CN111356431A - 包含烷基聚糖苷作为反相剂自可逆反相胶乳,其作为增稠剂的用途,以及包含其的化妆品组合物 - Google Patents
包含烷基聚糖苷作为反相剂自可逆反相胶乳,其作为增稠剂的用途,以及包含其的化妆品组合物 Download PDFInfo
- Publication number
- CN111356431A CN111356431A CN201880074172.XA CN201880074172A CN111356431A CN 111356431 A CN111356431 A CN 111356431A CN 201880074172 A CN201880074172 A CN 201880074172A CN 111356431 A CN111356431 A CN 111356431A
- Authority
- CN
- China
- Prior art keywords
- equal
- mass
- less
- composition
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 183
- 239000002537 cosmetic Substances 0.000 title claims abstract description 20
- 239000002562 thickening agent Substances 0.000 title claims abstract description 14
- 229920000126 latex Polymers 0.000 title abstract description 36
- 239000004816 latex Substances 0.000 title abstract description 28
- 125000000217 alkyl group Chemical group 0.000 title abstract description 13
- 230000000699 topical effect Effects 0.000 claims abstract description 10
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 239000003381 stabilizer Substances 0.000 claims abstract description 5
- -1 (1-oxo-2-propenyl) amino Chemical group 0.000 claims description 80
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 58
- 239000003921 oil Substances 0.000 claims description 56
- 239000007762 w/o emulsion Substances 0.000 claims description 44
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 43
- 239000000178 monomer Substances 0.000 claims description 37
- 239000000839 emulsion Substances 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 33
- 235000000346 sugar Nutrition 0.000 claims description 28
- 229920001577 copolymer Polymers 0.000 claims description 19
- 230000001804 emulsifying effect Effects 0.000 claims description 16
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 14
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 13
- 159000000000 sodium salts Chemical class 0.000 claims description 13
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 12
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 11
- 238000006116 polymerization reaction Methods 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 9
- 150000003863 ammonium salts Chemical class 0.000 claims description 9
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 9
- 239000003085 diluting agent Substances 0.000 claims description 8
- VPYJNCGUESNPMV-UHFFFAOYSA-N triallylamine Chemical compound C=CCN(CC=C)CC=C VPYJNCGUESNPMV-UHFFFAOYSA-N 0.000 claims description 8
- 229920006037 cross link polymer Polymers 0.000 claims description 7
- 238000004132 cross linking Methods 0.000 claims description 7
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 6
- 229920001519 homopolymer Polymers 0.000 claims description 5
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 claims description 4
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 claims description 4
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 4
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 3
- 239000012049 topical pharmaceutical composition Substances 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- NJMYQRVWBCSLEU-UHFFFAOYSA-N 4-hydroxy-2-methylidenebutanoic acid Chemical class OCCC(=C)C(O)=O NJMYQRVWBCSLEU-UHFFFAOYSA-N 0.000 claims description 2
- YZCKVEUIGOORGS-IGMARMGPSA-N Protium Chemical compound [1H] YZCKVEUIGOORGS-IGMARMGPSA-N 0.000 claims 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 abstract description 23
- 239000003795 chemical substances by application Substances 0.000 abstract description 22
- 125000004432 carbon atom Chemical group C* 0.000 abstract description 21
- 150000002191 fatty alcohols Chemical class 0.000 abstract description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 34
- 229930195729 fatty acid Natural products 0.000 description 34
- 239000000194 fatty acid Substances 0.000 description 34
- 239000012071 phase Substances 0.000 description 29
- 235000019198 oils Nutrition 0.000 description 25
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 16
- 229920001296 polysiloxane Polymers 0.000 description 16
- 210000003491 skin Anatomy 0.000 description 16
- 239000008346 aqueous phase Substances 0.000 description 15
- 150000004665 fatty acids Chemical class 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- 239000000284 extract Substances 0.000 description 13
- 238000009472 formulation Methods 0.000 description 13
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 13
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical class C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 12
- 238000002156 mixing Methods 0.000 description 12
- 235000002639 sodium chloride Nutrition 0.000 description 12
- 230000008719 thickening Effects 0.000 description 12
- 239000000499 gel Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 238000003756 stirring Methods 0.000 description 11
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 150000002148 esters Chemical class 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- 239000000516 sunscreening agent Substances 0.000 description 10
- 239000001993 wax Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 9
- 229920006395 saturated elastomer Polymers 0.000 description 9
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Chemical compound CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 8
- 239000012429 reaction media Substances 0.000 description 8
- 230000000475 sunscreen effect Effects 0.000 description 8
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 7
- 235000009984 Pterocarpus indicus Nutrition 0.000 description 7
- 244000086363 Pterocarpus indicus Species 0.000 description 7
- 229940071160 cocoate Drugs 0.000 description 7
- 239000006071 cream Substances 0.000 description 7
- 239000000419 plant extract Substances 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 239000003599 detergent Substances 0.000 description 6
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 6
- 230000001747 exhibiting effect Effects 0.000 description 6
- 238000005187 foaming Methods 0.000 description 6
- 229930195733 hydrocarbon Natural products 0.000 description 6
- 150000002430 hydrocarbons Chemical class 0.000 description 6
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 6
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 6
- 229940032094 squalane Drugs 0.000 description 6
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 5
- 239000004215 Carbon black (E152) Substances 0.000 description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical group O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 5
- CAHKINHBCWCHCF-UHFFFAOYSA-N N-acetyltyrosine Chemical compound CC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 CAHKINHBCWCHCF-UHFFFAOYSA-N 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 125000001931 aliphatic group Chemical group 0.000 description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
- 239000004359 castor oil Substances 0.000 description 5
- 235000019438 castor oil Nutrition 0.000 description 5
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 229930182478 glucoside Natural products 0.000 description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
- 210000004209 hair Anatomy 0.000 description 5
- 239000000017 hydrogel Substances 0.000 description 5
- 239000002480 mineral oil Substances 0.000 description 5
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 229960004063 propylene glycol Drugs 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 4
- 229940035437 1,3-propanediol Drugs 0.000 description 4
- QENRKQYUEGJNNZ-UHFFFAOYSA-N 2-methyl-1-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound CC(C)C(S(O)(=O)=O)NC(=O)C=C QENRKQYUEGJNNZ-UHFFFAOYSA-N 0.000 description 4
- 229920002307 Dextran Chemical group 0.000 description 4
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 241000750718 Pterocarpus santalinus Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 235000010443 alginic acid Nutrition 0.000 description 4
- 229920000615 alginic acid Polymers 0.000 description 4
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 4
- 229960004050 aminobenzoic acid Drugs 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Chemical group OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Chemical group OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 4
- GLYJVQDYLFAUFC-UHFFFAOYSA-N butyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCC GLYJVQDYLFAUFC-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003349 gelling agent Substances 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 239000007764 o/w emulsion Substances 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- LQPLDXQVILYOOL-UHFFFAOYSA-I pentasodium;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)CC([O-])=O LQPLDXQVILYOOL-UHFFFAOYSA-I 0.000 description 4
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 4
- 229960001860 salicylate Drugs 0.000 description 4
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 4
- 229940001584 sodium metabisulfite Drugs 0.000 description 4
- 235000010262 sodium metabisulphite Nutrition 0.000 description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 4
- 125000000969 xylosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)CO1)* 0.000 description 4
- JNYAEWCLZODPBN-KVTDHHQDSA-N (2r,3r,4r)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@@H](O)[C@H]1O JNYAEWCLZODPBN-KVTDHHQDSA-N 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
- 244000302544 Luffa aegyptiaca Species 0.000 description 3
- 235000009814 Luffa aegyptiaca Nutrition 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 108010009736 Protein Hydrolysates Proteins 0.000 description 3
- 235000019484 Rapeseed oil Nutrition 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 150000001335 aliphatic alkanes Chemical class 0.000 description 3
- 239000008168 almond oil Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 150000008064 anhydrides Chemical class 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 229940120503 dihydroxyacetone Drugs 0.000 description 3
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 3
- 125000004494 ethyl ester group Chemical group 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- YFHFHLSMISYUAQ-UHFFFAOYSA-N farnesane Chemical compound CCC(C)CCCC(C)CCCC(C)C YFHFHLSMISYUAQ-UHFFFAOYSA-N 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 229940075529 glyceryl stearate Drugs 0.000 description 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 239000003999 initiator Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 229940049964 oleate Drugs 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 229920000223 polyglycerol Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000003531 protein hydrolysate Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 150000003871 sulfonates Chemical class 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- LTSWUFKUZPPYEG-UHFFFAOYSA-N 1-decoxydecane Chemical compound CCCCCCCCCCOCCCCCCCCCC LTSWUFKUZPPYEG-UHFFFAOYSA-N 0.000 description 2
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 2
- LEJBBGNFPAFPKQ-UHFFFAOYSA-N 2-(2-prop-2-enoyloxyethoxy)ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOC(=O)C=C LEJBBGNFPAFPKQ-UHFFFAOYSA-N 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- RJWUMFHQJJBBOD-UHFFFAOYSA-N 2-methylheptadecane Chemical compound CCCCCCCCCCCCCCCC(C)C RJWUMFHQJJBBOD-UHFFFAOYSA-N 0.000 description 2
- LEEDMQGKBNGPDN-UHFFFAOYSA-N 2-methylnonadecane Chemical compound CCCCCCCCCCCCCCCCCC(C)C LEEDMQGKBNGPDN-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 2
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- 244000144725 Amygdalus communis Species 0.000 description 2
- 235000011437 Amygdalus communis Nutrition 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 2
- 240000001980 Cucurbita pepo Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 2
- 229920000926 Galactomannan Polymers 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- FLIACVVOZYBSBS-UHFFFAOYSA-N Methyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC FLIACVVOZYBSBS-UHFFFAOYSA-N 0.000 description 2
- HPEUJPJOZXNMSJ-UHFFFAOYSA-N Methyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC HPEUJPJOZXNMSJ-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- DAKWPKUUDNSNPN-UHFFFAOYSA-N Trimethylolpropane triacrylate Chemical compound C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C DAKWPKUUDNSNPN-UHFFFAOYSA-N 0.000 description 2
- 102000003425 Tyrosinase Human genes 0.000 description 2
- 108060008724 Tyrosinase Proteins 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 2
- 125000000089 arabinosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)CO1)* 0.000 description 2
- 125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- DHAZIUXMHRHVMP-UHFFFAOYSA-N butyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCC DHAZIUXMHRHVMP-UHFFFAOYSA-N 0.000 description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N caprylic acid monoglyceride Natural products CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 230000023402 cell communication Effects 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 description 2
- 229940028820 didecyl ether Drugs 0.000 description 2
- 150000005690 diesters Chemical class 0.000 description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- XIRNKXNNONJFQO-UHFFFAOYSA-N ethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC XIRNKXNNONJFQO-UHFFFAOYSA-N 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- MMKRHZKQPFCLLS-UHFFFAOYSA-N ethyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OCC MMKRHZKQPFCLLS-UHFFFAOYSA-N 0.000 description 2
- MVLVMROFTAUDAG-UHFFFAOYSA-N ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC MVLVMROFTAUDAG-UHFFFAOYSA-N 0.000 description 2
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 2
- 229940093471 ethyl oleate Drugs 0.000 description 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 150000002194 fatty esters Chemical class 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229920000591 gum Polymers 0.000 description 2
- IOVYZELOJXWQKD-UHFFFAOYSA-N hexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCC IOVYZELOJXWQKD-UHFFFAOYSA-N 0.000 description 2
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 239000003752 hydrotrope Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 2
- FNWWOHKUXFTKGN-UHFFFAOYSA-N isoheptadecane Natural products CCCCCCCCCCCCCCC(C)C FNWWOHKUXFTKGN-UHFFFAOYSA-N 0.000 description 2
- 229940060384 isostearyl isostearate Drugs 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- KDQIFKKWPMBNOH-UHFFFAOYSA-N methyl 16-methylheptadecanoate Chemical compound COC(=O)CCCCCCCCCCCCCCC(C)C KDQIFKKWPMBNOH-UHFFFAOYSA-N 0.000 description 2
- UQDUPQYQJKYHQI-UHFFFAOYSA-N methyl laurate Chemical compound CCCCCCCCCCCC(=O)OC UQDUPQYQJKYHQI-UHFFFAOYSA-N 0.000 description 2
- ZAZKJZBWRNNLDS-UHFFFAOYSA-N methyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC ZAZKJZBWRNNLDS-UHFFFAOYSA-N 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 239000004200 microcrystalline wax Substances 0.000 description 2
- 235000019808 microcrystalline wax Nutrition 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- WIBFFTLQMKKBLZ-SEYXRHQNSA-N n-butyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCC WIBFFTLQMKKBLZ-SEYXRHQNSA-N 0.000 description 2
- 239000007908 nanoemulsion Substances 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 2
- 229960000969 phenyl salicylate Drugs 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920000867 polyelectrolyte Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- BEKZXQKGTDVSKX-UHFFFAOYSA-N propyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCC BEKZXQKGTDVSKX-UHFFFAOYSA-N 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 2
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 2
- 229950006451 sorbitan laurate Drugs 0.000 description 2
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- CAYKLJBSARHIDI-UHFFFAOYSA-K trichloroalumane;hydrate Chemical compound O.Cl[Al](Cl)Cl CAYKLJBSARHIDI-UHFFFAOYSA-K 0.000 description 2
- 229960003500 triclosan Drugs 0.000 description 2
- IIYFAKIEWZDVMP-UHFFFAOYSA-N tridecane Chemical compound CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 2
- RSJKGSCJYJTIGS-UHFFFAOYSA-N undecane Chemical compound CCCCCCCCCCC RSJKGSCJYJTIGS-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- DKBVMOJIVATKCZ-NSHDSACASA-N (2s)-2-acetamido-3-[4-[dihydroxy(methyl)silyl]oxyphenyl]propanoic acid Chemical compound CC(=O)N[C@H](C(O)=O)CC1=CC=C(O[Si](C)(O)O)C=C1 DKBVMOJIVATKCZ-NSHDSACASA-N 0.000 description 1
- PDQICKRFOKDJCH-INIZCTEOSA-N (2s)-6-amino-2-(dodecanoylamino)hexanoic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCCCN PDQICKRFOKDJCH-INIZCTEOSA-N 0.000 description 1
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- PAEMERHSTIDLSE-VEIQOZLZSA-N (3r,4s,5s,6r)-2-hexadecoxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound CCCCCCCCCCCCCCCCOC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PAEMERHSTIDLSE-VEIQOZLZSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 description 1
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
- QRWVOJLTHSRPOA-UHFFFAOYSA-N 1,3-bis(prop-2-enyl)urea Chemical compound C=CCNC(=O)NCC=C QRWVOJLTHSRPOA-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- XMFUMMRWIFOQDQ-UHFFFAOYSA-N 1-(4-methylpentan-2-yloxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOC(C)CC(C)C XMFUMMRWIFOQDQ-UHFFFAOYSA-N 0.000 description 1
- LUYCRLZBULKURT-UHFFFAOYSA-N 1-(4-methylpentan-2-yloxy)tetradecane Chemical compound CCCCCCCCCCCCCCOC(C)CC(C)C LUYCRLZBULKURT-UHFFFAOYSA-N 0.000 description 1
- 239000005968 1-Decanol Substances 0.000 description 1
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 description 1
- XZZGJYKHYBWZHR-UHFFFAOYSA-N 1-hexacosoxyhexacosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCCCCCCCCCC XZZGJYKHYBWZHR-UHFFFAOYSA-N 0.000 description 1
- BPIUIOXAFBGMNB-UHFFFAOYSA-N 1-hexoxyhexane Chemical compound CCCCCCOCCCCCC BPIUIOXAFBGMNB-UHFFFAOYSA-N 0.000 description 1
- MMMPXNOKIZOWHM-UHFFFAOYSA-N 1-octoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCC MMMPXNOKIZOWHM-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Chemical group OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- PHZSUOPYLUNLDX-UHFFFAOYSA-N 2,2-bis(prop-2-enoxy)acetic acid Chemical compound C=CCOC(C(=O)O)OCC=C PHZSUOPYLUNLDX-UHFFFAOYSA-N 0.000 description 1
- HDGQICNBXPAKLR-UHFFFAOYSA-N 2,4-dimethylhexane Chemical compound CCC(C)CC(C)C HDGQICNBXPAKLR-UHFFFAOYSA-N 0.000 description 1
- KHWCPXGTAVKMNS-UHFFFAOYSA-N 2-(2-methylprop-1-enyl)butanedioic acid Chemical compound CC(C)=CC(C(O)=O)CC(O)=O KHWCPXGTAVKMNS-UHFFFAOYSA-N 0.000 description 1
- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 description 1
- OUCGLXKNITVPJS-OUKQBFOZSA-N 2-ethylhexyl (e)-3-phenylprop-2-enoate Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=CC=C1 OUCGLXKNITVPJS-OUKQBFOZSA-N 0.000 description 1
- NKEQOUMMGPBKMM-UHFFFAOYSA-N 2-hydroxy-2-[2-(2-hydroxy-3-octadecanoyloxypropoxy)-2-oxoethyl]butanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O NKEQOUMMGPBKMM-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- ZTKXIVDCRCJOMF-UHFFFAOYSA-N 2-methyl-4-(4-methylpentan-2-yloxy)pentane Chemical compound CC(C)CC(C)OC(C)CC(C)C ZTKXIVDCRCJOMF-UHFFFAOYSA-N 0.000 description 1
- HGEMCUOAMCILCP-UHFFFAOYSA-N 2-methyldodecane Chemical compound CCCCCCCCCCC(C)C HGEMCUOAMCILCP-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 description 1
- JBVOQKNLGSOPNZ-UHFFFAOYSA-N 2-propan-2-ylbenzenesulfonic acid Chemical class CC(C)C1=CC=CC=C1S(O)(=O)=O JBVOQKNLGSOPNZ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- FDVCQFAKOKLXGE-UHFFFAOYSA-N 216978-79-9 Chemical compound C1CC(C)(C)C2=CC(C=O)=CC3=C2N1CCC3(C)C FDVCQFAKOKLXGE-UHFFFAOYSA-N 0.000 description 1
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Chemical group OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- DBLDQZASZZMNSL-QMMMGPOBSA-N 4-[(2s)-2-amino-3-hydroxypropyl]phenol Chemical compound OC[C@@H](N)CC1=CC=C(O)C=C1 DBLDQZASZZMNSL-QMMMGPOBSA-N 0.000 description 1
- IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-M 5-oxo-L-prolinate Chemical compound [O-]C(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-M 0.000 description 1
- AMEMLELAMQEAIA-UHFFFAOYSA-N 6-(tert-butyl)thieno[3,2-d]pyrimidin-4(3H)-one Chemical compound N1C=NC(=O)C2=C1C=C(C(C)(C)C)S2 AMEMLELAMQEAIA-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
- 241000157282 Aesculus Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical group O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 229910052582 BN Inorganic materials 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241000212973 Baphia Species 0.000 description 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
- NDKYEUQMPZIGFN-UHFFFAOYSA-N Butyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCC NDKYEUQMPZIGFN-UHFFFAOYSA-N 0.000 description 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- SKQOTPRMPUYWSH-FQEVSTJZSA-N CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O SKQOTPRMPUYWSH-FQEVSTJZSA-N 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 235000014653 Carica parviflora Nutrition 0.000 description 1
- 244000132059 Carica parviflora Species 0.000 description 1
- 239000001884 Cassia gum Substances 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 235000007716 Citrus aurantium Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 1
- 240000003791 Citrus myrtifolia Species 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 235000016646 Citrus taiwanica Nutrition 0.000 description 1
- HWRXYWVVYANVKE-UHFFFAOYSA-N Cl.[Na].[Na].[Na].[Na].[Na] Chemical compound Cl.[Na].[Na].[Na].[Na].[Na] HWRXYWVVYANVKE-UHFFFAOYSA-N 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
- WQZGKKKJIJFFOK-CBPJZXOFSA-N D-Gulose Chemical group OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O WQZGKKKJIJFFOK-CBPJZXOFSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-WHZQZERISA-N D-aldose Chemical group OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-WHZQZERISA-N 0.000 description 1
- WQZGKKKJIJFFOK-IVMDWMLBSA-N D-allopyranose Chemical group OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@@H]1O WQZGKKKJIJFFOK-IVMDWMLBSA-N 0.000 description 1
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Chemical group OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical group OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 125000003423 D-mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical group OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 229930091371 Fructose Chemical group 0.000 description 1
- 239000005715 Fructose Chemical group 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical group OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229920000855 Fucoidan Polymers 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 235000019487 Hazelnut oil Nutrition 0.000 description 1
- 240000008669 Hedera helix Species 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Chemical group OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 1
- 240000007839 Kleinhovia hospita Species 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VSOAQEOCSA-N L-altropyranose Chemical group OC[C@@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-VSOAQEOCSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- 102100031413 L-dopachrome tautomerase Human genes 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical group OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 235000006161 Mucuna pruriens Nutrition 0.000 description 1
- 244000111261 Mucuna pruriens Species 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- UOIBFJBJAWHQNM-JRUKXMRZSA-N N-Oleoyl tyrosine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 UOIBFJBJAWHQNM-JRUKXMRZSA-N 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 108010081810 N-undecyl-10-enoylphenylalanine Proteins 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229920002292 Nylon 6 Polymers 0.000 description 1
- PMWPXSNELQDYGB-UHFFFAOYSA-K O.[Al+3].[Br-].[Br-].[Br-] Chemical compound O.[Al+3].[Br-].[Br-].[Br-] PMWPXSNELQDYGB-UHFFFAOYSA-K 0.000 description 1
- IQKFFUNCEWRIFS-UHFFFAOYSA-G O.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].Cl.[Zr+4] Chemical compound O.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].Cl.[Zr+4] IQKFFUNCEWRIFS-UHFFFAOYSA-G 0.000 description 1
- DMYPXNKACGBCNU-UHFFFAOYSA-J O.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Zr+4] Chemical compound O.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Zr+4] DMYPXNKACGBCNU-UHFFFAOYSA-J 0.000 description 1
- ILGUBTPHYZRFEY-UHFFFAOYSA-I O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Zr+4].[Al+3] Chemical compound O.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Zr+4].[Al+3] ILGUBTPHYZRFEY-UHFFFAOYSA-I 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical group CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000008753 Papaver somniferum Nutrition 0.000 description 1
- 240000001090 Papaver somniferum Species 0.000 description 1
- 235000000370 Passiflora edulis Nutrition 0.000 description 1
- 244000288157 Passiflora edulis Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920001219 Polysorbate 40 Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 229920002651 Polysorbate 85 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- 241000218681 Pseudolarix Species 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Chemical group OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 241000605385 Ruscus Species 0.000 description 1
- 235000003500 Ruscus aculeatus Nutrition 0.000 description 1
- 240000000353 Ruscus aculeatus Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 235000008631 Santalum Nutrition 0.000 description 1
- 241001496113 Santalum Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 235000014846 Sisymbrium alliaria Nutrition 0.000 description 1
- 244000212021 Sisymbrium alliaria Species 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical group O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Chemical group 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 102000008068 Tensins Human genes 0.000 description 1
- 108010088950 Tensins Proteins 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 description 1
- 244000250129 Trigonella foenum graecum Species 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- 235000001667 Vitex agnus castus Nutrition 0.000 description 1
- 244000063464 Vitex agnus-castus Species 0.000 description 1
- 229920002000 Xyloglucan Polymers 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 description 1
- OCKWAZCWKSMKNC-UHFFFAOYSA-N [3-octadecanoyloxy-2,2-bis(octadecanoyloxymethyl)propyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)(COC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC OCKWAZCWKSMKNC-UHFFFAOYSA-N 0.000 description 1
- JYPKXWYQBSCZGE-UHFFFAOYSA-M [Na+].[O-]O.CC(C)C1=CC=CC=C1 Chemical compound [Na+].[O-]O.CC(C)C1=CC=CC=C1 JYPKXWYQBSCZGE-UHFFFAOYSA-M 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- GZCGUPFRVQAUEE-KCDKBNATSA-N aldehydo-D-galactose Chemical group OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-KCDKBNATSA-N 0.000 description 1
- 229940108929 alfalfa oil Drugs 0.000 description 1
- 229910052910 alkali metal silicate Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 125000005599 alkyl carboxylate group Chemical group 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical compound C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Chemical group OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- SRBFZHDQGSBBOR-STGXQOJASA-N alpha-D-lyxopyranose Chemical group O[C@@H]1CO[C@H](O)[C@@H](O)[C@H]1O SRBFZHDQGSBBOR-STGXQOJASA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- ZNZNMAJEWUSHPR-UHFFFAOYSA-K aluminum zirconium(4+) trichloride hydrate Chemical compound O.[Zr+4].[Cl-].[Cl-].[Cl-].[Al+3] ZNZNMAJEWUSHPR-UHFFFAOYSA-K 0.000 description 1
- YPPRKFXMPDSDJV-UHFFFAOYSA-J aluminum;sodium;2-hydroxypropanoate Chemical compound [Na+].[Al+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YPPRKFXMPDSDJV-UHFFFAOYSA-J 0.000 description 1
- GZQCBOPXKHXJPF-UHFFFAOYSA-G aluminum;zirconium(4+);heptachloride;hydrate Chemical compound O.[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Zr+4] GZQCBOPXKHXJPF-UHFFFAOYSA-G 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229940062909 amyl salicylate Drugs 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229940067599 ascorbyl glucoside Drugs 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical group OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- VQEUONXRKIUTJT-UHFFFAOYSA-N butan-2-yl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC(C)CC VQEUONXRKIUTJT-UHFFFAOYSA-N 0.000 description 1
- HUROGNYLPQBCRF-UHFFFAOYSA-N butan-2-yl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)CC HUROGNYLPQBCRF-UHFFFAOYSA-N 0.000 description 1
- OMARWWFUVFAGSK-UHFFFAOYSA-N butan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)CC OMARWWFUVFAGSK-UHFFFAOYSA-N 0.000 description 1
- RGVQDMPZABCSGD-UHFFFAOYSA-N butan-2-yl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)CC RGVQDMPZABCSGD-UHFFFAOYSA-N 0.000 description 1
- BKEUNIPSDCRXQK-UHFFFAOYSA-N butyl 16-methylheptadecanoate Chemical compound CCCCOC(=O)CCCCCCCCCCCCCCC(C)C BKEUNIPSDCRXQK-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 229940073574 c11-12 isoparaffin Drugs 0.000 description 1
- 229940095081 c13-16 isoparaffin Drugs 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 235000019318 cassia gum Nutrition 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 229910000420 cerium oxide Inorganic materials 0.000 description 1
- NEUSVAOJNUQRTM-UHFFFAOYSA-N cetylpyridinium Chemical class CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NEUSVAOJNUQRTM-UHFFFAOYSA-N 0.000 description 1
- RLGQACBPNDBWTB-UHFFFAOYSA-N cetyltrimethylammonium ion Chemical class CCCCCCCCCCCCCCCC[N+](C)(C)C RLGQACBPNDBWTB-UHFFFAOYSA-N 0.000 description 1
- 235000009347 chasteberry Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229910000423 chromium oxide Inorganic materials 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229910052570 clay Inorganic materials 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000007957 coemulsifier Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229940108925 copper gluconate Drugs 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 235000019383 crystalline wax Nutrition 0.000 description 1
- CXOCQICPRLQPQJ-UHFFFAOYSA-N cumene hydrogen peroxide thionyl dichloride Chemical compound OO.ClS(Cl)=O.CC(C)C1=CC=CC=C1 CXOCQICPRLQPQJ-UHFFFAOYSA-N 0.000 description 1
- 239000011642 cupric gluconate Substances 0.000 description 1
- 235000019856 cupric gluconate Nutrition 0.000 description 1
- 150000001924 cycloalkanes Chemical class 0.000 description 1
- YSRSBDQINUMTIF-UHFFFAOYSA-N decane-1,2-diol Chemical compound CCCCCCCCC(O)CO YSRSBDQINUMTIF-UHFFFAOYSA-N 0.000 description 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 description 1
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000008121 dextrose Chemical group 0.000 description 1
- XILPPDQAWPSZIL-UHFFFAOYSA-H dialuminum;dichloride;tetrahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[Al+3].[Al+3].[Cl-].[Cl-] XILPPDQAWPSZIL-UHFFFAOYSA-H 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 108010051081 dopachrome isomerase Proteins 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- CAMHHLOGFDZBBG-UHFFFAOYSA-N epoxidized methyl oleate Natural products CCCCCCCCC1OC1CCCCCCCC(=O)OC CAMHHLOGFDZBBG-UHFFFAOYSA-N 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UQPHVQVXLPRNCX-UHFFFAOYSA-N erythrulose Chemical compound OCC(O)C(=O)CO UQPHVQVXLPRNCX-UHFFFAOYSA-N 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- DMMXZLMYEUEJFT-UHFFFAOYSA-N ethyl 16-methylheptadecanoate Chemical compound CCOC(=O)CCCCCCCCCCCCCCC(C)C DMMXZLMYEUEJFT-UHFFFAOYSA-N 0.000 description 1
- NYNCZOLNVTXTTP-UHFFFAOYSA-N ethyl 2-(1,3-dioxoisoindol-2-yl)acetate Chemical compound C1=CC=C2C(=O)N(CC(=O)OCC)C(=O)C2=C1 NYNCZOLNVTXTTP-UHFFFAOYSA-N 0.000 description 1
- XCRHYAQWBYDRGV-UHFFFAOYSA-N ethyl 3-(4-propan-2-ylphenyl)prop-2-enoate Chemical compound CCOC(=O)C=CC1=CC=C(C(C)C)C=C1 XCRHYAQWBYDRGV-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229940068171 ethyl hexyl salicylate Drugs 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229940067592 ethyl palmitate Drugs 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229930182830 galactose Chemical group 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 229940100608 glycol distearate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 229940038487 grape extract Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 239000010468 hazelnut oil Substances 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- 229920000140 heteropolymer Polymers 0.000 description 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- FIENEGBWDWHXGG-YPKPFQOOSA-N hexyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCCCCC FIENEGBWDWHXGG-YPKPFQOOSA-N 0.000 description 1
- FPMPNVIMFPEKRN-UHFFFAOYSA-N hexyl 16-methylheptadecanoate Chemical compound CCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C FPMPNVIMFPEKRN-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- SMWDEDPRQFUXNH-UHFFFAOYSA-N hexyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCC SMWDEDPRQFUXNH-UHFFFAOYSA-N 0.000 description 1
- JIFCVUWJQMDNTN-UHFFFAOYSA-N hexyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCC JIFCVUWJQMDNTN-UHFFFAOYSA-N 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 235000010181 horse chestnut Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 150000002453 idose derivatives Chemical group 0.000 description 1
- 150000002462 imidazolines Chemical class 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 229940078546 isoeicosane Drugs 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940093629 isopropyl isostearate Drugs 0.000 description 1
- 229940033357 isopropyl laurate Drugs 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940089456 isopropyl stearate Drugs 0.000 description 1
- 239000012182 japan wax Substances 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Chemical group 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 229940031674 laureth-7 Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 230000002366 lipolytic effect Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 description 1
- 239000002370 magnesium bicarbonate Substances 0.000 description 1
- 229910000022 magnesium bicarbonate Inorganic materials 0.000 description 1
- 235000014824 magnesium bicarbonate Nutrition 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 229940063002 magnesium palmitate Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940057948 magnesium stearate Drugs 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- WPUHLWYDTKIMGG-UHFFFAOYSA-L magnesium;2-hydroxyoctadecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCC(O)C([O-])=O.CCCCCCCCCCCCCCCCC(O)C([O-])=O WPUHLWYDTKIMGG-UHFFFAOYSA-L 0.000 description 1
- ABSWXCXMXIZDSN-UHFFFAOYSA-L magnesium;hexadecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O ABSWXCXMXIZDSN-UHFFFAOYSA-L 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 150000002696 manganese Chemical class 0.000 description 1
- 229910001437 manganese ion Inorganic materials 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical class [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Chemical group OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- PABHEXWDYRTPBQ-UHFFFAOYSA-N methyl 3-[2,5-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound COC(=O)C=CC1=CC(C(C)C)=CC=C1C(C)C PABHEXWDYRTPBQ-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 229940044591 methyl glucose dioleate Drugs 0.000 description 1
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
- 229940073769 methyl oleate Drugs 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- SNVLJLYUUXKWOJ-UHFFFAOYSA-N methylidenecarbene Chemical compound C=[C] SNVLJLYUUXKWOJ-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 239000012764 mineral filler Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 150000002771 monosaccharide derivatives Chemical class 0.000 description 1
- 239000012170 montan wax Substances 0.000 description 1
- 239000008164 mustard oil Substances 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical class CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- QTDSLDJPJJBBLE-PFONDFGASA-N octyl (z)-octadec-9-enoate Chemical compound CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC QTDSLDJPJJBBLE-PFONDFGASA-N 0.000 description 1
- IIGMITQLXAGZTL-UHFFFAOYSA-N octyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCC IIGMITQLXAGZTL-UHFFFAOYSA-N 0.000 description 1
- QWPNJOHZHSJFIY-UHFFFAOYSA-N octyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCCCCCC QWPNJOHZHSJFIY-UHFFFAOYSA-N 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 229940104349 oleoyl tyrosine Drugs 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000012168 ouricury wax Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229940031709 peg-30-dipolyhydroxystearate Drugs 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 229940101027 polysorbate 40 Drugs 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229940113171 polysorbate 85 Drugs 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- GFFSHIVMOVAQMY-LMOVPXPDSA-M potassium;(2s)-2-(decanoylamino)-3-(4-hydroxyphenyl)propanoate Chemical compound [K+].CCCCCCCCCC(=O)N[C@H](C([O-])=O)CC1=CC=C(O)C=C1 GFFSHIVMOVAQMY-LMOVPXPDSA-M 0.000 description 1
- PZQSQRCNMZGWFT-QXMHVHEDSA-N propan-2-yl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC(C)C PZQSQRCNMZGWFT-QXMHVHEDSA-N 0.000 description 1
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- FTBUKOLPOATXGV-UHFFFAOYSA-N propyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCC FTBUKOLPOATXGV-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- BTAXGNQLYFDKEF-UHFFFAOYSA-N propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCC BTAXGNQLYFDKEF-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- DPBVJRXPSXTHOL-UHFFFAOYSA-N propyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCC DPBVJRXPSXTHOL-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 229940071139 pyrrolidone carboxylate Drugs 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 239000012313 reversal agent Substances 0.000 description 1
- 239000006254 rheological additive Substances 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 229960005265 selenium sulfide Drugs 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000004296 sodium metabisulphite Substances 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- NTVDGBKMGBRCKB-UHFFFAOYSA-M sodium;12-hydroxyoctadecanoate Chemical compound [Na+].CCCCCCC(O)CCCCCCCCCCC([O-])=O NTVDGBKMGBRCKB-UHFFFAOYSA-M 0.000 description 1
- NGSRGPMIUOKCKY-UHFFFAOYSA-M sodium;2,2-bis(prop-2-enoxy)acetate Chemical compound [Na+].C=CCOC(C(=O)[O-])OCC=C NGSRGPMIUOKCKY-UHFFFAOYSA-M 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940057429 sorbitan isostearate Drugs 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 229950003429 sorbitan palmitate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000020712 soy bean extract Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 229940071136 stearoyl glutamate Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Chemical group 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 229940061605 tetrasodium glutamate diacetate Drugs 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 150000003611 tocopherol derivatives Chemical class 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229940087291 tridecyl alcohol Drugs 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical compound OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 description 1
- 239000002383 tung oil Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-L tyrosinate(2-) Chemical compound [O-]C(=O)C(N)CC1=CC=C([O-])C=C1 OUYCCCASQSFEME-UHFFFAOYSA-L 0.000 description 1
- 125000005065 undecenyl group Chemical group C(=CCCCCCCCCC)* 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- GDJZZWYLFXAGFH-UHFFFAOYSA-M xylenesulfonate group Chemical group C1(C(C=CC=C1)C)(C)S(=O)(=O)[O-] GDJZZWYLFXAGFH-UHFFFAOYSA-M 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/56—Glucosides; Mucilage; Saponins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/24—Homopolymers or copolymers of amides or imides
- C09D133/26—Homopolymers or copolymers of acrylamide or methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/017—Mixtures of compounds
- C09K23/018—Mixtures of two or more different organic oxygen-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/16—Amines or polyamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Wood Science & Technology (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及一种自可逆反相胶乳,该自可逆反相胶乳包含:作为反相剂的烷基聚糖苷家族的表面活性剂物种,其烷基链包含从8至18个碳原子,具有低残留脂肪醇含量;其作为增稠剂和/或乳化剂和/或稳定剂用于化妆品、皮肤药物或药物局部组合物的用途以及包含其的化妆品、皮肤药物或药物局部组合物。
Description
本发明涉及自可逆反相胶乳,其包含作为反相剂的含有烷基聚糖苷的表面活性剂组合物,涉及所述自可逆反相胶乳作为增稠剂用于制备化妆品、皮肤美容、皮肤药物和药物配制品的用途,并且还涉及这些配制品。
包含极性相(例如水-醇或水-醇相)的化妆品、皮肤美容、皮肤药物和药物组合物经常需要使用流变改性聚合物以增加其所述极性相的粘度,并且更普遍地赋予它们特定的流变性行为。
在可用于制备这些组合物的流变改性剂之中,可以提及合成聚合物,例如直链或支链、交联或非交联的阴离子、或阳离子或两性的聚电解质,其为两种物理形式:即粉末形式和液体形式。
所述化妆品、皮肤美容、皮肤药物和药物组合物通常为水凝胶、水-醇凝胶、水-乙二醇凝胶、油包水型或水包油型或水包油包水型或油包水包油型乳液或微乳液或纳米乳液的形式,或化妆品、皮肤美容、药物以及和皮肤药物工业中通常使用的任何其他呈递形式。
在通过使用反相乳液自由基聚合制备自可逆反相胶乳的方法中,在聚合步骤结束时添加水包油型表面活性剂。添加它们的目的是改变并调节包含聚合物的油包水乳液(也称为“反相胶乳”)的亲水-亲脂平衡,以便获得一种混合物,当将该混合物添加到极性相(例如水)中时,将改变乳液的方向以从油包水形式转变为水包油形式,然后使得可以将先前制备的聚合物与有待增稠的极性相接触。在这种物理现象期间,交联和/或支化聚电解质类型的聚合物被部署在所述极性相中并形成允许极性相溶胀的三维网络,这通过该极性相的粘度增加而表现出来。
包含“反相胶乳”和水包油型表面活性剂的混合物被称为自可逆反相胶乳并且所述水包油型表面活性剂被称为“反相物”或“反相剂”。
通常用于制备自可逆反相胶乳的反相剂是水包油型表面活性剂,其HLB(亲水-亲脂平衡)值足够高以使得制备稳定的水包油型乳液,通常是大于9且小于16。它们通常包含由一系列环氧乙烷单元组成的亲水部分以及由具有疏水性质的基于烃的脂族链组成的部分。在这些反相剂中,可以提及:
-乙氧基化的脂肪醇,其基于烃的脂族链包含从8至14个碳原子,并且其中环氧乙烷单元的数目是在5与40之间,例如用7mol环氧乙烷乙氧基化的月桂醇(INCI名称:月桂醇聚醚-7)或含有6mol环氧乙烷的十三烷醇(INCI名称:十三烷醇聚醚-6);
-乙氧基化的脱水山梨醇酯,其基于烃的脂族链包含从12至22个碳原子并且其中环氧乙烷单元的数目是在5与40之间,例如用20mol的环氧乙烷乙氧基化的脱水山梨醇油酸酯(以商品名MontanoxTM 80销售),或用20mol的环氧乙烷乙氧基化的脱水山梨糖醇月桂酸酯(以商品名MontanoxTM 20销售);
乙氧基化的烷基酚,例如乙氧基化的壬基酚和乙氧基化的辛基酚;或
乙氧基化的蓖麻油,例如用40mol的环氧乙烷乙氧基化的蓖麻油(以商标名SimulsolTM OL 50销售)。
消费者需求及法规规定的变化导致化妆品组合物配方设计师降低了其配制品中包括环氧乙烷单元的成分的比例。因此,需要制备不含乙氧基化的表面活性剂作为反相剂的自可逆反相胶乳。
以编号2 794 034、2 794 124、2 808 447、2 808 446和2 810 883公开的法国专利申请描述了使用烷基聚糖苷,其基于烃的烷基链包括约30个碳原子,例如其基于烃的烷基链为癸基、十二烷基和十四烷基链的烷基聚糖苷的混合物,例如以商标名SimulsolTM SL10销售的混合物,为十二烷基、十四烷基和十六烷基链的烷基聚糖苷的混合物,例如以商标名SimulsolTM SL 26销售的混合物,为辛基和癸基链的烷基聚糖苷的混合物,例如以商标名SimulsolTM SL 8销售的混合物,或为十一碳烯基链的烷基聚糖苷的混合物,例如以商标名SimulsolTM SL 11 W销售的混合物。
然而,用于制备自可逆反相胶乳的此类化合物的实施必须在高于其熔点的温度下进行,即通常在高于70℃的温度下进行,这带来了反相胶乳不稳定的问题并且引起一定量的制备的自可逆反相胶乳不稳定。在某些情况下,通过将所述烷基聚糖苷预先稀释在水中以具有可以在室温下处理的液体形式来进行。有时这具有降低要增稠的极性相中所述自可逆反相胶乳的转化率的结果,并因此降低了制备包含此类增稠剂的化妆品配制品的方法的生产率。
因此,仍然需要开发水包油型表面活性剂体系,其构成表面活性剂表现出令人满意的环境标准顺应性,特别是由于不含环氧烷单元(例如环氧乙烷单元),并且使得可以制备可以易于使用并且特别是可以在25℃下泵送的自可逆反相胶乳,其粘度小于或等于8000mPa.s、优选小于或等于5000mPa.s,该粘度是使用Brookfield RVT粘度计和3号轴(spindle)在25℃下以20rpm的旋转速度测量的,其外观光滑,无颗粒或结块,并且在极性相中具有良好的反转特性,即引起小于15分钟、优选小于10分钟的快速反相速率,使得包含在自可逆反相胶乳中的聚合物能够表现出其全部增稠能力。
根据第一方面,本发明的主题是一种油包水型乳液(E),包含基于100%其质量:
a)-从10质量%至80质量%衍生自以下项的聚合的交联的聚合物(P),基于100mol%:
(a1)-大于或等于30mol%且小于或等于100mol%比例的衍生自带有部分盐化或完全盐化的强酸官能团的单体的单体单元;以及
(a2)-任选地大于0mol%且小于或等于70mol%比例的衍生自至少一种单体的单体单元:该单体选自由以下组成的组的元素:丙烯酸、甲基丙烯酸、衣康酸、马来酸、3-甲基-3-[(1-氧代-2-丙烯基)氨基]丁酸、所述单体的羧酸官能团是以部分盐化或完全盐化的酸形式,和/或选自由以下组成的组的元素:(2-羟乙基)丙烯酸酯、(2,3-二羟丙基)丙烯酸酯、(2-羟乙基)甲基丙烯酸酯、(2,3-二羟丙基)甲基丙烯酸酯或乙烯基吡咯烷酮;
(a3)-大于0mol%且小于或等于1mol%比例的衍生自至少一种二烯键或多烯键交联单体(AR)的单体单元;
应当理解,这些单体单元(a1)、(a2)和(a3)的摩尔比例之和是等于100%;
b)-从5质量%至50质量%、更特别地从5质量%至45质量%并且甚至更特别地从5质量%至40质量%的由至少一种油(H)组成的脂肪相,以及
c)-从1质量%至50质量%、更特别地从5质量%至45质量%并且甚至更特别地从5质量%至40质量%的水,以及
d)-从0.5质量%至10质量%、更特别地从0.5质量%至8质量%并且甚至更特别地从0.5质量%至7质量%的油包水型乳化体系(S1),以及
e)-从2质量%至10质量%、更特别地从2质量%至8质量%并且甚至更特别地从4质量%至7质量%的水包油型乳化体系(S2),该水包油型乳化体系包含基于100%其质量至少50质量%的组合物(Ce),该组合物包含基于100%其质量:
e1)-大于或等于20质量%且小于或等于80质量%比例的式(I)的稀释剂:
HO-[CH2-CH(OH)-CH2-O-]n-H (I),
其中n是大于或等于1且小于或等于6的整数,或所述稀释剂的混合物,
e2)-大于或等于20质量%且小于或等于80质量%的比例的组合物(Ce2),该组合物包含基于100%其质量:
e2α)-大于0质量%且小于或等于4质量%的比例的至少一种式(II)的醇:
CmH2m+1-OH (II),
其中m是大于或等于8且小于或等于18的偶数整数;
e2β)-大于或等于96质量%且小于100质量%比例的组合物(C2β),包含:
e2β2)-大于或等于60质量%且小于或等于90质量%比例的组合物(C2β2),该组合物包含基于100%其质量:
e2β21)-大于或等于5质量%且小于或等于20质量%比例的由式(III)表示的组合物(C21):
R21-O-(G21)r-H (III),
其中R21表示正十二烷基,G21表示还原糖残基,并且r表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C21)由式(III1)、(III2)、(III3)、(III4)和(III5)的化合物的混合物组成:
R21-O-(G21)1-H (III1),
R21-O-(G21)2-H (III2),
R21-O-(G21)3-H (III3),
R21-O-(G21)4-H (III4),
R21-O-(G21)5-H (III5),
所述式(III1)、(III2)、(III3)、(III4)和(III5)的化合物的摩尔比例分别等于a1、a2、a3、a4和a5,使得a1+a2+a3+a4+a5之和等于1,并且使得a1+2a2+3a3+4a4+5a5之和等于r;
e2β22)-大于或等于10质量%且小于或等于20质量%比例的由式(IV)表示的组合物(C22):
R22-O-(G22)s-H (IV),
其中R22表示正十四烷基,G22表示还原糖残基,并且s表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C22)由式(IV1)、(IV2)、(IV3)、(IV4)和(IV5)的化合物的混合物组成:
R22-O-(G22)1-H (IV1),
R22-O-(G22)2-H (IV2),
R22-O-(G22)3-H (IV3),
R22-O-(G22)4-H (IV4),
R22-O-(G22)5-H (IV5),
所述式(IV1)、(IV2)、(IV3)、(IV4)和(IV5)的化合物的摩尔比例分别等于b1、b2、b3、b4和b5,使得b1+b2+b3+b4+b5之和等于1,并且使得b1+2b2+3b3+4b4+5b5之和等于s;
e2β23)-大于或等于25质量%且小于或等于40质量%比例的由式(V)表示的组合物(C23):
R23-O-(G23)q-H (V)
其中R23表示正辛基,G23表示还原糖残基,并且t表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C23)由式(V1)、(V2)、(V3)、(V4)和(V5)的化合物的混合物组成:
R23-O-(G23)1-H (V1),
R23-O-(G23)2-H (V2),
R23-O-(G23)3-H (V3),
R23-O-(G23)4-H (V4),
R23-O-(G23)5-H (V5),
所述式(V1)、(V2)、(V3)、(V4)和(V5)的化合物的摩尔比例分别等于c1、c2、c3、c4和c5,使得c1+c2+c3+c4+c5之和等于1,
并且使得c1+2c2+3c3+4c4+5c5之和等于t;
e2β24)-大于或等于30质量%且小于或等于55质量%的质量比例的由式(VI)表示的组合物(C24):
R24-O-(G24)u-H (VI),
其中R24表示正癸基,G24表示还原糖残基并且u表示大于或等于1.05且小于或等于5.00的十进制数,
所述组合物(C24)由式(VI1)、(VI2)、(VI3)、(VI4)和(VI5)的化合物的混合物组成:
R24-O-(G24)1-H (VI1),
R24-O-(G24)2-H (VI2),
R24-O-(G24)3-H (VI3),
R24-O-(G24)4-H (VI4),
R24-O-(G24)5-H (VI5),
所述式(VI1)、(VI2)、(VI3)、(VI4)和(VI5)的化合物的摩尔比例分别等于d1、d2、d3、d4和d5,使得d1+d2+d3+d4+d5之和等于1,并且使得d1+2d2+3d3+4d4+5d5之和等于u;
应当理解,组合物(C21)、(C22)、(C23)和(C24)的质量比例之和等于100%;
e2β3)-大于或等于10质量%且小于或等于40质量%比例的组合物(C2β3),包含基于100%其质量:
e2β31)-大于或等于30质量%且小于或等于50质量%比例的由式(VII)表示的组合物(C31):
R31-O-(G31)x-H (VII)
其中R31表示正十六烷基,
G31表示还原糖残基并且x表示大于或等于1.05且小于或等于5.00的十进制数,
所述组合物(C31)由式(VII1)、(VII2)、(VII3)、(VII4)和(VII5)的化合物的混合物组成:
R31-O-(G31)1-H (VII1),
R31-O-(G31)2-H (VII2),
R31-O-(G31)3-H (VII3),
R31-O-(G31)4-H (VII4),
R31-O-(G31)5-H (VII5),
所述式(VII1)、(VII2)、(VII3)、(VII4)和(VII5)的化合物的摩尔比例分别等于a’1、a’2、a’3、a’4和a’5,使得a’1+a’2+a’3+a’4+a’5之和等于1,并且使得a’1+2a’2+3a’3+4a’4+5a’5之和等于x;
e2β32)-大于或等于50质量%且小于或等于70质量%比例的由式(VIII)表示的组合物(C32):
R32-O-(G32)y-H (VIII),
其中R32表示正十八烷基,G32表示还原糖残基并且y表示大于或等于1.05且小于或等于5.00的十进制数,
所述组合物(C32)由式(VIII1)、(VIII2)、(VIII3)、(VIII4)和(VIII5)的化合物的混合物组成:
R32-O-(G32)1-H (VIII1),
R32-O-(G32)2-H (VIII2),
R32-O-(G32)3-H (VIII3),
R32-O-(G32)4-H (VIII4),
R32-O-(G32)5-H (VIII5),
所述式(VIII1)、(VIII2)、(VIII3)、(VIII4)和(VIII5)的化合物的摩尔比例分别等于b’1、b’2、b’3、b’4和b’5,使得b’1+b’2+b’3+b’4+b’5之和等于1,并且使得b’1+2b’2+3b’3+4b’4+5b’5之和等于y,
应当理解,组合物(C31)和(C32)的质量比例之和等于100%;并且
应当理解,化合物(a)、(b)、(c)、(d)和(e)的质量比例之和是等于100%。
为了本发明的目的,术语“交联的聚合物”对于聚合物(P)是指非线性聚合物,当添加到水中时,它是呈不溶于水的三维网络的形式,但是在水中可溶胀,然后导致产生化学凝胶。
为了本发明的目的,在如前定义的聚合物(P)中,术语“盐化”意指存在于单体中的强酸官能团是与阳离子盐化形式的缔合阴离子形式,该阳离子特别是碱金属盐,如钠或钾阳离子,或如含氮碱的阳离子,如铵盐,赖氨酸盐或单乙醇胺盐(HO-CH2-CH2-NH4 +)。
包括其的单体的强酸官能团特别是磺酸官能或膦酸官能团。所述单体是例如部分或完全盐化的苯乙烯磺酸,或优选地,部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸。
根据本发明的特定方面,带有强酸官能团的单体是2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸,并且更特别地2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸的钠或铵盐。
根据本发明的另一个特定方面,所述交联的聚合物(P)是衍生自以下项的聚合,基于100mol%:
(a1)-大于或等于40mol%且小于或等于100mol%比例的衍生自带有部分盐化或完全盐化的强酸官能团的单体的单体单元,
根据本发明的第一特定替代方案,所述交联的聚合物(P)是部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸的交联的均聚物。
根据本发明的第二特定替代方案,所述交联的聚合物(P)是部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸和至少一种选自以下单体的交联的共聚物:丙烯酸、部分或完全盐化的甲基丙烯酸、(2-羟乙基)丙烯酸酯、(2,3-二羟丙基)丙烯酸酯、(2-羟乙基)甲基丙烯酸酯、(2,3-二羟丙基)甲基丙烯酸酯和乙烯基吡咯烷酮。
根据本发明的另一个特定方面,如上定义的油包水型乳液(E)包含从20质量%至80质量%并且更特别地从30质量%至80质量%的所述聚合物(P)。
当所述聚合物(P)是交联的共聚物时,其特别是衍生自以下项的聚合,基于100mol%,
(a1)-大于或等于40mol%且小于100mol%比例的衍生自带有部分盐化或完全盐化的强酸官能团的单体的单体单元;以及
(a2)-大于0mol%且小于或等于60mol%比例的衍生自至少一种单体的单体单元:该单体选自由以下组成的组的元素:丙烯酸、甲基丙烯酸、衣康酸、马来酸、3-甲基-3-[(1-氧代-2-丙烯基)氨基]丁酸、所述单体的羧酸官能团是以部分盐化或完全盐化的酸形式,和/或选自由以下组成的组的元素:(2-羟乙基)丙烯酸酯、(2,3-二羟丙基)丙烯酸酯、(2-羟乙基)甲基丙烯酸酯、(2,3-二羟丙基)甲基丙烯酸酯或乙烯基吡咯烷酮;
(a3)-大于0mol%且小于或等于1mol%比例的衍生自至少一种二烯键或多烯键交联单体(AR)的单体单元;
应当理解,这些单体单元(a1)、(a2)和(a3)的摩尔比例之和是等于100%。
在作为本发明主题的油包水型乳液(E)的定义中,术语“至少一种二烯键或多烯键交联单体(AR)”表示特别选自以下的单体:乙二醇二甲基丙烯酸酯、二乙二醇二丙烯酸酯、乙二醇二丙烯酸酯、二烯丙基脲、三烯丙基胺、三羟甲基丙烷三丙烯酸酯、亚甲基双(丙烯酰胺)或这些化合物的混合物、二烯丙氧基乙酸或其盐如二烯丙氧基乙酸钠或这些化合物的混合物。
根据另一个特定方面,交联单体(AR)选自乙二醇二甲基丙烯酸酯、三烯丙基胺、三羟甲基丙烷三丙烯酸酯和亚甲基双(丙烯酰胺)。
根据另一个特定方面,交联单体(AR)以小于或等于0.5%、更特别地小于或等于0.25%并且最特别地小于或等于0.1%的摩尔比例使用;它更特别地是大于或等于0.005mol%。
在本发明的上下文中可以提及的交联的聚合物(P)的实例更具体地包括:
-以钠盐或铵盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸与三烯丙基胺和/或亚甲基双(丙烯酰胺)交联的均聚物;
-以钠盐或铵盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸和(2-羟乙基)丙烯酸酯与三烯丙基胺和/或亚甲基双(丙烯酰胺)交联的共聚物;
-以钠盐或铵盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸和丙烯酸与三烯丙基胺和/或亚甲基双(丙烯酰胺)交联的共聚物;
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和(2-羟乙基)丙烯酸酯(δ)以在30/70与90/10之间(γ)/(δ)摩尔比的交联的共聚物;
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和(2-羟乙基)丙烯酸酯(δ)以在40/60与90/10之间(γ)/(δ)摩尔比的交联的共聚物;
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和以钠盐形式部分或完全盐化的丙烯酸(ε),以大于或等于30/70且小于或等于90/10(γ)/(ε)摩尔比的交联的共聚物;以及
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和以钠盐形式部分或完全盐化的丙烯酸(ε),以大于或等于40/60且小于或等于90/10(γ)/(ε)摩尔比的交联的共聚物。
在作为本发明主题的油包水型乳液(E)的定义中,术语“油”表示油(H),特别地:
-包含从11至19个碳原子的直链烷烃,
-包含从7至40个碳原子的支链烷烃,例如异十二烷、异十五烷、异十六烷)、异十七烷、异十八烷、异十九烷或异二十烷或其某些混合物,如以下提及并以其INCI名称标识的那些:C7-8异链烷烃、C8-9异链烷烃、C9-11异链烷烃、C9-12异链烷烃、C9-13异链烷烃、C9-14异链烷烃、C9-16异链烷烃、C10-11异链烷烃、C10-12异链烷烃、C10-13异链烷烃、C11-12异链烷烃、C11-13异链烷烃、C11-14异链烷烃、C12-14异链烷烃、C12-20异链烷烃、C13-14异链烷烃、C13-16异链烷烃;
-任选地被一个或多个直链或支链烷基取代的环烷烃,
-白色矿物油,如以以下名称销售的产品:MarcolTM 52、MarcolTM 82、DrakeolTM6VR、EolaneTM 130、EolaneTM150,
-半角鲨烷(或2,6,10-三甲基十二烷;CAS编号:3891-98-3)、角鲨烷(或2,6,10,15,19,23-六甲基二十四烷)、氢化聚异丁烯或氢化聚癸烯;
-式(IX)的脂肪醇醚:
Z1-O-Z2 (IX),
其中Z1和Z2可以相同或不同,表示包括从5至18个碳原子的直链或支链烷基,例如二辛基醚、二癸基醚、十二烷基醚、十二烷基辛基醚、二十六烷基醚、(1,3-二甲基丁基)十四烷基醚、(1,3-二甲基丁基)十六烷基醚、双(1,3-二甲基丁基)醚或二己基醚;
-脂肪酸和式(X)的醇的单酯:
R″1-(C=O)-O-R″2 (X),
其中R″1-(C=O)表示包括从8至24个碳原子的饱和或不饱和的、直链或支链的酰基,并且R″2独立于R″1表示包含从1至24个碳原子的饱和或不饱和的、直链或支链的基于烃的链,例如月桂酸甲酯、月桂酸乙酯、月桂酸丙酯、月桂酸异丙酯、月桂酸丁酯、月桂酸2-丁酯、月桂酸己酯、椰油酸甲酯、椰油酸乙酯、椰油酸丙酯、椰油酸异丙酯、椰油酸丁酯、椰油酸2-丁酯、椰油酸己酯、肉豆蔻酸甲酯、肉豆蔻酸乙酯、肉豆蔻酸丙酯、肉豆蔻酸异丙酯、肉豆蔻酸丁酯、肉豆蔻酸2-丁酯、肉豆蔻酸己酯、肉豆蔻酸辛酯、棕榈酸甲酯、棕榈酸乙酯、棕榈酸丙酯、棕榈酸异丙酯、棕榈酸丁酯、棕榈酸2-丁酯、棕榈酸己酯、棕榈酸辛酯、油酸甲酯、油酸乙酯、油酸丙酯、油酸异丙酯、油酸丁酯、油酸2-丁酯、油酸己酯、油酸辛酯、硬脂酸甲酯、硬脂酸乙酯、硬脂酸丙酯、硬脂酸异丙酯、硬脂酸丁酯、硬脂酸2-丁酯、硬脂酸己酯、硬脂酸辛酯、异硬脂酸甲酯、异硬脂酸乙酯、异硬脂酸丙酯、异硬脂酸异丙酯、异硬脂酸丁酯、异硬脂酸2-丁酯、异硬脂酸己酯、异硬脂酸异硬脂酯;
-式(XI)和式(XII)的脂肪酸和甘油的二酯:
R″3-(C=O)-O-CH2-CH(OH)-CH2-O-(C=O)-R″4 (XI)
R″5-(C=O)-O-CH2-CH[O-(C=O)-R″6]-CH2-OH (XII),
在式(XI)和(XII)中,R″3-(C=O)、R″4-(C=O)、R″5-(C=O)和R″6-(C=O)可以相同或不同,表示包括从8至24个碳原子的饱和或不饱和的、直链或支链的酰基;
-式(XIII)的脂肪酸和甘油的三酯:
R″7-(C=O)-O-CH2-CH[O-(C=O)-R″8]-CH2-O-(C=O)-R″9 (XII),
其中R″7-(C=O)、R″8-(C=O)和R″9-(C=O),可以相同或不同,表示包括从8至24个碳原子的饱和或不饱和的、直链或支链的酰基。
根据本发明的另一个特定方面,所述油(H)选自:
-十一烷、十三烷、异十二烷或异十六烷,
-以名称EmogreenTM L15、EmogreenTM L19、EmosmartTM L15、EmosmartTM L19、EmosmartTM V21、IsoparTM L或IsoparTM M销售的烷烃、异烷烃和环烷烃的混合物;
-以名称MarcolTM 52、MarcolTM 82、DrakeolTM 6VR、EolaneTM 130或EolaneTM150销售的白色矿物油;
-半角鲨烷、角鲨烷、氢化聚异丁烯或氢化聚癸烯;
-二辛基醚或二癸基醚;
-肉豆蔻酸异丙酯,棕榈酸己酯,棕榈酸辛酯,异硬脂酸异硬脂酯,辛酰基/癸酰基甘油三酸酯,十六烷酰基/十八烷酰基甘油三酸酯和从菜籽油、葵花籽油、亚麻籽油或棕榈油衍生的甘油三酸酯。
在作为本发明主题的油包水型乳液(E)中,油包水型的乳化体系(S1)由单一乳化表面活性剂或乳化表面活性剂的混合物组成,条件是所述混合物的HLB值足够低以致形成油包水型乳液。作为油包水型的乳化表面活性剂,可以提及的实例包括脱水己糖醇与包括从12至22个碳原子的任选地被一个或多个羟基取代的直链或支链的、饱和或不饱和的脂族羧酸的酯,并且更特别选自脱水山梨糖醇和脱水甘露糖醇的脱水己糖醇与包括从12至22个碳原子的任选地被一个或多个羟基取代的直链或支链、饱和或不饱和的脂族羧酸的酯。
在作为本发明主题的油包水型乳液(E)中,油包水型乳化体系(S1)更特别地选自由以下组成的组的元素:脱水山梨糖醇月桂酸酯,例如,以名称MontaneTM 20出售的产品,脱水山梨糖醇棕榈酸酯,例如以名称MontaneTM 40出售的产品,脱水山梨糖醇硬脂酸酯,例如以名称MontaneTM 60出售的产品,脱水山梨糖醇油酸酯,例如以名称MontaneTM 80出售的产品,脱水山梨糖醇倍半油酸酯,例如以名称MontaneTM 85的出售的产品,脱水山梨糖醇三油酸酯,例如以名称MontaneTM 83出售的产品,脱水山梨糖醇异月桂酸酯,脱水山梨糖醇异硬脂酸酯,例如以名称MontaneTM 70出售的产品,甘露醇酐月桂酸酯,甘露醇酐油酸酯或这些酯的混合物;分子量在1000与3000之间并且衍生自聚(异丁烯基)琥珀酸或其酸酐之间的缩合的聚酯,如HypermerTM 2296,或以商标名SimalineTM IE 501 A出售的混合物,式(XIV)的聚乙二醇聚羟基硬脂酸酯:
其中y2表示大于或等于2且小于或等于50的整数,Z4表示氢原子、甲基或乙基,Z3表示式(XV)的基团:
其中y′2表示大于或等于0且小于或等于10,更特别地大于或等于1且小于或等于10的整数并且Z′2表示如上定义的式(XV)的基团,其中Z2’可以与Z2相同或不同或是氢原子。
可用于制备乳化体系(S1)的式(XIV)的油包水型乳化表面活性剂的实例包括以名称SimalineTM WO的出售的PEG-30二聚羟基硬脂酸酯,或另外包含PEG-30二聚羟基硬脂酸酯并以名称SimalineTM IE 201 A和SimalineTM IE 201 B出售的混合物,或者另外包含三羟甲基丙烷-30三聚羟基硬脂酸酯以名称SimalineTM IE 301 B出售的混合物。
根据本发明的另一个特定方面,所述水包油型乳化体系(S2)包含基于100%其质量至少75质量%的如前定义的组合物(Ce)。根据最特定的方面,所述水包油型乳化体系(S2)是如前定义的组合物(Ce)。
在作为本发明主题的所述油包水型乳液(E)的定义中,术语“式(I)的稀释剂”特别是指甘油、二甘油、三甘油或六甘油。
根据本发明的另一个特定方面,所述稀释剂的特征在于在式(I)中,n表示大于或等于1且小于或等于3的整数。根据最特定的方面,n是等于1。
根据本发明的另一个特定方面,如前定义的所述油包水型乳液(E)的特征在于在式(III)、(IV)、(V)、(VI)、(VII)和(VIII)中,G21、G22、G23、G24、G31和G32可以相同或不同,彼此独立地表示选自葡萄糖、右旋糖、蔗糖、果糖、艾杜糖、古洛糖、半乳糖、麦芽糖、异麦芽糖、麦芽三糖、乳糖、纤维二糖、甘露糖、核糖、木糖、阿拉伯糖、来苏糖、阿洛糖、阿卓糖、葡聚糖和塔罗糖的还原糖残基。所述还原糖残基G21、G22、G23、G24、G31和G32可以相同或不同,更特别地选自葡萄糖、木糖和阿拉伯糖残基。
根据本发明的更特定方面,如前定义的所述油包水型乳液(E)的特征在于在式(III)、(IV)、(V)和(VI)中,所述还原糖残基G21、G22、G23和G24是相同的并且表示葡萄糖残基、木糖残基或阿拉伯糖残基,并且最特别地表示葡萄糖残基或木糖残基。
根据本发明的非常特定方面,如前定义的所述油包水型乳液(E)的特征在于在式(III)、(IV)、(V)和(VI)中,所述还原糖残基G21、G22、G23和G24是相同的并且表示葡萄糖残基。
根据本发明的另一个特定方面,如前定义的所述油包水型乳液(E)的特征在于在式(III)、(IV)、(V)和(VI)中,r、s、t和u分别彼此独立地表示大于或等于1.05且小于或等于2.5的十进制数;在这种情况下,该十进制数通常小于或等于2.0,并且例如大于或等于1.25且小于或等于2.0。
根据本发明的另一个更特定方面,如前定义的所述油包水型乳液(E)的特征在于在式(VII)和(VIII)中,所述还原糖残基G31和G32表示选自葡萄糖残基、木糖残基和阿拉伯糖残基的相同还原糖残基,并且最特别地表示葡萄糖残基或木糖残基。
根据本发明的非常特定方面,如前定义的所述油包水型乳液(E)的特征在于在式(VII)和(VIII)中,所述还原糖残基G31和G32是相同的并且表示葡萄糖残基。
根据本发明的另一个更特定方面,如前定义的所述油包水型乳液(E)的特征在于在式(VII)和(VIII)中,x和y分别表示大于或等于1.05且小于或等于2.5的十进制数;在这种情况下,该十进制数通常小于或等于2.0,并且例如大于或等于1.25且小于或等于2.0。
根据本发明的另一个特定方面,如前定义的所述油包水型乳液(E)的特征在于质量比:
Δ=组合物(C2β2)的质量/组合物(C2β3)的质量,
大于或等于1且小于或等于10,更特别地大于或等于1.0且小于或等于8.0,最特别地大于或等于1.5且小于或等于7.0,例如大于或等于2.0且小于或等于7.0。
作为本发明主题的所述油包水型乳液(E)是通过进行“反相乳液聚合”方法制备的,该方法是本领域技术人员众所周知的,并且包括以下步骤:
-步骤a)制备包含以下项的水相:水、水溶性单体和任选的交联单体(AR)以及还有常用添加剂,例如螯合剂,如其钠盐形式的乙二胺四乙酸或二亚乙基三胺五乙酸的五钠盐酸(以商标名VersenexTM 80销售);
-步骤b)将油相(H)与油包水型乳化体系(S1)混合;
-步骤c)将在先前步骤中制备的水相和油相混合,并使用转子-定子型的轴进行乳化;
-步骤d)用氮气惰性化;
-步骤e)通过将自由基引发剂和任选的共引发剂引入c)中形成的乳液中来引发聚合反应;然后使反应进行;
-步骤f)在低于50℃的温度下引入如前定义的水包油型乳化体系(S2)。
根据如前定义的方法的特定方面,步骤e)的聚合反应使用产生亚硫酸氢根离子(HSO3 -)的氧化还原对,如枯烯氢过氧化物-焦亚硫酸钠(Na2S2O5)对或枯烯氢过氧化物-亚硫酰氯(SOCl2)对在小于或等于10℃的温度下,如果需要的话还伴有聚合共引发剂,例如偶氮双(异丁腈)引发,并且然后准绝热地进行,直至温度大于或等于到50℃,或通过控制温度进行。
根据如前定义的方法的另一个特定方面,在进行步骤f)之前,将来自步骤e)的反应介质通过蒸馏进行浓缩。
根据如前定义的方法的另一个特定方面,将来自步骤e)或步骤f)的反应介质在适当的装置中雾化。根据如前定义的方法的另一个特定方面,步骤a)中制备的水相可包含链减少剂,其旨在减少形成的聚合物链的长度并增加聚合物的支化度,从而改变流变特性。
在适用于如前定义的方法中的链减少剂之中,可以提及甲醇、异丙醇、丁二醇、2-巯基乙醇、巯基乙酸和甲酸、或其盐。
水包油型乳化体系(S2)中包含的组合物(Ce)是根据包括以下步骤的方法制备的:
-步骤A)以所需比例使式(XVI)的还原糖或式(XVI)的还原糖的混合物:
HO-(G)-H (XVI)
其中G表示还原糖残基,与摩尔过量的如前定义的式(II)的醇的混合物反应:
CmH2m+1-OH (II),
以形成如前定义的式(III)、
(IV)、(V)、(VI)、(VII)和(VIII)的化合物的混合物和过量的所述式(II)的醇的混合物,
-步骤B)部分除去过量的所述式
(II)的醇的混合物,以形成如前定义的所述组合物(Ce2);
-步骤C)将所述组合物(Ce2)与至少一种如前定义的稀释剂混合。
步骤A)通常在反应器中、在酸性催化体系存在下,通过控制两种试剂之间的化学计量比,并且更特别地通过引入摩尔过量的式(II)的醇混合物,伴随机械搅拌,在预定温度和部分真空条件下,例如在70℃与130℃之间的温度下以及在300毫巴(3×104Pa)与20毫巴(2×103Pa)之间的部分真空下进行。术语“酸性催化体系”表示强酸,如硫酸、盐酸、磷酸、硝酸、次磷酸、甲磺酸、对-甲苯磺酸、三氟甲磺酸,或离子交换树脂。
如上定义的方法还可以包括中和、过滤和脱色操作。
本发明的主题还是如前定义的油包水型乳液(E)作为增稠剂和/或乳化剂和/或稳定剂用于化妆品、皮肤药物或药物局部组合物的用途。
根据特定方面,所述用途在于增稠极性相,例如水性、醇相或水-醇相或包含多元醇如甘油的极性相。
根据另一个特定方面,所述用途在于稳定水包油型或油包水型乳液,使所述乳液在各种条件下的储存期间,并且更特别地在25℃下至少等于一个月,并且更特别地在4℃下至少等于一个月,并且更特别地在45℃下至少等于一个月具有均匀外观。
据另一个特定方面,所述用途在于稳定化妆品、皮肤药物或药物局部组合物中的固体颗粒。
这些要悬浮的固体颗粒可以具有各种规则或不规则的几何形状,并且可以是珍珠、珠粒、棒、薄片、小叶或多面体的形式。这些固体颗粒的特征在于表观平均直径为1μm与5mm之间,更特别地为在10μm与1mm之间。
在化妆品、皮肤药物或药物局部组合物中,可用如先前定义的油包水型乳液(E)的悬浮和稳定的固体颗粒是云母、氧化铁、氧化钛、氧化锌、氧化铝、滑石、二氧化硅、高岭土、粘土、氮化硼、碳酸钙、碳酸镁、碳酸氢镁、无机有色颜料、聚酰胺(如尼龙6)、聚乙烯、聚丙烯、聚苯乙烯、聚酯、丙烯酸或甲基丙烯酸聚合物(如聚甲基丙烯酸甲酯)、聚四氟乙烯、结晶或微晶蜡、多孔球、硫化硒、吡硫鎓锌、淀粉、藻酸盐、植物纤维、丝瓜络颗粒和海绵颗粒。
本发明的主题还是一种局部化妆品组合物(F),其包含基于100%其总质量,在0.1质量%与10质量%之间的如上定义的油包水型乳液(E),以及还有一种局部药物组合物(G),其特征在于该局部药物组合物包含,作为增稠剂,基于100%其总质量,在0.1质量%与10质量%之间的如权利要求1至8之一项所述的油包水型乳液(E)。
在所述组合物(F)和(G)的定义中使用的术语“局部”意指它们通过施用于皮肤、头发、头皮或粘膜使用,无论它是在化妆品、皮肤化妆品、皮肤药物或药物制剂的情况下的直接施用,还是例如在呈纺织品或纸擦拭物形式的身体护理产品或旨在与皮肤或粘膜接触的卫生产品的情况下的间接施用。
所述组合物(F)和(G)总体上是处于水溶液或水-醇溶液或水-二醇溶液的形式,处于悬浮液、乳液、微乳液或纳米乳液的形式,无论它具有油包水、水包油、水包油包水还是油包水包油的类型。
如前定义的所述组合物(F)和(G)可以被包装在瓶中、泵瓶类型的装置中、气溶胶装置中(以加压形式)、配备有镂空壁(如格栅)的装置中或配备有球涂抹器(滚抹的)的装置中。
一般而言,所述组合物(F)和(G)还包含通常在用于局部使用的配制品(特别是化妆品、皮肤化妆品、药物或皮肤药物配制品)领域中使用的赋形剂和/或活性成分,如增稠和/或胶凝表面活性剂、稳定剂、成膜化合物、水溶助剂、增塑剂、乳化剂和助乳化剂、遮光剂、珠光剂、加脂剂(overfatting agent)、多价螯合剂、螯合剂、抗氧化剂、香料、防腐剂、调理剂、旨在用于漂白皮肤和身体毛发的漂白剂、旨在用于皮肤或头发上提供治疗作用的活性成分、防晒剂、矿物填料或颜料、提供视觉效果或旨在用于封装活性剂的颗粒、去角质颗粒和质地剂。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的发泡和/或洗涤剂表面活性剂的实例,可以提及阴离子、阳离子、两性或非离子的发泡和/或洗涤剂表面活性剂。
在可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的发泡和/或洗涤剂阴离子表面活性剂之中,可以提及烷基醚硫酸盐、烷基硫酸盐、烷基酰胺基醚硫酸盐、烷基芳基聚醚硫酸盐、单甘油酯硫酸盐、α-烯烃磺酸盐、链烷烃磺酸盐、烷基磷酸盐、烷基醚磷酸盐、烷基磺酸盐、烷基酰胺磺酸盐、烷基芳基磺酸盐、烷基羧酸盐、烷基磺基琥珀酸盐、烷基醚磺基琥珀酸盐、烷基酰胺磺基琥珀酸盐、烷基磺基乙酸盐、烷基肌氨酸盐、酰基羟乙基磺酸盐、N-酰基牛磺酸盐、酰基乳酸盐、N-酰基氨基酸衍生物、N-酰基肽衍生物、N-酰基蛋白衍生物或脂肪酸的N-酰基衍生物的碱金属盐、碱土金属盐、铵盐、胺盐、氨基醇盐。
在可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的发泡和/或洗涤剂两性表面活性剂之中,可以提及烷基甜菜碱、烷基酰胺基甜菜碱、磺基甜菜碱、烷基酰胺基烷基磺基甜菜碱、咪唑啉衍生物、磷酸酯甜菜碱、两性聚乙酸盐和两性丙酸酯。
在可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的发泡和/或洗涤剂阳离子表面活性剂之中,可以特别提及季铵衍生物。
在可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的发泡和/或洗涤剂非离子表面活性剂之中,更特别地可以提及包括直链或支链的、饱和或不饱和的脂族基团(并且包括从8至16个碳原子)的烷基聚糖苷,例如辛基聚葡萄糖苷、癸基聚葡萄糖苷、十一烷基聚葡萄糖苷、十二烷基聚葡萄糖苷、十四烷基聚葡萄糖苷、十六烷基聚葡萄糖苷、或1,12-十二烷二基聚葡萄糖苷;乙氧基化的氢化蓖麻油衍生物,例如在INCI名称PEG-40氢化蓖麻油下出售的产品;聚山梨醇酯,例如聚山梨醇酯20、聚山梨醇酯40、聚山梨醇酯60、聚山梨醇酯70、聚山梨醇酯80和聚山梨醇酯85;椰仁酰胺;N-烷基胺。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的增稠和/或胶凝表面活性剂的实例,任选地可以提及烷氧基化的烷基聚糖苷脂肪酯,例如乙氧基化的甲基聚葡萄糖苷酯,如分别以名称GlutamateTM LT和GlutamateTM DOE120销售的PEG 120甲基葡萄糖三油酸酯和PEG 120甲基葡萄糖二油酸酯;烷氧基化的脂肪酯,如在名称CrothixTM DS53下出售的PEG 150季戊四醇四硬脂酸酯,在名称AntilTM 141下出售的PEG55丙二醇油酸酯;脂肪链聚亚烷基二醇氨基甲酸酯,例如在名称ElfacosTM T211下出售的PPG-14月桂醇聚醚异佛尔基二氨基甲酸酯,在名称ElfacosTM GT2125下出售的PPG-14棕榈油醇聚醚60己基二氨基甲酸酯。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的增稠和/或胶凝剂的实例,可以提及AMPS和丙烯酸烷基酯的共聚物,其中碳基链包括在4与30个之间的碳原子,并且更特别地在10与30个之间的碳原子;至少一种带有游离的、部分盐化或完全盐化的强酸官能团单体与至少一种中性单体和至少一种式(XVII)的单体的直链、支链或交联的的三元共聚物:
CH2=C(R′3)-C(=O)-[CH2-CH2-O]n-R′4 (XVII)
其中R′3表示氢原子或甲基,R′4表示包含从8至30个碳原子的直链或支链的烷基,并且n表示大于或等于1且小于或等于50的数。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的增稠和/或胶凝剂的实例,可以提及仅由单糖组成的多糖,如葡聚糖或葡萄糖均聚物、葡甘露聚糖葡聚糖、木葡聚糖、半乳甘露聚糖,其中主D-甘露糖链上的D-半乳糖单元的取代度(DS)是在0与1之间、并且更特别地在1与0.25之间,如来源于肉桂胶(DS=1/5)、刺槐豆胶(DS=1/4)、塔拉胶(DS=1/3)、瓜尔豆胶(DS=1/2)或葫芦巴胶(DS=1)的半乳甘露聚糖。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的增稠和/或胶凝剂的实例,可以提及由单糖衍生物组成的多糖,如硫酸化的半乳聚糖并且更具体地角叉菜胶和琼脂,乌龙糖(uronans)并且更具体地褐藻胶、海藻酸盐和果胶,单糖和糖醛酸的杂聚物,并且更具体地黄原胶、结冷胶、阿拉伯胶渗出液和刺梧桐树胶渗出液、和葡糖胺聚糖。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的增稠和/或胶凝剂的实例,可以提及纤维素,纤维素衍生物如甲基纤维素、乙基纤维素、羟丙基纤维素,硅酸盐,淀粉,亲水淀粉衍生物和聚氨酯。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的稳定剂的实例,可以提及单晶蜡,并且更特别地是地蜡,无机盐如氯化钠或氯化镁,以及硅酮聚合物如聚硅氧烷聚烷基聚醚共聚物。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的溶剂的实例,可以提及水,有机溶剂,例如甘油、双甘油、甘油低聚物、乙二醇、丙二醇、丁二醇、1,3-丙二醇、1,2-丙二醇、己二醇、二甘醇、木糖醇、赤藓醇、山梨糖醇、水溶性醇(如乙醇、异丙醇或丁醇),以及水和所述有机溶剂的混合物。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的泉水或矿泉水的实例,可以提及具有至少300mg/I的矿化的泉水或矿泉水,特别是雅漾(Avene)水、维泰尔(Vittel)水、维希盆地(Vichy basin)水、依泉(Uriage)水、理肤泉(La Roche Posay)水、拉布尔布尔(La Bourboule)水、安亘湖(Enghien-les-Bains)水、圣泉薇莱班(Saint-Gervais-les-Bains)水、内里莱班(Néris-les-Bains)水、阿勒瓦尔莱班(Allevard-les-Bains)水、迪涅(Digne)水、迈济耶尔(Maizieres)水、Neyrac-les-bains水、隆勒索涅(Lonsle Saunier)水、罗什福尔(Rochefort)水、Saint Christau水、Fumades水和Tercis-les-bains水。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的水溶助剂的实例,可以提及二甲苯磺酸盐、枯烯磺酸盐、己基聚葡糖苷、2-乙基己基聚葡糖苷和正庚基聚葡糖苷。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的乳化表面活性剂的实例,可以提及非离子表面活性剂、阴离子表面活性剂和阳离子表面活性剂。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的乳化非离子表面活性剂的实例,可以提及山梨糖醇的脂肪酸酯,例如以名称MontaneTM 40、MontaneTM60、MontaneTM 70、MontaneTM 80和MontaneTM 85销售的产品;包含硬脂酸甘油酯和用在5mol与150mol之间的环氧乙烷乙氧基化的硬脂酸的组合物,例如包含用135mol环氧乙烷乙氧基化的硬脂酸和硬脂酸甘油酯的组合物(在名称SimulsolTM 165下出售);脱水甘露醇酯、乙氧基化的脱水甘露醇酯;蔗糖酯;甲基葡萄糖酯;包含直链或支链、饱和或不饱和的脂族基团并且包含从14至36个碳原子的烷基聚糖苷,例如十四烷基聚葡糖苷、十六烷基聚葡糖苷、十八烷基聚葡糖苷、十六烷基聚木糖苷、十八烷基聚木糖苷、二十烷基聚葡糖苷、二十二烷基(dodecosyl)聚葡糖苷、(2-辛基十二烷基)聚木糖苷、(12-羟基硬脂基)聚葡糖苷;包含从14至36个碳原子的直链或支链、饱和或不饱和脂肪醇和如前描述的烷基聚糖苷的组合物,例如以名称MontanovTM 68、MontanovTM 14、MontanovTM 82、MontanovTM 202、MontanovTM S、MontanovTM WO18、MontanovTM L、FluidanovTM 20X和EasynovTM销售的组合物。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的阴离子表面活性剂的实例,可以提及甘油硬脂酸酯柠檬酸酯、鲸蜡硬脂醇硫酸酯、肥皂如硬脂酸钠或硬脂酸三乙醇铵、以及盐化的氨基酸的N-酰基衍生物(例如硬脂酰谷氨酸盐)。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的乳化阳离子表面活性剂的实例,可以提及氧化胺、季铵盐-82和在专利申请WO 96/00719中描述的表面活性剂,并且主要是其中脂肪链包含至少16个碳原子的那些。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的遮光剂和/或珠光剂的实例,可以提及棕榈酸钠、硬脂酸钠、羟基硬脂酸钠、棕榈酸镁、硬脂酸镁、羟基硬脂酸镁、乙二醇单硬脂酸酯、乙二醇二硬脂酸酯、聚乙二醇单硬脂酸酯、聚乙二醇二硬脂酸酯、以及包括从12至22个碳原子的脂肪醇。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的质地剂的实例,可以提及氨基酸的N-酰基衍生物,例如在名称AminohopeTM LL下出售的月桂酰赖氨酸、在名称DryfloTM下出售的辛烯基淀粉琥珀酸盐、在名称MontanovTM 14下出售的肉豆蔻基聚葡萄糖苷、纤维素纤维、棉纤维、壳聚糖纤维、滑石、绢云母和云母。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的除臭剂的实例,可以提及碱金属硅酸盐,锌盐如硫酸锌、葡萄糖酸锌、氯化锌或乳酸锌;季铵盐,例如十六烷基三甲基铵盐、或十六烷基吡啶盐;甘油衍生物,例如甘油癸酸酯、甘油辛酸酯和聚甘油癸酸酯;1,2-癸二醇、1,3-丙二醇;水杨酸;碳酸氢钠;环糊精;金属沸石;TriclosanTM;水合溴化铝,水合氯化铝,氯化铝,硫酸铝,水合氯化铝锆,水合三氯化铝锆,水合四氯化铝锆,水合五氯化铝锆,水合八氯化铝锆,硫酸铝,乳酸钠铝,水合氯化铝和二醇的络合物,例如水合氯化铝和丙二醇的络合物,水合二氯化铝和丙二醇的络合物,倍半氯化羟基铝和丙二醇的络合物,水合氯化铝和聚乙二醇的络合物,水合二氯化铝和聚乙二醇的络合物,以及倍半氯化羟基铝和聚乙二醇的络合物。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的油的实例,可以提及矿物油,例如液体石蜡、液体凡士林、异链烷烃或白色矿物油;动物来源的油例如角鲨烯或角鲨烷;植物油,如角鲨烷、甜杏仁油、椰仁油、蓖麻油、霍霍巴油、橄榄油、菜籽油、花生油、向日葵油、小麦胚芽油、玉米胚芽油、大豆油、棉籽油、苜蓿油、罂粟油、南瓜油、月见草油、小米油、大麦油、黑麦油、红花油、桐树油、西番莲油、榛子油、棕榈油、乳木果油、杏仁油、横经席叶油、大蒜芥油、鳄梨油、金盏花油,衍生自花或蔬菜的油,乙氧基化的植物油;合成油,例如脂肪酸酯,如肉豆蔻酸丁酯,肉豆蔻酸丙酯,肉豆蔻酸异丙酯,肉豆蔻酸鲸蜡酯,棕榈酸异丙酯,棕榈酸辛酯,硬脂酸丁酯,硬脂酸十六烷基酯,硬脂酸异丙酯,硬脂酸辛酯,硬脂酸异鲸蜡酯,油酸十二烷基酯,月桂酸己酯,二辛酸丙二醇酯,衍生自羊毛脂酸的酯类(如羊毛脂酸异丙酯、羊毛脂酸异鲸蜡酯),脂肪酸单甘油酯、二甘油酯和三甘油酯(例如三庚酸甘油酯),苯甲酸烷基酯,氢化油,聚(α-烯烃),聚烯烃(如聚(异丁烷)),合成的异烷烃(例如异十六烷、异十二烷),全氟化油;硅酮油,例如二甲基聚硅氧烷、甲基苯基聚硅氧烷、用胺改性的硅酮、用脂肪酸改性的硅酮、用醇改性的硅酮、用醇和脂肪酸改性的硅酮、用聚醚基团改性的硅酮、环氧基改性的硅酮、用氟基团改性的硅酮、环状硅酮以及用烷基改性的硅酮。在本专利申请中,术语“油”是指水不溶性的并且在25℃的温度下具有液体外观的化合物和/或化合物的混合物。
作为可以与如前定义的所述组合物(F)和(G)中的油包水型乳液(E)组合的蜡的实例,可以提及蜂蜡、巴西棕榈蜡、小烛树蜡、小冠巴西棕蜡、日本蜡、软木纤维蜡、甘蔗蜡、石蜡、褐煤蜡、微晶蜡、羊毛脂蜡;地蜡;聚乙烯蜡;硅酮蜡;植物蜡;在室温下是固体的脂肪醇和脂肪酸;在室温下是固体的甘油酯。在本专利申请中,术语“蜡”是指水不溶性的并且在大于或等于45℃的温度下具有固体外观的化合物和/或化合物的混合物。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的有效成分的实例,可以提及维生素及其衍生物,特别是其酯,如视黄醇(维生素A)和其酯(例如棕榈酸视黄酯)、抗坏血酸(维生素C)和其酯、抗坏血酸的糖衍生物(如抗坏血酸葡萄糖苷)、生育酚(维生素E)和其酯(如生育酚乙酸酯)、维生素B3或B10(烟酰胺及其衍生物);显示美白或脱色素作用的化合物,如在名称SepiwhiteTM MSH、SepicalmTM VG下出售的ω-十一碳烯酰基(undecelynoyl)苯丙氨酸、ω-十一碳烯酰基苯丙氨酸的甘油单酯和/或二酯、ω-十一碳烯酰基二肽、熊果苷、曲酸以及氢醌;显示镇静作用的化合物,特别是SepicalmTM S、尿囊素和甜没药醇;抗炎剂;显示保湿作用的化合物,如尿素、羟基脲、甘油、聚甘油、甘油葡萄糖苷、二甘油葡萄糖苷、聚甘油葡萄糖苷、木糖醇葡萄糖苷;富含多酚的植物提取物,如葡萄提取物、松树提取物、葡萄酒(wine)提取物以及橄榄提取物;显示减肥或解脂作用的化合物,如咖啡因或其衍生物、AdiposlimTM、AdipolessTM、岩藻黄质;N-酰基蛋白质;N-酰基肽如MatrixylTM;N-酰基氨基酸;N-酰基部分蛋白质水解产物;氨基酸;肽;总蛋白质水解产物;大豆提取物,例如RaffermineTM;小麦提取物,例如TensineTM或GliadineTM;植物提取物,如富含丹宁酸的植物提取物、富含异黄酮的植物提取物或富含萜的植物提取物;淡水或海水藻类提取物;海洋植物提取物;海洋提取物,通常例如珊瑚;精华蜡(essential wax);细菌提取物;神经酰胺;磷脂;显示抗菌作用或纯化作用的化合物,如LipacideTM C8G、LipacideTMUG、SepicontrolTM A5;OctopiroxTM或SensivaTMSC50;显示激励或刺激特性的化合物,如PhysiogenylTM、泛醇以及其衍生物如SepicapTM MP;抗老化活性剂,如SepiliftTM DPHP、LipacideTM PVB、SepivinolTM、SepivitalTM、ManolivaTM、Phyto-AgeTM、TimecodeTM;SurvicodeTM;抗光老化活性剂;用于保护真皮-表皮接合处的完整性的剂;用于提高细胞外基质的组分的合成的剂,如胶原、弹性蛋白和糖胺聚糖;在化学细胞通信上顺利地作用的活性剂,如细胞因子,或在物理细胞通信上顺利地作用的活性剂,如整合素;在皮肤上产生“发热”感觉的活性剂,如皮肤毛细血管循环的活化剂(如烟酸衍生物)或在皮肤上产生“清凉”感觉的产品(如薄荷醇及其衍生物);改善皮肤毛细血管循环的活性剂,例如静脉紧张剂;排水活性剂;减充血药活性剂,如银杏、常春藤、马栗树、竹、假叶树(Ruscus)、假叶树(butcher’s broom)、积雪草、岩藻、迷迭香或柳树的提取物;皮肤晒黑或致黑的试剂,例如二羟基丙酮(DHA)、赤藓酮糖、内消旋酒石醛、戊二醛、甘油醛、阿脲(alloxan)、茚三酮、植物提取物,例如紫檀属和巴非豆(Baphia)属的红木提取物,例如檀香紫檀(Pteropcarpussantalinus)、非洲紫檀(Pterocarpus osun)、绍氏紫檀(Pterocarpus soyauxii)、刺猬紫檀(Pterocarpus erinaceus)、印度紫檀(Pterocarpus indicus)或非洲小叶紫檀(Baphianitida),如在欧洲专利申请EP 0 971 683中描述的那些;以其促进和/或加速人体皮肤的晒黑或致黑的作用和/或以其着色人体皮肤的作用已知的试剂,例如类胡萝卜素(并且更特别地β-胡萝卜素和γ-胡萝卜素)),由Provital公司以商标名“胡萝卜油(Carros oil)”(INCI名称:胡萝卜(Daucus Carota),向日葵葵花子油)出售的产品,其含有类胡萝卜素、维生素E和维生素K;酪氨酸和/或其衍生物,以其结合对紫外线辐射的暴露而加速人体皮肤晒黑的作用而知名,例如由Provital公司以商标名SunTan AcceleratorTM销售的产品,其含有酪氨酸和核黄素(维生素B),由Zymo Line公司以商标名Zymo TanComplex销售的酪氨酸和酪氨酸酶复合物,由Mibelle公司以商标名MelanoBronzeTM(INCI名称:乙酰酪氨酸、圣洁莓(monk′s pepper)提取物(Vitex agnus-castus))销售的产品,其含有乙酰酪氨酸,由Unipex公司以商标名Unipertan VEG-24/242/2002(INCI名称:丁二醇和乙酰酪氨酸以及水解植物蛋白和三磷酸腺苷)销售的产品,由Sederma公司以商标名Try-ExcellTM(INCI名称:油酰酪氨酸和丝瓜(Luffa cylindrica)(种子)油和油酸)销售的产品,其含有西葫芦种子(marrow seed)(或菜瓜子油(loofah oil))的提取物,由Alban Muller公司以商标名ActibronzeTM(INCI名称:水解小麦蛋白和乙酰酪氨酸和葡萄糖酸铜)销售的产品,由Synerga公司以商标名TyrostanTM(INCI名称:己酰酪氨酸钾)销售的产品,由Synerga公司以商标名Tyrosinol(INCI名称:脱水山梨醇异硬脂酸酯,油酸甘油酯,己酰酪氨酸)销售的产品,由Alban Muller公司以商标名InstaBronzeTM(INCI名称:二羟基丙酮和乙酰酪氨酸和葡萄糖酸铜)销售的产品,由Exymol公司以商标名Tyrosilane(INCI名称:甲基硅烷醇和乙酰酪氨酸)销售的产品;以其激活黑素生成的作用而知名的肽,例如由Infinitec Activos公司以商标名Bronzing SF肽粉(INCI名称:葡聚糖和八肽-5)销售的产品,以商标名Melitane(INCI名称:甘油和水和葡聚糖和乙酰六肽-1)销售的产品,其包含以α-MSH激动剂作用而知名的乙酰六肽-1,由Lipotec公司以商标名Melatimes SolutionsTM(INCI名称:丁二醇,棕榈酰三肽-40)销售的产品,糖和糖衍生物,例如由Provital公司以商标名TanositolTM(INCI名称:肌醇)销售的产品,由CODIF International公司以商标名ThalitanTM(或PhycosaccharideTM AG)销售的产品(INCI名称:水和水解藻酸盐(掌状海带(Laminariadigitata))和硫酸镁和硫酸锰),其含有海洋来源的低聚糖(与镁和锰离子螯合的古洛糖醛酸和甘露糖醛酸),由Alban Muller公司以商标名MelactivaTM(INCI名称:麦芽糊精,刺毛黧豆(Mucuna pruriens)种子提取物)销售的产品,富含类黄酮的化合物,例如由Silab公司以商标名Biotanning(INCI名称:水解甜橙(citrus Aurantium dulcis)果实提取物)销售的产品,其已知富含柠檬类黄酮(橙皮苷(hesperidin)类);旨在用于处理头发和/或体毛的试剂,例如用于保护毛囊黑色素细胞的试剂,旨在保护所述黑色素细胞免受是所述黑色素细胞的衰老和/或凋亡的原因的细胞毒素剂,如多巴色酶互变异构酶活性的模拟,选自在EP 1515 688 A2号下公开的欧洲专利申请中所描述的那些,合成的SOD模拟分子,例如锰络合物,抗氧化剂化合物,例如环糊精衍生物,衍生自抗坏血酸、赖氨酸或精氨酸吡咯烷酮羧酸盐的含二氧化硅的化合物,肉桂酸和维生素C的单酯和二酯的组合,以及更一般地是在EP 1515 688 A2号下公开的欧洲专利申请中提到的那些。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的抗氧化剂的实例,可以提及EDTA及其盐、柠檬酸、酒石酸、草酸、BHA(丁基羟基苯甲醚)、BHT(丁基羟基甲苯)、生育酚衍生物如生育酚乙酸酯、抗氧化剂化合物的混合物(如由阿克苏诺贝尔公司(AkzoNobel)在INCI名称下出售的Dissolvine GL 47S:谷氨酸二乙酸四钠)。
作为可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的防晒剂的实例,可以提及在修订的化妆品指令76/768/EEC附件VII中出现的那些。
在可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的有机防晒剂中,可以提及苯甲酸衍生物的家族,例如对-氨基苯甲酸(PABA),特别是PABA的单甘油酯、N,N-丙氧基PABA的乙基酯、N,N-二乙氧基PABA的乙基酯、N,N-二甲基PABA的乙基酯、N,N-二甲基PABA的甲基酯和N,N-二甲基PABA的丁基酯;邻氨基苯甲酸衍生物的家族,例如3,3,5-三甲基环己基(homomenthyl)-N-乙酰基邻氨基苯甲酸酯;水杨酸衍生物的家族,例如水杨酸戊酯、水杨酸高孟酯(homomenthyl salicylate)、水杨酸乙基己酯、水杨酸苯酯、水杨酸苄酯和水杨酸对-异丙醇苯基酯;肉桂酸衍生物的家族,例如肉桂酸乙基己酯、肉桂酸乙基-4-异丙酯、肉桂酸甲基2,5-二异丙酯、肉桂酸对-甲氧基丙酯、肉桂酸对-甲氧基异丙酯、肉桂酸对-甲氧基异戊酯、肉桂酸对-甲氧基辛酯(肉桂酸对-甲氧基2-乙基己酯)、肉桂酸对-甲氧基-2-乙氧基乙酯、肉桂酸对-甲氧基环己酯、肉桂酸乙基-α-氰基-β-苯酯、肉桂酸2-乙基己基-α-氰基-β-苯酯或肉桂酸甘油基二-对-甲氧基单-2-乙基己酰酯;二苯甲酮衍生物的家族,例如2,4-二羟基二苯甲酮、2,2′-二羟基-4-甲氧基二苯甲酮、2,2′,4,4′-四羟基二苯甲酮、2-羟基-4-甲氧基二苯甲酮、2-羟基-4-甲氧基-4′-甲基二苯甲酮、2-羟基-4-甲氧基二苯甲酮-5-磺酸酯、4-苯基二苯甲酮、2-乙基己基4′-苯基二苯甲酮-2-5-羧酸酯、2-羟基-4-正辛氧基二苯甲酮、4-羟基-3-羧基二苯甲酮;3-(4′-甲基亚苄基)-d,l-樟脑、3-(亚苄基)-d,l-樟脑、樟脑苯扎铵甲基硫酸酯;尿刊酸、尿刊酸乙酯;磺酸衍生物的家族,例如2-苯基苯并咪唑-5-磺酸及其盐;三嗪衍生物的家族,例如羟基苯基三嗪、(乙基己氧基羟基苯基)(4-甲氧基苯基)三嗪、2,4,6-三苯胺基(对羰基(carbo)-2′-乙基己基-1′-氧基)-1,3,5-三嗪、4,4-((6-(((1,1-二甲基乙基)氨基)羰基)苯基)氨基)-1,3,5-三嗪-2,4-二基二亚氨基)双-(2-乙基己基)苯甲酸酯、2-苯基-5-甲基苯并噁唑、2,2′-羟基-5-甲基苯基苯并三唑、2-(2′-羟基-5′-叔辛基苯基)苯并三唑、2-(2′-羟基-5′-甲基苯基)苯并三唑;二苯并氮卓(dibenzazepine);二对甲氧苯甲酰基甲烷、4-甲氧基-4″-叔丁基苯甲酰基甲烷;5-(3,3-二甲基-2-降冰片烯)-3-戊-2-酮;二苯基丙烯酸酯衍生物的家族,例如2-乙基己基-2-氰基-3,3-二苯基-2-丙烯酸酯、2-氰基-3,3-二苯基-2-丙烯酸乙酯;聚硅氧烷的家族,例如亚苄基硅氧烷丙二酸酯。
在可以与如前定义的所述组合物(F)和(G)中油包水型乳液(E)组合的无机防晒剂(也称为“矿物防晒剂”)之中,可以提及氧化钛,氧化锌,氧化铈,氧化锆,黄色、红色或黑色的氧化铁,以及氧化铬。这些矿物遮蔽剂可以进行或可以不进行微粉化,可以经历或可以不经历表面处理并且可以任选地呈水性或油性预分散体的形式。
以下实例阐明本发明,然而不限制本发明。
IA-基于烷基聚葡糖苷和甘油的组合物(Ce2A)的制备
通过在90℃搅拌下依次以希望的比例引入前述每种脂肪醇,制备72.5kg(即8.5摩尔当量)的混合物(M1),其包含基于100%其质量,30.2质量%的1-辛醇、38.4质量%的1-癸醇、7.4质量%的1-十二烷醇、8.9质量%的1-十四醇、5.1质量%的1-十六醇和10.0质量%的1-十八醇。
将混合物(M1)在90℃下匀化30分钟,然后向其中添加8.7kg(即1摩尔当量)葡萄糖,并且然后添加80g的98%硫酸。然后将反应介质放在从90x 102Pa(90毫巴)至45x 102Pa(45毫巴)的部分真空下,并在从100℃至105℃的温度下保持5小时,同时除去形成的水。然后将反应介质冷却至80℃,并通过添加76g的40%氢氧化钠来中和。滤出产物以除去未反应的葡萄糖。
获得了72.0kg的基质,该基质包含所形成的葡糖苷物种以及还有化学计量过量的未反应的脂肪醇。然后通过在薄膜蒸发器上处理除去由此获得的混合物中存在的残留醇。
然后将36.6kg如此中和的反应介质在从3x 102Pa(3毫巴)至5x 10Pa(5毫巴)的减压与240℃的壁温下引入薄膜蒸发器中,以蒸馏掉大部分残留醇并获得4.5kg的浓缩物,在搅拌下向其中逐渐添加4.5kg的甘油,从而获得9.0kg的预期组合物(Ce2a)。
IB-基于烷基聚葡糖苷和二甘油的组合物(Ce2B)的制备
重复上述实例1的程序,甘油用二甘油代替,其质量比例使得它们使能够获得组合物(Ce2B),其包含基于100%其质量50质量%的二甘油。
IC-基于烷基聚葡糖苷和聚甘油-6的组合物(Ce2C)的制备
重复上述实例1的程序,甘油用聚甘油-6(以商标名Polyglycerol-6TM从Spiga公司销售)代替,其质量比例使得它们使能够获得组合物(Ce2C),其包含基于100%其质量50质量%的聚甘油-6。
IT-基于烷基聚葡糖苷和1,3-丙二醇的组合物(Ce2T)的制备
重复上述实例1的程序,甘油用1,3-丙二醇(以商标名ZemeaTM丙二醇从杜邦Tate&Lyle公司销售)代替,其质量比例使得它们使能够获得组合物(Ce2T),其包含基于100%其质量22质量%的1,3-丙二醇。
II-2-甲基-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸钠盐和部分盐化的丙烯酸的交联的共聚物的自可逆反相胶乳的制备和评估
通过在搅拌下向烧杯中顺序倾倒277g的去离子水、73.1g的冰丙烯酸、308g的2-甲基[(1-氧代-2-丙烯基)氨基]-1-丙磺酸、141g的含48质量%氢氧化钠的水溶液、0.45g的含40质量%二亚乙基三胺五乙酸钠的商用水溶液和0.128g亚甲基双(丙烯酰胺)制备水相。然后将此水相的pH调节至5.4,并将溶液用去离子水补足至682g的重量。
独立地,通过混合220g的异十六烷、15g的MontaneTM 80、10g的MontaneTM 70和0.2g的偶氮双(异丁腈)(AIBN)来制备有机相。
然后将制备的水相逐渐添加到油相中并且然后使用IKA公司出售的Ultra-Turrax转子-定子进行分散。
将获得的乳液转移到反应器中,用氮气鼓泡除去氧气,并冷却至约5℃-6℃。在连续搅拌下,将5cm3的含有0.42质量%枯烯氢过氧化物在异十六烷中的溶液添加到乳液中,随后在60分钟内以0.5cm3/min的流速逐渐引入含有2.5质量%的偏亚硫酸氢钠的水溶液,以引发聚合反应。将介质的温度升高至稳定阶段。然后将反应介质在85℃加热1小时并且然后将组件冷却至约35℃,以获得标记为(M2)的混合物。
将先前获得的混合物(M2)分成几个部分,向其中添加如上所述的不同表面活性剂组合物((Ce2A))、(Ce2B)、(Ce2C)和(Ce2T),以及还有聚山梨酯80(78质量%的活性物质)(以商标名MontanoxTM 80(S2)销售)、以及癸酰基/辛酰基聚葡糖苷水溶液(60质量%的活性物质)(以商标名SimulsolTMSL8销售)(标记为组合物S′2),其质量比例例如以下表1所示。
由这些混合物产生的自可逆反相胶乳分别表示为(E1)、(E2)、(E3)、(EGl)、(EC2)和(EC3)并且通过观察它们在25℃下的外观、它们在25℃下的粘度、在制备包含2质量%的自可逆反相胶乳的水凝胶的过程中的反相速度、包含2质量%的自可逆反相胶乳的这种水凝胶的粘度以及在0.1质量%氯化钠存在下包含3质量%的自可逆反相胶乳的这种水凝胶的粘度进行评估。
评估自可逆反相胶乳的反相时间的方法包括将制备800g水凝胶所需量的水倒入1升的烧杯中。将连接到电机上的TurbotestTM机械搅拌器叶轮放在烧杯的底部。以200rpm的速度开始搅拌并在搅拌下将所需量的待评估的自可逆反相胶乳引入烧杯中。逐渐增加搅拌,以在整个增稠阶段中维持烧杯中涡旋的高度相同,直到获得光滑、均匀的凝胶。自可逆反相胶乳的反相时间对应于开始添加测试自可逆反相胶乳与生产无结块的光滑凝胶之间经过的时间。所获得的结果于以下表1中给出。
表1
*nm:未测量的
表1(续)
根据本发明的不含烷氧基化衍生物的自可逆反相胶乳(E1)、(E2)和(E3),使得可以获得光滑的凝胶,其反相时间少于10分钟,具有优异的增稠特性。此外,它们的特征在于,特别是与自可逆反相胶乳(ES′2)相比,在盐的存在下,含有3质量%的凝胶的粘度下降更小。
III-2-甲基-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸钠盐均聚物的自可逆反相胶乳的制备和评估
通过在搅拌下向烧杯中顺序倾倒220g的去离子水、343.5g的2-甲基[(1-氧代-2-丙烯基)氨基]-1-丙磺酸、138.1g含48质量%氢氧化钠的水溶液、0.18g的含40质量%二亚乙基三胺五乙酸钠的商业溶液和0.140g的亚甲基双(丙烯酰胺)制备水相。然后将此水相的pH调节至3.5,并将溶液用去离子水补足至707g的重量。
独立地,通过混合220g的异十六烷、22g的MontaneTM 80VG和0.2g的AIBN来制备有机相。
然后将制备的水相逐渐添加到油相中并且然后使用IKA公司出售的Ultra-Turrax转子-定子进行分散。
将获得的乳液转移到反应器中,用氮气鼓泡除去氧气,并冷却至约5℃-6℃。在连续搅拌下,将5cm3的含有0.42质量%枯烯氢过氧化物在异十六烷中的溶液添加到乳液中,随后在60分钟内以0.5cm3/min的流速逐渐引入含有2.5质量%的偏亚硫酸氢钠的水溶液,以引发聚合反应。将介质的温度升高至稳定阶段。将反应介质在此温度下保持1小时30分钟并且然后将组件冷却至约35℃,以获得标记为(M3)的混合物。
将先前获得的混合物(M3)分成不同部分,向其中添加不同的表面活性剂组合物(Ce2A)、(S2)和(S′2),其质量比例如以下表2所示,以获得自可逆反相胶乳,分别表示为(E4)、(EC4)和(EC5)。按照前面的第二部分对它们进行评估。所获得的结果于以下表2中给出。
表2
根据本发明的不含烷氧基化并且更特别地乙氧基化的衍生物的自可逆反相胶乳(E4)使得可以获得光滑的凝胶,其反相时间少于10分钟,具有优异的增稠特性。
IV-2-甲基-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸钠盐和(2-羟乙基)丙烯酸酯的交联的共聚物的反相胶乳的制备和评估
通过在搅拌下向烧杯中顺序倾倒20.4g的(2-羟乙基)丙烯酸酯、660g的含55质量%2-甲基[(1-氧代-2-丙烯基)氨基]-1-丙磺酸钠的商业水溶液、0.45g的含40质量%二亚乙基三胺五乙酸钠的商业水溶液和0.123g亚甲基双(丙烯酰胺)制备水相。然后通过添加0.55g的2-甲基[(1-氧代-2-丙烯基)氨基]-1-丙磺酸将此水相的pH调节至4.0。
独立地,通过混合265g的角鲨烷、17.76g的MontaneTM 80 VG、9.24g的MontaneTM81 VG和0.2g的偶氮双(异丁腈)(AIBN)来制备有机相。
然后将制备的水相逐渐添加到油相中并且然后使用IKA公司出售的Ultra-Turrax转子-定子进行分散。
将获得的乳液转移到反应器中,用氮气鼓泡除去氧气,并冷却至约5℃-6℃。在连续搅拌下,将10cm3的含有0.28质量%枯烯氢过氧化物在角鲨烷中的溶液添加到乳液中,随后在60分钟内以0.5cm3/min的流速逐渐引入含有2.5质量%的偏亚硫酸氢钠的水溶液,以引发聚合反应,同时使得反应温度升高至75℃。然后将反应介质在该温度下保持约60分钟,此时间之后将所获得的混合物冷却至约35℃。将组件冷却至约35℃(M4)的温度。
将先前获得的混合物(M4)分成不同部分,向其中添加不同的表面活性剂组合物(Ce2A)、(S2)和(S′2),其质量比例如以下表3所示。
由这些混合物产生的自可逆反相胶乳分别记为(E5)、(EC6)和(EC7)。按照前面的第二部分对它们进行评估。所获得的结果于以下表3中给出:
表3
根据本发明的不含烷氧基化并且更特别地乙氧基化的衍生物的自可逆反相胶乳(E5)使得可以获得光滑的凝胶,其反相时间少于10分钟,具有优异的增稠特性。
V-2-甲基-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸钠盐和丙烯酰胺的交联的共聚物的反相胶乳的制备
通过在搅拌下向烧杯中顺序倾倒80g的去离子水、253.8g的含50质量%丙烯酰胺的商业水溶液、246.7g的2-甲基[(1-氧代-2-丙烯基)氨基]-1-丙磺酸、95.96g的含48质量%氢氧化钠的水溶液、0.45g的含40重量%二亚乙基三胺五乙酸钠的商业溶液和0.115g亚甲基双(丙烯酰胺)制备水相。然后将此水相的pH调节至5.5,并将溶液用去离子水补足至682g的重量。
独立地,通过混合220g的异十六烷、21g的MontaneTM 80 VG和0.2g的偶氮双(异丁腈)(AIBN)来制备有机相。
然后将制备的水相逐渐添加到油相中并且然后使用IKA公司出售的Ultra-Turrax转子-定子进行分散。
将获得的乳液转移到反应器中,用氮气鼓泡除去氧气,并冷却至约5℃-6℃。在连续搅拌下,将5cm3的含有0.28质量%枯烯氢过氧化物在异十六烷中的溶液添加到乳液中,随后在60分钟内以0.5cm3/min的流速逐渐引入含有2.5质量%的偏亚硫酸氢钠的水溶液,以引发聚合反应,同时使得反应温度升高至75℃。然后将反应介质在该温度下保持约60分钟,此时间之后将所获得的混合物冷却至约35℃。将组件冷却至约35℃(M5)的温度。
如以下表4所示,将先前获得的混合物(M5)分成不同部分,向其中添加不同质量比例的表面活性剂组合物(Ce2A)。
由这些混合物产生的自可逆反相胶乳分别记为(EC8)和(EC9)。按照前面的第二部分对它们进行评估。所获得的结果于以下表4中给出:
表4
不含烷氧基化的衍生物的自可逆反相胶乳(Ec8)和(Ec9)不能使能获得具有小于10分钟的反相时间并且具有均匀外观的光滑凝胶。
VI:说明性化妆品配制品
在以下配制品中,百分数表示为基于100%的配制品质量的质量百分数。
VIa-护理霜
配方
VIb-防晒乳
配方
程序
在60℃在A中乳化B,然后在约60℃添加C,然后在约30℃添加D,并在必要时调节pH。
VIc-身体乳
配方
VId-含甜杏仁油的卸妆乳液
配方
VIe:针对油性皮肤的保湿霜
配方
VIf-卸妆乳
VIg-防晒乳
VIh-人工晒黑乳液
VIi-护理霜
VIj-防晒霜
VIk-防晒霜和自晒黑凝胶
在实例中使用的商业产品的定义如下:
MicropearlTM M 100是具有非常柔软的手感和消光作用的超细粉末
SepicideTM CI,咪唑烷基脲,是市售防腐剂
SimulsolTM 165是自乳化甘油硬脂酸酯
SepicideTM HB(苯氧乙醇、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯和对羟基苯甲酸丁酯的混合物)是防腐剂
ParsolTM MCX是对甲氧基肉桂酸辛酯
LanolTM 37 T是甘油三庚酸酯
SolagumTM L是角叉菜胶
EusolexTM 4360是防晒霜
DeepalineTM PVB是酰化的小麦蛋白水解产物
PrimolTM 352是矿物油
PecosilTM PS 100是聚二甲基硅氧烷PEG-7
MontanovTM 68(INCI名称:十六醇(和)十六烷基葡糖苷)是乳化剂
MontanovTM L(INCI名称:C14-22醇(和)C12-20烷基葡糖苷)是乳化剂
MontanovTM202(INCI名称:花生醇和山萮醇和花生基)是乳化剂
Claims (11)
1.一种油包水型乳液(E),包含基于100%其质量:
a)-从10质量%至80质量%衍生自以下项的聚合的交联的聚合物(P),基于100mol%:
(a1)-大于或等于30mol%且小于或等于100mol%比例的衍生自以下项的单体单元:2- 甲基-2-[(1-氢代-2-丙烯基)氢基]-1-丙磺酸,其是以钠盐或铵盐形式部分盐化或完全盐 化的;以及
(a2)-任选地大于0mol%且小于或等于70mol%比例的衍生自至少一种单体的单体单元:该单体选自由以下组成的组的元素:丙烯酸、甲基丙烯酸、衣康酸、马来酸、3-甲基-3-[(1-氧代-2-丙烯基)氨基]丁酸、所述单体的羧酸官能团是以部分盐化或完全盐化的酸形式,和/或选自由以下组成的组的元素:(2-羟乙基)丙烯酸酯、(2,3-二羟丙基)丙烯酸酯、(2-羟乙基)甲基丙烯酸酯、(2,3-二羟丙基)甲基丙烯酸酯或乙烯基吡咯烷酮;
(a3)-大于0mol%且小于或等于1mol%比例的衍生自至少一种二烯键或多烯键交联单体(AR)的单体单元;应当理解,这些单体单元(a1)、(a2)和(a3)的摩尔比例之和是等于100%;
b)-从5质量%至50质量%的由至少一种油(H)构成的脂肪相;以及
c)-从1质量%至50质量%的水;
d)-从0.5质量%至10质量%的油包水型的乳化体系(S1);以及
e)-从2质量%至10质量%的水包油型的乳化体系(S2),该水包油型的乳化体系包含基于100%其质量,至少50质量%的组合物(Ce),该组合物包含基于100%其质量:
e1)-大于或等于20质量%且小于或等于80质量%比例的式(I)的稀释剂:
HO-[CH2-CH(OH)-CH2-O-]n-H(I),
其中n是大于或等于1且小于或等于6的整数,或所述稀释剂的混合物,
e2)-大于或等于20质量%且小于或等于80质量%的比例的组合物(Ce2),该组合物包含基于100%其质量:
e2α)-大于0质量%且小于或等于4质量%的比例的至少一种式(II)的醇:
CmH2m+1-OH (II),
其中m是大于或等于8且小于或等于18的偶数整数;
e2β)-大于或等于96质量%且小于100质量%比例的组合物(C2β),包含:
e2β2)-大于或等于60质量%且小于或等于90质量%比例的组合物(C2β2),该组合物包含基于100%其质量:
e2β21)-大于或等于5质量%且小于或等于20质量%比例的由式(III)表示的组合物(C21):
R21-O-(G21)r-H (III),
其中R21表示正十二烷基,G21表示还原糖残基,并且r表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C21)由式(III1)、(III2)、(III3)、(III4)和(III5)的化合物的混合物组成:
R21-O-(G21)1-H (III1),
R21-O-(G21)2-H (III2),
R21-O-(G21)3-H (III3),
R21-O-(G21)4-H (III4),
R21-O-(G21)5-H (III5),
所述式(III1)、(III2)、(III3)、(III4)和(III5)的化合物的摩尔比例分别等于a1、a2、a3、a4和a5,使得a1+a2+a3+a4+a5之和等于1,并且使得a1+2a2+3a3+4a4+5a5之和等于r;
e2β22)-大于或等于10质量%且小于或等于20质量%比例的由式(IV)表示的组合物(C22):
R22-O-(G22)s-H (IV),
其中R22表示正十四烷基,G22表示还原糖残基,并且s表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C22)由式(IV1)、(IV2)、(IV3)、(IV4)和(IV5)的化合物的混合物组成:
R22-O-(G22)1-H (IV1),
R22-O-(G22)2-H (IV2),
R22-O-(G22)3-H (IV3),
R22-O-(G22)4-H (IV4),
R22-O-(G22)5-H (IV5),
所述式(IV1)、(IV2)、(IV3)、(IV4)和(IV5)的化合物的摩尔比例分别等于b1、b2、b3、b4和b5,使得b1+b2+b3+b4+b5之和等于1,并且使得b1+2b2+3b3+4b4+5b5之和等于s;
e2β23)-大于或等于25质量%且小于或等于40质量%比例的由式(V)表示的组合物(C23):
R23-O-(G23)t-H (V),
其中R23表示正辛基,G23表示还原糖残基,并且t表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C23)由式(V1)、(V2)、(V3)、(V4)和(V5)的化合物的混合物组成:
R23-O-(G23)1-H (V1),
R23-O-(G23)2-H (V2),
R23-O-(G23)3-H (V3),
R23-O-(G23)4-H (V4),
R23-O-(G23)5-H (V5),
所述式(V1)、(V2)、(V3)、(V4)和(V5)的化合物的摩尔比例分别等于c1、c2、c3、c4和c5,使得c1+c2+c3+c4+c5之和等于1,并且使得c1+2c2+3c3+4c4+5c5之和等于t;
e2β24)-大于或等于30质量%且小于或等于55质量%的质量比例的由式(VI)表示的组合物(C24):
R24-O-(G24)u-H (VI),
其中R24表示正癸基,G24表示还原糖残基,并且u表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C24)由式(VI1)、(VI2)、(VI3)、(VI4)和(VI5)的化合物的混合物组成:
R24-O-(G24)1-H (VI1),
R24-O-(G24)2-H (VI2),
R24-O-(G24)3-H (VI3),
R24-O-(G24)4-H (VI4),
R24-O-(G24)5-H (VI5),
所述式(VI1)、(VI2)、(VI3)、(VI4)和(VI5)的化合物的摩尔比例分别等于d1、d2、d3、d4和d5,使得d1+d2+d3+d4+d5之和等于1,并且使得d1+2d2+3d3+4d4+5d5之和等于u;应当理解,组合物(C21)、(C22)、(C23)和(C24)的质量比例之和等于100%;
e2β3)-大于或等于10质量%且小于或等于40质量%比例的组合物(C2β3),包含基于100%其质量:
e2β31)-大于或等于30质量%且小于或等于50质量%比例的由式(VII)表示的组合物(C31):
R31-O-(G31)x-H (VII)
其中R31表示正十六烷基,G31表示还原糖残基,并且x表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C31)由式(VII1)、(VII2)、(VII3)、(VII4)和(VII5)的化合物的混合物组成:
R31-O-(G31)1-H (VII1),
R31-O-(G31)2-H (VII2),
R31-O-(G31)3-H (VII3),
R31-O-(G31)4-H (VII4),
R31-O-(G31)5-H (VII5),
所述式(VII1)、(VII2)、(VII3)、(VII4)和(VII5)的化合物的摩尔比例分别等于a’1、a’2、a’3、a’4和a’5,使得a’1+a’2+a’3+a’4+a’5之和等于1,并且使得a’1+2a’2+3a’3+4a’4+5a’5之和等于x;
e2β32)-大于或等于50质量%且小于或等于70质量%比例的由式(VIII)表示的组合物(C32):
R32-O-(G32)y-H (VIII),
其中R32表示正十八烷基,G32表示还原糖残基,并且y表示大于或等于1.05且小于或等于5.00的十进制数,所述组合物(C32)由式(VIII1)、(VIII2)、(VIII3)、(VIII4)和(VIII5)的化合物的混合物组成:
R32-O-(G32)1-H (VIII1),
R32-O-(G32)2-H (VIII2),
R32-O-(G32)3-H (VIII3),
R32-O-(G32)4-H (VIII4),
R32-O-(G32)5-H (VIII5),
所述式(VIII1)、(VIII2)、(VIII3)、(VIII4)和(VIII5)的化合物的摩尔比例分别等于b’1、b’2、b’3、b’4和b’5,使得b’1+b’2+b’3+b’4+b’5之和等于1,并且使得b’1+2b’2+3b’3+4b’4+5b’5之和等于y;应当理解,组合物(C31)和(C32)的质量比例之和等于100%;并且应当理解,化合物(a)、(b)、(c)、(d)和(e)的质量比例之和是等于100%。
2.如权利要求1所述的油包水型乳液(E),其中,该聚合物(P)是选自:
-以钠盐或铵盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸与三烯丙基胺和/或亚甲基双(丙烯酰胺)交联的均聚物;
-以钠盐或铵盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸和(2-羟乙基)丙烯酸酯与三烯丙基胺和/或亚甲基双(丙烯酰胺)交联的共聚物;
-以钠盐或铵盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸和丙烯酸与三烯丙基胺和/或亚甲基双(丙烯酰胺)交联的共聚物;
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和(2-羟乙基)丙烯酸酯(δ)以在30/70与90/10之间(γ)/(δ)摩尔比的交联的共聚物;
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和(2-羟乙基)丙烯酸酯(δ)以在40/60与90/10之间(γ)/(δ)摩尔比的交联的共聚物;
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和以钠盐形式部分或完全盐化的丙烯酸(ε),以大于或等于30/70且小于或等于90/10(γ)/(ε)摩尔比的交联的共聚物;以及
-以钠盐形式部分或完全盐化的2-甲基-2-[(1-氧代-2-丙烯基)氨基]-1-丙磺酸(γ)和以钠盐形式部分或完全盐化的丙烯酸(ε),以大于或等于40/60且小于或等于90/10(γ)/(ε)摩尔比的交联的共聚物。
3.如权利要求1和2中任一项所述的油包水型乳液(E),其特征在于,该式(I)的稀释剂是甘油。
4.如权利要求1至3中任一项所述的油包水型乳液(E),其特征在于,在式(III)、(IV)、(V)和(VI)中,所述还原糖残基G21、G22、G23和G24是相同的并且表示葡萄糖残基。
5.如权利要求1至4中任一项所述的油包水型乳液(E),其特征在于,在式(III)、(IV)、(V)和(VI)中,r、s、t和u分别彼此独立地表示大于或等于1.05且小于或等于2.5的十进制数。
6.如权利要求1至5中任一项所述的油包水型乳液(E),其特征在于,在式(VII)和(VIII)中,所述还原糖残基G31和G32是相同的并且表示葡萄糖残基。
7.如权利要求1至6中任一项所述的油包水型乳液(E),其特征在于,在式(VII)和(VIII)中,x和y分别表示大于或等于1.05且小于或等于2.5的十进制数。
8.如权利要求1至7中任一项所述的油包水型乳液(E),其特征在于,质量比:
△=组合物(C2β2)的质量/组合物(C2β3)的质量,
大于或等于1且小于或等于10。
9.如权利要求1至8之一项所述的油包水型乳液(E),作为增稠剂和/或乳化剂和/或稳定剂用于化妆品局部组合物的用途。
10.一种局部化妆品组合物(F),其特征在于,该局部化妆品组合物包含,作为增稠剂,基于100%其总质量,在0.1质量%与10质量%之间的如权利要求1至8之一项所述的油包水型乳液(E)。
11.一种局部药物组合物(G),其特征在于,该局部药物组合物包含,作为增稠剂,基于100%其总质量,在0.1质量%与10质量%之间的如权利要求1至8之一项所述的油包水型乳液(E)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1760987A FR3073854B1 (fr) | 2017-11-21 | 2017-11-21 | Latex inverse auto-inversible, comprenant comme agent inverseur des alkylpolyglycosides, son utilisation comme agent epaississant, et compositions cosmetiques en comprenant |
FR1760987 | 2017-11-21 | ||
PCT/FR2018/052887 WO2019102116A1 (fr) | 2017-11-21 | 2018-11-16 | Latex inverse auto-inversible, comprenant comme agent inverseur des alkylpolyglycosides, son utilisation comme agent épaississant, et compositions cosmétiques en comprenant |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111356431A true CN111356431A (zh) | 2020-06-30 |
Family
ID=61599323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880074172.XA Pending CN111356431A (zh) | 2017-11-21 | 2018-11-16 | 包含烷基聚糖苷作为反相剂自可逆反相胶乳,其作为增稠剂的用途,以及包含其的化妆品组合物 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP3713539A1 (zh) |
JP (1) | JP2021504322A (zh) |
CN (1) | CN111356431A (zh) |
FR (1) | FR3073854B1 (zh) |
WO (1) | WO2019102116A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112169713A (zh) * | 2020-09-09 | 2021-01-05 | 江南大学 | 一种n-烷基乳糖胺表面活性剂小分子醇凝胶及其制备方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3795134B1 (fr) * | 2019-09-19 | 2023-05-10 | Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC | Compositions parfumantes, stables et possédant de bonnes propriétés de pulvérisation |
FR3104165B1 (fr) * | 2019-12-09 | 2021-12-17 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Latex inverse pour composition cosmétique comprenant un agent séquestrant particulier et un polyélectrolyte combinant fonction acide forte et fonction neutre |
KR102453976B1 (ko) * | 2021-03-30 | 2022-10-14 | 주식회사 비제이바이오켐 | 다당류 유도체 및 이의 제조 방법 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2794124A1 (fr) * | 1999-05-28 | 2000-12-01 | Seppic Sa | Nouveau latex inverse auto inversible, procede de preparation et utilisation en cosmetique |
CN102076324A (zh) * | 2008-06-27 | 2011-05-25 | 化工产品开发公司Seppic | 不含氧亚乙基衍生物的新型反相胶乳以及包含它们的化妆品的、皮肤用化妆品的、皮肤药物的或药物的组合物 |
CN102325520A (zh) * | 2009-02-19 | 2012-01-18 | 化工产品开发公司Seppic | 粉状的烷基聚糖苷乳化组合物、其用于制备化妆品乳液的用途及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2721607B1 (fr) | 1994-06-28 | 1996-10-31 | Seppic Sa | Nouveaux dérivés d'ammoniums quaternaires, leur procédé de préparation et leur utilisation comme agents de surface. |
FR2761595B1 (fr) | 1997-04-04 | 1999-09-17 | Oreal | Compositions comprenant des santalines, santarubines pour la coloration artificielle de la peau et utilisations |
FR2794034B1 (fr) | 1999-05-28 | 2001-08-03 | Seppic Sa | Utilisation d'alkylpolyglycosides comme inverseur d'emulsions de polymeres, procede d'inversion d'emulsions, latex inverse auto inversible et leurs utilisations industrielles |
FR2808447B1 (fr) | 2000-05-05 | 2004-12-03 | Seppic Sa | Latex inverses sur huiles blanches minerales, squalane ou polyisobutene hydrogene, compositions cosmetiques, dermocosmetiques, dermopharmaceutiques ou pharmaceutiques en comportant |
FR2808446B1 (fr) | 2000-05-05 | 2004-12-03 | Seppic Sa | Latex inverses sur huiles blanches minerales, squalane, polyisobutene hydrogene, isohexadecane ou isododecane, compositions cosmetiques ou pharmaceutiques en comportant |
FR2810883B1 (fr) | 2000-06-28 | 2006-07-28 | Seppic Sa | Nouveaux latex inverses autoinversibles sur des esters d'acides gras, compositions cosmetiques, dermocosmetiques, dermopharmaceutiques ou pharmaceutiques en comportant |
EP1515688B1 (fr) | 2002-06-11 | 2013-07-24 | L'Oréal | Utilisation d'un complexe salen-manganèse comme agent protecteur des mélanocytes du follicule pileux et applications cosmétiques |
-
2017
- 2017-11-21 FR FR1760987A patent/FR3073854B1/fr active Active
-
2018
- 2018-11-16 WO PCT/FR2018/052887 patent/WO2019102116A1/fr unknown
- 2018-11-16 JP JP2020527953A patent/JP2021504322A/ja active Pending
- 2018-11-16 EP EP18826410.5A patent/EP3713539A1/fr not_active Withdrawn
- 2018-11-16 CN CN201880074172.XA patent/CN111356431A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2794124A1 (fr) * | 1999-05-28 | 2000-12-01 | Seppic Sa | Nouveau latex inverse auto inversible, procede de preparation et utilisation en cosmetique |
CN102076324A (zh) * | 2008-06-27 | 2011-05-25 | 化工产品开发公司Seppic | 不含氧亚乙基衍生物的新型反相胶乳以及包含它们的化妆品的、皮肤用化妆品的、皮肤药物的或药物的组合物 |
CN102325520A (zh) * | 2009-02-19 | 2012-01-18 | 化工产品开发公司Seppic | 粉状的烷基聚糖苷乳化组合物、其用于制备化妆品乳液的用途及其制备方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112169713A (zh) * | 2020-09-09 | 2021-01-05 | 江南大学 | 一种n-烷基乳糖胺表面活性剂小分子醇凝胶及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
FR3073854A1 (fr) | 2019-05-24 |
EP3713539A1 (fr) | 2020-09-30 |
WO2019102116A1 (fr) | 2019-05-31 |
FR3073854B1 (fr) | 2019-11-01 |
JP2021504322A (ja) | 2021-02-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10111825B2 (en) | Oil-in-water emulsions enriched with salt which are highly viscous and stable over time | |
JP6757740B2 (ja) | フォーム形態で提供される新規の化粧品エマルション、それを得る方法、およびその美容的使用 | |
JP7394063B2 (ja) | 反転剤として、ポリグリセロールエステル系統の界面活性剤種を含む増粘性の自己可逆性逆ラテックス、及びそれを含有する組成物 | |
US20160015609A1 (en) | Novel water-in-oil emulsions with a high content of aqueous phase and of liquid consistency, which are stable on storage | |
CN111356431A (zh) | 包含烷基聚糖苷作为反相剂自可逆反相胶乳,其作为增稠剂的用途,以及包含其的化妆品组合物 | |
JP7320525B2 (ja) | ポリグリセロールエステルを含む自己可逆性逆ラテックス、増粘剤としてのそれの使用、及びそれを含む化粧品組成物 | |
US20140350125A1 (en) | Novel oil-in-water emulsions enriched with salt, which are stabilized using natural gums, highly viscous, and stable over time | |
US20150335567A1 (en) | Novel oil-in-water emulsions rich in salts, having high viscosity and stable over time | |
JP6370378B2 (ja) | 新規な粉末ポリマー、その作製方法及び増粘剤としてのその使用 | |
US11426341B2 (en) | Alkyl polyrhamnosides, process for the preparation thereof, and cosmetic and/or pharmaceutical composition comprising same | |
CN114846078B (zh) | 组合有作为螯合剂的谷氨酸n,n-二乙酸的四钠盐和包含amps和丙烯酰胺的聚电解质的用于化妆品组合物的反相胶乳 | |
JP2023505297A (ja) | 特定の金属イオン封鎖剤と弱酸官能基を有する高分子電解質とを組み合わせた化粧品組成物用の逆ラテックス | |
JP2023504634A (ja) | 特定のキレート剤並びに強酸官能基及び弱酸官能基を合わせる高分子電解質を含む化粧用組成物のための逆ラテックス | |
JP2023504635A (ja) | キレート剤としてのeddsと、amps及びアクリルアミドを含む高分子電解質とを組み合わせた、化粧品組成物用の逆ラテックス | |
KR20210069660A (ko) | 빗질이 개선되도록 모발을 처리하기 위한 유중수 에멀젼 형태의 화장 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200630 |