CN1327822A - Universal red Zn-base ointment for treating injury and its prparing process - Google Patents

Abstract

A universal red Zn-base ointment for treating ulcer diseases such as carbuncle, tumor ulcer, etc. is prepared from more than 20 Chinese-medicinal materials including cottonrose libiscus leaf, Sichuan aconite root, wild aconite root, rehmannia root, etc. Its advantages include no black pollution, low viscosity, and low flowability.

Description

Infections section zinc-base redness ten thousand is answered ointment and preparation method thereof

The invention belongs to a kind of ointment and preparation method thereof, particularly a kind of infections section zinc-base redness ten thousand is answered ointment and preparation method thereof, is applicable to diseases such as carbuncle carbuncle on the back, boil on the nape opposite the mouth, sucutaneous nodule fluidization tower, abscess ulcer.

At present, for diseases such as carbuncle carbuncle on the back, boil on the nape opposite the mouth, sucutaneous nodule fluidization tower, abscess ulcer, multiple therapy methods is arranged, oral medicine, application compress etc. are arranged, wherein the most frequently used is at the affected area externally applied plaster, and becoming black plaster, main component as Wang Qi is the fatty acid in the oils and fats and the main component Pb of Plumbum preparatium ₃O ₄Fully react the black lead stearate that generates, red oil ratio is 210: 500; Strengthen black plaster Transdermal absorption experimentation and DONGFANG HUOXUE GAO for another example, these researchs all with the Qing Dynasty " the new method gist of Yizong Jinjian surgery " " plaster side " in " panchrest plaster " one section in description consistent, these cream belong to the category of black-lead plaster, use proof, truly have the effect of " dispelling pathogenic wind and eliminating phlegm, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting, dispelling toxins and dredging collaterals ", aspect treatment " carbuncle carbuncle on the back, boil on the nape opposite the mouth, sucutaneous nodule fluidization tower " disease curative effect is preferably being arranged.But because this plaster adopts the Plumbum preparatium powder as substrate, so prolonged application the lead poisoning phenomenon can occur in larger area open sore part infections face, because this kind plaster hygroscopicity is poor, concurrent contact dermatitis from plaster appears in the patient who has quite a few open sore part infections face pus to soak taste, eczema promptly appears, dermatitis, in order to get rid of the generation of lead poisoning phenomenon, so there is the people to adopt unleaded ointment, as application number the patent application of a kind of lead-free plaster of 94101500 and preparation method thereof, though unleaded, avoided the lead poisoning phenomenon, but adopted the high temperature oil-refining method, make oily blackening,, have black pollution during application so the plaster of producing still is the hard black plaster, substrate and the equal blackening of ointment under the high temperature simultaneously, it is unreasonable with the proportioning of receiving cream base matter to add its medicine oil base, and viscosity is big, in application process, it is poor to exist soft slip, the sensation that has the hard adhesion of plate not relax, to focus depression crease place or big face ulcer place, this sensation is more obvious especially.

The object of the present invention is to provide a kind of not only in application soft slip good, the no plate Uncomfortable feeling of adhering firmly, and the infections section zinc-base redness ten thousand of not having a black pollution is answered ointment.

The present invention is achieved in that this infections section zinc-base redness ten thousand answers ointment to contain the Hibisci Mutabilis floral leaf, Radix Aconiti, Radix Aconiti Kusnezoffii, the Radix Rehmanniae, Radix Ampelopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Corium elephatis, Radix Paeoniae Rubra, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Semen Momordicae, Squama Manis, the Radix Linderae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, clean Oleum sesami and Calamina (forging) powder, its preceding 20 herbal medicine each component proportionings are: the Hibisci Mutabilis floral leaf accounts for 8-12%, Radix Aconiti, Radix Aconiti Kusnezoffii, the Radix Rehmanniae, Radix Ampelopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Corium elephatis, Radix Paeoniae Rubra, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Semen Momordicae, Squama Manis, the Radix Linderae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, the Radix Et Rhizoma Rhei sum accounts for 88-92%, and be equivalent, 20 flavor component medicine gross weights are 1: 7.5～8.5 with the ratio of clean Oleum sesami weight.

The manufacturing procedure of this ointment is followed successively by:

(1) softening process: at first get each medicine component raw material ready, take by weighing weight more in proportion, the preceding 20 flavor medicines that proportioning is good mix earlier, and be processed into coarse powder, soaked 72-240 hour with clean Oleum sesami in container, 20 flavor component medicine gross weights are 1: 7.5～8.5 with the ratio of clean Oleum sesami weight, make it softening till, winter, soak time was long, and summer, soak time was short:

(2) boil medicine oil: soak softening after, boil again, with 200-220 ℃ of mild and heavy respiration explosive, friedly be dark brown to the pharmaceutical presentations face, medicinal residues are dragged for after being coke yellow in inside, i.e. patent medicine oil;

(3) refining medicine oil: with 300-320 ℃ of intense fire oil refining, refine to medicine oil meter face and emit white dense smoke, the boiling oil bloom are assembled to pot central authorities, and it is splashed in the water till the Cheng Zhu;

(4) substrate under the temperature control: after the truce; when treating that the medicine oil temperature is reduced to 95～100 ℃; slowly drop into Calamina (forging) powder and stir evenly, stir while dropping into, Calamina (forging) powder is 1～1.5: 1 with the ratio of medicine weight of oil; stir to cream and stick with paste when being pale red; become ointment in the impouring cold water, paste at the stand at last, makes it soften into rare flowing soaking paste; radial stand is affixed on mounts on the cloth (or paper), and it is standby to get product.

Advantage of the present invention is: compare with existing " panchrest plaster ", because substrate is used Calamina (forging) powder instead by original Plumbum preparatium powder, so reached unleaded purpose, overcome the lead poisoning phenomenon, simultaneously, mainly contain zinc oxide in Calamina (forging) powder, its sweet in the mouth is flat, can detoxify, the moisture absorption granulation promoting, removing nebula makes eye bright, can control ulcer being unable to heal, skin eczema and conjunctival congestion cataracta are rotted string, wind-eye, so improved hygroscopicity and promoting tissue regeneration and wound healing is held back skin, subduing swelling and relieving pain, eliminating pus and slough, the effect of detoxifcation: owing to increased the Hibisci Mutabilis floral leaf in the component of spice, its acrid in the mouth is flat, but removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain; Compare with lead-free plaster and preparation method, because at the rational proportion that has adopted substrate and substrate and medicine oil under mild and heavy respiration explosive, intense fire refining medicine oil, the temperature control on the technology, so, the ointment of producing is a Hibisci Mutabilis style pale red, so changed original black pollution, has reached the purpose that non-soap (deceiving) is changed, become semisolid stiff ointment simultaneously, overcome the shortcoming of plaster, in addition, this ointment has also that viscosity is low, elasticity is high, be difficult for sliding, be difficult for advantage such as slime flux.

Embodiment 1

The screening raw material is prepared enough each component.Take by weighing Hibisci Mutabilis floral leaf 15 grams, account for 9.5%, Radix Aconiti, Radix Aconiti Kusnezoffii, the Radix Rehmanniae, Radix Ampelopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Corium elephatis, Radix Paeoniae Rubra, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Semen Momordicae, Squama Manis, the Radix Linderae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei sum are 142.5 grams, account for 90.5%, respectively be 7.5 grams, the ratio that accounts for 4.76%, 20 flavor component medicine gross weight and clean Oleum sesami weight is 1: 8, Calamina (forging) powder capacity.Preceding 20 flavor medicines are mixed earlier and make coarse powder; be soaked in the clean Oleum sesami, soak time 72 hours, make it softening till; after softening; boil medicine oil again,, fried be dark brown to the pharmaceutical presentations face with 200 ℃ of mild and heavy respiration explosives; medicinal residues patent medicine oil is dragged for after being coke yellow in inside; refine medicine oil again,, refine to medicine oil meter face and emit white dense smoke with 300 ℃ of intense fires refining medicine oil; the boiling oil bloom are assembled to pot central authorities; splash in the water till the Cheng Zhu; substrate under the temperature control is ceased fire, when the medicine oil temperature is reduced to 95 ℃ again; slowly drop into Calamina (forging) powder in 1: 1 ratio; stir while dropping into, stir evenly, stir when ointment is pale red; become ointment in the impouring cold water; paste at the stand at last, and radial stand is affixed on mounts on the cloth (or paper), gets product.

Embodiment 2

The screening raw material is prepared enough each component.Take by weighing Hibisci Mutabilis floral leaf 30 grams; Radix Aconiti; Radix Aconiti Kusnezoffii; the Radix Rehmanniae; Radix Ampelopsis; the Pseudobulbus Bletillae (Rhizoma Bletillae); Corium elephatis; Radix Paeoniae Rubra; Cortex Cinnamomi; the Radix Angelicae Dahuricae; Radix Angelicae Sinensis; Rhizoma Et Radix Notopterygii; Radix Sophorae Flavescentis; Semen Momordicae; Squama Manis; the Radix Linderae; Radix Glycyrrhizae; Radix Angelicae Pubescentis; Radix Scrophulariae; each 15 gram of Radix Et Rhizoma Rhei; 20 flavor component gross weights are 1: 7.5 with the ratio of clean Oleum sesami weight; Calamina (forging) powder capacity; preceding 20 flavor medicines are mixed earlier and make coarse powder; be soaked in the clean Oleum sesami; soak time 200 hours; till making it softening; boil medicine oil again; with 220 ℃ of mild and heavy respiration explosives; fried be dark brown to the pharmaceutical presentations face; medicinal residues patent medicine oil is dragged for after being coke yellow in inside; refine medicine oil again; with 330 ℃ of refinings of intense fire medicine oil; refine to medicine oil meter face and emit white dense smoke; the boiling oil bloom are assembled to pot central authorities; splash in the water till the Cheng Zhu; substrate under the temperature control again; cease fire; when the medicine oil temperature is reduced to 100 ℃; 1.5: 1 ratio of ratio in Calamina (forging) powder and medicine weight of oil slowly drops into Calamina (forging) powder, stirs while dropping into, and stirs evenly; stir to cream and stick with paste when being pale red; become ointment in the impouring cold water, paste at the stand at last, can directly spread out subsides under the high environment of summer or temperature; can be warm a little under winter or low temperature environment; make it soften into rare flowing soaking paste, radial stand is affixed on mounts on the cloth (or paper), gets product.

Embodiment 3

The screening raw material is prepared enough each component.Take by weighing Hibisci Mutabilis floral leaf 60 grams, account for 10.2%, Radix Aconiti, Radix Aconiti Kusnezoffii, the Radix Rehmanniae, Radix Ampelopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Corium elephatis, Radix Paeoniae Rubra, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Semen Momordicae, Squama Manis, the Radix Linderae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei total amount are 530 grams, account for 89.8%, each 30 gram, the ratio that accounts for 4.73%, 20 flavor component medicine gross weight and clean Oleum sesami weight is 1: 8.5, Calamina (forging) powder capacity.Preceding 20 flavor medicines are mixed earlier and make coarse powder; be soaked in the clean Oleum sesami, soak time 100 hours makes it softening; boil medicine oil again; with 210 ℃ of mild and heavy respiration explosives, fried be dark brown to the pharmaceutical presentations face, medicinal residues patent medicine oil is dragged for after being coke yellow in inside; again with 320 ℃ of intense fire refining medicine oil; refine to medicine oil meter face and emit white dense smoke, the boiling oil bloom are assembled to pot central authorities, splash in the water till the Cheng Zhu; substrate under the temperature control again; cease fire, when the medicine oil temperature is reduced to 98 ℃, slowly drop into Calamina (forging) powder in 1.3: 1 the ratio of ratio of Calamina (forging) powder and medicine oil; stir evenly; stir to cream and stick with paste when being pale red, become ointment in the impouring cold water, paste at the stand at last; can be warm a little; make it soften into rare flowing soaking paste, radial stand is affixed on mounts on the cloth (or paper), gets product.

The application process of this ointment can adopt for five steps, and the one, the stand is coated with, likeness in form " radial striations, bronze gong limit ", area is generally greater than open sore part infections face; The 2nd, dusting powder drug is used, and can place medicines such as a little is drawn out pus by applying a plaster to the affected part, reducing swelling and alleviating pain, putrefaction removing, granulation promoting, closing in according to lesion nature; The 3rd, patch is changed, and generally changes once every 1-2 days; The 4th, remove patch; The 5th, operation or other are held concurrently mutually and are handled.

By above embodiment, case 1005 examples have been used, wherein swollen (pus) infections 486 examples, ulcer 519 examples, distribute furuncle 150 examples then, furuncle 147 examples, carbuncle 153 examples by disease, send out 48 examples, carbuncle 111 examples, deep abscess 45 examples, multiple abscess 27 examples, maxillofacial sore 24 examples, erysipelas 30 examples, scrofula 54 examples, the tuberculosis of bone and joint 21 examples, sinus tract fistulae 45 examples, necrosis ulcer 3 examples, acute thrombophlebitis ulcer 9 examples, decubital ulcer 6 examples, ecthyma 15 examples, penis subcutaneous nodule 6 examples, epididymal tuberculosis 3 examples, scroal abscess 3 examples, acute orchitis and epididymitis 6 examples, anal abscess 15 examples, scroal abscess type acne 6 examples, eczema of lower limb 9 examples, impetigo 15 examples, herpes zoster 12 examples, lipoma 9 examples, wart carbuncle 3 examples, nodules of the breast 9 examples, Lump in breast 6 examples, suppurative mastitis 3 examples, acute mastitis 18 examples.The course of disease is the shortest one day, and is the longest 10 years.The course of treatment is the shortest 1 day, and is the longest 100 days, average 10 days.By abscess dissipation, ulcer healing and there be not the standard branch of obvious cicatrix for curing, in abscess 486 examples, cure 462 examples, then cure rate is 95%, in ulcer 519 examples, cures 489 examples, cure rate 94%, total cure rate 94.6%.

Claims (2)

1. an infections section zinc-base redness ten thousand is answered ointment, contain the Hibisci Mutabilis floral leaf, Radix Aconiti, Radix Aconiti Kusnezoffii, the Radix Rehmanniae, Radix Ampelopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Corium elephatis, Radix Paeoniae Rubra, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Semen Momordicae, Squama Manis, the Radix Linderae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, Radix Et Rhizoma Rhei, clean Oleum sesami and Calamina (forging) powder, its preceding 20 herbal medicine each component proportionings are: the Hibisci Mutabilis floral leaf accounts for 8-12%, Radix Aconiti, Radix Aconiti Kusnezoffii, the Radix Rehmanniae, Radix Ampelopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Corium elephatis, Radix Paeoniae Rubra, Cortex Cinnamomi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii, Radix Sophorae Flavescentis, Semen Momordicae, Squama Manis, the Radix Linderae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Radix Scrophulariae, the Radix Et Rhizoma Rhei sum accounts for 88-92%, and be equivalent, 20 flavor component gross weights are 1: 7.5～8.5 with the ratio of clean Oleum sesami weight.

2. an infections section zinc-base redness ten thousand is answered the ointment manufacture method, and its manufacturing procedure is followed successively by:

(1) softening process: the preceding 20 flavor prescription medicines that proportioning is good mix, after being processed into coarse powder, putting into container, is that 1: 7.5～8.5 ratio is poured clean Oleum sesami in the ratio of the gross weight of 20 flavor component medicines and clean Oleum sesami weight, in oil, soaked 72-240 hour, till softening with it;

(2) boil medicine oil: with 200～220 ℃ mild and heavy respiration explosive, fried be dark brown to the pharmaceutical presentations face, after inside was coke yellow, dragging for medicinal residues was patent medicine oil;

(3) refining medicine oil: with 300～320 ℃ intense fires refining medicine oil, refine to medicine oil meter face and emit white dense smoke, the boiling oil bloom are assembled to pot central authorities, and it is splashed in the water till the Cheng Zhu;

(4) substrate under the temperature control: after the truce, when the medicine oil temperature is reduced to 95～100 ℃, slowly drop into Calamina (forging) powder, stir while dropping into, Calamina (forging) powder is 1～1.5: 1 with the ratio of medicine weight of oil, stirs to cream and sticks with paste when being pale red, becomes ointment in the impouring cold water.