CN101940577A - Compound-type aqueous multiple-effect environmentally-friendly bactericide as well as preparation method and applications thereof - Google Patents
Compound-type aqueous multiple-effect environmentally-friendly bactericide as well as preparation method and applications thereof Download PDFInfo
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- CN101940577A CN101940577A CN 201010292526 CN201010292526A CN101940577A CN 101940577 A CN101940577 A CN 101940577A CN 201010292526 CN201010292526 CN 201010292526 CN 201010292526 A CN201010292526 A CN 201010292526A CN 101940577 A CN101940577 A CN 101940577A
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Abstract
The invention relates to a compound-type aqueous multiple-effect environmentally-friendly bactericide as well as a preparation method and applications thereof. The bactericide is mainly composed of the following components in parts by weight: 5-15 parts of chlorhexidine acetate, 1-15 parts of polyethylene glycol octyl phenyl ether, 0.1-3 parts of sulfacetamide sodium and 52-94.4 parts of purified water or distilled water. The preparation method comprises the steps of mixing and heating. The compound-type aqueous multiple-effect environmentally-friendly bactericide is applied in human bodies, livestock skins, mucosas and substance surfaces for sterilizing, and has the effects of diminishing inflammation, converging, relieving pain, relieving itch and removing peculiar smell. Compared with the prior art, the bactericide of the invention has the advantages of more sterilization categories, high sterilization rate, simple manufacturing process, low cost, wide application range, more application objects, accurate curative effect position and reliable safe use accordance.
Description
Technical field
The present invention relates to a kind of compound type aqueous multiple-effect, environmentally-friendly antibacterial and manufacture method and purposes.
Background technology
In the past, the antibacterial that medical prevention is used mostly is single agent, and defective is more, in recent years, chemical bactericide composite oneself become an important research direction.For example, the scientist around the advantage that how to keep the agent of chlorhexidine acetate list, overcomes it and is insoluble in water under study for action, only is dissolved in shortcomings such as ethanol, promotes its more effect, reduces toxicity, has carried out various composite researchs and invention.
Chinese invention patent CN200510090828.1 discloses a kind of " manufacture method of disinfection sanitizer, disinfection sanitizer and uses thereof ", this disinfection sanitizer existence sterilization kind is few, sterilizing rate is low, manufacturing process is complicated, cost is high, range of application is narrow, application is few, defectives such as the curative effect location is indeterminate, and the safe handling foundation is unreliable.For this reason, invent that a kind of sterilization kind is many, sterilizing rate is high, manufacturing process is simple, cost is low, applied range, application are many, and the curative effect location is clear and definite, and safe handling be very much necessity according to antibacterial reliably.
Summary of the invention
The objective of the invention is to overcome that above-mentioned sterilization kind is few, sterilizing rate is low, manufacturing process is complicated, cost is high, range of application is narrow, application is few, the curative effect location is indeterminate, defectives such as the safe handling foundation is unreliable, provide that a kind of sterilization kind is many, sterilizing rate is high, manufacturing process is simple, at the bottom of the cost, applied range, application are many, and the curative effect location is clear and definite, and safe handling is according to compound type aqueous multiple-effect, environmentally-friendly antibacterial reliably.
Antibacterial of the present invention is characterized in that, mainly is made up of chlorhexidine acetate, the stupid basic ether of Polyethylene Glycol octyl group, sulphacetamide and pure water or distilled water, and above-mentioned each component shared weight portion in gross weight is respectively:
Chlorhexidine acetate: 5 ~ 15;
The stupid basic ether of Polyethylene Glycol octyl group: 0.5 ~ 30;
Sulphacetamide: 0.1 ~ 3
Pure water or distilled water: 52 ~ 94.4.
The manufacture method of this antibacterial is as follows:
A, with chlorhexidine acetate 5 ~ 15 weight portions, stupid basic ether 0.5 ~ 30 weight portion of Polyethylene Glycol octyl group, sulphacetamide 0.1 ~ 3 weight portion, pure water or distilled water 52 ~ 94.4 weight portions, mixed stir and be heated to 93 ~ 95 ℃ is cooled to room temperature;
B, with above-mentioned liquid mixture prepared dilution preparation finished fluid:
Above-mentioned liquid mixture prepared and pure water or distilled water are mixed, dilute, stir, make the content of chlorhexidine acetate in this diluent account for 0.01 ~ 0.5% of diluent gross weight, pH value is 6 ~ 7.6.This diluent is finished fluid of the present invention.
Antibacterial purposes of the present invention is characterized in that, above-mentioned antibacterial is used for the sterilization medicine of human body, domestic animal skin surface, mucosa and body surface.
Concrete application, effect and the toxicological characteristics of antibacterial provided by the invention:
A, be applied to human body, domestic animal skin, mucosa and the sterilization of thing table, the chlorhexidine acetate height was inversely proportional to the time of bactericidal action, the fastest sterilizing time of this antibacterial, can in 1 minute, kill escherichia coli, staphylococcus aureus, Staphylococcus albus, bacillus pyocyaneus, gram negative bacteria, gram positive bacteria and Candida albicans, Diplococcus gonorrhoeae, Salmonella typhimurium, have a liking for the skin bacterium, new metropolitan area virus, its sterilizing rate is 100%, bacillus subtilis black variety gemma, anthrax spore is had 100% bacteriostasis efficacy;
B, be applied to human body, domestic animal skin, germ-resistant while of mucosa, to its surface have antiinflammatory, convergence, pain relieving, antipruritic, curative effect eliminates the unusual smell, oral cavity for example: ulcer, foaming, gingivitis, tonsillitis, pharyngolaryngitis, wound gets a tooth pulled out, skin: table tinea, abscess, herpes, burning, scald, wound, knife injury, scratch where it itches, decubital ulcer, beriberi, paronychia, gynecological: inside and outside cloudy inflammation, eczema, abnormal flavour, scratch where it itches, puerpera's birth canal oral-lateral is cut, children's's umbilical cord and mosquito honeybee insect stings etc.;
C, its toxicological characteristics: nontoxic, nothing irritates, does not have corrosion and environmental protection,
1, the true border of acute oral toxicity (LD50) test is nontoxic;
2, the PCEMNR micronucleus test is negative;
3, subacute toxicity test does not produce obvious toxic-side effects to the every observation index of rat;
4, the skin stimulation test belongs to does not have irritating property;
5, the eye stimulation test belongs to does not have irritating property;
6, the vaginal mucosa stimulation test belongs to extremely gently irritating property;
7, the damaged skin stimulation test belongs to extremely gently irritating property;
8, arsenic, lead content and corrosivity all meet in the national poison and learn safety index.
The present invention compared with prior art has following advantage:
The sterilization kind is many, sterilizing rate is high, manufacturing process is simple, cost is low, and applied range, application are many, and the curative effect location is clear and definite, and safe handling is according to reliably.
The specific embodiment
Embodiment 1:
Present embodiment provides a kind of antibacterial, mainly is made up of chlorhexidine acetate, the stupid basic ether of Polyethylene Glycol octyl group, sulphacetamide and pure water or distilled water, and above-mentioned each component shared weight portion in gross weight is respectively:
Chlorhexidine acetate: 5;
The stupid basic ether of Polyethylene Glycol octyl group: 5;
Sulphacetamide: 0.1
Pure water or distilled water: 89.9.
Present embodiment provides the manufacture method of above-mentioned antibacterial:
A, with chlorhexidine acetate 5 weight portions, stupid basic ether 5 weight portions of Polyethylene Glycol octyl group, sulphacetamide 0.1 weight portion, pure water or distilled water 89.9 weight portions, mixed stir and be heated to 93 ℃ is cooled to room temperature;
B, with above-mentioned liquid mixture prepared dilution preparation finished fluid:
Above-mentioned liquid mixture prepared and pure water or distilled water are mixed, dilute, stir, make the content of chlorhexidine acetate in this diluent account for 0.05% of diluent gross weight, pH value is 6 ~ 7.6.This diluent is the finished fluid of present embodiment.Packing, warehouse-in.
Above-mentioned antibacterial is used to kill and is applied to that human body, domestic animal skin, mucosa and thing table are killed escherichia coli, staphylococcus aureus, Staphylococcus albus, bacillus pyocyaneus, gram negative bacteria, gram positive bacteria and Candida albicans, Diplococcus gonorrhoeae, Salmonella typhimurium, had a liking for the skin bacterium, new metropolitan area virus, in the sterilization medicine of the human body of bacillus subtilis black variety gemma, anthrax spore, domestic animal skin surface, mucosa and body surface.And be applied to human body, domestic animal skin, germ-resistant while of mucosa, to its surface have antiinflammatory, convergence, pain relieving, antipruritic, curative effect eliminates the unusual smell, oral cavity for example: ulcer, foaming, gingivitis, tonsillitis, pharyngolaryngitis, wound gets a tooth pulled out, skin: table tinea, abscess, herpes, burning, scald, wound, knife injury, scratch where it itches, decubital ulcer, beriberi, paronychia, gynecological: inside and outside cloudy inflammation, eczema, abnormal flavour, scratch where it itches, in the germ killing drugs at positions such as puerpera's birth canal oral-lateral is cut, children's's umbilical cord and mosquito honeybee insect stings.
Embodiment 2:
Present embodiment provides a kind of antibacterial, mainly is made up of chlorhexidine acetate, the stupid basic ether of Polyethylene Glycol octyl group, sulphacetamide and pure water or distilled water, and above-mentioned each component shared weight portion in gross weight is respectively:
Chlorhexidine acetate: 15;
The stupid basic ether of Polyethylene Glycol octyl group: 30;
Sulphacetamide: 2;
Pure water or distilled water: 53.
Present embodiment provides the manufacture method of above-mentioned antibacterial:
A, with chlorhexidine acetate 15 weight portions, stupid basic ether 30 weight portions of Polyethylene Glycol octyl group, sulphacetamide 2 weight portions, pure water or distilled water 53 weight portions, mixed stir and be heated to 95 ℃ is cooled to room temperature;
B, with above-mentioned liquid mixture prepared dilution preparation finished fluid:
Above-mentioned liquid mixture prepared and pure water or distilled water are mixed, dilute, stir, make the content of chlorhexidine acetate in this diluent account for 0.30% of diluent gross weight, pH value is 6 ~ 7.6.This diluent is the finished fluid of present embodiment.Packing, warehouse-in.
The purposes that above-mentioned antibacterial is used is with embodiment 1.
Embodiment 3:
Present embodiment provides a kind of antibacterial, mainly is made up of chlorhexidine acetate, the stupid basic ether of Polyethylene Glycol octyl group, sulphacetamide and pure water or distilled water, and above-mentioned each component shared weight portion in gross weight is respectively:
Chlorhexidine acetate: 10;
The stupid basic ether of Polyethylene Glycol octyl group: 8;
Sulphacetamide: 1.5;
Pure water or distilled water: 80.5.
Present embodiment provides the manufacture method of above-mentioned antibacterial:
A, with chlorhexidine acetate 10 weight portions, stupid basic ether 8 weight portions of Polyethylene Glycol octyl group, sulphacetamide 1.5 weight portions, pure water or distilled water 80.5 weight portions, mixed stir and be heated to 94 ℃ is cooled to room temperature;
B, with above-mentioned liquid mixture prepared dilution preparation finished fluid;
Above-mentioned liquid mixture prepared and pure water or distilled water are mixed, dilute, stir, make the content of chlorhexidine acetate in this diluent account for 0.10% of diluent gross weight, pH value is 6 ~ 7.6.This diluent is the finished fluid of present embodiment.Packing, warehouse-in.
The purposes that above-mentioned antibacterial is used is with embodiment 1.
Claims (3)
1. compound type aqueous multiple-effect, environmentally-friendly antibacterial, it is characterized in that: mainly be made up of chlorhexidine acetate, the stupid basic ether of Polyethylene Glycol octyl group, sulphacetamide and pure water or distilled water, above-mentioned each component shared weight portion in gross weight is respectively:
Chlorhexidine acetate: 5 ~ 15;
The stupid basic ether of Polyethylene Glycol octyl group: 0.5 ~ 30;
Sulphacetamide: 0.1 ~ 3;
Pure water or distilled water: 52 ~ 94.4.
2. the manufacture method of a compound type aqueous multiple-effect, environmentally-friendly antibacterial is characterized in that:
A, with chlorhexidine acetate 5 ~ 15 weight portions, stupid basic ether 0.5 ~ 30 weight portion of Polyethylene Glycol octyl group, sulphacetamide 0.1 ~ 3 weight portion, pure water or distilled water 52 ~ 94.4 weight portions, mixed stir and be heated to 93 ~ 95 ℃ is cooled to room temperature;
B, with above-mentioned liquid mixture prepared dilution preparation finished fluid: above-mentioned liquid mixture prepared and pure water or distilled water are mixed, dilute, stir, make the content of chlorhexidine acetate in this diluent account for 0.01 ~ 0.5% of diluent gross weight, pH value is that 6 ~ 7.6 these diluents are finished fluid of the present invention.
3. the purposes of a compound type aqueous multiple-effect, environmentally-friendly antibacterial, it is characterized in that: above-mentioned antibacterial is used for the sterilization medicine of human body, domestic animal skin surface, mucosa and body surface.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266314A (en) * | 2011-06-02 | 2011-12-07 | 崔秀梅 | Sterilization agent special for livestock and preparation method and application thereof |
| CN105767031A (en) * | 2016-03-02 | 2016-07-20 | 杜蕾 | General disinfectant for supply room and preparation method thereof |
| CN109966306A (en) * | 2019-03-01 | 2019-07-05 | 杭州健石药业有限公司 | Application of the Triton x-100 ointment in treatment pruitus |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711757A (en) * | 2008-10-07 | 2010-05-26 | 马辉 | High-efficiency sterilization disinfectant and preparation method thereof |
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2010
- 2010-09-27 CN CN 201010292526 patent/CN101940577A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711757A (en) * | 2008-10-07 | 2010-05-26 | 马辉 | High-efficiency sterilization disinfectant and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266314A (en) * | 2011-06-02 | 2011-12-07 | 崔秀梅 | Sterilization agent special for livestock and preparation method and application thereof |
| CN105767031A (en) * | 2016-03-02 | 2016-07-20 | 杜蕾 | General disinfectant for supply room and preparation method thereof |
| CN105767031B (en) * | 2016-03-02 | 2019-05-17 | 张静 | A kind of thimerosal and preparation method thereof that supply room is general |
| CN109966306A (en) * | 2019-03-01 | 2019-07-05 | 杭州健石药业有限公司 | Application of the Triton x-100 ointment in treatment pruitus |
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Application publication date: 20110112 |