CN111358871A - A Chinese medicinal composition containing cannabidiol CBD extract for treating intestinal tract diseases of livestock and fowl - Google Patents
A Chinese medicinal composition containing cannabidiol CBD extract for treating intestinal tract diseases of livestock and fowl Download PDFInfo
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- CN111358871A CN111358871A CN201910799317.9A CN201910799317A CN111358871A CN 111358871 A CN111358871 A CN 111358871A CN 201910799317 A CN201910799317 A CN 201910799317A CN 111358871 A CN111358871 A CN 111358871A
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a method for treating intestinal diseases of livestock by using Cannabidiol (CBD) extract, belonging to the technical field of research and development and production of Cannabidiol (CBD) plant extract Chinese herbal medicines and the field of veterinary medicines, and comprising the steps of enabling CBD to promote each raw material medicine to mutually exert synergistic action and exert maximum drug effect, playing the roles of clearing heat and drying dampness, diminishing inflammation, promoting urination, detoxifying and resolving masses and strengthening spleen and eliminating dampness, having good inhibition and killing effects on pathogenic bacteria such as escherichia coli, dysentery bacillus and the like, helping to discharge vivotoxin, improving the disease resistance of livestock and effectively preventing enteritis and diarrhea, having the advantages of pure Chinese herbal medicines of no antibiotic toxic or side effect, no drug resistance and the like, solving the problem that the enteritis and diarrhea treatment of livestock at the present stage mainly depend on chemical medicines, and the drug resistance is easily generated by using antibiotics for a long time and residual in vivo and bacteria, the defect of poor treatment effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions and traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for preventing and treating enteritis, bacillary dysentery, dysentery and intractable diarrhea and a preparation method thereof.
Background
Enteritis diarrhea is a common multiple gastrointestinal infectious disease caused by escherichia coli, salmonella and some viruses. The disease has strong infectivity and high incidence rate, and is easy to cause epidemic. In the modern breeding industry, enteritis and diarrhea are the most common diseases, and especially newborn young livestock and poultry are easy to frequently occur, and have the characteristics of high morbidity and high mortality. Because the livestock and poultry at the stage have the characteristics of poor resistance, incomplete development of digestive systems and the like, the livestock and poultry are very easy to cause infection of bacteria, viruses, parasites and the like to cause diarrhea, and stress reactions such as weather mutation, turning, transportation and the like and dyspepsia are also causes of the diarrhea. If the patient is not treated reasonably in time, the condition of the patient can be further changed into chronic diarrhea, the growth speed of the young livestock and poultry is affected, and the serious condition can cause dehydration and even death due to vomiting, fasting and electrolyte disturbance. At present, the treatment of enteritis and diarrhea mainly takes chemical drugs as main drugs, but bacteria are easy to generate drug resistance after long-term use of antibiotics, and once the drug-resistant bacteria are generated, the antibiotic treatment cannot achieve the effect.
Therefore, a drug which has no drug resistance and residue and can better prevent and treat enteritis diarrhea of livestock and poultry is urgently needed to be provided, so that economic loss caused by the disease is reduced, and the economic benefit of cultivation is indirectly increased.
Cannabidiol (CBD) is a non-toxic high value-added phenolic substance extracted from cannabis sativa leaves and used in medicines, cosmetics and health foods. Developed countries such as Israel, the United states, the United kingdom and the like have used the raw materials and developed various specific medicines and cosmetics. CBD is a non-addictive component in marijuana, can block the effect of THC on human nervous system, has pharmacological activities such as antispasmodic and anxiolytic activity, and is known to be used as an active ingredient of a medicament for treating diseases such as epilepsy, diabetes, neonatal hypoxic-ischemic encephalopathy, and the like. However, in the prior art, a gap exists in the treatment of gastrointestinal diseases of livestock and poultry through cannabidiol CBD, and therefore, an application of an extract containing cannabidiol CBD in the treatment of gastrointestinal diseases of livestock and poultry is provided.
Disclosure of Invention
Aiming at the technical problems in the prior art, the invention provides a traditional Chinese medicine composition containing a CBD extract of cannabidiol for preventing and treating gastrointestinal diseases of livestock and poultry.
On one hand, the invention provides a cannabidiol CBD extract-containing traditional Chinese medicine composition for preventing and treating gastrointestinal diseases of livestock, which comprises the following components: cannabidiol CBD, rhizoma acori graminei, cortex phellodendri, radix scutellariae and rhizoma atractylodis macrocephalae.
Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 0.01-1g of cannabidiol CDB, 3-9g of rhizoma acori graminei, 0.5-30 g of cortex phellodendri, 3-10g of scutellaria baicalensis and 3-9g of bighead atractylodes rhizome.
Further, the most preferable components are 0.2g of cannabidiol CDB, 5g of rhizoma acori graminei, 5g of cortex phellodendri, 5g of radix scutellariae and 3g of rhizoma atractylodis macrocephalae.
The pharmaceutical composition provided by the invention is an oral preparation or an injection preparation.
Further, the oral preparation comprises pills, capsules, tablets, powder, granules or oral liquid.
Furthermore, the invention also provides a preparation method of the medicine containing cannabidiol CBD extract for preventing and treating gastrointestinal diseases of livestock, which comprises the following specific steps: the traditional Chinese medicine composition is mixed and crushed, and is extracted by water or other solvents, and the extract is mixed with a pharmaceutically acceptable carrier to prepare the traditional Chinese medicine composition. The other solvent can be ethanol solution, diethyl ether, etc.
The composition of the medicine is added with various conventional auxiliary materials required by preparing different dosage forms, such as a disintegrating agent, a lubricating agent, an adhesive, a preservative and the like, and is prepared into any one common medicine preparation by a conventional Chinese medicine preparation method (such as crushing, tabletting, decoction extraction, solvent extraction and the like). Such as pill, capsule, tablet, powder, granule, oral liquid or injection.
The Chinese herbal medicine raw materials used in the invention all meet the national medical standards.
The application and dosage are as follows: the dosage of the invention depends on factors such as specific dosage form, livestock and poultry type, livestock and poultry weight, health condition and the like. As a guide for usage and dosage: the oral administration is carried out twice a day, the amount of the poultry per time is 0.3-0.5 g of the crude drug, the intramuscular injection is carried out twice a day, and the amount of the poultry per 1kg of body weight is 1.5 g of the crude drug; the dosage of the pig and the sheep is equal to 30-60 g of crude drug each time, intramuscular injection is carried out twice a day, and 1kg of body weight of each time is equal to 1g of the crude drug; the dosage of large animals such as cattle, horses and the like is equivalent to 250-500 g of crude drugs each time; intramuscular injection is performed twice a day, and each time of 1kg of body weight of the intramuscular injection is equivalent to 1g of the crude drug.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine composition provided by the invention has the effects of clearing heat, drying dampness, diminishing inflammation, promoting urination, detoxifying, resolving hard mass, invigorating spleen and eliminating dampness by virtue of mutual synergy of all the raw material medicines, has the effects of inhibiting and killing pathogens such as escherichia coli and shigella dysenteriae, helping to discharge vivotoxin, improving the disease resistance of livestock and poultry (such as piglets, ruminants and the like), effectively preventing and treating enteritis and diarrhea and promoting recovery of livestock and poultry (such as piglets, poultry and the like). The invention is a pure Chinese medicinal preparation, and has the advantages of small toxic and side effects, difficult generation of drug resistance and the like. Solves the problem that the antibacterial drug is not ideal for treating piglet diarrhea, poultry dysentery and the like.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments that can be derived by one of ordinary skill in the art from the embodiments given herein are intended to be within the scope of the present invention. Unless otherwise defined, all terms of art used hereinafter have the same meaning as commonly understood by one of ordinary skill in the art. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention.
Example 1: preparation of Chinese medicinal powder
Weighing the traditional Chinese medicinal materials according to the following formula proportion:
the components and the dosage (g): 0.5 of cannabidiol CDB, 280 of rhizoma acori graminei, 280 of cortex phellodendri, 270 of radix scutellariae and 169.5 of rhizoma atractylodis macrocephalae, and the total amount is 1000.
The process comprises the following steps:
1. the raw materials of the traditional Chinese medicines all accord with the national medicine standard;
2. pulverizing cannabidiol CBD, rhizoma acori graminei, cortex phellodendri, radix scutellariae and rhizoma atractylodis macrocephalae respectively for later use;
3. mixing the above Chinese medicinal materials at a certain proportion;
4. subpackaging, sealing and packaging.
Example 2: preparation of soluble powder of traditional Chinese medicine
Weighing the extracts of the Chinese medicinal materials according to the following formula proportion:
the components and the dosage (g): 0.5 of cannabidiol CDB, 280 of rhizoma acori graminei, 280 of cortex phellodendri, 270 of radix scutellariae and 169.5 of rhizoma atractylodis macrocephalae, and the total amount is 1000.
The process comprises the following steps:
1. the raw materials of the traditional Chinese medicines all accord with the national medicine standard;
2. extracting cannabidiol CBD, rhizoma acori graminei, cortex phellodendri, radix scutellariae and rhizoma atractylodis macrocephalae respectively according to a traditional Chinese medicine extraction method to obtain extracts of various herbs for later use;
3. mixing the above extracts at a certain proportion;
4. subpackaging, sealing and packaging.
Example 3: preparation of Chinese medicine injection
Weighing the traditional Chinese medicinal materials and the auxiliary materials according to the following formula proportion:
the components and the dosage (g): 0.2 parts of cannabidiol CDB, 255 parts of grassleaf sweelflag rhizome, 255 parts of amur corktree bark, 255 parts of baical skullcap root, 150 parts of largehead atractylodes rhizome, 80 parts of Tween, 4.8 parts of benzyl alcohol and 1000ml of water.
The process comprises the following steps:
1. the traditional Chinese medicine raw materials all meet the national medicine standard;
2. mixing cannabidiol CBD, rhizoma acori graminei, cortex phellodendri, scutellaria baicalensis and bighead atractylodes rhizome according to the proportion, adding water or other solvents, and extracting according to a traditional Chinese medicine extraction method to obtain an extract for later use;
3. adding appropriate adjuvant and injectable water into the above extract to make into injection;
4. then the packaging, sterilization, lamp inspection and bag printing are carried out.
Example 4: preparation of Chinese medicinal tablet
Weighing the traditional Chinese medicinal materials and the auxiliary materials according to the following formula proportion:
the components and the dosage (g): 0.5 of cannabidiol CDB, 280 of grassleaf sweelflag rhizome, 280 of amur corktree bark, 270 of baical skullcap root, 169.5 of largehead atractylodes rhizome,
making into tablet with appropriate amount of starch slurry.
The process comprises the following steps:
1. the traditional Chinese medicine raw materials all meet the national medicine standard;
2. mixing cannabidiol CBD, rhizoma acori graminei, cortex phellodendri, radix scutellariae and rhizoma atractylodis macrocephalae in proportion, crushing and sieving with a 80-mesh sieve for later use;
3. adding appropriate adjuvants into the above mixture, bonding, and tabletting into 3 g/tablet with a tabletting machine;
4. filling, packaging, sealing and packaging.
Example 5: preparation of Chinese medicinal granule
Weighing the traditional Chinese medicinal materials and the auxiliary materials according to the following formula proportion:
the components and the dosage (g): cannabidiol CDB 0.2, rhizoma acori graminei 255, cortex phellodendri 255, radix scutellariae 255, rhizoma atractylodis macrocephalae 150, tween 80 and a proper amount of dextrin, and the granules are prepared into 1000 g.
The process comprises the following steps:
1. the traditional Chinese medicine raw materials all meet the national medicine standard;
2. mixing cannabidiol CBD, rhizoma acori graminei, cortex phellodendri, radix scutellariae and rhizoma atractylodis macrocephalae in proportion, adding water or other solvents, and extracting by a traditional Chinese medicine extraction method to obtain an extract for later use;
3. adding appropriate amount of dextrin into the above extract for adsorption, drying, granulating into water soluble granule with granulator, and drying;
4. packaging with plastic bag, sealing, and packaging.
Experimental example 1 clinical efficacy test for treating dysentery of sows after passing milk
The self-description of a certain pig farm farmer in Yu county: the number of sows in the field is 50, and all sows are positive through antibody detection of swine fever, pseudorabies, blue ears, circular rings and the like. About 95% of newly born piglets are stained with yellow or grey-white thin feces and feces, and generally continue for 3-5 days, 60% of piglets die due to emaciation and dehydration, and the piglets drinking colostrum are more serious. The treatment effect is poor by using antibiotics (such as amoxicillin, doxycycline hydrochloride, tilmicosin, florfenicol and the like). About 20 sows delivered in 2016, 4 months, so consult pens to call. The powder of the invention example 1 is recommended to be used in a pig farm 5 days before parturition, 50g is given to each sow every time, twice a day and 3 days are given continuously; the results of soaking the sows in the powder of the invention in the embodiment 1 in a proper amount of boiled water for 30 minutes at the day of delivery, taking the soaking solution to drink the sows once, and then continuing to use the powder for three days after delivery show that only 1.5 percent of the piglets of the sows treated by the powder of the invention have diarrhea and the survival rate reaches 98.5 percent, but the diarrhea is controlled but 8 piglets die compared with 20 piglets of 2 sows which have not used the powder of the invention in the embodiment 1 after delivery.
Test example 2 clinical efficacy test for poultry
In 2018, in 5 months, 5000 laying hens in a certain laying hen farm in Huaiyang have enteritis and diarrhea, yellow and white and grey-white thin feces are pulled out, the feces are stuck to the anus, the appetite is reduced, the spirit is withered, and the drinking desire is increased greatly. According to clinical symptoms, case analysis and laboratory detection, the occurrence of colibacillosis of laying hens in the laying hen farm is confirmed, and antibiotics are adopted for prevention and treatment all the time for several years, and then the treatment with the antibiotics is completely failed. Immediately mixing the traditional Chinese medicine powder prepared in the powder example 1 with the laying hens at a dose of 2g per kg of body weight by using the powder for livestock, controlling death in 3 days, completely recovering the appetite and spirit of the chicken flocks in 4 days, completely recovering the chickens in 5 days, and ensuring normal egg yield in 7 days.
It should be understood that the above-described embodiments of the present invention are illustrative for clarity and are not intended to limit the scope of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (7)
1. A traditional Chinese medicine composition containing cannabidiol CBD extract for treating intestinal tract diseases of livestock is characterized by comprising the following components: cannabidiol CDB, rhizoma acori graminei, cortex phellodendri, radix scutellariae and rhizoma atractylodis macrocephalae;
the traditional Chinese medicine composition for treating intestinal diseases of livestock and poultry according to claim 1, which is characterized in that the traditional Chinese medicine composition is: 0.01-1g of cannabidiol CDB, 3-9g of rhizoma acori graminei, 0.5-30 g of cortex phellodendri, 3-10g of scutellaria baicalensis and 3-9g of bighead atractylodes rhizome.
2. The Chinese medicinal composition according to claim 2, wherein the composition comprises cannabidiol CDB 0.2g, rhizoma Acori Tatarinowii 5g, cortex Phellodendri 5g, radix Scutellariae 5g, and rhizoma Atractylodis Macrocephalae 3 g.
3. The traditional Chinese medicine composition for treating intestinal diseases of livestock and poultry according to claim 1, wherein the dosage form is oral preparation or injection preparation.
4. The pharmaceutical composition of claim 4, wherein the oral formulation comprises a pill, a capsule, a tablet, a powder, a granule or an oral liquid.
5. A Chinese medicinal composition containing CBD extract of cannabidiol for treating intestinal tract diseases of livestock and poultry is prepared by mixing the Chinese medicinal composition of claim 1, pulverizing, extracting with water or other solvent, and mixing the extract with pharmaceutically acceptable carrier.
6. Furthermore, the invention also comprises a preparation method of the traditional Chinese medicine composition as claimed in claim 1, which comprises the following specific steps: the traditional Chinese medicine composition is mixed and crushed, and is extracted by water or other solvents, and the extract is mixed with a pharmaceutically acceptable carrier to prepare the traditional Chinese medicine composition.
7. The other solvent can be ethanol solution, diethyl ether, etc.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910799317.9A CN111358871A (en) | 2019-08-28 | 2019-08-28 | A Chinese medicinal composition containing cannabidiol CBD extract for treating intestinal tract diseases of livestock and fowl |
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| CN201910799317.9A CN111358871A (en) | 2019-08-28 | 2019-08-28 | A Chinese medicinal composition containing cannabidiol CBD extract for treating intestinal tract diseases of livestock and fowl |
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Application publication date: 20200703 |