CA3072029A1 - Compositions and methods for decolonizing antibotic-resistant bacteria in the gut - Google Patents

Compositions and methods for decolonizing antibotic-resistant bacteria in the gut Download PDF

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Publication number
CA3072029A1
CA3072029A1 CA3072029A CA3072029A CA3072029A1 CA 3072029 A1 CA3072029 A1 CA 3072029A1 CA 3072029 A CA3072029 A CA 3072029A CA 3072029 A CA3072029 A CA 3072029A CA 3072029 A1 CA3072029 A1 CA 3072029A1
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CA
Canada
Prior art keywords
bacteria
firmicutes
clostridiales
clostridia
bacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3072029A
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English (en)
French (fr)
Inventor
Marina SANTIAGO
Kevin Roelofs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Finch Therapeutics Inc
Original Assignee
Finch Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Finch Therapeutics Inc filed Critical Finch Therapeutics Inc
Publication of CA3072029A1 publication Critical patent/CA3072029A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25Shigella (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3072029A 2017-08-07 2018-08-07 Compositions and methods for decolonizing antibotic-resistant bacteria in the gut Pending CA3072029A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762542033P 2017-08-07 2017-08-07
US62/542,033 2017-08-07
PCT/US2018/045592 WO2019032572A1 (en) 2017-08-07 2018-08-07 COMPOSITIONS AND METHODS FOR DECOLONIZING ANTIBIOTIC-RESISTANT BACTERIA IN INTESTINES

Publications (1)

Publication Number Publication Date
CA3072029A1 true CA3072029A1 (en) 2019-02-14

Family

ID=65272652

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3072029A Pending CA3072029A1 (en) 2017-08-07 2018-08-07 Compositions and methods for decolonizing antibotic-resistant bacteria in the gut

Country Status (8)

Country Link
US (2) US20200093870A1 (enExample)
EP (1) EP3665181A4 (enExample)
JP (1) JP2020530493A (enExample)
KR (1) KR20200037851A (enExample)
CN (1) CN111328331A (enExample)
AU (1) AU2018313765A1 (enExample)
CA (1) CA3072029A1 (enExample)
WO (1) WO2019032572A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011151941A1 (ja) 2010-06-04 2011-12-08 国立大学法人東京大学 制御性t細胞の増殖または集積を誘導する作用を有する組成物
CN104160014A (zh) 2011-12-01 2014-11-19 国立大学法人东京大学 诱导调节性t细胞的增殖或积累的人源细菌
CA3072032A1 (en) 2017-08-07 2019-02-14 Finch Therapeutics, Inc. Compositions and methods for maintaining and restoring a healthy gut barrier
WO2019079629A1 (en) * 2017-10-18 2019-04-25 Ascus Biosciences, Inc. IMPROVING POULTRY PRODUCTION BY ADMINISTERING A SYNTHETIC BIO-ASSEMBLY OF MICROBES OR PURIFIED STEM THEREFOR
EP3773645A4 (en) 2018-04-10 2021-11-24 Siolta Therapeutics, Inc. MICROBIAL CONSORTIA
WO2020132098A1 (en) * 2018-12-19 2020-06-25 Healthy Cow Corporation Ready-to-use probiotic compositions and uses thereof
PE20221399A1 (es) 2019-07-19 2022-09-15 Finch Therapeutics Holdings Llc Metodos y productos para el tratamiento de trastornos gastrointestinales
EP4021467A4 (en) * 2019-08-28 2023-09-13 Xbiome Inc. COMPOSITIONS CONTAINING BACTERIAL SPECIES AND ASSOCIATED METHODS
US12364721B2 (en) 2019-09-24 2025-07-22 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
WO2021071864A1 (en) 2019-10-07 2021-04-15 Siolta Therapeutics, Inc. Therapeutic pharmaceutical compositions
KR20220101637A (ko) * 2019-10-18 2022-07-19 핀치 테라퓨틱스 홀딩스 엘엘씨 박테리아 대사산물을 대상체에 전달하기 위한 조성물 및 방법
GB201915144D0 (en) * 2019-10-18 2019-12-04 Multigerm Uk Entpr Ltd Method of promoting SCFA production by gut microbiota
EP3838281A1 (en) * 2019-12-20 2021-06-23 4D Pharma Research Limited Compositions comprising bacterial strains
WO2021231804A2 (en) * 2020-05-13 2021-11-18 President And Fellows Of Harvard College Methods and compositions for suppressing inflammation induced by gut microbes
GB202007452D0 (en) * 2020-05-19 2020-07-01 Microbiotica Ltd Threrapeutic bacterial composition
WO2022036225A1 (en) 2020-08-14 2022-02-17 Prolacta Bioscience, Inc. Human milk oligosaccharide compositions for use with bacteriotherapies
WO2022050082A1 (ja) * 2020-09-01 2022-03-10 国立大学法人東北大学 乳汁中のIgA抗体含有量の増加剤
WO2022071423A1 (ja) * 2020-09-30 2022-04-07 国立研究開発法人国立がん研究センター ルミノコッカッセ腸内菌投与による免疫チェックポイント阻害薬の抗腫瘍効果の増強
JP2023550652A (ja) * 2020-11-25 2023-12-04 セレス セラピューティクス インコーポレイテッド 移植片対宿主病を処置するための設計された細菌組成物
US20230149483A1 (en) * 2021-11-12 2023-05-18 Iowa State University Research Foundation, Inc. Short-chain fatty acid use to mitigate antimicrobial resistance and virulence gene transfer in the gut
WO2023100989A1 (ja) * 2021-12-02 2023-06-08 国立大学法人東北大学 下痢治療剤および牛の下痢治療方法
KR102780901B1 (ko) * 2022-11-09 2025-03-17 주식회사 굿바이옴텍 베타-락탐계 항생제 내성 유전자 blaCTX-M-229 및 퀴놀론계 항생제 내성 유전자 qnrS를 갖는 신규한 다제내성 대장균 균주 및 이의 용도
CN116747227B (zh) * 2023-08-12 2025-07-25 杭州市第一人民医院 泊马度胺在制备抗细菌感染药物中的应用
WO2025093780A1 (en) * 2023-11-05 2025-05-08 Human Biome Institute S.A. The concept of drugs made with the gut microbiota and its components and the method of their administration to obtain effective therapeutic effects
WO2025093778A1 (en) 2023-11-05 2025-05-08 Human Biome Institute S.A. Functional compositions and methods of use thereof in eradication and/or decolonization of antibiotic-resistant bacteria and restoration of healthy microbiota

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US6727061B2 (en) * 1997-02-20 2004-04-27 Cabtec, Inc. Methods for identifying species or Shigella and E. coli using operon sequence analysis
ATE393221T1 (de) * 1999-11-29 2008-05-15 Avi Biopharma Inc Gegen bakterielle 16s und 23s rrnas gerichtete ungeladene antisense oligonukleotide und deren verwendungen
CN103561752B (zh) * 2011-03-09 2016-04-20 明尼苏达大学评议会 用于移植结肠微生物群的组合物和方法
CN104160014A (zh) * 2011-12-01 2014-11-19 国立大学法人东京大学 诱导调节性t细胞的增殖或积累的人源细菌
US8921335B2 (en) * 2012-01-31 2014-12-30 The Regents Of The University Of California Oral delivery of nucleic acid-based gene interfering agents by Salmonella
AU2014232370B2 (en) * 2013-03-15 2018-11-01 Société des Produits Nestlé S.A. Network-based microbial compositions and methods
AU2014275025B2 (en) * 2013-06-05 2016-12-01 Ferring Microbiome Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
MA41020A (fr) * 2014-11-25 2017-10-03 Evelo Biosciences Inc Compositions probiotiques et prébiotiques, et leurs procédés d'utilisation pour la modulation du microbiome
GB201519088D0 (en) * 2015-10-28 2015-12-09 Metabogen Ab The use of bacteria formulations
CA3072032A1 (en) * 2017-08-07 2019-02-14 Finch Therapeutics, Inc. Compositions and methods for maintaining and restoring a healthy gut barrier

Also Published As

Publication number Publication date
KR20200037851A (ko) 2020-04-09
EP3665181A1 (en) 2020-06-17
US20240307460A1 (en) 2024-09-19
JP2020530493A (ja) 2020-10-22
WO2019032572A1 (en) 2019-02-14
CN111328331A (zh) 2020-06-23
AU2018313765A1 (en) 2020-02-27
US20200093870A1 (en) 2020-03-26
EP3665181A4 (en) 2021-06-09

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