CN111450112A - Preparation method of unitary chlorine dioxide water solution for oral disinfection - Google Patents

Preparation method of unitary chlorine dioxide water solution for oral disinfection Download PDF

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CN111450112A
CN111450112A CN202010276546.5A CN202010276546A CN111450112A CN 111450112 A CN111450112 A CN 111450112A CN 202010276546 A CN202010276546 A CN 202010276546A CN 111450112 A CN111450112 A CN 111450112A
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chlorine dioxide
aqueous solution
stabilizer
disinfection
dioxide aqueous
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邬力
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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  • General Chemical & Material Sciences (AREA)
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Abstract

The invention belongs to the field of disinfection chemistry and chemical engineering, and discloses a method for preparing a unitary chlorine dioxide aqueous solution for oral disinfection, which can be widely applied to the fields of daily chemical medical treatment and the like and can be used for oral disinfection such as mouth wash, root canal treatment and the like. The invention aims to provide a stabilizer formula and a preparation method thereof, so that the chlorine dioxide aqueous solution can be directly used for oral disinfection, the proper pH value is kept at the concentration, and the stability is higher (the concentration reduction rate is less than 10 percent under the constant temperature test condition of 14 days at 54 ℃). The formula of the stabilizer consists of one or two or more of ammonium pentaborate, metaboric acid, boron trioxide, maleic acid and sodium tetraphenylborate. The method comprises the steps of preparing chlorine dioxide by any conventional method, dissolving the chlorine dioxide into distilled water with the concentration range of 50 mg/l-200 mg/l, pouring the stabilizer into a chlorine dioxide aqueous solution according to a proportion, stirring for about 2 minutes, standing, and taking clear liquid. The mass ratio of the chlorine dioxide aqueous solution to the stabilizer is 10000: 0.15-1000: 150. through tests and detection, the product has the pH value of more than 4, small stimulation to human bodies, high stability and convenient storage.

Description

Preparation method of unitary chlorine dioxide water solution for oral disinfection
Technical Field
The invention belongs to the field of disinfection chemistry and chemical engineering, and particularly relates to a method for preparing a unitary chlorine dioxide aqueous solution for oral disinfection, which can be widely applied to the fields of daily chemical medical treatment and the like and can be used for oral disinfection such as mouthwash, root canal treatment and the like.
Background
Chlorine dioxide is a safety level disinfectant of grade A1 which is recognized by the world health organization and the world food and agricultural organization. The chlorine dioxide water solution with lower concentration can be applied to the disinfection of human oral cavity. The chlorine dioxide aqueous solution with the concentration is preferably unitary, has the use requirement of convenience, is convenient to carry after being opened and is easy to be accepted by consumers. Secondly, the pH value cannot be lower than 4, otherwise, the irritation to the human body is large. Finally, the requirement process is simple, and the stability meets the requirement of the disinfection technical specification.
Disclosure of Invention
The invention aims to provide a stabilizer formula and a manufacturing method, so that the chlorine dioxide aqueous solution can be directly used for oral disinfection, the proper pH value is kept at the concentration, and the stability is higher (the concentration reduction rate is less than 10 percent under the constant temperature test condition of 14 days at 54 ℃) [1 ].
The technical scheme is as follows: a method for preparing unitary chlorine dioxide aqueous solution for oral disinfection is characterized in that: the stabilizer formula consists of one or two or more of ammonium pentaborate, metaboric acid, diboron trioxide, maleic acid and sodium tetraphenylborate, and the method for preparing the unitary chlorine dioxide aqueous solution by using the stabilizer.
The method comprises the steps of preparing chlorine dioxide by any conventional method, dissolving the chlorine dioxide into distilled water, pouring the stabilizer into the chlorine dioxide aqueous solution according to a proportion, stirring for about 2 minutes, standing, and taking clear liquid, wherein the concentration of the chlorine dioxide aqueous solution ranges from 50mg/l to 200 mg/l. The mass ratio of the chlorine dioxide aqueous solution to the stabilizer is 10000: 0.15-1000: 150.
the stabilizer of the invention is composed of one or two or more than two of ammonium pentaborate, metaboric acid, boron trioxide, maleic acid and sodium tetraphenylborate:
ammonium pentaborate, molecular formula NH4B5O8, molecular weight 200.08, CAS number: 12007-89-5
Metaboric acid, molecular formula HBO2, molecular weight 43.82, CAS number: 13460-50-9
Boron trioxide, molecular formula B2O3, molecular weight 69.62, CAS number: 1303-86-2
Maleic acid, formula C4H4O4Molecular weight 116.07, CAS number: 110-16-7
Sodium tetraphenylborate, molecular formula C24H20BNa, molecular weight 342.2, CAS number 143-66-8
Chlorine dioxide, molecular formula ClO2,Molecular weight 67.46, CAS number: 10049-04-4
The preparation method comprises the following steps: firstly, preparing a chlorine dioxide aqueous solution according to any one of the prior technologies, then putting the stabilizer into the chlorine dioxide aqueous solution, stirring for about 2 minutes, standing, and taking clear liquid to obtain the product.
The invention has the advantages that: the stability meets the requirements of national disinfection technical specifications: under the constant temperature test condition of 54 ℃ and 14 days,
the concentration decrease rate is less than 10% (see Table 1)
A pH of greater than 4.0 (100 mg/l concentration pH = 5.0)
The stability and the proper pH value can be kept in a wider concentration range, so that the application field of the disinfectant is expanded, and the disinfectant can be used for oral disinfection, hand disinfection, object surface disinfection, air disinfection and the like.
The process is simple, the cost is relatively low, and the market demand is met.
TABLE 1 chlorine dioxide stability measurement results
Figure 243705DEST_PATH_IMAGE002
The application advantages are as follows: the product of the invention can be used for disinfecting the object surface and the human body (the appropriate pH value has small corrosive irritation), thereby greatly improving the application value of the product.
The mechanism for stabilizing the chlorine dioxide aqueous solution is briefly described as follows:
chlorine dioxide is a highly electron-deficient compound, which is composed of oxygen atoms and chlorine atoms with large electronegativity, and when the chlorine dioxide is in an electron-rich compound and electron clouds in the molecules have certain mobility, intermolecular attraction is easy to form, and intermolecular chelation and complexation can be formed under certain conditions, so that intermolecular force is further enhanced, and as a result, the chlorine dioxide molecules are difficult to escape, so that the stability of the aqueous solution is enhanced.
Detailed description of the preferred embodiments
The first embodiment is as follows: 100kg of distilled water is prepared, and chlorine dioxide gas generated by a chlorine dioxide generator is introduced into the water to form chlorine dioxide absorption liquid with the final concentration of 100 mg/l. Then 10g of the stabilizer of the invention boron trioxide is gradually poured into the absorption liquid, and stirred for 2 minutes, and then the mixture is kept stand, and the clear liquid is taken out, sealed and protected from light.
The second embodiment: 50kg of distilled water was prepared, 1kg of 2% sodium chlorite aqueous solution was mixed with 0.01kg of citric acid in distilled water to produce chlorine dioxide, and 10g of sodium tetraphenylborate as a stabilizer of the present invention was gradually added to the solution while stirring for 2 minutes. Standing, collecting supernatant, sealing, and storing in dark place.
The third embodiment is as follows: the product of the invention is applied to oral disinfection and deodorization: according to the implementation example method, the chlorine dioxide aqueous solution with the concentration of 200mg/l is prepared, then the chlorine dioxide aqueous solution with the concentration of 80mg/l is diluted by distilled water and packaged by a polyethylene spray bottle for oral cleaning, disinfection and deodorization.
Note that 1 Disinfection Specification 2002 edition.

Claims (3)

1. A method for preparing unitary chlorine dioxide aqueous solution for oral disinfection is characterized in that: the product is prepared by mixing a stabilizer and a chlorine dioxide aqueous solution according to a certain mass ratio and certain steps, wherein the mass ratio of the chlorine dioxide aqueous solution to the stabilizer is 10000: 0.15-1000: 150.
2. The method of claim 1, wherein the stabilizer is: is prepared from one or two or more of ammonium pentaborate, metaboric acid, diboron trioxide, maleic acid and sodium tetraphenylborate through mixing.
3. A method for producing an aqueous monobasic chlorine dioxide solution useful for oral disinfection according to claim 1, wherein the method comprises the steps of: firstly, chlorine dioxide is produced by any conventional method and dissolved in distilled water, the concentration of the chlorine dioxide is 50 mg/l-200 mg/l, then the stabilizing agent is added into the chlorine dioxide aqueous solution according to a proportion, the mixture is stirred for about 2 minutes and then stands, and clear liquid is obtained.
CN202010276546.5A 2020-04-10 2020-04-10 Preparation method of unitary chlorine dioxide water solution for oral disinfection Pending CN111450112A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113171308A (en) * 2021-04-23 2021-07-27 河北科技大学 Solid composition for denture cleaning, denture cleaning effervescent tablet and preparation method thereof
NL2033888B1 (en) * 2022-09-02 2024-03-21 Institute Of Feed Res Chinese Academy Of Agricultural Sciences Chlorine dioxide solution disinfectant used for prevention and control of african swine fever and usable in presence of livestock, preparation method and use thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1143604A (en) * 1996-05-29 1997-02-26 江西荣欣高新技术公司 Process for producing stable chlorine dioxide
CN1454837A (en) * 2003-04-22 2003-11-12 贵州大学 Method of preparing stable chloride dioxide
CN1923004A (en) * 2006-09-20 2007-03-07 龙庆厚 Method for producing monobasic chlorine dioxide disinfector by improving content and stability greatly
CN103125521A (en) * 2011-11-30 2013-06-05 安徽省蓝天化工有限公司 Preparation method of oxidability germicide and algicide agent
CN104106596A (en) * 2013-04-22 2014-10-22 吕世鹏 Process and device for preparing stable high-concentration sterilization disinfection preparation
CN110352980A (en) * 2019-06-24 2019-10-22 大庆石油管理局有限公司 Chlorine dioxide releasing agent and preparation method thereof
CN110692648A (en) * 2019-09-09 2020-01-17 龙泽云 Method for preparing high-concentration high-stability unitary chlorine dioxide aqueous solution

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1143604A (en) * 1996-05-29 1997-02-26 江西荣欣高新技术公司 Process for producing stable chlorine dioxide
CN1454837A (en) * 2003-04-22 2003-11-12 贵州大学 Method of preparing stable chloride dioxide
CN1923004A (en) * 2006-09-20 2007-03-07 龙庆厚 Method for producing monobasic chlorine dioxide disinfector by improving content and stability greatly
CN103125521A (en) * 2011-11-30 2013-06-05 安徽省蓝天化工有限公司 Preparation method of oxidability germicide and algicide agent
CN104106596A (en) * 2013-04-22 2014-10-22 吕世鹏 Process and device for preparing stable high-concentration sterilization disinfection preparation
CN110352980A (en) * 2019-06-24 2019-10-22 大庆石油管理局有限公司 Chlorine dioxide releasing agent and preparation method thereof
CN110692648A (en) * 2019-09-09 2020-01-17 龙泽云 Method for preparing high-concentration high-stability unitary chlorine dioxide aqueous solution

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
薛广波: "《现代消毒学》", 31 July 2002, 人民军医出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113171308A (en) * 2021-04-23 2021-07-27 河北科技大学 Solid composition for denture cleaning, denture cleaning effervescent tablet and preparation method thereof
NL2033888B1 (en) * 2022-09-02 2024-03-21 Institute Of Feed Res Chinese Academy Of Agricultural Sciences Chlorine dioxide solution disinfectant used for prevention and control of african swine fever and usable in presence of livestock, preparation method and use thereof

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