CN111366441A - Tablet-making dyeing machine - Google Patents
Tablet-making dyeing machine Download PDFInfo
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- CN111366441A CN111366441A CN202010280908.8A CN202010280908A CN111366441A CN 111366441 A CN111366441 A CN 111366441A CN 202010280908 A CN202010280908 A CN 202010280908A CN 111366441 A CN111366441 A CN 111366441A
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- 238000004043 dyeing Methods 0.000 title claims abstract description 71
- 230000007246 mechanism Effects 0.000 claims abstract description 243
- 239000007788 liquid Substances 0.000 claims abstract description 83
- 238000002347 injection Methods 0.000 claims abstract description 44
- 239000007924 injection Substances 0.000 claims abstract description 44
- 239000002699 waste material Substances 0.000 claims description 43
- 239000000463 material Substances 0.000 claims description 20
- 230000000712 assembly Effects 0.000 claims description 18
- 238000000429 assembly Methods 0.000 claims description 18
- 238000010186 staining Methods 0.000 claims description 18
- 230000001360 synchronised effect Effects 0.000 claims description 14
- 230000005540 biological transmission Effects 0.000 claims description 13
- 238000003825 pressing Methods 0.000 claims description 9
- 238000011084 recovery Methods 0.000 claims description 8
- 238000009434 installation Methods 0.000 claims description 6
- 230000005484 gravity Effects 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 4
- 238000012546 transfer Methods 0.000 abstract description 7
- 230000009471 action Effects 0.000 description 19
- 238000002360 preparation method Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
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- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Treatment Of Fiber Materials (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a slice-making dyeing machine, which comprises an ㄈ type frame, an X-axis sliding mechanism, a Y-axis sliding mechanism, a liquid-transferring mechanism, an injection mechanism, a feeding mechanism, a centrifugal mechanism, a dyeing mechanism and an operating device, wherein the X-axis sliding mechanism is arranged on the frame; the Y-axis sliding mechanism is arranged at the upper part of the ㄈ -shaped frame, and the X-axis sliding mechanism is connected with the Y-axis sliding mechanism in a sliding manner; the liquid transfer mechanism is arranged on the left side of the X-axis sliding mechanism and is connected with the X-axis sliding mechanism in a sliding manner; the injection mechanism is arranged on the right side of the X-axis sliding mechanism; the feeding mechanism is arranged on the vertical part of the model ㄈ rack and is communicated with the pipetting mechanism and the injection mechanism; the bottom of the ㄈ type frame is provided with a working platform, and the centrifugal mechanism, the dyeing mechanism and the control device are sequentially arranged on the working platform from left to right. The liquid-transferring mechanism and the injection mechanism can accurately move to required stations, injection liquid and specimen transfer are completed mechanically, labor cost is saved, automatic sheet making is realized, and sheet making efficiency is high.
Description
Technical Field
The invention relates to the technical field of liquid-based cell preparation, in particular to a tablet preparation dyeing machine.
Background
Currently, in clinical medicine, the existence of pathological changes in a human body is often judged by observing cell slices of various tissues of the human body. With the rapid development of science and technology and social economy, the development of pathological analysis technology is greatly promoted, so that the second generation liquid-based cell slide preparation technology represented by the sedimentation type liquid-based cell slide preparation technology is more and more widely applied to the preparation of cytopathology specimens.
In the prior art, the process of preparing a liquid-based cytology slice comprises: sampling, centrifuging, smearing and dyeing, sample transfer and injection slide making required liquid are also finished manually, automation cannot be realized, and the slide making efficiency is low; the present invention has been developed based on this.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a tablet-making and dyeing machine.
The technical scheme of the invention is as follows: a tablet-making and dyeing machine comprising: ㄈ type frame, X-axis sliding mechanism, Y-axis sliding mechanism, liquid-transferring mechanism, injection mechanism, feeding mechanism, centrifugal mechanism, dyeing mechanism and control device which are matched with the liquid-transferring mechanism and the injection mechanism; the Y-axis sliding mechanism is arranged at the upper part of the ㄈ -type framework, and the X-axis sliding mechanism is connected with the Y-axis sliding mechanism in a sliding manner and can slide left and right along the Y-axis direction of the Y-axis sliding mechanism; the pipetting mechanism is arranged on the left side of the X-axis sliding mechanism, is connected with the X-axis sliding mechanism in a sliding manner and can slide back and forth along the X-axis direction of the X-axis sliding mechanism; the injection mechanism is arranged on the right side of the X-axis sliding mechanism; the feeding mechanism is arranged on the vertical part of the model ㄈ rack and is communicated with the pipetting mechanism and the injection mechanism; the bottom of the ㄈ -type frame is provided with a working platform, and the centrifugal mechanism, the dyeing mechanism and the control device are sequentially arranged on the working platform from left to right; the control device is respectively electrically connected with the X-axis sliding mechanism, the Y-axis sliding mechanism, the liquid transferring mechanism, the injection mechanism, the feeding mechanism and the centrifugal mechanism and is used for controlling the operation of equipment.
Preferably, the centrifugal mechanism comprises a shell, a power mechanism, a rotating mechanism and a plurality of centrifugal pipe frames; the shell comprises a top cover and a bottom frame which can be separated, the top cover is arranged above the bottom frame, and a centrifugal cavity is arranged in the bottom frame; the rotating mechanism is arranged below the working platform, and the top of the rotating mechanism sequentially penetrates out of the working platform and the bottom frame upwards and is placed in the centrifugal cavity; the plurality of centrifuge tube racks are rotatably arranged at the top of the rotating mechanism, each centrifuge tube rack is uniformly provided with a plurality of tube holes, and a centrifuge tube is arranged in each tube hole; the power mechanism is arranged below the working platform at one side of the rotating mechanism and is connected with the rotating mechanism;
the centrifugal mechanism also comprises a waste material barrel and a waste liquid groove; waste bucket and waste liquid groove in set gradually on work platform after to in the past between casing and the dyeing mechanism, the waste bucket is used for retrieving the centrifuging tube, the waste liquid groove is used for retrieving centrifugal waste liquid.
Preferably, the rotating mechanism consists of a supporting seat, a rotating bracket and a pressing plate; the supporting seat can be rotatably arranged below the working platform around the axis of the supporting seat, the bottom of the supporting seat is connected with the power mechanism, and the top of the supporting seat sequentially penetrates out of the working platform and the bottom frame upwards and is arranged in the centrifugal cavity; the rotating bracket is fixedly arranged at the top of the supporting seat, the rotating bracket is uniformly provided with a plurality of mounting bins matched with the number of the centrifuge tube racks, and the centrifuge tube racks can be rotatably arranged in each mounting bin; the clamp plate in centrifuge tube rack top install in on the runing rest, just the clamp plate corresponds every the position in installation storehouse is equipped with protruding finger, every centrifuge tube rack in the installation storehouse corresponds the position of protruding finger is equipped with the draw-in groove.
Preferably, the power mechanism comprises a servo motor provided with an encoder, a transmission gear, a synchronous belt and a rotating gear; the rotating gear is fixedly arranged at the bottom of the supporting seat; the servo motor is arranged on one side of the rotating gear; the transmission gear is fixedly arranged on an output shaft of the servo motor; the synchronous belt is arranged on the transmission gear and the rotating gear;
the power mechanism also comprises two fastening devices; the two tightening devices are respectively arranged below the bottom frame at two sides of the synchronous belt and used for adjusting the tightness of the synchronous belt;
the bottom of each centrifuge tube rack is provided with a gravity pressing block;
the top cover is provided with a cover plate accommodating groove, and a cover plate is arranged in the cover plate accommodating groove; handles are arranged on two sides of the cover plate respectively and used for grabbing the cover plate; the cover plate is also provided with an observation window between the two handles.
Preferably, the staining mechanism comprises a number of slide staining assemblies and a carrier; the bracket is arranged on the working platform; a plurality of slide staining assemblies disposed on the carrier;
the dyeing mechanism further comprises a recovery tank for recovering waste liquid; the recovery tank is arranged on the working platform at the right side of the bracket;
the dyeing mechanism further comprises a recovery barrel for recovering waste materials; the recycling bin is arranged on the working platform at the rear side of the bracket;
each of the slide staining assemblies includes:
the dyeing bottle is hollow, the bottom of the dyeing bottle is provided with an annular bulge and a rubber ring, and two opposite sides of the annular bulge are respectively extended with a lug;
the glass slide dyeing device comprises a carrier plate, a plurality of dyeing bottles and a plurality of dyeing pieces, wherein the carrier plate is provided with grooves which are arranged in an array manner and are used for accommodating glass slides, and two inner sides of each groove are provided with buckling positions for buckling annular raised bumps at the bottom of each dyeing bottle;
wherein, the two sides of the carrier plate are provided with handles for transferring the carrier plate.
Preferably, the X-axis sliding mechanism comprises an X-axis slide rail, a first motor arranged at an end of the X-axis slide rail, and a chain arranged at an output end of the first motor; the chain is arranged on the track of the X-axis slide rail and can slide back and forth along the track of the X-axis slide rail; the liquid-transfering mechanism is arranged on the chain and can slide back and forth on the X-axis slide rail along the chain to move.
Preferably, the Y-axis sliding mechanism comprises a Y-axis slide rail, a slide block connected with the Y-axis slide rail in a sliding manner, and a belt-type conveying mechanism for providing power for the slide block;
the belt type conveying mechanism comprises a second motor, a driving wheel connected with the output end of the second motor, a driven wheel matched with the driving wheel, and belts arranged on the driving wheel and the driven wheel; the slider is arranged on the belt.
Preferably, the pipetting mechanism comprises a first pipetting assembly, a first pipetting groove matched with the first pipetting assembly, a second pipetting groove matched with the second pipetting assembly, a specimen groove and a connecting plate; the connecting plate is arranged on the chain and can slide back and forth on the X-axis slide rail along the chain to move; the first pipetting assembly and the second pipetting assembly are sequentially arranged on the connecting plate from front to back and are respectively used for pipetting;
the first pipetting assembly comprises a third motor and a first pipetting gun connected with the output end of the third motor; the first liquid-transferring gun is also communicated with the feeding mechanism through a material pipe; the first liquid transferring groove is arranged on the working platform at the front side of the centrifugal mechanism, and a plurality of first liquid transferring pipes matched with the first liquid transferring gun are arranged in the first liquid transferring groove;
the second pipetting assembly comprises a fourth motor and a second pipetting gun connected with the output end of the fourth motor; the second liquid-transferring gun is also communicated with the feeding mechanism through a material pipe; the second liquid transferring groove is arranged on the working platform at the front side of the waste barrel, and a plurality of second liquid transferring pipes matched with the second liquid transferring gun are arranged in the second liquid transferring groove;
the specimen liquid tank is arranged on the working platform between the second liquid transferring tank and the dyeing mechanism, and a plurality of specimen liquid tubes are placed in the specimen liquid tank.
Preferably, the injection mechanism comprises a mounting frame, a fifth motor arranged on the mounting frame, a support plate connected with the output end of the fifth motor, and a plurality of injection assemblies matched with grooves arranged in an array on the support plate; the mounting frame is arranged on the right side of the X-axis slide rail, and each injection assembly is arranged on the supporting plate at a position corresponding to a row of grooves on the carrier plate respectively;
each injection assembly comprises a plurality of groups of dyeing needles and a group of waste liquid needles, and the length of each waste liquid needle is greater than that of each group of dyeing needles; each group of dyeing needles is respectively communicated with the feeding mechanism through a material pipe; the waste liquid needle is used for sucking out waste liquid.
Preferably, the feeding mechanism comprises a plurality of pressure pumps matched with the first liquid-transferring gun, the second liquid-transferring gun and a plurality of injection assemblies; each pressure pump is externally connected with a liquid storage device, the first liquid-transferring gun is communicated with one of the pressure pumps through a material pipe, the second liquid-transferring gun is communicated with one of the pressure pumps through a material pipe, and the dyeing needle of each injection assembly is correspondingly communicated with one of the pressure pumps through the material pipe.
By adopting the scheme, the invention has the following beneficial effects:
1. the design of the invention ensures that the liquid transfer mechanism and the injection mechanism can accurately move to the required stations, the injection liquid and the specimen transfer are completed mechanically, the labor cost is saved, the automatic sheet making is realized, and the sheet making efficiency is high;
2. in the preferred scheme, the swing direction and angle of the centrifugal tube are controlled in the centrifugal process, the damage of the centrifugal tube caused by collision is effectively avoided, the integrity of the centrifugal tube is ensured, the centrifugal effect is good, and the use experience is good;
3. the encoder in the preferred scheme is applied, so that the number of turns of the servo motor rotating during each work is effectively ensured to be a fixed value, and the function of positioning the centrifuge tube rack is realized;
4. the application of the tightening device in the optimized scheme can effectively regulate and control the tightness of the synchronous belt, and ensures the transmission accuracy.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the present invention with the top of the frame removed;
FIG. 3 is an enlarged view taken at A in FIG. 2;
FIG. 4 is a schematic structural view of an X-axis, Y-axis slide mechanism and an injection mechanism of the present invention;
FIG. 5 is a schematic structural view of a centrifugal mechanism according to the present invention;
FIG. 6 is a schematic view of a centrifugal mechanism of the present invention with a housing removed;
FIG. 7 is a schematic view of a rotating assembly of the centrifugal mechanism of the present invention;
FIG. 8 is a schematic view of the dyeing assembly of the present invention;
FIG. 9 is an enlarged view of FIG. 8 at B;
FIG. 10 is a top view of a staining bottle of the present invention;
FIG. 11 is a bottom view of the staining bottle of the present invention.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
The invention is described in detail below with reference to the figures and the specific embodiments.
Referring to fig. 1 to 11, the present invention provides a tablet-making and dyeing machine, which includes an ㄈ -type frame 1, an X-axis sliding mechanism 2, a Y-axis sliding mechanism 3, a pipetting mechanism 4, an injection mechanism 5, a feeding mechanism 6, a centrifuging mechanism 7, a dyeing mechanism 8 and a control device 9, wherein the feeding mechanism is matched with the pipetting mechanism 4 and the injection mechanism 5; the Y-axis sliding mechanism 3 is arranged at the upper part of the ㄈ -type machine frame 1, and the X-axis sliding mechanism 2 is connected with the Y-axis sliding mechanism 3 in a sliding manner and can slide left and right along the Y-axis direction of the Y-axis sliding mechanism 3; the liquid-transferring mechanism 4 is arranged on the left side of the X-axis sliding mechanism 2, is connected with the X-axis sliding mechanism 2 in a sliding manner, and can slide back and forth along the X-axis direction of the X-axis sliding mechanism 2, and the liquid-transferring mechanism 4 is arranged on the X-axis sliding mechanism 2 and further can slide left and right along the Y-axis direction of the Y-axis sliding mechanism 3; the injection mechanism 5 is arranged on the right side of the X-axis sliding mechanism 2 corresponding to the dyeing mechanism 8; the feeding mechanism 6 is arranged at the vertical part of the ㄈ type rack 1 and is communicated with the pipetting mechanism 4 and the injection mechanism 5 through a material pipe; the bottom of the ㄈ -type frame 1 is provided with a working platform, and the centrifugal mechanism 7, the dyeing mechanism 8 and the control device 9 are sequentially arranged on the working platform from left to right; the control device 9 is respectively electrically connected with the X-axis sliding mechanism 2, the Y-axis sliding mechanism 3, the liquid-transferring mechanism 4, the injection mechanism 5, the feeding mechanism 6 and the centrifugal mechanism 7 and is used for controlling the operation of the equipment.
The centrifugal mechanism 7 comprises a shell 71, a power mechanism 72, a rotating mechanism 73 and a plurality of centrifugal pipe frames 74; the shell 71 comprises a top cover 711 and a bottom frame 712 which can be separated, the top cover 711 is arranged above the bottom frame 712, and a centrifugal cavity is arranged in the bottom frame 712; the rotating mechanism 73 is arranged below the working platform, and the top of the rotating mechanism 73 sequentially penetrates out of the working platform and the bottom frame 712 and is placed in the centrifugal cavity; the plurality of centrifuge tube racks 74 are rotatably mounted at the top of the rotating mechanism 73, each centrifuge tube rack 74 is uniformly provided with a plurality of tube holes, and a centrifuge tube is placed in each tube hole; the power mechanism 72 is arranged below the working platform at one side of the rotating mechanism 73, the power mechanism 72 is connected with the rotating mechanism 73, when in use, the power mechanism 72 drives the rotating mechanism 73 to rotate around the axis of the power mechanism, and the rotating mechanism 73 drives the plurality of centrifuge tube racks 74 connected with the power mechanism to rotate, so that centrifugal processing of the centrifuge tubes is completed;
the rotating mechanism 73 is composed of a supporting seat 731, a rotating bracket 732 and a pressing plate 733; the supporting seat 731 can rotate around the axis of the supporting seat 731 and is arranged below the working platform, the bottom of the supporting seat 731 is connected with the power mechanism 72, and the top of the supporting seat 731 sequentially penetrates out of the working platform and the bottom frame 712 and is arranged in the centrifugal cavity; the rotating bracket 732 is fixedly installed at the top of the supporting seat 731, and the rotating bracket 732 is uniformly provided with a plurality of installation bins 7321 matched with the centrifuge tube racks 74 in number, and the centrifuge tube racks 74 are rotatably installed in each installation bin 7321; the pressing plate 733 is mounted on the rotating support 732 above the centrifuge tube rack 74, a convex finger 7331 is arranged at the position of the pressing plate 733 corresponding to each mounting bin 7321, a clamping groove is arranged at the position of the centrifuge tube rack 74 in each mounting bin 7321 corresponding to the convex finger 7331, and when the centrifuge tube rack is used, the convex finger 7331 and the clamping groove are used for limiting the centrifuge tube rack 74, so that the swing direction and angle of the centrifuge tube rack 74 in the centrifugal process are controlled, collision between centrifuge tubes on two oppositely arranged centrifuge tube racks 74 is effectively avoided, and the integrity of the centrifuge tubes is ensured;
the power mechanism 72 comprises a servo motor 721 provided with an encoder, a transmission gear 722, a synchronous belt 723 and a rotary gear 724; the rotating gear 724 is fixedly arranged at the bottom of the supporting seat 731; the servo motor 721 is installed at one side of the rotary gear 724; the transmission gear 722 is fixedly mounted on an output shaft of the servo motor 721; the synchronous belt 723 is arranged on the transmission gear 722 and the rotating gear 724; when in use, the servo motor 721 drives the transmission gear 722 connected with the servo motor to rotate, the transmission gear 722 drives the rotating gear 724 to rotate through the synchronous belt 723, and the rotating gear 724 drives the supporting seat 731 connected with the rotating gear to rotate around the axis of the rotating gear 724;
it should be noted that the application of the encoder effectively ensures that the number of turns of the servo motor 721 rotating each time is a fixed value, thereby ensuring that each centrifuge tube rack 74 returns to the initial position after completing the centrifugal processing, and realizing the positioning function of the centrifuge tube rack 74;
the power mechanism 72 further comprises two fastening devices 725; the two fastening devices 725 are respectively arranged below the bottom frame 712 at two sides of the synchronous belt 723, and the positions of the two fastening devices 725 are adjustable, so that the tightness of the synchronous belt 723 can be adjusted, and the transmission accuracy is effectively ensured;
the bottom of each centrifuge tube shelf 74 is provided with a gravity pressing block 741, and when the centrifugal work is finished, each centrifuge tube shelf 74 is reset under the gravity action of the gravity pressing block 741;
the top cover 711 is provided with a cover plate accommodating groove, and a cover plate 7111 is placed in the cover plate accommodating groove; handles 7112 are arranged on two sides of the cover plate 7111 respectively and used for grabbing the cover plate 7111; an observation window 7113 is also arranged between the two handles 7112 of the cover plate 7111, so that an operator can observe the working state in the centrifugal cavity conveniently;
preferably, the number of the centrifuge tube racks 74 is four, and correspondingly, the number of the mounting bins 7321 is also four;
the centrifugal mechanism 7 also comprises a waste material barrel and a waste liquid groove; waste bucket and waste liquid groove in set gradually on work platform after to in the past between casing 71 and the dyeing mechanism 8, the waste bucket is used for retrieving the centrifuging tube, the waste liquid groove is used for retrieving centrifugal waste liquid.
The staining mechanism 8 comprises a plurality of slide staining assemblies 81 and a bracket; the bracket is arranged on the working platform; a plurality of slide staining assemblies 81 are arranged on the bracket, so that the slide staining assemblies can be conveniently taken and placed;
the dyeing mechanism 8 further comprises a recovery tank 82 for recovering waste liquid; the recovery groove 82 is arranged on the working platform at the right side of the bracket;
the dyeing mechanism 8 further comprises a recycling bin 83 for recycling waste materials; the recycling bin 83 is arranged on the working platform at the rear side of the bracket;
each of the slide staining assemblies 81 includes:
the dyeing bottle 811 is hollow, the bottom of the dyeing bottle is provided with an annular bulge 8111 and a rubber ring 8112, and two opposite sides of the annular bulge 8111 are respectively extended with a lug 8113;
the carrier plate 812 is provided with grooves 8121 which are arranged in an array manner, the grooves 8121 are used for accommodating slides 8122, and two inner sides of each groove 8121 are provided with buckling positions 8123 which are used for buckling a bump 8113 of an annular bulge 8111 at the bottom of the dyeing bottle 811;
wherein, two sides of the carrier 812 are provided with a handle 8124 for transferring the carrier 812;
preferably, the number of the slide staining assemblies 81 is two.
The X-axis sliding mechanism 2 comprises an X-axis slide rail 21, a first motor 22 arranged at the end part of the X-axis slide rail 21 and a chain 23 arranged at the output end of the first motor 22; the chain 23 is arranged on the track of the X-axis slide rail 21 and can slide back and forth along the track of the X-axis slide rail 21; the pipetting mechanism 4 is provided on a chain 23 and can move back and forth on the X-axis slide rail 21 along the chain 23.
The Y-axis sliding mechanism 3 comprises a Y-axis slide rail 31, a slide block 32 connected with the Y-axis slide rail 31 in a sliding manner, and a belt type conveying mechanism for providing power for the slide block 32;
the belt type conveying mechanism comprises a second motor 33, a driving wheel 34 connected with the output end of the second motor 33, a driven wheel 35 matched with the driving wheel 34, and belts arranged on the driving wheel 34 and the driven wheel 35; the slider 32 is disposed on a belt 36.
The pipetting mechanism 4 comprises a first pipetting assembly 41, a first pipetting groove 42 matched with the first pipetting assembly 41, a second pipetting assembly 43, a second pipetting groove 44 matched with the second pipetting assembly 43, a specimen groove 45 and a connecting plate 46; the connecting plate 46 is arranged on the chain 23 and can move along the chain 23 in a manner of sliding back and forth on the X-axis slide rail 21; the first pipetting assembly 41 and the second pipetting assembly 43 are sequentially arranged on the connecting plate 46 from front to back and are respectively used for pipetting;
the first pipetting assembly 41 comprises a third motor 411 and a first pipetting gun 412 connected with the output end of the third motor 411; the first liquid-transferring gun 412 is also communicated with the feeding mechanism 6 through a material pipe; the first pipetting groove 42 is arranged on the working platform at the front side of the centrifugal mechanism 7, and a plurality of first pipettes matched with the first pipetting gun 412 are placed in the first pipetting groove 42, and the first pipetting gun 412 is driven to move up and down by the third motor 411, so that the first pipettes can be sleeved on the head of the first pipetting gun 412;
the second pipetting assembly 43 comprises a fourth motor 431 and a second pipetting gun 432 connected with the output end of the fourth motor 431; the second liquid-transferring gun 432 is also communicated with the feeding mechanism 6 through a material pipe; the second pipetting groove 44 is arranged on the working platform at the front side of the waste barrel, a plurality of second pipettes matched with the second pipetting gun 432 are placed in the second pipetting groove 44, the second pipetting gun 432 is driven to move up and down by the fourth motor 431, and then the second pipettes can be sleeved at the head of the second pipetting gun 432;
the sample liquid tank 45 is arranged on the working platform between the second liquid transferring tank 44 and the dyeing mechanism 8, and a plurality of sample liquid tubes are placed in the sample liquid tank 45.
The injection mechanism 5 comprises a mounting frame 51, a fifth motor 54 arranged on the mounting frame 51, a support plate 52 connected with the output end of the fifth motor 54, and a plurality of injection assemblies 53 matched with the grooves 8121 arranged in an array on the carrier plate 812; the mounting frame 51 is arranged on the right side of the X-axis slide rail 21, each injection assembly 53 is arranged on the support plate 52 at a position corresponding to one row of grooves 8121 on the carrier plate 812, the support plate 52 is driven to move up and down by the fifth motor 54, and then the support plate 52 drives the injection assemblies 53 arranged on the support plate 52 to move up and down;
each of the injection assemblies 53 includes four sets of dyeing needles and one set of waste liquid needles, and the length of the waste liquid needles is greater than the length of the four sets of dyeing needles; each group of dyeing needles is respectively communicated with the feeding mechanism 6 through a material pipe, and then the action of injecting liquid is completed through the feeding mechanism 6; the waste liquid needle is used for sucking out waste liquid.
The feeding mechanism 6 comprises a plurality of pressure pumps 61 matched with the first pipetting gun 412, the second pipetting gun 432 and a plurality of injection assemblies 53; each pressure pump 61 is externally connected with a liquid storage device, the first liquid-transferring gun 412 is communicated with one of the pressure pumps 61 through a material pipe, and the second liquid-transferring gun 432 is communicated with one of the pressure pumps 61 through a material pipe; and the dyeing needle of each injection assembly 53 is correspondingly communicated with one pressure pump 61 through a material pipe, the operation of injecting liquid by the dyeing needle is completed through the action of the pressure pump 61, and the liquid in the material pipe is recovered into the liquid storage device through the action of the pressure pump 61, so that the pipe arrangement operation is completed.
The working process and principle of the invention are as follows: first, the centrifuge tubes are manually placed on a centrifuge tube rack 74; next, after selecting the number of specimens, the staining mode and the slide making mode on the operation interface of the control device 9, pressing a running key to run the equipment; the first pipetting assembly 41 is moved above all the centrifuge tubes one by one through the actions of the X-axis sliding mechanism 2 and the Y-axis sliding mechanism 3, and the first pipetting gun 412 is operated through the pressure pump 61 communicated with the first pipetting gun 412 to inject quantitative liquid into each centrifuge tube one by one; next, by the action of the X-axis slide mechanism 2 and the Y-axis slide mechanism 3, the first pipetting assembly 41 is moved above the first pipetting groove 42, and drives the first pipetting gun 412 to move downwards through the third motor 411, thereby completing the combined action of the first pipetting gun 412 and the first pipette, then, the first pipette is moved to the upper part of the sample liquid tube by the actions of the X-axis sliding mechanism 2 and the Y-axis sliding mechanism 3, the first pipette gun 412 is driven by the third motor 411 to move downwards, so that the first pipette is extended into the first pipette to suck the sample liquid, and drives the first pipette to move above the centrifuge tube through the actions of the X-axis sliding mechanism 2 and the Y-axis sliding mechanism 3, further completing the action of transferring the sample liquid to the centrifuge tubes, and executing the action for multiple times until the sample liquid is injected into all the centrifuge tubes; next, the centrifugal operation is completed by the action of the centrifugal mechanism 7; after the centrifugation is finished, the first transfer pipette extracts and discards the upper layer liquid in the centrifugal tube to a waste liquid tank; next, the second pipetting assembly 43 is moved above the second pipetting groove 44 by the actions of the X-axis sliding mechanism 2 and the Y-axis sliding mechanism 3, and the second pipetting gun 432 is driven by the fourth motor 431 to move downwards, so that the combined action of the second pipetting gun 432 and the second pipette is completed, then the second pipetting assembly 43 is moved above all the centrifuge tubes by the actions of the X-axis sliding mechanism 2 and the Y-axis sliding mechanism 3, and the second pipetting gun 432 is operated by the pressure pump 61 communicated with the second pipetting gun 432, so that the second pipetting gun 432 injects a fixed amount of liquid into each centrifuge tube, after the liquids in the centrifuge tubes are mixed uniformly, the second pipette quantitatively transfers the liquid into the dyeing bottle for sedimentation and production 811 by the actions of the X-axis sliding mechanism 2, the Y-axis sliding mechanism 3, the fourth motor 431 and the second pipetting gun 432; next, the injection mechanism 5 is moved above the dyeing bottle 811 by the action of the Y-axis sliding mechanism 3, and the operation of dyeing according to the flow is completed by the action of the feeding mechanism 6; after the flaking and dyeing are finished, carrying out the flaking operation; next, a rack pipe arranging key is pressed on the operation interface of the control device 9 to arrange the rack pipe, and then the machine is turned off. And repeating the actions to realize batch automatic film production.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A tablet-making and dyeing machine, comprising: ㄈ type frame, X-axis sliding mechanism, Y-axis sliding mechanism, liquid-transferring mechanism, injection mechanism, feeding mechanism, centrifugal mechanism, dyeing mechanism and control device which are matched with the liquid-transferring mechanism and the injection mechanism; the Y-axis sliding mechanism is arranged at the upper part of the ㄈ -type framework, and the X-axis sliding mechanism is connected with the Y-axis sliding mechanism in a sliding manner and can slide left and right along the Y-axis direction of the Y-axis sliding mechanism; the pipetting mechanism is arranged on the left side of the X-axis sliding mechanism, is connected with the X-axis sliding mechanism in a sliding manner and can slide back and forth along the X-axis direction of the X-axis sliding mechanism; the injection mechanism is arranged on the right side of the X-axis sliding mechanism; the feeding mechanism is arranged on the vertical part of the model ㄈ rack and is communicated with the pipetting mechanism and the injection mechanism; the bottom of the ㄈ -type frame is provided with a working platform, and the centrifugal mechanism, the dyeing mechanism and the control device are sequentially arranged on the working platform from left to right; the control device is respectively electrically connected with the X-axis sliding mechanism, the Y-axis sliding mechanism, the liquid transferring mechanism, the injection mechanism, the feeding mechanism and the centrifugal mechanism and is used for controlling the operation of equipment.
2. The slice-making and dyeing machine of claim 1, wherein said centrifuge mechanism comprises a housing, a power mechanism, a rotation mechanism, and a plurality of centrifuge tube racks; the shell comprises a top cover and a bottom frame which can be separated, the top cover is arranged above the bottom frame, and a centrifugal cavity is arranged in the bottom frame; the rotating mechanism is arranged below the working platform, and the top of the rotating mechanism sequentially penetrates out of the working platform and the bottom frame upwards and is placed in the centrifugal cavity; the plurality of centrifuge tube racks are rotatably arranged at the top of the rotating mechanism, each centrifuge tube rack is uniformly provided with a plurality of tube holes, and a centrifuge tube is arranged in each tube hole; the power mechanism is arranged below the working platform at one side of the rotating mechanism and is connected with the rotating mechanism;
the centrifugal mechanism also comprises a waste material barrel and a waste liquid groove; waste bucket and waste liquid groove in set gradually on work platform after to in the past between casing and the dyeing mechanism, the waste bucket is used for retrieving the centrifuging tube, the waste liquid groove is used for retrieving centrifugal waste liquid.
3. The slice-dyeing machine of claim 2, wherein said rotating mechanism is comprised of a support base, a rotating bracket and a pressure plate; the supporting seat can be rotatably arranged below the working platform around the axis of the supporting seat, the bottom of the supporting seat is connected with the power mechanism, and the top of the supporting seat sequentially penetrates out of the working platform and the bottom frame upwards and is arranged in the centrifugal cavity; the rotating bracket is fixedly arranged at the top of the supporting seat, the rotating bracket is uniformly provided with a plurality of mounting bins matched with the number of the centrifuge tube racks, and the centrifuge tube racks can be rotatably arranged in each mounting bin; the clamp plate in centrifuge tube rack top install in on the runing rest, just the clamp plate corresponds every the position in installation storehouse is equipped with protruding finger, every centrifuge tube rack in the installation storehouse corresponds the position of protruding finger is equipped with the draw-in groove.
4. The slice-making and dyeing machine of claim 3, wherein said power mechanism comprises a servo motor with an encoder, a transmission gear, a synchronous belt and a rotary gear; the rotating gear is fixedly arranged at the bottom of the supporting seat; the servo motor is arranged on one side of the rotating gear; the transmission gear is fixedly arranged on an output shaft of the servo motor; the synchronous belt is arranged on the transmission gear and the rotating gear;
the power mechanism also comprises two fastening devices; the two tightening devices are respectively arranged below the bottom frame at two sides of the synchronous belt and used for adjusting the tightness of the synchronous belt;
the bottom of each centrifuge tube rack is provided with a gravity pressing block;
the top cover is provided with a cover plate accommodating groove, and a cover plate is arranged in the cover plate accommodating groove; handles are arranged on two sides of the cover plate respectively and used for grabbing the cover plate; the cover plate is also provided with an observation window between the two handles.
5. The slide staining machine of claim 1 wherein the staining mechanism comprises a number of slide staining assemblies and a carriage; the bracket is arranged on the working platform; a plurality of slide staining assemblies disposed on the carrier;
the dyeing mechanism further comprises a recovery tank for recovering waste liquid; the recovery tank is arranged on the working platform at the right side of the bracket;
the dyeing mechanism further comprises a recovery barrel for recovering waste materials; the recycling bin is arranged on the working platform at the rear side of the bracket;
each of the slide staining assemblies includes:
the dyeing bottle is hollow, the bottom of the dyeing bottle is provided with an annular bulge and a rubber ring, and two opposite sides of the annular bulge are respectively extended with a lug;
the glass slide dyeing device comprises a carrier plate, a plurality of dyeing bottles and a plurality of dyeing pieces, wherein the carrier plate is provided with grooves which are arranged in an array manner and are used for accommodating glass slides, and two inner sides of each groove are provided with buckling positions for buckling annular raised bumps at the bottom of each dyeing bottle;
wherein, the two sides of the carrier plate are provided with handles for transferring the carrier plate.
6. The slice-dyeing machine of claim 1, wherein said X-axis sliding mechanism comprises an X-axis slide rail, a first motor disposed at an end of the X-axis slide rail, and a chain disposed at an output end of the first motor; the chain is arranged on the track of the X-axis slide rail and can slide back and forth along the track of the X-axis slide rail; the liquid-transfering mechanism is arranged on the chain and can slide back and forth on the X-axis slide rail along the chain to move.
7. The slice-making and dyeing machine of claim 1, wherein said Y-axis slide mechanism comprises a Y-axis slide rail, a slide block slidably connected to the Y-axis slide rail, and a belt-type conveying mechanism for powering the slide block;
the belt type conveying mechanism comprises a second motor, a driving wheel connected with the output end of the second motor, a driven wheel matched with the driving wheel, and belts arranged on the driving wheel and the driven wheel; the slider is arranged on the belt.
8. The slide dyeing machine according to claim 6, wherein the pipetting mechanism comprises a first pipetting assembly, a first pipetting tank cooperating with the first pipetting assembly, a second pipetting tank cooperating with the second pipetting assembly, a specimen tank, and a connection plate; the connecting plate is arranged on the chain and can slide back and forth on the X-axis slide rail along the chain to move; the first pipetting assembly and the second pipetting assembly are sequentially arranged on the connecting plate from front to back and are respectively used for pipetting;
the first pipetting assembly comprises a third motor and a first pipetting gun connected with the output end of the third motor; the first liquid-transferring gun is also communicated with the feeding mechanism through a material pipe; the first liquid transferring groove is arranged on the working platform at the front side of the centrifugal mechanism, and a plurality of first liquid transferring pipes matched with the first liquid transferring gun are arranged in the first liquid transferring groove;
the second pipetting assembly comprises a fourth motor and a second pipetting gun connected with the output end of the fourth motor; the second liquid-transferring gun is also communicated with the feeding mechanism through a material pipe; the second liquid transferring groove is arranged on the working platform at the front side of the waste barrel, and a plurality of second liquid transferring pipes matched with the second liquid transferring gun are arranged in the second liquid transferring groove;
the specimen liquid tank is arranged on the working platform between the second liquid transferring tank and the dyeing mechanism, and a plurality of specimen liquid tubes are placed in the specimen liquid tank.
9. The slice-making and dyeing machine of claim 8, wherein said injection mechanism comprises a mounting frame, a fifth motor mounted on said mounting frame, a support plate connected to an output of said fifth motor, and a plurality of injection modules engaged with said grooves arranged in an array on said support plate; the mounting frame is arranged on the right side of the X-axis slide rail, and each injection assembly is arranged on the supporting plate at a position corresponding to a row of grooves on the carrier plate respectively;
each injection assembly comprises a plurality of groups of dyeing needles and a group of waste liquid needles, and the length of each waste liquid needle is greater than that of each group of dyeing needles; each group of dyeing needles is respectively communicated with the feeding mechanism through a material pipe; the waste liquid needle is used for sucking out waste liquid.
10. The slice-dyeing machine of claim 9, wherein said feed mechanism includes a plurality of pressure pumps cooperating with a first pipetting gun, a second pipetting gun, and a plurality of injection assemblies; each pressure pump is externally connected with a liquid storage device, the first liquid-transferring gun is communicated with one of the pressure pumps through a material pipe, the second liquid-transferring gun is communicated with one of the pressure pumps through a material pipe, and the dyeing needle of each injection assembly is correspondingly communicated with one of the pressure pumps through the material pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010280908.8A CN111366441A (en) | 2020-04-10 | 2020-04-10 | Tablet-making dyeing machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010280908.8A CN111366441A (en) | 2020-04-10 | 2020-04-10 | Tablet-making dyeing machine |
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| Publication Number | Publication Date |
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| CN111366441A true CN111366441A (en) | 2020-07-03 |
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ID=71209336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010280908.8A Pending CN111366441A (en) | 2020-04-10 | 2020-04-10 | Tablet-making dyeing machine |
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| CN (1) | CN111366441A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112179738A (en) * | 2020-09-30 | 2021-01-05 | 易普森生物科技(深圳)有限公司 | Novel cell pelleter |
| CN115950714A (en) * | 2022-12-27 | 2023-04-11 | 武汉中纪生物科技有限公司 | Move liquid dyeing and move back first device |
-
2020
- 2020-04-10 CN CN202010280908.8A patent/CN111366441A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112179738A (en) * | 2020-09-30 | 2021-01-05 | 易普森生物科技(深圳)有限公司 | Novel cell pelleter |
| CN112179738B (en) * | 2020-09-30 | 2021-07-13 | 易普森生物科技(深圳)有限公司 | Novel cell pelleter |
| CN115950714A (en) * | 2022-12-27 | 2023-04-11 | 武汉中纪生物科技有限公司 | Move liquid dyeing and move back first device |
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