground by the wet method is added with water for redissolution, the solid powder of all the traditional Chinese medicinal materials has better suspension effect than the fine powder, so that the freeze-dried powder has better oral experience and avoids waste for daily taking.

EXAMPLE seven

According to the examination method for physical fatigue relieving function of 2003 edition of health Standard of the Ministry of public health of the people's republic of China, a mouse weight swimming experiment is respectively carried out on the panax notoginseng and the American ginseng fine powder and the freeze-dried powder, and the serum urea content and the liver glycogen content of the mouse in the experiment are detected.

144 ICR mice (purchased from Shanghai Slek laboratory animals Co., Ltd.) were randomly divided into three groups, namely a (pure water) negative control group, a Panax notoginseng and Panax quinquefolium fine powder group and a Panax notoginseng and Panax quinquefolium freeze-dried powder group, and each group was randomly divided into 4 groups to respectively carry out a weight swimming test, a serum urea test, a serum lactic acid test and a liver glycogen test.

Except for the negative control group, the mice were continuously administered to the other 2 groups for intragastric administration for 30 days at a dose of 750mg/kg, 0.2ml once. After 30min after the last dose, a small group was randomly selected and subjected to the following experiment:

1. weight bearing swimming experiment

The tail root of the mouse is loaded with 8 percent weight lead wire and then is put into a swimming box (the size of the swimming box is 50cm x 40cm) for swimming, the water depth is not less than 30cm, the water temperature is 25 +/-1 ℃, and the time from the beginning of swimming to death, namely the weight swimming time of the mouse, is recorded.

2. Serum urea detection

Swimming in water at 30 deg.C for 90min, and taking blood after resting for 60 min. The mouse picks eyeballs and collects about 0.5mL of whole blood (without anticoagulant), the whole blood is placed at 4 ℃ for 3h, and the whole blood is centrifuged at 8000rpm for 5min to take serum for testing (full-automatic biochemical analyzer).

3. Serum lactate detection

Swimming in water at 30 deg.C for 10min without load and stopping. Blood is collected before swimming, blood is collected immediately after swimming, blood is collected after 20min of swimming, and 100uL of blood is collected from inner canthus of a mouse by a capillary tube to be detected (a full-automatic biochemical analyzer).

4. Liver glycogen assay

Rinsing liver with physiological saline, drying with filter paper, precisely weighing liver tissue, collecting and processing according to determination kit method, and freezing the rest sample at-20 deg.C for use.

The test result shows that:

(1) the weight swimming time of the freeze-dried powder group, the fine powder group and the negative control group is 413.45 +/-133.90 s, 307.91 +/-97.09 s and 272.58 +/-110.13 s respectively. The weight swimming time of the freeze-dried powder group is obviously longer than that of the negative control group, and the difference has statistical significance (P < 0.05), which indicates that the freeze-dried powder has the function of prolonging the weight swimming time of the mice. The swimming time with load of the fines group was longer than that of the negative control group, but there was no significant difference (P > 0.05).

(2) The Blood Urea Nitrogen (BUN) contents of the lyophilized powder group, the fine powder group and the negative control group are respectively 8.81 + -1.52 mmol/L, 9.51 + -1.23 mmol/L and 10.18 + -0.97 mmol/L. The BUN concentration level of the freeze-dried powder group is obviously lower than that of the negative control group, the difference has statistical significance (P < 0.05), and the freeze-dried powder has the function of reducing BUN. The BUN concentration level of the fines group was lower than that of the negative control group, but there was no significant difference (P > 0.05).

(3) Before swimming, after swimming and after swimming rest for 20min, the blood lactic acid content of the freeze-dried powder group, the fine powder group and the negative control group has no significant difference (P > 0.05).

(4) The liver glycogen content level of the freeze-dried powder group is obviously lower than that of the negative control group, the difference has statistical significance (P < 0.05), and the freeze-dried powder A has the effect of reducing liver glycogen. The liver glycogen content level of the fine powder group is lower than that of the negative control group, but no significant difference exists (P > 0.05).

The above description of the embodiments is only intended to facilitate the understanding of the core ideas of the present invention. It should be noted that, for those skilled in the art, it is possible to make several improvements and modifications to the solid powder composition of the present invention and the method for preparing the same without departing from the principle of the present invention, but these improvements and modifications also fall within the scope of the claims of the present invention.

Claims

1. A solid powder composition of plant Chinese medicinal materials is prepared by adding water to dissolve to form stable suspension, and standing the suspension for 3 hr to obtain a sedimentation volume ratio of not less than 0.4, preferably not less than 0.45, and even not less than 0.8.

2. The solid powder composition according to claim 1, having a water content of <5 wt.%, preferably <3 wt.%.

3. The solid powder composition of claim 1 or 2, which is notoginseng and/or american ginseng.

4. The solid powder composition of claim 1 or 2, which is a combination of notoginseng and american ginseng, in a mass ratio of 0.5-2:1, preferably 1: 1.

5. The solid powder composition according to claim 4, which is a lyophilized powder having a protein content of not less than 2mg/ml in an aqueous solution having a solid content of 5%.

6. A process for preparing the solid powder composition according to any one of claims 1 to 5, comprising the steps of:

(2) passing the coarse powder throughFine powder process, pulverizing to particle size D₉₀Fine powder with the particle size of less than or equal to 100 mu m,

(4) drying the superfine powder suspension.

7. The method of claim 6, wherein the coarse powder process uses a general pulverizer, and the fine powder process uses a jet mill.

8. The method of claim 6 or 7, wherein the ultra-fine process is further pulverizing the plant Chinese medicinal fine powder by wet grinding in a suitable solvent, preferably pure water, preferably using a sand mill or a high pressure homogenizer.

9. The method of claim 6, wherein drying is selected from spray drying and freeze drying, preferably freeze drying.

10. A method for preparing a solid powder composition comprising Panax notoginseng and Panax quinquefolium, comprising the steps of:

(4) adding water with the mass volume of 5-20 times of the fine powder of the pseudo-ginseng and the American ginseng, uniformly mixing, placing in a sand mill, and further carrying out superfine grinding until the particle size of the powder is D₁₀≤5μm，D₅₀≤15μm，D₉₀≤30μm，

(5) The powder suspension was collected and dried on a lyophilizer.

11. A health food for relieving physical fatigue, comprising the solid powder composition of claim 4 or 5, or the solid powder composition directly obtained by the method of claim 10.