CN103330175B - Seasoning made of natural plant compositions and preparation method thereof - Google Patents
Seasoning made of natural plant compositions and preparation method thereof Download PDFInfo
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- CN103330175B CN103330175B CN201310224909.0A CN201310224909A CN103330175B CN 103330175 B CN103330175 B CN 103330175B CN 201310224909 A CN201310224909 A CN 201310224909A CN 103330175 B CN103330175 B CN 103330175B
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Abstract
The invention discloses a seasoning made of natural plant compositions and a preparation method thereof. The seasoning comprises the following components in parts by weight: 25-30 parts of moringa oleifera, 20-35 parts of cedrela sinensis, 3-5 parts of amomum villosum lour, 5-8 parts of madarin orange peel, 5-8 parts of pogostemon cablin and 3-5 parts of syzygium aromaticum. The seasoning disclosed by the invention has the flavor similar to the traditional seasoning, and simultaneously also has the functions of reducing nausea and vomiting and improving appetite.
Description
Technical field
The present invention relates to a kind of natural plant composition, specifically, relate to a kind of natural plant composition flavouring.
Background technology
N and V and apocleisis are present in the therapeutic process of various diseases or disease, n and V and the poor appetite of the healthy and rehabilitation of common impact comprise: the vomiting of pregnancy, various Post operation vomiting, cancer chemotherapy vomiting, disease apocleisis and children anorexia.Feel sick for epigastric discomfort and the urgent sensation for telling, can with the symptom of vagal excitation, as ochrodermia, perspiration, salivation, blood pressure reduction and bradycardia etc., normal is the prelude vomitted.General feel sick after vomit thereupon, but also only can have and to feel sick and without vomiting, or only have vomiting and without feeling sick.Vomiting forces the content of stomach or part small intestine through oesophagus, oral cavity and the performance excreted by the strong contraction of stomach.Its process can be divided into 3 stages, namely feels sick, retches and vomiting.When feeling sick, epigastric is loosened and the of short duration contraction in stomach hole portion; Stomach hole portion contracts last during vomiting, opening gastric cardia, contraction of abdominal muscle, abdominal pressure increases, and forces gastric content rapidly and fiercely from gastric reflux, through oesophagus, oral cavity and excreting.
Traditional Chinese Medicine theory thinks that the vomiting of pregnancy refers to pregnancy duration, the gas superinverse of melancholy chong channel, stomach Qi rising and cause n and V, dizzy apocleisis, even eat namely tell, spitting blood, cholemesia juice, the pregnant rear vomiting of severe patient is violent, vomit bitter water, very then vomiting band blood sample thing, One's spirits are drooping, body is become thin, eye socket caves in, one's eyes are lustreless, limbs fatigue, generates heat thirsty, oliguria constipation, words are dry, and severe patient can occur that the danger such as jaundice, renal shutdown, in a certain state of delirium, delirium, stupor is waited, and tongue is red, thin and the dry sliding light stripping of tongue, thready,rolling and rapid pulse is unable.Modern medicine related data display about 60% women menelipsis within about 6 weeks, occur chilly, dizziness, weak, drowsiness, lose the appetite, the sour thing of eating or detest greasy, nauseating, morning and play the series of symptoms such as vomiting, be called morning sickness.How within about 12 weeks, to die away in menelipsis.The violent n and V of pregnant early stage appearance, water inlet of can not taking food, even spitting blood and bile, can there is jaundice, renal shutdown, in a certain state of delirium, delirium, stupor in severe patient, also have dehydration in various degree, even low blood pressure and electrolyte disturbance, blood CO
2cP declines, and urine ketoboidies is positive, and claim hyperemesis gravidarum, incidence is 0.35% ~ 0.47%.The visible vomiting of pregnancy can affect the growth of fetus and the healthy of pregnant woman.
Postoperative pain, nausea and vomiting are modal symptom complexs.Along with the clinical of PCA's technology generally uses, the treatment situation of postoperative pain has had obvious improvement.And the incidence of Postoperative Nausea and Vomiting does not significantly decrease over nearly more than 10 years.Although nausea and vomiting is body is the normal physiological reflection alleviating alimentary canal sustain damage, because it makes people have insufferable subjective sensation, and serious complication can be caused.Therefore, the problem how reducing Postoperative Nausea and Vomiting generation is the problem that anesthetist pays close attention to all the time.Postoperative Nausea and Vomiting incidence does not vary widely in recent years, be between 20% one 30% according to anesthesia and the unusual of operation kind, and the incidence of postoperative nausea and vomiting can up to 70% when operation on the middle ear and Tonsillectomy etc. are performed the operation.Except subjective sense of discomfort, after n and V, also can cause certain death rate because of complication such as de-water and rock-soil coupling and aspiration pneumonias.During hyperemesis, also can there are some abdominal pressures and increase surgical complications such as causing wound dehiscence.Postoperative Nausea and Vomiting not only causes the recovery time of patient to extend, and reduces the turnover rate of the room sick bed that regains one's consciousness after being anaesthetized, and increases because vomitting the nurse fees caused, and also makes day surgery expense increase thereupon.
Cancer has become a global problem.According to statistics, the annual whole world has 1,200 ten thousand people to be newly diagnosed as cancer at present, and 7,600,000 people die from cancer.And the incidence of disease of cancer is also in continuous increase, if held fire, will there be 2,600 ten thousand new cases in the expectation the year two thousand thirty whole world.Chemotherapy is one of the most frequently used method of current oncotherapy, has the tumor patient of 70% once to accept chemotherapy.The Nausea and vomiting that during malignant tumor chemotherapy, gastrointestinal side effect causes is the most common, accounts for greatly chemotherapy patients's 75%, and these bad reactions reduce the quality of life of patient, limits drug treatment and dosage.Chemotherapeutics also damages human normal tissue cell at killing tumor cell simultaneously simultaneously, result in the toxic and side effects such as digestive tract reaction, bone marrow suppression, kidney damage, and wherein patient Chang Yin vomiting reaction produces frightened to chemotherapy, so that TD.The visible cancer patient of nearly 53% is subject to the harm of n and V.To emesis of chemotherapy research, people find that 5-HT passes through 5-HT
3acceptor works in periphery and maincenter, research and development 5-HT
3receptor antagonist, is widely used in clinical, has obvious curative effect to acute vomiting.But receptor antagonist is invalid to vomitting in advance, to Delayed emesis weak curative effect.Find that Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 passes through NK afterwards
1acceptor works.NK
1receptor antagonist has antiemetic effect widely, and for acute vomiting and Delayed emesis all effective.But to NK
1receptor antagonist human body pharmacological action, also need further research to vomitting the whether problem such as effective in cure and toxic and side effect in advance.No matter 5-HT
3receptor antagonist or NK
1receptor antagonist does not all avoid chemotherapeutics to gastral damage.Thus strengthen chemotherapeutics attack tumour cell specificity or protection gastrointestinal mucosa especially stomach and intestine chromaffin cell be also the research direction avoiding emesis of chemotherapy to produce.
Apocleisis refers to because appetite lowers or disappearance, causes food-intake to decline and body weight reduction.Cancer cachexia is normally defined Body weight loss (in 2 months, insentience Body weight loss reaches in 2% or 6 months and reaches 5%), apocleisis, visual analogue scales (visual analogue scale, VAS) >3 or oral feeding and takes in obstacle (be less than normal 75% or <20kcal/kg).
Apocleisis is also common disease in children, frequently-occurring disease in addition, seriously hinders the growing of children, often causes the disease such as anaemia, the disorders of digestion to occur, thus pay attention to by the world of medicine.
Through the research of nearly decades, for the treatment of vomiting, especially the vomiting that causes of chemotherapy, has achieved very much progress, but still could not reach and accomplish antiemetic completely, this prompting is except the neurotransmitters such as 5 one HT known today and Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, still have the participation of other neurotransmitters, and these neurotransmitters can be nauseant, also can be suppress vomiting, perhaps normal human, inherently there is antiemetic and cause the balance of telling.From biological evolution angle, vomit a kind of self-protective mechanism as human body, be difficult to suppress it completely; and can only alleviate; because its mechanism may involve several or tens of kinds of mechanism (approach), an approach is suppressed, then other approach will be correspondingly compensatory.So, although treatment is told in current causing very much progress, also have too many tera incognita.
Visible n and V and poor appetite are only considered that a drug therapy is incomplete, also will take into account feed, so just be conducive to the rehabilitation of health while medicine preventing or arresting vomiting, so researching and developing out the little food flavor of toxic and side effect is a good trial.Because the use crowd of this flavouring is a special colony, forms raw-material selection and will consider several aspect: the first, edible security, have at home or abroad the long period use history and without any the record of toxic and side effect; The second, raw material will containing abundant nutrient chemistry composition; Three, Chinese Traditional Medicine document records single material or composition to alleviating n and V and poor appetite has good result for the treatment of; Four, good seasoning effect is had.Require that we are through many-sided abundant documents synthetical analysis and chemistry, pharmacology test, have selected Moringa, Chinese toon, fructus amomi, citrus chachiensis hortorum, Pogostemon cablin and cloves as the raw material of research and development product according to these.
Moringa is Moringaceae Moringa plant Moringa oleifera, is a kind of tropical plants having unique economic to be worth.Undergraduate course only has a genus, totally 14 kinds.Wherein M.stenopetala is distributed in that Ethiopia and Kenya are northern, M.peregrina is distributed in the Sudan, Egypt and the Arabia Peninsula, M.ovalifolia and is distributed in Angola and Namibia, M.oleifera are distributed in Himalaya region, north India Asia, these 4 kinds oneself have cultivation.Our investigation and application be this kind of Moringa M.oleifera, blade and the fruit of Moringa are rich in several mineral materials, vitamin and health care and medicinal chemistry composition, as vegetables and food, extra-nutrition and Dietotherapy health function can be had, also may be used for preventing and treating some diseases.Folk tradition is thought that Moringa has and is brought down a fever, anti-inflammatory, row's stone, diuresis, step-down, pain relieving, cardiac stimulant, urges the functions such as wish.India and African country are usually used in the various diseases such as treatment diabetes, hypertension, cardiovascular disease, obesity, skin disease, eye illness, hypoimmunity, scurvy, anaemia, arthritis, rheumatism, digestive system tumor.Visible Moringa abroad multiple country and nationality has had long safe edible history, and containing abundant nutritional labeling even medicinal ingredient, there are six large nutrients five of needed by human body, i.e. protein, fat, carbohydrate, vitamin and mineral matter.
Chinese toon Toona Sinensis (A.Juss.) Roem is Meliaceae Cedrela deciduous tree.The skin (the bark of the root or stem of the tree of heaven) of Chinese toon, myron (Chinese toona juice), fruit (Chinese toona fruit) all can be done medicinal.The leaf of Chinese toon leaf system Chinese toon, spring gathers, many using fresh herbs.Taste is pungent, bitter, and property is put down, and returns spleen, stomach warp.Have and eliminate summer heat and remove dampness, the effect of removing toxic substances desinsection.Cure mainly in summer-heat and damp wound, n and V, lose the appetite, have loose bowels, dysentery, swollen ulcer drug, scabies, tinea capitis etc.For even numbers winglike compound leaf, alternate, long 25 ~ 50cm, has special odor; Containing 10 ~ 22, leaflet, to raw or near to life, there is short handle; Long Circle to draping over one's shoulders needle-like Long Circle, long 8 ~ 15cm, base portion deflection, circle or circle wedge shape, tip point, full edge or have sparse sawtooth, above bottle green, without hair, lower complexion is light, and have long bundle hair between vein or arteries and veins, petiole is red, base portion hypertrophy.In China many places, Chinese toon tender leaf is used as vegetables.
Research shows, Chinese Toon Leaves, containing carrotene and Cobastab, c, finds again that chemical composition mainly contains flavonoids, volatile oil, nutritional labeling etc. in the recent period.In Chinese Toon Leaves, the content of general flavone, can reach 4.46%.Comprising: Quercetin, kaempferol and quercitrin rope glycosides, kaempferol-O-glycoside etc.Volatile oil in Chinese Toon Leaves is monoterpene, sequiterpene and sesquiterpenoid compounds mainly.Comprise: cloves alkene, FARNESOL, camphor, borneol, 3,4 one dimethyl decane, α-humulene, Bronyl acetate, cedrol etc.The nutritional labeling of Chinese Toon Leaves mainly contains protein, vitamin C, carrotene and calcareous, polysaccharide etc.In Chinese Toon Leaves, the content of protein is up to 21.20% ~ 22.27%, the amino acid of constitutive protein matter, except containing except 7 kinds of essential amino acids (lysine, leucine, isoleucine, threonine, phenylalanine, valine, methionine), also have some nonessential amino acid (as cystine, histidine, arginine, tyrosine, glycine).In Chinese Toon Leaves, ascorbic content reaches 1010 ~ 1050mg/kg, higher than part Foods.
Fructus Amomi, citrus chachiensis hortorum, Pogostemon cablin and cloves are famous Chinese medicine in addition, are the integration of drinking and medicinal herbs kinds that Ministry of Health of the People's Republic of China specifies.
Fructus amomi is the ripening fruits of zingiberaceous plant amomum viosum Amomum villosum Lour., green shell sand A.villosum Lour.var.xanthioides T.L.Wu et Senjen or SEMEN AMOMI LONGILIGULA A.longiligulare T.L.Wu.Another name fructus amomi, Fructus Amomi, contracting fructus amomi.Fructus amomi is the distinctive Plants of Perenniporia martius, and its fruit is the medicinal material of armaticity simply that the traditional Chinese medical science is commonly used.Commodity fructus amomi is remarkable with Fructus Amomi comparitive study, and quality is also relatively good, and higher reputation is enjoyed in international medicinal material market.Fructus amomi is food and medicine, and taste is pungent, warm in nature, has and has a strong smell, except raw meat, effect such as increasing taste, flavouring etc., also for the seasoning of food.Have tonifying lung to be amusing, nourishing the stomach kidney-nourishing, reason vigour, dispelling stagnant Qi, dispelling cold fluid-retention and abdominal distension, promoting the circulation of qi wide in, the effect of stomach strengthening and digestion promoting, the medicinal efficacy such as also there is stomach invigorating, help digestion, also for the seasoning, fresh-keeping of food.Fructus amomi fresh goods is longer than dampness elimination promoting the circulation of qi, is amusing and stomach, is usually used in treating the abdominal distention of the taste stagnation of the circulation of vital energys, indigestion and loss of appetite, vomiting etc.After salt system, the property of dampness elimination slightly subtracts, temperature and not hot-tempered, and the antiabortive effect of sending down abnormally ascending strengthens, and can priming descending, be usually used in treatment fetal irritability.Fructus Amomi seed contains volatile oil more than 3%.Main body of oil is the compounds such as bornyl acetate (bornyl acetate) borneol, camphor, linalool, nerolidol, catechin, brown lemon alkene, amphene.Another also containing flavones ingredient.Shell sand (contracting sand) benevolence seed is containing volatile oil about 1.7% ~ 3%, and in oil, composition is roughly similar to amomum viosum seed.
Dried orange peel is the pericarp of the dry mature fruit of rutaceae orange Citrus reticulata Blanco and variety thereof.Dried orange peel original name orange peel, is used as medicine with old person for good, therefore claims dried orange peel, also claims always expensive.Have another name called " orange peel ", " PERICARPIUM CITRI RETICULATAE ", " wide skin ", " river orange peel ", main product in Chinese Guangdong newly can, the suburbs, Guangzhou, four meetings, dried orange peel Sichuan, zhejiang and other places, because place of production difference is divided into dried orange peel (real estate such as Sichuan) and citrus chachiensis hortorum (Guangdong product) 2 kinds, all large with lobe, neat, crust color depth is red, inner face is white, meat is thick, oiliness is large, the person of giving off a strong fragrance is good.Dried orange peel is pungent, warm, bitter, appetizing in tool regulating QI and lowering the adverseness, tune, eliminating dampness and eliminating phlegm merit.Strengthening the spleen and stomach, dissolving phlegm helping digestion top grade.Be used for exploding in the cooking, burn, stew, the method such as stir-fry obtains animality dish, play eliminate the unusual smell, flavouring, carry fresh, separate greasy effect.Citrus chachiensis hortorum is containing volatile oil and aurantiamarin (Hesperidin), Nobiletin (Nobiletin), inositol.Main containing citrene in volatile oil, and containing compounds such as australene, nopinene, β-phellandrene (β-Phellandrene), p-cymene, α-terpinene, linalool and bergamios.
Wrinkled giant hyssop is the herb of Labiatae herbaceos perennial Pogostemon cablin Pogostemon cablin (Blanco) Benth..Another name Pogostemon cablin, branch are fragrant, thorn stamen is careless.Mainly originate in the ground such as Chinese Guangdong, Yunnan, Sichuan.Gas perfume (or spice) is special, mildly bitter flavor, and the dense person of, fragrance many with leaf is good.Slightly warm in nature, taste are pungent, there is eliminating dampness with aromatics, the preventing or arresting vomiting that whets the appetite, deliver relieving summer-heat, regulate the flow of vital energy and in, ward off effect that is dirty, clearing damp.For turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp burnout, uncomfortable in chestly not relax, cold-dampness closes heat, illness such as stomachache vomiting and diarrhoea, nasosinusitis headache etc.Also cure mainly the disease such as flu summer-heat and damp, fever and chills, headache, chest amine ruffian is vexed, vomiting is had loose bowels, malaria, dysentery, halitosis.Wrinkled giant hyssop contains volatile oil about 1.5%, and in oil, principal component is Patchoulicalcohol (Patchouli alcohol), accounts for 52-57%.Also containing Eugenol (Eugenol), cinnaldehydrum Cinnamic aldehyde), Pogostol (Pogosto1), patchouli pyridine (Patchoulipyridine), epiguaipyridine (Epiguaipyridine), carypohyllene Caryophyllene), beta-elemene (β-Elelnene), alloaromadendrene Alloaromadendrene), patchoulene (Patchoulene), gurjunene (Gurjunene), guaiene (Guaiene), the compounds such as valencene (Valenene).
Cloves is the dry flower of plant clove of myrtaceae tree Eugenia caryophyllata Thunb..Another name is lilac, clove tree, flos caryophylli.Bud is slightly in pestle shape, and matter is solid, High oleic, and gas fragrance is strong, and taste is pungent, has numb feeling in the tongue.Mainly be distributed in the ground such as subtropical zone.Warm in nature, taste is pungent, tool warming middle energizer to descend adverse-rising qi and tonifying the kidney and support yang.For the treatment of deficiency-cold in spleen and stomach, hiccup vomiting, the few disease such as vomiting and diarrhoea, trusted subordinate's crymodynia, impotence due to deficiency of the kidney of food.Cloves bud containing volatile oil and caryophyllus oil, i.e. the compound such as Eugenol (Eugenol), acetyleugenol, B-carypohyllene (B-Caryophyllene), methyl-n-amyl ketone, gaultherolin.Containing nutritional labelings such as protein 0.3g, fatty 17.2g, carbohydrate 67.4g in every 100g cloves.
Summary of the invention
The object of the present invention is to provide and a kind ofly can alleviate n and V and the natural plant composition flavouring improving appetite and preparation method thereof.
To achieve these goals, the present invention adopts following technical scheme:
A kind of natural plant composition flavouring, is made up of the component of following ratio of weight and number:
Moringa 25-30, Chinese toon 20-25, Fructus Amomi 3-5, citrus chachiensis hortorum 5-8, Pogostemon cablin 5-8 and cloves 3-5.
The preparation method of above-mentioned natural plant composition flavouring, comprises the steps: with water cleaning, and dry, mix by weight, pulverize, sieve (80-200 order), then mix, sterilizing, and then packing gets product.
In above-mentioned preparation method, the method for described drying comprises with cold wind, steam, microwave drying or freeze drying.
In above-mentioned preparation method, the method for described sterilizing is with microwave, ultraviolet or radiation sterilization.
Compared with prior art, the present invention has following beneficial effect: the present invention relates to Moringa and Chinese toon etc. as main raw material(s) is mixed with natural plant composition flavouring.Flavouring of the present invention has the local flavor close with traditional condiment, also has the effect alleviating n and V He improve appetite simultaneously.
Detailed description of the invention
The preparation of embodiment No. 1 natural plant composition flavouring
Six kinds of raw-material ratios of weight and number are (unit 100 grams): Moringa 30, Chinese toon 20, Fructus Amomi 3, citrus chachiensis hortorum 6, Pogostemon cablin 6 and cloves 3.Cleaned by the clean running water of material, microwave drying, coordinates by weight, and pulverize, sieve (80-200 order), then mix, and uses microwave method sterilizing, and packaging gets product 6.2 kilograms.
The preparation of embodiment 2 No. two natural plant composition flavouring
Six kinds of raw-material ratios of weight and number are (unit 100 grams): Moringa 25, Chinese toon 25, Fructus Amomi 4, citrus chachiensis hortorum 5, Pogostemon cablin 8 and cloves 3.Cleaned by the clean running water of material, microwave drying, coordinates by weight, and pulverize, sieve (80-200 order), then mix, and uses microwave method sterilizing, and packaging gets product 6.2 kilograms.
The animal acute toxicity experiment of embodiment No. 3 natural plant composition flavouring.
Animal used as test and material:
NIH small white mouse 30, male and female half and half, body weight 18-20 grams, is provided by Department of Health of Guangdong Province medical experimental animal field.
A natural plant composition flavouring is prepared by the method for embodiment 1.Estimate people's consumption 10 grams/day.Be made into O.25/ml with distilled water, administration capacity 0.3ml/10 gram.
Experimental technique:
Animal is divided into 2 groups, often organizes 15.Fasting 12h before experiment, freely drinks water.Adopt gastric infusion, administration volume 0.3ml/10g, dosage is 7.5g/kg.Three administrations in one day, each minor tick 6h, integral dose is 22.5g/kg (be equivalent to 135 times of clinical plan consumption, body weight for humans presses 60kg).The abnormal response that after detailed record administration, animal occurs and death condition, Continuous Observation 7 days.The next day, weighs, and if any death, carries out pathological anatomy.Maximal tolerance dose multiple is calculated as follows: the dosage (g/kg) of dosage (g/kg)/mono-day people of maximal tolerance dose multiple=mouse.After result display mouse stomach gives a natural plant composition flavouring 22.5g/kg, the same day, Non Apparent Abnormality, observed none example death in 7 days.Mouse Weight increases normal.A natural plant composition flavouring mouse maximal tolerance dose is 22.5/kg, is equivalent to 135 times (people is by 60kg batheroom scales) of daily plan consumption.Tentatively show the security of a natural plant composition flavouring.
The acute toxicity testing of embodiment 4 No. two natural plant composition flavouring.
Animal used as test and material:
NIH small white mouse 30, male and female half and half, body weight 18-20 grams, is provided by Department of Health of Guangdong Province medical experimental animal field.
No. two natural plant composition flavouring are prepared by the method for embodiment 2.Estimate people's consumption 10 grams/day.Be made into O.25/ml with distilled water, administration capacity 0.3ml/10 gram.
Experimental technique:
Animal is divided into 2 groups, often organizes 15.Fasting 12h before experiment, freely drinks water.Adopt gastric infusion, administration volume 0.3ml/10g, dosage is 7.5g/kg.Three administrations in one day, each minor tick 6h, integral dose is 22.5g/kg (be equivalent to 135 times of clinical plan consumption, body weight for humans presses 60kg).The abnormal response that after detailed record administration, animal occurs and death condition, Continuous Observation 7 days.The next day, weighs, and if any death, carries out pathological anatomy.Maximal tolerance dose multiple is calculated as follows: the dosage (g/kg) of dosage (g/kg)/mono-day people of maximal tolerance dose multiple=mouse.After result display mouse stomach gives a natural plant composition flavouring 22.5g/kg, the same day, Non Apparent Abnormality, observed none example death in 7 days.Mouse Weight increases normal.No. two natural plant composition flavouring mouse maximal tolerance doses are 22.5/kg, are equivalent to 135 times (people is by 60kg batheroom scales) of daily plan consumption.Tentatively show the security of No. two natural plant composition flavouring.
Embodiment 5 one, No. two natural plant composition flavouring cause the impact of pigeon vomiting to cis-platinum
Animal used as test and material:
Healthy pigeon 70, male and female dual-purpose, regular grade, body weight 350 ± 15g.
One, No. two natural plant composition flavouring are prepared by the method for embodiment 1 and embodiment 2.Ondansetron hydrochloride sheet (4mg/ sheet, Qilu Pharmaceutical Co., Ltd.), cisplatin for inj (freeze-dried type) (10mg/ props up, Dezhou Deyao Pharmaceutical Co., Ltd).
Experimental technique: experiment modeling bibliography is commonly used cis-platinum and made pigeon emesis of chemotherapy model, cis-platinum 4.5mgkg.Once abdominal cavity injection, the vomiting that pigeon can be suitable for, Continuous Observation 1 month pigeon still survives, and repeating test is stablized.Healthy pigeon is normally raised 1 week, is then divided into 7 groups at random, often organize 10.That is: blank group, model group, Western medicine Ondansetron group (2mgkg
-1d
-1), a natural plant composition flavouring high dose group (30g.kg
-1.d
-1) (being called for short a high dose), middle dosage group (20g.kg
-1.d
-1) (in being called for short No. one dosage), No. two natural plant composition flavouring high dose group (30g.kg
-1.d
-1) (being called for short No. two high doses), middle dosage group (20g.kg
-1.d
-1) (in being called for short No. two dosage) etc. 7 groups is for observing the effect of natural plant composition flavouring Prophylactic chemotherapy acute vomiting.
Experimental administration: each administration group gastric infusion, capacity is each 10mLkg
-1, for the every day interval multiple dosing of over capacity person, blank group, model group give equivalent distilled water.Natural plant composition flavouring totally 4 groups before the test 3 days start administration for three days on end, Western medicine Ondansetron group shifts to an earlier date administration in 15 minutes, blank group lumbar injection normal salt.
Experimental index is the pharmacodynamic effects understanding natural plant composition flavouring prevention and therapy emesis of chemotherapy, we are to vomit incubation period (to the time occurring to vomit for the 1st time after referring to chemotherapy), (from pigeon, vomiting is designated as 1 time to a burst of vomiting stopping to vomiting number of times, namely neck is stretched when vomiting occurs pigeon, dehisce, shrug, belly is contracted to and restores calm, or vomiting action stops), vomiting frequency (refers to stretch neck in pigeon vomiting process at every turn, dehisce, shrug, the number of times of the actions such as belly contraction) be index, situation and the anomaly of vomiting is there is in 5h after observation and comparison pigeon lumbar injection cis-platinum.
After observing model group chemotherapy in experimentation, pigeon haves the fidgets, and the phenomenon such as occur scratching, thirsty is serious, and vomiting is in paroxysmal.All the other respectively after group chemotherapy pigeon comparatively model group is comparatively quiet, though have scratching in various degree, the phenomenon such as thirsty, comparatively model group is light.To vomit incubation period, vomiting number of times, vomiting frequency be the antiemetic drug effect that pharmacodynamic index observes natural plant composition flavouring.Experimental result shows: compare with model group, Western medicine Ondansetron group, and one, No. two natural plant composition flavouring group pigeon generation vomiting number of times is few, and statistical procedures has significant difference (P<O.05).Good prevention effect is had to the vomiting that chemotherapy causes from visible one, No. two natural plant composition flavouring of the data of table 1.
Table 1 one, No. two natural plant composition flavouring are on the impact of the vomiting that chemotherapeutic causes
Note: compare * p ﹤ 0.05 with model group
The impact that embodiment 6 one, No. two natural plant composition flavouring increase apocleisis rats eating amount and body weight
Animal used as test and material:
Animal used as test: SD big white mouse is provided by Department of Health of Guangdong Province medical experimental animal, body weight 50-80g.One, No. two natural plant composition flavouring are prepared by the method for embodiment 1 and embodiment 2.Making special feed by oneself adopts fish floss, milk powder, corn flour, analysis for soybean powder, white sugar, fresh hen egg, fresh fat meat according to the mixing of l:l:l:2:1:2:2 ratio, and fish floss, milk powder, corn flour, analysis for soybean powder, white sugar, fresh hen egg, fresh fat meat are all purchased from supermarket.
Method and result:
Get children big white mouse 70 in age, body weight 50-80g, male and female half and half, random point 7 groups, wherein 6 groups with special forage feed modeling, and to feed with conventional feed and do blank group for another 1 group, the single cage of all animals is raised, and ad lib is drunk water, and raises 4 weeks altogether.Within 8th day, start the dosage by regulation in modeling, every day 1 time, blank group and model group give equal-volume distilled water, a natural plant composition flavouring high dose group (30g.kg
-1.d
-1) (being called for short a high dose), middle dosage group (20g.kg
-1.d
-1) (in being called for short No. one dosage), No. two natural plant composition flavouring high dose group (30g.kg
-1.d
-1) (being called for short No. two high doses), middle dosage group (20g.kg
-1.d
-1) (in being called for short No. two dosage), gastric infusion totally 3 weeks, experimental session, claims weekly 1 body weight and claims 1 daily inleting appetite weekly.
The impact that table 2 one, No. two natural plant composition flavouring increase apocleisis rat model body weight
Note: compare * p ﹤ 0.05 with blank group, compares * * p ﹤ 0.05 with model group
Table 3 one, No. two natural plant composition flavouring are on the impact of apocleisis rat model food-intake
Note: compare * p ﹤ 0.05 with blank group, compares * * p ﹤ 0.05 with model group
From table 2, table 3, model group and each administration group rat after modeling the 7th day food-intake, body weight all lower than blank group, have statistical significance (P<O.05) with blank group comparing difference, prompting modeling success.From the 14th day, the food-intake of each administration group rat and body weight obviously increased, and the food-intake of each administration group rat and body weight obviously increase has statistical significance (P<0.05) with model group than difference.Experimental result display one, No. two natural plant composition flavouring increases apocleisis rat model body weight and food-intake has a better role.
Claims (2)
1. a natural plant composition flavouring, is characterized in that being made up of the component of following ratio of weight and number:
Six kinds of raw-material ratios of weight and number are, unit 100 grams: Moringa Moringa oleifera 30, Chinese toon 20, Fructus Amomi 3, citrus chachiensis hortorum 6, Pogostemon cablin 6 and cloves 3; Cleaned by the clean running water of material, microwave drying, coordinates by weight, and pulverize, sieve 80-200 order, then mix, and uses microwave method sterilizing, and packaging gets product 6.2 kilograms.
2. natural plant composition flavouring described in claim 1 is in the application preparing treatment n and V or improve in appetite medicine.
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| CN104770698A (en) * | 2015-04-20 | 2015-07-15 | 王永帮 | Special seasoning powder for grilled fish and preparation method of special seasoning powder |
| CN106262635A (en) * | 2016-09-29 | 2017-01-04 | 广州市汇吉科技企业孵化器有限公司 | A kind of Moringa health care seasoning matter and preparation method thereof |
| CN106418420A (en) * | 2016-09-29 | 2017-02-22 | 广州市汇吉科技企业孵化器有限公司 | Fully vegetarian moringa oleifera seasoning materials and preparation method thereof |
| CN109198079A (en) * | 2017-07-04 | 2019-01-15 | 安恒利 | A kind of technology preparing natural high protein weight reducing scented tea with leaf of Moringa and Chinese toon |
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| CN101313741A (en) * | 2007-06-01 | 2008-12-03 | 顾安蓓 | Method of preparing novel composite aromatic condiment |
| CN102920754A (en) * | 2012-11-26 | 2013-02-13 | 北京盈良安生物科技有限公司 | Moringa leaf extract and application of moringa leaf extract in aspect of effect enhancement and toxicity reduction for chemotherapy or radiotherapy of cancers |
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