CN111329977A - External preparation for relieving tumor pain - Google Patents

External preparation for relieving tumor pain Download PDF

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CN111329977A
CN111329977A CN202010321044.XA CN202010321044A CN111329977A CN 111329977 A CN111329977 A CN 111329977A CN 202010321044 A CN202010321044 A CN 202010321044A CN 111329977 A CN111329977 A CN 111329977A
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parts
relieving
pain
cancer
external preparation
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孙明海
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/902—Sparganiaceae (Bur-reed family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention provides an external preparation for relieving tumor pain, which is prepared by taking radix angelicae, rheum officinale, scorpion, alum, mirabilite, centipede, mitsubishi, curcuma zedoary, gecko, dandelion, purslane, phaseolus calcaratus, frankincense, myrrh, long-noded pit viper and venenum bufonis as raw materials and performing compatibility, so that the effects of the medicines generate synergy, and the effects of clearing heat and removing toxicity, activating blood and dissolving stasis, relieving swelling and pain and softening hardness and dissipating stagnation are achieved together. Clinical tests show that the medicine has a good conditioning effect on pains caused by various unknown reasons, and particularly has a good relieving effect on pains caused by gastric cancer, esophageal cancer, pancreatic cancer, gallbladder cancer, breast cancer, lung cancer, liver cancer and the like.

Description

External preparation for relieving tumor pain
Technical Field
The invention relates to a traditional Chinese medicine preparation for relieving pain, in particular to an external preparation for relieving tumor pain, and belongs to the field of traditional Chinese medicines.
Background
Cancer patients are mostly painful at an advanced stage due to disease causes or distant metastases. The management of pain symptoms is particularly important for patients with advanced cancer. Pain can be alleviated by using an analgesic appropriately according to the condition of the patient. However, the existing medicines for relieving pain are mainly western medicines, have great side effects and are not easy to take for a long time.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine preparation for relieving tumor pain, which is mainly used for relieving and conditioning pain caused by gastric cancer, pancreatic cancer, gallbladder cancer, breast cancer, lung cancer, liver cancer and the like.
The external preparation for relieving tumor pain is an external preparation prepared from radix angelicae, rheum officinale, scorpion, alum, mirabilite, centipede, mitsubishi, curcuma zedoary, gecko, dandelion, purslane, phaseolus calcaratus, frankincense, myrrh, long-noded pit viper and venenum bufonis serving as raw material medicines.
Dandelion, bitter and sweet, cold in nature, and has the main treatment functions: clearing away heat and toxic materials, promoting urination, and resolving hard mass; red bean, sweet in nature and sour in taste, enters heart and small intestine meridians. The functions and indications are as follows: induce diuresis to alleviate edema, remove toxicity and expel pus. Purslane, sour and cold, has the effects of clearing away heat and toxic materials, cooling blood and stopping bleeding. Toad venom is sweet and pungent in flavor and warm in nature; the functions are as follows: detoxify, relieve swelling, strengthen heart and alleviate pain. The invention takes dandelion, phaseolus calcaratus, purslane and toad venom as monarch drugs to clear away heat and toxic materials and reduce swelling.
Dahurian angelica root, pungent and warm. Has effects in eliminating pathogenic factors, removing dampness, promoting pus discharge, promoting granulation, promoting blood circulation, and relieving pain. Mirabilite, salty, bitter and cold in nature; the functions are as follows: purgation, relaxing bowels, moistening dryness, softening hard masses, clearing away fire and relieving swelling. Rhubarb, bitter and cold; the functions are as follows: purging heat-toxin, breaking stagnation and removing blood stasis. Alum, sour, astringent in taste, cold in nature; it is externally used to detoxify and kill parasites, dry dampness and relieve itching. Gekko Swinhonis, salty and cold with slight toxicity. The functions are as follows: dispel wind, arresting convulsion, dissipate nodulation and remove toxicity. The invention takes angelica dahurica, mirabilite, rhubarb, alum and gecko as ministerial drugs to soften hard lumps and dissipate stagnation.
Long-noded pit viper, sweet and salty, warm and toxic; the functions are as follows: dispel wind-damp, penetrate tendons and bones, and arrest convulsions. Scorpio, pungent and Flat; the functions are as follows: extinguish wind and relieve spasm, dredge collaterals and alleviate pain, counteract toxic pathogen and dissipate nodulation. Wu Gong is warm in nature and pungent in flavor. The efficacy and the effect are as follows: extinguish wind, relieve spasm, counteract toxic pathogen, dissipate nodulation, dredge collaterals and alleviate pain. The invention takes long-noded pit viper, scorpion and centipede as adjuvant drugs, and has the functions of clearing away heat and toxic material and relieving pain.
The invention takes frankincense, myrrh, pangolin scales and zedoary as guiding drugs, and promotes blood circulation by removing blood stasis.
In conclusion, the traditional Chinese medicine composition takes radix angelicae, rheum officinale, scorpio, alum, mirabilite, centipede, mitsubishi, curcuma zedoary, gecko, dandelion, purslane, phaseolus calcaratus, frankincense, myrrh, agkistrodon and venenum bufonis as raw materials for compatibility, and has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain and softening hardness to dissipate stagnation by virtue of the synergic assistant and guide effects, so that the pain of a human body is relieved and conditioned.
The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 9-12 parts of radix angelicae, 9-12 parts of rheum officinale, 9-12 parts of scorpio, 3-6 parts of alum, 14-19 parts of mirabilite, 9-12 parts of centipede, 9-12 parts of mitsubishi, 9-12 parts of curcuma zedoary, 14-19 parts of gecko, 14-19 parts of dandelion, 20-25 parts of purslane, 14-19 parts of phaseolus calcaratus, 9-12 parts of frankincense, 9-12 parts of myrrh, 9-12 parts of long-noded pit viper and 1-5 parts of venenum bufonis.
The optimal proportion is as follows: 10 parts of angelica dahurica, 10 parts of rhubarb, 10 parts of scorpion, 5 parts of alum, 15 parts of mirabilite, 10 parts of centipede, 10 parts of mitsubishi, 10 parts of curcuma zedoary, 15 parts of gecko, 15 parts of dandelion, 20 parts of purslane, 15 parts of phaseolus calcaratus, 10 parts of frankincense, 10 parts of myrrh, 10 parts of long-noded pit viper and 3 parts of venenum bufonis.
In order to ensure that the drug effect quickly reaches the focus and facilitate the use, the traditional Chinese medicine preparation can be prepared into an external application preparation according to the following method:
(1) mixing radix Angelicae Dahuricae, herba Taraxaci, herba Portulacae, semen Phaseoli, rhizoma Sparganii, Curcumae rhizoma, Olibanum, Myrrha, and radix et rhizoma Rhei, and pulverizing to obtain mixed powder
Figure 100002_DEST_PATH_IMAGE001
；
(2) Independently crushing alum;
(3) mixing Agkistrodon, Scorpio, Scolopendra, and Gekko Swinhonis, and pulverizing to obtain mixed powder
Figure 333761DEST_PATH_IMAGE002
；
(4) Dissolving Bufonis venenum with wine;
(5) weathering and grinding mirabilite;
(6) firstly, mixing the powder
Figure 994549DEST_PATH_IMAGE001
Completely soaking in 10-15 times of vinegar-water, boiling with strong fire, decocting with slow fire for 30-50 min, concentrating to obtain extract, adding oleum Sesami, decocting, and adding the above mixed powder
Figure 340080DEST_PATH_IMAGE002
And Natrii sulfas powder, Alumen powder, and Bufonis venenum, and mixing with Mel to obtain unguent. Wherein the vinegar is edible vinegar, and the vinegar and water are mixed according to the volume ratio of 1: 1-1: 3. The addition amount of the linseed oil is 0.5-1.5 times of the volume of the extract.
The pain relieving effect of the drug prepared by the present invention will be described by clinical observation, taking a breast cancer patient as an example.
1. Observing an object: 32 patients with breast cancer.
2. The treatment method comprises the following steps: the paste medicine prepared in example 1 of the present invention was used. The ointment is applied to the skin of a focus part and is pasted by an adhesive tape for 3-4 hours every day.
3. And (4) observing results: within three hours, the pain of 13 patients is basically eliminated, and the pain of 16 patients is obviously relieved; the pain of 2 patients is relieved to a certain extent, but the pain is obvious; only 1 patient had no relief of pain.
The clinical tests show that the medicine of the present invention has good relieving and opsonizing effects on the pain caused by breast cancer, etc.
Tests also show that the medicine has good relieving and conditioning effects on pains caused by other cancers (esophagus cancer, gastric cancer, pancreatic cancer, gallbladder cancer, lung cancer, liver cancer and the like).
Detailed Description
The preparation method of the external application preparation of traditional Chinese medicine of the present invention is further explained by the following specific examples.
The formula is as follows: 10g of angelica dahurica, 10g of rhubarb, 10g of scorpion, 5g of alum, 15g of mirabilite, 10g of centipede, 10g of mitsubishi, 10g of curcuma zedoary, 15g of gecko, 15g of dandelion, 20g of purslane, 15g of phaseolus calcaratus, 10g of frankincense, 10g of myrrh, 10g of long-noded pit viper and 3g of toad venom.
The preparation method comprises the following steps:
1. mixing radix Angelicae Dahuricae, herba Taraxaci, herba Portulacae, semen Phaseoli, rhizoma Sparganii, Curcumae rhizoma, Olibanum, Myrrha, and radix et rhizoma Rhei, and pulverizing;
2. independently crushing alum;
3. mixing Agkistrodon, Scorpio, Scolopendra, and Gekko Swinhonis, and pulverizing;
4. dissolving Bufonis venenum with wine;
5. weathering and grinding mirabilite;
6. mixing 400ml of water and 300ml of vinegar, adding mixed powder of radix angelicae, dandelion, purslane, phaseolus calcaratus, mitsubishi, curcuma zedoary, frankincense, myrrh and rhubarb into the mixed powder, decocting the mixture with strong fire for boiling, and then decocting the mixture with slow fire for 30-50 minutes; concentrating the water decoction into paste, adding 200ml oleum Sesami, decocting, adding mixed powder of Agkistrodon, Scorpio, Scolopendra and Gekko Swinhonis, venenum Bufonis, Natrii sulfas and Alumen, and mixing with 300ml Mel to obtain paste medicine.
The usage and dosage are as follows: the ointment is smeared on the skin of a focus part and is pasted by an adhesive tape for 3-4 hours every day.

Claims (6)

1. An external preparation for relieving tumor pain is an external preparation prepared from radix Angelicae Dahuricae, radix et rhizoma Rhei, Scorpio, Alumen, Natrii sulfas, Scolopendra, rhizoma Mitsubishi, Curcumae rhizoma, Gekko Swinhonis, herba Taraxaci, herba Portulacae, semen Phaseoli, Olibanum, Myrrha, Agkistrodon, and Bufonis venenum as raw materials.
2. The topical formulation of claim 1, for relieving pain associated with a tumor, wherein: the raw materials are proportioned according to the following parts by weight:
9-12 parts of radix angelicae, 9-12 parts of rheum officinale, 9-12 parts of scorpio, 3-6 parts of alum, 14-19 parts of mirabilite, 9-12 parts of centipede, 9-12 parts of mitsubishi, 9-12 parts of curcuma zedoary, 14-19 parts of gecko, 14-19 parts of dandelion, 20-25 parts of purslane, 14-19 parts of phaseolus calcaratus, 9-12 parts of frankincense, 9-12 parts of myrrh, 9-12 parts of long-noded pit viper and 1-5 parts of venenum bufonis.
3. The topical formulation of claim 1, for relieving pain associated with a tumor, wherein: the raw materials are proportioned according to the following parts by weight:
10 parts of angelica dahurica, 10 parts of rhubarb, 10 parts of scorpion, 5 parts of alum, 15 parts of mirabilite, 10 parts of centipede, 10 parts of mitsubishi, 10 parts of curcuma zedoary, 15 parts of gecko, 15 parts of dandelion, 20 parts of purslane, 15 parts of phaseolus calcaratus, 10 parts of frankincense, 10 parts of myrrh, 10 parts of long-noded pit viper and 3 parts of venenum bufonis.
4. The method for preparing an external preparation for relieving tumor pain according to claim 1, comprising the steps of:
(1) mixing radix Angelicae Dahuricae, herba Taraxaci, herba Portulacae, semen Phaseoli, rhizoma Sparganii, Curcumae rhizoma, Olibanum, Myrrha, and radix et rhizoma Rhei, and pulverizing to obtain mixed powder
Figure DEST_PATH_IMAGE001
；
(2) Independently crushing alum;
(3) mixing Agkistrodon, Scorpio, Scolopendra, and Gekko Swinhonis, and pulverizing to obtain mixed powder
Figure 341549DEST_PATH_IMAGE002
；
(4) Dissolving Bufonis venenum with wine;
(5) weathering and grinding mirabilite;
(6) completely soaking the mixed powder in 10-15 times of vinegar-water, boiling with strong fire, then decocting with slow fire for 30-50 minutes, concentrating into extract, adding linseed oil, heating, and then adding the mixed powder
Figure 524269DEST_PATH_IMAGE002
And Natrii sulfas powder, Alumen powder, and Bufonis venenum, mixing with Mel, and making into ointment.
5. The method of preparing an external preparation for relieving tumor pain according to claim 4, wherein the vinegar is edible vinegar, and the vinegar is mixed with water at a volume ratio of 1:1 to 1: 3.
6. The method for preparing an external preparation for relieving tumor pain as claimed in claim 1, wherein the amount of the sesame oil added is 0.5-1.5 times the volume of the extract.
CN202010321044.XA 2020-04-22 2020-04-22 External preparation for relieving tumor pain Pending CN111329977A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101513509A (en) * 2008-02-23 2009-08-26 张明 Medicament for relieving cancer symptoms and method for preparing same
CN101745064A (en) * 2008-12-15 2010-06-23 张瑞兴 Cancer pain killing paste
CN105641346A (en) * 2016-01-30 2016-06-08 吴谋军 Transdermal analgesic free of toxic and side effects and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101513509A (en) * 2008-02-23 2009-08-26 张明 Medicament for relieving cancer symptoms and method for preparing same
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