CN107669720A - Compound ginseng ganoderma spove powder micro-capsule and preparation method thereof - Google Patents
Compound ginseng ganoderma spove powder micro-capsule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of compound ginseng ganoderma spove powder micro-capsule and preparation method thereof, it belongs to drugs and health care products technical field.A kind of compound ginseng ganoderma spove powder micro-capsule, it is characterised in that it is to be prepared by following raw materials by the parts by weight：15 ~ 30 parts of ginseng water extract, 15 ~ 30 parts of ganoderma spove powder, 10 ~ 50 parts of beta cyclodextrin, 10 ~ 50 parts of mannitol, 1 ~ 10 part of Arabic gum.Micro-capsule stability of the present invention is good, can effectively wrap up ganoderma lucidum spore oil, at utmost solves the problems, such as that ganoderma spove powder is oxidizable rotten.Strengthen the dissolubility of active ingredient, be advantageous to absorbing for ganoderma spove powder and ginseng extract.People, which participates in lucidum spore powder compounding, has relatively strong complementarity, can preferably improve the action effects such as increase immunity.
Description
Technical field
The present invention relates to a kind of compound ginseng ganoderma spove powder micro-capsule and preparation method thereof, it belongs to drugs and health care products
Technical field.
Background technology
Ginseng is Araliaceae herbaceos perennial, is precious Chinese medicine, to have won fame both at home and abroad first of " northeast Triratna ",
China's medicinal history is long.The earliest pharmacy monograph in China《Sheng Nong's herbal classic》Ginseng is classified as top grade, i.e., optimal tonic class.People
Ginseng can be used as medicine, have reinforce vital energy, veins takes off admittedly, the drug effect such as reinforce the spleen to benefit the lung, be promoting production of body fluid and inducing sedation of the mind, be usually used in treating it is physically weak to be taken off, spleen
The diseases such as empty deficiency of food, insomnia of palpitating with fear and heart failure, it is referred to as " kings of hundred medicines ".Ginseng has a variety of of more than 20 kinds of ginsenoside
Biological action, in addition, also rich in polypeptide, volatile oil and various saccharides composition, inorganic elements, vitamin, amino acid, people
Ginseng product is widely used in the fields such as pharmacy industry and body-care.Current study show that ginsenoside composition has antitumor, guarantor
Shield heart cerebrovascular system, protection nervous system, lower dry damage and many-sided pharmacological action such as antiviral.Panaxan is ginseng
In another active component, have include the bioactivity such as immunological regulation, adjunct antineoplastic, hypoglycemic, anti-oxidant.Ginseng is
A kind of strengthening by means of tonics medicine, there are the multiple efficacies such as treatment, health care, nourishing and fit keeping function, be most precious natural tonic.
《Sheng Nong's herbal classic》、《Compendium of Materia Medica》In have very recording certainly to the medical functions of ganoderma lucidum.If any heat-clearing
Removing toxic substances, kidney-nourishing liver protection, nourishing and fit keeping function, strengthen the body resistance to consolidate the constitution, beautifying face and moistering lotion, strengthening the essence of calming the nerves gas and other effects.Therefore, ganoderma lucidum is considered as first-class
Health-care hospital good merchantable brand.Lucidum spore powder is the fine particle that ganoderma lucidum growth and maturity phase ejects from cap, is the reproduction of ganoderma lucidum
Cell, there are whole genetic activities materials of ganoderma lucidum.The amount of its active material is 70 times of ganoderma lucidum entity according to surveying and determination, is primarily present
In ganoderma lucidum spore oil, rich in materials such as essential amino acid, sterol, alkaloid, organic germanium, polysaccharide and triterpenes, it has
The content of machine germanium it is more taller than ginseng go out 4 to 6 times, have been shown to effectively to strengthen human immunological competence and each portion of regulation body
Extension set energy, have and suppress tumour, antiviral, guarantor's kidney protect liver, hypoglycemic, immunological regulation anti-aging and other effects, Reishi sporule
Broken wall is currently mainly used in powder, and it is easier to absorb than the conidia powder of non-broken wall.
For lucidum spore powder oil content up to 20%~30%, the lipid components therefrom extracted are ganoderma lucidum spore oil, are mainly contained
Ganoderma lucidum triterpene compounds, unrighted acid, sterol, vitamin, volatile oil isoreactivity composition；Wherein unrighted acid contains
Amount is more than 60%, and based on the aliphatic acid such as oleic acid, linoleic acid, triterpene compound pharmacological activity is strong, and in ganoderma lucidum spore oil
Main active, lubricant component almost all is overflowed after ganoderma lucidium spore powder wall breaking, but the lubricant component and air contact overflowed
Afterwards, its active component be very easy to oxidation deterioration, peroxide value increase, harmful components increase, leverage product quality and
The period of validity of storage.Therefore how to avoid ganoderma spove powder from aoxidizing, it is extremely important to improve stability.
People, which participates in lucidum spore powder compounding, has relatively strong complementarity, can preferably improve the action effects such as increase immunity,
But because ganoderma spove powder oil content is high, caking and poor fluidity, easily aoxidize, compressibility and less stable, two
Person's compound is in preparation of preparation, it is difficult to prepare the preparations such as tablet.
At present, it has been related to that ganoderma spove powder is anti-oxidant and the document and patent report of preparation technique, main literature
Have：Academic magazine 03 phase in 2015, the prospect of lucidum spore powder New technical use are inquired into；Nutrition and health care and store and processing phase
Print 04 phase in 2009, the preparation of ganoderma spove powder and Study on Its Antioxidant Activity in Vitro；Oil chemistry periodical 09 phase in 2012,
Liposoluble vitamin content and its Study on Its Antioxidant Activity in Vitro in ganoderma lucidum spore oil；Experimental study periodical 04 phase in 2009, spirit
The research that Ganoderma lucidum spore bee glue capsule influences on Serum Lipids in Experimental HypercholesterolemicRats.Patent includes：Chinese patent CN106212818A, a kind of ganoderma lucidum
Tea and preparation method thereof；Chinese patent CN 106173779A, a kind of Reishi sporule solid beverage and preparation method thereof；It is Chinese special
Sharp CN 106173776A, a kind of nourishing medicinal granule of strengthen immunity and preparation method thereof.Do not retrieve using ginseng water extract
Compound ginseng ganoderma spove powder microcapsule formulation report or patent are prepared with ganoderma spove powder.Above patent and document are not
It is related to this patent content.
The content of the invention
Present invention aims at a kind of compound ginseng ganoderma spove powder micro-capsule and preparation method thereof, it solves broken wall
Lucidum spore powder oil content is high, prepared by caking and poor fluidity, easy oxidation, compressibility and less stable, both compounds
It is difficult the technical problem prepared during preparation.
The present invention is invented based on following principles, and ganoderma spove powder usually contains 20%~30% oil component,
Including unrighted acid and triterpenes oily substance, easily oxidation deterioration, simultaneously because bellding influences preparations shaping.This
Invention is studied through lot of experiments and found, in ganoderma spove powder ganoderma lucidum spore oil after hot-water soak can separate out, can be with
As micro-capsule core, and polysaccharide and protein hot-water soak can also extract in ganoderma spove powder, the extraction of ginseng water
Thing also contains more ginseng starch and polysaccharide, protein, can be used as part wall material, at the same through lot of experiments filter out can be with
The wall material combined with conidia powder, ganoderma spove powder and ginseng water extract, beta-schardinger dextrin, mannitol combination, are adding
In the case of entering emulsifying agent, oil-in-water type solution is formed through emulsification, starch, polysaccharide, protein are contained in aqueous phase, it is spray-dried to be
Micro-capsule can be formed.But pass through and investigate, not all be able to can use as the material and emulsifying agent of micro-capsule wall material
In compound ginseng spore powder with crushed sporoderm micro-capsule of the present invention, screened by lot of experiments, the wall material and emulsifying agent material that the present invention filters out
Material can be used for the present invention, reach the effect of compound ginseng spore powder with crushed sporoderm micro-capsule, and envelop rate has well steady more than 80%
The qualitative and physicochemical property of preparation of preparation.
Using 60 ~ 70 DEG C of hot water hot dippings are added in present invention process, make polysaccharide and protein quilt in ganoderma spove powder
Dissolution is extracted, and makes ganoderma lucidum spore oil separate out, ginseng water extract also contains more ginseng starch and polysaccharide, protein,
Then a certain amount of wall material and emulsifying agent are added, constitutes to form micro-capsule primary condition.
This patent prepares compound using materials such as ginseng water extract, ganoderma spove powder and beta-schardinger dextrins as capsule material
The capsule material of the combinations such as ginseng and lucid ganoderma conidia powder micro-capsule, the ginseng water extract, ganoderma spove powder and the beta-schardinger dextrin that are added
Ganoderma lucidum spore oil in ganoderma spove powder can be effectively embedded, forms micro-capsule powder.
In order to realize foregoing invention purpose, the present invention is achieved through the following technical solutions：
A kind of compound ginseng ganoderma spove powder micro-capsule, it is to be prepared by following raw materials by the parts by weight：Ginseng
15 ~ 30 parts of water extract, 15 ~ 30 parts of ganoderma spove powder, 10 ~ 50 parts of beta-schardinger dextrin, 10 ~ 50 parts of mannitol, Arabic gum 1
~ 10 parts.
Above-mentioned compound ginseng ganoderma spove powder micro-capsule, it be prepared by following raw materials by the parts by weight and
Into：20 ~ 25 parts of ginseng water extract, 20 ~ 25 parts of ganoderma spove powder, 25 ~ 35 parts of beta-schardinger dextrin, 25 ~ 35 parts of mannitol, Ah
Draw primary glue 4-6 parts.
Above-mentioned compound ginseng ganoderma spove powder micro-capsule, it be prepared by following raw materials by the parts by weight and
Into：22 parts of ginseng water extract, 22 parts of ganoderma spove powder, 30 parts of beta-schardinger dextrin, 30 parts of mannitol, 5 parts of Arabic gum.
Above-mentioned ginseng water extract is the ginseng extract that fresh ginseng extracts to obtain using cryomilling process.
Above-mentioned ginseng extract preparation method is as follows：Fresh ginseng through over cleaning, drain, be put into high pressure food sterilization machine
Sterilized, crushed with cutmixer, colloid mill fine grinding, juice extractor squeezing, with filling after liquid, freeze-dried machine is freeze-dried to be formed.
Above-mentioned ganoderma spove powder is the conidia powder that Reishi sporule obtains through broken wall.
The preparation method of above-mentioned compound ginseng ganoderma spove powder micro-capsule, this method step are as follows：Weigh and meet institute
Ginseng water extract, beta-schardinger dextrin, the mannitol of parts by weight are stated, is added equivalent to ginseng water extract, beta-schardinger dextrin and sweet
Reveal 60 ~ 70 DEG C of hot water of alcohol 5-8 times of weight of gross weight, stirring, which adds, under 100rpm speed conditions meets the parts by weight
Arabic gum, add the ganoderma spove powder for meeting the parts by weight, with high-shearing dispersion emulsifying machine shearing 5 ~
15min, then homogeneous 3 ~ 5 times under the conditions of 30MPa with homogenizer, obtains micro-capsule emulsion, the emulsion is dried, obtains micro-capsule
Powder.
The preparation method of above-mentioned compound ginseng ganoderma spove powder micro-capsule, take the parts by weight of micro-capsule powder 94 ~ 98.9, hand over
Connection PVP 1 ~ 3 parts by weight, the parts by weight of magnesium stearate 0.1 ~ 3 are well mixed, and tabletting, are coated to obtain tablet.
Above-mentioned drying is spray drying or freeze-drying.
The compound ginseng ganoderma spove powder microcapsule formulation that the present invention obtains has the following advantages that：
（1）Micro-capsule stability of the present invention is good, can effectively wrap up ganoderma lucidum spore oil, and it is easy at utmost to solve ganoderma spove powder
The problem of oxidation deterioration.
（2）Strengthen the dissolubility of active ingredient, be advantageous to absorbing for ganoderma spove powder and ginseng extract.
（3）People, which participates in lucidum spore powder compounding, has relatively strong complementarity, can preferably improve the effect effect such as increase immunity
Fruit.
Embodiment
With reference to instantiation, the present invention is expanded on further.But these embodiments are only limitted to illustrate rather than
To limit the scope of the present invention, the equivalent variations made according to the spirit and scope limited in the claims in the present invention are still fallen within
The scope that the present invention is covered.
Method in following embodiments, it is conventional method unless otherwise instructed.
Percentage composition in following embodiments is weight/mass percentage composition unless otherwise instructed.
Micro-capsule made from following embodiments can use following known method to be detected, and be seen using electron microscope
Micro-capsule size, form are examined, or its particle diameter is determined using Kurt particulate instrument；It is outside using the method measure micro-capsule of extraction grease and micro-
Fat content in capsule, draws envelop rate.Ganoderma spove powder is the conidia powder that Reishi sporule obtains through broken wall.
Embodiment 1
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 15 parts of water extract, 15 parts of ganoderma spove powder, 10 parts of beta-schardinger dextrin, 50 parts of mannitol, 10 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 15g, beta-schardinger dextrin 10g, sweet is weighed
Reveal alcohol 50g, add 60 ~ 70 DEG C of g of hot water 375, stirring addition Arabic gum 10g, adds capsule-core under 100rpm speed conditions
Ganoderma spove powder 15g, with high-shearing dispersion emulsifying machine shear 5min, then with homogenizer under the conditions of 30MPa homogeneous 5
It is secondary, micro-capsule emulsion is obtained, the emulsion spray is dried, obtains micro-capsule powder.Ganoderma lucidum spore oil encapsulating is determined as stated above
Rate is 85.67%.
Described ginseng extract preparation method is as follows：Fresh ginseng through over cleaning, drain, be put into high pressure food sterilization machine
Sterilized, crushed with cutmixer, colloid mill fine grinding, juice extractor squeezing, with filling after liquid, freeze-dried machine is freeze-dried to be formed.
Embodiment 2
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 20 parts of water extract, 20 parts of ganoderma spove powder, 50 parts of beta-schardinger dextrin, 10 parts of mannitol, 1 part of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 20g, beta-schardinger dextrin 50g, sweet is weighed
Reveal alcohol 10g, add 60 ~ 70 DEG C of hot water 480g, stirring addition Arabic gum 1g, adds capsule-core and break under 100rpm speed conditions
Wall lucidum spore powder 20g, with high-shearing dispersion emulsifying machine shear 5min, then homogeneous 4 times under the conditions of 30MPa with homogenizer,
Obtain micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 85.51%.
Embodiment 3
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 25 parts of water extract, 25 parts of ganoderma spove powder, 15 parts of beta-schardinger dextrin, 35 parts of mannitol, 6 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 25g, beta-schardinger dextrin 15g, sweet is weighed
Reveal alcohol 35g, add 60 ~ 70 DEG C of hot water 450g, stirring addition Arabic gum 6g, adds capsule-core and break under 100rpm speed conditions
Wall lucidum spore powder 25g, with high-shearing dispersion emulsifying machine shear 10min, then homogeneous 4 times under the conditions of 30MPa with homogenizer,
Obtain micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 86.34%.
Embodiment 4
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 15 parts of water extract, 20 parts of ganoderma spove powder, 10 parts of beta-schardinger dextrin, 25 parts of mannitol, 5 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 15g, beta-schardinger dextrin 10g, sweet is weighed
Reveal alcohol 25g, add 60 ~ 70 DEG C of hot water 400g, stirring addition Arabic gum 5g, adds capsule-core and break under 100rpm speed conditions
Wall lucidum spore powder 20g, with high-shearing dispersion emulsifying machine shear 10min, then homogeneous 3 times under the conditions of 30MPa with homogenizer,
Obtain micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 86.95%.
Embodiment 5
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 30 parts of water extract, 30 parts of ganoderma spove powder, 15 parts of beta-schardinger dextrin, 22 parts of mannitol, 4 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 30g, beta-schardinger dextrin 15g, sweet is weighed
Reveal alcohol 22g, add 60 ~ 70 DEG C of g of hot water 469, stirring addition Arabic gum 4g, adds capsule-core under 100rpm speed conditions
Ganoderma spove powder 30g, with high-shearing dispersion emulsifying machine shear 10min, then with homogenizer under the conditions of 30MPa homogeneous 3
It is secondary, obtain micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 88.47%.
Described ginseng extract preparation method is as follows：Fresh ginseng through over cleaning, drain, be put into high pressure food sterilization machine
Sterilized, crushed with cutmixer, colloid mill fine grinding, juice extractor squeezing, with filling after liquid, freeze-dried machine is freeze-dried to be formed.
Ganoderma spove powder is the conidia powder that Reishi sporule obtains through broken wall.
Embodiment 6
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 22 parts of water extract, 22 parts of ganoderma spove powder, 30 parts of beta-schardinger dextrin, 30 parts of mannitol, 5 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 22g, beta-schardinger dextrin 30g, sweet is weighed
Reveal alcohol 30g, add 60 ~ 70 DEG C of hot water 492g, stirring addition Arabic gum 5g, adds capsule-core and break under 100rpm speed conditions
Wall lucidum spore powder 22g, with high-shearing dispersion emulsifying machine shear 10min, then homogeneous 4 times under the conditions of 30MPa with homogenizer,
Obtain micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 91.62%.
Embodiment 7
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 15 parts of water extract, 30 parts of ganoderma spove powder, 15 parts of beta-schardinger dextrin, 30 parts of mannitol, 10 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 15g, beta-schardinger dextrin 15g, sweet is weighed
Reveal alcohol 30g, add 60 ~ 70 DEG C of hot water 480g, stirring addition Arabic gum 10g, adds capsule-core under 100rpm speed conditions
Ganoderma spove powder 30g, with high-shearing dispersion emulsifying machine shear 5min, then with homogenizer under the conditions of 30MPa homogeneous 5
It is secondary, obtain micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 88.13%.
Embodiment 8
The compound ginseng ganoderma spove powder micro-capsule of the present invention, can by micro-capsule powder 98.9g prepared by embodiment 1-7, hand over
Connection PVP 1g, magnesium stearate 0.1g are well mixed, tabletting, coating.
Embodiment 9
The compound ginseng ganoderma spove powder micro-capsule of the present invention, can be by micro-capsule powder 94g prepared by embodiment 1-7, crosslinking
PVP 3g, magnesium stearate 3g are well mixed, tabletting, coating.
Embodiment 10
The compound ginseng ganoderma spove powder micro-capsule of the present invention, can be by micro-capsule powder 96g prepared by embodiment 1-7, crosslinking
PVP 3g, magnesium stearate 1g are well mixed, tabletting, coating.
Embodiment 11
The compound ginseng ganoderma spove powder micro-capsule of the present invention, it is to be prepared by following raw material by the parts by weight：People
Join 30 parts of water extract, 15 parts of ganoderma spove powder, 30 parts of beta-schardinger dextrin, 20 parts of mannitol, 5 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 30g, beta-schardinger dextrin 30g, sweet is weighed
Reveal alcohol 20g, add 60 ~ 70 DEG C of hot water 480g, the stirring addition Arabic gum 5g under 100rpm speed conditions, add broken wall spirit
Ganoderma lucidum spore powder 15g, 15min is sheared with high-shearing dispersion emulsifying machine, then homogeneous 5 times under the conditions of 30MPa with homogenizer, is obtained
Micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 89.34%.
Embodiment 12
The compound ginseng ganoderma spove powder micro-capsule of the present invention, raw material are made up of the component of following parts by weight content：Ginseng water
25 parts of extract, 25 parts of ganoderma spove powder, 20 parts of beta-schardinger dextrin, 25 parts of mannitol, 5 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 25g, beta-schardinger dextrin 20g, sweet is weighed
Reveal alcohol 25g, add 60 ~ 70 DEG C of hot water 420g, the stirring addition Arabic gum 5g under 100rpm speed conditions, add broken wall spirit
Ganoderma lucidum spore powder 25g, 10min is sheared with high-shearing dispersion emulsifying machine, then homogeneous 5 times under the conditions of 30MPa with homogenizer, is obtained
Micro-capsule emulsion.The emulsion spray is dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 90.76%.
Embodiment 13
The compound ginseng ganoderma spove powder micro-capsule of the present invention, raw material are made up of the component of following parts by weight content：Ginseng water
20 parts of extract, 25 parts of ganoderma spove powder, 25 parts of beta-schardinger dextrin, 25 parts of mannitol, 5 parts of Arabic gum.
Preparation method comprises the following steps：By weight percentage, ginseng water extract 20g, beta-schardinger dextrin 25g, sweet is weighed
Reveal alcohol 25g, add 60 ~ 70 DEG C of hot water 490g, the stirring addition Arabic gum 5g under 100rpm speed conditions, add broken wall spirit
Ganoderma lucidum spore powder 25g, 15min is sheared with high-shearing dispersion emulsifying machine, then homogeneous 5 times under the conditions of 30MPa with homogenizer, is obtained
Micro-capsule emulsion.The emulsion is freeze-dried, obtains micro-capsule powder, measure ganoderma lucidum spore oil envelop rate is 90.85%.
Embodiment 14
Influence factor is tested
The compound ginseng ganoderma spove powder micro-capsule as made from embodiment 1-7, embodiment 11-13 methods and broken wall spirit are taken respectively
A kind of ten sample of Ganoderma lucidum spore powder is appropriate, is carried out as follows hot test, exposure experiments to light respectively：
（1）Hot test
Sample is respectively placed in transparent sealing ampoule bottle, is placed at 60 DEG C 10 days, is determined the 0th day, the 5th day, the 10th day respectively
The acid value and peroxide value of sample.
As a result：Contrasted with 0 day sample, ganoderma spove powder acid value and peroxide value rise change are obvious；Compound ginseng
Ganoderma spove powder micro-capsule acid value and peroxide value only change by a small margin, unobvious are raised, with ganoderma spove powder phase
Than significant difference, illustrate that compound ginseng ganoderma spove powder micro-capsule is more more stable than ganoderma spove powder under the high temperature conditions.
（2）Exposure experiments to light
Sample is respectively placed in transparent sealing ampoule bottle, is placed in the lighting box equipped with fluorescent lamp, in 4500 ± 500LX illuminance
Under conditions of place 10 days, determine the 0th day, the 5th day and the 10th day sample acid value and peroxide value.
As a result：Contrasted with 0 day sample, ganoderma spove powder acid value and peroxide value rise change are obvious；Compound ginseng
Ganoderma spove powder micro-capsule acid value and peroxide value are without significant change, the significant difference compared with ganoderma spove powder, explanation
Compound ginseng ganoderma spove powder micro-capsule is more more stable than ganoderma spove powder under illumination condition.
Embodiment 15
Stability test
The compound ginseng ganoderma spove powder micro-capsule as made from embodiment 1-7, embodiment 11-13 methods is taken respectively, is investigated multiple
The situation of change of Fang Rencan ganoderma spove powder micro-capsules Reishi sporule oil content under the conditions of accelerated test.
Sample places condition：
Temperature：37 ± 1 DEG C, relative humidity：75%
Compound ginseng ganoderma spove powder micro-capsule accelerated test, with the extension of period of storage, the items of ganoderma lucidum spore oil refer to
Mark has no significant change, and illustrates that product stability is good.
Embodiment 16
Micro-capsule detection method
The compound ginseng ganoderma spove powder micro-capsule as made from embodiment 1-7, embodiment 11-13 methods is detected.
1. electron microscope method
100mg compound ginseng ganoderma spove powder microencapsulated samples are weighed, for testing electronic microscope, microencapsulated sample is put into
In electron microscope, with electron microscope observation micro-capsule size and form.
As a result：Size is about 2 ~ 15 μm, and entirety is in spherical, surface is more smooth, and there is depression on surface, fine and close, flawless hole.
2. using the method measure microencapsulation rate of extraction grease
（1）The measure of micro-capsule surface Reishi sporule oil content
Weigh microencapsulated sample 10g（m1）It is put into dry triangular flask, by 3 additions of 100ml petroleum ethers point, vibrates 2 every time
Min, filtering, merging filtrate.Filtrate is moved into the round-bottomed flask dried and weighed（m2）, oil is sloughed with rotary evaporator
Ether, place into 60 DEG C of baking ovens and dry to constant weight（m3）, surface Reishi sporule oil content（%）=（m3-m2）/m1×100.
As a result：After measured, Reishi sporule oil content in surface is 0.4%.
（2）The measure of ganoderma lucidum spore oil total amount in micro-capsule
Weigh microencapsulated sample 10g（m1）It is put into dry triangular flask, adds 100mL hot water, after sample is fully dissolved, adds
After 100mL petroleum ethers fully extract, extract is moved into the round-bottomed flask dried and weighed（m2）, repeat to be extracted twice, close
And extract, petroleum ether is sloughed with rotary evaporator, places into 60 DEG C of baking ovens and dries to constant weight（m3）, ganoderma lucidum spore oil total content
（%）=（m3-m2）/m1×100.
As a result：After measured, ganoderma lucidum spore oil total amount is 3.72% in micro-capsule.
（3）The measure of microencapsulation rate
Microencapsulation rate（%）=（1- surface oil contents/total oil content）×100
As a result：
| Sample | Surface Reishi sporule oil content % | Ganoderma lucidum spore oil total amount % in micro-capsule | Microencapsulation rate % |
| Compound ginseng ganoderma spove powder micro-capsule | 0.03-0.04% | 3.70-3.79% | 85.51-91.62% |
After measured, compound ginseng ganoderma spove powder microencapsulation rate is 85.51-91.62%, it was demonstrated that ginseng water extract, is broken
The capsule material of the combination such as wall lucidum spore powder and beta-schardinger dextrin can effectively embed ganoderma lucidum spore oil in ganoderma spove powder.
Claims (9)
1. compound ginseng ganoderma spove powder micro-capsule, it is characterised in that it be prepared by following raw materials by the parts by weight and
Into：15 ~ 30 parts of ginseng water extract, 15 ~ 30 parts of ganoderma spove powder, 10 ~ 50 parts of beta-schardinger dextrin, 10 ~ 50 parts of mannitol, Ah
Draw primary 1 ~ 10 part of glue.
2. compound ginseng ganoderma spove powder micro-capsule according to claim 1, it is characterised in that it is by following raw materials
It is prepared by the parts by weight：20 ~ 25 parts of ginseng water extract, 20 ~ 25 parts of ganoderma spove powder, beta-schardinger dextrin 25 ~
35 parts, 25 ~ 35 parts of mannitol, Arabic gum 4-6 parts.
3. compound ginseng ganoderma spove powder micro-capsule according to claim 1, it is characterised in that it is by following raw materials
It is prepared by the parts by weight：22 parts of ginseng water extract, 22 parts of ganoderma spove powder, 30 parts of beta-schardinger dextrin, sweet dew
30 parts of alcohol, 5 parts of Arabic gum.
4. the compound ginseng ganoderma spove powder micro-capsule according to claim 1,2 or 3, it is characterised in that the ginseng water
Extract is the ginseng extract that fresh ginseng extracts to obtain using cryomilling process.
5. compound ginseng ganoderma spove powder micro-capsule according to claim 4, it is characterised in that described ginseng extraction
Thing preparation method is as follows：Fresh ginseng through over cleaning, drain, be put into high pressure food sterilization machine and sterilized, crushed with cutmixer,
Colloid mill refines, and juice extractor squeezing, with filling after liquid, freeze-dried machine is freeze-dried to be formed.
6. the compound ginseng ganoderma spove powder micro-capsule according to claim 1,2 or 3, it is characterised in that described broken wall
Lucidum spore powder is the conidia powder that Reishi sporule obtains through broken wall.
7. the preparation method of the compound ginseng ganoderma spove powder micro-capsule according to claim 1,2 or 3, it is characterised in that
This method step is as follows：Weigh ginseng water extract, beta-schardinger dextrin, the mannitol for meeting the parts by weight, add equivalent to
60 ~ 70 DEG C of hot water of 5-8 times of ginseng water extract, beta-schardinger dextrin and mannitol gross weight weight, under 100rpm speed conditions
Stirring adds the Arabic gum for meeting the parts by weight, adds the ganoderma spove powder for meeting the parts by weight, uses
High-shearing dispersion emulsifying machine shears 5 ~ 15min, then homogeneous 3 ~ 5 times under the conditions of 30MPa with homogenizer, obtains micro-capsule emulsification
Liquid, the emulsion is dried, obtain micro-capsule powder.
8. the preparation method of compound ginseng ganoderma spove powder micro-capsule according to claim 7, it is characterised in that take micro-
The parts by weight of capsule powder 94 ~ 98.9, the parts by weight of PVPP 1 ~ 3, the parts by weight of magnesium stearate 0.1 ~ 3 are well mixed, tabletting, coating
Obtain tablet.
9. the preparation method of compound ginseng ganoderma spove powder micro-capsule according to claim 7, it is characterised in that described
Drying for spray drying or freeze-drying.
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| CN101524377A (en) * | 2009-04-10 | 2009-09-09 | 南京师范大学 | Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof |
| CN105998093A (en) * | 2016-07-12 | 2016-10-12 | 周庆新 | Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof |
| CN106692239A (en) * | 2016-09-01 | 2017-05-24 | 三门鸿禾瑞堂中药材专业合作社 | Ginseng and ganoderma lucidum spore powder tablets and preparation method thereof |
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| CN101524377A (en) * | 2009-04-10 | 2009-09-09 | 南京师范大学 | Composite of wall-breaking lucidum spore powder and cyclodextrin and preparation method thereof |
| CN105998093A (en) * | 2016-07-12 | 2016-10-12 | 周庆新 | Blood-glucose-lowering ganoderma lucidum instant micro-encapsulated preparation and preparation method thereof |
| CN106692239A (en) * | 2016-09-01 | 2017-05-24 | 三门鸿禾瑞堂中药材专业合作社 | Ginseng and ganoderma lucidum spore powder tablets and preparation method thereof |
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| CN116270769A (en) * | 2022-12-29 | 2023-06-23 | 康道生物（南通）有限公司 | Preparation method of ganoderma lucidum spore extract and ganoderma lucidum spore powder capsule |
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