CN111407753A - 具有免疫疾病治疗效果的新型化合物及其应用 - Google Patents

具有免疫疾病治疗效果的新型化合物及其应用 Download PDF

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CN111407753A
CN111407753A CN202010321725.6A CN202010321725A CN111407753A CN 111407753 A CN111407753 A CN 111407753A CN 202010321725 A CN202010321725 A CN 202010321725A CN 111407753 A CN111407753 A CN 111407753A
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cells
disease
present
diseases
immune
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曹美罗
申東润
朴盛焕
梁哲宇
崔钟荣
朴潣廷
孙惠辰
李圣希
李善瑛
金恩敬
金在庚
李昇勋
朴星赫
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Catholic University of Korea
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    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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CN202010321725.6A 2014-04-29 2015-04-29 具有免疫疾病治疗效果的新型化合物及其应用 Pending CN111407753A (zh)

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US (2) US20170114008A1 (enExample)
EP (1) EP3130582B8 (enExample)
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CA (1) CA2946516C (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113907047A (zh) * 2021-12-13 2022-01-11 天津医科大学总医院空港医院 一种自身抗原表位诱导的eam小鼠模型的建立方法
WO2024001152A1 (zh) * 2022-06-28 2024-01-04 广东省人民医院 胶体锰佐剂在建立原发性干燥综合征动物模型中的应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3043785T3 (da) 2013-09-13 2021-11-15 Univ Chiba Nat Univ Corp Anvendelse af r-ketamin og salt deraf som lægemidler
KR101949451B1 (ko) 2015-10-13 2019-05-10 주식회사 이노파마스크린 염증성 장 질환 및 아토피 피부염 치료용 조성물
WO2018133139A1 (zh) 2017-01-21 2018-07-26 宁波知明生物科技有限公司 芍药苷-6'-o-苯磺酸酯在治疗干燥综合征的应用
US11370748B2 (en) 2017-09-05 2022-06-28 1Globe Biomedical Co., Ltd. Therapeutics for central nervous system disorders
WO2019160057A1 (ja) * 2018-02-15 2019-08-22 国立大学法人千葉大学 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物
AU2019334202A1 (en) 2018-09-06 2021-03-25 Innopharmascreen, Inc. Methods and compositions for treatment of asthma or parkinson's disease
KR102147802B1 (ko) 2018-11-07 2020-08-25 가톨릭대학교 산학협력단 신규 화합물 및 칼시뉴린 억제제를 포함하는 이식 거부 반응 또는 이식 거부 질환의 예방 및 치료용 조성물
US20220033489A1 (en) * 2018-12-04 2022-02-03 The Children's Medical Center Corporation Methods and compositions for treating asthma
KR102316961B1 (ko) * 2020-01-29 2021-10-26 프라비바이오 주식회사 면역억제제로서의 벤젠 유도체의 면역억제용 약학적 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110053941A1 (en) * 2007-11-30 2011-03-03 Newlink Genetics IDO Inhibitors
US20130095140A1 (en) * 2011-01-07 2013-04-18 Elcelyx Therapeutics, Inc. Biguanide Compositions and Methods of Treating Metabolic Disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183956A (en) * 1975-11-05 1980-01-15 William H. Rorer, Inc. Method for treating gastrointestinal spasms, gastrointestinal hyperacidity and hypertensive disorders with amidinoureas
US4060635A (en) * 1975-03-31 1977-11-29 William H. Rorer, Inc. Amidinoureas for treating diarrhea
US8053477B2 (en) * 2002-03-29 2011-11-08 University Of Maryland, Baltimore Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
US7622117B2 (en) 2002-04-17 2009-11-24 Dynamis Therapeutics, Inc. 3-deoxyglucosone and skin
ES2586837T3 (es) * 2009-08-03 2016-10-19 University Of Miami Método para la expansión in vivo de linfocitos T reguladores
KR101136045B1 (ko) * 2009-11-16 2012-04-18 한국화학연구원 N1-(펜에틸)-n2-치환된 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물
EP2522653A4 (en) * 2010-01-06 2013-06-12 Hanall Biopharma Co Ltd BIGUANIDE DERIVATIVE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE BIGUANIDE DERIVATIVE AS AN ACTIVE SUBSTANCE
US8809541B2 (en) 2010-08-25 2014-08-19 Neopharm Co., Ltd. Heterocyclic compound, and composition for treating inflammatory diseases using same
KR101432246B1 (ko) * 2011-09-20 2014-08-21 가톨릭대학교 산학협력단 메포민을 포함하는 자가면역질환 예방 및 치료용 조성물
CN102698266A (zh) * 2012-05-15 2012-10-03 中国医学科学院北京协和医院 Cd200在制备系统性红斑狼疮治疗药物中的应用
KR101432892B1 (ko) 2012-09-17 2014-08-21 가톨릭대학교 산학협력단 메트포민을 이용한 루프스를 포함하는 면역질환의 예방 또는 치료용 조성물
KR101613371B1 (ko) * 2014-11-10 2016-04-18 가톨릭대학교 산학협력단 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110053941A1 (en) * 2007-11-30 2011-03-03 Newlink Genetics IDO Inhibitors
US20130095140A1 (en) * 2011-01-07 2013-04-18 Elcelyx Therapeutics, Inc. Biguanide Compositions and Methods of Treating Metabolic Disorders

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113907047A (zh) * 2021-12-13 2022-01-11 天津医科大学总医院空港医院 一种自身抗原表位诱导的eam小鼠模型的建立方法
WO2024001152A1 (zh) * 2022-06-28 2024-01-04 广东省人民医院 胶体锰佐剂在建立原发性干燥综合征动物模型中的应用

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US20170114008A1 (en) 2017-04-27
AU2015254037B2 (en) 2019-03-21
EP3130582B8 (en) 2019-01-02
US20180118668A1 (en) 2018-05-03
CN106458869A (zh) 2017-02-22
KR20150124923A (ko) 2015-11-06
EP3130582A1 (en) 2017-02-15
KR101705446B1 (ko) 2017-02-09
US10100006B2 (en) 2018-10-16
EP3130582B1 (en) 2018-10-10
CA2946516C (en) 2022-02-01
JP2017519723A (ja) 2017-07-20
CA2946516A1 (en) 2015-11-05
AU2015254037A1 (en) 2016-11-17
EP3130582A4 (en) 2017-08-30
JP6462002B2 (ja) 2019-01-30
ES2702337T3 (es) 2019-02-28

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Application publication date: 20200714