CN111375037A - 一种妇科排毒消炎缩阴丸及其制备方法 - Google Patents

一种妇科排毒消炎缩阴丸及其制备方法 Download PDF

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CN111375037A
CN111375037A CN202010324242.1A CN202010324242A CN111375037A CN 111375037 A CN111375037 A CN 111375037A CN 202010324242 A CN202010324242 A CN 202010324242A CN 111375037 A CN111375037 A CN 111375037A
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parts
radix
inflammation
pill
toxin
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马玲玲
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Shanghai Ronggutang Industrial Co ltd
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Shanghai Ronggutang Industrial Co ltd
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Abstract

本发明公开了一种妇科排毒消炎缩阴丸，所述缩阴丸由包括如下重量份的中药材制成：丹参12‑16份，蛇床子12‑16份，苦参12‑16份，藏红花3‑4份，薄荷8‑10份，黄柏8‑10份，一枝黄花8‑10份，百部8‑10份，印尼马都拉山根8‑10份，沙棘8‑10份，紫草籽8‑10份，当归8‑10份，莪术8‑10份，芦荟8‑10份，白芷8‑10份，沉香8‑10份，珍珠粉8‑10份，银杏果8‑10份，白芍8‑10份，冰片4‑5份；并提供了其制备方法。该缩阴丸为纯中药制剂，具有排毒消炎的功效，可明显改善月经不调、痛经、妇科炎症等常见症，去腐生肌，激活字样细胞，促进女性私处恢复紧致状态，使用方便，起效快，不破坏内环境酸碱平衡，无副作用，不反弹。

Description

一种妇科排毒消炎缩阴丸及其制备方法
技术领域
本发明属于妇科药物技术领域，具体地，涉及一种妇科排毒消炎缩阴丸及其制备方法。
背景技术
女性因生育及衰老会导致私处松弛干涩的问题。正常的女性阴道宽度为2.5厘米左右，在自然分娩过程中，胎儿经过阴道分娩时，阴道会明显变宽，正常出生婴儿的头径在10厘米左右，所以分娩时女性阴道宽度会扩张到10厘米左右。即使是选择剖腹产的女性，在临产时盆腔的肌肉和韧带都会延伸，也会导致阴道松弛。除此之外，因为性生活及随着年龄增长的身体衰老原因，私处也会出现松弛干燥等问题。宫寒、痛经、月经不调、炎症等也是常见的妇科疾病。
市面上的很多私护产品大部分都是西药成分组成，作用多为清洁消炎，使用不当会导致私处pH值的破坏，酸碱不平衡，使私处免疫力越来越低，从而引发各种妇科问题的发生，而且停止用药后容易出现反弹的情况。
发明内容
本发明的第一个目的是解决上述问题，提供一种妇科排毒消炎缩阴丸，丸剂为纯中药制剂，无明显异味，无副作用，起效快，可明显改善女性阴道松弛症状，对常见妇科炎症等也有良好的治疗效果。
本发明的第二个目的是提供上述缩阴丸的制备方法。
本发明的目的通过以下技术方案来具体实现：
一种妇科排毒消炎缩阴丸，所述缩阴丸由包括如下重量份的中药材制成：
丹参12-16份，蛇床子12-16份，苦参12-16份，藏红花3-4份，薄荷8-10份，黄柏8-10份，一枝黄花8-10份，百部8-10份，印尼马都拉山根8-10份，沙棘8-10份，紫草籽8-10份，当归8-10份，莪术8-10份，芦荟8-10份，白芷8-10份，沉香8-10份，珍珠粉8-10份，银杏果8-10份，白芍8-10份，冰片4-5份。
作为优选的，所述缩阴丸由以下重量份的中药材制成：
丹参14份，蛇床子14份，苦参14份，藏红花4份，薄荷9份，黄柏9份，一枝黄花9份，百部9份，印尼马都拉山根9份，沙棘9份，紫草籽9份，当归9份，莪术9份，芦荟9份，白芷9份，沉香9份，珍珠粉9份，银杏果9份，白芍9份，冰片4份。
上述任一项所述的妇科排毒消炎缩阴丸的制备方法，包括以下步骤：
(1)中药材的预处理，将丹参、蛇床子、苦参、藏红花、薄荷、黄柏、一枝黄花、百部、印尼马都拉山根、沙棘、紫草籽、当归、莪术、白芷、沉香、银杏果、白芍粉碎，过筛，芦荟捣烂成糊状；
(2)水提，将步骤(1)预处理后的中药材用水加热提取两次，两次提取的提取液合并，得水提取液；
(3)醇提，将冰片和步骤(2)水提后的中药渣用乙醇回流提取，上清液加热浓缩回收乙醇至溶液粘稠，得醇提取液；
(4)珍珠水解，珍珠粉在酸性条件下进行水解，得水解珍珠液；
(5)制丸，将步骤(2)得到的水提取液、步骤(3)得到的醇提取液和步骤(4)得到的水解珍珠液混合，加热浓缩至半固态时，制丸，然后进行烘干，即得。
作为优选的，步骤(1)中，过筛的筛孔为2mm。
作为优选的，步骤(2)的水提方法为：将步骤(1)预处理后的中药材加入2倍重量的水中，加热至95-100℃，提取3h，过滤收集滤液，共提取两次，滤液合并。
作为优选的，步骤(3)的醇提方法为：中药渣中加入的乙醇量为步骤(1)的中药材重量的1.5倍，回流时间为2h，乙醇的体积分数为95vt％。
作为优选的，步骤(4)的珍珠水解方法为：将珍珠粉加入3倍重量的水中，用醋酸调节pH至4.4-4.6，加热至60℃，以30rpm的转速搅拌3h。
作为优选的，步骤(5)加热浓缩的温度为80℃，烘干温度为60℃。
丹参，性寒，味苦，归心、肝经，具有活血调经、祛瘀止痛、凉血消痈、清心除烦、养血安神的功效，可用于治疗月经不调、闭经痛经、症瘕积聚等症。
蛇床子，性温，味辛、苦，归肾经，具有温肾壮阳，燥湿、祛风、杀虫的功效，可用于治疗阳痿、宫冷、寒湿带下、湿痹腰痛，外治外阴湿疹、妇人阴痒、滴虫性阴道炎等症。
苦参，性寒，味苦，归小肠、肝、肾、大肠经，具有清热燥湿、祛风杀虫的功效，可用于治疗湿热泻痢、肠风便血、黄疸；小便不利、水肿、带下、阴痒、疥癣、麻风、皮肤瘙痒、湿毒疮疡等症。
藏红花，性平，味甘，归心、肝经，具有活血化瘀、凉血解毒、解郁安神的功效，可用于治疗经闭症瘕、产后瘀阻、温毒发斑、忧郁痞闷、惊悸发狂等症。
薄荷，性凉，味辛，归肺、肝经，具有疏风、散热、辟秽、解毒的功效，可用于治疗外感风热、头痛、目赤、咽喉肿痛、食滞气胀、口疮、牙痛、疮疥、瘾疹等症。
黄柏，性寒，味苦，归肾、膀胱经，具有清热燥湿、泻火解毒的功效，可用于治疗湿热痢疾、泄泻、黄疸；梦遗、淋浊、带下、骨蒸劳热、以及口舌生疮、目赤肿痛、痈疽疮毒、皮肤湿疹等症。
一枝黄花，性凉，味辛、苦，归胆、肝经，具有疏风清热、消肿解毒的功效，可用于治疗感冒头痛、咽喉肿痛、黄疸、百日咳、小儿惊风、跌打损伤、痈肿发背、鹅掌风等症。
百部，性温，味甘、苦，归肺经，具有润肺止咳、杀虫灭虱的功效，可用于治疗新久咳嗽、肺痨、百日咳、蛲虫病、体虱、癣疥等症。
印尼马都拉山根，具有杀菌排毒、消除阴道堆积的毒素和修复女性私处弹性纤维的功效。
沙棘，性温，微酸、涩，具有止咳化痰、健胃消食、活血散瘀的功效，可用于治疗咳嗽痰多、肺脓肿、消化不良、食积腹痛、胃痛、肠炎、闭经、跌打瘀肿等症。
紫草籽，具有凉血止血、清热解毒、清热利湿、泻火通便的功效，可用于治疗吐血、衄血、尿血、血痢、丹毒、痈疡、湿疹、大便干结、小便短赤等症。
当归，性温，味辛、甘，归心、脾、肝经，具有补血和血、调经止痛、润燥滑肠的功效，可用于治疗月经不调、经闭腹痛、症瘕结聚、崩漏、血虚头痛、眩晕、痿痹、肠燥便难、赤痢后重、痈疽疮窃、跌扑损伤等症。
莪术，性温、味辛、苦，归脾、肝经，具有行气破血、消积止痛的功效，可用于治疗燀瘕痞块、瘀血经闭、食积胀痛、早期宫颈癌等症。
芦荟，性寒，味苦，归肝、大肠经，具有清肝热、通便的功效，可用于治疗便秘、小儿疳积、惊风、外治湿癣等症。
白芷，性温，味辛，归胃、肺、脾经，具有散风除湿、通窍止痛、消肿排脓的功效，可用于治疗感冒头痛、眉棱骨痛、鼻塞、鼻渊、牙痛、白带、疮疡肿痛等症。
沉香，性温，味辛、苦，归胃、脾、肾经，具有行气止痛、温中止呕、纳气平喘的功效，可用于治疗胸腹胀闷疼痛、胃寒呕吐呃逆、肾虚气逆喘急等症。
珍珠粉，具有安神定惊、明目去翳、解毒生肌等功效，在提高人体免疫力、延缓衰老、祛斑美白、补充钙质等方面都具有独特的作用。
银杏果，性平，味甘、苦、涩，归肺经，具有敛肺定喘、止带浊、缩小便的功效，可用于治疗痰多喘咳、带下白浊、遗尿尿频等症。
白芍，性微寒，味苦、酸，归肝、脾经，具有养血调经、敛阴止汗、柔肝止痛、平抑肝阳的功效，可用于治疗血虚萎黄、月经不调、自汗、盗汗、胁痛、腹痛、四肢挛痛、头痛眩晕等症。
冰片，性凉，味辛、苦，归心、肺经，具有开窍醒神、清热止痛的功效，可用于治疗热病神昏、痉厥、中风痰厥、气郁暴厥、中恶昏迷、目赤、口疮、咽喉肿痛、耳道流脓等症。
本发明的缩阴丸无激素，非抗生素杀菌，无任何添加剂、防腐剂等化学成分；能够抗菌、抑菌、杀菌，促进有益菌繁殖，抗氧化，抗衰老，抗病原，双向强化免疫力，调节HPV值，抗病毒，调节内分泌，增强自愈力；排阴毒、积液浊水、重金属，同时可做妇科自检；改善宫寒痛经，清热祛湿，月经不正常，淡斑；调节机能，修复盆底肌；清宫，消炎，止痒，祛异味，去腐生肌，只针对非正常组织进行排出，促进凝血和伤口愈合并修复；养卵护巢，防止卵巢早衰，改善雌性激素分泌，激活机体系统，激活荷尔蒙，调理气血运行；激活滋养细胞，促进女性私处恢复紧致；纯中药制剂，根据君臣佐使配伍，不破坏内环境的酸碱平衡，无副作用，无依赖，不反弹；浓缩中药精华，无残渣，吸收快，无浓重中药味，不尴尬；起效快，当天使用后即可改善性冷淡，增加性快感；使用方便，中药丸用温水溶解后直接作用于私处。
本发明具有以下有益效果：
本发明提供的妇科排毒消炎缩阴丸为纯中药制剂，具有排毒消炎的功效，可明显改善月经不调、痛经、妇科炎症等常见症，去腐生肌，激活字样细胞，促进女性私处恢复紧致状态，使用方便，起效快，不破坏内环境酸碱平衡，无副作用，不反弹。
具体实施方式
实施例1
一种纯中药缩阴丸，制备方法如下：
(1)将丹参1.2kg、蛇床子1.2kg、苦参1.2kg、藏红花0.3kg、薄荷0.8kg、黄柏0.8kg、一枝黄花0.8kg、百部0.8kg、印尼马都拉山根0.8kg、沙棘0.8kg、紫草籽0.8kg、当归0.8kg、莪术0.8kg、白芷0.8kg、沉香0.8kg、银杏果0.8kg、白芍0.8kg粉碎，过2mm筛，芦荟0.8kg捣烂成糊状。
(2)将步骤(1)预处理后的中药材用水加热提取两次，每次水的用量为中药材重量的2倍，加热至95-100℃，保持3h，过滤收集滤液，滤液合并，得水提取液。
(3)将冰片0.4kg和步骤(2)水提后的中药渣用体积分数95％乙醇回流提取2h，乙醇用量为步骤(1)中药材重量的1.5倍，上清液加热浓缩回收乙醇至溶液粘稠，得醇提取液。
(4)珍珠粉0.8kg加3倍重量的水，用醋酸调节pH至4.4-4.6，加热至60℃，以30rpm的转速搅拌3h，得水解珍珠液。
(5)将上面得到的水提取液、醇提取液和水解珍珠液混合，加热至80℃浓缩至半固态时，制成2mm直径的药丸，然后在60℃下烘干，即得。
实施例2
一种纯中药缩阴丸，制备方法如下：
(1)将丹参1.4kg、蛇床子1.4kg、苦参1.4kg、藏红花0.4kg、薄荷0.9kg、黄柏0.9kg、一枝黄花0.9kg、百部0.9kg、印尼马都拉山根0.9kg、沙棘0.9kg、紫草籽0.9kg、当归0.9kg、莪术0.9kg、白芷0.9kg、沉香0.9kg、银杏果0.9kg、白芍0.9kg粉碎，过2mm筛，芦荟0.9kg捣烂成糊状。
(2)将步骤(1)预处理后的中药材用水加热提取两次，每次水的用量为中药材重量的2倍，加热至95-100℃，保持3h，过滤收集滤液，滤液合并，得水提取液。
(3)将冰片0.4kg和步骤(2)水提后的中药渣用体积分数95％乙醇回流提取2h，乙醇用量为步骤(1)中药材重量的1.5倍，上清液加热浓缩回收乙醇至溶液粘稠，得醇提取液。
(4)珍珠粉0.9kg加3倍重量的水，用醋酸调节pH至4.4-4.6，加热至60℃，以30rpm的转速搅拌3h，得水解珍珠液。
(5)将上面得到的水提取液、醇提取液和水解珍珠液混合，加热至80℃浓缩至半固态时，制成2mm直径的药丸，然后在60℃下烘干，即得。
实施例3
一种纯中药缩阴丸，制备方法如下：
(1)将丹参1.6kg、蛇床子1.6kg、苦参1.6kg、藏红花0.4kg、薄荷1.0kg、黄柏1.0kg、一枝黄花1.0kg、百部1.0kg、印尼马都拉山根1.0kg、沙棘1.0kg、紫草籽1.0kg、当归1.0kg、莪术1.0kg、白芷1.0kg、沉香1.0kg、银杏果1.0kg、白芍1.0kg粉碎，过2mm筛，芦荟1.0kg捣烂成糊状。
(2)将步骤(1)预处理后的中药材用水加热提取两次，每次水的用量为中药材重量的2倍，加热至95-100℃，保持3h，过滤收集滤液，滤液合并，得水提取液。
(3)将冰片0.5kg和步骤(2)水提后的中药渣用体积分数95％乙醇回流提取2h，乙醇用量为步骤(1)中药材重量的1.5倍，上清液加热浓缩回收乙醇至溶液粘稠，得醇提取液。
(4)珍珠粉1.0kg加3倍重量的水，用醋酸调节pH至4.4-4.6，加热至60℃，以30rpm的转速搅拌3h，得水解珍珠液。
(5)将上面得到的水提取液、醇提取液和水解珍珠液混合，加热至80℃浓缩至半固态时，制成2mm直径的药丸，然后在60℃下烘干，即得。
缩阴效果试验
1.试验人员：根据自愿原则选取90位女性，年龄32-45岁之间，均有阴道松弛问题。其中33位生育一胎，其余57位生育二胎，随机分为三组，每组30人。
2.试验药物：实施例1-3的缩阴丸。
3.试验方法：三组试验人员分别使用实施例1-3的药物，每日用缩阴丸10g，加入80℃以上的水溶解，用溶液清洗私处，可选择坐浴或淋洗的方法，10日一个疗程，共进行两个疗程。
4.疗效判定标准
两个疗程后采用回访的方法对试验人员进行调查，让试验人员根据自己的使用情况对效果进行评判，效果分为明显、较好、一般、无效。结果见表1。
表1缩阴效果试验
组别 明显 较好 一般 无效 有效率/％
实施例1 12 7 6 5 83.3％
实施例2 15 8 5 2 93.3％
实施例3 12 10 5 3 90％
妇科症效果试验
1.试验人员：根据自愿原则选取150位女性，年龄23-51岁之间，均有不同程度的常见妇科症，主要表现为外阴瘙痒、异味、痛经等。随机分为三组，每组50人。
2.试验药物：实施例1-3的缩阴丸。
3.试验方法：三组试验人员分别使用实施例1-3的药物，每日用缩阴丸10g，加入80℃以上的水溶解，用溶液清洗私处，可选择坐浴或淋洗的方法，7日一个疗程，共进行两个疗程。
4.疗效判定标准
两个疗程后采用回访的方法对试验人员进行调查，让试验人员根据自己的使用情况对效果进行评判，效果分为明显、较好、一般、无效。结果见表2。
表2妇科症效果试验
组别 明显 较好 一般 无效 有效率/％
实施例1 31 13 4 2 96％
实施例2 36 11 3 0 100％
实施例3 34 11 3 2 96％
对上面进行的缩阴效果试验人员和妇科症效果试验人员回访时随机选择60位调查了对性生活的效果，56位试验人员认为对性生活有改善作用，性快感增强，使用后当天即表现出效果。
以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (8)

1.一种妇科排毒消炎缩阴丸，其特征在于，所述缩阴丸由包括如下重量份的中药材制成：
丹参12-16份，蛇床子12-16份，苦参12-16份，藏红花3-4份，薄荷8-10份，黄柏8-10份，一枝黄花8-10份，百部8-10份，印尼马都拉山根8-10份，沙棘8-10份，紫草籽8-10份，当归8-10份，莪术8-10份，芦荟8-10份，白芷8-10份，沉香8-10份，珍珠粉8-10份，银杏果8-10份，白芍8-10份，冰片4-5份。
2.根据权利要求1所述的妇科排毒消炎缩阴丸，其特征在于，所述缩阴丸由以下重量份的中药材制成：
丹参14份，蛇床子14份，苦参14份，藏红花4份，薄荷9份，黄柏9份，一枝黄花9份，百部9份，印尼马都拉山根9份，沙棘9份，紫草籽9份，当归9份，莪术9份，芦荟9份，白芷9份，沉香9份，珍珠粉9份，银杏果9份，白芍9份，冰片4份。
3.权利要求1或2所述的妇科排毒消炎缩阴丸的制备方法，其特征在于，包括以下步骤：
(1)中药材的预处理，将丹参、蛇床子、苦参、藏红花、薄荷、黄柏、一枝黄花、百部、印尼马都拉山根、沙棘、紫草籽、当归、莪术、白芷、沉香、银杏果、白芍粉碎，过筛，芦荟捣烂成糊状；
(2)水提，将步骤(1)预处理后的中药材用水加热提取两次，两次提取的提取液合并，得水提取液；
(3)醇提，将冰片和步骤(2)水提后的中药渣用乙醇回流提取，上清液加热浓缩回收乙醇至溶液粘稠，得醇提取液；
(4)珍珠水解，珍珠粉在酸性条件下进行水解，得水解珍珠液；
(5)制丸，将步骤(2)得到的水提取液、步骤(3)得到的醇提取液和步骤(4)得到的水解珍珠液混合，加热浓缩至半固态时，制丸，然后进行烘干，即得。
4.根据权利要求3所述的妇科排毒消炎缩阴丸的制备方法，其特征在于，步骤(1)中，过筛的筛孔为2mm。
5.根据权利要求3所述的妇科排毒消炎缩阴丸的制备方法，其特征在于，步骤(2)的水提方法为：将步骤(1)预处理后的中药材加入2倍重量的水中，加热至95-100℃，提取3h，过滤收集滤液，共提取两次，滤液合并。
6.根据权利要求3所述的妇科排毒消炎缩阴丸的制备方法，其特征在于，步骤(3)的醇提方法为：中药渣中加入的乙醇量为步骤(1)的中药材重量的1.5倍，回流时间为2h，乙醇的体积分数为95vt％。
7.根据权利要求3所述的妇科排毒消炎缩阴丸的制备方法，其特征在于，步骤(4)的珍珠水解方法为：将珍珠粉加入3倍重量的水中，用醋酸调节pH至4.4-4.6，加热至60℃，以30rpm的转速搅拌3h。
8.根据权利要求3所述的妇科排毒消炎缩阴丸的制备方法，其特征在于，步骤(5)加热浓缩的温度为80℃，烘干温度为60℃。
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CN108853311A (zh) * 2018-09-19 2018-11-23 怡仁康药业（深圳）有限公司 一种用于阴道粘膜抑菌的中药凝胶组合物

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CN104288489A (zh) * 2014-09-27 2015-01-21 张乔木 一种用于治疗乳腺肿瘤的药物及其制备方法
CN104998160A (zh) * 2015-07-17 2015-10-28 郭芝学 一种妇科洗液
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