CN111329907A - Common turnip composition with anti-hypoxia function and preparation method and application thereof - Google Patents
Common turnip composition with anti-hypoxia function and preparation method and application thereof Download PDFInfo
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- CN111329907A CN111329907A CN202010152239.6A CN202010152239A CN111329907A CN 111329907 A CN111329907 A CN 111329907A CN 202010152239 A CN202010152239 A CN 202010152239A CN 111329907 A CN111329907 A CN 111329907A
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- hypoxia
- ethanol
- sea buckthorn
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a common turnip composition with an anti-hypoxia function, a preparation method and application thereof. The invention has the advantages of unique and simple formula, high extraction rate of effective components, obvious function, no toxic or side effect, quick absorption, convenient taking and the like, integrates the functions of resisting anoxia and enhancing immunity, and can be safely taken for a long time.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a yuenkanin composition with an anti-hypoxia function, and a preparation method and application thereof.
Background
High altitude hypoxic environment, respiratory diseases (such as pulmonary heart disease, pulmonary infection) and cardiovascular diseases (heart failure, right-left shunt of congenital heart disease) can all cause hypoxia, the lower the blood oxygen concentration, the more severe the hypoxia, and severe hypoxia can affect the cardiovascular system.
Acute hypoxia is usually more acute. The mild patients may have dysphoria, euphoria, agitation, slow reaction, poor comprehension and orientation, rapid respiration and heart rate increase, elevated blood pressure, and tendon hyperreflexia. Serious patients may have varying degrees of disturbance of consciousness, generalized or localized seizures.
Chronic anoxia has symptoms of dizziness, headache, tinnitus, dim eyesight, weakness of limbs, palpitation, short breath, shortness of breath, and rapid heartbeat. Severe, can lead to respiratory failure and even life-threatening.
Either acute or chronic hypoxia can cause dysfunction or dysfunction of body organs, and serious can be life threatening. Therefore, the anti-hypoxia peptide has important significance.
At present, acute hypoxia needs to be sent to a hospital in time for treatment by high pressure oxygen and the like, and chronic hypoxia needs to be treated by equipment such as a breathing machine and the like, so that the use is inconvenient. The existing medicines are mostly suitable for resisting altitude stress, namely symptoms caused by low-pressure hypoxia, and the medicines taken under normal pressure can excite the human body, cause discomfort and side effects, and are even not suitable for long-term taking by chronic hypoxia patients.
Disclosure of Invention
The invention aims to: aiming at the defects in the prior art, the yuenkanin composition with the anti-hypoxia function, the preparation method and the application thereof are provided, the yuenkanin composition can effectively resist hypoxia, can enhance immunity and can be safely taken for a long time.
The technical scheme adopted by the invention is as follows:
a common turnip composition with an anti-hypoxia function comprises the following raw materials in parts by weight:
5-15 parts of common turnip, 20-40 parts of potentilla anserina and 3-9 parts of sea buckthorn.
Further, the feed comprises the following raw materials in parts by weight:
10 parts of common turnip, 30 parts of potentilla anserina and 6 parts of sea buckthorn.
The Genkwa root (Brassica rapa L.) has rich nutrition, and has pure white, succulent, tender, light and slightly sweet taste, and slightly pungent taste, and contains abundant vitamin A, vitamin B, vitamin C, various saccharides and minerals, p-coumaric acid, caffeic acid, ferulic acid, gentisic acid, phenylpyruvic acid, and p-channelBenzoic acid, and the like. Every hundred grams of fresh product contains 1.5g of protein, 0.1g of fat, 6.3g of carbohydrate, 0.5g of dietary fiber and VA38mg、VC25mg of vitamin B10.07mg of vitamin B20.04mg, phosphorus 31mg, iron 0.5mg, calcium 41mg, and amino acids and other vitamins essential to human body. The lilac daphne root has the effects of clearing away heat and toxic materials, nourishing, enhancing immunity, resisting mutation, radiation, fatigue, aging, anoxia and the like. The common turnip contains more sugar, and people of Tibetan often use the common turnip to relieve a series of altitude anoxia reactions such as dizziness, dim eyesight, palpitation and the like.
Potentilla anserina is the underground root tuber of Potentilla anserine L (Potentilla anserine L.) of Potentilla of Rosaceae, also called herba Herminii, and is commonly used as the medicine in Qinghai plateau drug atlas. Researches show that the potentilla anserina can obviously improve the utilization rate of the organism to oxygen and has obvious anti-hypoxia effect. The ethanol extract of radix Potentillae Anserinae can prolong survival rate of mouse under reduced pressure and anoxia condition, prolong survival time of mouse under specific myocardial anoxia condition caused by asphyxia anoxia and isoproterenol, and inhibit oxidation of oxygen free radicals on erythrocyte. Potentilla anserine polysaccharide is an important active ingredient of potentilla anserine, which has been found to have the ability to enhance the immunity of mice.
Hippophae rhamnoides (Hippophae rhamnoides), Elaeagnaceae, shrubs or trees, also known as Acetoceros tamarinowii, Nitraria, Oxytropis procumbens, Ottypodium, Kittypu, and Kighui. Seabuckthorn contains more than one hundred compounds, which comprise amino acids, vitamins, trace elements, tocopherols, carotenoids, polyphenols, flavones and other active substances such as fatty acids beneficial to the body, which are necessary for the human body but cannot be synthesized by the human body. The sea-buckthorn has obvious functions in protecting cardiovascular and cerebrovascular systems, treating gastrointestinal diseases, protecting liver, resisting tumor, resisting oxidation and regulating immunity.
The invention takes the plant juice and the extract of traditional Tibetan medicine and food as main components, fully exerts the regulation effect of the plant raw materials on the physiological function of a human body through the reasonable proportioning of the daphne genkwa root, the potentilla anserina and the sea buckthorn, has the synergistic effect on the functions of resisting anoxia, enhancing immunity and the like of the flavone and the polyphenol of the mixed extract of various saccharides of the daphne genkwa root and the potentilla anserina and the sea buckthorn, can generate symptoms of dizziness, dim eyesight and the like due to insufficient oxygen supply of brain during anoxia, can supplement energy for the human body in time by sugar intake at the moment, can promote the brain to operate and relieve the symptoms of dizziness, palpitation and the like, can improve the immunity of the human body by enhancing the activity of immunocytes and accelerating the oxygen supply to the brain to relieve anoxia, therefore, the components of the invention are mutually cooperated to promote to obtain good effect, and the invention has no toxic side effect and can be eaten for a long time; the extract obtained by mixing and extracting the potentilla anserina and the sea buckthorn effectively improves the concentration of effective components, so that the extract obtains good anti-hypoxia effect, and the extract is further verified by an anti-hypoxia experiment, and simultaneously neutralizes the cold and heat properties of the extract, so that the applicable population is expanded, and the long-term eating is facilitated.
The preparation method of the radix genkwa composition with the anti-hypoxia function comprises the steps of uniformly mixing the radix genkwa with the mixed extract of the potentilla anserina and the sea buckthorn to obtain the radix genkwa composition;
the radix Genkwa is obtained by squeezing radix Genkwa, centrifuging and filtering;
the mixed extract of potentilla anserina and sea buckthorn is prepared by the following operations: mixing radix Potentillae Anserinae and fructus Hippophae, adding 70 vt% ethanol 4-10 times of the total weight of the mixture, soaking for 20-40min, heating under reflux, and extracting for 2 times.
Further, the specific preparation steps of the mixed extract of the potentilla anserina and the sea buckthorn are as follows:
mixing radix Potentillae Anserinae and fructus Hippophae, adding 5-10 times of 70 vt% ethanol, soaking for 30min, heating to 75-85 deg.C, reflux extracting for 1-3 hr, filtering, and rotary steaming the filtrate until no alcohol smell exists; adding 70 vt% ethanol 4-6 times of the total weight of radix Potentillae Anserinae and fructus Hippophae into the residue, heating to 75-85 deg.C, reflux extracting for 0.5-1.5 hr, filtering, rotary steaming the filtrate until no ethanol smell exists, mixing filtrates, and concentrating.
The application of the yuenkanin composition with the anti-hypoxia function in preparing medicines, health-care products and foods.
Further, the method specifically comprises the following steps: the composition can be made into granule, capsule, tablet, pill, oral liquid, plant beverage, solid beverage or teabag.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. according to the invention, the Tibetan medicinal and edible dual-purpose coriander raw juice and the potentilla anserina and sea backthern mixed extract are used as main components, and the regulation effect of plant raw materials on the physiological function of a human body is fully exerted through reasonable proportioning of the coriander, the potentilla anserina and the sea backthern and mixed extraction of the potentilla anserina and the sea backthern, so that the Tibetan medicinal and edible dual-purpose natural juice has no toxic or side effect and can be;
2. experiments prove that the mixed extract of the common turnip, the silverweed cinquefoil root and the sea backthern has a synergistic effect in the aspects of functions of resisting anoxia, enhancing immunity and the like, compared with the raw juice of the silverweed cinquefoil root and the sea backthern and the extract which is separately extracted from the silverweed cinquefoil root and the sea backthern, the extract which is obtained by mixing and extracting the silverweed cinquefoil root and the sea backthern effectively improves the concentration of effective components, so that the extract shows good effects in normal-pressure anoxia resistant time and acute cerebral ischemia anoxia experiments, and meanwhile, the extraction mode of mixing and extracting the silverweed cinquefoil root and the sea backthern neutralizes the cold and heat properties, thereby expanding applicable people, being beneficial to;
3. the composition has the advantages of simple components, unique formula, scientific dosage proportion, high extraction rate of effective components, remarkable function, no toxic or side effect, quick absorption, convenient taking and easy preparation, and can be prepared into various medicines, health-care products or foods by using a method acceptable in production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.
Thus, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
It is noted that relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The yuenkanin composition with the anti-hypoxia function provided by the preferred embodiment of the invention comprises the following components in parts by weight:
10 parts of common turnip, 30 parts of potentilla anserina and 6 parts of sea buckthorn;
is prepared by uniformly mixing the mixed extracts of radix genkwa, radix potentillae anserinae and sea buckthorn;
the radix Genkwa is obtained by squeezing radix Genkwa, centrifuging and filtering;
the mixed extract of potentilla anserina and sea buckthorn is prepared by the following operations: mixing radix Potentillae Anserinae and fructus Hippophae, adding 70 vt% ethanol 8 times of the total weight of the mixture, soaking for 30min, heating to 80 deg.C, reflux extracting for 2 hr, filtering, and rotary steaming the filtrate until no alcohol smell exists; adding 70 vt% ethanol 5 times of the total weight of radix Potentillae Anserinae and fructus Hippophae into the residue, heating to 80 deg.C, reflux extracting for 1h, filtering, rotary steaming the filtrate until no ethanol smell exists, mixing filtrates, and concentrating.
Example 2
The yuenkanin composition with the anti-hypoxia function provided by the preferred embodiment of the invention comprises the following components in parts by weight:
5 parts of common turnip, 20 parts of potentilla anserina and 3 parts of sea buckthorn;
is prepared by uniformly mixing the mixed extracts of radix genkwa, radix potentillae anserinae and sea buckthorn;
the radix Genkwa is obtained by squeezing radix Genkwa, centrifuging and filtering;
the mixed extract of potentilla anserina and sea buckthorn is prepared by the following operations: mixing radix Potentillae Anserinae and fructus Hippophae, adding 70 vt% ethanol 5 times of the total weight of the mixture, soaking for 30min, heating to 80 deg.C, reflux extracting for 2 hr, filtering, and rotary steaming the filtrate until no alcohol smell exists; adding 70 vt% ethanol 4 times of the total weight of radix Potentillae Anserinae and fructus Hippophae into the residue, heating to 80 deg.C, reflux extracting for 1h, filtering, rotary steaming the filtrate until no ethanol smell exists, mixing filtrates, and concentrating.
Example 3
The yuenkanin composition with the anti-hypoxia function provided by the preferred embodiment of the invention comprises the following components in parts by weight:
15 parts of common turnip, 40 parts of potentilla anserina and 9 parts of sea buckthorn;
is prepared by uniformly mixing the mixed extracts of radix genkwa, radix potentillae anserinae and sea buckthorn;
the radix Genkwa is obtained by squeezing radix Genkwa, centrifuging and filtering;
the mixed extract of potentilla anserina and sea buckthorn is prepared by the following operations: mixing radix Potentillae Anserinae and fructus Hippophae, adding 10 times of 70 vt% ethanol, soaking for 30min, heating to 80 deg.C, reflux extracting for 2 hr, filtering, and rotary steaming the filtrate until no alcohol smell exists; adding 70 vt% ethanol 6 times of the total weight of radix Potentillae Anserinae and fructus Hippophae into the residue, heating to 80 deg.C, reflux extracting for 1h, filtering, rotary steaming the filtrate until no ethanol smell exists, mixing filtrates, and concentrating.
Example 4
The yuenkanin composition with the anti-hypoxia function provided by the preferred embodiment of the invention comprises the following components in parts by weight:
7 parts of common turnip, 25 parts of potentilla anserina and 5 parts of sea buckthorn;
is prepared by uniformly mixing the mixed extracts of radix genkwa, radix potentillae anserinae and sea buckthorn;
the radix Genkwa is obtained by squeezing radix Genkwa, centrifuging and filtering;
the mixed extract of potentilla anserina and sea buckthorn is prepared by the following operations: mixing radix Potentillae Anserinae and fructus Hippophae, adding 7 times of 70 vt% ethanol, soaking for 30min, heating to 80 deg.C, reflux extracting for 1h, filtering, and rotary steaming the filtrate until no alcohol smell exists; adding 70 vt% ethanol 5 times of the total weight of radix Potentillae Anserinae and fructus Hippophae into the residue, heating to 80 deg.C, reflux extracting for 0.5h, filtering, rotary steaming the filtrate until no alcohol smell exists, mixing filtrates, and concentrating.
Example 5
The yuenkanin composition with the anti-hypoxia function provided by the preferred embodiment of the invention comprises the following components in parts by weight:
12 parts of common turnip, 35 parts of potentilla anserina and 8 parts of sea buckthorn;
is prepared by uniformly mixing the mixed extracts of radix genkwa, radix potentillae anserinae and sea buckthorn;
the radix Genkwa is obtained by squeezing radix Genkwa, centrifuging and filtering;
the mixed extract of potentilla anserina and sea buckthorn is prepared by the following operations: mixing radix Potentillae Anserinae and fructus Hippophae, adding 9 times of 70 vt% ethanol, soaking for 30min, heating to 80 deg.C, reflux extracting for 2 hr, filtering, and rotary steaming the filtrate until no alcohol smell exists; adding 70 vt% ethanol 6 times of the total weight of radix Potentillae Anserinae and fructus Hippophae into the residue, heating to 80 deg.C, reflux extracting for 1.5 hr, filtering, rotary steaming the filtrate until no alcohol smell exists, mixing filtrates, and concentrating.
Examples of the experiments
Experimental groups: compositions prepared in example 1 were used in the low (0.05mL/10g), medium (0.2mL/10g), and high (0.5mL/10g) dose groups, respectively;
blank group: pure water;
control group 1: rhodiola sachets available on the market;
control group 2: the preparation method is the same as that of the embodiment 1, only the potentilla anserina and the sea buckthorn are respectively extracted and then mixed;
control group 3: the mixture ratio is the same as that of example 1, and the mixture of yuenkanin, potentilla anserine and sea-buckthorn raw juice is adopted.
100 Kunming white mice with half male and female bodies, 18-22g of body weight and clean grade are bred for 5 days conventionally, after the mice are adapted to the environment, except a blank group, the mice are irrigated with corresponding medicaments by intragastric administration every day, the dosage is 0.2mL/10g, and the mice are continuously bred for 7 days.
(1) Experiment of oxygen deficiency resistance under normal pressure
According to the functional test method for improving anoxia endurance in the functional evaluation test method of health food test and evaluation technical Specification (2003 edition), after the last 1 gastric lavage for administration for 60min, each group of mice is placed in 250mL ground bottles sealed by Vaseline (10 g of soda lime is placed in the bottles in advance to absorb carbon dioxide and water), 1 mouse is placed in each bottle, the time is measured immediately after the bottle is covered, and the survival time of the mice is observed and recorded by taking the last breathing time of the mice as an index.
(2) Acute cerebral ischemia and hypoxia experiment
After the administration for 60min by gavage, each group of mice broke their heads from the neck, immediately timing, and recording the time from the head breaking to the mouth opening wheezing stopping, namely the time of acute cerebral ischemic anoxia.
Statistical processing was performed using SPSS19.0 statistical software, the results of the analysis are expressed in x + -s, the comparison between groups was performed using t-test, and differences were considered statistically significant when P < 0.05.
The results of the experiments are shown in table 1 below. Compared with the blank group, the acute cerebral ischemia and hypoxia time of the control group 1 is obviously increased, has extremely obvious difference (P <0.01), and the normal pressure hypoxia tolerance time is only slightly increased; the normal pressure hypoxia tolerance time of the middle and high dose groups in the experimental group has significant difference (P <0.05), and the acute cerebral ischemia hypoxia time has significant difference (P < 0.01); the time of the normal pressure hypoxia tolerance of the control group 2 is between that of the control group 1 and that of the experimental group, while the time of the acute cerebral ischemia hypoxia is between that of the control group 1 and that of the medium-high dose group of the experimental group, and the time is significantly different (P < 0.05); the time of normal pressure hypoxia tolerance and the time of acute cerebral ischemia hypoxia of the control group 3 are slightly increased.
The result shows that the invention can obviously increase the mouse normal pressure hypoxia tolerance time and the acute cerebral ischemia hypoxia tolerance time, and compared with the commercially available medicine, the invention has the advantages that the normal pressure hypoxia tolerance time is increased, and the normal pressure hypoxia tolerance time and the acute cerebral ischemia hypoxia tolerance time of the original juice are greatly improved, which shows that the mixed extraction of the potentilla anserina and the sea buckthorn has the synergistic enhancement effect, so that the composition of the invention has the good anti-hypoxia function.
TABLE 1 results of antihypoxic experiments
Note: in comparison to the blank set, the data is,*represents P<0.05, significant difference;**represents P<0.01, there was a very significant difference.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (6)
1. A common turnip composition with an anti-hypoxia function is characterized by comprising the following raw materials in parts by weight:
5-15 parts of common turnip, 20-40 parts of potentilla anserina and 3-9 parts of sea buckthorn.
2. The yuenkanin composition with the anti-hypoxia function according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
10 parts of common turnip, 30 parts of potentilla anserina and 6 parts of sea buckthorn.
3. The method for preparing the yuenkanin composition with the anti-hypoxia function according to claim 1 or 2, which is characterized in that: mixing radix Genkwa with mixed extract of radix Potentillae Anserinae and fructus Hippophae uniformly to obtain;
the common turnip is obtained by squeezing and centrifuging the common turnip root and filtering;
the mixed extract of the potentilla anserina and the sea buckthorn is prepared by the following operations: mixing radix Potentillae Anserinae and fructus Hippophae, adding 70 vt% ethanol 4-10 times of the total weight of the mixture, soaking for 20-40min, heating under reflux, and extracting for 2 times.
4. The method for preparing the yuenkanin composition with the anti-hypoxia function according to claim 3, wherein the mixed extract of the potentilla anserina and the sea buckthorn is prepared by the following steps:
mixing radix Potentillae Anserinae and fructus Hippophae, adding 5-10 times of 70 vt% ethanol, soaking for 30min, heating to 75-85 deg.C, reflux extracting for 1-3 hr, filtering, and rotary steaming the filtrate until no alcohol smell exists; adding 70 vt% ethanol 4-6 times of the total weight of radix Potentillae Anserinae and fructus Hippophae into the residue, heating to 75-85 deg.C, reflux extracting for 0.5-1.5 hr, filtering, rotary steaming the filtrate until no ethanol smell exists, mixing filtrates, and concentrating.
5. Use of the yuenkanin composition with anti-hypoxia function according to claim 1 or 2 in preparation of medicines, health products and foods.
6. The use according to claim 5, characterized in that it is in particular: the composition can be made into granule, capsule, tablet, pill, oral liquid, plant beverage, solid beverage or teabag.
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| CN113827631A (en) * | 2021-11-17 | 2021-12-24 | 西藏藏医药大学 | Tibetan medicine compound for preventing and treating acute altitude stress and health-care product thereof |
| CN114306481A (en) * | 2022-01-18 | 2022-04-12 | 陕西克林维尔信息科技有限公司 | Traditional Chinese medicine composition for resisting altitude stress and preparation method thereof |
| CN115088765A (en) * | 2022-06-17 | 2022-09-23 | 青海省轻工业研究所有限责任公司 | Common turnip and sea buckthorn fruit milk and preparation method thereof |
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