CN111264633A - Children formula milk powder beneficial to intestinal health and preparation method thereof - Google Patents

Children formula milk powder beneficial to intestinal health and preparation method thereof Download PDF

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Publication number
CN111264633A
CN111264633A CN202010122658.5A CN202010122658A CN111264633A CN 111264633 A CN111264633 A CN 111264633A CN 202010122658 A CN202010122658 A CN 202010122658A CN 111264633 A CN111264633 A CN 111264633A
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powder
fruit
children
freeze
compound
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罗秋娟
战祥强
丁一鸣
闫真
吴则业
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Qingdao Suokang Food Co Ltd
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Qingdao Suokang Food Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/06—Mixtures of whey with milk products or milk components
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/02—Whey; Whey preparations containing, or treated with, microorganisms or enzymes
    • A23C21/026—Whey; Whey preparations containing, or treated with, microorganisms or enzymes containing, or treated only with, lactic acid producing bacteria, bifidobacteria or propionic acid bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/04—Whey; Whey preparations containing non-milk components as source of fats or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/08—Whey; Whey preparations containing other organic additives, e.g. vegetable or animal products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C21/00—Whey; Whey preparations
    • A23C21/10—Whey; Whey preparations containing inorganic additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/113—Acidophilus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/173—Reuteri
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/175—Rhamnosus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/515—Animalis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/531—Lactis

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a children formula milk powder beneficial to intestinal health, and belongs to the technical field of dairy products. The formula comprises skimmed milk powder, desalted whey powder, vegetable oil, 1, 3-dioleoyl-2-palmitic acid triglyceride, high fructose corn syrup, lactose, compound vitamins, compound mineral substances, calcium carbonate, choline chloride, taurine, fructo-oligosaccharide, docosahexaenoic acid powder, compound fruit powder solid beverage, compound fruit and vegetable powder solid beverage, N-acetylneuraminic acid, animal bifidobacterium Bb-12 freeze-dried powder, lactobacillus rhamnosus HN001 freeze-dried powder, lactobacillus reuteri freeze-dried powder, lactobacillus acidophilus freeze-dried powder and bifidobacterium lactis HN019 freeze-dried powder. The children formula milk powder disclosed by the invention is beneficial to intestinal health, good in absorption and capable of actively promoting growth and development of children. The invention also discloses the preparation of the milk powder base powder and the preparation of a finished product of the children formula milk powder, and the process flow is simple and easy to operate, and is suitable for large-scale production.

Description

Children formula milk powder beneficial to intestinal health and preparation method thereof
Technical Field
The invention relates to the field of children formula milk powder, in particular to children formula milk powder beneficial to intestinal health and growth of children and a preparation method thereof.
Background
The children formula milk powder is a very important nutritional supplement food in the dietary structure of children, and can supplement a large amount of high-quality protein, vitamins and minerals for children.
The invention is suitable for the minor (1-10 years old children) with the age of 1 year old and less than 10 years old, and is divided into two stages of preschool children with the age of 1-5 years old and school children with the age of 6-10 years old. The age of 1-5 years is the key period of the growth of children, the digestive system is not fully developed and mature, the immune function is poor, and 400 ml of proper formula milk powder needs to be supplemented every day to obtain enough nutrition. The children aged 6 enter the education stage of school, the growth and development are rapid, the requirement for energy and nutrients is relatively higher than that of adults, 500ml of milk product is still required every day, and sufficient nutrition can promote the normal development of intelligence and physique of the children and improve the immunity. Most of the milk powder sold in the current market is infant formula milk powder and middle-aged and elderly-aged milk powder, the types of the infant formula milk powder are few, although some nutrients are strengthened, and the infant formula milk powder has a certain promotion effect on nutrition improvement of children, the formula milk powder takes auxiliary nutrition supplement of children as a positioning, and the comprehensive and related promotion effects of probiotic addition are not considered, so that the balance requirement on intestinal health is far not met by common child milk powder. The development of the children formula milk powder which is beneficial to the intestinal health of children, helps the children to grow, has balanced nutrition, is easy to absorb, improves the immunity of the organism and promotes the development of vision and intelligence is urgently needed.
Disclosure of Invention
The invention relates to a nutritional supplement food which is specially designed and produced aiming at the growth and development characteristics of children and teenagers, and is added with a plurality of groups of nutritional components, aiming at providing a children formula milk powder which has the advantages of protecting intestinal tract balance, balancing nutrition, being easy to absorb, improving the immunity of the organism and promoting the development of vision and intelligence. The specific technical scheme is as follows:
a children formula milk powder comprises the following components in kg by weight per 1000kg of finished products: 420kg of skimmed milk powder, 280kg of desalted whey powder, 90-125kg of vegetable oil, 65kg of 1, 3-dioleate-2-palmitic acid triglyceride, 45-65kg of lactose, 40-60kg of high fructose syrup, 2kg of compound vitamin, 1kg of compound mineral substance, 7kg of calcium carbonate, 0.58kg of choline chloride, 0.4kg of taurine, 6.58kg of fructo-oligosaccharide, 2.4kg of docosahexaenoic acid powder, 3kg of compound fruit powder solid beverage, 2kg of compound fruit and vegetable powder solid beverage, 0.2kg of N-acetylneuraminic acid, 0.3kg of animal bifidobacterium Bb-12 freeze-dried powder, 0.1kg of lactobacillus rhamnosus HN001 freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of lactobacillus HN019 freeze-dried powder.
Preferably, in the technical scheme, per 1000kg, 0.3kg of bifidobacterium animalis Bb-12 freeze-dried powder, 0.1kg of rhamnosus HN001 freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of bifidobacterium lactis HN019 freeze-dried powder are added. 6.58kg of fructo-oligosaccharide. The content of Bifidobacterium animalis Bb-12 in the final product is 106CFU/g, the addition amount of rhamnose bacillus HN001 is 106CFU/g, the addition amount of the lactobacillus reuteri is 106CFU/g, the addition amount of lactobacillus acidophilus is 106CFU/g, the addition amount of Bifidobacterium lactis HN019 is 106CFU/g。
In the preferable technical scheme, in kg, every 1000kg of the docosahexaenoic acid powder contains 2.4kg, wherein the content of the docosahexaenoic acid oil accounts for 11%; the content of N-acetylneuraminic acid is 0.2 kg; the taurine content is 0.4 kg.
Preferably, in the technical scheme, the content of 1, 3-dioleoyl-2-palmitic acid triglyceride is 65kg in every 1000kg, wherein the effective content is 40%.
Preferably, in the technical scheme, in KG, each 1000KG of the composite fruit powder solid beverage contains 3KG of fruit powder, wherein the content of the fruit powder accounts for 45-55%, and 1KG of the composite fruit powder solid beverage is derived from 4.2KG of single-fruit juice/fruit pulp with the sugar degree of 12.1 degrees, which is equivalent to 5.7KG of fresh fruits. Wherein the fruit sources are as follows: apple, mango, peach, sweet orange, banana, tangerine, papaya, pineapple, red grape, snow pear, lemon, strawberry, plum, blueberry, cherry.
Preferably, in the technical scheme, in KG, in every 1000KG, the composite fruit powder solid beverage contains 23KG, the content of the fruit and vegetable powder is 48%, and 1KG of the composite fruit and vegetable powder solid beverage is derived from single-time fruit and vegetable juice or fruit and vegetable pulp with the sugar degree of 13.9 of 3.5KG, which is equivalent to 5.2KG of fresh fruits and vegetables. Wherein the fruit and vegetable sources are as follows: apple, banana, orange, pear, pineapple, tomato, carrot, kiwi, pumpkin, apricot, strawberry, white grape, cauliflower, guava, mango, melon, raspberry, molilow black cherry, peach, plum, spinach, green pea, cabbage, mushroom, red beet, lemon.
The vegetable oil comprises, by kg, 27-62.5kg of sunflower seed oil, 18-37.5kg of low erucic acid rapeseed oil, 9-31.25kg of coconut oil and 9-31.25kg of corn oil in each 1000kg of vegetable oil.
The compound vitamin contains, by g, per 1000kg of retinyl acetate 5.616-7.598g RE, cholecalciferol 0.074g-0.1g, dl- α -tocopherol acetate 18-24g, phytomenadione 0.638-0.862g, thiamine hydrochloride 5.95-8.05g, pyridoxine hydrochloride 4.676-6.326g, cyanocobalamine 0.004-0.006g, nicotinamide 32.3-43.7g, folic acid 1.87-2.53g, L-ascorbic acid 850-.
The compound mineral substance comprises, by g, every 1000kg contains 282g of ferrous sulfate 209-.
The formula and the dosage range of the invention are proved by pharmacological experiments, the technical effect which is not in the protection range of the invention is relatively poor, and the quantity of beneficial bacteria and the constipation degree are particularly obviously aggravated.
The technical scheme of the invention has the following beneficial effects:
(1) the invention adds the combination which is beneficial to intestinal health and improves immunity: five probiotics and fructo-oligosaccharide. The five probiotics include Bifidobacterium animalis Bb-12, Lactobacillus rhamnosus HN001, Lactobacillus reuteri, Lactobacillus acidophilus, and Bifidobacterium lactis HN 019. Has synergistic effect with fructo-oligosaccharide, and can effectively increase beneficial bacteria content in intestinal tract, regulate intestinal flora, inhibit harmful bacteria growth, protect intestinal mucosa, relieve constipation or diarrhea, and promote nutrient absorption.
(2) The invention adds the combination for promoting the development of the nervous system and the vision: n-acetylneuraminic acid + docosahexaenoic acid + taurine. The N-acetylneuraminic acid can effectively promote the development and functional repair of nerve cells, epithelial cells and immune cells, has the effects of improving immunity and promoting intelligence development, docosahexaenoic acid is an important component of cerebral cortex and retina, taurine has the effect of improving the light injury of the retina, and the composition can effectively protect and promote the development of a nervous system and vision.
(3) The invention adds fat optimization combination: vegetable oil +1, 3-dioleoyl-2-palmitoyl triglyceride. The vegetable oil contains oleum Helianthi, canola oil, oleum Cocois, and oleum Maydis, and is capable of providing n-3, n-6 unsaturated fatty acids required for growth of children and teenagers, and is free of hydrogenated oil and trans fatty acids. Meanwhile, the OPO structure fat can prevent the formation of calcium soap and reduce the risk of constipation.
(4) The invention provides comprehensive nutrition for the baby with food preference, and improves the taste combination: the combination of the composite fruit powder solid beverage and the composite fruit and vegetable powder solid beverage. The composite fruit powder solid beverage contains 45-55% of fruit powder, and 1KG of composite fruit powder solid beverage is derived from single fruit juice/fruit pulp with a sugar degree of 12.1 degrees at 4.2KG, and is equivalent to fresh fruit of 5.7 KG. The composite fruit and vegetable powder solid beverage contains 48% of fruit and vegetable powder, and 1KG of the composite fruit and vegetable powder solid beverage is derived from single fruit and vegetable juice or fruit and vegetable pulp with the sugar degree of 13.9 of 3.5KG, which is equivalent to 5.2KG of fresh fruits and vegetables. The 33 fruit and vegetable components can make up the nutritional defect of children with food preference and improve the taste of the product.
(5) The invention adds a plurality of vitamin mineral compositions: provides a plurality of vitamin minerals required by the growth of children and teenagers, effectively avoids the growth retardation caused by lack of nutrition, and the like, and balances the nutrition and helps the growth.
In conclusion, the children formula milk powder is specially developed according to the growth and development characteristics of children and teenagers and the dietary nutrition recommendation of WHO and Chinese nutritional society, is beneficial to the growth and development of children, and has good taste and easy absorption. The formula milk powder is beneficial to intestinal health of children and teenagers, is beneficial to absorption of nutrient substances, and improves immunity. Is helpful for the development of intelligence and eyesight of children and teenagers. Provides multiple nutrients, has balanced nutrition and helps for growth.
The invention also discloses a preparation method of the children milk powder, which specifically comprises the following steps:
the method comprises the following steps: the first mixing specifically comprises: uniformly mixing skim milk powder, desalted whey powder, vegetable oil, 1, 3-dioleate-2-palmitic acid triglyceride, lactose, high fructose corn syrup and water in a predetermined weight ratio to obtain a first ingredient;
step two: homogenizing, specifically: homogenizing the first ingredient obtained in the step one in a high-pressure homogenizer to obtain a second ingredient, wherein the homogenizing pressure is 15-20 Mpa;
step three: high-temperature sterilization, specifically comprising: sterilizing the second ingredient obtained in the step two in a plate heat exchanger, wherein the sterilization temperature is 119-125 ℃, and the sterilization time is 4-6S;
step four: and (3) mixing for the second time, specifically: adding the food nutrition enhancer added with the compound vitamins, the compound mineral substances, calcium carbonate, choline chloride and taurine into the premix, and mixing with the second ingredient to obtain a third ingredient;
step five: sterilizing and concentrating, specifically: and (3) sterilizing and concentrating the third ingredient in a three-effect multi-flow falling film evaporator, wherein the sterilization temperature is 100-106 ℃, the sterilization time is 24s, and the one-effect evaporation temperature is as follows: 70-80 ℃, double-effect evaporation temperature: 65-70 ℃, triple effect evaporation temperature: concentrating the obtained milk to a dry matter content of 40-50% at 60-70 ℃ to obtain a fourth ingredient;
step six: spray drying, specifically: and (3) carrying out spray drying on the fourth ingredient by a spray drying tower, wherein the spray equipment is an upper-exhaust vertical pressure spray drying tower, and the process conditions are as follows: the air inlet temperature of spray drying is 185-195 ℃, the air outlet temperature is 80-89 ℃, the negative pressure in the tower is 0-10mm water column, and the pressure of the high-pressure pump is 10-20 Mpa; and performing secondary drying on the powder by a fluidized bed to obtain powder, wherein the powder discharging temperature is less than or equal to 25 ℃, and the water content is less than or equal to 5.0 percent to obtain base powder;
step seven: premixing, specifically comprising: premixing fructo-oligosaccharide, docosahexaenoic acid powder, composite fruit powder solid beverage, composite fruit and vegetable powder solid beverage, N-acetylneuraminic acid, bifidobacterium animalis Bb-12 lyophilized powder, lactobacillus rhamnosus HN001 lyophilized powder, lactobacillus reuteri lyophilized powder, lactobacillus acidophilus lyophilized powder and bifidobacterium lactis HN019 lyophilized powder according to the addition amount;
step eight: mixing, namely mixing the base powder and the premix obtained in the step seven according to a formula ratio to obtain finished powder;
step nine: and packaging, detecting and warehousing.
Detailed Description
The invention discloses a children formula milk powder and a preparation method thereof, and a person skilled in the art can appropriately change process parameters by referring to the contents in the text. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
Example 1: a formula milk powder for children beneficial to intestinal health comprises the following components by weight:
475kg of skimmed milk powder, 225kg of desalted whey powder, 65kg of 1, 3-dioleate-2-palmitic acid triglyceride, 95kg of vegetable oil, 50kg of high fructose corn syrup, 62.5kg of lactose, 2kg of compound vitamin, 1kg of compound mineral, 7kg of calcium carbonate, 0.58kg of choline chloride, 0.4kg of taurine, 6.58kg of fructo-oligosaccharide, 2.4kg of docosahexaenoic acid powder, 3kg of compound fruit powder solid beverage, 2kg of compound fruit and vegetable powder solid beverage, 0.2kg of N-acetylneuraminic acid, 0.3kg of animal bifidobacterium Bb-12 freeze-dried powder, 0.1kg of lactobacillus rhamnosus HN001 freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of bifidobacterium lactis HN019 freeze-dried powder.
The vegetable oil is a mixture of 38kg of sunflower seed oil, 23.75kg of low erucic acid rapeseed oil, 16.625kg of coconut oil and 16.625kg of corn oil.
The compound vitamin comprises 6.607g RE acetate, 0.087g cholecalciferol, 21g dl- α -tocopheryl acetate, 0.75g plant menadione, 7.0g thiamine hydrochloride, 5.501g pyridoxine hydrochloride, 0.005g cyanocobalamine, 38g nicotinamide, 2.2g folic acid and 1000g L-ascorbic acid.
The compound mineral substance is 245.5g of ferrous sulfate, 174.5g of zinc sulfate, 0.014g of copper sulfate and 0.00025g of sodium selenite.
A children formula milk powder beneficial to intestinal health is prepared by the following steps:
the method comprises the following steps: the first mixing specifically comprises: uniformly mixing skim milk powder, desalted whey powder, vegetable oil, 1, 3-dioleate-2-palmitic acid triglyceride, lactose, high fructose corn syrup and water in a predetermined weight ratio to obtain a first ingredient;
step two: homogenizing, specifically: homogenizing the first ingredient obtained in the step one in a high-pressure homogenizer to obtain a second ingredient, wherein the homogenizing pressure is 15-20 Mpa;
step three: high-temperature sterilization, specifically comprising: sterilizing the second ingredient obtained in the step two in a plate heat exchanger, wherein the sterilization temperature is 119-125 ℃, and the sterilization time is 4-6S;
step four: and (3) mixing for the second time, specifically: adding the food nutrition enhancer added with the compound vitamins, the compound mineral substances, calcium carbonate, choline chloride and taurine into the premix, and mixing with the second ingredient to obtain a third ingredient;
step five: sterilizing and concentrating, specifically: and (3) sterilizing and concentrating the third ingredient in a three-effect multi-flow falling film evaporator, wherein the sterilization temperature is 100-106 ℃, the sterilization time is 24s, and the one-effect evaporation temperature is as follows: 70-80 ℃, double-effect evaporation temperature: 65-70 ℃, triple effect evaporation temperature: concentrating the obtained milk to a dry matter content of 40-50% at 60-70 ℃ to obtain a fourth ingredient;
step six: spray drying, specifically: and (3) carrying out spray drying on the fourth ingredient by a spray drying tower, wherein the spray equipment is an upper-exhaust vertical pressure spray drying tower, and the process conditions are as follows: the air inlet temperature of spray drying is 185-195 ℃, the air outlet temperature is 80-89 ℃, the negative pressure in the tower is 0-10mm water column, and the pressure of the high-pressure pump is 10-20 Mpa; and performing secondary drying on the powder by a fluidized bed to obtain powder, wherein the powder discharging temperature is less than or equal to 25 ℃, and the water content is less than or equal to 5.0 percent to obtain base powder;
step seven: premixing, specifically, mixing fructo-oligosaccharide, docosahexaenoic acid powder, composite fruit powder solid beverage, composite fruit and vegetable powder solid beverage, N-acetylneuraminic acid, bifidobacterium animalis Bb-12 lyophilized powder, lactobacillus rhamnosus HN001 lyophilized powder, lactobacillus reuteri lyophilized powder, lactobacillus acidophilus lyophilized powder and bifidobacterium lactis HN019 lyophilized powder according to the addition amount;
step eight: mixing, namely mixing the base powder and the premix obtained in the step seven according to a formula ratio to obtain finished powder;
step nine: and packaging, detecting and warehousing.
Example 2: a formula milk powder for children beneficial to intestinal health comprises the following components by weight:
420kg of skimmed milk powder, 280kg of desalted whey powder, 65kg of 1, 3-dioleic acid-2-palmitic acid triglyceride, 125kg of vegetable oil, 40kg of high fructose corn syrup, 45kg of lactose, 2kg of compound vitamin, 1kg of compound mineral, 7kg of calcium carbonate, 0.58kg of choline chloride, 0.4kg of taurine, 6.58kg of fructo-oligosaccharide, 2.4kg of docosahexaenoic acid powder, 3kg of compound fruit powder solid beverage, 2kg of compound fruit and vegetable powder solid beverage, 0.2kg of N-acetylneuraminic acid, 0.1kg of animal bifidobacterium Bb-120.3 freeze-dried powder, 0.1kg of lactobacillus rhamnosus HN001 freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of lactobacillus HN019 freeze-dried powder.
The vegetable oil is a mixture of 50kg of sunflower seed oil, 31.25kg of low erucic acid rapeseed oil, 21.875kg of coconut oil and 21.875kg of corn oil.
The compound vitamin contains 5.616g RE acetate, 0.074gg cholecalciferol, 184g dl- α -tocopheryl acetate, 0.6382g plant menadione, 5.955g thiamine hydrochloride, 4.676g pyridoxine hydrochloride, 0.004g cyanocobalamine, 32.3g nicotinamide, 1.87g folic acid and 850g L-ascorbic acid.
The compound mineral comprises 209g of ferrous sulfate, 149g of zinc sulfate, 0.012g of copper sulfate and 0.0002g of sodium selenite.
The specific preparation method is the same as that of example 1.
Example 3: a formula milk powder for children beneficial to intestinal health comprises the following components by weight:
490kg of skimmed milk powder, 210kg of desalted whey powder, 65kg of 1, 3-dioleate-2-palmitic acid triglyceride, 100kg of vegetable oil, 50kg of high fructose corn syrup, 60kg of lactose, 2kg of compound vitamin, 1kg of compound mineral, 7kg of calcium carbonate, 0.58kg of choline chloride, 0.4kg of taurine, 6.58kg of fructo-oligosaccharide, 2.4kg of docosahexaenoic acid powder, 3kg of compound fruit powder solid beverage, 2kg of compound fruit and vegetable powder solid beverage, 0.2kg of N-acetylneuraminic acid, 0.3kg of animal bifidobacterium Bb-12 freeze-dried powder, 0.1kg of lactobacillus rhamnosus HN001 freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of lactobacillus HN019 freeze-dried powder.
The vegetable oil is a mixture of 40kg of sunflower seed oil, 25kg of low erucic acid rapeseed oil, 17.5kg of coconut oil and 17.5kg of corn oil.
The compound vitamin contains 7.598g RE acetate, 0.1g cholecalciferol, 24g dl- α -tocopheryl acetate, 0.862g plant menadione, 8.05g thiamine hydrochloride, 6.326g pyridoxine hydrochloride, 0.006g cyanocobalamine, 43.7g nicotinamide, 2.53g folic acid and 1150g L-ascorbic acid.
The compound mineral comprises 282g of ferrous sulfate, 200g of zinc sulfate, 0.016g of copper sulfate and 0.0003g of sodium selenite.
The specific preparation method is the same as that of example 1.
Comparative example 1: a formula milk powder for children beneficial to intestinal health comprises the following components by weight: 475kg of skimmed milk powder, 225kg of desalted whey powder, 65kg of 1, 3-dioleic acid-2-palmitic acid triglyceride, 95kg of vegetable oil, 50kg of high fructose corn syrup, 62.5kg of lactose, 2kg of compound vitamin, 1kg of compound mineral, 7kg of calcium carbonate, 0.58kg of choline chloride, 0.4kg of taurine, 2.4kg of docosahexaenoic acid powder, 3kg of compound fruit powder solid beverage, 2kg of compound fruit and vegetable powder solid beverage, 0.2kg of N-acetylneuraminic acid, 0.3kg of bifidobacterium animalis Bb-12 freeze-dried powder, 0.1kg of lactobacillus rhamnosus HN001 freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of bifidobacterium lactis HN019 freeze-dried powder.
The vegetable oil is a mixture of 38kg of sunflower seed oil, 23.75kg of low erucic acid rapeseed oil, 16.625kg of coconut oil and 16.625kg of corn oil.
The compound vitamin comprises 6.607g RE acetate, 0.087g cholecalciferol, 21g dl- α -tocopheryl acetate, 0.75g plant menadione, 7.0g thiamine hydrochloride, 5.501g pyridoxine hydrochloride, 0.005g cyanocobalamine, 38g nicotinamide, 2.2g folic acid and 1000g L-ascorbic acid.
The compound mineral substance is 245.5g of ferrous sulfate, 174.5g of zinc sulfate, 0.014g of copper sulfate and 0.00025g of sodium selenite.
The specific preparation method is the same as that of example 1.
Comparative example 2: a formula milk powder for children beneficial to intestinal health comprises the following components by weight: 475kg of skimmed milk powder, 225kg of desalted whey powder, 65kg of 1, 3-dioleate-2-palmitic acid triglyceride, 95kg of vegetable oil, 50kg of high fructose corn syrup, 62.5kg of lactose, 2kg of compound vitamin, 1kg of compound mineral, 7kg of calcium carbonate, 0.58kg of choline chloride, 0.4kg of taurine, 6.58kg of fructo-oligosaccharide, 2.4kg of docosahexaenoic acid powder, 0.2kg of N-acetylneuraminic acid, 0.3kg of bifidobacterium animalis Bb-12 freeze-dried powder, 0.1kg of lactobacillus rhamnosus 001 HN freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of bifidobacterium lactis HN freeze-dried powder.
The vegetable oil is a mixture of 38kg of sunflower seed oil, 23.75kg of low erucic acid rapeseed oil, 16.625kg of coconut oil and 16.625kg of corn oil.
The compound vitamin comprises 6.607g RE acetate, 0.087g cholecalciferol, 21g dl- α -tocopheryl acetate, 0.75g plant menadione, 7.0g thiamine hydrochloride, 5.501g pyridoxine hydrochloride, 0.005g cyanocobalamine, 38g nicotinamide, 2.2g folic acid and 1000g L-ascorbic acid.
The compound mineral substance is 245.5g of ferrous sulfate, 174.5g of zinc sulfate, 0.014g of copper sulfate and 0.00025g of sodium selenite.
Verification example 1: experiment of children formula milk powder on intestinal bifidobacteria and lactobacillus
1 materials and methods
The entrusting unit: shandong New era pharmaceutical Co Ltd
Animals: LACA homozygous mice, female, 6-8 weeks old.
The formula milk powder for children to be detected comprises the following components: children formula of example 1 and comparative example 1
And detecting a target product bifidobacterium.
The experimental method comprises the following steps: the mice were randomly divided into 5 groups of 10 mice each, and divided into a blank control group to which physiological saline was administered and a test group to which the low dose group of example 1, the high dose group of example 1, and the dose group of comparative example 1 were administered for 7 consecutive days, orally. And (4) taking intestinal contents for flora analysis at the 8 th day, wherein a viable count method is adopted in-vitro and in-vivo flora analysis experiments.
Statistical treatment: all experimental data are expressed as mean ± standard deviation and tested for interclass significance t using the sps 17.0 software.
1.2 results
1.2.1 Effect on intestinal flora growth in vivo
TABLE 1 Effect of in vivo experiments on growth of intestinal flora in Normal mice
Figure BDA0002393455010000071
Figure BDA0002393455010000081
Note:※indicating that the difference was very significant (p) compared with the group of comparative example 1<0.05)；
※※Indicating that the difference was very significant (p) compared with the group of comparative example 1<0.01)；
▲Indicating that the difference was very significant (p) compared with the group of comparative example 1<0.05)；
▲▲Shows the comparison with the group of comparative example 1The difference is extremely remarkable (p)<0.05)。
As can be seen from Table 1, the results show that the children formula of example 1 has a significant effect of promoting intestinal bifidobacteria in normal mice. Compared with comparative example 1, the example 1 of the application has significant difference (p <0.01) under the condition of equivalent dosage.
Verification example 2: action research of children formula milk powder on constipation model mice
2.1 materials and methods
The entrusting unit: shandong New era pharmaceutical Co Ltd, Lunan pharmaceutical group
Animals: LACA homozygous mice, female, 6-8 weeks old.
2.2 design of the experiment
The method is carried out according to the recommended detection method of the bowel relaxing function of the health food. The experimental mice were then divided into 6 groups (blank control group, model group, examples 1-3 groups, comparative example 1 group) of 10 mice each. Examples 1-3 groups of products of the present application example 1, example 2, example 3, blank control group and model control group were administered orally with equal amounts of ordinary children's formula, respectively. Test samples were administered once daily for 12 consecutive days. Each animal was individually housed after the last administration of the test sample. After each group of mice was fasted for 24 hours without water deprivation, the model control group and the test group were gavaged with compound diphenoxylate (10mg/kg), and the blank control group was given with distilled water in equal amounts. After 15 minutes of administration of the compound diphenoxylate, the model control group and the blank control group were administered with ink for intragastric administration, the test group was administered with each ink containing the corresponding test sample, filter paper was laid under each cage, and timing was started. The time of the first defecation, the number of defecation granules within 8 hours and the weight of each animal were observed and recorded.
2.3 test results
TABLE 2 Effect on mouse defecation time, number of particles and stool weight
Figure BDA0002393455010000082
Figure BDA0002393455010000091
Note:&&indicates that the difference is very significant compared with the model control group (p)<0.01)；※※Shows a very significant difference (p) from comparative example 1<0.01)；▲▲Indicating a very significant difference (p) compared to the blank control group<0.01)。
As can be seen from table 2, after the test article is orally administered for 12 days, the time of the first black stool of the mice in the model control group is significantly longer than that in the blank control group within 8 hours, which indicates that the molding of the embodiment of the present invention is successful. The first black stool time of the children formula milk powder in the embodiments 1-3 is obviously shorter than that of the model control group and the group of the comparative embodiment, and after the children formula milk powder in the embodiments 1-3 is orally administered to a constipation mouse model, the first black stool time of the constipation mouse can be shortened, the number of the first black stools of the constipation mouse can be increased, and the children formula milk powder has better functions of assisting in relaxing bowels and relieving constipation and is suitable for further popularization and application.
Verification example 3: human body test
To further verify the formula of the invention, 32 children aged 2-3 in the company range were given free milk powder for 10 months in 2018.10-2019, and the conditions such as height and age of the children were not significantly different, and the formula was subjected to telephone tracking statistics.
3.1 packet mode
Experimental groups: the children formula milk powder in the embodiment 1 of the invention is added with complementary food 2-3 times per day, and 16 children formula milk powder is half for men and women.
Observation group: the commercial formula milk powder is added with supplementary food 2-3 times per day, 16 cases are half of the total number of people.
3.2 diagnostic criteria
Over the last 12 months, there was a duration or accumulation of at least 12 weeks with the following 2 or more symptoms:
(1)1/4 it is time consuming to defecate; (2)1/4, time; (3) defecation is not complete when the time is more than 1/4; (4) greater than 1/4 times, the anus has a feeling of obstruction or difficulty in expulsion; (5) when defecation occurs more than 1/4 time, the support is needed to assist (support pelvic floor muscle obstruction); (6) less than 3 bowel movements per week are based on the general classification of functional constipation into three types: slow Transit Constipation (STC), Outlet Obstruction Constipation (OOC), and mixed constipation (MIX).
3.3 diagnosis of therapeutic effects and clinical results
The excrement is in the shape of block mass or hard, difficult defecation occurs in the part and the power disorder, the excrement is not smooth, the quality is firm, and the symptoms of pain, abdominal distension and inappetence are caused.
Constipation can be achieved by at least 2 characters; the constipation type can be mild if 1 character exists; none of the above characters is constipation-free.
The specific results are shown in Table 3.
TABLE 3 Constipation status in the treatment and observation groups
Figure BDA0002393455010000092
Figure BDA0002393455010000101
As can be seen from Table 3, only 1 example of mild constipation occurred occasionally in the experimental group, 3 examples of constipation occurred occasionally in the observation group, and 5 examples of mild constipation type, which were preliminarily considered to be caused by the ingredients of the commercial formula.
Verification example 4: human body test
According to the voluntary principle, 40 employees of the company are selected, 10 persons in each group are selected, and 40 persons in total are selected, and the human mouth sensitivity test is carried out by selecting examples 1-3 and comparative example 2, which are as follows:
degree of mouthfeel: very satisfactory 10 points, satisfactory 7 points, generally 3 points, and 1 point difference.
Degree of digestion: satiety at 3-5 hours overnight: very satisfactory 10 points, satisfactory 7 points, generally 3 points, and 1 point difference.
Odor: the faint scent degree is 10 points satisfactory, 7 points satisfactory, 3 points generally and 1 point worse.
As a result: the final scores were pooled and statistically analyzed using a sps 17.0.
TABLE 4 human correlation test of examples 6-8 and comparative examples 4-6
Figure BDA0002393455010000102
Item Example 1 Example 2 Example 3 Comparative example 2
Degree of mouthfeel 99.8±13.3&& 94.6±11.7&& 95.6±15.6&& 65.9±17.7
Degree of digestion 98.9±15.1 93.2±15.8 95.5±8.9 96.3±13.4
Smell(s) 99.3±14.9&& 92.8±14.9&& 99.3±17.7&& 76.7±10.9
Note:&shows a very significant difference (p) compared to comparative example 2<0.05)
As can be seen from Table 4, the examples 1 to 3 used in the present invention are significantly superior to the group of comparative example 2 in the degree of mouthfeel, the degree of digestion, and the odor, and particularly, the indexes of example 1 are superior to those of the other examples. In the formula of the comparative example 2, the compound fruit powder solid beverage and the compound fruit and vegetable powder solid beverage are not contained, and the mouthfeel is poor.

Claims (10)

1. The children formula milk powder is characterized by mainly comprising the following components: skim milk powder, desalted whey powder, vegetable oil, 1, 3-dioleate-2-palmitic acid triglyceride, lactose, high fructose corn syrup, compound vitamins, compound mineral substances, calcium carbonate, choline chloride, taurine, fructo-oligosaccharide, docosahexaenoic acid powder, compound fruit powder solid beverage, compound fruit and vegetable powder solid beverage, N-acetylneuraminic acid, bifidobacterium animalis Bb-12 freeze-dried powder, lactobacillus rhamnosus HN001 freeze-dried powder, lactobacillus reuteri freeze-dried powder, lactobacillus acidophilus freeze-dried powder and bifidobacterium lactis HN019 freeze-dried powder.
2. The children's formula according to claim 1, wherein: the formula comprises the following components in terms of per 1000kg of finished milk powder: 420kg of skimmed milk powder, 280kg of desalted whey powder, 90-125kg of vegetable oil, 65kg of 1, 3-dioleate-2-palmitic acid triglyceride, 45-65kg of lactose, 40-60kg of high fructose syrup, 2kg of compound vitamin, 1kg of compound mineral substance, 7kg of calcium carbonate, 0.58kg of choline chloride, 0.4kg of taurine, 6.58kg of fructo-oligosaccharide, 2.4kg of docosahexaenoic acid powder, 3kg of compound fruit powder solid beverage, 2kg of compound fruit and vegetable powder solid beverage, 0.2kg of N-acetylneuraminic acid, 0.3kg of animal bifidobacterium Bb-12 freeze-dried powder, 0.1kg of lactobacillus rhamnosus HN001 freeze-dried powder, 0.1kg of lactobacillus reuteri freeze-dried powder, 0.1kg of lactobacillus acidophilus freeze-dried powder and 0.1kg of lactobacillus HN019 freeze-dried powder.
3. The children formula milk powder as claimed in claim 2, wherein the vegetable oil is a mixture of 27-62.5kg of sunflower seed oil, 18-37.5kg of canola oil, 9-31.25kg of coconut oil and 9-31.25kg of corn oil, the compound vitamins are retinyl acetate 5.616-7.598g RE, cholecalciferol 0.074g-0.1g, dl- α -tocopherol acetate 18-24g, phytomenadione 0.638-0.862g, thiamine hydrochloride 5.95-8.05g, pyridoxine hydrochloride 4.676-6.326g, cyanocobalamine 0.004-0.006g, nicotinamide 32.3-43.7g, folic acid 1.87-2.53g and L-ascorbic acid 850g, the compound minerals are ferrous sulfate 282-209-1150 g, zinc sulfate 200g, copper sulfate 0.012-0.016g, sodium selenite 0.0192.0192-0003 g and bifidobacterium 3-00010 g, calculated by HN 10 g6CFU/g, Bifidobacterium animalis Bb-12106CFU/g, Lactobacillus rhamnosus HN019106CFU/g, Lactobacillus reuteri 106CFU/g, Lactobacillus acidophilus 106CFU/g; the content of fructo-oligosaccharide is 6.58kg in kg; in kg, every 1000kg of the docosahexaenoic acid powder contains 2.4kg, wherein the content of docosahexaenoic acid grease accounts for 11%; the content of N-acetylneuraminic acid is 0.2 kg; the taurine content is 0.4 kg; the children's formula according to claim 1, characterized in that: in kg, per 1000kg, the content of 1, 3-dioleoyl-2-palmitic acid triglyceride is 65kg, wherein the effective content is 40%.
4. The children's formula according to claim 2, wherein: in KG, in every 1000KG of the composite fruit powder solid beverage, the content of the fruit powder is 45-55%, and 1KG of the composite fruit powder solid beverage is derived from single fruit juice/fruit pulp with the sugar degree of 12.1 degrees of 4.2KG and is equivalent to fresh fruit of 5.7 KG; wherein the fruit sources are as follows: apple, mango, peach, sweet orange, banana, tangerine, papaya, pineapple, red grape, snow pear, lemon, strawberry, plum, blueberry, cherry.
5. The children's formula according to claim 2, wherein: in KG, in every 1000KG of the composite fruit powder solid beverage, 23KG of the composite fruit powder solid beverage contains 48 percent of fruit and vegetable powder, 1KG of the composite fruit and vegetable powder solid beverage is derived from single fruit and vegetable juice or fruit and vegetable pulp with the sugar degree of 3.5KG of 13.9 degrees, which is equivalent to 5.2KG of fresh fruits and vegetables, wherein the fruit and vegetable sources are as follows: apple, banana, orange, pear, pineapple, tomato, carrot, kiwi, pumpkin, apricot, strawberry, white grape, cauliflower, guava, mango, melon, raspberry, molilow black cherry, peach, plum, spinach, green pea, cabbage, mushroom, red beet, lemon.
6. A method of preparing a children's formula according to any of claims 1 to 5, comprising the steps of:
a) adding water into skimmed milk powder, desalted whey powder, vegetable oil, 1, 3-dioleate-2-palmitic acid triglyceride, lactose, high fructose corn syrup, compound vitamins, compound minerals, calcium carbonate, choline chloride and taurine, mixing together, and homogenizing to obtain a mixed solution.
b) And sterilizing, concentrating and spray drying the mixed solution to obtain powder.
c) Adding docosahexaenoic acid powder, fructo-oligosaccharide, composite fruit powder solid beverage, composite fruit and vegetable powder solid beverage, N-acetylneuraminic acid, bifidobacterium animalis Bb-12 lyophilized powder, lactobacillus rhamnosus HN001 lyophilized powder, lactobacillus reuteri lyophilized powder, lactobacillus acidophilus lyophilized powder and bifidobacterium lactis HN019 lyophilized powder into the powder, sieving, inspecting, and packaging to obtain the product.
7. The method for preparing a children's formula milk powder according to claim 6, wherein the mixing temperature is 50-65 ℃ and the homogenizing pressure is 15-20Mpa in step a).
8. The method for preparing a milk formula for children as claimed in claim 6, wherein in step b), the sterilization temperature is 100 ℃ and the sterilization time is 24S; the air inlet temperature of spray drying is 185-195 ℃, and the air outlet temperature is 80-89 ℃.
9. Method for preparing a children's formula milk powder according to claim 6, characterized in that it comprises the following steps:
the method comprises the following steps: mixing for the first time: uniformly mixing skim milk powder, desalted whey powder, vegetable oil, 1, 3-dioleate-2-palmitic acid triglyceride, lactose, high fructose corn syrup and water in a predetermined weight ratio to obtain a first ingredient;
step two: homogenizing, specifically: homogenizing the first ingredient obtained in the step one in a high-pressure homogenizer to obtain a second ingredient, wherein the homogenizing pressure is 15-20 Mpa;
step three: high-temperature sterilization: sterilizing the second ingredients obtained in the step two in a plate heat exchanger at the temperature of 119 ℃
The temperature is 125 ℃, and the time is 4-6S;
step four: and (3) mixing for the second time: adding the food nutrition enhancer added with the compound vitamins, the compound mineral substances, calcium carbonate, choline chloride and taurine into the premix, and mixing with the second ingredient to obtain a third ingredient;
step five: sterilization and concentration: and (3) sterilizing and concentrating the third ingredient in a three-effect multi-flow falling film evaporator, wherein the sterilization temperature is 100-106 ℃, the sterilization time is 24s, and the one-effect evaporation temperature is as follows: 70-80 ℃, double-effect evaporation temperature: 65-70 ℃, triple effect evaporation temperature: concentrating the obtained milk to a dry matter content of 40-50% at 60-70 ℃ to obtain a fourth ingredient;
step six: spray drying: and (3) carrying out spray drying on the fourth ingredient by a spray drying tower, wherein the spray equipment is an upper-exhaust vertical pressure spray drying tower, and the process conditions are as follows: the air inlet temperature of spray drying is 185-195 ℃, the air outlet temperature is 80-89 ℃, the negative pressure in the tower is 0-10mm water column, and the pressure of the high-pressure pump is 10-20 Mpa; and performing secondary drying on the powder by a fluidized bed to obtain powder, wherein the powder discharging temperature is less than or equal to 25 ℃, and the water content is less than or equal to 5.0 percent to obtain base powder;
step seven: premixing: premixing fructo-oligosaccharide, docosahexaenoic acid powder, composite fruit powder solid beverage, composite fruit and vegetable powder solid beverage, N-acetylneuraminic acid, bifidobacterium animalis Bb-12 lyophilized powder, lactobacillus rhamnosus HN001 lyophilized powder, lactobacillus reuteri lyophilized powder, lactobacillus acidophilus lyophilized powder and bifidobacterium lactis HN019 lyophilized powder according to the addition amount;
step eight: mixing, namely mixing the base powder and the premix obtained in the step seven according to a formula ratio to obtain finished powder;
step nine: and packaging, detecting and warehousing.
10. Use of a children's formula according to claim 1 for improving the intestinal health of children between 1 and 10 years of age.
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