CN111329956A - Plaster with analgesic effect, and preparation method and application method thereof - Google Patents

Plaster with analgesic effect, and preparation method and application method thereof Download PDF

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CN111329956A
CN111329956A CN202010240577.5A CN202010240577A CN111329956A CN 111329956 A CN111329956 A CN 111329956A CN 202010240577 A CN202010240577 A CN 202010240577A CN 111329956 A CN111329956 A CN 111329956A
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parts
root
radix
plaster
analgesic effect
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程晋步
程芳芳
范先明
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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Abstract

The invention discloses a wanying paste with an analgesic effect, which comprises the following components in parts by weight: 15-35 parts of raw common monkshood mother root, 15-35 parts of raw kusnezoff monkshood root, 10-30 parts of dahurian angelica root, 10-30 parts of Chinese angelica, 10-30 parts of lightyellow sophora root, 10-30 parts of stir-baked squama manitis, 5-25 parts of dried rehmannia root, 5-25 parts of radix ampelopsis, 5-25 parts of bletilla striata, 5-25 parts of prepared elephant hide, 5-25 parts of cassia bark, 5-25 parts of red paeony root, 5-25 parts of incised notopterygium rhizome and root, 5-25 parts of combined spicebush root, 5-25 parts of liquoric root, 5-25 parts of doubleteeth pubescent angelica root, 5-25 parts of radix scrophulariae, 5-25 parts of eupolyphaga; the medicine has multiple pharmacological functions and can be used for relieving pain of various diseases; and the transdermal absorption degree is very high, and the analgesic effect is obvious. The invention also provides a preparation method and a use method of the wanying ointment, and the prepared wanying ointment has the characteristic of good transdermal absorption effect.

Description

Plaster with analgesic effect, and preparation method and application method thereof
Technical Field
The invention relates to the technical field of medical drugs, in particular to a wanying ointment with an analgesic effect, a preparation method and a use method thereof.
Background
Pain, a complex physiological and psychological activity, is one of the most common clinical symptoms. In particular, chronic pain has become an intolerable affliction to the body. Thus, analgesia is an important task faced by medical practitioners, who are responsible for helping patients eliminate pain without affecting their observations. Analgesia is a treatment mode for chronic pain, various analgesia modes are available, the analgesia mode in the market at present is mainly realized by conditioning and relieving traditional Chinese medicines, the types of the medicinal materials used for analgesia are different, but most of the analgesia modes are realized by adopting external plaster, external application and other modes for treatment. In addition, because the dermal tissue of the body has a barrier effect, the traditional Chinese medicine ingredients in the formula of the externally applied plaster are difficult to permeate to the affected part through the surface layer of the skin, thereby being not beneficial to achieving the effect of relieving pain; meanwhile, the formula of the externally applied plaster for treating pain in the prior art has the following defects: the effective components can not be completely absorbed, which causes the waste of medicinal materials; the transdermal effect is poor, so that the analgesic effect is not obvious; the pharmacological functions are few, which causes the problems of narrow application range, small disease treatment range and the like.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the wanyinggao with the analgesic effect, which has multiple pharmacological functions and can be used for relieving pains of various diseases; and the transdermal absorption degree is very high, the analgesic effect is obvious, and the waste caused by insufficient absorption of medicinal materials can be effectively avoided.
The second purpose of the invention is to provide the preparation method of the wanying ointment with the analgesic effect, which is the first purpose of the invention, the preparation method has simple process and convenient operation, and the prepared wanying ointment has the characteristic of good transdermal absorption effect.
The third purpose of the invention is to provide a using method of the plaster with analgesic effect, which can make the components of the plaster fully exert synergistic effect and achieve remarkable analgesic effect.
One of the purposes of the invention is realized by adopting the following technical scheme:
the plaster with the analgesic effect is characterized by comprising the following components in parts by weight:
15-35 parts of raw common monkshood mother root, 15-35 parts of raw kusnezoff monkshood root, 10-30 parts of dahurian angelica root, 10-30 parts of Chinese angelica, 10-30 parts of lightyellow sophora root, 10-30 parts of stir-baked pangolin scales, 5-25 parts of dried rehmannia root, 5-25 parts of radix ampelopsis, 5-25 parts of bletilla striata, 5-25 parts of prepared elephant hide, 5-25 parts of cassia bark, 5-25 parts of red paeony root, 5-25 parts of incised notopterygium rhizome and root, 5-25 parts of combined spicebush root, 5-25 parts of liquoric root, 5-25 parts of doubleteeth pubescent angelica root, 5-25 parts of scrophularia, 5-25 parts of.
Further, the dissolving agent is sesame oil.
Further, the adhesive is Plumbum Preparatium.
Further, the paint comprises the following components in parts by weight:
20-30 parts of unprocessed radix aconiti, 20-30 parts of unprocessed radix aconiti kusnezoffii, 15-25 parts of angelica dahurica, 15-25 parts of angelica, 15-25 parts of sophora flavescens, 15-25 parts of stir-baked squama manitis, 10-20 parts of radix rehmanniae, 10-20 parts of radix ampelopsis, 10-20 parts of bletilla striata, 10-20 parts of prepared elephant hide, 10-20 parts of cassia bark, 10-20 parts of red paeony root, 10-20 parts of notopterygium root, 10-20 parts of radix linderae, 10-20 parts of liquorice, 10-20 parts of radix angelicae pubescentis, 10-20 parts of radix scrophulariae, 10-20 parts of eupolyphaga, 3200 parts of a lytic agent 2800-.
Further, the paint comprises the following components in parts by weight:
25 parts of unprocessed radix aconite, 25 parts of unprocessed radix aconiti kusnezoffii, 20 parts of angelica dahurica, 20 parts of angelica, 20 parts of radix sophorae flavescentis, 20 parts of stir-baked squama manitis, 15 parts of radix rehmanniae, 15 parts of radix ampelopsis, 15 parts of bletilla striata, 15 parts of prepared elephant hide, 15 parts of cassia bark, 15 parts of red paeony root, 15 parts of notopterygium root, 15 parts of combined spicebush root, 15 parts of liquorice, 15 parts of radix angelicae pubescentis, 15 parts of radix scrophulariae, 15 parts of eupolyphaga, 3000 parts of.
The second purpose of the invention is realized by adopting the following technical scheme:
the preparation method of the wanying paste with the analgesic effect, which is one of the purposes of the invention, is characterized by comprising the following steps:
and (3) chopping: cutting radix Aconiti, radix Aconiti Kusnezoffii, radix Angelicae Dahuricae, radix Angelicae sinensis, radix Sophorae Flavescentis, squama Manis preparata, radix rehmanniae, radix Ampelopsis, rhizoma Bletillae, cortex Elephatis chinensis preparata, cortex Cinnamomi Japonici, radix Paeoniae Rubra, Notopterygii rhizoma, radix Linderae, Glycyrrhrizae radix, radix Angelicae Pubescentis, radix scrophulariae and Eupolyphaga Seu Steleophaga, and mixing to obtain mixture;
soaking and decocting: adding a dissolving agent with a formula amount into the mixture for soaking, then decocting for 20-30 hours, filtering after the medicinal materials are changed to be yellow, taking the filtrate, and continuously decocting for 24-48 hours until the filtrate can be dripped into water to form beads, thus obtaining a concentrated solution;
forming paste: adding binder into the concentrated solution, stirring, cooling, and solidifying to obtain WANYING ointment with analgesic effect.
Further, in the step of soaking and decocting, the soaking time is 7 days; the boiling is carried out by adopting medium fire; the filtration is carried out by adopting double-layer gauze.
Further, in the step of forming the paste, the weight of the added binder is half of the weight of the concentrated solution.
Further, the step of forming the plaster also comprises a step of coating the plaster, wherein the step of coating the plaster with the analgesic effect is to coat the plaster on a sticky bandage adhesive plaster, and then fold the side coated with the plaster with the analgesic effect in half for standby.
The third purpose of the invention is realized by adopting the following technical scheme:
the application method of the wanyinggao with the analgesic effect is characterized in that the wanyinggao with the analgesic effect is heated by small fire until the folded surface is opened when the wanyinggao is used, and then the wanyinggao is pasted on an affected part.
Compared with the prior art, the invention has the beneficial effects that:
1. the wanying plaster with the analgesic effect provided by the invention is prepared by reasonably matching raw radix aconiti, raw radix aconiti kusnezoffii, radix angelicae, angelica sinensis, radix sophorae flavescentis and stir-fried pangolin scales, and then playing a role together with the components of radix rehmanniae, radix ampelopsis, bletilla striata, prepared elephant hide, cassia bark, radix paeoniae rubra, notopterygium root, combined spicebush root, liquorice, radix angelicae pubescentis, radix scrophulariae, eupolyphaga and the like, so that the pain caused by various diseases is alleviated, the application range is very wide, and especially the pain caused by diseases such as rheumatic arthralgia, sore and swelling pain, neck and waist pain, hyperplasia of mammary glands, traumatic injury, fracture and injury of tendons, intercostal; especially has obvious analgesic effect on intercostal nerve pain, rheumatic arthralgia and neck and waist pain.
2. The dissolving agent of the wanying ointment with the analgesic effect provided by the invention is set as sesame oil, so that analgesic ingredients in the medicine can be effectively extracted and dissolved in the sesame oil, and the analgesic effect can be fully exerted.
3. The preparation method of the wanying paste with the analgesic effect can fully extract and protect the effective analgesic ingredients in the raw radix aconiti, the raw radix aconiti agrestis, the radix angelicae, the angelica sinensis, the radix sophorae flavescentis and the stir-baked squama manitis, and ensure that the effective ingredients in the wanying paste can play the analgesic effect, thereby effectively resisting the pain caused by various diseases; the wanying ointment prepared by the preparation method has excellent transdermal absorption effect, can well play a role in easing pain, and can effectively avoid waste caused by insufficient absorption of medicinal materials.
Drawings
Fig. 1 is a picture of the plaster for treating pain of the present invention.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment. The equipment and raw materials used are all available on the market or commonly used in the field. The methods in the following examples are conventional in the art unless otherwise specified.
As shown in fig. 1, the plaster with analgesic effect comprises the following components in parts by weight:
15-35 parts of raw common monkshood mother root, 15-35 parts of raw kusnezoff monkshood root, 10-30 parts of dahurian angelica root, 10-30 parts of Chinese angelica, 10-30 parts of lightyellow sophora root, 10-30 parts of stir-baked pangolin scales, 5-25 parts of dried rehmannia root, 5-25 parts of radix ampelopsis, 5-25 parts of bletilla striata, 5-25 parts of prepared elephant hide, 5-25 parts of cassia bark, 5-25 parts of red paeony root, 5-25 parts of incised notopterygium rhizome and root, 5-25 parts of combined spicebush root, 5-25 parts of liquoric root, 5-25 parts of doubleteeth pubescent angelica root, 5-25 parts of scrophularia, 5-25 parts of.
As a further embodiment, the dissolution agent is sesame oil.
As a further embodiment, the binder is minium.
As a further embodiment, the composition comprises the following components in parts by weight:
20-30 parts of unprocessed radix aconiti, 20-30 parts of unprocessed radix aconiti kusnezoffii, 15-25 parts of angelica dahurica, 15-25 parts of angelica, 15-25 parts of sophora flavescens, 15-25 parts of stir-baked squama manitis, 10-20 parts of radix rehmanniae, 10-20 parts of radix ampelopsis, 10-20 parts of bletilla striata, 10-20 parts of prepared elephant hide, 10-20 parts of cassia bark, 10-20 parts of red paeony root, 10-20 parts of notopterygium root, 10-20 parts of radix linderae, 10-20 parts of liquorice, 10-20 parts of radix angelicae pubescentis, 10-20 parts of radix scrophulariae, 10-20 parts of eupolyphaga, 3200 parts of a lytic agent 2800-.
As a further embodiment, the composition comprises the following components in parts by weight:
25 parts of unprocessed radix aconite, 25 parts of unprocessed radix aconiti kusnezoffii, 20 parts of angelica dahurica, 20 parts of angelica, 20 parts of radix sophorae flavescentis, 20 parts of stir-baked squama manitis, 15 parts of radix rehmanniae, 15 parts of radix ampelopsis, 15 parts of bletilla striata, 15 parts of prepared elephant hide, 15 parts of cassia bark, 15 parts of red paeony root, 15 parts of notopterygium root, 15 parts of combined spicebush root, 15 parts of liquorice, 15 parts of radix angelicae pubescentis, 15 parts of radix scrophulariae, 15 parts of eupolyphaga, 3000 parts of.
The preparation method of the wanying ointment with the analgesic effect comprises the following steps:
and (3) chopping: cutting radix Aconiti, radix Aconiti Kusnezoffii, radix Angelicae Dahuricae, radix Angelicae sinensis, radix Sophorae Flavescentis, squama Manis preparata, radix rehmanniae, radix Ampelopsis, rhizoma Bletillae, cortex Elephatis chinensis preparata, cortex Cinnamomi Japonici, radix Paeoniae Rubra, Notopterygii rhizoma, radix Linderae, Glycyrrhrizae radix, radix Angelicae Pubescentis, radix scrophulariae and Eupolyphaga Seu Steleophaga, and mixing to obtain mixture;
soaking and decocting: adding a dissolving agent with a formula amount into the mixture for soaking, then decocting for 20-30 hours, filtering after the medicinal materials are changed to be yellow, taking the filtrate, and continuously decocting for 24-48 hours until the filtrate can be dripped into water to form beads, thus obtaining a concentrated solution;
the operation of dripping water into beads comprises the following steps: preparing a bowl of cold water, continuously stirring the liquid medicine by using a spoon, quickly lifting the spoon to the position above the cold water bowl, and dripping the liquid medicine on the spoon into the bowl, wherein if the liquid medicine can be sunk into the bottom of the bowl in a bead-dropping shape and can not be dissolved by the cold water in the bowl, the liquid medicine is dripped into beads.
Forming paste: adding binder into the concentrated solution, stirring, cooling, and solidifying to obtain WANYING ointment with analgesic effect.
As a further embodiment, in the step of soaking and decocting, the soaking time is 7 days; the boiling is carried out by adopting medium fire; the filtration is carried out by adopting double-layer gauze.
As a further embodiment, in the step of forming the paste, the weight of the binder added is half of the weight of the concentrate.
As a further embodiment, the step of forming the plaster further comprises a step of applying plaster, wherein the step of applying plaster with analgesic effect is to coat the plaster on the bandage adhesive plaster with viscosity, and then the side coated with plaster with analgesic effect is folded in half for standby.
The application method of the WANYING ointment with analgesic effect comprises heating the WANYING ointment with analgesic effect with slow fire until the folded surface is opened, and applying on affected part.
Examples 1 to 4:
the wanying ointment with the analgesic effect is prepared by weighing the components in parts by weight in the table 1 and preparing the wanying ointment with the analgesic effect according to the following steps, wherein a dissolving agent is sesame oil, and a binding agent is minium:
table 1: EXAMPLES 1-4 ingredient distribution ratio Table
Figure BDA0002430542030000071
Figure BDA0002430542030000081
The components are prepared according to the following steps:
and (3) chopping: cutting radix Aconiti, radix Aconiti Kusnezoffii, radix Angelicae Dahuricae, radix Angelicae sinensis, radix Sophorae Flavescentis, squama Manis preparata, radix rehmanniae, radix Ampelopsis, rhizoma Bletillae, cortex Elephatis chinensis preparata, cortex Cinnamomi Japonici, radix Paeoniae Rubra, Notopterygii rhizoma, radix Linderae, Glycyrrhrizae radix, radix Angelicae Pubescentis, radix scrophulariae and Eupolyphaga Seu Steleophaga, and mixing to obtain mixture;
soaking and decocting: adding a dissolving agent with the formula amount into the mixture, soaking for 7 days, decocting with medium fire for 24 hours, filtering with double-layer gauze after the medicinal materials turn yellow, taking the filtrate, and continuously decocting for 24-48 hours until the filtrate can drip water to form beads, thus obtaining a concentrated solution;
forming paste: adding binder into the concentrated solution, stirring, cooling, and solidifying to obtain WANYING ointment with analgesic effect.
Coating paste: the prepared wanying plaster with analgesic effect is coated on a sticky bandage adhesive plaster, and then the side coated with the wanying plaster with analgesic effect is folded in half for standby.
The application method of the wanying paste with analgesic effect prepared in the examples 1 to 4 comprises the following steps: when in use, the plaster with analgesic effect is heated with small fire until the folded surface is opened, and then applied to the affected part.
Verification of the examples:
1. clinical data: selecting 40 patients from the patients in the health hospital, wherein the patients have the diseases of rheumatalgia, carbuncle sore, swelling and pain, neck and waist pain, hyperplasia of mammary glands, traumatic injury, fracture and injury of tendons, intercostal nerve pain, hyperosteogeny and the like.
2. The observation method comprises the following steps: 40 patients are numbered according to the clinic sequence, the first 1-10 patients are A group, the first 11-20 patients are B group, the first 21-30 patients are C group, the first 31-40 patients are D group, A, B, C, D group patients use the plaster with analgesic effect prepared in the embodiment 1-4 to paste on the affected part, the medicine is changed once every 24 hours, one treatment course is provided every week, and three weeks are continuously observed.
3. Grading pain: the method is divided into four stages.
Level 0: has no pain.
Level 1: mild pain: the local part has slight tenderness, and the affected part has activity pain when moving greatly, has no spontaneous pain, and has no obvious influence on daily work and life.
And 2, stage: moderate pain: the affected part has obvious tenderness, pain during activity and slight spontaneous pain, and has certain influence on daily work and life.
And 3, level: severe pain: the affected part has persistent spontaneous severe pain, and restricts the activity of the patient, affecting daily work and life.
4. The scoring method comprises the following steps: according to the pain degree of clinical observation, the pain degree is divided into 0-3 grades of pain, 0 grade of pain is calculated and divided into 0 grade, 1 grade of pain is calculated and divided into 1 grade, 2 grade of pain is calculated and divided into 2 grade, and 3 grade of pain is calculated and divided into 3 grade; a pain meter rating of 0.5 between class 0 and class 1, a pain meter rating of 1.5 between class 1 and class 2, and a pain meter rating of 2.5 between class 2 and class 3. The pain level of the patients was observed and scored before the treatment, and after the treatment was completed, the pain level of the patients was observed again and scored, and then the percentage of decrease in pain after the treatment was calculated as a basis for evaluating the efficacy.
The percentage reduction in pain after treatment was calculated as: (post-treatment pain score-pre-treatment pain score)/pre-treatment pain score; the result is positive number is rising and negative number is falling.
Such as: if a patient had 3 grades of pain before treatment and 1 grade of pain after treatment, the percentage of pain reduction after treatment was-66.7% (1-3)/3), i.e., 66.7% of pain reduction after treatment.
5. Criteria for efficacy assessment
(1) And healing completely: the percentage of pain reduction after treatment was more than 83%.
(2) Remarkably: the percentage of pain reduction after treatment was 70-82%.
(3) And (3) improvement: the percentage decrease in pain after treatment was 52-69%.
(4) And (3) invalidation: the percentage of pain reduction after treatment was less than 51%.
6. The treatment effect is as follows: the therapeutic effect of the patients in groups A-D in the clinical trial is shown in Table 2.
Table 2 shows the therapeutic effect of the patients in groups A to D
Figure BDA0002430542030000101
Figure BDA0002430542030000111
As can be seen from table 2, the total effective rate of the wanying paste with analgesic effect of the present invention reaches 100% when treating diseases such as rheumatic arthralgia, carbuncle sore swelling and pain, neck and waist pain, hyperplasia of mammary glands, traumatic injury, fracture injury of tendons, intercostal nerve pain and hyperosteogeny, wherein the treatment with significant curative effect reaches 57.5%.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.

Claims (10)

1. The plaster with the analgesic effect is characterized by comprising the following components in parts by weight:
15-35 parts of raw common monkshood mother root, 15-35 parts of raw kusnezoff monkshood root, 10-30 parts of dahurian angelica root, 10-30 parts of Chinese angelica, 10-30 parts of lightyellow sophora root, 10-30 parts of stir-baked pangolin scales, 5-25 parts of dried rehmannia root, 5-25 parts of radix ampelopsis, 5-25 parts of bletilla striata, 5-25 parts of prepared elephant hide, 5-25 parts of cassia bark, 5-25 parts of red paeony root, 5-25 parts of incised notopterygium rhizome and root, 5-25 parts of combined spicebush root, 5-25 parts of liquoric root, 5-25 parts of doubleteeth pubescent angelica root, 5-25 parts of scrophularia, 5-25 parts of.
2. The pancreatin ointment with analgesic effect of claim 1, wherein the dissolving agent is sesame oil.
3. The plaster of claim 1, wherein the binder is Plumbum Preparatium.
4. The panchrest plaster with the analgesic effect according to claim 1, which is characterized by comprising the following components in parts by weight:
20-30 parts of unprocessed radix aconiti, 20-30 parts of unprocessed radix aconiti kusnezoffii, 15-25 parts of angelica dahurica, 15-25 parts of angelica, 15-25 parts of sophora flavescens, 15-25 parts of stir-baked squama manitis, 10-20 parts of radix rehmanniae, 10-20 parts of radix ampelopsis, 10-20 parts of bletilla striata, 10-20 parts of prepared elephant hide, 10-20 parts of cassia bark, 10-20 parts of red paeony root, 10-20 parts of notopterygium root, 10-20 parts of radix linderae, 10-20 parts of liquorice, 10-20 parts of radix angelicae pubescentis, 10-20 parts of radix scrophulariae, 10-20 parts of eupolyphaga, 3200 parts of a lytic agent 2800-.
5. The panchrest plaster with the analgesic effect according to claim 1, which is characterized by comprising the following components in parts by weight:
25 parts of unprocessed radix aconite, 25 parts of unprocessed radix aconiti kusnezoffii, 20 parts of angelica dahurica, 20 parts of angelica, 20 parts of radix sophorae flavescentis, 20 parts of stir-baked squama manitis, 15 parts of radix rehmanniae, 15 parts of radix ampelopsis, 15 parts of bletilla striata, 15 parts of prepared elephant hide, 15 parts of cassia bark, 15 parts of red paeony root, 15 parts of notopterygium root, 15 parts of combined spicebush root, 15 parts of liquorice, 15 parts of radix angelicae pubescentis, 15 parts of radix scrophulariae, 15 parts of eupolyphaga, 3000 parts of.
6. A method for preparing WANYING ointment with analgesic effect according to any one of claims 1 to 5, characterized by comprising the following steps:
and (3) chopping: cutting radix Aconiti, radix Aconiti Kusnezoffii, radix Angelicae Dahuricae, radix Angelicae sinensis, radix Sophorae Flavescentis, squama Manis preparata, radix rehmanniae, radix Ampelopsis, rhizoma Bletillae, cortex Elephatis chinensis preparata, cortex Cinnamomi Japonici, radix Paeoniae Rubra, Notopterygii rhizoma, radix Linderae, Glycyrrhrizae radix, radix Angelicae Pubescentis, radix scrophulariae and Eupolyphaga Seu Steleophaga, and mixing to obtain mixture;
soaking and decocting: adding a dissolving agent with a formula amount into the mixture for soaking, then decocting for 20-30 hours, filtering after the medicinal materials are changed to be yellow, taking the filtrate, and continuously decocting for 24-48 hours until the filtrate can be dripped into water to form beads, thus obtaining a concentrated solution;
forming paste: adding binder into the concentrated solution, stirring, cooling, and solidifying to obtain WANYING ointment with analgesic effect.
7. The method for preparing WANYING ointment with analgesic effect as claimed in claim 6, wherein in the step of soaking and decocting, the soaking time is 7 days; the boiling is carried out by adopting medium fire; the filtration is carried out by adopting double-layer gauze.
8. The method for preparing WANYING ointment with analgesic effect as claimed in claim 6, wherein in the step of forming ointment, the weight of the added binder is half of the weight of the concentrated solution.
9. The method for preparing WANYING PLASTER WITH ANALGESIC ACTION according to claim 6, wherein the step of forming the plaster further comprises a step of pasting the plaster, wherein the step of pasting is to coat the plaster on a sticky bandage adhesive plaster, and then to fold the side coated with the WANYING PLASTER with ANALGESIC ACTION in half for standby.
10. The use method of the plaster with analgesic effect according to claim 9, characterized in that, in use, the plaster with analgesic effect is heated with small fire until the folded surface is opened, and then applied to the affected part.
CN202010240577.5A 2020-03-30 2020-03-30 Plaster with analgesic effect, and preparation method and application method thereof Pending CN111329956A (en)

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Publication number Priority date Publication date Assignee Title
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Publication number Priority date Publication date Assignee Title
CN1306850A (en) * 2000-01-27 2001-08-08 陈晓阳 Spur ointment
CN1327822A (en) * 2000-12-29 2001-12-26 莱芜市中医医院 Universal red Zn-base ointment for treating injury and its prparing process
CN101474358A (en) * 2009-01-15 2009-07-08 刘秋成 External plaster for treating zoster

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Application publication date: 20200626