CN111381057B

CN111381057B - Sample analyzer and control method thereof

Info

Publication number: CN111381057B
Application number: CN201811642386.0A
Authority: CN
Inventors: 王锐; 周宇航; 刘治志
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2018-12-29
Filing date: 2018-12-29
Publication date: 2024-03-12
Anticipated expiration: 2038-12-29
Also published as: CN111381057A

Abstract

A sample analyzer and a control method thereof. The application discloses a sample analyzer, this sample analyzer includes: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing samples contained in the sample container or recycling the sample container; the first guide piece is fixed with the relative position of the base; and the grabbing and placing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and loosens the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device. Through the mode, the sample analyzer can be conveniently miniaturized under the condition that normal use of the sample analyzer is not affected, and the working efficiency is improved.

Description

Sample analyzer and control method thereof

Technical Field

The invention relates to the technical field of medical equipment, in particular to a sample analyzer and a control method thereof.

Background

Currently, in sample analyzers, movement of the sample container between the incubation plate, magnetic separation, gripper, and cuvette channel is performed by a mechanical swing arm. The track of mechanical cantilever motion is circular orbit, and this just requires incubation dish, magnetic separation and useless cup passageway's spatial layout to be on same horizontal plane, and can no longer overall arrangement other parts on cantilever motion space to satisfy cantilever swing required space, thereby lead to sample analysis appearance's volume great, be inconvenient for the transport and can occupy great space of placing, in addition, mechanical swing arm's work efficiency is lower.

Disclosure of Invention

The technical problem that this application mainly solves is to provide a sample analysis appearance and control method thereof, can be under the condition that does not influence sample analysis appearance normal use, the miniaturized design of sample analysis appearance of being convenient for, and can improve work efficiency.

In order to solve the technical problems, a technical scheme adopted by the embodiment of the application is as follows: providing a sample analyzer comprising: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing samples contained in the sample container or recycling the sample container; the first guide piece is fixed with the relative position of the base; and the grabbing and placing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and loosens the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device.

In order to solve the technical problems, another technical scheme adopted in the embodiment of the application is as follows: provided is a control method of a sample analyzer, the control method including: controlling the grabbing and placing device to move to a corresponding position of one of the at least two processing devices along a first direction on the first guide piece; controlling the grabbing and placing device to grab the sample container at the processing device; controlling the grabbing and placing device to move to the corresponding position of the other processing device in the at least two processing devices along the first direction on the first guide piece; the control catch and release device releases the sample container to place the sample container at another processing device.

The embodiment of the application comprises the following steps of: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing samples contained in the sample container or recycling the sample container; the first guide piece is fixed with the relative position of the base; and the grabbing and placing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and loosens the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device. The grabbing and placing device is movably arranged on the first guide piece along the first direction and moves along the length direction of the first guide piece, so that the space occupied by the grabbing and placing device in movement is small, and the miniaturization design of the sample analyzer can be facilitated under the condition that the normal use of the sample analyzer is not affected; in addition, the grabbing and placing device moves on the first guide piece, and therefore working efficiency is higher.

Drawings

FIG. 1 is a schematic perspective view of a sample analyzer according to an embodiment of the present application;

FIG. 2 is another perspective view of a sample analyzer according to an embodiment of the present application;

fig. 3 is a schematic structural view of a second turntable of the incubation apparatus of the embodiments of the present application.

FIG. 4 is a schematic view of the structure of a magnetic separation device according to an embodiment of the present application;

FIG. 5 is a schematic diagram of a first implementation of a magnetic element layout according to an embodiment of the present application;

FIG. 6 is a schematic diagram of the positional relationship of a detection device and a magnetic separation device according to an embodiment of the present application;

FIG. 7 is a schematic top view of a first embodiment of a magnetic article layout of the present application;

FIG. 8 is a schematic diagram showing the positional relationship among the magnetic member, turntable, and receiving hole in the first embodiment of the magnetic member layout of the present application;

FIG. 9 is a schematic diagram of the magnetic attraction principle of the first layout mode of the magnetic member of the present application;

FIG. 10 is a schematic diagram of a push-pull mechanism according to an embodiment of the present application;

FIG. 11 is a schematic illustration of an implementation of a third inspection station of the present application;

FIG. 12 is a schematic view of a fourth exemplary inspection station implementation;

FIG. 13 is a schematic diagram of a magnetic element in a second magnetic element layout according to an embodiment of the present disclosure;

FIG. 14 is a schematic view of a fifth inspection station implementation of the present example;

FIG. 15 is a schematic view of a sixth exemplary inspection station implementation;

FIG. 16 is a schematic diagram of the magnetic attraction principle in the third magnetic member layout mode of the present application;

FIG. 17 is a schematic view of a seventh inspection station implementation in accordance with an embodiment of the present application;

fig. 18 is a flow chart of a first embodiment of a control method of the sample analyzer of the present application.

Detailed Description

Referring to fig. 1 and 2, fig. 1 is a schematic perspective view of a sample analyzer according to an embodiment of the present application, and fig. 2 is another schematic perspective view of a sample analyzer according to an embodiment of the present application.

In this embodiment, the sample analyzer may include: a base 10 ', at least two treatment devices 21', 22 ', 23', a first guide 30 'and a pick-and-place device 40'.

The base 10 'is placed on the work surface, and the lower surface of the base 10' is in contact with the work surface. The following description of the orientation, such as "above", "below", "upper surface", "lower surface", etc., is based on the lower surface of the base 10'.

The treatment device 21 ', the treatment device 22' and the treatment device 23 'are all disposed directly or indirectly on the upper surface of the base 10'.

The processing device 21 ', the processing device 22', or the processing device 23 'is used for placing the sample container c' and processing the sample contained in the sample container c 'or for recycling the sample container c'.

The pick-and-place device 40 'is movably disposed on the first guide 30' in a first direction.

The pick-and-place device 40 'is used to pick or release the sample container c' to transfer the sample container c 'between any two of the processing device 21', the processing device 22 ', and the processing device 23'.

For example, the transfer of the sample container c ' between the processing device 21 ' and the processing device 22 ' will be described as an example. The pick-and-place device 40 ' picks up the sample container c at the processing device 21 ' after moving to the corresponding position of the processing device 21 ' in the first direction, and releases the sample container c ' after moving to the corresponding position of the processing device 22 ' in the first direction to place the sample container c ' at the other processing device 22 '.

The first direction is the length direction of the first guide 30'.

Alternatively, the processing device 21 'may be a magnetic separation device 21'. The treatment device 22 'may be an incubation device 22'.

The magnetic separation device 21 'is used for performing magnetic separation treatment on the sample in the sample container c', and the incubation device 22 'is used for performing incubation treatment on the sample in the sample container c'.

Alternatively, the processing device 23 'may be a container recycling device 23', the container recycling device 23 'being adapted to receive a used sample container c'. For example, the pick-and-place device 40 ' transfers the used sample containers c ' in the incubation device 22 ' or the magnetic separation device 21 ' to the container recovery device 23 '.

Referring to fig. 3 in combination, fig. 3 is a schematic structural diagram of a second turntable of the incubation apparatus according to the embodiments of the present application. Alternatively, the magnetic separation device 21 'includes a first base body 211' and a first rotary table 212 'rotatably coupled to the first base body 211', and at least one first receiving hole a 'is provided on the first rotary table 212'. The incubation device 22 'includes a second base 221' and a second turntable 222 'rotatably coupled to the second base 221', and at least one second receiving hole b 'is provided in the second turntable 222', and the container recovery device 23 'has a receiving channel 231'. The second base 221 'is covered on the top and around the second turntable 222' to prevent heat dissipation. As the second turntable 222' cannot be shown in fig. 1 and 2, please understand in conjunction with fig. 3.

For example, taking the transfer of the sample container c between the magnetic separation device 21 ' and the incubation device 22 ' as an illustration, the gripping and placing device 40 ' is enabled to transfer the sample container c ' between the predetermined first accommodation hole a ' and the predetermined second accommodation hole b ' by rotating the first turntable 212 ' and the second turntable 222 ' so that the predetermined first accommodation hole a ' and the predetermined second accommodation hole b ' are located at the corresponding positions of the first guide 30 '.

For another example, when it is desired to transfer the sample container c ' between the magnetic separation device 21 ', the incubation device 22 ', and the receiving channel 231 ', the pick-and-place device 40 ' is enabled to transfer the sample container c ' between the predetermined first receiving hole a ', the predetermined second receiving hole b ', and the receiving channel 231 ' by rotating the first and second turntables 212 ' and 222 ' such that the predetermined first receiving hole a ', the predetermined second receiving hole b ', are located at the corresponding positions of the first guide 30 ', and such that the predetermined first receiving hole a ', the predetermined second receiving hole b ', and the receiving channel 231 ' are located on a straight line.

In this way, the moving path of the grabbing and placing device 40 'among the magnetic separation device 21', the incubation device 22 'and the container recycling device 23' is a straight line, compared with the arc moving track of the traditional swing arm, the space required by movement is greatly saved, and the transferring working efficiency can be improved.

The relative positions of the first guide 30 'and the base 10' are fixed.

The first guide 30 ' may be directly fixed to the base 10 ', or may be indirectly fixed to the base 10 ' through other members. The vertical distance from any point on the first guide 30 'to the lower surface of the base 10' is greater than the vertical distance from any point on the processing apparatus 12 'to the lower surface of the base 10'. For example, when the base 10 ' of the sample analyzer is placed on a horizontal work platform, the first guide 30 ' is located above the processing devices 21 ', 22 ', 23 '.

Optionally, the sample analyzer further comprises a first fixing plate 50 ', and the first guide 30' is relatively fixed to the base 10 'by the first fixing plate 50'.

In a specific embodiment, the sample analyzer further includes a first drive mechanism (not shown) that is disposed on the first stationary plate 50 'and fixedly coupled to the first stationary plate 50'. The first drive mechanism is used to drive the pick and place device 40 'to move in a first direction on the first guide 30'.

The first drive mechanism may include a first motor, a first drive pulley, a first driven pulley, and a first drive belt. The first motor is fixedly disposed on the first fixing plate 50'. The first motor comprises a body and a rotating shaft driven by the body to rotate. The first driving wheel is fixedly sleeved on the rotating shaft of the first motor and rotates along with the rotating shaft of the first motor.

The first driven wheel is rotatably arranged on the first fixed plate 50', and the first driven wheel and the first driving wheel are arranged at intervals in the first direction.

The first driving belt is lapped on the first driving wheel and the first driven wheel, and the first driving belt is used for transmitting the torque on the first driving wheel to the first driven wheel.

The first belt is fixedly connected to the pick-and-place device 40 'at a predetermined position in the length direction, and the first belt is used for driving the pick-and-place device 40' to reciprocate in the first direction.

It should be understood that the specific structure of the first driving mechanism is not limited to the above-described structure, and the driving manner is not limited to the above-described manner as long as the pick-and-place device 40 ' can be driven to reciprocate along the first guide 30 ' with respect to the first fixing plate 50 '.

By arranging the first fixing plate 50 ', the first driving mechanism is facilitated, and by arranging the first guide member 30' on the first fixing plate 50 ', the first fixing plate 50' is fixed on the base 10 ', so that the first guide member 30' and the grabbing and placing device 40 'arranged on the first guide member 30' are relatively fixed with the base 10 ', the first fixing plate 50' and the components arranged on the first guide member are convenient to install and detach, and the maintenance and replacement of the components are facilitated.

Optionally, the sample analyzer further includes a second fixed plate 60 ', the second fixed plate 60 ' being movably disposed on the first guide 30 ' along the first direction, the pick-and-place device 40 ' being connected to the second fixed plate 60 '.

Optionally, the sample analyzer further includes a second guide 70 ', the second guide 70 ' is fixed on the second fixing plate 60 ', and the pick-and-place device 40 ' is movably disposed on the second guide 70 ' along a second direction, and the first direction intersects the second direction.

The second direction is the length direction of the second guide 70'.

In a specific embodiment, the sample analyzer further includes a second drive mechanism (not shown) that is disposed on the second stationary plate 60 'and fixedly coupled to the second stationary plate 60'. The second drive mechanism is used to drive the pick and place device 40 'to move in a second direction on the second guide 70'.

The second drive mechanism may take a similar structure to the first drive mechanism, i.e., the second drive mechanism may include a second motor, a second drive pulley, a second driven pulley, and a second drive belt. The second motor is fixedly arranged on the second fixing plate 60'. The second driving wheel is fixedly sleeved on the rotating shaft of the second motor and rotates along with the rotating shaft of the second motor. The second driven wheel is rotatably arranged on the second fixed plate 60', and the second driven wheel and the second driving wheel are arranged at intervals in a second direction. The second driving belt is lapped on the second driving wheel and the second driven wheel. The predetermined position in the length direction of the second belt is fixedly connected to the pick-and-place device 40'.

In this way, the gripping and placing device 40 can move along the second guide 70 ' in the second direction, and can also move along the second fixing plate 60 ' in the first direction on the first guide 30 ', and the first direction intersects with the second direction, so that the gripping and placing device 40 can move in two different directions, so as to achieve gripping, moving and placing of the sample containers c ' in the at least two processing devices 21 ', 22 ' and 23 ' in different positions and different planes, and further enable overlapping arrangement between the processing devices in the space along the second direction in the sample analyzer, which is more beneficial to the overall miniaturization design of the instrument.

Optionally, the first direction is perpendicular to the second direction. For example, the first direction is a direction parallel to the upper surface of the first turntable 212 ', and the second direction is a direction perpendicular to the upper surface of the first turntable 212'. Specifically, when the base 10' of the sample analyzer is placed on a horizontal work platform, the first direction may be a horizontal direction and the second direction may be a vertical direction.

Optionally, the sample analyzer further comprises a container adding device 80 ', the container adding device 80' being for adding a sample container c 'to the incubation device 22', the height of the container adding device 80 'relative to the base 10' being greater than the height of the incubation device 22 'relative to the base 10'. The fixed position of the first fixing plate 50 'on the container adding device 80' is higher than the position of the incubation device 22 'and higher than the position of the magnetic separation device 21'.

Alternatively, the container adding device 80 'includes a device main body 81', a bin body 82 ', and a container passage 83', the bin body 82 'is fixed to the base 10' by the device main body 81 ', the container passage 83' is connected to the bin body 82 'at a discharge port e' of the bin body 82 ', the bin body 82' has a bin inlet d 'at a side away from the device main body 182', a sample container c 'is externally put into the bin body 82' from the bin inlet d ', and the sample container c' in the bin body 82 'is conveyed into a second accommodating hole b' of the incubation device 22 'through the container passage 83'. The height of the cartridge 82 ' relative to the base 10 ' is greater than the height of the incubation device 22 ' relative to the base 10 ' such that the sample containers c ' are fed into the second receiving holes b ' of the incubation device 22 ' after exiting from the outlet e ' through the container channel 83 '.

The sample container c 'in the bin 82' is conveyed to the incubation device through a container channel, the container channel 83 'comprises a chute h1 and a dispatching disc h2, the chute h1 is obliquely arranged relative to the bottom surface of the base 10', a plurality of placing holes f are formed in the dispatching disc h2, and the axial direction of the placing holes f is perpendicular to the bottom wall of the chute h 1. In this way, the sample container c 'can be caused to fall onto the incubation device 22' under its own weight.

The container adding device 80 ' further comprises a spring plate (not shown), wherein one end of the spring plate is fixed with the container channel 83 ', and the other end of the spring plate extends into the bin outlet e ' for removing the sample container c ' with an unsatisfactory posture, so that the bin outlet e ' is prevented from being blocked. The first fixing plate 50 'is fixed at a position higher than the position of the incubation means 22' and higher than the position of the magnetic separation means 21 'on the outer surface of the cartridge body 82'.

By fixing the first fixing plate 50 ' to the outer surface of the cartridge body 82 ', on the one hand, the positional relationship that the cartridge body 82 ' is located above the incubation device 22 ' is utilized, and on the other hand, a portion for fixing the first fixing plate 50 ' is not required to be provided on the base 10 ', so that the structure of the base 10 ' is simplified, and the overall volume of the sample analyzer is further reduced.

Optionally, the position of the incubation means 22 'where the sample container c' is placed is higher relative to the base 10 'than the position of the magnetic separation means 21' where the sample container c 'is placed relative to the base 10'.

By the above mode, the incubation device 22 'is arranged above the magnetic separation device 21', so that the incubation device and the magnetic separation device are arranged in the sample analyzer in a space overlapping mode along the second direction, and compared with the arrangement mode that the incubation device and the magnetic separation device are arranged at the same height, the transverse volume of the sample analyzer can be further reduced, and the longitudinal space of the sample analyzer is fully utilized.

Referring to fig. 4 and 5, fig. 4 is a schematic structural diagram of a magnetic separation device according to an embodiment of the present application. Fig. 5 is a schematic structural view of a first implementation of the magnetic element layout according to the embodiment of the present application.

In this embodiment, the magnetic separation device includes a base 10, a turntable 11, and a magnetic member 12.

The base 10 is provided with a receiving groove.

The turntable 11 is rotatably arranged in the receiving groove, and the turntable 11 is provided with at least one receiving hole a for receiving a sample container b containing a sample and/or a magnetic compound.

Alternatively, the turntable 11 has a cylindrical shape, and each receiving hole a is equidistant from the axis of rotation of the turntable 11. The receiving hole a is provided adjacent to an edge position of the turntable 11, i.e., in an edge region of the turntable 11. The edge area refers to a position closer to the edge of the turntable 11 with respect to the center of the turntable 11 and the edge of the turntable 11. In the above manner, on the one hand, more accommodation holes a can be laid out on the same-sized turntable 11 to accommodate the sample containers b; on the other hand, the distance between the accommodating hole a and the magnetic piece 12 on the base 10 can be made closer, and the adsorption effect of the magnetic piece 12 on the magnetic compound can be improved. The plurality of receiving holes a may be annularly distributed and equally spaced apart.

A magnetic member 12 is provided on the base 10 for adsorbing the magnetic composite in the sample container b to the inner wall of the sample container b.

The magnetic complex may include a magnetic sphere, an antigen or antibody on the surface of the magnetic sphere, and an analyte in blood bound to the antigen or antibody. The surface of the magnetic ball is modified to have a coating structure and also has a functional group, the functional group is combined with an antigen or an antibody and the like, the antigen or the antibody is combined with an object to be detected in blood to gradually form a large immune complex, and the immune complex (namely, a target detection object) is finally obtained through magnetic separation, separation and cleaning and is sent into a flow chamber of a detection device along with sheath fluid for detection. During magnetic separation and cleaning, immune complex is adsorbed on the inner wall of a sample container, supernatant is sucked away, the immune complex adsorbed on the inner wall is released at a detection station, and the immune complex is sucked into a flow chamber of the detection device for optical detection.

It is understood that the magnetic complex may be either the reaction substrate prior to reaction: for example, a magnetic-sphere mixture coated with a capture antibody may be used as the magnetic-sphere target detection substance formed after the reaction. In addition, it will be appreciated that the sample container may include other substances that participate in the reaction, such as: reagents, ligands, dilutions, and the like.

Optionally, at least one detection station J is provided on the base 10, the detection station J being non-magnetic or controllable to be non-magnetic, so that the detection device is facilitated to aspirate the magnetic compound in the sample container b as the sample container b rotates with the turntable 11 to the detection station J.

Alternatively, the detection station J can also be controlled to be magnetic, so that magnetic separation and cleaning can also be performed at the detection station J; that is, in this case, the detection station J can perform both suction detection of the magnetic composite and magnetic separation and washing. For example, the magnetic member 12 located at the detection station J is configured as a controllable magnetic member, and further, the magnetic separation or suction detection at the detection station J is achieved by controlling the presence or absence of magnetism of the controllable magnetic member, which may be an electromagnet. See in particular the description of specific embodiments below.

Referring to fig. 6 in conjunction with fig. 4 and 5, fig. 6 is a schematic diagram illustrating a positional relationship between a detection device and a magnetic separation device according to an embodiment of the present application. The sample suction needle 41 of the detection device 40 is movable or rotatable to the detection station J and is extendable into the sample container b to suck the target detection object in the sample container b located at the detection station J. Optionally, the magnetic separation device further comprises a mixing mechanism disposed at the detection station J, and the mixing mechanism is used for mixing the magnetic compound and the liquid in the sample container b rotating along with the turntable 11 to the detection station J. Alternatively, the mixing mechanism may be the suction needle 41 of the detection device 40. The detection device 40 controls the discharge or suction of the sample from the sample suction needle 41 to mix the sample, that is, to suck and mix the sample. Of course, in other embodiments, a mixing mechanism may be separately disposed adjacent to the detection station J, and the embodiments of the present application are not limited to the manner in which the sample suction needle 41 of the detection device 40 is used for mixing. For example, the mixing mechanism is a stirring rod 42 provided in the detection device 40, and the sample is stirred and mixed by the stirring rod 42.

Optionally, at least one pipetting station X is provided on the base 10, and the magnetism generated by the magnetic member 12 increases gradually from the detection station J to the pipetting station X.

The magnetic separation device may further comprise a first support 13, a light emitter 14, a light receiver 15, a shutter 16, a washing container 17, a pipetting assembly 18, a pipetting assembly 19, a support bar 20, a stationary connection holder 31, and a sample container detection assembly 32. Where the pipetting assembly 18 is arranged at the pipetting station X. The light emitter 14 and the light receiver 15 are fixed on the base 10 through the first bracket 13, and the light emitter 14 and the light receiver 15 are oppositely arranged and are arranged at intervals. The shielding member 16 is fixed to the turntable 11, and when the shielding member 16 rotates with the turntable 11 to a position corresponding to the light emitter 14 and the light receiver 15, the shielding member 16 is partially located between the light emitter 14 and the light receiver 15 to shield the light emitted from the light emitter 14 toward the light receiver 15.

For example, when the shutter 16 rotates with the turntable 11 to the position corresponding to the light emitter 14 and the light receiver 15, the light emitted from the light emitter 14 toward the light receiver 15 is blocked by the shutter 16, and the light receiver 15 cannot receive the light emitted from the light emitter 14; when the shielding member 16 is not at the position corresponding to the light emitter 14 and the light receiver 15, the light receiver 15 can receive the light emitted from the light emitter 14, so that the magnetic separation device can determine the initial position of the rotation of the turntable 11 by whether the light receiver 15 can receive the light emitted from the light emitter 14.

In this embodiment, the cleaning container 17 is fixed to the turntable 11 at a position corresponding to the shutter 16 and is inserted into the escape hole in the shutter 16. The cleaning container 17 is arranged at the corresponding position of the shielding piece 16, so that the magnetic separation device is compact in structure and convenient to miniaturize, and the cleaning container 17 is allowed to be exposed through the avoiding holes formed in the shielding piece 16, so that the cleaning of the liquid suction assembly 18 or the liquid adding assembly 19 is not influenced. In another embodiment, the purge vessel 17 may be secured to the shield 16. By fixing the cleaning container 17 to the shutter 16, the structure of fixing the cleaning container 17 is not additionally provided, so that the structure of the magnetic separation device is relatively simple.

The pipetting assembly 18 is fixed to the base 10 and is adapted to aspirate liquid from the sample container b rotated with the turntable 11 to the position where the pipetting assembly 18 is located. Specifically, the pipetting assembly 18 includes a second rack 181, a third rack 182, a pipetting needle 183, and a washing needle 184. The second bracket 181 is fixed to the base 10, and the third bracket 182 is movably provided on the second bracket 182 in a direction parallel to the rotation axis of the turntable 11, close to or away from the turntable 11. The pipetting needle 183 and the washing needle 184 are fixed to the third holder 182, and the washing needle 184 is shorter than the pipetting needle 183 so that the outer wall of the pipetting needle 183 can be washed when the washing needle 184 discharges liquid.

Specifically, the length of the liquid sucking needle 183 is longer than the length of the cleaning needle 184, the relative positions of the liquid sucking needle 183 and the cleaning needle 184 are fixed and the outer walls thereof are arranged to be abutted against each other, and the liquid outlet of the cleaning needle 184 is positioned at a height with respect to the base 10 that is greater than the liquid sucking opening of the liquid sucking needle 183 with respect to the base 10.

When the sample container b rotates with the turntable 11 to below the pipetting needle 183 and the washing needle 184, the magnetic separation device controls the pipetting needle 183 and the washing needle 184 to extend into the sample container b for pipetting.

The cleaning container 17 is used for cleaning the liquid absorbing assembly 18 when rotating along with the turntable 11 to the position where the liquid absorbing assembly 18 is located. Specifically, when the cleaning container 17 rotates with the turntable 11 to the position below the liquid suction needle 183 and the cleaning needle 184, the magnetic separation device controls the liquid suction needle 183 and the cleaning needle 184 to move downward and extend into the cleaning container 17, the cleaning needle 184 and the liquid suction needle 183 simultaneously discharge liquid, the liquid discharged by the cleaning needle 184 cleans the outer wall of the liquid suction needle 183, and the liquid discharged by the liquid suction needle 183 cleans the inner wall of the liquid suction needle 183, so that the cleaning efficiency can be greatly improved in the above manner.

The filling assembly 19 is fixed to the base 10 and is adapted to fill the sample container b rotated with the turntable 11 to the position of the filling assembly 19. The injected liquid may be a reagent. The liquid charging assembly 19 is located at a liquid charging station T on the base 10. Optionally, the magnetism of the liquid adding station T is weaker than that of the liquid absorbing station X, and the magnetism of the liquid adding station T is stronger than that of the detecting station J.

Optionally, the charging assembly 19 includes a fourth bracket 191, a fifth bracket 192, and a charging needle 193. The fourth bracket 191 is fixed to the base 10, and the fifth bracket 192 is movably provided on the fourth bracket 191 in a direction parallel to the rotation axis of the turntable 11, close to or away from the turntable 11. The filling needle 193 is fixed to the fifth bracket 192. The fifth bracket 192 may be fixedly arranged on the fourth bracket 191, so that the liquid adding needle 19 cannot move up and down, and the cost for designing the driving mechanism for moving up and down is saved.

It should be understood that the filling needle 193 may be fixedly disposed with respect to the base 10 so as not to be movable up and down, and the cleaning vessel 17 may be used only for cleaning the pipette needle 183.

In another embodiment, the magnetic separation device controls the feeding needle 193 to move downward to extend into the sample container b as the sample container b rotates with the turntable 11 to below the feeding needle 193, and then the feeding needle 193 discharges the liquid to feed the liquid into the sample container b.

The cleaning container 17 is further used for cleaning the liquid adding assembly 19 when the liquid adding assembly 19 is located along with the rotation of the turntable 11. Specifically, when the cleaning vessel 17 rotates with the turntable 11 to below the liquid feeding needle 193, the magnetic separator controls the liquid feeding needle 193 to move downward, and the liquid feeding needle 193 is inserted into the cleaning vessel 17 to be cleaned.

The fixed connection seat 31 is connected with the base 10 through the support rod 20. Alternatively, the number of support bars 20 is four. In other embodiments, the number of support rods 20 may be three. The fixed connection seat 31 is used for fixing with other structures.

The sample container detection assembly 32 includes a sixth bracket 321 and a detection sensor 322 disposed on the sixth bracket 321. The detection sensor 322 is configured to detect whether or not the sample container b is placed in a certain accommodation hole b when the accommodation hole b is rotated to a position corresponding to the detection sensor 322. Alternatively, the detection sensor may be an optocoupler, and in particular may be a reflective optocoupler.

Embodiments of the first inspection station and the first magnetic member arrangement are described below in conjunction with fig. 5, 7, and 8.

Fig. 7 is a schematic top view of a first embodiment of a magnetic element layout of the present application. Fig. 8 is a schematic diagram showing the positional relationship among the magnetic member, the turntable, and the accommodating hole in the first embodiment of the magnetic member layout of the present application.

In the first embodiment, the magnetic member 12 is provided on the base 10. The number of the magnetic pieces 12 is plural, and the plurality of the magnetic pieces 12 corresponds to the number of the accommodating holes one by one. At least one magnetic element 12 (a) of the plurality of magnetic elements 12 is a controllable magnetic element, the remaining magnetic elements 12 are permanent magnets, and the controllable magnetic element is disposed at the detection station J.

Alternatively, one magnetic element 12 (a) of the plurality of magnetic elements 12 is a controllable magnetic element, and the remaining magnetic elements 12 are permanent magnets; correspondingly, the number of the detection stations J is one, and the controllable magnetic pieces are positioned in the detection stations J.

It should be appreciated that a plurality of inspection stations J may be provided, and that when the number of inspection stations J is plural, the magnetic members 12 (a) of each inspection station J are each designed as a controllable magnetic member. When the number of the detecting stations J is designed to be plural, the detecting efficiency of the target detecting object in the sample container b on the turntable 11 can be improved.

When a certain sample container b rotates to a position where the controllable magnetic piece is located (namely a detection station J), the magnetic separation device controls the controllable magnetic piece to generate a magnetic field so that the magnetic compound is adsorbed on the inner wall of the sample container b for magnetic separation, and/or controls the controllable magnetic piece not to generate magnetism so that the detection device J can absorb the magnetic compound in the sample container.

For example, the controllable magnetic member is an electromagnet, and the magnetic separation device controls the presence or absence of magnetism of the electromagnet by energizing or de-energizing the electromagnet. Specifically, for example, when energized, the electromagnet produces magnetism, and when not energized, the electromagnet does not produce magnetism. It should be understood that the controllable magnetic member is not limited to the case of using an electromagnet, and other controllable magnetic members that can be selectively controlled to be magnetic or non-magnetic are also within the scope of the present application.

In this embodiment, the first specific implementation way of gradually increasing the magnetism generated by the magnetic member 12 from the detection station J to the liquid absorbing station X is: the area of the surface of each magnetic piece 12, which is close to one side of the turntable 11, gradually increases from the detection station J to the liquid suction station X; the second specific implementation mode is as follows: the thickness of each magnetic member 12 increases gradually from the inspection station J to the pipetting station X. It should be appreciated that in other embodiments, the progressive increase in magnetic properties from inspection station J to pipetting station X may also be accomplished in combination with the first and second implementations, e.g., progressive increases in the area and thickness of each magnetic member 12 from inspection station J to pipetting station X.

Optionally, magnetic member 12 is disposed adjacent to an edge of turntable 11, and base 10 is provided with a first notch q1 at a position corresponding to magnetic member 12, and magnetic member 12 is exposed toward turntable 11 through first notch q 1. In the above manner, the magnetic member 12 is exposed toward the side of the rotation axis of the turntable 11, and the adsorption effect of the magnetic member 12 on the magnetic compound in the sample container b is increased.

Optionally, the turntable 11 is provided with a second notch q2 at a position corresponding to the accommodation hole a, and the sample container b placed in the accommodation hole a is exposed toward the base 10 through the second notch q 2.

In this way, the sample container b placed in the accommodating hole a is exposed towards the base 10 through the second notch q2, so as to increase the adsorption effect of the magnetic component 12 on the magnetic compound in the sample container b.

As shown in fig. 8, the surface of the magnetic member 12 near the accommodation hole a is a plane, the accommodation hole a is a circular hole, and the surface of the magnetic member 12 near the accommodation hole a is perpendicular to a reference plane ABCD defined by the rotation axis AB of the turntable 11 and the axis CD of the accommodation hole a.

Alternatively, the length of the magnetic member 12 is equal to the depth of the accommodation hole a, so that the magnetic composite can be adsorbed at different positions in the height direction on the inner wall of the portion of the sample container b in the accommodation hole a, and the adsorption efficiency is improved. The upper end of the magnetic member 12 may be flush with the upper end of the receiving hole a, and the lower end of the magnetic member 12 may be flush with the bottom of the receiving hole a.

Alternatively, magnetic member 12 may be rectangular in shape, i.e., each surface of magnetic member 12 is planar. In other embodiments, only the surface of the magnetic member 12 near the accommodation hole a may be provided as a plane.

Because the magnetic piece 12 is in a cuboid shape, the magnetic piece 12 is in a plate shape, the processing difficulty is low, the cost can be effectively reduced, and the required effect can be achieved.

Referring to fig. 9 in combination, fig. 9 is a schematic diagram of the magnetic attraction principle of the first layout mode of the magnetic elements in the present application. Alternatively, one of the two ends of the magnetic member 12 along the direction of the rotation axis of the turntable 11 is an S pole, and the other is an N pole. In this way, the magnetic composite Q in the sample container b can be adsorbed on two lines of two positions on the inner wall of the sample container b corresponding to both ends of the magnetic member 12 in the direction of the rotation axis of the turntable 11. For example, as shown, magnetic composite Q is adsorbed on the inner wall of sample container b and corresponds to two lines at the upper and lower ends of magnetic member 12.

In other embodiments, the magnetic member 12 may have magnetism only at both end portions in the direction of the rotation axis of the turntable 11, and have no magnetism at the intermediate section between the both end portions, and one of the side close to the accommodation hole a corresponding to the magnetic member 12 and the side away from the accommodation hole corresponding to the magnetic member 12 is an S-pole, and the other is an N-pole, among the both end portions, so that the magnetic composite Q is intensively adsorbed on the inner wall of the sample container b at a position corresponding to the both end portions.

A second embodiment of the inspection station is described below in conjunction with fig. 10. Fig. 10 is a schematic structural view of a push-pull mechanism according to an embodiment of the present application. The second embodiment of the detection station is also realized in the arrangement of the first magnetic element.

In a second embodiment, magnetic element 12 is disposed on base 10. The number of the magnetic pieces 12 is plural, and the plurality of magnetic pieces 12 corresponds to the number of the accommodation holes a one by one. The plurality of magnetic members 12 are permanent magnets. The magnetic element 12 (a) located at the detection station J is detachably disposed in a corresponding mounting hole on the base, and the other magnetic elements 12 not located at the detection station J may be fixed in the corresponding mounting holes of the base 10.

It should be understood that the number of the detecting stations J may be plural, and when the number of the detecting stations J is plural, the magnetic members 12 at the detecting stations J are all detachably disposed in the corresponding mounting holes on the base 10.

The magnetic separation device further comprises a push-pull mechanism 21, wherein the push-pull mechanism 21 is used for pulling the magnetic piece 12 (a) positioned at the detection station J away from the mounting hole when the sample container b rotates to the detection station J along with the turntable 11 so as to facilitate the detection device 40 to absorb the magnetic compound in the sample container b; alternatively, magnetic member 12 (a) is pushed into the mounting hole to attract the magnetic composite before sample container b rotates with turntable 11 to pipetting station X.

Alternatively, the push-pull mechanism 21 includes a fixed base plate 211 fixed relative to the base 10, a slider 212 slidably disposed on the fixed base plate 211, a push plate 213 fixed on the slider 212, and a power mechanism 214 driving the slider 212 to slide relative to the fixed base plate 211, the push plate 213 being connected to the magnetic member 12 (a), the power mechanism 214 driving the push plate 213 to move when the slider 212 is driven to slide relative to the fixed base plate 211 to push the magnetic member 12 (a) into the mounting hole on the base 10 or to pull the magnetic member 12 (a) out of the mounting hole on the base 10.

Alternatively, the power mechanism 214 includes a motor 214a fixed on the fixed base plate 211, a driving wheel 214b disposed on a rotating shaft of the motor 214a, a driven wheel 214c rotatably disposed on the fixed base plate 211, and a driving belt 214d sleeved on the driving wheel 214b and the driven wheel 214c, wherein the driving belt 214d is fixed with the slider 212 at one position along the length direction. The belt 214d may be a timing belt.

Alternatively, the pushing plate 213 includes a first connecting plate 213a and a second connecting plate 213b connected to the first connecting plate 213a in a bending manner, the first connecting plate 213a is fixed to the slider 212, and the second connecting plate 213b is connected to the magnetic member 12 (a).

Optionally, the push-pull mechanism 21 further includes a sliding rail 215, the sliding rail 215 is disposed on the fixed substrate 211, and the sliding block 212 is slidably disposed on the fixed substrate 211 through the sliding rail 215.

It should be appreciated that in other embodiments, the push-pull mechanism may take other configurations, so long as it is capable of extracting magnetic element 12 (a) from the mounting hole and pushing magnetic element 12 (a) into the mounting hole.

A third embodiment of the inspection station is described below in conjunction with fig. 12. Fig. 12 is a schematic view of an implementation structure of a third detection station of the present application. In a third implementation of inspection station J, magnetic element 12 is arranged in a manner similar to the first arrangement. The difference is that the detecting station J is a vacancy, and no magnetic member 12 is arranged, i.e. the detecting station J has no magnetism.

In the third inspection station embodiment, the number of magnetic elements 12 is plural, and the plurality of magnetic elements 12 may be permanent magnets. The number of magnetic pieces 12 is smaller than the number of receiving holes a, and a first pitch between at least one set of two adjacent magnetic pieces 12 (b) and 12 (c) is larger than a second pitch between any other adjacent two magnetic pieces 12, and a difference between the first pitch and the second pitch is larger than or equal to a width of one magnetic piece 12, and a detection station J is located between at least one set of two adjacent magnetic pieces 12 (b) and 12 (c). In other words, no magnetic element is provided at the inspection station J, i.e., the two sides of the inspection station J correspond to the two magnetic elements 12 (b) and 12 (c) in close proximity with each other by at least the width of one magnetic element 12.

An embodiment of the fourth inspection station and layout of the second magnetic element is described below in conjunction with fig. 13 and 14. Fig. 14 is a schematic structural view of a fourth inspection station according to an embodiment of the present application. Fig. 13 is a schematic structural view of a magnetic element in a second magnetic element layout manner according to the embodiment of the present application.

The fourth embodiment of the detecting station is based on the layout mode of the second magnetic elements, in the layout mode of the second magnetic elements, the number of the magnetic elements 22 is one, and the magnetic elements 22 are annular and encircle the periphery of the turntable 11.

As described above, the magnetic member 22 is disposed on the base 10. As shown in fig. 9, in the present embodiment, the magnetic member 22 is fixed to a side wall of the accommodation groove on the base 10. In other embodiments, the base may be provided with an annular groove, and the magnetic member is embedded in the annular groove. The base is provided with the breach that corresponds with the accommodation hole, and the magnetic part exposes towards the carousel through the breach.

The implementation mode of the fourth detection station is as follows: the annular magnetic member 22 has a notch 221 at the position of the inspection station J.

Alternatively, one of the two ends of the magnetic member 22 along the direction of the rotation axis of the turntable 11 is an S pole, and the other is an N pole. In this way, the magnetic composite in the sample container b can be adsorbed on a line closest to the inner wall of the magnetic member 22 (a bus bar closest to the magnetic member 22 when the side wall of the sample container b is a cylindrical surface), and further, the magnetic composite is concentrated to the greatest degree at the upper and lower ends of the sample container b.

Alternatively, the size of the X magnetic member 22 in the direction along the rotation axis of the turntable 11 from the detection station J to the pipetting station is gradually increased, in other words, the magnetic attraction area from the detection station J to the pipetting station X magnetic member 22 is gradually increased, so that the magnetism generated from the detection station J to the pipetting station X magnetic member 22 is gradually increased. In other embodiments, a gradual increase in thickness of magnetic member 12 from detection station J to pipetting station X may be provided, whereby a gradual increase in magnetic properties may also be achieved. It should be appreciated that the gradual increase in magnetic properties may be achieved by combining a gradual increase in thickness and magnetic attraction area, or by combining materials of the magnetic member, for example, by differing magnetic properties of the materials used for the magnetic member.

A fifth embodiment of the inspection station is described below in conjunction with fig. 14. The fifth implementation of the detection station may be based on the layout of the first magnetic element or the layout of the second magnetic element.

Referring to fig. 14, fig. 14 is a schematic structural diagram of a fifth inspection station according to an embodiment of the present application.

In a fifth inspection station embodiment, magnetic element 12 is disposed on base 10. The number of the magnetic pieces 12 is plural, and the number of the magnetic pieces 12 corresponds to the number of the accommodation holes a one by one. The plurality of magnetic members 12 may be permanent magnets, and the turntable 11 is further provided with a detection position accommodating hole a1, and the arrangement of the magnetic members 12 is similar to that of the first arrangement. In the present embodiment, the turntable 11 is provided with a detection position accommodation hole a1. The distance from the detection position accommodating hole a1 to the center position of the turntable 11 is smaller than the distance from the accommodating hole a to the center position of the turntable 11, so that the distance from the detection position accommodating hole a1 to the magnetic member 12 is longer than the distance from the accommodating hole a to the magnetic member 12, the magnetic force of the magnetic member 12 received by the detection position accommodating hole a1 is smaller, and thus when the sample container b is transferred from the accommodating hole a to the detection position accommodating hole a1, the magnetic composite adsorbed on the side wall of the sample container b slides to the bottom of the sample container b, so that the detection device 40 can absorb the magnetic composite. Alternatively, the detection position accommodation hole a1 is provided at the center position of the turntable 11.

It should be appreciated that the fifth inspection station may also be implemented in the layout of the second magnetic element. The same applies to the case where the magnetic member 22 is provided in a ring shape around the turntable 11, and the detection position receiving hole a1 is provided in the turntable 11.

Alternatively, in this embodiment, the magnetic separation device may further include a gripping and transferring device for gripping and transferring the sample container b between the accommodation hole a and the detection site accommodation hole a 1.

Referring to fig. 15, fig. 15 is a schematic structural diagram of a sixth detection station according to an embodiment of the present application.

The sixth embodiment of the inspection station is based on a third arrangement of magnetic elements in which the magnetic elements 52 are arranged on the turntable 11. The number of the magnetic pieces 52 is plural, and the plurality of magnetic pieces 52 corresponds to the number of the accommodation holes a one by one. The magnetic member 52 is annular and disposed within the receiving hole a and around the sample container b.

In the above manner, the magnetic member 52 is disposed around the sample container b, so that the magnetic compound can be adsorbed everywhere on the inner sidewall of the sample container b, and the adsorption effect of the magnetic compound is improved. Further, the magnetic member 12 with a circular cross section surrounds the sample container b, so that the magnetic composites adsorbed on the inner side wall of the sample container b are uniformly distributed, each magnetic composite can be subjected to uniform magnetic force, and the loss of the magnetic composite caused in the liquid suction process is reduced.

Referring to fig. 16 in conjunction with fig. 15, fig. 16 is a schematic diagram illustrating a magnetic attraction principle in a third magnetic element layout mode according to the present application.

Alternatively, one of the two ends of the magnetic member 52 along the direction of the rotation axis of the turntable 11 is S-pole, and the other is N-pole. The magnetic composite Q may be concentrated on two lines (two broken lines as shown in the figure) on the inner wall of the sample container b corresponding to the positions of both ends of the magnetic member in the direction of the rotation axis of the turntable 11 (for example, both upper and lower ends of the magnetic member as shown in the figure).

In this embodiment, the extraction mechanism is arranged in a similar manner to the above embodiment, specifically referring to the structure of the extraction mechanism described above. See in particular the structure of the extraction mechanism described above.

There are two detection station implementations based on the third magnetic part layout. The first implementation mode of the detection station of the third magnetic part layout mode is as follows: the plurality of magnetic pieces 52 are controllable magnetic pieces 52, and when the sample container b rotates to the detection station J along with the turntable 11, the magnetic separation device controls the magnetic pieces 52 (a) corresponding to the sample container b not to generate magnetism so as to facilitate the detection device 40 to absorb the magnetic compound; and/or the magnetic separation device controls the magnetic member 52 (a) to generate magnetism so that the magnetic composite is adsorbed to the inner wall of the sample container b to perform magnetic separation.

The second implementation mode of the detection station of the third magnetic part layout mode is as follows: the magnetic pieces are arranged on the turntable 11 in a removable way, and the magnetic separation device further comprises a push-pull mechanism, wherein the push-pull mechanism is used for removing the magnetic piece corresponding to the sample container b from the turntable 11 when the sample container b rotates along with the turntable 11 to the detection station J so as to facilitate the detection device 40 to absorb the magnetic compound in the sample container b; alternatively, the corresponding magnetic member 52 may be pushed into the turntable 11 to attract the magnetic composite before the sample container c rotates with the turntable to the pipetting station X. The specific structure of the push-pull mechanism can be referred to the above description, and will not be repeated here.

Referring to fig. 17, fig. 17 is a schematic structural diagram of a seventh detection station according to an embodiment of the present application.

The seventh embodiment of the inspection station is based on a fourth arrangement of magnetic elements in which the magnetic elements 62 are arranged on the turntable 11. The magnetic member 62 is disposed at a side of the corresponding accommodating hole a, and is fixedly embedded on the turntable 11.

Each receiving hole a is for receiving a corresponding one of the sample containers b containing the sample and/or the magnetic compound such that the magnetic compound in the sample container b is attached to the inner wall of the sample container b by the adsorption of the magnetic member 62.

Since the magnetic composite in each sample container b is attracted to the magnetic member 62 disposed in the sample container b in the same direction, and the relative positions of the magnetic members 62 with respect to the corresponding sample container b are the same, the attraction of the magnetic composite in the sample container b by the magnetic members 62 adjacent to the two magnetic members is also in the similar direction of the attraction of the magnetic members 62 disposed in the sample container b, and therefore the attraction effect of the magnetic composite can be improved.

Since the magnetic member 62 is fixed to the turntable 11, the magnetic member 62 rotates with the turntable 11, and when the turntable 11 rotates, the relative positions of the magnetic member 62, the accommodation hole a and the sample container b are unchanged, and the direction of the attraction force of the magnetic member 62 to the magnetic composite is unchanged. Adsorption can be performed while the turntable 11 rotates, and work efficiency and adsorption efficiency of magnetic separation can be improved.

The surface of the magnetic member 62 near the accommodation hole a is a plane, the accommodation hole a is a circular hole, and the surface of the magnetic member 62 near the accommodation hole a is perpendicular to a reference plane defined by the rotation axis of the turntable 11 and the axis of the accommodation hole a.

Alternatively, the length of the magnetic member 62 is equal to the depth of the accommodation hole a, so that the magnetic composite can be adsorbed at different positions in the height direction on the inner wall of the portion of the sample container b in the accommodation hole a, improving the adsorption efficiency. For example, the upper end of the magnetic member 62 may be flush with the upper end of the receiving hole a, and the lower end of the magnetic member 62 may be flush with the bottom of the receiving hole a.

Alternatively, the magnetic member 62 is rectangular in shape, i.e., each surface of the magnetic member 62 is planar. In other embodiments, only the surface of the magnetic member 62 near the accommodation hole a may be provided as a plane.

Because the magnetic piece 62 is in a cuboid shape, the magnetic piece 62 is in a plate shape, the processing difficulty is low, the cost can be effectively reduced, and the required effect can be achieved.

Alternatively, the surface of the magnetic member 62 near the receiving hole a is spaced from the receiving hole a without direct contact, and the magnetic member 62 is embedded in the turntable 11. Since the magnetic member 62 is placed at a position not in contact with the sample container b, erosion of the magnetic member 62 due to liquid possibly scattered during the liquid suction process can be prevented, and the magnetic loss of the magnetic member 62 can be reduced.

In the present embodiment, the magnetic member 62 is provided at a side of the corresponding accommodation hole a near the rotation axis of the turntable 11. In this way, the receiving hole a can be designed closer to the edge of the turntable 11, and more receiving holes a can be laid out with a certain size of the turntable 11.

In other embodiments, the magnetic member 62 may be disposed on a side of the corresponding receiving hole a away from the rotation axis of the turntable 11, which is not limited in the embodiment of the present application.

There are two detection station implementations based on the fourth magnetic part layout. The first implementation mode of the detection station of the fourth magnetic part layout mode is as follows: the plurality of magnetic pieces 62 are controllable magnetic pieces 62, and when the sample container b rotates to the detection station J along with the turntable 11, the magnetic separation device controls the magnetic pieces 62 (a) corresponding to the sample container b not to generate magnetism so as to facilitate the detection device 40 to absorb the magnetic compound; and/or the magnetic separation device controls the magnetic member 62 (a) to generate magnetism so that the magnetic composite is adsorbed to the inner wall of the sample container b to perform magnetic separation.

The second implementation mode of the detection station of the fourth magnetic part layout mode is as follows: the magnetic pieces are all arranged on the turntable 11 in a removable way, and the magnetic separation device further comprises a push-pull mechanism, wherein the push-pull mechanism is used for removing the magnetic piece 62 corresponding to the sample container b from the turntable 11 when the sample container b rotates along with the turntable 11 to the detection station J so as to facilitate the detection device 40 to absorb the magnetic compound in the sample container b; alternatively, the corresponding magnetic member 62 may be pushed into the turntable 11 to attract the magnetic composite before the sample container c rotates with the turntable to the pipetting station X. The specific structure of the push-pull mechanism can be referred to the above description, and will not be repeated here.

It should be understood that the first substrate 211' in the above embodiment may refer to the susceptor 10. The first turntable 212' may refer to the turntable 11. The sample container c' may refer to the sample container b. The first receiving hole a' may refer to the receiving hole a, except that similar designations and different reference numerals are used in the different embodiments.

The sample analyzer of the embodiment of the present application includes the magnetic separation device described in the above embodiment.

The flow type fluorescence immunoassay analyzer of the embodiment of the application comprises a detection device and the magnetic separation device of any embodiment, wherein the detection device comprises a flow chamber, and the detection device is used for sucking a target detection object in a sample container of the magnetic separation device into the flow chamber for optical detection.

Referring to fig. 18, fig. 18 is a flowchart illustrating a control method of the sample analyzer according to the first embodiment of the present application.

In this embodiment, the control method of the sample analyzer may include the steps of:

step S101: the control catch device is moved on the first guide in a first direction to a position corresponding to one of the at least two handling devices.

Step S102: the control catch and release device catches the sample container at the processing device.

Step S103: the control catch device is moved on the first guide in a first direction to a position corresponding to another of the at least two handling devices.

Step S104: the control catch and release device releases the sample container to place the sample container at another processing device.

Optionally, the at least two processing means comprise magnetic separation means for magnetically separating the sample in the sample container and incubation means for incubating the sample in the sample container.

For example, in one embodiment, the pick-and-place device transfers the sample container from the incubation device to the magnetic separation device.

The step S101 may specifically be: after the incubation device completes incubation of the sample in the sample container, the gripping and placing device is controlled to move on the first guide member to a corresponding position of the incubation device along the first direction.

The step S102 may specifically be: the control catch device catches the sample container at the incubation device.

The step S103 may specifically be: the control catch device moves on the first guide piece along the first direction to the corresponding position of the magnetic separation device.

The step S104 may specifically be: the control catch and release device releases the sample container to place the sample container at the magnetic separation device.

Optionally, the at least two processing means further comprise container recycling means for receiving used sample containers.

For example, in another embodiment, the pick-and-place device transfers the discarded sample containers from the magnetic separation device to the container recovery device.

The step S101 may specifically be: after the detection device finishes sucking the sample in the sample container, the grabbing and placing device is controlled to move to a position corresponding to the magnetic separation device on the first guide piece along the first direction.

The step S102 may specifically be: the control catch device catches the sample container at the magnetic separation device.

The step S103 may specifically be: the control catch device moves on the first guide member along the first direction to the corresponding position of the container recycling device.

The step S104 may specifically be: the control catch and release device releases the sample container to place the sample container at the container retrieval device.

It will be appreciated that transfer of sample containers between any two processing devices may be performed, the above merely exemplifies two situations, and the other situations are not listed here.

The embodiment of the application comprises the following steps of: a base; the at least two processing devices are arranged on the base and are used for placing the sample container and processing samples contained in the sample container or recycling the sample container; the first guide piece is fixed with the relative position of the base; and the grabbing and placing device is movably arranged on the first guide piece along the first direction, grabs the sample container at the processing device after moving to the corresponding position of one processing device along the first direction, and loosens the sample container after moving to the corresponding position of the other processing device along the first direction so as to place the sample container at the other processing device. Because the grabbing and placing device is movably arranged on the first guide piece along the first direction and moves along the length direction of the first guide piece, the space occupied by the grabbing and placing device in movement is small, the whole volume of an instrument can be reduced, the miniaturized design of the instrument is facilitated, and the working efficiency can be improved.

The foregoing is only the embodiments of the present application, and not the patent scope of the present application is limited by the foregoing description, but all equivalent structures or equivalent processes using the contents of the present application and the accompanying drawings, or directly or indirectly applied to other related technical fields, which are included in the patent protection scope of the present application.

Claims

1. A sample analyzer, the sample analyzer comprising:

a base;

the at least two processing devices are directly or indirectly arranged on the base and are used for placing a sample container and processing the sample contained in the sample container or recycling the sample container, the at least two processing devices comprise a magnetic separation device, an incubation device and a container recycling device, the magnetic separation device is used for performing magnetic separation processing on the sample in the sample container, the incubation device is used for performing incubation processing on the sample in the sample container, the container recycling device is used for receiving a used sample container, and the position of the incubation device for placing the sample container relative to the base is different from the position of the magnetic separation device for placing the sample container relative to the base;

A first guide fixed in relative position to the base;

the second guide piece is movably arranged on the first guide piece along a first direction, and the first direction is the length direction of the first guide piece;

the grabbing and placing device is movably arranged on the second guide piece along a second direction, the second direction is the length direction of the second guide piece, the second direction is intersected with the first direction, the grabbing and placing device moves to the corresponding position of one of the at least two processing devices along the first direction and grabs the sample container at the processing device after moving to the height of the one processing device for containing the sample container along the second direction on the second guide piece, and the grabbing and placing device moves to the corresponding position of the other of the at least two processing devices along the first direction and loosens the sample container after moving to the height of the other processing device for containing the sample container along the second direction on the second guide piece so as to place the sample container at the other processing device.

2. The sample analyzer of claim 1, further comprising a first fixed plate, the first guide being relatively fixed to the base by the first fixed plate.

3. The sample analyzer of claim 1, further comprising a second fixed plate movably disposed on the first guide in the first direction, the pick and place device being coupled to the second fixed plate.

4. The sample analyzer of claim 1, wherein the first direction is perpendicular to the second direction.

5. The sample analyzer of claim 2, further comprising a container addition device for adding a sample container to the incubation device, the container addition device having a height relative to the base that is greater than a height of the incubation device relative to the base, the first fixation plate being fixed in a position that is higher than the incubation device and higher than the magnetic separation device.

6. The sample analyzer of claim 5, wherein the container adding device comprises at least a bin body and a container channel, the sample container in the bin body is conveyed to the incubation device through the container channel, the container channel comprises a chute and a dispatching disk, the chute is obliquely arranged relative to the bottom surface of the base, a plurality of placing holes are arranged on the dispatching disk, and the axis direction of the placing holes is perpendicular to the bottom wall of the chute.

7. The sample analyzer of claim 1, wherein the position of the incubation device relative to the base at which the sample container is placed is greater than the position of the magnetic separation device relative to the base at which the sample container is placed.

8. The sample analyzer of claim 1, wherein the magnetic separation device comprises a first base and a first turntable rotatably coupled to the first base, at least one first receiving hole is provided in the first turntable, the incubation device comprises a second base and a second turntable rotatably coupled to the second base, at least one second receiving hole is provided in the second turntable, the container recovery device has a receiving channel, and the first receiving hole, the second receiving hole, and the receiving channel are positioned in a line by rotating the first turntable and the second turntable such that the first receiving hole, the second receiving hole, and the receiving channel are positioned in the corresponding positions of the first guide, thereby enabling the gripping device to transfer a sample container between the first receiving hole, the second receiving hole, and the receiving channel.

9. A control method of a sample analyzer for controlling the sample analyzer according to any one of claims 1 to 8, characterized by comprising:

controlling the grabbing and placing device to move to a corresponding position of one of the at least two processing devices along a first direction on the first guide piece, and to move to the height of the sample container held by the one processing device along a second direction on the second guide piece;

controlling the gripping and placing device to grip the sample container at the processing device;

controlling the grabbing and placing device to move to the corresponding position of the other processing device of at least the two processing devices along the first direction on the first guide piece, and moving to the height of the other processing device for containing the sample container along the second direction on the second guide piece;

the pick and place device is controlled to release the sample container to place the sample container at the other processing device.

10. The control method according to claim 9, wherein the at least two processing means include a magnetic separation means for magnetically separating the sample in the sample container and an incubation means for incubating the sample in the sample container.

11. The control method of claim 10, wherein the at least two processing devices further comprise a container recycling device for receiving used sample containers.