CN111295196A - 控制皮肤酶活性的分子细菌疗法 - Google Patents

控制皮肤酶活性的分子细菌疗法 Download PDF

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Publication number
CN111295196A
CN111295196A CN201880065645.XA CN201880065645A CN111295196A CN 111295196 A CN111295196 A CN 111295196A CN 201880065645 A CN201880065645 A CN 201880065645A CN 111295196 A CN111295196 A CN 111295196A
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staphylococcus
skin
aureus
activity
hominis
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R·L·伽罗
M·威廉姆斯
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C12R2001/25—Lactobacillus plantarum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/44—Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/44—Staphylococcus
    • C12R2001/45—Staphylococcus epidermidis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders
    • G01N2800/202—Dermatitis

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201880065645.XA 2017-08-31 2018-08-31 控制皮肤酶活性的分子细菌疗法 Pending CN111295196A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553025P 2017-08-31 2017-08-31
US62/553025 2017-08-31
PCT/US2018/049237 WO2019046801A1 (en) 2017-08-31 2018-08-31 MOLECULAR BACTERIOTHERAPY FOR CONTROLLING THE ENZYMATIC ACTIVITY OF THE SKIN

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CN111295196A true CN111295196A (zh) 2020-06-16

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US (2) US20210177917A1 (https=)
EP (1) EP3675884A4 (https=)
JP (2) JP7373176B2 (https=)
KR (1) KR20200083435A (https=)
CN (1) CN111295196A (https=)
AU (1) AU2018326791B2 (https=)
BR (1) BR112020003508A2 (https=)
CA (1) CA3072772A1 (https=)
MX (1) MX2020002013A (https=)
WO (1) WO2019046801A1 (https=)

Cited By (6)

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CN111870225A (zh) * 2020-08-04 2020-11-03 中国科学技术大学 一种用于荧光标定的标准模板制作方法
CN112778399A (zh) * 2021-01-21 2021-05-11 南开大学 一类源自毒性淀粉样纤维纳米抗菌肽的制备及性质表征方法
CN113234125A (zh) * 2021-05-10 2021-08-10 华东理工大学 自组装多肽、多肽水凝胶及其制备方法和用途
CN116515662A (zh) * 2022-08-05 2023-08-01 山东福瑞达生物股份有限公司 一株抗炎阿尔莱特葡萄球菌及其应用
CN116694535A (zh) * 2023-07-20 2023-09-05 四川大学 一种戊糖乳杆菌w19及其应用
CN119326709A (zh) * 2024-11-07 2025-01-21 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) 一种表皮葡萄球菌h62-3代谢产物凝胶制剂及其制备方法与应用

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EP3072899B1 (en) * 2015-03-23 2018-05-02 Eberhard Karls Universität Tübingen Novel anti-infective compound
JP7678518B2 (ja) * 2019-06-21 2025-05-16 ポーラ化成工業株式会社 スタフィロコッカス・ホミニス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ｈｏｍｉｎｉｓ）を有効成分とする肌状態改善剤
KR102286076B1 (ko) * 2019-09-27 2021-08-05 코스맥스 주식회사 스타필로코커스 갈리나룸 st-4 균주 및 그의 피부 상태 개선 용도
KR102199065B1 (ko) * 2019-09-27 2021-01-06 코스맥스 주식회사 스타필로코커스 코니이 st-3 균주 및 그의 피부 상태 개선 용도
KR102195998B1 (ko) * 2019-09-27 2020-12-29 코스맥스 주식회사 스타필로코커스 시뮬란스 st-9 균주 및 그의 피부 상태 개선 용도
KR102195995B1 (ko) * 2019-09-27 2020-12-29 코스맥스 주식회사 스타필로코커스 슐레이페리 st-13 균주 및 그의 피부 상태 개선 용도
KR102199062B1 (ko) * 2019-09-27 2021-01-06 코스맥스 주식회사 스타필로코커스 자일로서스 st-10 균주 및 그의 피부 상태 개선 용도
KR102195996B1 (ko) * 2019-09-27 2020-12-29 코스맥스 주식회사 스타필로코커스 와르네리 st-12 균주 및 그의 피부 상태 개선 용도
KR102286075B1 (ko) * 2019-09-27 2021-08-05 코스맥스 주식회사 스타필로코커스 렌투스 st-2 균주 및 그의 피부 상태 개선 용도
KR102286077B1 (ko) * 2019-09-27 2021-08-05 코스맥스 주식회사 스타필로코커스 에피더미디스 st-6 균주 및 그의 피부 상태 개선 용도
KR102233385B1 (ko) * 2019-09-27 2021-03-29 코스맥스 주식회사 스타필로코커스 캐피티스 st-1 균주 및 그의 피부 상태 개선 용도
JP2023512215A (ja) * 2020-01-29 2023-03-24 ザ ジャクソン ラボラトリー 細菌混和物
WO2022087065A1 (en) * 2020-10-21 2022-04-28 The Jackson Laboratory Antimicrobial biosensors
JP2024508541A (ja) * 2021-03-05 2024-02-27 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 皮膚プロバイオティクス
CN113730648B (zh) * 2021-09-06 2022-11-01 温州瑞司特生物科技有限公司 结合表皮葡萄球菌的水凝胶及其在治疗创面中的应用
KR102609655B1 (ko) * 2022-07-27 2023-12-06 코스맥스 주식회사 스트렙토코커스 소브리너스 균주 및 그의 피부 상태 개선 용도
KR102855516B1 (ko) * 2022-06-03 2025-09-08 코스맥스 주식회사 스타필로코커스 아우리큘라리스 균주 및 그의 피부 상태 개선 용도
KR102855517B1 (ko) * 2022-06-03 2025-09-05 코스맥스 주식회사 스타필로코커스 코흐니 균주 및 그의 피부 상태 개선 용도
KR102609656B1 (ko) * 2022-06-03 2023-12-06 코스맥스 주식회사 스타필로코커스 호미니스 균주 및 그의 피부 상태 개선 용도
WO2024158103A1 (ko) * 2023-01-25 2024-08-02 코스맥스 주식회사 스트렙토코커스 속 균주를 포함하는 피부 질환의 예방, 개선 또는 치료용 조성물
WO2025240841A1 (en) * 2024-05-16 2025-11-20 The Regents Of The University Of California Antimicrobial therapy

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111870225A (zh) * 2020-08-04 2020-11-03 中国科学技术大学 一种用于荧光标定的标准模板制作方法
CN112778399A (zh) * 2021-01-21 2021-05-11 南开大学 一类源自毒性淀粉样纤维纳米抗菌肽的制备及性质表征方法
CN113234125A (zh) * 2021-05-10 2021-08-10 华东理工大学 自组装多肽、多肽水凝胶及其制备方法和用途
CN113234125B (zh) * 2021-05-10 2022-12-06 华东理工大学 自组装多肽、多肽水凝胶及其制备方法和用途
CN116515662A (zh) * 2022-08-05 2023-08-01 山东福瑞达生物股份有限公司 一株抗炎阿尔莱特葡萄球菌及其应用
CN116694535A (zh) * 2023-07-20 2023-09-05 四川大学 一种戊糖乳杆菌w19及其应用
CN119326709A (zh) * 2024-11-07 2025-01-21 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) 一种表皮葡萄球菌h62-3代谢产物凝胶制剂及其制备方法与应用

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WO2019046801A1 (en) 2019-03-07
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