CN111388603A - New application of herba Dendrobii in preparing product for preventing, treating and preventing and treating vascular calcification diseases - Google Patents
New application of herba Dendrobii in preparing product for preventing, treating and preventing and treating vascular calcification diseases Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention relates to the technical field of medicines and special medical foods, in particular to a new application of dendrobium in preparing products for preventing, treating and preventing and treating vascular calcification diseases, which comprises the application of dendrobium in preparing products for preventing, treating and preventing and treating vascular calcification diseases according to the dosage proportion.
Description
Technical Field
The invention relates to a new application of dendrobium, in particular to a new application of dendrobium in preparing products for preventing, treating and preventing and treating vascular calcification diseases, and belongs to the technical field of medicines and special medical foods.
Background
Vascular calcification is common in aging, atherosclerosis, hypertension, diabetes, dyslipidemia, valvular heart disease, chronic kidney disease and other people, and is caused by ectopic deposition of hydroxyapatite on the vascular wall; vascular calcification increases the risk of heart disease, stroke, atherosclerotic plaque rupture, and is an important risk factor for increasing morbidity and mortality of cardiovascular disease; therefore, vascular calcification is receiving increasing attention worldwide. Initially, researchers thought that vascular calcification was the result of a passive degenerative process, indicative of vascular aging; however, more and more research has shown that vascular calcification is an active process initiated and regulated by a variety of molecular signaling pathways, with a high degree of similarity to bone formation; the main theories for explaining the mechanism of the vascular calcification molecules at present are the osteogenic differentiation of vascular smooth muscle cells, the deletion of calcification inhibitors, abnormal calcium and phosphate homeostasis, oxidative stress, inflammation, apoptosis, autophagy, matrix remodeling, miRNA regulation and the like.
However, the traditional medicine has poor effect in the treatment aspect of effectively preventing or reversing vascular calcification, the dendrobium is a plant in the dendrobium genus of orchidaceae, and more varieties of dendrobium officinale, dendrobium huoshanense, dendrobium nobile, dendrobium fimbriatum and the like are common in medicinal plants and are usually used as nourishing medicinal herbs and health foods, and the Chinese pharmacopoeia records that the main functional indications are as follows: benefiting stomach, promoting fluid production, nourishing yin and clearing heat; can be used for treating fever, body fluid consumption, xerostomia, polydipsia, stomach yin deficiency, anorexia, retching, asthenia heat after illness, hyperactivity of fire due to yin deficiency, bone steaming, fatigue, dim eyesight, flaccidity of bones and muscles, and herba Dendrobii is not used in product for preventing and treating vascular calcification.
Disclosure of Invention
The invention aims to solve the problems and provide a new application of dendrobium in preparing products for preventing vascular calcification diseases, the dendrobium is applied in the products for preventing the vascular calcification diseases according to the dosage proportion, experiments prove that the dendrobium can obviously reduce the vascular calcification area and inhibit the occurrence and development of the vascular calcification, the dendrobium has obvious effect of inhibiting the vascular calcification, obvious effect and extremely high safety, so the dendrobium has wide application prospect in the prevention and treatment of the vascular calcification, large-scale artificial planting is realized, the dendrobium can be one or more of dendrobium huoshanense, dendrobium candidum, dendrobium nobile, dendrobium chrysanthum nobile lindl, dendrobium fimbriatum hance, dendrobium chrysanthum kom, dendrobium chrysotou and dendrobium nobile belonging to the same genus, the dendrobium nobile can be obtained from a variety of sources, the price is relatively low, and the medicine burden of patients can be reduced.
The new application of the dendrobium according to the first aspect of the invention in preparing the product for preventing the vascular calcification disease comprises the application of the dendrobium in preparing the product for preventing the vascular calcification disease according to the dosage ratio.
Preferably, in order to make the raw materials more extensive, the dendrobium stem is one or more of dendrobium huoshanense, dendrobium officinale, dendrobium nobile, dendrobium fimbriatum, dendrobium chrysotoxum and dendrobium officinal belonging to the same genus.
Preferably, in order to facilitate the application of the dendrobium to the drugs for inhibiting and treating vascular calcification, the product comprises one or more of drugs and special medical foods.
The new application of the dendrobium according to the second aspect of the invention in preparing the product for treating the vascular calcification disease comprises the application of the dendrobium in preparing the product for treating the vascular calcification disease according to the dosage ratio.
Preferably, in order to make the raw materials more extensive, the dendrobium stem is one or more of dendrobium huoshanense, dendrobium officinale, dendrobium nobile, dendrobium fimbriatum, dendrobium chrysotoxum and dendrobium officinal belonging to the same genus.
Preferably, in order to facilitate the application of the dendrobium to the drugs for inhibiting and treating vascular calcification, the product comprises one or more of drugs and special medical foods.
The invention has the beneficial effects that: experiments prove that the dendrobium can obviously reduce the area of vascular calcification and inhibit the occurrence and development of vascular calcification, has obvious effect of inhibiting vascular calcification, obvious effect and high safety, has wide application prospect in the prevention and treatment of vascular calcification, realizes large-scale artificial planting, can be one or more of dendrobium huoshanense, dendrobium candidum, dendrobium nobile lindl, dendrobium fimbriatum, dendrobium chrysotoxum and dendrobium nobile belonging to the same genus, has rich sources and relatively low price, and can reduce the medicine burden of patients.
Drawings
FIG. 1 is a graph showing the inhibition of vascular calcification in the root of aorta in L D L R-/-mice (panel A is the result of alizarin red S staining in L D L R-/-mouse aorta root section; panel B is the statistical result of alizarin red S staining area ratio; in the graph, P is less than 0.01, and the significance is shown compared with Ctrl group);
FIG. 2 is a graph showing that Dendrobium officinale inhibits the development of L D L R-/-mouse aortic root vascular calcification (panel A is a graph showing the result of alizarin red S staining of L D L R-/-mouse aortic root section; panel B is a statistical result showing the ratio of alizarin red S staining area; in the graph, P is less than 0.05, and significance is shown compared with Ctrl group).
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The new application of the dendrobium according to the first aspect of the invention in preparing the product for preventing the vascular calcification disease comprises the application of the dendrobium in preparing the product for preventing the vascular calcification disease according to the dosage ratio.
As a technical optimization scheme of the invention, the dendrobium can be one or more of dendrobium huoshanense, dendrobium officinale, dendrobium nobile, dendrobium stem of fimbriatum, dendrobium chrysotoxum and dendrobium officinal belonging to the same genus.
As a technical optimization scheme of the invention, in order to facilitate the application of the dendrobium to the drugs for inhibiting and treating vascular calcification, the product comprises one or more of drugs and special medical foods.
The new application of the dendrobium according to the second aspect of the invention in preparing the product for treating the vascular calcification disease comprises the application of the dendrobium in preparing the product for treating the vascular calcification disease according to the dosage ratio.
As a technical optimization scheme of the invention, the dendrobium can be one or more of dendrobium huoshanense, dendrobium officinale, dendrobium nobile, dendrobium stem of fimbriatum, dendrobium chrysotoxum and dendrobium officinal belonging to the same genus.
As a technical optimization scheme of the invention, in order to facilitate the application of the dendrobium to the drugs for inhibiting and treating vascular calcification, the product comprises one or more of drugs and special medical foods.
The new application of the dendrobium nobile in preparing the product for preventing and treating the vascular calcification diseases comprises the application of the dendrobium nobile in preparing the product for preventing and treating the vascular calcification diseases according to the dosage proportion.
As a technical optimization scheme of the invention, the dendrobium can be one or more of dendrobium huoshanense, dendrobium officinale, dendrobium nobile, dendrobium stem of fimbriatum, dendrobium chrysotoxum and dendrobium officinal belonging to the same genus.
As a technical optimization scheme of the invention, in order to facilitate the application of the dendrobium to the drugs for inhibiting and treating vascular calcification, the product comprises one or more of drugs and special medical foods
In use, female L D L R-/-mice at 6-8 weeks of age were purchased from Nanjing university model animal institute at 20-25g, and data presented as mean + -SEM were generated from at least three independent experiments using Dunnett's multiple comparison test and analysis of variance, where P <0.05 is statistically significant.
Example 1 Dendrobium huoshanense inhibits vascular calcification in L D L R knockout mice
1, L D L R-/-preparation of mouse vascular calcification model
The method comprises the following steps of carrying out adaptive feeding on L D L R-/-mice with the age of about 6 weeks and the weight of 17 males, wherein the mice weigh about 22g and are randomly divided into 2 groups after 1 week, carrying out control group (Ctrl group), feeding 8 mice with high-fat food, carrying out dendrobium huoshanense treatment group (DH group), carrying out 9 mice, feeding all the mice with freely-fed drinking water after crushing fresh dendrobium huoshanense with the weight of 5g/kg mice per day and uniformly mixing the crushed fresh dendrobium huoshanense with the high-fat food according to Chinese pharmacopoeia (first part), feeding the mice with the fresh dendrobium huoshanense, feeding the mice with the water, carrying out euthanasia after 18 weeks, and carrying out related research on related tissues and organs such as aorta and the like.
2. Alizarin red S staining of aortic root
After trimming the aortic root, the aorta was fixed in 4% paraformaldehyde general tissue fixative for 48h and then dehydrated in 30% sucrose solution for 24 h. The dehydrated tissue was embedded in OCT, and sectioned with a microtome at a thickness of 5 μm. The frozen section of the aortic root is dried at room temperature, soaked in PBS for 5min, stained with 1% alizarin red S staining solution for 30min, rinsed twice with acidic PBS (pH 4.1-4.3) to remove loose color, observed under a microscope for photographing, and the calcium deposition condition in the sample is statistically analyzed.
3. Experimental results;
the results show (figure 1) that the calcified area of the aortic root in Ctrl group is 1.34%, while the calcified area of the aortic root in DH group is 0.88%, which is reduced by about 34%, which shows that dendrobium huoshanense has very significant inhibition effect on the development of L D L R-/-mouse vascular calcification.
Example 2 Dendrobium officinale Kimura et Migo inhibits vascular calcification in L D L R knockout mice
1, L D L R-/-preparation of mouse vascular calcification model
L D L R-/-mice with the age of about 6 weeks, which weigh about 22g, are adaptively fed for 1 week and are randomly divided into 2 groups, a control group (Ctrl group) comprises 10 mice fed with high-fat food, and a dendrobium officinale treatment group (DO group) comprises 10 mice, according to the recommendation of Chinese pharmacopoeia (first division), the dosage of fresh dendrobium officinale products is 10 times larger, namely, fresh dendrobium officinale products with the weight of 5g/kg of the mice per day are crushed and uniformly mixed with high-fat food to feed the fresh dendrobium officinale, all the mice freely eat water, the mice are fed with the water, the mice are euthanized after 18 weeks, and relevant tissues and organs such as aorta and the like are taken for relevant research.
2. Alizarin red S staining of aortic root, same as example 1
3. Experimental results;
we stained aortic root sections of mice with alizarin red S staining solution. The results show (fig. 2) that the area of calcified root of aorta in Ctrl group is 1.21%, while the area of calcified root of aorta in DO group is 1.07%, and dendrobium officinale has significant effect in inhibiting the development of calcification in mice.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (9)
1. A new application of dendrobium nobile in preventing vascular calcification disease products is characterized in that: the stone is applied according to the dosage proportion in the preparation of products for preventing vascular calcification diseases.
2. The new application of the dendrobium nobile lindl in the product for preventing vascular calcification diseases according to claim 1 is characterized in that: the herba Dendrobii is one or more of herba Dendrobii, and caulis drumstick and its medicinal herba Dendrobii of the same genus.
3. The new application of the dendrobium nobile lindl in the product for preventing vascular calcification diseases according to claim 2 is characterized in that: the product comprises one or more of medicines and special medical foods.
4. A new application of dendrobium nobile in products for treating vascular calcification diseases is characterized in that: the dendrobium is applied to the preparation of products for treating vascular calcification diseases according to the dosage ratio.
5. The new application of the dendrobium nobile lindl in the product for treating vascular calcification diseases according to claim 4 is characterized in that: the herba Dendrobii is one or more of herba Dendrobii, and caulis drumstick and its medicinal herba Dendrobii of the same genus.
6. The new application of the dendrobium nobile lindl in the product for treating vascular calcification diseases according to the claim 5 is characterized in that: the product comprises one or more of medicines and special medical foods.
7. A new application of dendrobium nobile in products for preventing and treating vascular calcification diseases is characterized in that: the dendrobium is applied to the preparation of products for preventing and treating vascular calcification diseases according to the dosage proportion.
8. The new application of the dendrobium nobile lindl in the products for preventing and treating the vascular calcification diseases according to the claim 7 is characterized in that: the herba Dendrobii is one or more of herba Dendrobii, and caulis drumstick and its medicinal herba Dendrobii of the same genus.
9. The new application of the dendrobium nobile lindl in the products for preventing and treating the vascular calcification diseases according to the claim 8 is characterized in that: the product comprises one or more of medicines and special medical foods.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114917210A (en) * | 2022-06-10 | 2022-08-19 | 合肥工业大学 | Application of dendrophenol in preparation of medicines for preventing and treating vascular calcification |
| CN115068558A (en) * | 2022-06-08 | 2022-09-20 | 滨州医学院 | Application of dendrobium huoshanense extract in preparation of medicine for treating and/or preventing lower limb arteriosclerotic occlusion |
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| CN104352805A (en) * | 2014-11-13 | 2015-02-18 | 宋爱民 | Traditional Chinese medicine paste for treating calcification of paxwax |
| CN108888713A (en) * | 2018-05-16 | 2018-11-27 | 遵义医学院 | Application of the HERBA DENDROBII total alkali in preparation atherosclerosis drug |
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