CN111265420A - Efficient moisturizing and allergy-relieving repairing composition and application thereof - Google Patents
Efficient moisturizing and allergy-relieving repairing composition and application thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/522—Antioxidants; Radical scavengers
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Abstract
The invention relates to the field of protection of damage from environmental stress factors, in particular to a high-efficiency moisturizing and allergy-relieving repairing composition and application thereof. The high-efficiency moisturizing and allergy-relieving repairing composition comprises a) ectoin in percentage by mass; b) ergothioneine or a pharmaceutically acceptable salt or ester thereof; c) cannabinoid is used as effective component, and the content of the effective component in the composition is 0.5-5%. The composition has effects in relieving sensitivity, repairing skin micro-injury, repairing after sunburn, and repairing skin barrier after domestic acid brushing; the 4D hyaluronic acid can be matched to moisten the skin instantly, establish an invisible protective film, resist external stimulation, build a skin protective layer and lock effective components, so that the aims of high-efficiency moisturizing and allergy-relieving repair are fulfilled.
Description
Technical Field
The invention relates to the field of protection of damage from environmental stress factors, in particular to a high-efficiency moisturizing and allergy-relieving repairing composition and application thereof.
Background
Statistics have stated that about 65% of the world population is suffering or has suffered from skin sensitivity problems. The skin allergy is caused by factors inherent in the human body and external factors such as the environment. With age, the skin is often attacked by a variety of environmental stressors, such as Ultraviolet (UV) radiation from the sun, smoke, dust, and infrared, which produce free ions. These stressors can cause damage to the skin, which accumulates with age and can lead to chronic inflammation, DNA damage and oxidative stress (ROS), thereby weakening the natural resistance of the skin and leading to a decrease in the self-healing function of the skin.
In addition, various additives in cosmetics have a more or less irritating effect on the skin. When the skin is subjected to such damage or irritation, and the skin protective function is reduced, allergic phenomena such as redness, swelling, pain, itching or papular desquamation can occur.
In order to protect against environmental stressors and to repair the damage caused by these stressors, researchers have developed topical cosmetic and dermatological formulations containing certain active ingredients. For example, researchers have found ergothioneine to be a powerful antioxidant, capable of combating skin aging. Because of the benefits of this compound, it is included in a wide variety of products available on the market.
Despite the recognition of the benefits of use by many consumers, researchers are still looking for ways to provide new and improved products that can prevent or repair damage caused by environmental stressors.
Disclosure of Invention
In order to solve the above technical problems, the first aspect of the present invention provides a highly effective moisturizing and soothing repairing composition comprising, in mass percent, a) ectoin; b) ergothioneine or a pharmaceutically acceptable salt or ester thereof; c) cannabinoid is used as effective component, and the content of the effective component in the composition is 0.5-5%.
As a preferable technical scheme, the mass ratio of the ectoine, the ergothioneine and the cannabinoid is (2-5): (2-5): (0.5-1).
As a preferable technical scheme, the effective component also comprises d) ceramide, and the content of the ceramide in the composition is 0.1-1 wt%.
As a preferred embodiment, the ceramide is selected from the group consisting of compounds of the following formula (1):
wherein: (1)
-R1represents a linear or branched, saturated or unsaturated C9-C30 hydrocarbon radical, wherein the radical may be substituted by one or more hydroxyl groups, wherein these hydroxyl groups are optionally esterified with saturated or unsaturated C16-C30 fatty acids; or a radical R "- (NR-CO) -R ', in which R represents a hydrogen atom or a mono-or polyhydroxylated, preferably monohydroxylated, C1-C10 hydrocarbon radical and R ' and R" are hydrocarbon radicals whose sum of the numbers of carbon atoms is from 9 to 30 and R ' is a divalent radical;
-R2represents a hydrogen atom, or a (glycosyl) n, (galactosyl) m or sulfogalactosyl group, wherein n is an integer from 1 to 4 and m is an integer from 1 to 8;
-R3represents a hydrogen atom, or a saturated or unsaturated C16-C27 hydrocarbon group, wherein said group may be substituted by one or more C1-C14 alkyl groups; r3And may also represent C15-C26 α -hydroxyalkyl, the hydroxy group of which may optionally be esterified with a C16-C30 α -hydroxy acid;
-R4represents a hydrogen atom, a saturated or unsaturated C16-C27 hydrocarbon group or a-CH 2-CHOH-CH2-O-R6 group, wherein R6 represents a C10-C26 hydrocarbon group;
-R5represents a hydrogen atom, or a mono-or polyhydroxylated C1-C4 hydrocarbon group.
As a preferable technical scheme, the ceramide is natural ceramide, and is selected from one or more of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6ll, ceramide 7, ceramide 8 and ceramide 9.
As a preferable technical scheme, the mass ratio of the ceramide 1 to the ceramide 3 to the ceramide 6ll (3-6): (1-3): 1.
as a preferable technical scheme, the composition also comprises 0.5 to 5 percent of acetylcysteine, 5 to 20 percent of alcohol and the balance of water by mass percent.
As a preferable technical scheme, the hyaluronic acid also comprises 1-5% of 4D hyaluronic acid by mass percent.
As a preferred technical solution, the 4D hyaluronic acid comprises hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, and sodium hyaluronate cross-linked polymer.
In a second aspect, the present invention provides the use of a high performance moisturizing and soothing skin care composition comprising 0.5-5% of the above active ingredient, 0.5-5% of chitosamine, 5-20% of alcohols, 1-5% of 4D hyaluronic acid, and the balance water in a cosmetic, preferably in the form of a solution, emulsion, viscous mixture.
In a third aspect, the present invention provides the use of a highly effective moisturizing and soothing composition comprising 0.5-5% of the above active ingredient, 0.5-5% of acetylcysteine, 5-20% of an alcohol, and the balance water in a pharmaceutical product, preferably, a skin external preparation.
Has the advantages that: the invention provides a high-efficiency moisturizing and allergy-relieving repairing composition, which comprises a) ectoin; b) ergothioneine or a pharmaceutically acceptable salt or ester thereof; c) cannabinoids; d) ceramide as effective component has effects of relieving sensitivity, repairing skin micro-injury, repairing after sunburn, and repairing skin barrier after domestic acid brushing; the 4D hyaluronic acid can be matched to moisten the skin instantly, establish an invisible protective film, resist external stimulation, build a skin protective layer and lock effective components, so that the aims of high-efficiency moisturizing and allergy-relieving repair are fulfilled.
Drawings
FIG. 1: face image before using the product of example 3;
FIG. 2: facial images after 14 days of continuous use of the product of example 3.
Detailed Description
Unless otherwise indicated, implied from the context, or customary in the art, all parts and percentages herein are by weight and the testing and characterization methods used are synchronized with the filing date of the present application. To the extent that a definition of a particular term disclosed in the prior art is inconsistent with any definitions provided herein, the definition of the term provided herein controls.
The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.
The words "preferred", "preferably", "more preferred", and the like, in the present invention, refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention. The sources of components not mentioned in the present invention are all commercially available.
In order to solve the above technical problems, the first aspect of the present invention provides a highly effective moisturizing and soothing repairing composition comprising, in mass percent, a) ectoin; b) ergothioneine or a pharmaceutically acceptable salt or ester thereof; c) cannabinoid is used as effective component, and the content of the effective component in the composition is 0.5-5%.
a) Ectoin
The term Ectoin (Ectoin) refers to a substance derived from highly halophilic bacteria (Halomonas Elongata), and is also referred to as "halotolerant bacteria extract". Chemical name: 2-methyl-1, 4,5,6, -tetrahydropyrimidine-4-carboxylic acid. Under the extreme conditions of high salt, high temperature and high ultraviolet radiation, the ectoin can prevent halophilic bacteria from being damaged. Research shows that ectoin can effectively improve the immune protection capability of skin cells, increase the cell repair capability and enable the skin to effectively resist the invasion of microorganisms and allergens.
The ectoin is used in cosmetics, and can reduce the water loss rate of epidermis and increase skin moisture by stabilizing skin barrier and repairing and regulating skin humidity; in addition, more "acids" or "antioxidants" are commonly used in certain cosmetics, and "ectoin" is added to help reduce skin sensitivity and irritation in order to increase skin "tolerance".
The 4D hyaluronic acid has four structures with different molecular weights, namely small, medium, high and low, and can play a role in replenishing water and locking water in different cell layers of the skin, the moisture retention is remarkably improved and the stability is slightly improved with the addition of ectoin and ergothioneine, probably because the ergothioneine can combine 4 water molecules due to the unique structure, the existence of the ectoin promotes a water-electricity complex formed by the ergothioneine and surrounding water molecules, and the complex of the ectoin, the ectoin and the ergothioneine can form a protective, nourishing and stable hydration shell around the cells.
b) Ergothioneine or a pharmaceutically acceptable salt or ester thereof
It will be appreciated by those of ordinary skill in the art that when referring to a molecule or a pharmaceutically acceptable salt or ester thereof, the molecule may be present predominantly or exclusively in neutral pH form, predominantly or exclusively in acidic form (e.g., having a carboxylic acid group), predominantly or exclusively in basic form, predominantly or exclusively in salt form or a combination of different forms. The number of different forms may be determined by standard equilibrium equations, environmental conditions of the formulation, and other components of the formulation.
The ergot sulfur has unique oxidation resistance and sun-screening function, and can remarkably slow down the skin aging phenomena such as fine lines, wrinkles, sagging and the like when being added into a skin care product; when used together with certain antioxidants, the whitening and anti-aging agent has good synergistic whitening and anti-aging strengthening effects.
In a preferred embodiment, the ergothioneine or a pharmaceutically acceptable salt or ester thereof is specifically ergothioneine.
The term ergothioneine refers to 3- (2-sulfonylidene-1, 3-dihydroimidazol-4-yl) -2- (trimethylammonium) propionate. Ergothioneine has free radical scavenging ability. It can therefore be advantageously used to repair damage caused by environmental stressors such as UV radiation and other carcinogens.
The ergothioneine is purchased from Kenuojii Biotech, Inc. in Tianjin.
c) Cannabinoid
The term cannabinoid (English: Cannabinoids), which is found in Indian hemp (Cannabis sativa), is naturally present in the nervous and immune systems of animals. Tetrahydrocannabinol (THC), Cannabidiol (CBD) are the major chemical components in cannabis.
In a preferred embodiment, the cannabinoid is cannabidiol.
The term cannabidiol, CBD, english: cannabidial (Chinese translated as cannabidiol or cannabidiol, or Cannabis sincere feeling) is a pure natural ingredient extracted from the cannabis plant. It provides the most effective anti-aging, anti-oxidation and autoimmune effects, and in combination with other organic pure compounds, it provides the most natural care for skin.
Cannabidiol as described in the present invention was purchased from Yunnan Hansu Biotechnology Ltd.
The cannabidiol of the invention is generally insoluble in water and is poorly compatible in the system. However, in the composition of the present invention, cannabidiol with a purity of more than 99%, although actually very poor in solubility, can be maintained stably in the system by controlling its own weight ratio, may be hydroxyl hydrogen-bonded cannabidiol of chitosan, and is present in a layered structure formed by 4D hyaluronic acid and ergothioneine cations, improving its solubility and stability.
In a preferred embodiment, the mass ratio of the ectoine, ergothioneine and cannabinoid is (2-5): (2-5): (0.5-1); more preferably 4: 3: 0.8.
in a preferred embodiment, the active ingredient further comprises d) ceramide, and the ceramide is contained in the composition in an amount of 0.1 to 1%.
d) Ceramide
The term Ceramide (Ceramide) is a class of phospholipids with Ceramide as the backbone, mainly Ceramide phosphorylcholine and Ceramide phosphorylethanolamine, phospholipids are the major components of cell membranes, 40% to 50% of the sebum in the stratum corneum is composed of Ceramide, Ceramide is a major part of the intercellular matrix, and plays an important role in maintaining the moisture balance of the stratum corneum.
In a preferred embodiment, the ceramide is selected from the group consisting of compounds of the following formula (1):
wherein: (1)
-R1represents a linear or branched, saturated or unsaturated C9-C30 hydrocarbon radical, wherein the radical may be substituted by one or more hydroxyl groups, wherein these hydroxyl groups are optionally esterified with saturated or unsaturated C16-C30 fatty acids; or a radical R "- (NR-CO) -R ', in which R represents a hydrogen atom or a mono-or polyhydroxylated, preferably monohydroxylated, C1-C10 hydrocarbon radical and R ' and R" are hydrocarbon radicals whose sum of the numbers of carbon atoms is from 9 to 30 and R ' is a divalent radical;
-R2represents a hydrogen atom, or a (glycosyl) n, (galactosyl) m or sulfogalactosyl group, wherein n is an integer from 1 to 4 and m is an integer from 1 to 8;
-R3represents a hydrogen atom, or a saturated or unsaturated C16-C27 hydrocarbon group, wherein said group may be substituted by one or more C1-C14 alkyl groups; r3And may also represent C15-C26 α -hydroxyalkyl, the hydroxy group of which may optionally be esterified with a C16-C30 α -hydroxy acid;
-R4represents a hydrogen atom, a saturated or unsaturated C16-C27 hydrocarbon group or a-CH 2-CHOH-CH2-O-R6 group, wherein R6 represents a C10-C26 hydrocarbon group;
-R5represents a hydrogen atom, or a mono-or polyhydroxylated C1-C4 hydrocarbon group.
In a preferred embodiment, the ceramide is a natural ceramide selected from one or more of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6ll, ceramide 7, ceramide 8, ceramide 9.
In a preferred embodiment, the mass ratio of ceramide 1, ceramide 3 and ceramide 6ll (3-6): (1-3): 1; more preferably 5: 2: 1.
the combination of ceramide 1, ceramide 3, ceramide 6ll, which may be referred to as a triple ceramide, may enhance skin oxidative stability, prevent allergy, and re-construct the skin barrier.
In a preferred embodiment, the composition further comprises 0.5-5% of the acetylcysteine, 5-20% of the alcohol and the balance of water in percentage by mass.
The term acetoacetsamine, chemical name: N-acetyl-D-glucosamine, which is the basic unit of many important polysaccharides in biological cells, has many important physiological functions in organisms. The micro-molecular amino monosaccharide obtained through biological fermentation has excellent transdermal absorbability, can improve the hydration of skin, is a high-quality multifunctional humectant, and is widely applied to various cosmetic formula systems.
In a preferred embodiment, the alcohol is a small molecule polyol.
In a preferred embodiment, the mass ratio of ergothioneine to alcohol is 1: (15-20).
The mass ratio of the ergothioneine to the alcohol in the invention is 1: (15-20), the system is best in low-temperature stability and high-temperature stability, presumably because the ion-hydrophilic action of ergothioneine and low-molecular alcohols containing the cation amino acid inner salt reaches equilibrium, and when the content of ergothioneine is high, the equilibrium with small molecules of alcohols is broken, so that water-insoluble cannabidiol is easily dissociated from the system, and the stability is reduced.
Examples of small molecule polyols include, but are not limited to, hexylene glycol, ethylene glycol, propylene glycol, glycerin, butylene glycol.
In a preferred embodiment, the alcohols include 1, 3-butanediol, 1, 2-pentanediol.
In a more preferred embodiment, the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of 1, 3-butanediol to 1, 2-pentanediol is (5-15): (1-3); most preferably 9: 2.
in a preferred embodiment, the hyaluronic acid also comprises 1-5% of 4D hyaluronic acid by mass percent.
In a preferred embodiment, the 4D hyaluronic acid comprises hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, a sodium hyaluronate crosspolymer.
The term 4D hyaluronic acid is 4-fold water-activating technology, which is beneficial to building a three-dimensional water storage sponge layer by using hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, sodium hyaluronate and sodium hyaluronate cross-linked polymer with the molecular weights from small to large, accurately positioning different layers of skin, moisturizing the outer layer, locking water in the inner layer, moisturizing the skin layer by layer, and moisturizing and brightening the skin from inside to outside.
The 4D hyaluronic acid of the invention was purchased from Huaxi organism, Hymagic-4D.
Composition/formulation
The highly effective moisturizing and soothing repairing composition of the present invention may be referred to as ECTOINCARETMThe composition is applied to affected areas of the skin and is maintained on the affected areas in an amount effective to provide significant improvement in skin condition and aesthetics, for example, when applied to the face, 14 days later it is found to provide significant reduction in redness, significant increase in skin moisture, enhancement of the stratum corneum, and a clear and ruddy appearance of the skin, and after one week of its inactivity, the skin condition is maintained. It can thus be seen that the present invention is very effective in the repair of skin.
The composition of the present invention can be used in various applications to form various formulations without particular limitation. For example, the composition may be formulated for external skin application, particularly as a cosmetic or pharmaceutical composition.
When it is used as a cosmetic, the cosmetic is preferably in the form of a solution, emulsion, viscous mixture, or the like.
As the ingredient contained in the cosmetic composition of the present invention, an ingredient generally used in cosmetic compositions, for example, a usual auxiliary agent and carrier such as a stabilizer, a dissolving agent, a vitamin, a pigment and a perfume may be further contained.
The cosmetic composition of the present invention may be in any form conventionally prepared in the art, and examples thereof include lotions, creams, lotions, masks, foundations, lotions, beauty solutions, hair cosmetics, and the like.
Specifically, the cosmetic composition of the present invention includes dosage forms of skin cream, skin softening lotion, skin toning lotion, skin firming lotion, skin lotion, moisturizing lotion, nourishing lotion, massaging cream, nourishing cream, moisturizing cream, hand cream, foundation, essence, nourishing essence, mask, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion, and body bath.
When the formulation of the present invention is an ointment, cream or gel, animal fibers, plant fibers, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicon, bentonite, silica, talc or zinc oxide and the like can be used as a carrier component.
In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and particularly in the case of a spray, a propellant such as chlorofluorocarbon, propane/butane or dimethylether may be further contained.
When the formulation of the present invention is a solution or emulsion, a solvent, a solvating agent or an emulsifying agent, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3-butylene glycol oil, aliphatic glyceride, polyethylene glycol or sorbitan fatty acid ester, is used as a carrier component.
In the case where the dosage form of the present invention is a suspension, as a carrier ingredient, a liquid diluent such as water, ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyethylene oxide sorbitol ester and polyethylene oxide sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth, or the like can be used.
When the formulation of the present invention is a surfactant-containing detergent, fatty alcohol sulfate, fatty alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linoleotide derivative, ethoxylated glycerol fatty acid ester, or the like can be used as the carrier component.
When it is used as a pharmaceutical product, the preferred pharmaceutical product is a skin external preparation, and the preparation may further comprise an analgesic or an anti-inflammatory compound, such as ibuprofen, diclofenac, capsaicin, salicylate, tyroprofen, felbinac, piroxicam, corticosteroids and NSAIDs (non-steroidal anti-inflammatory drugs); or may further comprise an antifungal agent, such as including, but not limited to, amphotericin B, candida, dermatan, filipin, nystatin, archamycin, hamycin, mithramycin, mepartricin, natamycin, nystatin, cinacalnine; or may further include antiviral agents such as, but not limited to, acyclovir, cidofovir, cytarabine, dideoxyadenosine, didanosine zidovudine (AZT), and danazolic acid; anesthetic agents may also be included.
The present invention is described in detail below with reference to examples, which are provided for the purpose of further illustration only and are not to be construed as limiting the scope of the present invention, and the insubstantial modifications and adaptations thereof by those skilled in the art based on the teachings of the present invention will still fall within the scope of the present invention.
Example 1
Example 1 provides a high-efficacy moisturizing and soothing repairing composition, which comprises 1% of active ingredients, 1.5% of chitosamine, 1% of 4D hyaluronic acid, 8% of alcohols and the balance of water in percentage by mass.
The effective components comprise: a) ectoin; b) ergothioneine; c) the cannabinoid is used as an effective component, and the mass ratio of the ectoine, the ergothioneine and the cannabinoid is 5: 2: 0.5; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 5: 3.
example 2
Example 2 provides a high-efficacy moisturizing and soothing repairing composition, which comprises 3% of active ingredients, 5% of chitosamine, 5% of 4D hyaluronic acid, 20% of alcohols and the balance of water in percentage by mass.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 2: 5: 1; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 15: 2.
example 3
Example 3 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% of an active ingredient, 2% of chitosamine, 3% of 4D hyaluronic acid, 12% of alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 4: 3: 0.8; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2.
example 4
Example 4 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% of an active ingredient, 2% of chitosamine, 3% of 4D hyaluronic acid, 12% of alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids; d) ceramide is used as an effective component, and the mass ratio of the ectoin, the ergothioneine, the cannabinoid and the ceramide is 4: 3: 0.8: 1.2; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2; the ceramide is triple ceramide, is a mixture of ceramide 1, ceramide 3 and ceramide 6ll, and the mass ratio of the ceramide 1 to the ceramide 3 to the ceramide 6ll is 5: 2: 1.
example 5
Example 5 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% of an active ingredient, 2% of chitosamine, 3% of 4D hyaluronic acid, 12% of alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids; d) ceramide is used as an effective component, and the mass ratio of the ectoin, the ergothioneine, the cannabinoid and the ceramide is 4: 3: 0.8: 1.2; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2; the ceramide is triple ceramide and is a mixture of ceramide 1, ceramide 3 and ceramide 6ll, and the mass ratio of the ceramide 1 to the ceramide 3 to the ceramide 6ll is 3: 3: 1.
example 6
Example 6 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% active ingredient, 2% chitosamine, 3% 4D hyaluronic acid, 12% alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids; d) ceramide is used as an effective component, and the mass ratio of the ectoin, the ergothioneine, the cannabinoid and the ceramide is 4: 3: 0.8: 1.2; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2; the ceramide is triple ceramide, is a mixture of ceramide 1, ceramide 3 and ceramide 6ll, and the mass ratio of the ceramide 1 to the ceramide 3 to the ceramide 6ll is 6: 3: 1.
example 7
Example 7 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% active ingredient, 2% chitosamine, 3% 4D hyaluronic acid, 12% alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 4: 9: 0.8; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2.
example 8
Example 8 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% active ingredient, 2% chitosamine, 3% 4D hyaluronic acid, 2% alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 4: 3: 0.8; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2.
example 9
Example 9 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% active ingredient, 2% chitosamine, 3% 4D hyaluronic acid, 12% alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 4: 3: 0.8; the alcohol is panthenol.
Example 10
Example 10 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% active ingredient, 2% chitosamine, 3% 4D hyaluronic acid, 12% alcohol, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 1: 3: 0.8; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2.
example 11
Example 11 provides a high efficacy moisturizing and soothing treatment composition comprising, by mass, 2% active ingredient, 0% chitosamine, 3% 4D hyaluronic acid, 12% alcohols, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 4: 3: 0.8; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2.
example 12
Example 12 provides a high efficacy moisturizing and soothing repairing composition comprising, by mass, 2% active ingredient, 2% chitosamine, 3% 4D hyaluronic acid, 12% alcohol, and the balance water.
The effective components comprise: a) ectoin; b) ergothioneine; c) cannabinoids are used as effective components, and the mass ratio of the ectoine, the ergothioneine and the cannabinoids is 4: 3: 2; the alcohol is a mixture of 1, 3-butanediol and 1, 2-pentanediol, and the mass ratio of the 1, 3-butanediol to the 1, 2-pentanediol is 9: 2.
performance testing
1. Cold resistance stability: the high-performance moisturizing and soothing repairing compositions of examples 1-12 were subjected to a cold resistance test, and after being left at-30 ℃ for 24 hours, the compositions were returned to room temperature (25 ℃), and whether the compositions precipitated or not was observed, and the test results are shown in table 1.
2. Centrifugal stability: the high-efficacy moisturizing and soothing composition of examples 1-12 was centrifuged at 3000r/min at room temperature (25 ℃) for 15min to observe whether the composition precipitated out, and the test results are shown in Table 1.
3. High temperature stability: the high-efficiency moisturizing and allergy-relieving repairing compositions of examples 1-12 were subjected to a high temperature test, and after being left at 40 ℃ for 24 hours, the compositions were left at-10 ℃ for 1 hour to observe whether the compositions were turbid or not.
4. Skin reparative property:
the test method comprises the following steps: the subjects continued to use the product of example 4 for 14 days and the facial images were collected using a VISIA-CR instrument incorporating the most advanced digital camera technology with multiple light sources (standard, UV, cross-polarized, parallel polarized) to improve visualization of the skin analysis.
And (3) testing results: see figures 1 and 2; FIG. 1 is a diagram of capturing images using the front face, and FIG. 2 is a diagram of capturing images using the rear face in succession 14; the darker the color in the figure, the more severely damaged the epidermis of the skin; therefore, the product has a very obvious repairing effect on the skin after being used.
TABLE 1
Claims (10)
1. An efficient moisturizing and allergy-relieving repairing composition is characterized by comprising a) ectoine in percentage by mass; b) ergothioneine or a pharmaceutically acceptable salt or ester thereof; c) cannabinoid is used as effective component, and the content of the effective component in the composition is 0.5-5%.
2. The high potency moisturizing and soothing repair composition of claim 1 wherein the mass ratio of ectoin, ergothioneine, and cannabinoid is (2-5) to (0.5-1).
3. The high potency moisturizing and soothing repair composition of claim 1 or 2 wherein the active ingredient further comprises d) ceramide, and the ceramide is present in the composition at a level of 0.1% to 1%.
4. The high potency moisturizing and soothing repair composition of claim 3 wherein the ceramide is selected from the group consisting of compounds of formula (1):
wherein: (1)
-R1represents a linear or branched, saturated or unsaturated C9-C30 hydrocarbon radical, wherein the radical may be substituted by one or more hydroxyl groups, wherein these hydroxyl groups are optionally esterified with saturated or unsaturated C16-C30 fatty acids; or a radical R "- (NR-CO) -R ', in which R represents a hydrogen atom or a mono-or polyhydroxylated, preferably monohydroxylated, C1-C10 hydrocarbon radical and R ' and R" are hydrocarbon radicals whose sum of the numbers of carbon atoms is from 9 to 30 and R ' is a divalent radical;
-R2represents a hydrogen atom, or a (glycosyl) n, (galactosyl) m or sulfogalactosyl group, wherein n is an integer from 1 to 4 and m is an integer from 1 to 8;
-R3represents a hydrogen atom, or a saturated or unsaturated C16-C27 hydrocarbon radical, wherein said radical may be substituted by one or more C1-C14 alkyl radicals, R3 may also represent a C15-C26 α -hydroxyalkyl radical, the hydroxyl radical of which may optionally be esterified with a C16-C30 α -hydroxy acid;
-R4represents a hydrogen atom, saturatedOr an unsaturated C16-C27 hydrocarbon group or a group-CH 2-CHOH-CH2-O-R6, wherein R6 represents a C10-C26 hydrocarbon group;
-R5represents a hydrogen atom, or a mono-or polyhydroxylated C1-C4 hydrocarbon group.
5. The high potency moisturizing and soothing repair composition of claim 4 wherein the ceramide is a natural ceramide selected from one or more of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6ll, ceramide 7, ceramide 8, and ceramide 9.
6. The high potency moisturizing and soothing sensitivity repairing composition according to claim 1, further comprising 0.5-5% of acetylcysteine, 5-20% of alcohol, and the balance water, by mass percent.
7. The high potency moisturizing and soothing repair composition of claim 1 further comprising 1-5% by weight of 4D hyaluronic acid.
8. The high potency moisturizing and soothing repair composition of claim 7 wherein the 4D hyaluronic acid comprises hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, sodium hyaluronate cross-linked polymer.
9. Use of a highly efficacious moisturizing and soothing composition according to any one of claims 1 to 7 in a cosmetic, preferably in the form of a solution, emulsion, viscous mixture.
10. Use of the high potency moisturizing and soothing composition of any one of claims 1-6 in a medicament, preferably a medicament for external application to the skin.
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| CN202010202864.7A CN111265420A (en) | 2020-03-20 | 2020-03-20 | Efficient moisturizing and allergy-relieving repairing composition and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107592A (en) * | 2020-09-25 | 2020-12-22 | 华熙生物科技股份有限公司 | Dental ulcer adhesive film with repairing effect and preparation method thereof |
| CN112353800A (en) * | 2020-11-10 | 2021-02-12 | 华熙生物科技股份有限公司 | Composition of hyaluronic acid or salt thereof and/or trehalose and use thereof in stabilizing ergothioneine |
| CN113616561A (en) * | 2021-09-27 | 2021-11-09 | 上海新高姿化妆品有限公司 | Composition with moisturizing and repairing effects and cosmetic |
| CN113679628A (en) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | Skin care composition for comprehensively improving skin problems and application thereof |
| CN114259453A (en) * | 2022-01-20 | 2022-04-01 | 中科东方细胞科技有限公司 | Sensitive muscle relieving and repairing spray and preparation method and application thereof |
| CN115227633A (en) * | 2022-08-17 | 2022-10-25 | 卡莱丽化妆品有限公司 | Allergy-relieving composition for sensitive skin and application thereof |
-
2020
- 2020-03-20 CN CN202010202864.7A patent/CN111265420A/en not_active Withdrawn
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112107592A (en) * | 2020-09-25 | 2020-12-22 | 华熙生物科技股份有限公司 | Dental ulcer adhesive film with repairing effect and preparation method thereof |
| CN112353800A (en) * | 2020-11-10 | 2021-02-12 | 华熙生物科技股份有限公司 | Composition of hyaluronic acid or salt thereof and/or trehalose and use thereof in stabilizing ergothioneine |
| CN113679628A (en) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | Skin care composition for comprehensively improving skin problems and application thereof |
| CN113616561A (en) * | 2021-09-27 | 2021-11-09 | 上海新高姿化妆品有限公司 | Composition with moisturizing and repairing effects and cosmetic |
| CN113616561B (en) * | 2021-09-27 | 2023-02-10 | 上海新高姿化妆品有限公司 | Composition with moisturizing and repairing effects and cosmetic |
| CN114259453A (en) * | 2022-01-20 | 2022-04-01 | 中科东方细胞科技有限公司 | Sensitive muscle relieving and repairing spray and preparation method and application thereof |
| CN115227633A (en) * | 2022-08-17 | 2022-10-25 | 卡莱丽化妆品有限公司 | Allergy-relieving composition for sensitive skin and application thereof |
| CN115227633B (en) * | 2022-08-17 | 2023-09-29 | 卡莱丽化妆品有限公司 | Sensitive skin-oriented allergy-relieving composition and application thereof |
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