CN111406760A

CN111406760A - Synergistic pesticide composition, preparation method and application thereof

Info

Publication number: CN111406760A
Application number: CN201911394352.9A
Authority: CN
Inventors: 周小军; 朱丽燕; 何晓婵; 戴为光; 马赵江
Original assignee: Jinhua Academy of Agricultural Sciences
Current assignee: Jinhua Academy of Agricultural Sciences
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-07-14

Abstract

The invention discloses a synergistic pesticide composition, which comprises an active component and an auxiliary agent; wherein the active components comprise chlorantraniliprole, phoxim and tea seed cake; the mass ratio of the chlorantraniliprole to the phoxim to the tea seed cake is as follows: 1: (0.01-40): (98.99-59); the insecticidal composition has the advantages that the insecticidal composition contains chlorantraniliprole, phoxim and tea seed cakes, has obvious synergistic effect, is more obvious in control effect and low in dosage, and delays the generation of drug resistance of pests.

Description

Synergistic pesticide composition, preparation method and application thereof

Technical Field

The invention relates to the technical field of pesticides, and particularly relates to a synergistic pesticide composition, a preparation method and application thereof.

Background

Chlorantraniliprole has a brand new action mechanism, activates a ryanodine receptor, enables the receptor channel to open in abnormal time, and causes unlimited calcium ion release, calcium reservoir failure, muscle paralysis and final death. The chlorantraniliprole has high efficiency and broad spectrum, can be used for preventing and controlling main pests of rice, can quickly protect the growth of the rice, and has special effect particularly on other pests with resistance to rice pesticides, such as cnaphalocrocis medinalis guenee, chilo suppressalis, tryporyza incertulas and sesamia inferens guenee. In addition, the composition also has good control effect on rice gall midge, rice weevil and rice weevil.

Phoxim is a broad-spectrum organophosphorus insecticide commonly used in production, has a wide insecticidal spectrum and strong knockdown force, is mainly based on contact killing and stomach poisoning effects, has no systemic effect, and is very effective on lepidoptera larvae. The pesticide has short residue period and less residue danger due to unstable light and quick decomposition in the field, but the pesticide has long residue period when applied into the soil, and is suitable for controlling underground pests. The effective components of the traditional pesticide formulation are easy to lose efficacy under the action of external environment such as sunlight and soil pH value, and the like, and the effective period is short, so that the control effect of the pesticide is reduced. The existing preparations containing phoxim on the market all contain a large amount of organic solvents, thus polluting the environment. Therefore, how to develop an environment-friendly formulation which can well compound chlorantraniliprole and phoxim is a technical problem to be solved urgently.

The application No. 2018111471800 patent application indicates that chlorantraniliprole and phoxim can be used alone or in combination as active substances of pesticides to be matched with other auxiliary agents to prepare powder, and the prepared powder is treated by a special coating technology and has the characteristics of quick and stable fertilizer effect and slow and lasting insecticidal effect; the active ingredients used in the invention are all chemical insecticides, have large dosage, mainly play a role in killing insects and have single effect.

Disclosure of Invention

The invention aims to provide a synergistic pesticide composition, which has remarkable synergistic effect among chlorantraniliprole, phoxim and tea seed cakes, has more remarkable control effect and low dosage and delays the generation of drug resistance of pests.

In order to solve the technical problem, the technical scheme of the invention is as follows: a synergistic pesticide composition comprises an active component and an auxiliary agent; wherein the active components comprise chlorantraniliprole, phoxim and tea seed cake.

Preferably, the mass ratio of the chlorantraniliprole to the phoxim to the tea seed cake is as follows:

1：0.01-40：98.99-59。

further preferably, the mass ratio of the chlorantraniliprole to the phoxim to the tea seed cake is 1: (0.03-30): (98.97-69).

More preferably, the weight ratio of the chlorantraniliprole to the phoxim to the tea seed cake is 1: (0.1-10): (98.9-89).

Preferably, the auxiliary agent comprises: binder, dispersant, wetting agent, disintegrant, water, stabilizer, adsorbent, lubricant and solid inert carrier;

the composition comprises the following components in percentage by mass:

the rest auxiliary agent is a solid inert carrier.

The binder in the invention comprises at least one of starch, pregelatinized starch, gelatin, Arabic gum, polyvinylpyrrolidone, methylcellulose, hydroxypropyl methylcellulose, polyethylene glycol, polyvinyl alcohol, glucose and sucrose;

the dispersing agent comprises at least one of alkyl naphthalene sulfonate, a bis (alkyl) naphthalene sulfonate formaldehyde condensate, a naphthalene sulfonate formaldehyde condensate, aryl phenol polyoxyethylene succinate sulfonate, octyl phenol polyoxyethylene ether sulfate, polycarboxylate, sodium lignosulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkyl benzene sulfonic acid calcium salt, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester and fatty alcohol polyoxyethylene ether;

the wetting agent comprises at least one of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, nekal AC, washing powder, sodium lauryl sulfate, Chinese honeylocust fruit powder, silkworm excrement and soapberry powder;

the disintegrating agent comprises at least one of ammonium sulfate, urea, polyvinylpyrrolidone, sodium sulfate, starch, cellulose, sodium bicarbonate, sodium lauryl sulfate, sodium alginate, bentonite and sodium chloride;

the stabilizer comprises at least one of epoxidized soybean oil, epichlorohydrin and triphenyl phosphate.

The total ratio of the stabilizer, the adsorbent and the lubricant in the granules can be 0.1-5%, and the weight ratio of the stabilizer, the adsorbent and the lubricant can be set freely.

The auxiliaries not described in the present invention, for example, the adsorbent and the lubricant, may be selected from those commonly used in the art.

The solid inert carrier is kaolin.

By adopting the technical scheme, the invention has the beneficial effects that: the chlorantraniliprole, the phoxim and the tea seed cake are compounded to have obvious synergistic effect, the dosage is obviously reduced, the generation of drug resistance of pests is delayed, the active ingredients are prepared into granules, the drug effect of the active ingredients is better exerted, and the stability of the granules and the control effect of the pests are obviously improved.

The tea seed cake is residue left after oil extraction of tea seeds, contains flavonol glycoside and tea saponin, has certain fertilizer effect and good insecticidal and bacteriostatic effects.

The invention aims to provide a preparation method of a synergistic pesticide composition, which is characterized in that active components and auxiliary agents are crushed, mixed and granulated to prepare granules, the preparation process steps are simple, and the granules with stable pesticide effect are prepared.

In order to solve the technical problem, the technical scheme of the invention is as follows: the preparation method of the synergistic pesticide composition comprises the following steps:

step one, mixing an active component, a binder, a dispersing agent, a wetting agent, a disintegrating agent, a stabilizing agent, an adsorbent, a lubricant and a solid inert carrier agent, and then carrying out jet milling to obtain a first material with the particle size D90 being less than or equal to 20 microns;

mixing water with the first material and then granulating to obtain a second material with the particle size of 20-80 meshes;

and step three, evaporating the water of the second material at 50-60 ℃ to obtain granules containing chlorantraniliprole, phoxim and tea seed cakes.

The third purpose of the invention is to provide the application of the prepared granules in controlling crop pests.

Preferably, the pests include one of spodoptera litura, ampullaria gigas, wireworm, camellias elephant, grub, cutworm, mole cricket, root eating golden flower worm, root maggot, slug and snail.

The crop comprises one of lotus root, water bamboo, tea tree, rice, wheat, corn, fruit tree, cotton and cruciferous vegetable.

By adopting the technical scheme, the invention has the beneficial effects that: the invention obviously improves the control effect on pests, has small dosage and delays the generation of drug resistance of the pests.

Thereby achieving the above object of the present invention.

Detailed Description

In order to further explain the technical solution of the present invention, the present invention is explained in detail by the following specific examples.

Example 1

The embodiment discloses a synergistic pesticide composition, which comprises the following raw materials in parts by weight:

the mass fraction of the amount of each substance in this step is shown in table 1; the dosage of each substance of the active components is shown in table 2 in detail; the specific materials of the various adjuvants are detailed in Table 3.

The pesticide composition granules prepared in the embodiment are applied to a crop field investigation method with pests, and the field pesticide effect test in the embodiment is carried out as follows:

the population base number of the insects is investigated before the pesticide is applied, the residual population number of the insects is investigated for 1 day, 3 days and 7 days after the pesticide is applied, 10 crops are uniformly investigated in each field for the investigation, and the control effect statistics is carried out.

The effect of the pesticide composition granules prepared in the embodiment on controlling pests in crop fields is detailed in tables 4 to 7.

The solid inert carrier is kaolin.

Example 2

The main differences between the present example and example 1 are detailed in tables 1, 2 and 3, and the specific application method of the pesticide composition granules prepared in the present example is as follows: the active component is prepared according to the ratio of 100a.i.g/hm²The pesticide composition prepared in the example is sprinkled into the corresponding field;

the effect of the granular pesticide composition prepared by the present example on controlling pests in crop fields is detailed in tables 4 to 7.

Example 3

Example 4

Example 5

The main differences between the present example and example 1 are detailed in tables 1, 2 and 3, and the specific application method of the pesticide composition granules prepared in the present example is as follows: the active component is prepared according to the ratio of 100a.i.g/hm²The pesticide composition prepared in this example was sprinkled into the correspondingThe field of (1);

Example 6

Example 7

Example 8

Table 1 list of mass fractions of raw materials used in examples 1 to 8

Components	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6	Example 7	Fruit 8
									Active ingredient	1	5	10	40	50	30	25	20
Adhesive agent	1	1	1	4	5	3	2.5	2
									Dispersing agent	0.1	0.5	1	4	5	3	2.5	2
Wetting agent	0.1	0.5	1	4	5	3	2.5	2
									Disintegrating agent	1	1	1	4	5	3	2.5	2
Water (W)	0.1	1	2	8	10	6	5	4
									Stable, sucking and moistening	0.1	0.5	1	4	5	3	2.5	2
Solid inert carrier	96.6	90.5	83	32	15	49	57.5	66

Table 2 tabulation of weight ratio of each material in active ingredients in examples 1 to 8

Active substance	Chlorantraniliprole	Phoxim	Tea seed cake
				Example 1	1	0.01	98.89
Example 2	1	0.03	98.97
				Example 3	1	0.1	98.9
Example 4	1	5	94
				Example 5	1	10	89
Example 6	1	20	79
				Example 7	1	30	69
Example 8	1	40	59

Table 3 list of specific substances used as adjuvants in examples 1 to 8

Table 4 list of field control effects of pesticide composition granules prepared in examples 1 to 8 on spodoptera litura in cotton

Time of day	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6	Example 7	Example 8
									1 day	79.5	81.8	83.4	85.3	84.6	84.3	84.6	85.0
3 days	89.9	91.2	92.6	95.7	95.6	94.8	95.1	95.6
									7 days	80.7	82.6	85.7	86.4	86.3	86.1	87.2	86.9

Table 5 list of the field control effects of the pesticide composition granules prepared in examples 1 to 8 on ampullaria gigas in rice

Time of day	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6	Example 7	Example 8
									1 day	75.6	77.9	81.5	82.3	81.4	82.8	83.4	83.3
3 days	88.4	89.5	91.8	91.6	92.3	92.4	92.7	93.5
									7 days	78.6	79.4	83.5	85.3	83.7	84.7	85.6	84.6

Table 6 list of field control effects of the granular pesticide compositions prepared in examples 1 to 8 on wireworms in wheat

Time of day	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6	Example 7	Example 8
									1 day	78.2	78.6	80.2	81.1	81.7	82.3	82.8	83.0
3 days	90.3	90.5	91.7	92.3	92.7	93.5	94.0	94.2
									7 days	82.6	83.4	84.3	85.6	84.9	86.0	86.3	85.4

Table 7 table of the field control effects of the pesticide composition granules prepared in examples 1 to 8 on camellia sinensis

Time of day	Example 1	Example 2	Example 3	Example 4	Example 5	Example 6	Example 7	Example 8
									1 day	77.6	78.3	81.6	82.9	83.2	81.8	82.5	83.0
3 days	89.5	90.6	91.4	92.6	92.4	93.4	93.7	93.1
									7 days	82.3	83.2	83.4	86.4	85.4	86.9	87.2	85.8

Comparative example 1

The dosage and the use of the auxiliary agent are the same as those of the example 1, the composition of the comparative example is prepared into granules for controlling the pests of the crop fields, and the use condition is the same as that of the example 1; the use cases comprise the dosage and the applied pests to which the crops are directed; specific data for pest control are detailed in table 8.

Table 8 control of the pesticide composition of comparative example 1 against field pests

Species of pest	1 day	3 days	7 days
				Cotton field prodenia litura	7.8	6.2	3.1
Pomacea canaliculata in rice	6.7	5.6	4.5
				Golden needle worm in wheat	8.1	6.5	4.0
Elephant of camellia in tea	8.7	5.7	3.8

Comparative example 2

The chlorantraniliprole and phoxim are used as active components, the dosage and the use of the auxiliary agent are the same as those in example 3, the composition of the comparative example is prepared into granules for controlling pests in crop fields, and the use condition is the same as that in example 3; the use cases comprise the dosage and the applied pests to which the crops are directed; specific data for pest control are detailed in table 9.

TABLE 9 control of pests in the field by the pesticidal composition of comparative example 2

Species of pest	1 day	3 days	7 days
				Cotton field prodenia litura	8.5	6.4	3.1
Pomacea canaliculata in rice	6.8	5.3	4.3
				Golden needle worm in wheat	8.9	7.2	4.7
Elephant of camellia in tea	9.2	6.8	4.8

Comparative example 3

The chlorantraniliprole and the tea seed cake are used as active components, the dosage and the use of the auxiliary agent are the same as those in example 5, and the composition of the comparative example is prepared into granules for controlling pests in crop fields, and the use condition is the same as that in example 5; the use cases comprise the dosage and the applied pests to which the crops are directed; specific data for pest control are detailed in table 10.

TABLE 10 control of field pests with the pesticidal composition of comparative example 3

Species of pest	1 day	3 days	7 days
				Cotton field prodenia litura	7.4	5.6	3.8
Pomacea canaliculata in rice	6.9	6.5	4.1
				Golden needle worm in wheat	8.0	6.6	3.8
Elephant of camellia in tea	8.1	5.8	4.9

Comparative example 4

The phoxim is used as an active component, the dosage and the use of the auxiliary agent are the same as those in example 6, the composition of the comparative example is prepared into granules for controlling the pests in the crop fields, and the use condition is the same as that in example 6; the use cases comprise the dosage and the applied pests to which the crops are directed; specific data for pest control are shown in Table 11.

TABLE 11 control of pests in fields by the pesticidal composition of comparative example 4

Species of pest	1 day	3 days	7 days
				Cotton field prodenia litura	27.5	22.8	19.5
Pomacea canaliculata in rice	26.8	21.7	18.5
				Golden needle worm in wheat	28.1	23.4	21.5
Elephant of camellia in tea	26.4	24.9	21.8

Comparative example 5

The phoxim and the tea seed cake are used as active components, the dosage and the use of the auxiliary agent are the same as those in example 7, the composition of the comparative example is prepared into granules for controlling the pests in the crop fields, and the use condition is the same as that in example 7; the use cases comprise the dosage and the applied pests to which the crops are directed; specific data for pest control are detailed in table 12.

TABLE 12 control of field pests with the pesticidal composition of comparative example 5

Species of pest	1 day	3 days	7 days
				Cotton field prodenia litura	35.6	33.5	29.8
Pomacea canaliculata in rice	36.9	33.6	31.2
				Golden needle worm in wheat	38.4	34.1	31.6
Elephant of camellia in tea	36.7	34.9	32.5

Comparative example 6

The tea seed cake is used as an active component, the dosage and the use of the auxiliary agent are the same as those in example 8, and the composition of the comparative example is prepared into granules for controlling pests in crop fields, and the use condition is the same as that in example 8; the use cases comprise the dosage and the applied pests to which the crops are directed; specific data for pest control are detailed in table 13.

TABLE 13 control of pests in fields by the pesticidal composition of comparative example 6

Species of pest	1 day	3 days	7 days
				Cotton field prodenia litura	4.4	3.6	3.8
Pomacea canaliculata in rice	3.9	5.5	4.1
				Golden needle worm in wheat	3.5	3.6	3.8
Elephant of camellia in tea	4.1	3.8	3.9

Examples and comparative examplesWherein the chlorantraniliprole is also called chlorantraniliprole, the chemical name is 3-bromo-4 ' -chloro-1- (3-chloro-2-pyridyl) -2' -methyl-6 ' - (methylcarbamoyl) pyrazole-5-formanilide, the name of English is chroraraniprole, the molecular formula is C₁₈H₁₄BrCl₂N₅O₂Relative molecular mass 483.2, CAS No.: 500008-45-7, the structural formula is shown as follows:

phoxim in the examples and comparative examples is the compound O, O-diethyl-O- α -cyanobenzylideneaminophosphorothioate, having the trade name Phoxim and the formula C₁₂H₁₅N₂O₃PS, relative molecular weight 298.2979, CAS number 14816-18-3, structural formula shown below.

According to the invention, the chlorantraniliprole, the phoxim and the tea seed cake are mixed to prepare the synergistic pesticide composition, and the pesticide mixture has good control effects on the camellias elephant in tea trees, the pomacea canaliculata in rice fields, the wireworm in wheat fields and the prodenia litura in cotton fields, is quick in response time and obvious in control as can be seen from tables 4 to 13 of field pesticide effect data statistics; and the comparison of comparative examples 1 to 6 shows that the chlorantraniliprole, the phoxim and the tea seed cake have obvious synergistic interaction, the dosage of the chemical insecticide is obviously reduced, the generation of drug resistance of pests is delayed, the granules are prepared, so that the drug effect of active ingredients can be better exerted, the stability of the granules and the control effect on the pests are obviously improved; in addition, the tea seed cake is residue left after oil extraction of tea seeds, contains flavonol glycoside and tea saponin, has certain fertilizer effect and good insecticidal and bacteriostatic effects.

Claims

1. A synergistic pesticidal composition characterized by:

comprises active components and auxiliary agents; wherein the active components comprise chlorantraniliprole, phoxim and tea seed cake.

2. A synergistic pesticidal composition as claimed in claim 1 wherein: the mass ratio of the chlorantraniliprole to the phoxim to the tea seed cake is as follows: 1: (0.01-40): (98.99-59).

3. A synergistic pesticidal composition as claimed in claim 1 wherein: the mass ratio of the chlorantraniliprole to the phoxim to the tea seed cake is 1: (0.03-30): (98.97-69).

4. A synergistic pesticidal composition as claimed in claim 1 wherein: the weight ratio of the chlorantraniliprole to the phoxim to the tea seed cake is 1: (0.1-10): (98.9-89).

5. A synergistic pesticidal composition as claimed in any one of claims 1 to 4, wherein:

the auxiliary agent comprises: binder, dispersant, wetting agent, disintegrant, water, stabilizer, adsorbent, lubricant and solid inert carrier;

the composition comprises the following components in percentage by mass:

the rest auxiliary agent is a solid inert carrier.

6. A process for the preparation of a synergistic pesticidal composition as claimed in claim 5, characterized in that:

the method comprises the following steps:

7. Use of the granules prepared according to claim 6 for controlling crop pests.

8. The use of claim 7, wherein:

the pest comprises one of Spodoptera litura, Pomacea canaliculata, wireworm, camellias, grub, cutworm, Gryllotalpa, golden yellow mealworm, root maggot, slug and snail.

9. The use of claim 7, wherein: the crop comprises one of lotus root, water bamboo, tea tree, rice, wheat, corn, fruit tree, cotton and cruciferous vegetable.