CN103690639B

CN103690639B - Ointment patch for treating gout

Info

Publication number: CN103690639B
Application number: CN201310706755.9A
Authority: CN
Inventors: 武瑞美
Original assignee: 武瑞美
Current assignee: JINZHOU ZIJIN PHARMACEUTICAL Co.,Ltd.
Priority date: 2013-12-20
Filing date: 2013-12-20
Publication date: 2015-02-18
Anticipated expiration: 2033-12-20
Also published as: CN103690639A

Abstract

The invention discloses an ointment patch for treating gout. The ointment patch is prepared from the following traditional Chinese medicine raw materials in parts by weight: 1-3 parts of garden burnet, 1-3 parts of sageretia theezans root, 1-3 parts of platycladus orientalis, 1-3 parts of masson pine bark, 1-3 parts of herba cepbalanoplosis segeti and 0.25-0.75 part of borneol. The preparation method comprises the following steps: carbonizing the traditional Chinese medicine raw materials except the borneol by stir-frying, respectively grinding the traditional Chinese medicine raw materials subjected to carbonizing by stir-frying and the borneol into powder, uniformly mixing the powder, and allowing the powder to pass through a sieve with the size of 100-120 mesh to prepare powder; adding sesame oil and rosin into a pot, melting by slow fire, putting beewax for melting, adding powdered lubricant and zinc oxide, uniformly stirring, adding the powder, adding the powder under stirring, and keeping the slow fire; and finally, adding silicon azone, uniformly stirring, forming the paste, tiling the paste, and preparing the ointment patch. The ointment patch is convenient to use, safe, low in cost, economical and practical, does not have a toxic or side effect, has a good curative effect on gout, is easily accepted by a patient, is applied to an affected part for treatment by adopting a method for treating an internal illness by external treatment and can exert an obvious curative effect.

Description

A kind of medical ointment plaster being used for the treatment of gout

Technical field

The present invention relates to a kind of external used medicine being used for the treatment of gout, a kind of medical ointment plaster especially wherein.

Background technology

Gout, also known as " hyperuricemia ", is a kind of because of disorders of purine metabolism, makes the synthesis of uric acid increase or discharge and reduces, cause hyperuricemia, thus the disease caused, belong to arthritic one, also known as metabolic arthritis.Due to uric acid excessive concentration in blood of human body, at soft tissue as formed acicular crystal in membrana articulata or tendon, causing body immune system overreaction and the inflammation caused suffering, causing the foreign body inflammatory reaction of tissue.General outbreak position mostly is large female toe joint, ankle joint and knee joint etc.Gouty attack,acute position occur red, swollen, hot, have an intense pain, much more general to show effect midnight, people can be made to wake up with a start from sleep; At the gout initial stage, lower limb are more common in outbreak.According to statistics, gout patients 20% ~ 25% has urate nephropathy, and person is almost 100% nephropathy; Kidney damage comprises gouty nephropathy, acute obstructive nephropathy and lithangiuria.Goat, at any age, can occur, and modal is the middle-aged man of more than 40 years old.

Along with the raising of people's living standard, irrational dietary structure and faster work rhythm, the sickness rate of gout is the trend of cumulative year after year.But up to now, clinical treatment gout first-selection or colchicine, its dose therapeutically effective easily causes serious gastrointestinal reaction.

Therefore, a kind of efficient, convenient, bland gout medicine for external use of exploitation, especially medical ointment plaster has the urgency of clinical demand.Chinese medicine external treatment gout is effective, obtains clinical affirmative, and medicine source is abundant, side effect is little.Therefore, screen effective Chinese medicine, form new exterior-applied formulation in conjunction with modern novel adjuvant, will wide potential applicability in clinical practice be had.

Summary of the invention

Task of the present invention is to provide a kind of medical ointment plaster being used for the treatment of gout.

Being used for the treatment of a medical ointment plaster for gout, is be made up of the raw material of Chinese medicine by following parts by weight:

Radix Sanguisorbae 1 ~ 3 part, Sageretia theezans root 1 ~ 3 part, Cacumen Platycladi 1 ~ 3 part, horse hair Cortex Pini Massonianae 1 ~ 3 part, Herba Cirsii 1 ~ 3 part, Borneolum Syntheticum 0.25 ~ 0.75 part.

The above-mentioned medical ointment plaster being used for the treatment of gout takes following step to prepare:

1. by above-mentioned Radix Sanguisorbae, Sageretia theezans root, Cacumen Platycladi, horse hair Cortex Pini Massonianae, Herba Cirsii parch to black; After raw material of Chinese medicine after parch to black and Borneolum Syntheticum are ground to form powdery respectively, mix homogeneously is crossed 100 ~ 120 mesh sieves and is made powder, or after grinding to form powdery after being mixed with Borneolum Syntheticum by the raw material of Chinese medicine after parch to black, mistake 100 ~ 120 mesh sieves make powder;

2. by Oleum sesami 1 ~ 2 part and Colophonium 1 ~ 2 part of injection pot, slow fire melts, put into the fusing of 1 ~ 2 part, Cera Flava, then put into powdered lubricant 1 ~ 2 part and zinc oxide 0.1 ~ 0.5 part, stir, then add above-mentioned powder, limit edged stirs, keep slow fire, finally inject silicon azone 0.1 ~ 0.5 part and stir, be brewed into paste;

3. spread out cream, make medical ointment plaster.

Pharmacology analysis:

Radix Sanguisorbae in the present invention, another name claims Fructus Cucumidis sativi cus-cus, mountain Radix Fici tikouae, whip Fructus Jujubae beard etc., records, have cooling blood for hemostasis, effect of astringing to arrest diarrhea according to China's pharmacopeia.Sageretia theezans (Sageretia theezans), according to the record of " Chinese Plants will " (Science Press, 1982), is Rhamnaceae, rattan shape or upright shrub; Sprig tool stings, alternate or near to life, and brown, by pubescence; Originate in Yangtze River in China basin and southeastern coast each province, also there are distribution in Japan and India, are subtropical zone preferential species of tree; Sageretia theezans root, has the effects such as lowering the adverse-rising QI to resolve phlegm, wind-damp dispelling, benefit muscles and bones, can treat the diseases such as scabies, edema, the arthroncus of knee.Cacumen Platycladi, another name claims Cacumen Platycladi (Cacumen Biotae), Cong Baiye, arborvitae, flat pine etc., has removing heat from blood, hemostasis, wind-damp dispelling, loose effect swollen and ache.Horse hair Cortex Pini Massonianae, the i.e. dry bark of Pinus massoniana Lamb, have wind-damp dispelling, blood circulation promoting and blood stasis dispelling, pain relieving, hemostasis, loose effect swollen and ache.Herba Cirsii, another name claims field thistle, luxuriant dish, shepherd's purse shepherd's purse hair etc., has cooling blood for hemostasis, the effect of strongly fragrant detumescence of dispelling.Borneolum Syntheticum, has effect of refreshment of having one's ideas straightened out, loose stagnated fire, reducing swelling and alleviating pain.

Medical ointment plaster of the present invention is easy to use, safe, have no side effect, good curative effect is had to gout, with low cost, economical and practical, patient is acceptant, adopts the method for inner disease outer treat, be attached to affected part to treat, absorb by skin, make topical remedy's valid density be significantly higher than haemoconcentration, thus play comparatively significant curative effect.

Detailed description of the invention

Embodiment 1

Take Radix Sanguisorbae 100g, Sageretia theezans root 100g, Cacumen Platycladi 100g, horse hair Cortex Pini Massonianae 100g, Herba Cirsii 100g, Borneolum Syntheticum 25g.

By above-mentioned Radix Sanguisorbae, Sageretia theezans root, Cacumen Platycladi, horse hair Cortex Pini Massonianae, Herba Cirsii parch to black; After raw material of Chinese medicine after parch to black and Borneolum Syntheticum are ground to form powdery respectively, mix homogeneously is crossed 100 mesh sieves and is made powder.

Oleum sesami 100g and Colophonium 100g is injected pot, and slow fire melts, and puts into Cera Flava 100g and melts, then put into powdered lubricant 100g and zinc oxide 10g, stir, then add above-mentioned powder, limit edged stirs, keep slow fire, finally inject silicon azone 10g and stir, be brewed into paste;

Stand cream, makes medical ointment plaster.

Embodiment 2

Take Radix Sanguisorbae 200g, Sageretia theezans root 200g, Cacumen Platycladi 200g, horse hair Cortex Pini Massonianae 200g, Herba Cirsii 200g, Borneolum Syntheticum 50g.

By above-mentioned Radix Sanguisorbae, Sageretia theezans root, Cacumen Platycladi, horse hair Cortex Pini Massonianae, Herba Cirsii parch to black; After raw material of Chinese medicine after parch to black and Borneolum Syntheticum are ground to form powdery respectively, mix homogeneously is crossed 110 mesh sieves and is made powder.

Oleum sesami 150g and Colophonium 150g is injected pot, and slow fire melts, and puts into Cera Flava 150g and melts, then put into powdered lubricant 150g and zinc oxide 15g part, stir, then add above-mentioned powder, limit edged stirs, keep slow fire, finally inject silicon azone 15g part and stir, be brewed into paste;

Stand cream, makes medical ointment plaster.

Embodiment 3

Take Radix Sanguisorbae 300g, Sageretia theezans root 300g, Cacumen Platycladi 300g, horse hair Cortex Pini Massonianae 300g, Herba Cirsii 300g, Borneolum Syntheticum 75g.

By above-mentioned Radix Sanguisorbae, Sageretia theezans root, Cacumen Platycladi, horse hair Cortex Pini Massonianae, Herba Cirsii parch to black; Cross 120 mesh sieves after grinding to form powdery after being mixed with Borneolum Syntheticum by raw material of Chinese medicine after parch to black and make powder.

Oleum sesami 200g and Colophonium 200g is injected pot, and slow fire melts, and puts into Cera Flava 200g and melts, then put into powdered lubricant 200g and zinc oxide 50g, stir, then add above-mentioned powder, limit edged stirs, keep slow fire, finally inject silicon azone 50g and stir, be brewed into paste;

Stand cream, makes medical ointment plaster.

Embodiment 4

Take Radix Sanguisorbae 100g, Sageretia theezans root 200g, Cacumen Platycladi 100g, horse hair Cortex Pini Massonianae 200g, Herba Cirsii 100g, Borneolum Syntheticum 25g.

Oleum sesami 100g and Colophonium 100g is injected pot, and slow fire melts, and puts into Cera Flava 100g and melts, then put into powdered lubricant 100g and zinc oxide 25g, stir, then add above-mentioned powder, limit edged stirs, keep slow fire, finally inject silicon azone 25g and stir, be brewed into paste;

Stand cream, makes medical ointment plaster.

Embodiment 5

Take Radix Sanguisorbae 300g, Sageretia theezans root 100g, Cacumen Platycladi 300g, horse hair Cortex Pini Massonianae 100g, Herba Cirsii 200g, Borneolum Syntheticum 75g.

Oleum sesami 150g and Colophonium 150g is injected pot, and slow fire melts, and puts into Cera Flava 150g and melts, then put into powdered lubricant 150g and zinc oxide 25g, stir, then add above-mentioned powder, limit edged stirs, keep slow fire, finally inject silicon azone 25g and stir, be brewed into paste;

Stand cream, makes medical ointment plaster.

Clinical data:

The present invention for traditional Chinese medical science gout, through 100 routine clinical observations.Select tcm diagnosis gout to be standard: patient has hyperuricemia, often in midnight joint have an intense pain, joint is red, swollen, hot at ordinary times, bitterly, limitation of activity, articular cavity has hydrops, occurs that tophus precipitates.As there is above-mentioned symptom, can make a definite diagnosis.In the case making a definite diagnosis observation, male accounts for 70 examples, and women accounts for 30 examples, and without other serious diseases, the age, the mean age was 47.5 years old between 40 ~ 65 years old.

Efficacy determination:

1. effective: body constitution strengthens, with it energetically; Hyperuricemia is controlled, and red, swollen, hot, the pain in joint are obviously alleviated; Hydrarthrosis reduces.

2. effective: body constitution strengthens, with it energetically; Red, swollen, hot, the pain in joint alleviate to some extent.

3. invalid: disease is unchanged.

During clinical trial, stop using other drug and health nutrient.

Therapeutic Method: by above-described embodiment gained plaster, be affixed on affected part, changes for one day one; Within 7th, be a course for the treatment of, subsides in a day; Sick light patient needs 1 ~ 2 course for the treatment of, and patient with severe symptoms needs 3 courses for the treatment of.

Therapeutic effect: curing number is 52 examples, and significant figure is 40 examples, and invalid number is 8 examples, and total effective rate reaches 92%.There are no toxic and side effects in therapeutic process, also there is good curative effect to obstinate patient.

For further illustrating therapeutic effect, now enumerate model case as follows:

Patient 1: certain man, 42 years old, suffers from gout 1 year, and partial joint is red, swollen, bitterly.Treat with medical ointment plaster of the present invention, every day one pastes, and above symptom is alleviated for 10 days, eliminates after two courses for the treatment of.

Patient 2: certain female, 50 years old, suffer from gout 4 years, brothers' cold type of pain, articular pain.Treat with medical ointment plaster of the present invention, every day one pastes, and above symptom is alleviated for 15 days, and three courses for the treatment of eliminate.

Patient 3: certain man, 62 years old, suffer from gout 8 years, whole body membra arthralgia, moving difficulty.Treat with medical ointment plaster of the present invention, every day one pastes, and above symptom is alleviated three courses for the treatment of.

The relevant technologies content do not addressed in aforesaid way is taked or uses for reference prior art to realize.

It should be noted that, under the instruction of this description, those skilled in the art can also make such or such easy variation pattern, such as equivalent way, or obvious mode of texturing.Above-mentioned variation pattern all should within protection scope of the present invention.

Claims

1. be used for the treatment of a medical ointment plaster for gout, it is characterized in that being made up of the raw material of Chinese medicine by following parts by weight:

Radix Sanguisorbae 1 ~ 3 part, Sageretia theezans root 1 ~ 3 part, Cacumen Platycladi 1 ~ 3 part, horse hair Cortex Pini Massonianae 1 ~ 3 part, Herba Cirsii 1 ~ 3 part, Borneolum Syntheticum 0.25 ~ 0.75 part;

By above-mentioned Radix Sanguisorbae, Sageretia theezans root, Cacumen Platycladi, horse hair Cortex Pini Massonianae, Herba Cirsii parch to black; After raw material of Chinese medicine after parch to black and Borneolum Syntheticum are ground to form powdery respectively, mix homogeneously is crossed 100 ~ 120 mesh sieves and is made powder, or after grinding to form powdery after being mixed with Borneolum Syntheticum by the raw material of Chinese medicine after parch to black, mistake 100 ~ 120 mesh sieves make powder;

By Oleum sesami 1 ~ 2 part and Colophonium 1 ~ 2 part of injection pot, slow fire melts, put into the fusing of 1 ~ 2 part, Cera Flava, then put into powdered lubricant 1 ~ 2 part and zinc oxide 0.1 ~ 0.5 part, stir, then add above-mentioned powder, limit edged stirs, keep slow fire, finally inject silicon azone 0.1 ~ 0.5 part and stir, be brewed into paste;

Stand cream, makes medical ointment plaster.