CN111346049A - Preparation method of skin and mucous membrane disinfectant - Google Patents
Preparation method of skin and mucous membrane disinfectant Download PDFInfo
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- CN111346049A CN111346049A CN201811568886.4A CN201811568886A CN111346049A CN 111346049 A CN111346049 A CN 111346049A CN 201811568886 A CN201811568886 A CN 201811568886A CN 111346049 A CN111346049 A CN 111346049A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention belongs to the technical field of daily disinfection products, and particularly relates to a preparation method of a skin mucosa disinfectant. The present invention provides a better method of preparing a sterilized product than the prior art formulations; the test of an authoritative department shows that the microbial preparation has an inactivation effect on intestinal pathogenic bacteria such as escherichia coli and the like, purulent bacteria such as staphylococcus aureus, pseudomonas aeruginosa and the like, and pathogenic fungi such as candida albicans and the like. Not only the disinfection is effectual, does not have the irritability to skin mucosa moreover, safe and reliable, practical convenient is applicable to the disinfection of skin, mucosa, if: sterilizing the hands before surgery, the skin of the operation part, the skin of the injection part and the sanitary hands; oral mucosa, wound, burn, and vaginal skin mucosa. The skin mucosa disinfectant provided by the invention has the advantages of reasonable formula, reliable manufacturing process, excellent performance, convenience in use and wide market prospect.
Description
Technical Field
The invention belongs to the technical field of daily disinfection products, and particularly relates to a preparation method of a skin mucosa disinfectant.
Background
With the improvement of living standard of people and the special attention to health, more and more people pay attention to disease prevention and disinfection, and disinfection products are used in families and workplaces. There are many types of products for disinfecting air, water, environment, and objects, and not many products that are good for disinfecting skin mucosa directly for personal hygiene and personal care.
The current disinfectant widely used in surgical hand disinfection and debridement disinfection in the international medical community is chlorhexidine alcohol disinfectant, and clinical effects prove that the disinfectant has strong bactericidal performance. Is a disinfection component which is generally applied to skin and mucosa disinfectants in all countries in the world at present and is widely used internationally. Skin disinfection liquids produced by many international companies mainly comprise 0.5% chlorhexidine alcoholic preparations, but the products have high irritation, can be only used for disinfection of normal skin and cannot be used for disinfection of damaged skin and mucosa; the povidone iodine aqueous solution is widely produced and sold at home and abroad, but due to limited sterilization effect and higher use concentration, products containing 0.75 percent and 1 percent of effective iodine are commonly used at home and abroad, and the stock solution is mainly directly smeared for disinfection. Before the product is used, the skin is cleaned by a detergent, and the product can be uniformly coated after sebum is removed, so that the product is complex to use; the existing chlorhexidine-iodine complex aqueous solution has the appearance of products at home and abroad, but the aqueous solution has the defects of more foam, greasiness, poor stability and general sterilization effect.
The ideal skin mucosa disinfectant has the following basic requirements: 1. broad spectrum sterilization; 2. the use concentration is low; 3. the action speed is high; 4. the property is stable; 5. is easily soluble in water; 6. can be used at low temperature; 7. is not easily influenced by organic matters, acid, alkali and other physical and chemical factors; 8. no corrosion to articles; 9. colorless, tasteless, and easy to remove residual medicine after disinfection; 10. no toxicity or low toxicity; 11. the use is not dangerous; 12. low price, convenient transportation, large-scale supply and the like. In addition, as a skin mucosa disinfectant, the disinfectant should not irritate, damage or toxicity to skin mucosa, and is beneficial to protection, repair and nourishing of skin mucosa. When the disinfectant is used for disinfecting incisions and wounds, the healing of the wounds is not hindered; the operation is simple, convenient and fast, and high-efficiency performance is required to avoid repeated smearing. Because the skin mucosa disinfection time is very short in clinical practical work, the disinfectant with high sterilization speed is also needed, so that the rapid operation is convenient, the valuable time is won for rescuing patients, and the infection can be avoided. Therefore, it is very urgent to provide a disinfection product which is efficient, safe, convenient, fast, practical and easy to operate. The prior art or products in the market at present do not meet this demand well. In view of the above, we developed and developed the skin and mucous membrane disinfectant, which can be used for wiping, spraying, smearing or soaking.
Disclosure of Invention
The invention aims to provide a preparation method of a skin mucosa disinfectant which has strong sterilization effect, good sterilization effect, no irritation to skin mucosa, safety, reliability, practicability and convenience, and is suitable for human skin, hands, oral cavity and vagina.
The technical scheme adopted by the invention for realizing the purpose is as follows:
the skin mucosa disinfectant is prepared by compounding the following components in percentage by weight:
the preparation method of the skin mucosa disinfectant provided by the invention comprises the following steps:
1 weighing the raw materials according to the weight;
2 adding glycerol and aloe gel juice into 10% purified water under stirring, and stirring to obtain solution A;
3 adding allantoin into purified water of about 10% under stirring, and stirring to obtain solution B;
4 adding sodium hyaluronate into purified water of about 10% while stirring, and stirring uniformly to obtain solution C;
5 adding polyhexamethylene biguanide into purified water of about 10% while stirring, and stirring uniformly to obtain solution D;
6, adding chlorhexidine gluconate into purified water with the concentration of about 10% under stirring, and stirring to obtain solution E;
7 mixing the solution A, the solution B and the solution C, and uniformly mixing to obtain solution F;
8, mixing the solution D and the solution E uniformly to obtain a solution G;
9 mixing the solution F and the solution G, and uniformly mixing to obtain solution H;
10 adding purified water to about 90% in the H liquid while stirring;
11 adding the food essence while stirring;
12 adding purified water to 100%;
13 continuously stirring the mixture for 15 to 30 minutes by using a homogenizer until the mixture is completely and uniformly mixed;
14, placing the liquid into a temporary storage tank for standing for later use;
15, inspecting, and subpackaging qualified persons;
16 can be made into disinfectant products such as spray, liquid, aerosol, wet towel, and cotton ball.
The solution of the skin and mucous membrane disinfectant is transparent to yellowish transparent liquid without sediment and delamination.
The stability test of the skin mucosa disinfectant solution proves that: the effective period is more than or equal to 24 months, and the reduction rate of the effective content is less than or equal to 10 percent after the product is stored for 3 months at 37 ℃.
The detection of the mucocutaneous disinfectant by an authority proves that various technical indexes all meet the requirements of national technical standards.
The skin and mucous membrane disinfectant has the function of inactivating intestinal pathogenic bacteria such as escherichia coli and the like, purulent bacteria such as staphylococcus aureus, pseudomonas aeruginosa and the like, and pathogenic fungi such as candida albicans and the like. Is suitable for disinfecting skin and mucosa, such as: sterilizing the hands before surgery, the skin of the operation part, the skin of the injection part and the sanitary hands; oral mucosa, wound, burn, and vaginal skin mucosa.
The skin and mucous membrane disinfectant is safe, non-toxic and non-irritating, and has the effects of sterilizing, relieving itching, removing odor, cleaning, moistening skin and nursing.
The skin mucosa disinfectant provided by the invention has the advantages of reasonable formula, reliable manufacturing process, excellent performance, convenience in use and wide market prospect.
Detailed Description
[ example 1 ]
The formula of the skin and mucous membrane disinfectant is prepared by compounding the following components in percentage by weight:
the preparation method comprises the following steps:
1 weighing the raw materials according to the weight;
2 adding glycerol and aloe gel juice into 10% purified water under stirring, and stirring to obtain solution A;
3 adding allantoin into purified water of about 10% under stirring, and stirring to obtain solution B;
4 adding sodium hyaluronate into purified water of about 10% while stirring, and stirring uniformly to obtain solution C;
5 adding polyhexamethylene biguanide into purified water of about 10% while stirring, and stirring uniformly to obtain solution D;
6, adding chlorhexidine gluconate into purified water with the concentration of about 10% under stirring, and stirring to obtain solution E;
7 mixing the solution A, the solution B and the solution C, and uniformly mixing to obtain solution F;
8, mixing the solution D and the solution E uniformly to obtain a solution G;
9 mixing the solution F and the solution G, and uniformly mixing to obtain solution H;
10 adding purified water to about 90% in the H liquid while stirring;
11 adding the food essence while stirring;
12 adding purified water to 100%;
13 continuously stirring the mixture for 15 to 30 minutes by using a homogenizer until the mixture is completely and uniformly mixed;
14, placing the liquid into a temporary storage tank for standing for later use;
15, inspecting, and subpackaging qualified persons;
16 making into spray disinfectant product.
Claims (5)
1. A process for preparing disinfecting liquid for skin and mucosa includes such steps as proportionally mixing polyhexamethylene biguanide, chlorhexidine gluconate, propanetriol, aloe gel juice, allantoin, sodium hyaluronate, food essence and purified water, preparing liquid, aerosol, spray, wet towel, or cotton ball.
2. The preparation method of claim 1, wherein the skin mucosa disinfectant is prepared by compounding the following components in percentage by weight: 0.1-0.5 of polyhexamethylene biguanide; chlorhexidine gluconate 0.2-0.5; 0.6-6 parts of glycerol; aloe vera gel juice 0.05-0.5; allantoin 0.03-0.3; 0.01-0.1 of sodium hyaluronate; 0.001-0.01% of food essence; and (4) purifying the balance of water.
3. The preparation method according to claim 1, wherein (1) the raw materials are weighed according to the weight; (2) adding glycerol and aloe gel juice into 10% purified water under stirring, and stirring to obtain solution A; (3) adding allantoin into purified water (10% or so), and stirring to obtain solution B; (4) adding sodium hyaluronate into purified water of about 10% under stirring, and stirring to obtain solution C; (5) adding polyhexamethylene biguanide into purified water of about 10% under stirring, and stirring to obtain solution D; (6) adding chlorhexidine gluconate into purified water of about 10% under stirring, and stirring to obtain solution E; (7) mixing the solution A, the solution B and the solution C, and uniformly mixing to obtain solution F; (8) mixing the solution D and the solution E, and uniformly mixing to obtain solution G; (9) mixing the solution F and the solution G, and uniformly mixing to obtain solution H; (10) adding purified water into the H liquid to about 90% while stirring; (11) adding food essence while stirring; (12) accurately adding purified water to 100%; (13) continuously stirring for 15-30 minutes by using a homogenizer until the mixture is completely and uniformly mixed; (14) placing the liquid into a temporary storage tank for standing for later use; (15) inspecting, and subpackaging qualified persons; (16) can be made into disinfectant products such as liquid, spray, aerosol, wet towel, and cotton ball.
4. The polyhexamethylene biguanide and like starting materials according to claim 1 in food or pharmaceutical grade.
5. The percentage of claim 1 is weight percent (w/w) or volume weight percent (w/v) because the error between the two is negligible.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811568886.4A CN111346049A (en) | 2018-12-21 | 2018-12-21 | Preparation method of skin and mucous membrane disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811568886.4A CN111346049A (en) | 2018-12-21 | 2018-12-21 | Preparation method of skin and mucous membrane disinfectant |
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| Publication Number | Publication Date |
|---|---|
| CN111346049A true CN111346049A (en) | 2020-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811568886.4A Pending CN111346049A (en) | 2018-12-21 | 2018-12-21 | Preparation method of skin and mucous membrane disinfectant |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773241A (en) * | 2020-07-21 | 2020-10-16 | 贵州威克斯医疗科技有限公司 | Composition containing PHMB for preventing and relieving diaper eczema |
-
2018
- 2018-12-21 CN CN201811568886.4A patent/CN111346049A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773241A (en) * | 2020-07-21 | 2020-10-16 | 贵州威克斯医疗科技有限公司 | Composition containing PHMB for preventing and relieving diaper eczema |
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Application publication date: 20200630 |