CN111381057A

CN111381057A - Sample analyzer and control method thereof

Info

Publication number: CN111381057A
Application number: CN201811642386.0A
Authority: CN
Inventors: 王锐; 周宇航; 刘治志
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2018-12-29
Filing date: 2018-12-29
Publication date: 2020-07-07
Anticipated expiration: 2038-12-29
Also published as: CN111381057B

Abstract

A sample analyzer and a control method thereof. The application discloses sample analyzer, this sample analyzer includes: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing the sample contained in the sample container or recycling the sample container; the first guide piece is fixed relative to the base; and the grabbing and releasing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and releases the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device. In this way, under the condition that the normal use of the sample analyzer is not influenced, the miniaturized design of the sample analyzer is convenient, and the working efficiency is improved.

Description

Sample analyzer and control method thereof

Technical Field

The invention relates to the technical field of medical equipment, in particular to a sample analyzer and a control method thereof.

Background

Currently, in sample analyzers, the movement of the sample container between the incubation plate, the magnetic separation, the gripper and the waste cup channel is performed by a mechanical swing arm. The orbit of mechanical cantilever motion is circular orbit, this requires that the spatial layout of incubation dish, magnetic separation and useless cup passageway need be on same horizontal plane, and can't lay out other parts again on the cantilever motion space to satisfy the required space of cantilever swing, thereby lead to the volume of sample analysis appearance great, be not convenient for carry and can occupy great place the space, in addition, mechanical swing arm's work efficiency is lower.

Disclosure of Invention

The technical problem that this application mainly solved provides a sample analysis appearance and control method thereof, can be under the circumstances that does not influence sample analysis appearance normal use, the miniaturized design of the sample analysis appearance of being convenient for, and can improve work efficiency.

In order to solve the above technical problem, one technical solution adopted in the embodiments of the present application is: providing a sample analyzer, the sample analyzer comprising: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing the sample contained in the sample container or recycling the sample container; the first guide piece is fixed relative to the base; and the grabbing and releasing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and releases the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device.

In order to solve the above technical problem, another technical solution adopted in the embodiment of the present application is: there is provided a control method of a sample analyzer, the control method including: controlling the grabbing and releasing device to move on the first guide piece along the first direction to a position corresponding to one of the at least two processing devices; controlling the grabbing and releasing device to grab the sample container at the processing device; controlling the grabbing and releasing device to move on the first guide piece along the first direction to a position corresponding to the other processing device in the at least two processing devices; the pick-and-place device is controlled to release the sample container to place the sample container at another processing device.

This application embodiment includes through setting up sample analyzer: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing the sample contained in the sample container or recycling the sample container; the first guide piece is fixed relative to the base; and the grabbing and releasing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and releases the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device. The grabbing and releasing device is movably arranged on the first guide piece along the first direction and moves along the length direction of the first guide piece, so that the grabbing and releasing device occupies a small space for movement, and the miniaturization design of the sample analyzer can be facilitated under the condition that the normal use of the sample analyzer is not influenced; in addition, the grabbing and placing device moves on the first guide piece, and the working efficiency is higher.

Drawings

FIG. 1 is a schematic perspective view of a sample analyzer according to an embodiment of the present application;

FIG. 2 is a schematic diagram of another perspective view of a sample analyzer according to an embodiment of the present application;

fig. 3 is a schematic structural diagram of a second rotating disk of an incubation device according to an embodiment of the present application.

FIG. 4 is a schematic structural diagram of a magnetic separation device according to an embodiment of the present application;

FIG. 5 is a schematic structural diagram of a first embodiment of a magnetic element layout according to an example of the present application;

FIG. 6 is a schematic diagram showing the position relationship between the detecting unit and the magnetic separating unit according to the embodiment of the present application;

FIG. 7 is a schematic top view of a first embodiment of a magnetic element layout according to the present application;

FIG. 8 is a schematic diagram illustrating a positional relationship among the magnetic members, the turntable, and the accommodating hole according to the first embodiment of the magnetic member layout of the present application;

FIG. 9 is a schematic view of the magnetic attraction principle of the first arrangement of the magnetic members according to the present application;

FIG. 10 is a schematic structural diagram of a push-pull mechanism according to an embodiment of the present application;

FIG. 11 is a schematic diagram of a third exemplary inspection station of the present application;

FIG. 12 is a schematic diagram of a fourth inspection station embodiment of the present application;

FIG. 13 is a schematic structural diagram of magnetic members according to a second magnetic member layout manner in the embodiment of the present application;

FIG. 14 is a schematic diagram of a fifth exemplary inspection station according to the present disclosure;

FIG. 15 is a schematic diagram of a sixth inspection station according to an embodiment of the present disclosure;

FIG. 16 is a schematic view of the magnetic attraction principle of the third magnetic element layout of the present application;

FIG. 17 is a schematic diagram of a seventh inspection station in accordance with an embodiment of the present disclosure;

fig. 18 is a schematic flow chart of a first embodiment of a control method of the sample analyzer of the present application.

Detailed Description

Referring to fig. 1 and fig. 2, fig. 1 is a schematic perspective view of a sample analyzer according to an embodiment of the present application, and fig. 2 is a schematic perspective view of another sample analyzer according to an embodiment of the present application.

In this embodiment, the sample analyzer may include: a base 10 ', at least two processing devices 21', 22 ', 23', a first guide 30 'and a pick-and-place device 40'.

The base 10 'is placed on a work table, and the lower surface of the base 10' is in contact with the work table. It should be noted that the following descriptions of the orientations, such as "above", "below", "upper surface", "lower surface", etc., are based on the lower surface of the base 10'.

The processing device 21 ', the processing device 22', and the processing device 23 'are disposed on the upper surface of the susceptor 10' directly or indirectly.

The processing device 21 ', 22', or 23 'is used for placing the sample container c' and processing the sample contained in the sample container c 'or recovering the sample container c'.

The catch device 40 'is movably arranged on the first guide 30' in a first direction.

The grasping and releasing device 40 'is used to grasp or release the sample container c' so as to transfer the sample container c 'between any two of the processing device 21', the processing device 22 ', and the processing device 23'.

For example, the transfer of the sample container c ' between the processing apparatus 21 ' and the processing apparatus 22 ' will be described as an example. The catching device 40 ' catches the sample container c at the processing device 21 ' after moving to a corresponding position of the processing device 21 ' in the first direction, and releases the sample container c ' after moving to a corresponding position of the processing device 22 ' in the first direction to place the sample container c ' at another processing device 22 '.

The first direction is a length direction of the first guide 30'.

Alternatively, the processing device 21 'may be a magnetic separation device 21'. The processing device 22 'may be an incubation device 22'.

The magnetic separation device 21 'is used for performing magnetic separation treatment on the sample in the sample container c', and the incubation device 22 'is used for performing incubation treatment on the sample in the sample container c'.

Alternatively, the processing device 23 'may be a container recovery device 23', the container recovery device 23 'being adapted to receive a used sample container c'. For example, the holding and releasing device 40 ' transfers the used sample container c ' in the incubation device 22 ' or the magnetic separation device 21 ' to the container recovery device 23 '.

Referring to fig. 3, fig. 3 is a schematic structural diagram of a second rotating disc of an incubation device according to an embodiment of the present disclosure. Optionally, the magnetic separating device 21 'includes a first base 211' and a first rotating disk 212 'rotatably connected to the first base 211', and the first rotating disk 212 'is provided with at least one first receiving hole a'. The incubation device 22 'includes a second base 221' and a second rotating disc 222 'rotatably connected to the second base 221', the second rotating disc 222 'is provided with at least one second receiving hole b', and the container recycling device 23 'has a receiving channel 231'. The second base 221 'covers the top and the periphery of the second rotating disk 222' to prevent heat dissipation. Since the second turntable 222' cannot be shown in fig. 1 and 2, please understand in conjunction with fig. 3.

For example, taking the sample container c transferred between the magnetic separation device 21 ' and the incubation device 22 ' as an illustration, the first and second rotatable disks 212 ' and 222 ' are rotated to position the predetermined first and second receiving holes a ' and b ' at corresponding positions of the first guide 30 ', so that the pick-and-place device 40 ' can transfer the sample container c ' between the predetermined first and second receiving holes a ' and b '.

For another example, when it is desired to transfer the sample container c 'between the magnetic separation device 21', the incubation device 22 ', and the receiving channel 231', the holding device 40 'can transfer the sample container c' between the predetermined first receiving hole a ', the predetermined second receiving hole b', and the receiving channel 231 'by rotating the first rotary disk 212' and the second rotary disk 222 'such that the predetermined first receiving hole a', the predetermined second receiving hole b ', and the receiving channel 231' are located at corresponding positions of the first guide member 30 ', and the predetermined first receiving hole a', the predetermined second receiving hole b ', and the receiving channel 231' are located on a straight line.

Through the mode, the moving path of the grabbing and placing device 40 'among the magnetic separation device 21', the incubation device 22 'and the container recovery device 23' is a straight line, compared with the circular motion track of the traditional swing arm, the moving device greatly saves the space required by the motion, and can improve the working efficiency of the transfer.

The relative position of the first guide 30 'and the base 10' is fixed.

The first guide 30 ' may be directly fixed to the base 10 ', or may be indirectly fixed to the base 10 ' by another member. The vertical distance from any point on the first guide 30 'to the lower surface of the base 10' is greater than the vertical distance from any point on the processing device 12 'to the lower surface of the base 10'. For example, when the base 10 ' of the sample analyzer is placed on a horizontal work platform, the first guide 30 ' is located above the processing devices 21 ', 22 ', 23 '.

Optionally, the sample analyzer further includes a first fixing plate 50 ', and the first guide 30' is fixed to the base 10 'by the first fixing plate 50'.

In an exemplary embodiment, the sample analyzer further includes a first driving mechanism (not shown), which can be disposed on the first fixing plate 50 'and fixedly connected to the first fixing plate 50'. The first drive mechanism is used to drive the catch 40 'in a first direction on the first guide 30'.

The first driving mechanism may include a first motor, a first driving wheel, a first driven wheel, and a first driving belt. The first motor is fixedly disposed on the first fixing plate 50'. The first motor comprises a body and a rotating shaft driven by the body to rotate. The first driving wheel is fixedly sleeved on the rotating shaft of the first motor and rotates along with the rotating shaft of the first motor.

The first driven wheel is rotatably disposed on the first fixing plate 50', and the first driven wheel and the first driving wheel are spaced in the first direction.

The first transmission belt is lapped on the first driving wheel and the first driven wheel and is used for transmitting the torque on the first driving wheel to the first driven wheel.

The predetermined position of the first transmission belt in the length direction is fixedly connected with the grabbing and releasing device 40 ', and the first transmission belt is used for driving the grabbing and releasing device 40' to move back and forth in the first direction.

It should be understood that the specific structure of the first driving mechanism is not limited to the above structure, and the driving manner is not limited to the above manner, as long as the pick-and-place device 40 ' can be driven to move back and forth along the first guide 30 ' relative to the first fixing plate 50 '.

Through setting up first fixed plate 50 ', be favorable to setting up first actuating mechanism, and through setting up first guide 30' on first fixed plate 50 ', fix first fixed plate 50' on base 10 'again for first guide 30' with set up on first guide 30 'and grab and put device 40' and base 10 'relatively fixed, be convenient for first fixed plate 50' and set up the installation and the dismantlement of the subassembly on it, and then be favorable to the maintenance and the change of subassembly.

Optionally, the sample analyzer further includes a second fixing plate 60 ', the second fixing plate 60 ' being movably disposed on the first guide 30 ' in the first direction, and the catching and releasing device 40 ' being connected to the second fixing plate 60 '.

Optionally, the sample analyzer further includes a second guide 70 ', the second guide 70 ' is fixed to the second fixing plate 60 ', and the catching and releasing device 40 ' is movably disposed on the second guide 70 ' along a second direction, the first direction crossing the second direction.

The second direction is a length direction of the second guide 70'.

In an exemplary embodiment, the sample analyzer further includes a second driving mechanism (not shown), which can be disposed on the second fixing plate 60 'and fixedly connected to the second fixing plate 60'. The second drive mechanism is used to drive the pick-and-place device 40 'to move in the second direction on the second guide 70'.

The second driving mechanism may adopt a similar structure to the first driving mechanism, i.e., the second driving mechanism may include a second motor, a second driving wheel, a second driven wheel, and a second transmission belt. The second motor is fixedly disposed on the second fixing plate 60'. The second driving wheel is fixedly sleeved on the rotating shaft of the second motor and rotates along with the rotating shaft of the second motor. The second driven wheel is rotatably disposed on the second fixing plate 60', and the second driven wheel and the second driving wheel are spaced in the second direction. The second transmission belt is lapped on the second driving wheel and the second driven wheel. The second belt is fixedly connected with the holding and releasing device 40' at a preset position in the length direction.

In this way, the pick-and-place device 40 can move in the second direction along the second guide 70 ', and also can move in the first direction along with the second fixing plate 60 ' on the first guide 30 ', and the first direction intersects with the second direction, so that the pick-and-place device 40 can move in two different directions, so as to pick, move and place the sample containers c ' in at least two processing devices 21 ', 22 ' and 23 ' at different positions and on different planes, and further, the processing devices in the sample analyzer can be overlapped in the space along the second direction, which is more beneficial to the miniaturization design of the whole analyzer.

Optionally, the first direction is perpendicular to the second direction. For example, the first direction is a direction parallel to the upper surface of the first turntable 212 ', and the second direction is a direction perpendicular to the upper surface of the first turntable 212'. Specifically, when the base 10' of the sample analyzer is placed on a horizontal work platform, the first direction may be a horizontal direction, and the second direction may be a vertical direction.

Optionally, the sample analyzer further comprises a container adding means 80 ', the container adding means 80' being adapted to add a sample container c 'to the incubation means 22', the height of the container adding means 80 'relative to the base 10' being greater than the height of the incubation means 22 'relative to the base 10'. The fixing position of the first fixing plate 50 'on the container adding means 80' is higher than the position of the incubating means 22 'and higher than the position of the magnetic separating means 21'.

Optionally, the container adding device 80 'includes a device main body 81', a cartridge 82 'and a container channel 83', the cartridge 82 'is fixed on the base 10' through the device main body 81 ', the container channel 83' is connected to the cartridge 82 'at a bin outlet e' of the cartridge 82 ', the cartridge 82' has a bin inlet d 'at a side far away from the device main body 182', a sample container c 'is put into the cartridge 82' from the bin inlet d ', and the sample container c' in the cartridge 82 'is conveyed into the second accommodating hole b' of the incubation device 22 'through the container channel 83'. The height of the cartridge body 82 ' relative to the base 10 ' is greater than the height of the incubation device 22 ' relative to the base 10 ', so that the sample container c ' is fed into the second receiving hole b ' of the incubation device 22 ' after exiting from the outlet e ' through the container channel 83 '.

The sample container c 'in the cartridge 82' is transported to the incubation device through the container channel, the container channel 83 'includes a slide groove h1 and a regulating disc h2, the slide groove h1 is arranged obliquely relative to the bottom surface of the base 10', a plurality of placing holes f are arranged on the regulating disc h2, and the axial direction of the placing holes f is perpendicular to the bottom wall of the slide groove h 1. In this way, the sample container c 'can be made to fall onto the incubation device 22' under its own weight.

The container adding device 80 ' further comprises a spring sheet (not shown), one end of the spring sheet is fixed with the container channel 83 ', and the other end of the spring sheet extends into the bin outlet e ' and is used for removing the sample container c ' with an unsatisfactory posture, so that the bin outlet e ' is prevented from being blocked. The fixed position of the first retaining plate 50 'on the outer surface of the cartridge body 82' is higher than the position of the incubation device 22 'and higher than the position of the magnetic separation device 21'.

By fixing the first fixing plate 50 ' to the outer surface of the cartridge body 82 ', on one hand, the positional relationship of the cartridge body 82 ' above the incubation device 22 ' is utilized, and on the other hand, the base 10 ' does not need to be provided with a portion for fixing the first fixing plate 50 ', thereby simplifying the structure of the base 10 ' and further reducing the overall volume of the sample analyzer.

Optionally, the height of the base 10 'relative to the position where the incubation device 22' places the sample container c 'is greater than the height of the base 10' relative to the position where the magnetic separation device 21 'places the sample container c'.

In this way, the incubation device 22 'is located above the magnetic separation device 21', so that the two devices can be overlapped in the sample analyzer along the space in the second direction, and compared with the arrangement mode that the two devices are located at the same height, the transverse volume of the sample analyzer can be further reduced, and the longitudinal space of the sample analyzer can be fully utilized.

Referring to fig. 4 and 5, fig. 4 is a schematic structural diagram of a magnetic separation device according to an embodiment of the present application. Fig. 5 is a schematic structural diagram of a first implementation manner of a magnetic member layout according to an embodiment of the present application.

In the present embodiment, the magnetic separation apparatus includes a base 10, a turntable 11, and a magnetic member 12.

The base 10 is provided with a receiving groove.

The rotating disc 11 is rotatably disposed in the accommodating groove, and the rotating disc 11 is provided with at least one accommodating hole a for accommodating a sample container b containing a sample and/or a magnetic composite.

Alternatively, the turntable 11 is cylindrical, and each receiving hole a is equidistant from the axis of rotation of the turntable 11. The receiving hole a is provided adjacent to an edge position of the turntable 11, i.e., in an edge area of the turntable 11. The edge region refers to a position closer to the edge of the turntable 11 with respect to the center of the turntable 11 and the edge of the turntable 11. In this way, on the one hand, more accommodating holes a can be arranged on the same-size turntable 11 to accommodate the sample containers b; on the other hand, the accommodating hole a can be closer to the magnetic member 12 on the base 10, so as to improve the adsorption effect of the magnetic member 12 on the magnetic compound. The plurality of receiving holes a may be annularly distributed and equally spaced apart.

The magnetic member 12 is disposed on the base 10, and is used for adsorbing the magnetic compound in the sample container b to the inner wall of the sample container b.

The magnetic compound can comprise a magnetic sphere, an antigen or an antibody positioned on the surface of the magnetic sphere, and an analyte in blood combined with the antigen or the antibody. The surface of the magnetic ball is modified to have a coating structure and also has a functional group, the functional group is combined with antigen or antibody, the antigen or antibody is combined with a substance to be detected in blood to gradually form a large immune complex, and the final immune complex (namely, a target detection substance) is obtained by magnetic separation, separation and cleaning and is sent into a flow chamber of a detection device along with sheath fluid to be detected. During magnetic separation and cleaning, the immune complex is adsorbed on the inner wall of the sample container, supernatant is sucked away, the immune complex adsorbed on the inner wall is released at a detection station, and the immune complex is sucked into a flow chamber of the detection device for optical detection.

It will be appreciated that the magnetic complex may be either a reaction substrate prior to reaction: for example, the capture antibody-coated magnetic bead mixture may be a magnetic bead target detection substance formed after the reaction. In addition, it will be appreciated that the sample container may contain, in addition to the sample and/or magnetic complexes, other substances involved in the reaction, such as: reagents, ligands, diluents, and the like.

Optionally, at least one detection station J is disposed on the base 10, and the detection station J is nonmagnetic or can be controlled to be nonmagnetic, so that when the sample container b rotates to the detection station J along with the turntable 11, the detection device can conveniently suck the magnetic compound in the sample container b.

Alternatively, the inspection station J may also be controlled to be magnetic, so that magnetic separation and washing may also be performed at the inspection station J; that is, in this case, the detection station J can perform both the suction detection of the magnetic composite and the magnetic separation and cleaning. For example, the magnetic member 12 located at the detection station J is set to be a controllable magnetic member, and then magnetic separation or suction detection at the detection station J is realized by controlling the presence or absence of magnetism of the controllable magnetic member, and the controllable magnetic member may be an electromagnet. See in particular the description of the specific embodiments below.

Referring to fig. 6 in conjunction with fig. 4 and 5, fig. 6 is a schematic diagram illustrating a position relationship between a detecting device and a magnetic separating device according to an embodiment of the present disclosure. The sample suction needle 41 of the detection device 40 is movable or rotatable to the detection station J, and is extendable into the sample container b to suck the target detection object in the sample container b of the detection station J. Optionally, the magnetic separation device further includes a blending mechanism disposed at the detection station J, and the blending mechanism is configured to blend the magnetic compound and the liquid in the sample container b that rotates to the detection station J along with the turntable 11. Alternatively, the mixing mechanism may be the sample sucking needle 41 of the detection device 40. The detection device 40 controls the discharge or suction of the sample from the sample suction needle 41 to mix the sample, i.e., to suck and discharge the sample. Of course, in other embodiments, a blending mechanism may be separately disposed adjacent to the detection station J, and the embodiment of the present application is not limited to the manner of blending by using the sample suction needle 41 of the detection device 40. For example, the kneading mechanism is a stirring rod 42 provided in the detection device 40, and the sample is stirred and kneaded by the stirring rod 42.

Optionally, at least one pipetting station X is provided on the base 10, the magnetism generated by the magnetic member 12 being progressively increased from the detection station J to the pipetting station X.

The magnetic separation device can further comprise a first bracket 13, a light emitter 14, a light receiver 15, a shielding piece 16, a cleaning container 17, a liquid suction assembly 18, a liquid adding assembly 19, a support rod 20, a fixed connection seat 31 and a sample container detection assembly 32. Wherein the pipetting assembly 18 is positioned at the pipetting station X. The light emitter 14 and the light receiver 15 are both fixed on the base 10 through the first bracket 13, and the light emitter 14 and the light receiver 15 are oppositely arranged and spaced. The shielding member 16 is fixed on the turntable 11, and when the shielding member 16 rotates with the turntable 11 to a position corresponding to the light emitter 14 and the light receiver 15, the shielding member 16 is partially located between the light emitter 14 and the light receiver 15 to shield the light emitted by the light emitter 14 toward the light receiver 15.

For example, when the shielding member 16 rotates with the turntable 11 to a position corresponding to the light emitter 14 and the light receiver 15, the light emitted by the light emitter 14 toward the light receiver 15 is shielded by the shielding member 16, and the light emitted by the light emitter 14 cannot be received by the light receiver 15; when the shutter 16 is not in the position corresponding to the light emitter 14 and the light receiver 15, the light receiver 15 can receive the light emitted by the light emitter 14, so that the magnetic separation device can determine the initial position of rotation of the dial 11 by whether the light receiver 15 can receive the light emitted by the light emitter 14.

In this embodiment, the cleaning container 17 is fixed on the rotating disc 11 at a position corresponding to the shielding member 16 and is inserted into the avoiding hole of the shielding member 16. By arranging the cleaning container 17 at the position corresponding to the shielding piece 16, the magnetic separation device is compact in structure and convenient for miniaturization design, and by arranging the avoiding hole on the shielding piece 16, the cleaning container 17 is allowed to pass through to be exposed, so that the cleaning of the liquid suction assembly 18 or the liquid feeding assembly 19 is not influenced. In another embodiment, the cleaning vessel 17 can be fixed to the screen 16. By fixing the cleaning vessel 17 to the shutter 16, a structure for fixing the cleaning vessel 17 is not additionally provided, so that the structure of the magnetic separation apparatus is made relatively simple.

A pipetting assembly 18 is secured to the base 10 and is used to aspirate liquid in the sample container b which rotates with the turntable 11 to the position where the pipetting assembly 18 is located. Specifically, pipetting assembly 18 includes a second mount 181, a third mount 182, a pipette needle 183, and a wash needle 184. The second bracket 181 is fixed to the base 10, and the third bracket 182 is movably disposed on the second bracket 182 in a direction parallel to the rotation axis of the turntable 11 to approach or separate from the turntable 11. The pipette needle 183 and the wash needle 184 are fixed to the third frame 182, and the wash needle 184 is shorter than the pipette needle 183 so that the outer wall of the pipette needle 183 can be washed when the wash needle 184 discharges liquid.

Specifically, the length of the liquid suction needle 183 is greater than that of the cleaning needle 184, the liquid suction needle 183 and the cleaning needle 184 are fixed in relative position and are disposed to abut against each other, and the height of the liquid outlet of the cleaning needle 184 relative to the base 10 is greater than the height of the liquid suction port of the liquid suction needle 183 relative to the base 10.

When the sample container b rotates to the lower part of the liquid suction needle 183 and the cleaning needle 184 along with the turntable 11, the magnetic separation device controls the liquid suction needle 183 and the cleaning needle 184 to extend into the sample container b for liquid suction.

The cleaning vessel 17 is used to clean the pipetting module 18 when the pipetting module 18 is rotated with the turntable 11 to the position. Specifically, when the cleaning container 17 rotates to the position below the liquid suction needle 183 and the cleaning needle 184 along with the turntable 11, the magnetic separation device controls the liquid suction needle 183 and the cleaning needle 184 to move downwards and extend into the cleaning container 17, the cleaning needle 184 and the liquid suction needle 183 discharge liquid at the same time, the liquid discharged by the cleaning needle 184 cleans the outer wall of the liquid suction needle 183, and the liquid discharged by the liquid suction needle 183 cleans the inner wall of the liquid suction needle 183.

The priming assembly 19 is fixed to the base 10 and is used to inject liquid into the sample container b which rotates with the turntable 11 to the position where the priming assembly 19 is located. The injected liquid may be a reagent. The filling assembly 19 is located at a filling station T on the base 10. Optionally, the magnetism of the liquid adding station T is weaker than that of the liquid absorbing station X, and the magnetism of the liquid adding station T is stronger than that of the detection station J.

Optionally, the priming assembly 19 includes a fourth cradle 191, a fifth cradle 192, and a priming needle 193. The fourth bracket 191 is fixed to the base 10, and the fifth bracket 192 is movably disposed on the fourth bracket 191 in a direction parallel to the rotation axis of the turntable 11 to approach or separate from the turntable 11. The filling needle 193 is fixed to the fifth bracket 192. The fifth bracket 192 may be fixedly disposed on the fourth bracket 191, so that the filling needle 19 cannot move up and down, thereby saving the cost of designing a driving mechanism for moving up and down.

It should be understood that the filling needle 193 may be fixedly disposed with respect to the base 10 so as not to move up and down, and the cleaning container 17 may be used only for cleaning the pipette needle 183.

In another embodiment, when the sample container b rotates with the turntable 11 to a position below the liquid adding needle 193, the magnetic separation device controls the liquid adding needle 193 to move downwards to extend into the sample container b, and then the liquid adding needle 193 discharges liquid to add liquid into the sample container b.

The cleaning vessel 17 is further used to clean the refill unit 19 when it is rotated with the turntable 11 to the position of the refill unit 19. Specifically, when the cleaning container 17 rotates with the turntable 11 to a position below the liquid feeding needle 193, the magnetic separation device controls the liquid feeding needle 193 to move downward, and the liquid feeding needle 193 is inserted into the cleaning container 17 to be cleaned.

The fixed connection holder 31 is connected to the base 10 through the support bar 20. Alternatively, the number of the support rods 20 is four. In other embodiments, the number of the support rods 20 may be three. The fixed connection seat 31 is used for fixing with other structures.

The sample container testing assembly 32 includes a sixth rack 321 and a test sensor 322 disposed on the sixth rack 321. The detection sensor 322 is configured to detect whether or not a sample container b is placed in a certain receiving hole b when the receiving hole b is rotated to a position corresponding to the detection sensor 322. Alternatively, the detection sensor may be an optical coupler, and specifically may be a reflective optical coupler.

An embodiment of the first detection station and the first magnetic member layout will be described with reference to fig. 5, 7, and 8.

Fig. 7 is a schematic top view of a first embodiment of a magnetic element layout according to the present application. Fig. 8 is a schematic diagram of a positional relationship among the magnetic member, the turntable, and the accommodating hole according to the first embodiment of the magnetic member layout of the present application.

In the first embodiment, the magnetic member 12 is provided on the base 10. The number of the magnetic members 12 is multiple, and the magnetic members 12 correspond to the number of the accommodating holes one by one. At least one magnetic member 12(a) of the plurality of magnetic members 12 is a controllable magnetic member, and the remaining magnetic members 12 are permanent magnets, and the controllable magnetic member is disposed at the detection station J.

Optionally, one magnetic member 12(a) of the plurality of magnetic members 12 is a controllable magnetic member, and the remaining magnetic members 12 are permanent magnets; correspondingly, the number of the detection stations J is one, and the controllable magnetic part is positioned at the detection stations J.

It should be understood that a plurality of detection stations J may be provided, and when the number of detection stations J is plural, the magnetic member 12(a) of each detection station J is designed as a controllable magnetic member. When the number of the detection stations J is designed to be plural, the detection efficiency of the target detection object in the sample container b on the rotary table 11 can be improved.

When a certain sample container b rotates to the position where the controllable magnetic member is located (i.e. the detection station J), the magnetic separation device generates a magnetic field by controlling the controllable magnetic member so that the magnetic complex is adsorbed on the inner wall of the sample container b to perform magnetic separation, and/or the controllable magnetic member is controlled not to generate magnetism so that the detection device J can absorb the magnetic complex in the sample container.

For example, the controllable magnetic member is an electromagnet, and the magnetic separation device controls the presence or absence of magnetism of the electromagnet by energizing or de-energizing the electromagnet. Specifically, for example, the electromagnet generates magnetism when energized, and the electromagnet does not generate magnetism when not energized. It should be understood that the controllable magnetic member is not limited to the case of using an electromagnet, and other controllable magnetic members that can be selectively controlled to be magnetic or non-magnetic are also within the scope of the present application.

In this embodiment, the first specific way of increasing the magnetism generated by the magnetic member 12 from the detection station J to the liquid suction station X is: the area of the surface of each magnetic member 12 close to one side of the rotary table 11 from the detection station J to the liquid suction station X is gradually increased; the second specific implementation mode is as follows: the thickness of each magnetic member 12 gradually increases from the inspection station J to the pipetting station X. It will be appreciated that in other embodiments, the gradual increase in magnetism from the detection station J to the pipetting station X can also be achieved in combination with the first and second implementations, for example, the respective magnetic members 12 increase in area and thickness from the detection station J to the pipetting station X.

Alternatively, the magnetic member 12 is disposed adjacent to an edge of the turntable 11, the base 10 is provided with a first notch q1 at a position corresponding to the magnetic member 12, and the magnetic member 12 is exposed toward the turntable 11 through the first notch q 1. In this way, the magnetic member 12 is exposed toward the side of the rotation axis of the turntable 11, and the adsorption effect of the magnetic member 12 on the magnetic complex in the sample container b is increased.

Alternatively, the turntable 11 is provided with a second notch q2 at a position corresponding to the receiving hole a, and the sample container b placed in the receiving hole a is exposed to the base 10 through the second notch q 2.

In this way, the sample container b placed in the accommodating hole a is exposed to the base 10 through the second notch q2, so as to increase the adsorption effect of the magnetic member 12 on the magnetic compound in the sample container b.

As shown in fig. 8, the surface of the magnetic member 12 close to the receiving hole a is a plane, the receiving hole a is a circular hole, and the surface of the magnetic member 12 close to the receiving hole a is perpendicular to a reference plane ABCD defined by the rotation axis AB of the turntable 11 and the axis CD of the receiving hole a.

Optionally, the length of the magnetic member 12 is equal to the depth of the receiving hole a, so that the inner wall of the portion of the sample container b located in the receiving hole a can adsorb magnetic compounds at different positions in the height direction, thereby improving the adsorption efficiency. The upper end of the magnetic member 12 may be flush with the upper end of the receiving hole a, and the lower end of the magnetic member 12 may be flush with the bottom of the receiving hole a.

Alternatively, the shape of the magnetic member 12 may be a rectangular parallelepiped, i.e., each surface of the magnetic member 12 is a plane. In other embodiments, only the surface of the magnetic member 12 near the accommodating hole a may be provided as a flat surface.

Because the shape of the magnetic part 12 is a cuboid, and the shape of the used magnetic part 12 is a plate type, the processing difficulty is small, the cost can be effectively reduced, and the required effect can be achieved.

Please refer to fig. 9, fig. 9 is a schematic view illustrating a magnetic attraction principle of the magnetic element according to the first layout manner of the present application. Alternatively, one of the two ends of the magnetic member 12 in the direction of the rotation axis of the turntable 11 is an S pole, and the other is an N pole. Through the above manner, the magnetic compound Q in the sample container b can be adsorbed on two lines at two positions on the inner wall of the sample container b corresponding to the two ends of the magnetic member 12 along the direction of the rotation axis of the turntable 11. For example, as shown in the figure, the magnetic composite Q is adsorbed on the inner wall of the sample container b and corresponds to two lines at the upper and lower ends of the magnetic member 12.

In other embodiments, the magnetic member 12 may have magnetism only at both end portions in the direction of the rotation axis of the turntable 11, and the middle portion between the both end portions may not have magnetism, and of the both end portions, one of a side close to the accommodation hole a corresponding to the magnetic member 12 and a side far from the accommodation hole a corresponding to the magnetic member 12 is an S pole, and the other is an N pole, so that the magnetic compound Q is adsorbed on the inner wall of the sample container b in a concentrated manner and corresponds to the positions of the both end portions.

An embodiment of the second inspection station is described below with reference to fig. 10. Fig. 10 is a schematic structural view of a push-pull mechanism according to an embodiment of the present application. The second embodiment of the detection station is also realized in the first magnetic member layout mode.

In the second embodiment, the magnetic member 12 is provided on the base 10. The number of the magnetic members 12 is plural, and the plural magnetic members 12 correspond to the number of the accommodation holes a one by one. Each of the plurality of magnetic members 12 is a permanent magnet. The magnetic member 12(a) at the detection station J is removably disposed in the corresponding mounting hole of the base, and other magnetic members 12 not at the detection station J may be fixed in the corresponding mounting holes of the base 10.

It should be understood that the number of the detection stations J may be multiple, and when the number of the detection stations J is multiple, the magnetic members 12 at the multiple detection stations J are all detachably disposed in the corresponding mounting holes on the base 10.

The magnetic separation device further comprises a push-pull mechanism 21, wherein the push-pull mechanism 21 is used for drawing the magnetic part 12(a) positioned at the detection station J away from the mounting hole when the sample container b rotates to the detection station J along with the rotary disc 11 so as to facilitate the detection device 40 to suck the magnetic compound in the sample container b; alternatively, the magnetic member 12(a) is pushed into the mounting hole before the sample container b is rotated with the turntable 11 to the pipetting station X to adsorb the magnetic composite.

Alternatively, the push-pull mechanism 21 includes a fixed substrate 211 fixed to the base 10, a slider 212 slidably disposed on the fixed substrate 211, a push plate 213 fixed to the slider 212, and a power mechanism 214 for driving the slider 212 to slide relative to the fixed substrate 211, where the push plate 213 is connected to the magnetic member 12(a), and the power mechanism 214 drives the push plate 213 to move when the slider 212 slides relative to the fixed substrate 211, so as to push the magnetic member 12(a) into the mounting hole on the base 10 or pull the magnetic member 12(a) out of the mounting hole on the base 10.

Optionally, the power mechanism 214 includes a motor 214a fixed on the fixed base plate 211, a driving wheel 214b disposed on a rotation shaft of the motor 214a, a driven wheel 214c rotatably disposed on the fixed base plate 211, and a transmission belt 214d sleeved on the driving wheel 214b and the driven wheel 214c, wherein the transmission belt 214d is fixed to the slider 212 at one position along the length direction. The drive belt 214d may be a timing belt.

Alternatively, the pushing plate 213 includes a first connecting plate 213a and a second connecting plate 213b connected to the first connecting plate 213a in a bent manner, the first connecting plate 213a is fixed to the slider 212, and the second connecting plate 213b is connected to the magnetic member 12 (a).

Optionally, the push-pull mechanism 21 further includes a slide rail 215, the slide rail 215 is disposed on the fixed substrate 211, and the slider 212 is slidably disposed on the fixed substrate 211 through the slide rail 215.

It should be understood that, in other embodiments, the push-pull mechanism may have other structures as long as the magnetic member 12(a) can be pulled out from the mounting hole and the magnetic member 12(a) can be pushed into the mounting hole.

An embodiment of the third inspection station is described below in conjunction with fig. 12. Fig. 12 is a schematic structural diagram of an implementation of the third inspection station of the present application. In the third inspection station J, the magnetic members 12 are arranged in a manner similar to the first arrangement. The difference is that the detection station J is vacant and is not provided with any magnetic member 12, namely the detection station J has no magnetism.

In the third embodiment of the inspection station, the number of the magnetic members 12 is plural, and each of the magnetic members 12 may be a permanent magnet. The number of the magnetic members 12 is less than that of the accommodating holes a, a first spacing between at least one set of two adjacent magnetic members 12(b) and 12(c) is greater than a second spacing between any other two adjacent magnetic members 12, a difference between the first spacing and the second spacing is greater than or equal to a width of one magnetic member 12, and the detection station J is located between at least one set of two adjacent magnetic members 12(b) and 12 (c). In other words, no magnetic member is disposed at the inspection station J, i.e., the two magnetic members 12(b) and 12(c) adjacent to each other on both sides of the inspection station J are spaced apart by at least the width of one magnetic member 12.

An embodiment of the fourth inspection station and the second magnetic member layout will be described with reference to fig. 13 and 14. FIG. 14 is a schematic structural diagram of an embodiment of a fourth inspection station in an embodiment of the present application. Fig. 13 is a schematic structural diagram of magnetic members in a second magnetic member layout manner according to an embodiment of the present application.

The fourth embodiment of this application detection station is based on the overall arrangement mode of second kind magnetic member, and in the overall arrangement mode of second kind magnetic member, magnetic member 22 is one in quantity, and magnetic member 22 is the annular and encircles the periphery at carousel 11.

As described above, the magnetic member 22 is disposed on the base 10. As shown in fig. 9, in the present embodiment, the magnetic member 22 is fixed to the side wall of the receiving groove in the base 10. In other embodiments, the base may be provided with an annular groove, and the magnetic member is embedded in the annular groove. The base is provided with a notch corresponding to the accommodating hole, and the magnetic part is exposed towards the turntable through the notch.

The fourth detection station of the present application is implemented as follows: the annular magnetic member 22 has a notch 221 at the position of the inspection station J.

Alternatively, one of the two ends of the magnetic member 22 in the direction of the rotation axis of the turntable 11 is an S pole, and the other is an N pole. In this way, the magnetic composite in the sample container b can be adsorbed on a line (a bus closest to the magnetic member 22 when the sidewall of the sample container b is a cylindrical surface) closest to the inner wall of the magnetic member 22, and further, the magnetic composite is most densely distributed at the upper and lower ends of the sample container b.

Alternatively, the size of the magnetic member 22 in the direction of the rotation axis of the turntable 11 from the inspection station J to the pipetting station X gradually increases, in other words, the magnetic attracting area of the magnetic member 22 from the inspection station J to the pipetting station X gradually increases, so that the magnetism generated from the inspection station J to the pipetting station X magnetic member 22 gradually increases. In other embodiments, a gradual increase in thickness of the magnetic member 12 from the inspection station J to the pipetting station X may be provided, so that a gradual increase in magnetic properties may also be achieved. It should be understood that the magnetic property may be gradually enhanced by combining the thickness and the magnetic attraction area, and the magnetic property may also be gradually enhanced by combining the material of the magnetic member, for example, by the difference of the magnetic property of the material adopted by the magnetic member.

An embodiment of the fifth inspection station is described below with reference to fig. 14. The fifth detection station can be realized based on the layout mode of the first magnetic member or the layout mode of the second magnetic member.

Referring to fig. 14, fig. 14 is a schematic structural diagram of a fifth detection station according to an embodiment of the present application.

In a fifth embodiment of the inspection station, the magnetic member 12 is disposed on the base 10. The number of the magnetic members 12 is plural, and the number of the magnetic members 12 corresponds to the number of the accommodation holes a one-to-one. The plurality of magnetic members 12 may be all permanent magnets, and the rotary plate 11 is further provided with a sensing position accommodating hole a1, and the layout of the magnetic members 12 is similar to the first layout. In the present embodiment, the turntable 11 is provided with a detection position accommodating hole a 1. The distance from the receiving hole a1 to the center of the turntable 11 is smaller than the distance from the receiving hole a to the center of the turntable 11, so that the distance from the receiving hole a1 to the magnetic member 12 is relatively longer than the distance from the receiving hole a to the magnetic member 12, and the magnetic force of the magnetic member 12 received by the receiving hole a1 is smaller, so that after the sample container b is transferred from the receiving hole a to the receiving hole a1, the magnetic compound adsorbed on the sidewall of the sample container b slides down to the bottom of the sample container b, so that the magnetic compound can be easily absorbed by the detection device 40. Alternatively, the detection bit accommodating hole a1 is provided at a central position of the dial 11.

It should be understood that the fifth detection station can also be implemented in the second magnetic member layout. In the case where the magnetic member 22 is formed in a ring shape and is disposed around the turntable 11, the same applies to the manner in which the detection position accommodating hole a1 is provided in the turntable 11.

Alternatively, in this embodiment mode, the magnetic separation apparatus may further include a grasping and transferring device for grasping and transferring the sample container b between the accommodating hole a and the detection site accommodating hole a 1.

Referring to fig. 15, fig. 15 is a schematic structural diagram of a sixth inspection station according to an embodiment of the present application.

The sixth embodiment of the inspection station is based on a third arrangement of magnetic elements, in which the magnetic elements 52 are arranged on the turntable 11. The number of the magnetic members 52 is plural, and the plural magnetic members 52 correspond to the number of the accommodation holes a one by one. The magnetic member 52 is annular and disposed in the accommodating hole a and around the sample container b.

Through the mode, the magnetic piece 52 is arranged to surround the sample container b, so that the magnetic compound can be adsorbed everywhere on the inner side wall of the sample container b, and the adsorption effect of the magnetic compound is improved. Further, the magnetic part 12 with the circular ring-shaped cross section is arranged to surround the sample container b, so that the magnetic compounds adsorbed on the inner side wall of the sample container b are uniformly distributed, each magnetic compound can be subjected to uniform magnetic force, and the loss of the magnetic compounds caused in the liquid suction process is reduced.

Referring to fig. 16 in conjunction with fig. 15, fig. 16 is a schematic view illustrating a magnetic attraction principle in a third magnetic element layout manner of the present application.

Alternatively, one of the two ends of the magnetic member 52 in the direction of the rotation axis of the turntable 11 is an S pole, and the other end is an N pole. The magnetic composite Q can be caused to concentrate on two lines (two dotted lines as shown in the figure) on the inner wall of the sample container b corresponding to the positions of both ends of the magnetic member in the direction of the rotation axis of the turntable 11 (for example, the upper and lower ends of the magnetic member as shown in the figure).

In this embodiment, the arrangement of the withdrawing mechanism is similar to that of the above embodiment, and specific reference is made to the structure of the withdrawing mechanism. See in particular the structure of the above-mentioned pull-off mechanism.

There are two detection station implementation manners based on the third magnetic member layout manner. The first detection station implementation mode of the third magnetic part layout mode is as follows: the magnetic pieces 52 are controllable magnetic pieces 52, and when the sample container b rotates to the detection station J along with the turntable 11, the magnetic separation device controls the magnetic piece 52(a) corresponding to the sample container b not to generate magnetism, so that the detection device 40 can suck the magnetic compound conveniently; and/or, the magnetic separation device controls the magnetic member 52(a) to generate magnetism so that the magnetic complex is adsorbed on the inner wall of the sample container b to perform magnetic separation.

The second detection station implementation mode of the third magnetic part layout mode is as follows: the magnetic separation device further comprises a push-pull mechanism, and the push-pull mechanism is used for pulling the magnetic part corresponding to the sample container b away from the rotary table 11 when the sample container b rotates to the detection station J along with the rotary table 11 so as to facilitate the detection device 40 to absorb the magnetic compound in the sample container b; alternatively, the corresponding magnetic member 52 is pushed into the rotary disk 11 to adsorb the magnetic composite before the sample container c is rotated with the rotary disk to the pipetting station X. The specific structure of the push-pull mechanism can be referred to the above description, and is not described herein again.

Referring to fig. 17, fig. 17 is a schematic structural diagram of a seventh inspection station according to an embodiment of the present application.

The seventh embodiment of the inspection station is based on a fourth arrangement of magnetic members in which the magnetic members 62 are provided on the turntable 11. The magnetic member 62 is disposed at one side of the corresponding receiving hole a and is fixedly embedded on the rotating disc 11.

Each of the receiving holes a is adapted to receive a corresponding one of the sample containers b containing a sample and/or a magnetic composite, so that the magnetic composite in the sample container b adheres to the inner wall of the sample container b by the attraction of the magnetic member 62.

Since the magnetic composite in each sample container b will be attracted to the attraction direction of the magnetic member 62 disposed in the sample container b, and the relative positions of the magnetic members 62 with respect to the corresponding sample container b are the same, the attraction force of the magnetic composite in the sample container b by the two adjacent magnetic members 62 is also in the similar direction of the attraction force of the magnetic member 62 disposed in the sample container b, so that the attraction effect of the magnetic composite can be improved.

Since the magnetic member 62 is fixed to the rotation disk 11, the magnetic member 62 rotates with the rotation disk 11, and when the rotation disk 11 rotates, the relative positions of the magnetic member 62 to the accommodating hole a and the sample container b do not change, and the direction of the attraction force of the magnetic member 62 to the magnetic compound does not change. The adsorption can be carried out while the rotary table 11 rotates, and the working efficiency and the adsorption efficiency of the magnetic separation can be improved.

The surface of the magnetic member 62 close to the receiving hole a is a plane, the surface of the receiving hole a is a circular hole, and the surface of the magnetic member 62 close to the receiving hole a is perpendicular to a reference plane determined by the rotation axis of the turntable 11 and the axis of the receiving hole a.

Optionally, the length of the magnetic member 62 is equal to the depth of the receiving hole a, so that the inner wall of the portion of the sample container b located in the receiving hole a can adsorb the magnetic compound at different positions in the height direction, thereby improving the adsorption efficiency. For example, the upper end of the magnetic member 62 may be flush with the upper end of the receiving hole a, and the lower end of the magnetic member 62 may be flush with the bottom of the receiving hole a.

Alternatively, the magnetic member 62 is shaped as a rectangular parallelepiped, i.e., each surface of the magnetic member 62 is a plane. In other embodiments, only the surface of the magnetic member 62 near the accommodating hole a may be provided as a flat surface.

Because the shape of magnetic part 62 is the cuboid, the shape of the magnetic part 62 who uses is the board type, and the processing degree of difficulty is little, can effectively reduce cost, can reach required effect again.

Alternatively, the surface of the magnetic member 62 close to the receiving hole a is spaced from the receiving hole a without direct contact, and the magnetic member 62 is embedded in the rotating disk 11. Since the magnetic member 62 is placed at a place not in contact with the sample container b, the magnetic member 62 is prevented from being corroded by the liquid that may be scattered during pipetting, and the magnetic loss of the magnetic member 62 is reduced.

In the present embodiment, the magnetic members 62 are disposed at the side of the corresponding accommodation hole a close to the rotation axis of the turntable 11. In this way, the receiving hole a can be designed closer to the edge of the turntable 11, and more receiving holes a can be arranged under the condition that the size of the turntable 11 is fixed.

In other embodiments, the magnetic member 62 may be disposed at a side of the corresponding accommodating hole a away from the rotation axis of the turntable 11, which is not limited in the embodiments of the present application.

There are two detection station implementation manners based on the fourth magnetic member layout manner. The first detection station implementation mode of the fourth magnetic part layout mode is as follows: the magnetic pieces 62 are controllable magnetic pieces 62, and when the sample container b rotates to the detection station J along with the turntable 11, the magnetic separation device controls the magnetic piece 62(a) corresponding to the sample container b not to generate magnetism, so that the detection device 40 can suck the magnetic compound conveniently; and/or, the magnetic separation device controls the magnetic member 62(a) to generate magnetism so that the magnetic compound is adsorbed on the inner wall of the sample container b to perform magnetic separation.

The second detection station implementation mode of the fourth magnetic part layout mode is as follows: the magnetic pieces are detachably arranged on the turntable 11, and the magnetic separation device further comprises a push-pull mechanism for pulling the magnetic piece 62 corresponding to the sample container b away from the turntable 11 when the sample container b rotates to the detection station J along with the turntable 11 so as to facilitate the detection device 40 to absorb the magnetic compound in the sample container b; alternatively, the corresponding magnetic member 62 is pushed into the turntable 11 to adsorb the magnetic composite before the sample container c is rotated with the turntable to the pipetting station X. The specific structure of the push-pull mechanism can be referred to the above description, and is not described herein again.

It should be understood that the first base 211' in the above embodiments may refer to the susceptor 10. The first turntable 212' may be referred to as turntable 11. The sample container c' may refer to the sample container b. The first receiving hole a' may refer to the receiving hole a, but similar names and different reference numerals are used in different embodiments.

The sample analyzer of the present embodiment includes the magnetic separation device described in the above-described embodiment.

The flow-type fluoroimmunoassay analyzer of an embodiment of the present application includes a detection device and the magnetic separation device of any one of the above embodiments, the detection device including a flow cell, the detection device being configured to draw a target analyte in a sample container of the magnetic separation device into the flow cell for optical detection.

Referring to fig. 18, fig. 18 is a schematic flowchart illustrating a control method of a sample analyzer according to a first embodiment of the present application.

In this embodiment, the control method of the sample analyzer may include the steps of:

step S101: and controlling the grabbing and releasing device to move on the first guide piece along the first direction to a position corresponding to one of the at least two processing devices.

Step S102: and controlling the grabbing and releasing device to grab the sample container at the processing device.

Step S103: and controlling the pick-and-place device to move on the first guide piece along the first direction to a position corresponding to the other processing device of the at least two processing devices.

Step S104: the pick-and-place device is controlled to release the sample container to place the sample container at another processing device.

Optionally, the at least two processing devices comprise a magnetic separation device for performing a magnetic separation process on the sample in the sample container and an incubation device for performing an incubation process on the sample in the sample container.

For example, in one embodiment, the pick and place device transfers the sample container from the incubation device to the magnetic separation device.

Step S101 may specifically be: after the incubation device finishes incubating the samples in the sample containers, the grasping and placing device is controlled to move on the first guide piece along the first direction to the corresponding position of the incubation device.

Step S102 may specifically be: and controlling the grabbing and releasing device to grab the sample container at the incubation device.

Step S103 may specifically be: and controlling the grabbing and releasing device to move on the first guide piece along the first direction to a position corresponding to the magnetic separation device.

Step S104 may specifically be: and controlling the grabbing and placing device to release the sample container so as to place the sample container at the magnetic separation device.

Optionally, the at least two processing devices further comprise a container retrieval device for receiving used sample containers.

For example, in another embodiment, the pick and place device transfers the discarded sample container from the magnetic separation device to the container reclamation device.

Step S101 may specifically be: after the detection device finishes sucking the sample in the sample container, the grabbing and releasing device is controlled to move on the first guide piece along the first direction to the position corresponding to the magnetic separation device.

Step S102 may specifically be: and controlling the grabbing and releasing device to grab the sample container at the magnetic separation device.

Step S103 may specifically be: and controlling the grabbing and placing device to move on the first guide piece along the first direction to a position corresponding to the container recovery device.

Step S104 may specifically be: and controlling the grabbing and placing device to release the sample container so as to place the sample container at the container recovery device.

It should be understood that the transfer of the sample container between any two processing devices may be performed, and the above is merely illustrative of two cases, and other cases are not listed here.

This application embodiment includes through setting up sample analyzer: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing the sample contained in the sample container or recycling the sample container; the first guide piece is fixed relative to the base; and the grabbing and releasing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and releases the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device. Because grab and put the device and set up on first guide with removing along first direction to the length direction motion along first guide, so grab and put the shared space of device motion little, can reduce the whole volume of instrument, the miniaturized design of the instrument of being convenient for, and can improve work efficiency.

The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure or those directly or indirectly applied to other related technical fields are intended to be included in the scope of the present disclosure.

Claims

1. A sample analyzer, comprising:

a base;

the at least two processing devices are directly or indirectly arranged on the base and are used for placing a sample container and processing a sample contained in the sample container or recycling the sample container;

the relative position of the first guide piece and the base is fixed;

a pick and place device movably disposed on the first guide in a first direction, the pick and place device picking up a sample container at one of the at least two processing devices after moving to a position corresponding to the one of the at least two processing devices in the first direction and releasing the sample container to place the sample container at the other of the at least two processing devices after moving to a position corresponding to the other of the at least two processing devices in the first direction.

2. The sample analyzer of claim 1, wherein the at least two processing devices comprise a magnetic separation device for performing a magnetic separation process on the sample in the sample container and an incubation device for performing an incubation process on the sample in the sample container.

3. The sample analyzer of claim 2 wherein the at least two processing devices further comprise a container retrieval device for receiving used sample containers.

4. The sample analyzer of claim 2, further comprising a first retaining plate, wherein the first guide is relatively fixed to the base by the first retaining plate.

5. The sample analyzer of claim 1 further comprising a second retaining plate movably disposed on the first guide in the first direction, the pick-and-place device being coupled to the second retaining plate.

6. The sample analyzer of claim 1, further comprising a second guide member fixed to the second fixing plate, wherein the grasping and releasing device is movably disposed on the second guide member in a second direction, and wherein the first direction intersects the second direction.

7. The sample analyzer of claim 6, wherein the first direction is perpendicular to the second direction.

8. The sample analyzer of claim 4 further comprising a container adding device for adding a sample container to the incubation device, the container adding device having a height relative to the base that is greater than a height of the incubation device relative to the base, the fixed position of the first fixing plate being higher than the incubation device and higher than the magnetic separation device.

9. The sample analyzer as claimed in claim 8, wherein the container adding means comprises at least a magazine and a container passage, the sample container in the magazine is transported to the incubating means through the container passage, the container passage comprises a chute and an adjusting plate, the chute is disposed obliquely with respect to the bottom surface of the base, and the adjusting plate is provided with a plurality of placement holes, and the axial direction of the placement holes is perpendicular to the bottom wall of the chute.

10. The sample analyzer of claim 5 wherein the incubation device places a sample container at a different height relative to the base than the magnetic separation device places a sample container at a different height relative to the base.

11. The sample analyzer of claim 10 wherein the height of the incubation device relative to the base at which the sample container is positioned is greater than the height of the magnetic separation device relative to the base at which the sample container is positioned.

12. The sample analyzer as claimed in claim 3, wherein the magnetic separation device comprises a first base and a first rotary disc rotatably connected to the first base, the first rotary disc is provided with at least one first receiving hole, the incubation device comprises a second base and a second rotary disc rotatably connected to the second base, the second rotary disc is provided with at least one second receiving hole, the container recovery device has a receiving channel, and the predetermined first receiving hole and the predetermined second receiving hole are located at corresponding positions of the first guide by rotating the first rotary disc and the second rotary disc, and the predetermined first receiving hole, the predetermined second receiving hole and the receiving channel are located on a straight line, so that the holding and releasing device can be positioned at the predetermined first receiving hole, the predetermined second receiving hole, The receiving channels transfer sample containers therebetween.

13. A method of controlling a sample analyzer, the method comprising:

controlling the grabbing and releasing device to move on the first guide piece along a first direction to a position corresponding to one of the at least two processing devices;

controlling the pick-and-place device to pick up a sample container at the processing device;

controlling the pick-and-place device to move on the first guide piece along the first direction to a position corresponding to the other processing device of the at least two processing devices;

controlling the pick-and-place device to release the sample container to place the sample container at the other processing device.

14. The control method according to claim 13, wherein the at least two processing devices comprise a magnetic separation device for performing a magnetic separation process on the sample in the sample container and an incubation device for performing an incubation process on the sample in the sample container.

15. The control method of claim 14, wherein the at least two processing devices further comprise a container recovery device for receiving used sample containers.