CN102920754A - Moringa leaf extract and application of moringa leaf extract in aspect of effect enhancement and toxicity reduction for chemotherapy or radiotherapy of cancers - Google Patents
Moringa leaf extract and application of moringa leaf extract in aspect of effect enhancement and toxicity reduction for chemotherapy or radiotherapy of cancers Download PDFInfo
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Abstract
The invention discloses a moringa leaf extract and an application of the moringa leaf extract in the aspects of effect enhancement and toxicity reduction for chemotherapy or radiotherapy of cancers. Dry moringa leaves are extracted through 20%-80% ethanol aqueous solution the amount of which is 3-10 times of the weight of the dry moringa leaves, concentrated and dried so as to obtain the moringa leaf extract. The moringa leaf extract which is extracted through the method has the functions of effect enhancement and toxicity reduction for chemotherapy or radiotherapy of cancers, and can be used for producing various auxiliary anti-cancer medicaments, functional food and food.
Description
Technical field
The present invention relates to the Moringa extract to efficacy enhancing and toxicity reducing effect and the application thereof of cancer in chemotherapy and radiation.
Background technology
Cancer has become a global problem.According to statistics, the present annual whole world has 1,200 ten thousand people newly to be diagnosed as cancer, and 7,600,000 people die from cancer.And the sickness rate of cancer is also in continuous increase, if hold fire, estimates that will there be 2,600 ten thousand newly-increased cases in the year two thousand thirty whole world, and death toll reaches 1,700 ten thousand people, and wherein most of cases will occur in the developing country of middle and low income.According to World Health Organization (WHO) statistics, the eighties in 20th century, the annual new cancered patient in the whole world was about 7,000,000, died from about 6,700,000 people of cancer person every year.Early 1950s, Cancer in China death accounts for the 9th or the 10th of whole causes of the death, and the seventies, cancer mortality leapt to the 3rd.Since the eighties in 20th century, the cancer morbidity of China is always in rising trend, and the number of the infected of present annual cancer is about 4,000,000, and the number of dying from cancer surpasses 3,700,000.So invention cancer therapy drug and treatment cancer new method have been the hot research fields of medical science circle since eighties of last century the seventies always.
Cancer is a kind of machine-processed not normal disease that causes owing to human body control growth and proliferation of cell, and the Main Means of its treatment has surgical operation therapy, radiotherapy, chemotherapy and also adopt the Chinese Traditional Medicine treatment in China's Mainland and whole world Chinese.
1. operative treatment
(1) radical surgery
Because malignant growth is fast, the surface does not have peplos, and it and normal surrounding tissue do not have obvious boundary, and local infiltration is severe, can also shift by lymphatic vessel.Therefore, operation will be tumor and normal structure and the lymph node that may be invaded of certain limit thoroughly excise on every side.This operation is suitable for range of tumor and limits to, do not have metastasis, patient that body constitution is good.
(2) palliative operation
Range of tumor is wider, and existing transfer the and can not do the end-stage patients of radical surgery for palliating the agonizing sufferings, kept nutrition and extending life, can a cut-out tumor or do some the operation of mitigation symptoms, and such as fistulation etc.
(3) detecting property operation
To swollen thing in the internal organs in deep, when sometimes can not determine its character through various inspections, need to open breast, open abdomen or open the form that cranium checks lump, distinguish its character or cut a fritter living tissue quick frozen-section inspection, to determine therapeutic scheme.
2. radiotherapy
Radiotherapy is called for short radiotherapy, utilizes the suitable position of high-energy electromagnetic radiation roentgenization health, and biomolecular structure is changed or direct killing tissue and cell, reaches the purpose of destroying cancer.
3. chemotherapy
Chemotherapy is oral administration or injection chemotherapeutics, is also referred to as " born of the same parents poison therapy ", because used medicine all is harmful, or even with toxicity, normal cell and cancerous cell there are injury effect.
Chemotherapeutical clinical practice has four kinds of modes:
1. the systemic chemotherapy of late period or dissemination tumor because this class tumor patient is lacked other effective Therapeutic Method usually, usually adopts chemotherapy at the very start, and recent purpose is to obtain alleviation.
2. adjuvant chemotherapy, refer to topical therapeutic (operation or radiotherapy) after, for the small metastatic lesion that may exist, prevent its recurrence or transfer and the chemotherapy of carrying out.
3. new adjuvant chemotherapy, for comparatively circumscribed tumor clinically, but excision or radiotherapy acquire a certain degree of difficulty, and can use first chemotherapy before operation or radiotherapy.
4. special pathway chemotherapy, (1) intracavitary therapy.(2) canalis spinalis chemotherapy.(3) Arterial Chemotherapy.
Most patient has been middle and advanced stage when China's cancer is found, and has lost the chance of radical operation, so can only carry out palliative Radiotherapy chemotherapy; Be simultaneously operating patient also almost to carrying out Radiotherapy chemotherapy to strengthen and to consolidate curative effect in case shift and recurrence, and Radiotherapy chemotherapy has great injury effect to human body, in order to reduce such injury effect, the various countries scientist ceaselessly seeks material and the method that Radiotherapy chemotherapy is had potentiation and Attenuation.
We find that some have the natural medicinal plant kind of better potentiation and Attenuation to cancer in radiation and chemotherapy in the research of long-term excavation world natural medicinal plant resource.
Moringa is Moringaceae Moringa plant Moringa oleifera, is a kind of tropical plants that unique economic worth is arranged.Undergraduate course only has a genus, totally 14 kinds.Wherein M.stenopetala is distributed in that Ethiopia and Kenya are northern, M.peregrina is distributed in the Sudan, Egypt and the Arabia Peninsula, M.ovalifolia is distributed in Angola and Namibia, M.oleifera are distributed in the inferior Himalaya of north India zone, and oneself has cultivation these 4 kinds.What we studied and used is this kind of Moringa M.oleifera, the blade of Moringa and fruit are rich in several mineral materials, vitamin and health care and medicinal chemical constituent, can be used as vegetable and food, have to supplement the nutrients and the Dietotherapy health function, also can be used for the control some diseases.Folk tradition is thought that Moringa has and is brought down a fever, antiinflammatory, calculus, diuresis, blood pressure lowering, pain relieving, heart tonifying, urges the functions such as wish.India and African country are usually used in treating the various diseases such as diabetes, hypertension, cardiovascular diseases, obesity, dermatosis, ophthalmic, hypoimmunity, vitamin C deficiency, anemia, arthritis, rheumatism, digestive system tumor.There is bibliographical information to studies show that blade, fruit and the root of Moringa contain and reduces blood pressure and the chemical constituent of cholesterol, have no report Moringa leaf extract to the efficacy enhancing and toxicity reducing effect of cancer chemotherapy or radiotherapy.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of Moringa leaf extract and the preparation to the application in the efficacy enhancing and toxicity reducing drugs with function in cancer chemotherapy or the radiotherapy.
To achieve these goals, the present invention adopts following technical scheme:
A kind of Moringa leaf extract is prepared from by the following method:
With the Moringa blade of drying, with the 20%-80%(percent by volume of 3-10 times of weight) ethanol water extract, concentrated, dry Moringa leaf extract.
In above-mentioned Moringa leaf extract, described method comprises the steps:
Moringa blade with drying, 20%-80%(percent by volume with 3-10 times of weight) ethanol water soaked 4-48 hour at 15-60 ℃, leach liquid, repeat 1 or 2 time, merging filtrate and being evaporated to is done or spray drying namely gets the Moringa leaf extract.
Or:
With the Moringa blade of drying, with the 20%-80%(percent by volume of 3-10 times of weight) ethanol water reflux, extract, under heating in water bath, leach filtrate, be concentrated into driedly, get the Moringa leaf extract.
Compared with prior art, the present invention has following beneficial effect: the Moringa leaf extract of extracting method gained of the present invention has cancer in the efficacy enhancing and toxicity reducing effect of chemotherapy or radiotherapy, can be for the preparation of various auxiliary cancer therapy drugs, functional food and food.
The specific embodiment
The preparation of embodiment 1 Moringa leaf extract
1 kilogram of Moringa cured leaf powder is placed in the sealable container, adds 4 kilograms 60% ethanol water soaking at room temperature 48 hours, leach filtrate, repeat to soak 1 time, merging filtrate is evaporated to dried, obtains taupe solid 118 grams.
The preparation of embodiment 2 Moringa leaf extracts
1 kilogram of Moringa cured leaf powder is placed in the heating and refluxing extraction container, and 80% the ethanol water that adds 4 kilograms refluxed 5 hours at heating in water bath, leached filtrate, was evaporated to driedly, obtained taupe solid 120 grams.The preparation of embodiment 3 Moringa leaf extracts
1 kilogram of Moringa cured leaf powder is placed in the sealable container, and 20% the ethanol water that adds 6 kilograms soaked 10 hours at 60 ℃, leached filtrate, repeated to soak 2 times, and merging filtrate is evaporated to dried, obtained taupe solid 121 grams.
Embodiment 4: the extract of embodiment 1 gained suppresses mice S to 5-Fu
180The impact of sarcoma effect and body weight
Material: the Moringa leaf extract is provided by this research group.Reference substance 5-Fu Wuhan Yuanda Pharmaceutical Group Co., Ltd. produces.The NIH white mice is provided by Department of Health of Guangdong Province medical experimental animal field.Tumor strain S
180Mice is provided by the Zhongshan University institute of oncology, inoculates into routinely solid tumor before the experiment.
Method: the Moringa leaf extract suppresses S to 5-Fu
180The impact of sarcoma effect and body weight.
Choose 120 of same sex NIH mices, body weight 20 ± 2g gets 7～9 days S of growth
180Cancer ascites is diluted by 1: 1 with sterile saline respectively, with S
180Cancerous cell be inoculated in the subcutaneous 0.2ml/ of NIH right side of mice axillary fossa only (3.6 * 107/ml), postvaccinal mice is by the body weight grouping, grouping and route of administration see Table 1.Inoculate and begin oral administration next day, once a day, dosage (1.5g)+5-fluorouracil group and Moringa high dose (3.0g)+5-fluorouracil group give respectively Moringa extract and negative group to the equivalent normal saline in Moringa group (3.0g), the Moringa, continuous ten days; Dosage in the Moringa+5-fluorouracil group, Moringa high dose+5-fluorouracil group and positive component do not give 5-fluorouracil in intraperitoneal administration 20mg/Kg on the the 1st, 5,7.Put to death mice in the 11 day, and stripped sarcoma, weigh with torsion balance, calculate tumour inhibiting rate.
As seen from Table 1, the Moringa extract adds the 5-fluorouracil group and increases with the suppression ratio that simple 5-fluorouracil group compares cancer, and last terminal hour Mouse Weight is larger, so show the Moringa extract 5-fluorouracil is suppressed S
180Sarcoma has preferably efficacy enhancing and toxicity reducing impact.
Table 1 Moringa extract suppresses S to 5-fluorouracil
180The impact of sarcoma effect and body weight
Embodiment 5: the extract of embodiment 2 gained suppresses mice S to cyclophosphamide
180The impact of sarcoma effect and body weight
Material: the Moringa leaf extract is provided by this research group.Cyclophosphamide (CY), Hainan Chang'an International Pharmaceutical Co., Ltd produces.The NIH white mice is provided by Department of Health of Guangdong Province medical experimental animal field.White mice hepatic ascites tumor is provided by the Zhongshan University institute of oncology.Inoculate into routinely solid tumor before the experiment.
Method: the Moringa leaf extract suppresses S to cyclophosphamide
180The impact of sarcoma effect and body weight.
Choose 120 of same sex NIH mices, body weight 20 ± 2g gets 7～9 days S of growth
180Cancer ascites is diluted by 1: 1 with sterile saline respectively, with S
180Cancerous cell be inoculated in the subcutaneous 0.2ml/ of NIH right side of mice axillary fossa only (3.6 * 107/ml), postvaccinal mice is by the body weight grouping, grouping and route of administration see Table 2.Inoculate and begin oral administration next day, once a day, dosage (1.5g)+cyclophosphamide group and Moringa high dose (3.0g)+cyclophosphamide group give respectively Moringa extract and negative group to the equivalent normal saline in Moringa group (3.0g), the Moringa, continuous ten days; Dosage in the Moringa+cyclophosphamide group, Moringa high dose+cyclophosphamide group and positive component do not give positive group and are 10mg/kg cyclophosphamide, successive administration ten days.Put to death mice in the 11 day, and stripped sarcoma, weigh with torsion balance, calculate tumour inhibiting rate.
Table 2 Moringa extract suppresses the impact of hepatocarcinoma sarcoma effect and body weight on cyclophosphamide
By as seen from Table 2, the Moringa extract adds the suppression ratio that cyclophosphamide group and simple ring phosphamide group compare cancer and increases, and last terminal hour Mouse Weight is larger, so show that the Moringa extract suppresses the hepatocarcinoma sarcoma to cyclophosphamide preferably efficacy enhancing and toxicity reducing impact is arranged.
Embodiment 6: the Moringa extract of embodiment 1 gained is on the impact of the anti-x-ray radiation effect of mice
Materials and methods
1. laboratory animal: the NIH white mice is provided by Department of Health of Guangdong Province medical experimental animal field, male and female dual-purpose, body weight (20 ± 2) g.
2. Moringa leaf extract: be mixed with the aqueous solution that contains crude drug 1g/ml.
Method and result
Observe the Moringa leaf extract of various dose to the impact of the survival rate of deep X-ray irradiation mice.100 of mices are divided 5 groups at random, gastric infusion, experiment mice is divided into Normal group (gavage normal saline 20ml/kg body weight at random, do not add irradiation), irradiation control group (gavage normal saline 20ml/kg body weight, add irradiation), with Moringa extract low dosage experimental group (gavage Moringa extract 5g/kg+ normal saline 15g/kg body weight, add irradiation), dosage experiments group in the Moringa extract (gavage Moringa extract 10g/kg+ normal saline 10g/kg body weight adds irradiation), Moringa extract high dose experimental group (gavage Moringa extract 20g/kg body weight, add irradiation), the pre-irradiation administration, once a day, after continuous 10 days, with philips deep X ray one subtotal body irradiation, spacing mice centre distance 40cm, exposure rate 8.51 * 10-5C.kg.min(33 human relations/minute), continuous 12 minutes, accumulated dose 5gy observes dead mouse number in 30 days after the irradiation.The result shows that the survival rate of radiation matched group is followed successively by Normal group 100%, irradiation control group 23.1%, low dose group 32.2%, middle dosage group 39.2%, high dose group 56.2%.Moringa extract experimental group has significance (P＜0.05) with irradiation control group than difference.
Conclusion: the Moringa extract has certain protective effect to the anti-X-radiation of mice.
Embodiment 7: the extract of embodiment 2 gained is on the impact of the anti-cobalt-60γray radiation effects of mice
Materials and methods
1. laboratory animal: the NIH white mice is provided by Department of Health of Guangdong Province medical experimental animal field, male and female dual-purpose, body weight (20 ± 2) g.
2. Moringa leaf extract: be mixed with the aqueous solution that contains crude drug 1g/ml.
3. illuminate condition: adopt
60Co gamma-rays one subtotal body irradiation, absorbed dose rate are 0.544Gy.min-1, and total absorbed dose is respectively 7.20Gy (observation survival rate) and 4.50Gy (observing the hemopoietic system index).
4. experimental technique: 100 of experiment mices are divided into five groups at random, Normal group (gavage normal saline 10ml/kg body weight does not add irradiation), irradiation control group (gavage normal saline 10ml/kg body weight adds irradiation), with Moringa extract low dosage experimental group (gavage Moringa extract 6g/kg body weight adds irradiation), dosage experiments group in the Moringa extract (gavage Moringa extract 12g/kg body weight adds irradiation), Moringa extract high dose experimental group (gavage Moringa extract 24g/kg body weight adds irradiation), the pre-irradiation administration, once a day, continuous 7 days.Observed and recorded is respectively organized survival period and 30 days survival rates of mice after the irradiation.
Interpretation of result:
Impact on the mouse storaging current rate: Normal group (20) average survival time was was greater than 30 days, Moringa extract low dosage experimental group (20) is (19.5 ± 2.2) sky, dosage experiments group in the Moringa extract (20) is (22.5 ± 3.3) sky, Moringa extract high dose experimental group (20) is (24.5 ± 4.5) sky, irradiation control group (20) is (19.2 ± 2.3) sky, the Chinese medicine experimental group is compared with the irradiation control group survival time of mice, through t check difference very significant (P＜0.01) is arranged.The survival rate Normal group was 100% in 30 days, Moringa extract low dosage experimental group is 8.5%, the dosage experiments group is 17.5% in the Moringa extract, Moringa extract high dose experimental group is 35.5%, irradiation control group is 8.3%, and Moringa extract experimental group has significance (P＜0.05) with irradiation control group than difference.
Conclusion: the Moringa extract has certain protective effect to the anti-cobalt-60γray radiation of mice.
Claims (4)
1. Moringa leaf extract is characterized in that being prepared from by the following method:
With the Moringa blade of drying, extract with the ethanol water of the 20%-80% of 3-10 times of weight, concentrated, dry Moringa leaf extract.
2. Moringa leaf extract as claimed in claim 1 is characterized in that described method comprises the steps:
With the Moringa blade of drying, soaked 4-48 hour at 15-60 ℃ with the ethanol water of the 20%-80% of 3-10 times of weight, leach liquid, repeats merging filtrate and be evaporated to dried or spray drying namely gets the Moringa leaf extract 1 or 2 time.
3. Moringa leaf extract as claimed in claim 1 is characterized in that described method comprises the steps:
With the Moringa blade of drying, the ethanol water reflux, extract, under heating in water bath with the 20%-80% of 3-10 times of weight leaches filtrate, is concentrated into driedly, gets the Moringa leaf extract.
4. the efficacy enhancing and toxicity reducing drugs with function of the described Moringa leaf extract of claim 1 in preparation cancer chemotherapy or radiotherapy, the application in health product or the food.
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| CN103330175A (en) * | 2013-06-07 | 2013-10-02 | 北京盈良安生物科技有限公司 | Seasoning made of natural plant compositions and preparation method thereof |
| CN103583930A (en) * | 2013-11-08 | 2014-02-19 | 唐国平 | Moringa oleifera leaf detoxifying method and application of moringa oleifera leaf product |
| CN103652930A (en) * | 2013-12-31 | 2014-03-26 | 广州天来宝生物科技有限公司 | Moringa calcium total nutrient and preparation method thereof |
| CN104224862A (en) * | 2013-06-07 | 2014-12-24 | 韩国原子力研究院 | Composition containing moringa oleifera leave water soluble extract as effective component and used for treating or preventing cancer and preparation method for moringa oleifera leave extract |
| CN104232727A (en) * | 2014-09-11 | 2014-12-24 | 浙江省林业科学研究院 | Method for preparing germanium-enriched phellinus igniarius fermentation product |
| CN105769944A (en) * | 2016-03-11 | 2016-07-20 | 田洋 | Moringa oleifera extract with weight reducing effect, as well as preparation method and use of moringa oleifera extract |
| CN106456687A (en) * | 2014-06-18 | 2017-02-22 | 韩国原子力研究院 | Composition for radiation combined treatment, containing moringa oleifera leaf extract, and treatment method using same |
| WO2018178886A1 (en) * | 2017-03-30 | 2018-10-04 | Specchiasol S.R.L. | Method for realization of dried extracts, hydro-alcoholic extracts and protein powders derived of leaves and plant seeds of moringa oleifera. |
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| CN103330175A (en) * | 2013-06-07 | 2013-10-02 | 北京盈良安生物科技有限公司 | Seasoning made of natural plant compositions and preparation method thereof |
| CN104224862A (en) * | 2013-06-07 | 2014-12-24 | 韩国原子力研究院 | Composition containing moringa oleifera leave water soluble extract as effective component and used for treating or preventing cancer and preparation method for moringa oleifera leave extract |
| CN103330175B (en) * | 2013-06-07 | 2015-02-04 | 北京盈良安生物科技有限公司 | Seasoning made of natural plant compositions and preparation method thereof |
| CN104224862B (en) * | 2013-06-07 | 2018-05-25 | 韩国原子力研究院 | Water-soluble extractive containing leaf of Moringa is used to treat or prevent the composition of cancer and the preparation method of moringa oleifera leaf extractive for active ingredient |
| CN103583930A (en) * | 2013-11-08 | 2014-02-19 | 唐国平 | Moringa oleifera leaf detoxifying method and application of moringa oleifera leaf product |
| CN103652930A (en) * | 2013-12-31 | 2014-03-26 | 广州天来宝生物科技有限公司 | Moringa calcium total nutrient and preparation method thereof |
| CN103652930B (en) * | 2013-12-31 | 2015-07-08 | 广州天来宝生物科技有限公司 | Moringa calcium total nutrient and preparation method thereof |
| CN106456687A (en) * | 2014-06-18 | 2017-02-22 | 韩国原子力研究院 | Composition for radiation combined treatment, containing moringa oleifera leaf extract, and treatment method using same |
| CN104232727A (en) * | 2014-09-11 | 2014-12-24 | 浙江省林业科学研究院 | Method for preparing germanium-enriched phellinus igniarius fermentation product |
| CN105769944A (en) * | 2016-03-11 | 2016-07-20 | 田洋 | Moringa oleifera extract with weight reducing effect, as well as preparation method and use of moringa oleifera extract |
| WO2018178886A1 (en) * | 2017-03-30 | 2018-10-04 | Specchiasol S.R.L. | Method for realization of dried extracts, hydro-alcoholic extracts and protein powders derived of leaves and plant seeds of moringa oleifera. |
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Application publication date: 20130213 |