CN111265600A - Application of jackfruit extract in preparing weight-reducing preparation - Google Patents
Application of jackfruit extract in preparing weight-reducing preparation Download PDFInfo
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- CN111265600A CN111265600A CN202010192998.5A CN202010192998A CN111265600A CN 111265600 A CN111265600 A CN 111265600A CN 202010192998 A CN202010192998 A CN 202010192998A CN 111265600 A CN111265600 A CN 111265600A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 244000025352 Artocarpus heterophyllus Species 0.000 title claims description 11
- 235000008725 Artocarpus heterophyllus Nutrition 0.000 title claims description 11
- 235000016089 Ananas bracteatus Nutrition 0.000 claims abstract description 33
- 229940013712 pineapple extract Drugs 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
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- 239000000243 solution Substances 0.000 claims description 9
- 230000037396 body weight Effects 0.000 claims description 6
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- 238000001914 filtration Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 241001633663 Iris pseudacorus Species 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 abstract description 22
- 238000013116 obese mouse model Methods 0.000 abstract description 3
- 241001189227 Ananas comosus var. bracteatus Species 0.000 abstract 3
- 230000000694 effects Effects 0.000 description 12
- 238000010172 mouse model Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
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- 235000012631 food intake Nutrition 0.000 description 2
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- 244000099147 Ananas comosus Species 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
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Abstract
The invention relates to an application of a wild pineapple extract in preparing a weight-reducing preparation, wherein the wild pineapple extract is a hot water extract. The wild pineapple extract can effectively control the weight increasing trend of obese mice, reduce the fat proportion in the mice, relieve the fatty lesion of the livers of the mice and have the prospect of preparing weight-reducing preparations.
Description
Technical Field
The invention relates to an application of a wild pineapple extract in preparing a weight-reducing preparation, belonging to the field of medicine and health.
Academic background
The World Health Organization (WHO) reported that over 19 billion of adults aged 18 and older worldwide were overweight in 2016, with over 6.5 billion people obese, over 3.4 billion children aged 5-19 and adolescents being overweight or obese. Compared with normal people, obese people are more likely to suffer from diseases such as hyperlipidemia, hyperglycemia, hypertension and the like.
Wild pineapple is the fruit of Acanthopanax trifoliatus (Pandanus tectorius (L). Because of its shape similar to pineapple, Lingnan is commonly called wild pineapple. The wild pineapple is widely distributed in Hainan, has rich resources, can be eaten as wild fruits in folk, has sweet pulp, but is rich in vascular tissues and poor in taste, so that the wild pineapple is not popular, and is used for treating dysentery and cough in the Hainan folk. The root, leaf, etc. of Acanthopanax trifoliatus can be used as medicine, and has effects of clearing heat and eliminating dampness, promoting diuresis and relieving exterior syndrome, activating qi-flowing and calming liver. Modern pharmacological studies show that the effective components of the jackfruit can regulate the lipid metabolism of diabetic mice, reduce fat accumulation in vivo and improve insulin resistance. The wild pineapples have a history of being eaten as wild fruits for a long time, and no report of toxic or side effect is generated after eating at present, so that the safety is high, and the development of weight-losing health-care food is facilitated.
Disclosure of Invention
The invention obtains the wild pineapple extract by a hot water extraction method, and animal experiments prove that the wild pineapple extract has obvious weight-losing effect.
The technical scheme of the invention is realized as follows:
the application of the wild pineapple extract in preparing the weight-reducing preparation is that the wild pineapple extract is a hot water extract.
Further, the application of the jackfruit extract in preparing a preparation for reducing the weight of an obesity model mouse.
Further, the application of the jackfruit extract in preparing a preparation for reducing the fat/body weight ratio of an obesity model mouse.
Furthermore, the application of the jackfruit extract in preparing a preparation for reducing fatty lesions of mouse liver is provided.
Further, the preparation method of the wild pineapple extract comprises the following steps: cleaning wild pineapple with water, drying, adding water, heating to boil, extracting for 1.5 hr, filtering, collecting extractive solution, extracting with water once, mixing the extractive solutions, heating, and concentrating to obtain wild pineapple extract (YBL).
Further, the wild pineapple is dried, added with water and soaked overnight, and then extracted.
Furthermore, in the extraction process of the wild pineapple, 3 liters of water is added into each kilogram of the wild pineapple.
Further, in the application, the wild pineapple extract is prepared into an aqueous solution for use.
Furthermore, in the application, the concentration of the wild pineapple extract is 0.6-2.4 mg/mL.
Has the advantages that:
the wild pineapple extract can effectively control the weight increasing trend of obese mice, reduce the fat proportion in the mice, relieve the fatty lesion of the livers of the mice and have the prospect of preparing weight-reducing preparations.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a graph of the effect of YBL on body weight in obese model mice;
FIG. 2 is a graph of the effect of YBL on appetite in obese model mice;
FIG. 3 is a graph of the effect of YBL on fat/body weight ratio in obese model mice;
FIG. 4 is a graph of the effect of YBL on weight gain in obese model mice;
p <0.05, p <0.01 in figures 1-4 compared to the model group; compared to the normal group, # p <0.05, # p < 0.01;
FIG. 5 shows the effect of YBL on the pathological morphology of liver tissue in obese model mice.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
1. Preparation method of extract of Ananas comosus
Cleaning wild pineapple with water, drying, adding 3L of water per kg, and soaking overnight. Heating to boil, extracting for 1.5 hr, filtering, collecting extractive solution, extracting with water once, mixing extractive solutions, heating, and concentrating to obtain extract (YBL). The yield of the extract was 3.24%.
2. Experimental study on weight-reducing effect of jackfruit extract
An animal experiment research scheme for the weight-reducing effect of the wild pineapple extract is designed by referring to an evaluation method of the weight-reducing efficacy of the health food established by the weight-reducing function evaluation method of food and drug administration [2012] 107.
70 male mice of SPF grade 16-20g aged 7 weeks C57BL/6 were selected. After 5 days of adaptive feeding, 60 mice were fed with TP23300 type high-fat high-sugar obesity model feed to induce obesity model, and another 10 mice were fed with TP23302 type control feed as blank control group, which were all provided by Nantong Telofia feed science and technology Co.
The obesity model was fed on week 4 (day 24) with 60 mice ranked by weight gain, and 1/3 obesity resistant mice with lower weight gain were eliminated. The 40 screened obesity sensitive mice were randomly divided into 4 groups: the model group, the YBL high dose group, the YBL medium dose group and the YBL low dose group are continuously fed with the obesity model feed, and the blank control group is continuously fed with the low-fat low-sugar control feed. All mice were housed in a single cage. The obesity model was fed to animals at 5 weeks (day 30) with YBL dissolved in drinking water to a concentration of 2.4mg/mL,1.2mg/mL, 0.6mg/mL, and administered to the YBL high, medium, and low dose groups for drinking. The food intake, food consumption, food remaining, water intake, and weight change were recorded for each group of animals every week.
After feeding the obesity model with the feed for 13 weeks (day 54 of YBL intervention), all mice were fasted for 12h, then the mice were sacrificed by removing cervical vertebrae, the abdomen was opened, the abdominal fat accumulation was recorded by photographing, the perirenal fat and the peritesticular fat were taken and weighed, and the fat/body ratio was calculated. Taking a part of liver tissue, storing in 4% paraformaldehyde, preparing pathological sections, and observing pathological changes after HE staining; the other part was stored at-80 ℃ for testing.
3 results of the experiment
3.1 Effect of Jacob's apple extract on weight, feed, fat/body ratio, and weight gain in obese model mice
Mice fed the high-fat high-sugar obesity model diet for 4 weeks had a significant weight gain (p <0.05) compared to normal mice fed the control diet, after which the difference in body weight became greater and the fat/body weight ratio increased significantly. At the end of the experiment at week 13, the intervention group mice, which had daily drinking a solution of wild pineapple extract (YBL) (concentration 2.4mg/mL,1.2mg/mL), weighed less and gained weight (p < 0.05-0.01) and had a lower fat/body ratio (p <0.05) than the obesity model group mice. The amount of feed consumed daily by each group of mice during the experiment did not differ significantly. The results are shown in detail in FIGS. 1-4.
The results show that the dry prognosis of the jackfruit extract can effectively control the weight increasing trend of the obese mice and reduce the fat proportion in the body.
3.2 Effect of wild pineapple extract on the pathological morphology of the liver tissue of the obese model mouse
When the liver tissue slices of the mice in each group were observed under an HE staining microscope, as shown in FIG. 5, it was found that the fat accumulation in the liver tissue of the mice in the obesity model was significant, the cell morphology was large, and the peripheral steatosis was observed. The YBL administration group mice reduce fatty lesion of liver to different degrees.
The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.
Claims (9)
1. The application of the wild pineapple extract in preparing the weight-reducing preparation is characterized in that: the wild pineapple extract is a hot water extract.
2. The use of claim 1, wherein: the application of the jackfruit extract in preparing a preparation for reducing the weight of an obesity model mouse is provided.
3. The use of claim 1, wherein: the application of the jackfruit extract in preparing a preparation for reducing the fat/body weight ratio of an obesity model mouse is provided.
4. The use of claim 1, wherein: the application of the jackfruit extract in preparing a preparation for reducing fatty lesions of mouse liver.
5. The use according to any one of claims 1 to 4, wherein the extract of Jacob's wort is prepared by: cleaning herba Ananadis Comosi with water, drying, adding water, heating to boil, extracting for 1.5 hr, filtering, collecting extractive solution, extracting with water once, mixing the extractive solutions, heating, and concentrating to obtain herba Ananadis Comosi extract.
6. The use of claim 5, wherein: the wild pineapple is dried, soaked in water overnight, and then extracted.
7. The use of claim 5, wherein: in the extraction process of the wild pineapple, 3 liters of water is added into each kilogram of the wild pineapple.
8. The use according to any one of claims 1 to 4, wherein: in the application, the wild pineapple extract is prepared into an aqueous solution for use.
9. The use according to any one of claims 1 to 4, wherein: in the application, the concentration of the wild pineapple extract is 0.6-2.4 mg/mL.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010192998.5A CN111265600A (en) | 2020-03-18 | 2020-03-18 | Application of jackfruit extract in preparing weight-reducing preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010192998.5A CN111265600A (en) | 2020-03-18 | 2020-03-18 | Application of jackfruit extract in preparing weight-reducing preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113072650A (en) * | 2021-03-30 | 2021-07-06 | 海南云皓生物科技有限公司 | Preparation method of jackfruit polysaccharide |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301256A (en) * | 2012-03-08 | 2013-09-18 | 中国医学科学院药用植物研究所 | Preparation method of medicinal plant extract being capable of reducing blood fat and application thereof in pharmacy and health food |
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2020
- 2020-03-18 CN CN202010192998.5A patent/CN111265600A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301256A (en) * | 2012-03-08 | 2013-09-18 | 中国医学科学院药用植物研究所 | Preparation method of medicinal plant extract being capable of reducing blood fat and application thereof in pharmacy and health food |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113072650A (en) * | 2021-03-30 | 2021-07-06 | 海南云皓生物科技有限公司 | Preparation method of jackfruit polysaccharide |
| CN113072650B (en) * | 2021-03-30 | 2022-01-21 | 海南云皓生物科技有限公司 | Preparation method of jackfruit polysaccharide |
| WO2022205518A1 (en) * | 2021-03-30 | 2022-10-06 | 海南云皓生物科技有限公司 | Method for preparing pandanus tectorius polysaccharide |
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Application publication date: 20200612 |