CN111328331A - 用于将肠道中的抗生素抗性细菌去定植的组合物和方法 - Google Patents

用于将肠道中的抗生素抗性细菌去定植的组合物和方法 Download PDF

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Publication number
CN111328331A
CN111328331A CN201880064759.2A CN201880064759A CN111328331A CN 111328331 A CN111328331 A CN 111328331A CN 201880064759 A CN201880064759 A CN 201880064759A CN 111328331 A CN111328331 A CN 111328331A
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bacterial
pharmaceutical composition
bacterial strains
listed
rrna
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Pending
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CN201880064759.2A
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English (en)
Chinese (zh)
Inventor
M·圣地亚哥
K·勒洛夫斯
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Finch Therapeutics Inc
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Finch Therapeutics Inc
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Publication of CN111328331A publication Critical patent/CN111328331A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201880064759.2A 2017-08-07 2018-08-07 用于将肠道中的抗生素抗性细菌去定植的组合物和方法 Pending CN111328331A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762542033P 2017-08-07 2017-08-07
US62/542,033 2017-08-07
PCT/US2018/045592 WO2019032572A1 (en) 2017-08-07 2018-08-07 COMPOSITIONS AND METHODS FOR DECOLONIZING ANTIBIOTIC-RESISTANT BACTERIA IN INTESTINES

Publications (1)

Publication Number Publication Date
CN111328331A true CN111328331A (zh) 2020-06-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880064759.2A Pending CN111328331A (zh) 2017-08-07 2018-08-07 用于将肠道中的抗生素抗性细菌去定植的组合物和方法

Country Status (8)

Country Link
US (2) US20200093870A1 (enExample)
EP (1) EP3665181A4 (enExample)
JP (1) JP2020530493A (enExample)
KR (1) KR20200037851A (enExample)
CN (1) CN111328331A (enExample)
AU (1) AU2018313765A1 (enExample)
CA (1) CA3072029A1 (enExample)
WO (1) WO2019032572A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115812100A (zh) * 2020-09-01 2023-03-17 国立大学法人东北大学 乳汁中的IgA抗体含量的增加剂

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WO2011151941A1 (ja) 2010-06-04 2011-12-08 国立大学法人東京大学 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物
JP6306507B2 (ja) 2011-12-01 2018-04-18 国立大学法人 東京大学 制御性ｔ細胞の増殖または集積を誘導するヒト由来細菌
WO2019032573A1 (en) 2017-08-07 2019-02-14 Finch Therapeutics, Inc. COMPOSITIONS AND METHODS FOR MAINTAINING AND RESTORING A HEALTHY INTESTINAL BARRIER
WO2019079629A1 (en) * 2017-10-18 2019-04-25 Ascus Biosciences, Inc. IMPROVING POULTRY PRODUCTION BY ADMINISTERING A SYNTHETIC BIO-ASSEMBLY OF MICROBES OR PURIFIED STEM THEREFOR
CN113038957A (zh) 2018-04-10 2021-06-25 谢尔塔治疗公司 微生物群
WO2020132098A1 (en) * 2018-12-19 2020-06-25 Healthy Cow Corporation Ready-to-use probiotic compositions and uses thereof
BR112022000875A2 (pt) 2019-07-19 2022-03-29 Finch Therapeutics Holdings Llc Métodos e produtos para tratamento de distúrbios gastrointestinais
EP4021467A4 (en) 2019-08-28 2023-09-13 Xbiome Inc. COMPOSITIONS CONTAINING BACTERIAL SPECIES AND ASSOCIATED METHODS
AU2020354581A1 (en) 2019-09-24 2022-03-03 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
KR20220108765A (ko) 2019-10-07 2022-08-03 시올타 테라퓨틱스, 인크. 치료용 약학 조성물
GB201915144D0 (en) * 2019-10-18 2019-12-04 Multigerm Uk Entpr Ltd Method of promoting SCFA production by gut microbiota
KR20220101637A (ko) * 2019-10-18 2022-07-19 핀치 테라퓨틱스 홀딩스 엘엘씨 박테리아 대사산물을 대상체에 전달하기 위한 조성물 및 방법
EP3838281A1 (en) * 2019-12-20 2021-06-23 4D Pharma Research Limited Compositions comprising bacterial strains
WO2021231804A2 (en) * 2020-05-13 2021-11-18 President And Fellows Of Harvard College Methods and compositions for suppressing inflammation induced by gut microbes
GB202007452D0 (en) * 2020-05-19 2020-07-01 Microbiotica Ltd Threrapeutic bacterial composition
MX2023001743A (es) 2020-08-14 2023-04-21 Prolacta Bioscience Inc Composiciones de oligosacáridos de la leche humana para usarse con bacterioterapias.
EP4223868A4 (en) * 2020-09-30 2025-02-12 National Cancer Center ENHANCEMENT OF THE ANTITUMOR EFFECT OF AN IMMUNE CHECKPOINT INHIBITOR BY ADMINISTRATION OF AN INTESTINAL RUMINOCOCCACEAE BACTERIUM
JP2023550652A (ja) * 2020-11-25 2023-12-04 セレス セラピューティクス インコーポレイテッド 移植片対宿主病を処置するための設計された細菌組成物
US20230149483A1 (en) * 2021-11-12 2023-05-18 Iowa State University Research Foundation, Inc. Short-chain fatty acid use to mitigate antimicrobial resistance and virulence gene transfer in the gut
EP4442264A4 (en) * 2021-12-02 2025-07-16 Univ Tohoku THERAPEUTIC AGENT FOR DIARRHEA AND METHOD FOR TREATING BOVINE DIARRHEA
KR102780901B1 (ko) * 2022-11-09 2025-03-17 주식회사 굿바이옴텍 베타-락탐계 항생제 내성 유전자 ｂｌａＣＴＸ－Ｍ－２２９ 및 퀴놀론계 항생제 내성 유전자 ｑｎｒＳ를 갖는 신규한 다제내성 대장균 균주 및 이의 용도
CN116747227B (zh) * 2023-08-12 2025-07-25 杭州市第一人民医院 泊马度胺在制备抗细菌感染药物中的应用
WO2025093780A1 (en) * 2023-11-05 2025-05-08 Human Biome Institute S.A. The concept of drugs made with the gut microbiota and its components and the method of their administration to obtain effective therapeutic effects
WO2025093778A1 (en) 2023-11-05 2025-05-08 Human Biome Institute S.A. Functional compositions and methods of use thereof in eradication and/or decolonization of antibiotic-resistant bacteria and restoration of healthy microbiota

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CN103561752A (zh) * 2011-03-09 2014-02-05 明尼苏达大学评议会 用于移植结肠微生物群的组合物和方法
CN105473152A (zh) * 2013-06-05 2016-04-06 雷柏奥提斯有限公司 菌群恢复疗法（mrt）、组合物和制造方法
US20160143961A1 (en) * 2014-11-25 2016-05-26 Epiva Biosciences, Inc. Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease

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CN103561752A (zh) * 2011-03-09 2014-02-05 明尼苏达大学评议会 用于移植结肠微生物群的组合物和方法
CN105473152A (zh) * 2013-06-05 2016-04-06 雷柏奥提斯有限公司 菌群恢复疗法（mrt）、组合物和制造方法
US20160143961A1 (en) * 2014-11-25 2016-05-26 Epiva Biosciences, Inc. Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115812100A (zh) * 2020-09-01 2023-03-17 国立大学法人东北大学 乳汁中的IgA抗体含量的增加剂

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Publication number Publication date
CA3072029A1 (en) 2019-02-14
JP2020530493A (ja) 2020-10-22
KR20200037851A (ko) 2020-04-09
US20200093870A1 (en) 2020-03-26
WO2019032572A1 (en) 2019-02-14
AU2018313765A1 (en) 2020-02-27
US20240307460A1 (en) 2024-09-19
EP3665181A4 (en) 2021-06-09
EP3665181A1 (en) 2020-06-17

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